keyword
MENU ▼
Read by QxMD icon Read
search

Emergency headache

keyword
https://www.readbyqxmd.com/read/29913017/safety-and-tolerability-of-multiple-ascending-doses-of-prx002-rg7935-an-anti-%C3%AE-synuclein-monoclonal-antibody-in-patients-with-parkinson-disease-a-randomized-clinical-trial
#1
Joseph Jankovic, Ira Goodman, Beth Safirstein, Tonya K Marmon, Dale B Schenk, Martin Koller, Wagner Zago, Daniel K Ness, Sue G Griffith, Michael Grundman, Jay Soto, Susanne Ostrowitzki, Frank G Boess, Meret Martin-Facklam, Joseph F Quinn, Stuart H Isaacson, Omid Omidvar, Aaron Ellenbogen, Gene G Kinney
Importance: Aggregated α-synuclein is believed to be central to the pathogenesis of Parkinson disease (PD). PRX002/RG7935 (PRX002) is a humanized monoclonal antibody designed to target aggregated forms of α-synuclein, thereby inhibiting neuron-to-neuron transfer of presumed pathogenic forms of α-synuclein, potentially resulting in neuronal protection and slowing disease progression. Objective: To evaluate the safety and tolerability of multiple intravenous infusions of PRX002 in patients with idiopathic PD...
June 18, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29912786/a-12-month-open-label-extension-study-of-the-safety-and-tolerability-of-lisdexamfetamine-dimesylate-for-major-depressive-disorder-in-adults
#2
Cynthia Richards, Dan V Iosifescu, Rajnish Mago, Elias Sarkis, Brooke Geibel, Matthew Dauphin, Roger S McIntyre, Richard Weisler, Olga Brawman-Mintzer, Joan Gu, Manisha Madhoo
PURPOSE/BACKGROUND: Psychostimulant augmentation is considered a potential treatment strategy for individuals with major depressive disorder who do not adequately respond to antidepressant monotherapy. The primary objective of this 12-month open-label extension study was to evaluate the safety and tolerability of lisdexamfetamine dimesylate (LDX) as augmentation therapy to an antidepressant in adults with major depressive disorder. METHODS/PROCEDURES: Eligible adults who completed 1 of 3 short-term antecedent LDX augmentation of antidepressant monotherapy studies were treated with dose-optimized LDX (20-70 mg) for up to 52 weeks while continuing on the index antidepressant (escitalopram, sertraline, venlafaxine extended-release, or duloxetine) assigned during the antecedent short-term studies...
June 16, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912084/ibuprofen-for-pain-control-in-children-new-value-for-an-old-molecule
#3
Dimitri Poddighe, Ilaria Brambilla, Amelia Licari, Gian Luigi Marseglia
BACKGROUND: Acute pain is one of the major complaints reported in pediatric emergency departments and general wards. Recently, both the US Food and Drug Administration and European Medicine Agency emitted some warnings regarding the use of opioids, including codeine, in children. OBJECTIVE: The aims of this study were summarizing the main pharmacological aspects of ibuprofen, discussing the current evidence about the use of ibuprofen in different and specific clinical settings, and providing a comparison with acetaminophen and/or codeine, according to available studies...
June 14, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29912006/zika-virus-infection-and-differential-diagnosis-in-a-cohort-of-hiv-infected-patients
#4
Guilherme Amaral Calvet, Patricia Brasil, Andre Machado Siqueira, Heruza Einsfeld Zogbi, Bianca de Santis Gonçalves, Aline da Silva Santos, Otilia Lupi, Rogerio Valls de Souza, Cintia Damasceno Dos Santos Rodrigues, Clarisse da Silveira Bressan, Mauymi Duarte Wakimoto, Eliane Saraiva de Araújo, Ingrid Cardoso Dos Santos, Ingebourg Georg, Rita Maria Ribeiro Nogueira, Valdilea Gonçalves Veloso, Ana Maria Bispo de Filippis
BackgroundZika virus (ZIKV) emergence in South America revealed the lack of knowledge regarding clinical manifestations in HIV-infected individuals. OBJECTIVES: We described the clinical characteristics, laboratory manifestations, differential diagnosis, and outcome of ZIKV infection in a large, single-center cohort of HIV-infected patients.MethodsHIV-infected patients aged ≥ 18 years with clinical suspected arboviral disease from an ongoing cohort were followed from February through December 2015...
