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https://www.readbyqxmd.com/read/28431266/reduced-abnormal-integration-of-adult-generated-granule-cells-does-not-attenuate-spontaneous-recurrent-seizures-in-mice
#1
Kun Zhu, Bo Yuan, Ming Hu, Gai-Feng Feng, Yong Liu, Jian-Xin Liu
Epileptic seizures lead to aberrant hippocampal neurogenesis, including increased proliferation of neural progenitors and abnormal integrations of newly generated granule cells - hilar ectopic granule cells (EGCs), mossy fiber sprouting (MFS), and hilar basal dendrites (HBDs). Previous results from ablating hippocampal neurogenesis after acute seizures have been controversial with regards to the development of spontaneous recurrent seizures (SRSs). While ablation of hippocampal newborn cells was effective, a sufficient decrease of subsequent abnormal integrations in chronically epileptic hippocampus was not well-established in these studies...
April 11, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28418222/modified-loop-myopexy-technique-for-severe-high-myopic-strabismus-fixus
#2
Leilei Zou, Shuai Liu, Rui Liu, Yao Jing, Yan Liu, Jing Lin, Hong Liu
IMPORTANCE: This study introduces a modified loop myopexy technique for severe high myopic strabismus fixus (MSF). BACKGROUND: To evaluate the surgical results of loop myopexy with or without medial rectus (MR) recession for the treatment of patients with MSF. DESIGN: A retrospective study in a Chinese teaching hospital. PARTICIPANTS: Data was collected from 25 MSF patients (33 eyes) with restriction in both abduction and sursumduction...
April 18, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28416965/a-crisis-of-protection-and-safe-passage-violence-experienced-by-migrants-refugees-travelling-along-the-western-balkan-corridor-to-northern-europe
#3
Jovana Arsenijević, Erin Schillberg, Aurelie Ponthieu, Lucio Malvisi, Waeil A Elrahman Ahmed, Stefano Argenziano, Federica Zamatto, Simon Burroughs, Natalie Severy, Christophe Hebting, Brice de Vingne, Anthony D Harries, Rony Zachariah
BACKGROUND: Pushed by ongoing conflicts and pulled by the desire for a better life, over one million migrants/refugees transited Balkan countries and arrived in Europe during 2015 and early 2016. To curb this influx, European countries instituted restrictive migration policies often characterized by building of razor-wire border fences and border closures. Among migrants/refugees who received mental health care in Serbia while travelling through Balkan countries to Northern Europe, we assessed the prevalence and patterns of violent events experienced including physical trauma...
2017: Conflict and Health
https://www.readbyqxmd.com/read/28408252/israeli-spotted-fever-in-sicily-description-of-two-cases-and-minireview
#4
REVIEW
Claudia Colomba, Marcello Trizzino, Anna Giammanco, Celestino Bonura, Danilo Di Bona, Manlio Tolomeo, Antonio Cascio
Mediterranean spotted fever (MSF) is endemic in Italy where Rickettsia conorii subsp. conorii was thought to be the only pathogenic rickettsia and Rhipicephalus sanguineus the vector and main reservoir. R. conorii subsp. israelensis, which belongs to the R. conorii complex, is the agent of Israeli spotted fever (ISF); apart from Israel, it has also been found in Italy (Sicily and Sardinia) and in different regions of Portugal. We describe here two severe cases of ISF which occurred in otherwise healthy Italian adults...
April 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28400971/the-mini-pat-as-a-multi-source-feedback-tool-for-trainees-in-child-and-adolescent-psychiatry-assessing-whether-it-is-fit-for-purpose
#5
Gill Salmon, Lesley Pugsley
This paper discusses the research supporting the use of multi-source feedback (MSF) for doctors and describes the mini-Peer Assessment Tool (mini-PAT), the MSF instrument currently used to assess trainees in child and adolescent psychiatry. The relevance of issues raised in the literature about MSF tools in general is examined in relation to trainees in child and adolescent psychiatry as well as the appropriateness of the mini-PAT for this group. Suggestions for change including modifications to existing MSF tools or the development of a specialty-specific MSF instrument are offered...
