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Psychopharmacology Review

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https://www.readbyqxmd.com/read/29225554/recent-developments-in-psychopharmaceutical-approaches-to-treating-female-sexual-interest-and-arousal-disorder
#1
REVIEW
Stephanie Both
Purpose of Review: This review summarizes the recent literature and empirical studies on psychopharmacological approaches to treating female sexual interest/arousal disorder (FSIAD). Recent Findings: Several new drugs for FSIAD that are intended to increase sexual responsiveness by influencing central excitatory and inhibitory neuromodulatory processes are under development. Studies on flibanserin resulted in the first approved medication for the treatment of low sexual desire in premenopausal women...
2017: Current Sexual Health Reports
https://www.readbyqxmd.com/read/29215386/improving-the-clinical-pharmacologic-assessment-of-abuse-potential-part-1-regulatory-context-and-risk-management
#2
Edward M Sellers
PURPOSE: This article brings to the attention of drug developers the Food and Drug Administration's (FDA's) recent final Guidance to Industry on Assessment of Abuse Potential and provides practical suggestions about compliance with the Guidance. PROCEDURES: The Guidance areas are reviewed, analyzed, and placed in the context of current scientific knowledge and best practices to mitigate regulatory risk. FINDINGS: The Guidance provides substantial new detail on what needs to be done at all stages of drug development for central nervous system-active drugs...
December 6, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29209753/-neuroleptic-malignant-syndrome
#3
REVIEW
R Knorr, J Schöllkopf, E Haen
BACKGROUND: Neuroleptic malignant syndrome (NMS) is a rare but severe undesired complication of psychopharmacological treatment. The mortality has shown a significant decrease since its first description. Knowledge of NMS is important for every clinician because of the need for rapid diagnosis and treatment. OBJECTIVE: This article presents a review and critical appraisal of the current study situation for NMS. Recommendations for diagnostics, differential diagnostics and treatment are presented particularly from a clinical perspective...
December 5, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/29209235/the-endless-trip-among-the-nps-users-psychopathology-and-psychopharmacology-in-the-hallucinogen-persisting-perception-disorder-a-systematic-review
#4
REVIEW
Laura Orsolini, Gabriele Duccio Papanti, Domenico De Berardis, Amira Guirguis, John Martin Corkery, Fabrizio Schifano
Hallucinogen-persisting perception disorder (HPPD) is a syndrome characterized by prolonged or reoccurring perceptual symptoms, reminiscent of acute hallucinogen effects. HPPD was associated with a broader range of LSD (lysergic acid diethylamide)-like substances, cannabis, methylenedioxymethamphetamine (MDMA), psilocybin, mescaline, and psychostimulants. The recent emergence of novel psychoactive substances (NPS) posed a critical concern regarding the new onset of psychiatric symptoms/syndromes, including cases of HPPD...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29194557/caution-is-key-when-prescribing-for-older-adults
#5
Laura G Leahy
The end of the year can trigger the recognition that aging adults are no longer as independent as they once were. Psychiatric nurses and other mental health professionals may see an increase in older adults being referred for treatment. As the most appropriate psychosocial/psychotherapeutic and psychopharmacological treatments are identified for older adults, there are some unique challenges inherent in coordinating the care of this population. It is especially important for prescribing psychiatric advanced practice nurses to update, review, and cross-reference older patients' lists of medications at every appointment...
December 1, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29188907/prescribing-patterns-in-a-psychiatrically-referred-sample-of-youth-with-autism-spectrum-disorder
#6
Julia Shekunov, Janet Wozniak, Kristina Conroy, Elizabeth Pinsky, Maura Fitzgerald, Melissa F de Leon, Abigail Belser, Joseph Biederman, Gagan Joshi
OBJECTIVE: The aim of this study was to examine the pattern of psychopharmacologic interventions in a psychiatrically referred sample of youth with autism spectrum disorder (ASD). METHODS: This retrospective chart review aimed at collecting demographic and clinical information, including data on DSM-IV-TR criteria-based psychiatric disorders and related current medication treatment and response. Data were collected in December 2011. Clinicians identified the target disorder for each medication and any adverse events...
November 28, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29136247/behavioral-mental-health-an-emerging-field-of-service-or-an-oxymoron
#7
Christopher G Hudson
Proliferation in the use of the terminology around behavioral mental health suggests, on one hand, an emerging field of service that integrates psychiatric, substance abuse, and related services. On the other hand, this development also raises questions about the coherence of this approach. This review explores the history, definitional issues, current trends, and available data on the impact of this field. It considers a variety of critiques of behavioral mental health, such as possibility that the field attempts to integrate fundamentally incompatible domains, that the term "behavioral mental health" is thus an oxymoron, and that it represents a co-optation by the insurance industry of traditional ideals of mental health and of behavioral medicine or as code for the implementation of a medical model that emphasizes short-term, behavioral, and psychopharmacological treatments at the expense of a truly biopsychosocial orientation...
