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Lumbar puncture

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https://www.readbyqxmd.com/read/29907136/wilson-s-disease-combined-with-systemic-lupus-erythematosus-a-case-report-and-literature-review
#1
Yun Zhang, Dongmei Wang, Wei Wei, Xuejun Zeng
BACKGROUND: Wilson's disease (WD) is an inherited disorder in which defective biliary excretion of copper leads to its accumulation, particularly in the liver and brain. Systemic lupus erythematosus (SLE) is a multi-system disorder that can manifest in any system. Cases with concomitant WD and SLE, unrelated to treatment with penicillamine, have been rarely reported. CASE PRESENTATION: We report a case of a young woman who had typical neuropsychiatric symptoms and laboratory tests results of WD...
June 15, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29904315/nontypical-salmonella-meningitis-in-an-infant
#2
Thuy-My N Truong, Taryn N McGilvery, Tove M Goldson, Samuel N Forjuoh
A previously healthy 3-month-old girl was admitted to the hospital after 1 day of fever, decreased oral intake, irritability, lethargy, and decreased activity. Examination disclosed a bulging anterior fontanelle, tachycardia (heart rate of 160 beats/minute), and urate crystals in her diaper. Lumbar puncture revealed meningitis. She was treated with broad-spectrum antibiotics and fluids. A urine culture was negative, but blood and cerebrospinal fluid cultures came back positive for Salmonella species, nontyphoid...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29903588/rapid-effect-of-depletive-lumbar-puncture-on-papilledema-in-intracranial-hypertension
#3
T Abdellaoui, N Laaribi, G Bouayad, S Chatoui, F Elasri, K Reda, A Oubaaz
No abstract text is available yet for this article.
June 11, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29902603/endoscopic-endonasal-approach-to-the-gh-secreting-pituitary-adenomas-endocrinological-outcome-in-68-patients
#4
Mohammad Taghvaei, Seyed Mousa Sadrehosseini, Javad Behjati Ardakani, Manouchehr Nakhjavani, Mehdi Zeinalizadeh
PURPOSE: Endoscopic endonasal approach has recently become an acceptable option for resection of all pituitary adenomas. We assessed biochemical outcome of endoscopic endonasal surgery in growth hormone (GH) secreting adenomas including remission rate, predictors of remission and associated complications. METHODS: Sixty eight consecutive patients with acromegaly who underwent endoscopic endonasal surgery have been analyzed prospectively. Tumors were classified according to the size, Knosp score and Hardy-Wilson classifications...
June 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29901586/eosinophilic-meningitis-caused-by-angiostrongylus-cantonensis-in-an-infant-a-case-report
#5
Mingsheng Ma, Mengqi Zhang, Zhengqing Qiu
RATIONALE: Parasitic eosinophilic meningitis is rarely observed in infants. The diagnosis of this disease is complicated by its atypical and severe clinical manifestations. PATIENT CONCERNS: An infant presented to our hospital with high fever and irritability, as well as refusal to walk. Cerebrospinal fluid collected through lumbar puncture showed increased eosinophil count and third-stage Angiostrongylus cantonensis larvae. DIAGNOSES: Eosinophilic meningitis was suspected...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29899987/-streptococcus-pyogenes-and-invasive-central-nervous-system-infection
#6
Ekamjeet Randhawa, John Woytanowski, Kedesha Sibliss, Ian Sheffer
Streptococcus pyogenes is a Gram-positive beta-hemolytic bacteria, also known as group A streptococci, that causes a range of infections. The most common presentation is acute pharyngitis; however, it is also implicated in skin and soft tissue infections, and less commonly bacteremia, osteomyelitis, pneumonia, otitis media and sinusitis. Group A streptococci infections of the central nervous system are exceedingly rare in the antibiotic era. The mechanism of infection is typically contiguous spread from existing infection or via direct inoculation...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29891731/local-bdnf-delivery-to-the-injured-cervical-spinal-cord-using-an-engineered-hydrogel-enhances-diaphragmatic-respiratory-function
#7
Biswarup Ghosh, Zhicheng Wang, Jia Nong, Mark W Urban, Zhiling Zhang, Victoria A Trovillion, Megan C Wright, Yinghui Zhong, Angelo C Lepore
We developed an innovative biomaterial-based approach to repair the critical neural circuitry that controls diaphragm activation by locally delivering brain-derived neurotrophic factor (BDNF) to injured cervical spinal cord. BDNF can be used to restore respiratory function via a number of potential repair mechanisms; however, widespread BDNF biodistribution resulting from delivery methods such as systemic injection or lumbar puncture can lead to inefficient drug delivery and adverse side effects. As a viable alternative, we developed a novel hydrogel-based system loaded with polysaccharide-BDNF particles self-assembled by electrostatic interactions that can be safely implanted in the intrathecal space for achieving local BDNF delivery with controlled dosing and duration...