April 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28368858/epidemiological-evaluation-of-mediterranean-spotted-fever-in-children-of-the-karak-province-in-south-jordan
#6
Omar Nafi, Yasseen Tarawnah, Amjad Tarawnah
INTRODUCTION: The aim of this study was to describe the epidemiological patterns of Mediterranean spotted fever (MSF) as well as its treatment and outcomes in children in south Jordan. METHODOLOGY: A retrospective observational study was conducted from June 2013 to December 2015. Data regarding demographics, clinical presentation, laboratory findings, treatment, and outcomes were collected. RESULTS: In total, 35 male and 20 female patients (mean age: 6 years ± 3...
March 31, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28355307/mediterranean-spotted-fever-in-spain-1997-2014-epidemiological-situation-based-on-hospitalization-records
#7
Zaida Herrador, Amalia Fernandez-Martinez, Diana Gomez-Barroso, Inmaculada León, Carmen Vieira, Antonio Muro, Agustín Benito
INTRODUCTION: Mediterranean spotted fever (MSF) is a zoonotic disease caused by Rickettsia conorii. In Spain, deficiencies in the official reporting result in misreporting of this disease. This study aims to describe the clinical and temporal-spatial characteristics of MSF hospitalizations between 1997 and 2014. MATERIALS AND METHODS: We performed a retrospective descriptive study using the Hospitalization Minimum Data Set (CMBD). All CMBD's hospital discharges with ICD-9 CM code 082...
2017: PloS One
https://www.readbyqxmd.com/read/28348768/myocarditis-in-mediterranean-spotted-fever-a-case-report-and-a-review-of-the-literature
#8
Claudia Colomba, Lucia Siracusa, Marcello Trizzino, Claudia Gioè, Anna Giammanco, Antonio Cascio
INTRODUCTION: Mediterranean spotted fever (MSF) is a tick-borne acute febrile disease caused by Rickettsia conorii. Most cases follow a benign course, with a case fatality rate of 3-7 % among hospitalized patients. Complications are described mainly in adult patients and include hepatic, renal, neurological and cardiac impairment. Among cardiac complications, pericarditis, myocarditis and heart rhythm disorders are uncommon complications in MSF and only a few cases have been reported in the literature...
August 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28320759/basic-occupational-health-services-bohs-in-community-primary-care-the-msf-dhaka-model
#9
Venkiteswaran Muralidhar, Md Faizul Ahasan, Ahad Mahmud Khan, Mohammad Shariful Alam
The Médecins Sans Frontiérs (MSF) established basic occupational health services to diagnose and treat work-related diseases among tannery, metal, plastics and garment workers and families in one of the more polluted areas of the world populated by 600 000 people. In spite of project limitations, an analysis of the 6-month data showed that of the original cohort of 5000, 3200 (64%) came for at least 1 consultation. Among them, 468 (14.6%) were diagnosed with suspected work-related diseases as per defined protocols...
March 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28317860/gene-delivery-to-nile-tilapia-cells-for-transgenesis-and-the-role-of-pi3k-c2%C3%AE-in-angiogenesis
#10
Fernanda Maria Policarpo Tonelli, Samyra Maria Dos Santos Nassif Lacerda, Marcela Santos Procópio, Breno Luiz Sales Lemos, Luiz Renato de França, Rodrigo Ribeiro Resende
Microinjection is commonly performed to achieve fish transgenesis; however, due to difficulties associated with this technique, new strategies are being developed. Here we evaluate the potential of lentiviral particles to genetically modify Nile tilapia cells to achieve transgenesis using three different approaches: spermatogonial stem cell (SSC) genetic modification and transplantation (SC), in vivo transduction of gametes (GT), and fertilised egg transduction (ET). The SC protocol using larvae generates animals with sustained production of modified sperm (80% of animals with 77% maximum sperm fluorescence [MSF]), but is a time-consuming protocol (sexual maturity in Nile tilapia is achieved at 6 months of age)...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303086/anesthesia-provision-in-disasters-and-armed-conflicts
#11
REVIEW
Miguel Trelles Centurion, Rafael Van Den Bergh, Henry Gray
PURPOSE OF REVIEW: Disasters and armed conflicts are characterized by high numbers of trauma cases, and occur mainly in developing countries where the healthcare response is already impaired, resulting in an inadequate response. Aside of the trauma cases, other surgical health conditions are also still present and require urgent care. Surgical care needs are different from context to context and depend on local means and capabilities. RECENT FINDINGS: Doctors without Borders (MSF) has proven that even in precarious situations, safe administration of anesthesia is possible, and the "do no harm" principle can and must be upheld...
