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https://www.readbyqxmd.com/read/29442229/long-term-safety-and-efficacy-of-guanfacine-extended-release-in-children-and-adolescents-with-adhd
#1
Michael Huss, Bryan Dirks, Joan Gu, Brigitte Robertson, Jeffrey H Newcorn, J Antoni Ramos-Quiroga
Data are reported from SPD503-318, a phase 3, open-label, safety study of guanfacine extended release (GXR) in European children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Participants received dose-optimized GXR (1-7 mg/day) for up to 2 years. Of 215 enrolled participants, 214 were included in the safety population and 133 completed the study. Participants' mean age was 11.7 years and 73.8% were male. Overall, 177 participants (82.7%) experienced a treatment-emergent adverse event (TEAE)...
February 13, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29441490/zika-virus-outbreak-a-review-of-neurological-complications-diagnosis-and-treatment-options
#2
REVIEW
Veerendra Koppolu, T Shantha Raju
Zika virus (ZIKV) is an arbovirus transmitted mainly by mosquitos of Aedes species. The virus has emerged in recent years and spread throughout North and South Americas. The recent outbreak of ZIKV started in Brazil (2015) has resulted in infections surpassing a million mark. Contrary to the previous beliefs that Zika causes mildly symptomatic infections fever, headache, rash, arthralgia, and conjunctivitis, the recent outbreak associated ZIKV to serious neurological complications such as microcephaly, Guillain-Barré syndrome, and eye infections...
February 13, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29438129/central-and-peripheral-processes-in-headache
#3
Adithya Varma, Saurabh Jain, Arshad Majid, Milena De Felice
PURPOSE OF REVIEW: Migraine is an extremely incapacitating collection of neurological symptoms that usually includes a severe, throbbing, recurring pain on one side of the head. The World Health Organization ranks migraine as the third most prevalent disease and the seventh commonest primary pain condition in the world. Trigeminovascular-mediated central sensitization has been implicated in the development of migraine symptoms including pain following light touch. This review explores the activation and sensitization of the brain systems that have emerged from recent studies and that contribute to migraine...
February 12, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29437311/sudden-headache-lumbar-puncture-and-the-diagnosis-of-subarachnoid-hemorrhage-in-patients-with-a-normal-computed-tomography-scans
#4
Joaquín Valle Alonso, Francisco Javier Fonseca Del Pozo, Manuel Vaquero Álvarez, Juan José De la Fuente Carillo, José Carlos Llamas, Yelda Hernández Montes
OBJECTIVES: To assess the usefulness of computed tomography (CT) to identify subarachnoid bleeding in patients with neurologic deficits seeking emergency care for sudden headache within 6 hours of onset of symptoms. MATERIAL AND METHODS: Retrospective observational study of patients presenting with sudden nontraumatic headache peaking during the previous hour in the absence of neurologic deficits. We ordered CT scans for all patients, and if the scan was normal we performed a lumbar puncture...
February 2018: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
https://www.readbyqxmd.com/read/29435715/clinical-chameleons-an-emergency-medicine-focused-review-of-carbon-monoxide-poisoning
#5
REVIEW
Patrick Chow Yuen Ng, Brit Long, Alex Koyfman
Carbon monoxide (CO) is a colorless, odorless gas that is found in the environment, in the home, and in the human body as a normal part of mammalian metabolism. Poisoning from CO, a common exposure, is associated with significant morbidity and mortality if not recognized and treated in a timely manner. This review evaluates the signs and symptoms of CO poisoning, conditions that present similar to CO poisoning, and an approach to the recognition and management for CO poisoning. CO poisoning accounts for thousands of emergency department visits annually...
February 12, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29433934/evidence-based-review-of-pharmacotherapy-for-acute-agitation-part-2-safety
#6
Leslie S Zun
BACKGROUND: The management of acute agitation in the emergency department often requires the administration of rapid-acting antipsychotic agents. However, there are few comparative studies and little guidance regarding the risks associated with use of such drugs in the acute setting. OBJECTIVE: This structured evidence-based review compared the safety of antipsychotic pharmacotherapies for acute agitation using data from randomized controlled trials identified by a literature search of the PubMed database...
February 9, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29433507/sudden-spleen-rupture-in-a-plasmodium-vivax-infected-patient-undergoing-malaria-treatment
#7
Aleix Elizalde-Torrent, Fernando Val, Ingrid Cardoso C Azevedo, Wuelton M Monteiro, Luiz C L Ferreira, Carmen Fernández-Becerra, Hernando A Del Portillo, Marcus V G Lacerda
BACKGROUND: Splenomegaly is one of the most common features of malaria. However, spontaneous splenic rupture, although unusual, represents a severe complication often leading to death. It is mostly seen in acute infection and primary attack, and it is most commonly associated with Plasmodium vivax. Here, a case of spontaneous splenic rupture diagnosed with a portable ultrasound apparatus shortly after starting treatment and with recurrent parasitaemia after splenectomy, is reported. CASE DESCRIPTION: In November 2015, a 45-year-old Brazilian man presented to the hospital in Manaus with fever, headache and myalgia...