June 11, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29891509/raised-intracranial-pressure-with-bilateral-anterior-uveitis
#8
Ivan Yeu Ming Yip, Stephen Scotcher
We report the rare case of a 5-year-old boy with an infective cause of papilloedema and bilateral uveitis secondary to Mycoplasma pneumoniae The patient presented with generalised headache and malaise. MRI showed signs of raised intracranial pressure and lumbar puncture opening pressure was 43 cmH2 O.Lumbar puncture did not reveal any infective organisms. Blood tests showed raised inflammatory markers. The patient was started on prednisolone, acetazolamide and intravenous cefotaxime. Following an improvement, the patient was discharged...
June 10, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29888305/evidence-for-altered-brain-reactivity-to-norepinephrine-in-veterans-with-a-history-of-traumatic-stress
#9
Rebecca C Hendrickson, Murray A Raskind, Steven P Millard, Carl Sikkema, Garth E Terry, Kathleen F Pagulayan, Ge Li, Elaine R Peskind
Background: Increases in the quantity or impact of noradrenergic signaling have been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). This increased signaling may result from increased norepinephrine (NE) release, from altered brain responses to NE, or from a combination of both factors. Here, we tested the hypothesis that Veterans reporting a history of trauma exposure would show an increased association between brain NE and mental health symptoms commonly observed after trauma, as compared to Veterans who did not report a history of trauma exposure, consistent with the possibility of increased brain reactivity to NE after traumatic stress...
February 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/29886166/attenuation-of-the-degenerative-effects-of-endothelin-1-on-cartilaginous-endplate-cells-by-the-endothelin-receptor-antagonist-bq-123-via-the-wnt-%C3%AE-catenin-signaling-pathway
#10
Wei Yuan, Zhen-Xi Li, Cheng-Long Zhao, Tian-Hui Hou, Si-Wang Hu, Wei-Bo Liu, Feng-Lai Yuan, Jian-Ru Xiao
BACKGROUND: Context: Endothelin-1 (ET-1) is an inflammatory mediator associated with cartilage endplate (CEP) degeneration in the intervertebral disc. SOX9 is down-regulated during CEP degeneration, along with its targets, collagen II and aggrecan. Wnt/β-catenin signaling is associated with CEP degeneration and a downstream target of SOX9; however, the precise mechanism of CEP degeneration and the role of ET-1 are largely unknown. PURPOSE: The purpose of the study was to evaluate the influence of the endothelin A receptor antagonist, BQ-123, on ET-1-induced effects on cartilaginous endplate cells (CECs) associated with CEP degeneration via the Wnt/β-catenin signaling pathway...