2017: Current Anesthesiology Reports
https://www.readbyqxmd.com/read/28282377/before-the-bombing-high-burden-of-traumatic-injuries-in-kunduz-trauma-center-kunduz-afghanistan
#12
Hamayoun Hemat, Safieh Shah, Petros Isaakidis, Mrinalini Das, Nang Thu Thu Kyaw, Sattar Zaheer, Abdul Qayeum Qasemy, Mutallib Zakir, Gbane Mahama, Catherine Van Overloop, Lynette Dominguez
BACKGROUND: Médecins Sans Frontières (MSF) has been providing healthcare in Afghanistan since 1981 including specialized health services for trauma patients in Kunduz Trauma Center (KTC) from 2011. On October 3rd, 2015, a US airstrike hit the KTC, killing 42 people including 14 MSF staff. This study aims to demonstrate the impact on healthcare provision, after hospital destruction, by assessing the extent of care provided for trauma and injuries by the MSF KTC and to report on treatment outcomes from January 2014 to June 2015, three months prior to the bombing...
2017: PloS One
https://www.readbyqxmd.com/read/28215187/experiences-of-ebola-survivors-causes-of-distress-and-sources-of-resilience
#13
Patricia M Schwerdtle, Veronique De Clerck, Virginia Plummer
Introduction An appreciation of the experience of Ebola survivors is critical for community engagement and an effective outbreak response. Few qualitative, descriptive studies have been conducted to date that concentrate on the voices of Ebola survivors. Problem This study aimed to explore the experiences of Ebola survivors following the West African epidemic of 2014. METHOD: An interpretive, qualitative design was selected using semi-structured interviews as the method of data collection...
February 20, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28212117/validation-of-the-incept-a-multisource-feedback-tool-for-capturing-different-perspectives-on-physicians-professional-performance
#14
Mirja W van der Meulen, Benjamin C M Boerebach, Alina Smirnova, Sylvia Heeneman, Mirjam G A Oude Egbrink, Cees P M van der Vleuten, Onyebuchi A Arah, Kiki M J M H Lombarts
INTRODUCTION: Multisource feedback (MSF) instruments are used to and must feasibly provide reliable and valid data on physicians' performance from multiple perspectives. The "INviting Co-workers to Evaluate Physicians Tool" (INCEPT) is a multisource feedback instrument used to evaluate physicians' professional performance as perceived by peers, residents, and coworkers. In this study, we report on the validity, reliability, and feasibility of the INCEPT. METHODS: The performance of 218 physicians was assessed by 597 peers, 344 residents, and 822 coworkers...
February 15, 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28191378/mediterranean-spotted-fever-a-rare-non-endemic-disease-in-the-usa
#15
Joshua Brad Oaks, Glenmore Lasam, Gina LaCapra
We report a case of a 43-year-old Israeli male who presented with an intermittent fever associated with a gradual appearance of diffusely scattered erythematous non-pruritic maculopapular lesions, generalized body malaise, muscle aches, and distal extremity weakness. He works in the Israeli military and has been exposed to dogs that are used to search for people in tunnels and claimed that he had removed ticks from the dogs. In the hospital, he presented with fever, a diffuse maculopapular rash, and an isolated round black eschar...