February 13, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29428262/intracranial-hemorrhage-as-initial-manifestation-of-plasma-cell-myeloma-a-case-report
#8
Jonathan G Hobbs, Charles Van Slambrouck, Jonathan L Miller, Bakhtiar Yamini
This is the case of a previously healthy 48 year-old male whom presented with mild confusion, low-grade headache, and left sided weakness. Computed tomography of the head revealed a large acute right frontal lobe intracranial hemorrhage (ICH) and intraventricular extension, with normal vascular imaging. Initial laboratory testing was inconsequential. The patient required emergent evacuation, with pathology revealing only elements of a hematoma. Further laboratory testing and bone marrow biopsy results confirmed the diagnosis of plasma cell myeloma...
February 7, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29417135/efficacy-and-safety-of-guselkumab-an-anti-interleukin-23-monoclonal-antibody-for-palmoplantar-pustulosis-a-randomized-clinical-trial
#9
Tadashi Terui, Satomi Kobayashi, Yukari Okubo, Masamoto Murakami, Keiichiro Hirose, Hiroshi Kubo
Importance: Palmoplantar pustulosis (PPP) is a recalcitrant skin disease with no biologics currently approved for treatment. The involvement of interleukin 23 (IL-23) and cytokines of the type 17 helper T cell lineage in the pathogenesis of PPP has been recently postulated. Objective: To evaluate the efficacy and safety of guselkumab, an anti-IL-23 monoclonal antibody, in Japanese patients with PPP. Design, Setting, and Participants: This double-blind, randomized, placebo-controlled, parallel-group, 24-week trial was conducted between May 14, 2013, and September 27, 2014, at 11 centers in Japan...
February 7, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29416338/oxidative-antioxidative-status-lymphocyte-dna-damage-and-urotensin-2-receptor-level-in-patients-with-migraine-attacks
#10
Mehmet Yigit, Ozgur Sogut, Özlem Tataroglu, Adnan Yamanoglu, Eda Yigit, Eray Metin Güler, Omer Faruk Ozer, Abdurrahim Kocyigit
Background: The present study investigated the potential roles of plasma lymphocyte DNA damage, the urotensin-2 receptor (UTS2R), and oxidative changes in patients with varying degrees of migraine-related disability who were in the ictal phase and presented to our emergency department. Methods: This study enrolled 40 consecutive adult patients with migraine attack and 40 age- and sex-matched healthy controls. The same health care professional determined the headache-related disability of each patient's migraine attack using the Migraine Disability Assessment Scale (MIDAS); patients were divided into three groups based on MIDAS score...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29415258/a-long-term-open-label-study-to-evaluate-the-safety-and-tolerability-of-brexpiprazole-as-maintenance-treatment-in-adults-with-schizophrenia
#11
Andy Forbes, Mary Hobart, John Ouyang, Lily Shi, Stephanie Pfister, Mika Hakala
Background: Brexpiprazole is a serotonin-dopamine activity modulator with efficacy in acute schizophrenia and relapse prevention. The aim of this Phase 3, multicenter study was to assess the long-term safety, tolerability, and efficacy of treatment with brexpiprazole flexible-dose 1-4 mg/day. Methods: Patients rolled over into this 52-week open-label study (amended to 26 weeks towards the end) from three randomized, double-blind, placebo-controlled Phase 3 studies...
February 3, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29406201/proton-pump-inhibitors-review-of-emerging-concerns
#12
REVIEW
Avinash K Nehra, Jeffrey A Alexander, Conor G Loftus, Vandana Nehra
First introduced in 1989, proton pump inhibitors (PPIs) are among the most widely utilized medications worldwide, both in the ambulatory and inpatient clinical settings. The PPIs are currently approved by the US Food and Drug Administration for the management of a variety of gastrointestinal disorders including symptomatic peptic ulcer disease, gastroesophageal reflux disease, and nonulcer dyspepsia as well as for prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy. PPIs inhibit gastric acid secretion, and the most commonly associated adverse effects include abdominal pain, diarrhea, and headache...
February 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29404713/long-term-study-of-the-efficacy-and-safety-of-onabotulinumtoxina-for-the-prevention-of-chronic-migraine-compel-study
#13
Andrew M Blumenfeld, Richard J Stark, Marshall C Freeman, Amelia Orejudos, Aubrey Manack Adams
BACKGROUND: OnabotulinumtoxinA is approved for the prevention of headache in those with chronic migraine (CM); however, more clinical data on the risk-benefit profile for treatment beyond one year is desirable. METHODS: The Chronic Migraine OnabotulinuMtoxinA Prolonged Efficacy open Label (COMPEL) Study ( ClinicalTrials.gov , NCT01516892) is an international, multicenter, open-label long-term prospective study. Adults with CM received 155 U of onabotulinumtoxinA (31 sites in a fixed-site, fixed-dose paradigm across 7 head/neck muscles) every 12 weeks (±7 days) for 9 treatment cycles (108 weeks)...