June 14, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29911576/symptoms-disabilities-and-life-satisfaction-five-years-after-whiplash-injuries
#5
Johan Styrke, Peter Sojka, Ulf Björnstig, Britt-Marie Stålnacke
Background Chronic whiplash-associated disorders (WADs) are often associated with social functioning problems and decreased ability to perform previous activities. This may lead to decreased life satisfaction, which is insufficiently studied in the context of whiplash injuries. Symptoms included in chronic WAD are similar to symptoms frequently reported by persons who have sustained mild traumatic brain injury (MTBI)/concussion. In cases of MTBI, the severity and number of symptoms have been suggested to have a diagnostic value...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29908647/emergency-department-use-of-neuroimaging-in-children-and-adolescents-presenting-with-headache
#6
Meghan R Cain, Dimitrios Arkilo, Amy M Linabery, Anupam B Kharbanda
OBJECTIVES: To evaluate emergency department use and outcomes of neuroimaging for headache in a free-standing children's hospital system. STUDY DESIGN: We prospectively enrolled children aged 6-18 years who presented to the emergency department with a chief complaint of headache from September 2015 to September 2016. Standardized data collection was performed in real time, including telephone follow-up as needed, and imaging outcome was determined through a chart review...
June 14, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29906040/atypical-clinical-presentation-of-flavivirus-case-report
#7
Rodrigo Gopar-Nieto, Nancy Libertad Chávez-Gómez, María Elisa González-Rentería, Luis Adrián Estrada-Loyo, Roberto de Jesús García-Avilés, Carlos Lenin Pliego-Reyes
The first report of chikungunya virus (CHIKV) in Mexico was in may 2014, in Jalisco, and has disseminated along the country in such a way that now is considered a relevant emergent vector-transmitted infection. It is clinically diagnosed by abrupt onset fever, asthenia, arthralgias, myalgias, headache and rash. In the clinical case, we described a women from Guerrero that had pulmonary symptomatology associated to CHIKV, which is an atypical clinical presentation that has been reported only in a hundred cases worldwide...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29906034/schmidt%C3%A2-s-syndrome-a-difficult-diagnosis-in-the-latin-american-context
#8
Claudia Barreda-Velit, Rodrigo Salcedo-Pereda, Jesús Ticona
Background: Schmidt’s syndrome, also known as poliglandular autoimmune syndrome type 2, is a rare disease that has a prevalence between 1.5-4.5 cases per 100 000 inhabitants. The diagnosis consists in the concomitant presentation of Addison disease, autoimmune thyroid disease and other autoimmune endocrinological conditions. The aim of this paper is to describe a case of Schmidt’s syndrome in the peruvian context and to analyze the difficulties in the diagnosis. Clinical case: We present the case of a 43-year-old woman that presents to the emergency room with headache, nausea, vomits and a “syncope episode”...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29905976/pharmacokinetics-safety-and-tolerability-of-rolapitant-administered-intravenously-following-single-ascending-and-multiple-ascending-doses-in-healthy-subjects
#9
Xiaodong Wang, Zhi-Yi Zhang, Jing Wang, Dan Powers, Sujata Arora, Sharon Lu, Vikram Kansra
Rolapitant is a selective and long-acting neurokinin-1 receptor antagonist approved in an oral formulation in combination with dexamethasone and a 5-hydroxytryptamine type 3 receptor antagonist for the prevention of delayed chemotherapy-induced nausea and vomiting in adults. The pharmacokinetic and safety profiles of intravenous (IV) rolapitant were evaluated in two open-label, phase 1 trials in healthy subjects. Single ascending dose (SAD) and multiple ascending dose studies were conducted in one trial (PR-11-5012-C), and a supratherapeutic SAD study was conducted in a separate trial (PR-11-5022-C)...