June 7, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29886163/dynamic-adaptation-of-vertebral-endplate-and-trabecular-bone-following-annular-injury-in-a-rat-model-of-degenerative-disc-disease
#11
Tristan Maerz, Michael Newton, Abigail A Marek, Michael Planalp, Kevin Baker
BACKGROUND/CONTEXT: Degenerative disc disease (DDD) is associated with longitudinal remodeling of paravertebral tissues. While chronic vertebral changes in advanced stages of DDD are well-studied, very little data exists on acute vertebral bone remodeling at the onset and progression of DDD. PURPOSE: To longitudinally characterize bony remodeling in a rodent model of disc injury-induced DDD. STUDY DESIGN/SETTING: In vivo animal study involving a rat annulus fibrosus injury model of DDD...
June 7, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29883235/the-intraocular-pressure-could-not-be-used-to-determine-the-intracranial-pressure-in-patients-with-hydrocephalus
#12
Wei Wang, Maode Wang, Zhijin Li, Tuo Wang, Rong Da
PURPOSE: An accurate intracranial pressure (ICP) measurement is vital for patients with hydrocephalus. ICP is generally measured by lumbar puncture opening pressure, which is invasive and has potential adverse side effects. Intraocular pressure (IOP) was investigated to measure ICP indirectly; however, its accuracy was controversial. We conducted this retrospective study to investigate whether IOP can be used as a surrogate for ICP in hydrocephalus patients. METHODS: We performed a retrospective study enrolled 50 cases, including 32 patients with normal pressure hydrocephalus (NPH) and 18 patients with high pressure hydrocephalus (HPH)...
June 8, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29878345/headache-and-ophthalmoparesis-case-report-of-an-atypical-incomplete-miller-fisher-syndrome
#13
David Moreno-Ajona, Pablo Irimia, Marta Fernández-Matarrubia
OBJECTIVE: To expand the differential diagnosis of headache and ophthalmoparesis by describing a case report in which anti-GQ1b was demonstrated to be the cause. BACKGROUND: Anti-GQ1b antibody syndrome refers to a clinical spectrum of conditions that share common mechanisms and overlapping manifestations, including the Miller-Fisher syndrome, pharyngeal-cervical-brachial weakness, and Bickerstaff brainstem encephalitis. Rare atypical cases presenting as acute ophthalmoparesis (AO) without ataxia or areflexia have been described...
May 2018: Headache
https://www.readbyqxmd.com/read/29873738/evaluating-circulating-tumor-dna-from-the-cerebrospinal-fluid-of-patients-with-melanoma-and-leptomeningeal-disease
#14
Leomar Y Ballester, Isabella C Glitza Oliva, Dzifa Y Douse, Melissa M Chen, Chieh Lan, Lauren E Haydu, Jason T Huse, Sinchita Roy-Chowdhuri, Rajyalakshmi Luthra, Ignacio I Wistuba, Michael A Davies
Circulating tumor DNA (ctDNA) refers to tumor-derived cell-free DNA that circulates in body fluids. Fluid samples are easier to collect than tumor tissue, and are amenable to serial collection at multiple time points during the course of a patient's illness. Studies have demonstrated the feasibility of performing mutation profiling from blood samples in cancer patients. However, detection of ctDNA in the blood of patients with brain tumors is suboptimal. Cerebrospinal fluid (CSF) can be obtained via lumbar puncture or intraventricular catheter, and may be a suitable fluid to assess ctDNA in patients with brain tumors...
June 4, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29871901/increased-detection-of-human-parechovirus-infection-in-infants-in-england-during-2016-epidemiology-and-clinical-characteristics
#15
Laura Ferreras Antolín, Seilesh Kadambari, Serena Braccio, Julian Wei-Tze Tang, Jacqueline Xerry, David James Allen, Shamez N Ladhani
BACKGROUND: Human parechovirus (HPeV), like enteroviruses, usually causes mild self-limiting respiratory and gastrointestinal symptoms. In infants, HPeV can occasionally cause serious illnesses, including sepsis-like syndrome and encephalitis. In summer 2016, Public Health England (PHE) received increasing reports of severe HPeV infections nationally. We, therefore, reviewed all infants with confirmed HPeV across England during 2016. METHODS: HPeV cases in infants aged <12 months reported to PHE during 2016 were followed up using a clinical questionnaire...