February 5, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29404375/use-of-selective-serotonin-reuptake-inhibitor-and-midodrine-in-a-patient-with-autonomic-instability-2-2-compressive-squamous-cell-carcinoma-and-pain
#14
Kyle Ball, Thomas P Vacek
A rare cause of reflex syncope is metastatic cancers involving the head and neck. These can irritate the glossopharyngeal nerve and lead to glossopharyngeal neuralgia with associated syncope. This type of syncope is difficult to treat since it commonly involves both a vasodepressor and cardioinhibitory response, and typically requires removal of the irritative focus. We report a case of a 52-year-old male who presented from home with syncope. He endorsed a 5-week history of progressively worsened positional headaches and dramatic 40-pound weight loss with night sweats over 6 months...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29402395/intestinal-worms-eating-neuropsychiatric-disorders-apparently-so
#15
Henry H Kou, William Parker
A number of factors in Western society, including inflammatory diets, sedentary lifestyles, vitamin D deficiency and chronic psychological stress, are known to induce inflammation and to be associated with neuropsychiatric disorders. One factor that is emerging as a potential inflammation inducing factor is biota depletion, or loss of biodiversity from the ecosystem of the human body as a result of industrialization. Originally known as the "hygiene hypothesis", biota alteration theory describes the effects of biota alteration on the human immune system...
February 2, 2018: Brain Research
https://www.readbyqxmd.com/read/29400003/incidence-and-outcome-of-subarachnoid-haemorrhage-in-the-general-and-emergency-department-populations-in-queensland-from-2010-to-2014
#16
Kevin H Chu, Ibrahim Mahmoud, Xiang-Yu Hou, Craig D Winter, Rosalind L Jeffree, Nathan J Brown, Anthony Ft Brown
OBJECTIVES: To determine: (i) incidence and outcome of subarachnoid haemorrhage (SAH) in the general population; and (ii) proportions of SAH in both the general ED population and in ED patients presenting with headache. METHODS: A population-based study in Queensland from January 2010 to December 2014 was conducted. Data were sourced from the Australian Bureau of Statistics, Queensland Hospital Admitted Patient Data Collection linked to the Queensland death registry and ED Information System...
February 5, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29395690/benign-headache-management-in-the-emergency-department
#17
Brit J Long, Alex Koyfman
BACKGROUND: Headache is a common complaint managed in the emergency department (ED), with emergency physicians focusing on evaluation for life-threatening conditions while treating pain and nausea. OBJECTIVE: This review evaluates the treatment of benign, primary headaches in the ED, with recommendations provided based on the literature. DISCUSSION: Headaches are a major cause of disability in the United States and a common condition managed in the ED...
January 27, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29395284/safety-and-efficacy-of-intravenous-lidocaine-for-pain-management-in-the-emergency-department-a-systematic-review
#18
REVIEW
Lucas Oliveira J E Silva, Kristin Scherber, Daniel Cabrera, Sergey Motov, Patricia J Erwin, Colin P West, M Hassan Murad, M Fernanda Bellolio
STUDY OBJECTIVE: We evaluate the safety and efficacy of intravenous lidocaine in adult patients with acute and chronic pain who are undergoing pain management in the emergency department (ED). METHODS: We searched Ovid CENTRAL, Ovid EMBASE, and Ovid MEDLINE databases for randomized controlled trials and observational studies from inception to January 2017. Efficacy outcomes included reduction in pain scores from baseline to postintervention and need for rescue analgesia...
January 29, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29390459/successful-treatment-of-an-acute-infective-endocarditis-secondary-to-fish-bone-penetrating-into-left-atrium-caused-by-granulicatella-adiacens-and-candida-albicans-a-case-report
#19
Ya Ling Tong, Ting Ting Qu, Jia Xu, Nai Yun Chen, Mei Fang Yang
RATIONAL: Infective endocarditis caused by a foreign body of the upper digestive tract is rare. We report a rare case of Granulicatella adiacens and Candida albicans coinfection acute endocarditis combined with systematic embolization caused by a fish bone from the esophagus penetrating into the left atrium. PATIENT CONCERN: A 42-year-old woman was admitted to our hospital because of fever, abdominal pain, headache, and right limb weakness. DIAGNOSES: Clinical examination indicated endocarditis and systemic embolisms secondary to a fish bone from the esophagus penetrating into the left atrium...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390365/bilateral-acute-myopia-and-angle-closure-glaucoma-induced-by-ma-huang-ephedra-a-case-report
#20
So Jung Ryu, Yong Un Shin, Min Ho Kang, Hee Yoon Cho, Mincheol Seong
RATIONALE: Cases of bilateral acute angle closure have been reported after use of various drugs. PATIENT CONCERNS: A 52-year-old woman visited the emergency room and complained of acute bilateral ocular pain and decreased vision accompanied by headache, nausea, and vomiting. One day before, she had started a herbal medicine containing Ma-huang for weight loss. On examinations, myopic shift, edematous cornea, increased intraocular pressure, shallow anterior chamber, and thickened choroid on both eyes were observed...
December 2017: Medicine (Baltimore)
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