June 15, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29904851/headache-in-the-emergency-department-the-role-of-imaging
#10
Carla Uggetti, Katia Khouri Chalouhi, Silvia Squarza, Fabio Frediani, Maurizio Cariati
No abstract text is available yet for this article.
June 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29904802/an-update-on-repetitive-transcranial-magnetic-stimulation-for-the-treatment-of-co-morbid-pain-and-depressive-symptoms
#11
REVIEW
Jonathan H Hsu, Zafiris J Daskalakis, Daniel M Blumberger
PURPOSE: Review recent meta-analyses and clinical trials investigating the therapeutic use of repetitive transcranial magnetic stimulation (rTMS) for concurrent pain and depressive symptoms. RECENT FINDINGS: Recent meta-analyses have included both pain and depression outcomes in fibromyalgia and chronic pain. Randomized controlled trials have also been conducted in post-herpetic neuralgia, trauma-related headache, and neuropathic pain with attention to both pain and depressive symptoms...
June 14, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29891122/a-non-traumatic-rapid-onset-headache-that-is-as-dangerous-as-subarachnoid-hemorrhage-sah-seen-in-the-emergency-department
#12
Matthew M Palilonis, Jeanne L Jacoby
No abstract text is available yet for this article.
May 30, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29888727/the-value-of-bedside-ocular-ultrasound-assessment-of-optic-nerve-sheath-diameter-in-the-detection-of-increased-intracranial-pressure-in-patients-presenting-to-the-emergency-room-with-headache
#13
Y Canakci, O Koksal, V A Durak
Introduction: Headache is one of the most important complaints in emergency room (ER) admissions, and the rate of the increase in intracranial pressure in these cases should not be overlooked. This study was performed to investigate the value of the measurement of optic nerve sheath diameter (ONSD) by ocular ultrasound in ER patients with the complaint of headache and increase in intracranial pressure regarding this. Materials and Methods: : A total of 100 patients who applied to the ER with the complaint of headache were included in this prospective study...
June 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29881656/somatosensory-evoked-potentials-as-a-tool-to-evaluate-brainstem-herniation-in-the-neuroscience-intensive-care-unit
#14
Nakul Katyal, Christopher R Newey, Pravin George, Premkumar Nattanamai, Jonathan M Beary, Agnieszka Ardelt, Anantha Vellipuram
Somatosensory evoked potentials (SSEPs) are a sensitive, minimally invasive technique used to localize dysfunction of myelinated peripheral and central axons in the nervous system. The utility of SSEPs in acutely assessing central nervous system function in brainstem herniation in the neuroscience intensive care unit (NICU) has not been well established. We discuss a case of an 18-year-old, postpartum female who presented with intermittent headache, diplopia, nausea/vomiting and cachexia following delivery two months prior...
April 6, 2018: Curēus
https://www.readbyqxmd.com/read/29881652/migraine-treatment-in-the-emergency-department-alternatives-to-opioids-and-their-effectiveness-in-relieving-migraines-and-reducing-treatment-times
#15
REVIEW
Haley Dodson, Jay Bhula, Sven Eriksson, Khoa Nguyen
The objective of this literature review is to evaluate the efficacy of opioids for the treatment of headaches, particularly migraines, in the emergency department (ED). Despite safer alternatives, opiates are routinely used as an abortive treatment for migraine headaches. The studies reviewed demonstrate that opiates are less effective in terminating acute headaches and result in prolonged ED visits. Dopamine receptor antagonists, such as metoclopramide and prochlorperazine, were the most efficacious in terminating migraines in the studies examined...