June 5, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29871381/volume-navigation-with-fusion-of-real-time-ultrasound-and-ct-images-to-guide-posterolateral-transforaminal-puncture-in-percutaneous-endoscopic-lumbar-discectomy
#16
Yan-Bin Liu, Yin Wang, Zi-Qiang Chen, Jun Li, Wei Chen, Chuan-Feng Wang, Qiang Fu
BACKGROUND: The use of percutaneous endoscopic lumbar discectomy (PELD) is increasing in the treatment of lumbar disc herniations (LDH). Nerve and vessel injury may happen during the establishment of the transforaminal working channel. Also, there is usually exposure to intraop radiation when the C-arm is used to help establish the location of the transforaminal working channel. OBJECTIVE: To evaluate the accuracy and safety of the volume navigation technique for guiding transforaminal puncture in cadaver and clinical patient treatment...
May 2018: Pain Physician
https://www.readbyqxmd.com/read/29870652/a-case-with-reversible-neurotoxicity-induced-by-metronidazole
#17
Fulya Eren, Mehmet Ali Aldan, Vasfiye Burcu Dogan, Günay Gül, Hakan Hatem Selcuk, Aysun Soysal
Background - Metronidazole is a synthetic antibiotic, which has been commonly used for protozoal and anaerobic infections. It rarely causes dose - and duration - unrelated reversible neurotoxicity. It can induce hyperintense T2/FLAIR MRI lesions in several areas of the brain. Although the clinical status is catastrophic, it is completely reversible after discontinuation of the medicine. Case report - 36-year-old female patient who had recent brain abscess history was under treatment of metronidazole for 40 days...
November 30, 2017: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29870024/recurrent-branch-retinal-artery-occlusion-from-susac-syndrome-case-report-and-review-of-literature
#18
Michael J Ammar, Anton M Kolomeyer, Nirali Bhatt, Madhura A Tamhankar, Michael T Mullen, Alexander J Brucker
PURPOSE: We report a patient with branch retinal artery occlusion predominant Susac syndrome and review the literature on current diagnostic modalities and therapeutic approaches for this rare condition. METHODS: Case report. RESULTS: A 23-year-old white male presented with a 5-month history of a scotoma in his right eye vision, headaches, and intermittent paresthesias of the lower extremities. Ophthalmic examination was normal with the exception of a hypopigmented small retinal area inferonasal to the fovea in the right eye...
May 30, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29869434/computed-tomography-head-scans-prior-to-lumbar-punctures-in-suspected-meningitis
#19
Aqilah Imtiaz, Robyn Toomath
The literature suggests that certain clinical criteria to determine raised intracranial pressure should be met if a patient suspected of meningitis is to undergo a computed tomography (CT) head scan prior to having a lumbar puncture (LP). The purpose of this audit was to evaluate whether these criteria were being used by the general medicine department of Auckland City Hospital when requesting CT scans prior to LPs in patients with suspected meningitis. A total of 37 patients admitted under general medicine with suspected meningitis from January 1st to July 31st 2016 were retrospectively audited based on the clinical evidence justifying the decision to do a CT scan prior to an LP...
June 5, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29868327/surgical-outcomes-and-postoperative-management-in-spontaneous-cerebrospinal-fluid-rhinorrhea
#20
Zi Yang Jiang, Caitlin McLean, Carlos Perez, Samuel Barnett, Deborah Friedman, Bobby A Tajudeen, Pete S Batra
Background  The etiology of spontaneous cerebrospinal fluid (CSF) rhinorrhea remains unknown, though emerging evidence suggests that this likely represents a variant of idiopathic intracranial hypertension. Long-term success rates for repair and postoperative management strategies remain variable. Methods  Retrospective review of patients undergoing surgical management of spontaneous CSF rhinorrhea was conducted over a 5-year period. Analysis was performed to correlate recurrence with demographics and perioperative variables...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
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