November 9, 2017: Social Work
https://www.readbyqxmd.com/read/29077621/a-systematic-review-of-atypical-antipsychotics-in-chronic-pain-management-olanzapine-demonstrates-potential-in-central-sensitization-fibromyalgia-and-headache-migraine
#8
Xavier F Jimenez, Tharani Sundararajan, Edward C Covington
INTRODUCTION: Many psychopharmacologic agents are used as primary or adjunct agents in pain management. Atypical antipsychotics (AAs) have also been used as adjuncts in pain management regimens in a variety of manners; however, their efficacy in this capacity is unclear. METHODS: A systematic review of all studies examining AA use for pain was conducted. Three literature databases were utilized to search for word combinations of "pain" and a variety of commonly-prescribed AAs (olanzapine, quetiapine, risperidone, aripiprazole, ziprasidone, clozapine, paliperidone, iloperidone, lurasidone)...
October 26, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29047301/pimavanserin-novel-pharmacotherapy-for-parkinson-s-disease-psychosis
#9
Zeyad T Sahli, Frank I Tarazi
Pimavanserin is the first FDA-approved atypical antipsychotic drug indicated for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Areas covered: This review focuses on the preclinical discovery of pimavanserin. It analyzes the pharmacological, behavioral and molecular mechanisms of pimavanserin and their contribution to the therapeutic advantages of the drug as reported in published preclinical and clinical studies, press releases and product labels. Expert opinion: Pimavanserin exhibits a unique pharmacological profile with nanomolar affinity at serotonin 5-HT2A and 5-HT2C receptors...
October 31, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29046149/schizophrenia-and-nicotine-dependence-what-psychopharmacological-treatment-options-are-available-for-the-duo-perturbationes
#10
Yoong Mei Theng, Suzaily Wahab, Noor Alaudin Wahab, Hatta Sidi, Srijit Das
Nicotine dependence has progressively become a foremost community health interest in the both developed and developing nations due to the economic burden and health-related problem. Smoking was significantly higher among patients with schizophrenia in comparison to the general population. Nicotine dependence is not only associated with public stress, but among patients with schizophrenia, smoking brings major challenges to the management. Nicotine may diminish the therapeutic efficacy of the bioavailability of the psychopharmacological agents in-vivo...
October 17, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29037340/-neuropsychiatry-of-movement-disorders
#11
Juan Manuel Orjuela-Rojas, Gustavo Adolfo Barrios Vincos, Melisa Alejandra Martínez Gallego
Movement disorders can be defined as neurological syndromes presenting with excessive or diminished automatic or voluntary movements not related to weakness or spasticity. Both Parkinson's disease (PD) and Huntington's disease (HD) are well-known examples of these syndromes. The high prevalence of comorbid psychiatric symptoms like depression, anxiety, obsessive-compulsive symptoms, hallucinations, delusions, impulsivity, sleep disorders, apathy and cognitive impairment mean that these conditions must be regarded as neuropsychiatric diseases...
October 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29028643/pharmacotherapy-of-borderline-personality-disorder-replacing-confusion-with-prudent-pragmatism
#12
Vladan Starcevic, Aleksandar Janca
PURPOSE OF REVIEW: The article aims to examine trends in the pharmacological treatment of borderline personality disorder (BPD) and shed more light on the attendant controversies. RECENT FINDINGS: Although specialized, BPD-centred psychotherapy is considered first-line treatment for BPD and no psychotropic drug has been licensed for BPD, medications are frequently prescribed in the management of this condition. Various classes of psychopharmacological agents are used for BPD and there is a prominent polypharmacy...
October 11, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29018367/treatment-of-comorbid-alcohol-dependence-and-anxiety-disorder-review-of-the-scientific-evidence-and-recommendations-for-treatment
#13
REVIEW
Carmen Gimeno, Marisa Luisa Dorado, Carlos Roncero, Nestor Szerman, Pablo Vega, Vicent Balanzá-Martínez, F Javier Alvarez
Patients with alcohol-use disorders (AUDs) have a high prevalence of anxiety disorders (AnxDs). "Co-occurring disorders" refers to the coexistence of an AUD and/or drug related disorders with another non-addictive psychiatric disorder. The aim of this study was to assess the effectiveness of psychopharmacological treatments and psychotherapy in patients with AUD and AnxD and to propose recommendations for the treatment of patients with comorbid AnxDs and AUDs. Randomized clinical trials, meta-analyses, and clinical guidelines were retrieved from PubMed, Embase, and Cochrane databases...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28945182/the-role-of-the-therapeutic-relationship-in-psychopharmacological-treatment-outcomes-a-meta-analytic-review
#14
Christine M Wienke Totura, Sherecce A Fields, Marc S Karver
OBJECTIVE: Patient nonadherence to psychopharmacological treatment is a significant barrier to effective treatment. The therapeutic relationship is known to be a critical component of effective psychological treatment, but it has received limited study. A meta-analysis was conducted to examine the role of the therapeutic relationship in the delivery of effective psychopharmacological treatment. METHODS: PubMed, PsycINFO, CINAHL, Google Scholar, Ingenta, and the Web of Science-Science Citation Index were searched, including reference lists of found articles...