April 6, 2018: Curēus
https://www.readbyqxmd.com/read/29878341/dfn-02-sumatriptan-10-mg-with-a-permeation-enhancer-nasal-spray-vs-placebo-in-the-acute-treatment-of-migraine-a-double-blind-placebo-controlled-study
#16
Richard B Lipton, Sagar Munjal, Elimor Brand-Schieber, Alan M Rapoport
OBJECTIVE: The objective of this study was to evaluate the efficacy, safety, and tolerability of DFN-02 - a nasal spray comprising sumatriptan 10 mg and a permeation-enhancing excipient (0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside [DDM]) - for the acute treatment of migraine with or without aura in adults. BACKGROUND: Prior work has shown that DFN-02, which contains only half the recommended adult dose of sumatriptan found in the original formulation (10 mg vs 20 mg), is more rapidly absorbed than commercial nasal spray of sumatriptan, with favorable pharmacokinetic and safety profiles...
May 2018: Headache
https://www.readbyqxmd.com/read/29876334/pneumocephalus-after-tympanomastoidectomy-a-case-presentation
#17
Mohammadhossein Baradaranfar, Sedighe Vaziribozorg, Mojtaba Mirzade, Mostafa Salari
Introduction: Pneumocephalus is the presence of air or gas within the cranial cavity. It can occur following otorhinolaryngological procedures. A small pneumocephalus spontaneously heals without any treatment. In severe cases, conservative therapy includes a 30-degree head elevation, avoidance of the Valsalva maneuver, analgesics, osmotic diuretics, and oxygen therapy. Case Report: A 56-year-old woman was referred to the emergency department due to a severe headache in the frontal area for 2 days before admission...
May 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29875920/-hemorrhagic-rupture-of-a-giant-arteriovenous-malformation-in-a-young-man-in-ouagadougou
#18
Anselme Alfred Dabilgou, Julie Marie Adeline Kyelem
Vascular arteriovenous malformations (VAM) are aggressive vascular diseases associated with increased haemorrhagic risk in terms of morbidity and mortality. Vascular arteriovenous malformations are usually sporadic. The main symptom of VAM is hemorrhage, in 50% of cases. We here report the case of a 28 year old patient, hospitalized with right sided motor deficit of acute onset associated with consciousness disorder in the Department of Neurology at the Yalgado Ouédraogo University Hospital Center. The patient had a history of chronic headaches treated with self-medication and of right Bravais-Jacksonian seizures...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29875859/posterior-reversible-encephalopathy-syndrome-as-a-postpartum-complication
#19
Samra Kadić-Vukas, Mirsada Hodžić, Lejla Tandir-Lihić, Lejla Hrvat, Azra Kožo-Kajmaković, Nina Kuzmanović, Haris Vukas
BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiological syndrome with seizures, altered consciousness, visual disturbances and headache among other symptoms. Hinchey et al. first described Pres in 1996, with two other case series published shortly after. CASE REPORT: A 23-year-old women patient was emergency sent from General Hospital Tešanj due to a crisis of consciousness and repeated epileptic seizures. The patient had a second birth before 10 days (postpartum cesarean) in general endotracheal anaesthesia (two cesarean-born babies)...
May 20, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29874930/red-flag-findings-in-children-with-headaches-prevalence-and-association-with-emergency-department-neuroimaging
#20
Daniel S Tsze, Julie B Ochs, Ariana E Gonzalez, Peter S Dayan
Background Clinicians appear to obtain emergent neuroimaging for children with headaches based on the presence of red flag findings. However, little data exists regarding the prevalence of these findings in emergency department populations, and whether the identification of red flag findings is associated with potentially unnecessary emergency department neuroimaging. Objectives We aimed to determine the prevalence of red flag findings and their association with neuroimaging in otherwise healthy children presenting with headaches to the emergency department...
January 1, 2018: Cephalalgia: An International Journal of Headache
keyword
keyword
14634
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"