January 12, 2017: Curēus
https://www.readbyqxmd.com/read/28190495/phenobarbital-or-potassium-bromide-as-an-add-on-antiepileptic-drug-for-the-management-of-canine-idiopathic-epilepsy-refractory-to-imepitoin
#16
E Royaux, L Van Ham, B J G Broeckx, I Van Soens, I Gielen, D Deforce, S F M Bhatti
Imepitoin has recently been approved in Europe for the management of dogs with idiopathic epilepsy. Currently, there is no evidence-based information available on the efficacy of antiepileptic drugs used as additions to the therapeutic regimen in dogs with idiopathic epilepsy that are not well controlled with imepitoin. The goal of this study was to evaluate the efficacy of phenobarbital or potassium bromide (KBr) as add-on antiepileptic drugs for controlling dogs refractory to a maximum dose of imepitoin (30 mg/kg twice daily)...
February 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28147595/evaluation-of-a-multiple-scattering-filter-to-enhance-defect-detection-in-heterogeneous-media
#17
Sharfine Shahjahan, Fabienne Rupin, Alexandre Aubry, Arnaud Derode
Ultrasonic evaluation of coarse-grain materials generates multiple scattering at high frequency and large depth. Recent academic experiments with array probes showed the ability of a random matrix method [multiple scattering filter (MSF)] to reduce multiple scattering, hence improving detection. Here, MSF is applied to an industrial nickel-based alloy with coarse-grain structure. Two samples with average grain sizes 90 ± 60 μm and 750 ± 400 μm are inspected with wide-band 64-element arrays at central frequencies 2, 3, and 5 MHz...
January 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28122533/offering-general-pediatric-care-during-the-hard-times-of-the-2014-ebola-outbreak-looking-back-at-how-many-came-and-how-well-they-fared-at-a-m%C3%A3-decins-sans-fronti%C3%A3-res-referral-hospital-in-rural-sierra-leone
#18
Veerle Hermans, Rony Zachariah, Desalegn Woldeyohannes, Gbessay Saffa, Dauda Kamara, Nimer Ortuno-Gutierrez, Walter Kizito, Marcel Manzi, Petra Alders, Jacob Maikere
BACKGROUND: In Bo district, rural Sierra Leone, we assessed the burden of the 2014 Ebola outbreak on under-five consultations at a primary health center and the quality of care for under-15 children at a Médecins Sans Frontières (MSF) referral hospital. METHODS: Retrospective cohort study, comparing a period before (May-October 2013) and during the same period of the Ebola outbreak (2014). Health worker infections occurred at the outbreak peak (October 2014), resulting in hospital closure due to fear of occupational-risk of contracting Ebola...
January 25, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28118828/clinical-evaluation-of-a-combination-therapy-of-imepitoin-with-phenobarbital-in-dogs-with-refractory-idiopathic-epilepsy
#19
Jasmin Neßler, Chris Rundfeldt, Wolfgang Löscher, Draginja Kostic, Thomas Keefe, Andrea Tipold
BACKGROUND: Imepitoin was tested as a combination treatment with phenobarbital in an open-label mono-centre cohort study in dogs with drug-resistant epilepsy. Diagnosis of idiopathic epilepsy was based on clinical findings, magnetic resonance imaging and cerebrospinal fluid analysis. Three cohorts were treated. In cohort A, dogs not responding to phenobarbital with or without established add-on treatment of potassium bromide or levetiracetam were treated add-on with imepitoin, starting at 10 mg/kg BID, with titration allowed to 30 mg/kg BID...
January 25, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28113766/single-scale-fusion-an-effective-approach-to-merging-images
#20
Codruta O Ancuti, Cosmin Ancuti, Christophe De Vleeschouwer, Alan C Bovik
Due to its robustness and effectiveness, multi-scale fusion based on the Laplacian pyramid decomposition has emerged as a popular technique that has shown utility in many applications. Guided by several intuitive measures (weight maps) the multi-scale fusion process is versatile and straightforward to be implemented. However, the number of pyramid levels increases with the image size, which implies sophisticated data management and memory accesses, as well as additional computations.. Here we introduce a simplified formulation that reduces multiscale fusion (MSF) to only a single level process...
October 26, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
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