September 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28914382/clinical-high-risk-for-psychosis-in-children-and-adolescents-a-systematic-review
#15
REVIEW
Jordina Tor, Montserrat Dolz, Anna Sintes, Daniel Muñoz, Marta Pardo, Elena de la Serna, Olga Puig, Gisela Sugranyes, Inmaculada Baeza
The concept of being at risk for psychosis has been introduced both for adults and children and adolescents, but fewer studies have been conducted in the latter population. The aim of this study is to systematically review the articles associated with clinical description, interventions, outcome and other areas in children and adolescents at risk for psychosis. We searched in MEDLINE/PubMed and PsycINFO databases for articles published up to 30/06/16. Reviewed articles were prospective studies; written in English; original articles with Clinical High Risk (CHR) for psychosis samples; and mean age of samples younger than 18 years...
September 15, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28910145/the-clinical-pharmacokinetics-of-amphetamines-utilized-in-the-treatment-of-attention-deficit-hyperactivity-disorder
#16
John S Markowitz, Kennerly S Patrick
Amphetamine (AMP), an indirectly acting psychostimulant approved for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children, adolescents, and adults, is among the most long-standing therapeutic agents in all of clinical psychopharmacology. This review focuses on AMP absorption, metabolism, and elimination brought to bear on comparative pharmacokinetics in its various formulations. A comprehensive search of the published literature was conducted using MEDLINE (PubMed) and Google Scholar databases through April 2017 to retrieve all pertinent in vitro and human studies for review and synthesis...
October 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28899507/ziziphus-spinosa-seeds-for-insomnia-a-review-of-chemistry-and-psychopharmacology
#17
REVIEW
Johannah Linda Shergis, Xiaojia Ni, Jerome Sarris, Anthony Lin Zhang, Xinfeng Guo, Charlie C Xue, Chuanjian Lu, Helmut Hugel
BACKGROUND: In Chinese medicine, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou is widely used for the treatment of insomnia. PURPOSE/SECTIONS: This paper summarises the chemistry, psychopharmacology, and compares the pharmaceutical effects of the seeds of Ziziphus jujuba plant, Ziziphus spinosa (ZS) seeds, with benzodiazepines. Whole extracts and constituent compounds have been evaluated in preclinical and clinical studies. CONCLUSIONS: ZS secondary metabolites modulate GABAergic activity and the serotonergic system...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28888918/effects-of-psychopharmacological-treatment-with-antipsychotic-drugs-on-the-vascular-system
#18
REVIEW
Kai G Kahl, Mechthild Westhoff-Bleck, Tillmann H C Krüger
Psychopharmacological treatment with antipsychotic drugs is an essential part of guideline-based treatment strategies in psychotic disorders, such as schizophrenia, schizoaffective disorders, and delusional disorders. Other mental disorders frequently treated with antipsychotic drugs are bipolar disorders, and major depressive disorder. Furthermore, antipsychotic drugs are often given in emergency and surgical units for the treatment of metabolic or postoperative delirium. Antipsychotic drugs can exert direct and indirect effects on the vascular system, potentially leading to severe complications such as thromboembolism...
September 6, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28887224/the-zebrafish-as-a-promising-tool-for-modeling-human-brain-disorders-a-review-based-upon-an-ibns-symposium
#19
REVIEW
Soaleha Shams, Jason Rihel, Jose G Ortiz, Robert Gerlai
The zebrafish represents an excellent compromise between system complexity and practical simplicity, features that make it useful for modeling and mechanistic analysis of complex brain disorders. Also promising are screens for psychoactive drugs with effects on larval and adult zebrafish behavior. This review, based upon a recent symposium held at the 2016 IBNS Congress, provides different perspectives on how the zebrafish may be utilized to advance research into human central nervous system disorders. It starts with a discussion on an important bottleneck in zebrafish research, measuring the behavior of this species (specifically shoaling), and continues with examples on research on autism spectrum disorder in larval zebrafish, on screening natural products for compounds with psychoactive properties in adult zebrafish, and on the development of a zebrafish model of fetal alcohol spectrum disorders...
September 5, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28867936/cultural-aspects-of-anxiety-disorders-in-india
#20
Maherra Khambaty, Rajesh M Parikh
Cultural factors have influenced the presentation, diagnoses, and treatment of anxiety disorders in India for several centuries. This review covers the antecedents, prevalence, phenomenology, and treatment modalities of anxiety disorders in the Indian cultural context. It covers the history of the depiction of anxiety in India and the concept of culture in the classification of anxiety disorders, and examines the cultural factors influencing anxiety disorders in India. We review the prevalence and phenomenology of various disorders, such as generalized anxiety disorder, panic disorder, social anxiety, and phobic disorder, as well as culture-specific syndromes such as dhat and koro in India...
June 2017: Dialogues in Clinical Neuroscience
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