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Psychopharmacology Review

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https://www.readbyqxmd.com/read/28792289/a-guide-to-psychopharmacological-treatment-of-patients-with-intellectual-disability-in-psychiatry
#1
Rosa M Molina-Ruiz, Julia Martín-Carballeda, Inmaculada Asensio-Moreno, Francisco Montañés-Rada
Background Subjects with intellectual disability are at increased risk of having comorbid psychiatric disorders and worse response to psychotherapeutic and psychopharmacological treatment interventions. On the other hand, available data on best treatment approach in this population are scarce and lack scientific evidence due to methodological limitations. The present study aims to perform a systematic review of the literature to facilitate the use of psychotropic drugs in clinical practice and better establish future research targets in this field...
March 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28783928/korean-medication-algorithm-for-depressive-disorder-comparisons-with-other-treatment-guidelines
#2
REVIEW
Hee Ryung Wang, Won-Myong Bahk, Jeong Seok Seo, Young Sup Woo, Young-Min Park, Jong-Hyun Jeong, Won Kim, Se-Hoon Shim, Jung Goo Lee, Duk-In Jon, Kyung Joon Min
In this review, we compared recommendations from the Korean Medication Algorithm Project for Depressive Disorder 2017 (KMAP-DD 2017) to other global treatment guidelines for depression. Six global treatment guidelines were reviewed; among the six, 4 were evidence-based guidelines, 1 was an expert consensus-based guideline, and 1 was an amalgamation of both evidence and expert consensus-based recommendations. The recommendations in the KMAP-DD 2017 were generally similar to those in other global treatment guidelines, although there were some differences between the guidelines...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28754273/effects-of-psychopharmacological-treatment-with-antidepressants-on-the-vascular-system
#3
REVIEW
Kai G Kahl, Mechthild Westhoff-Bleck, Tillmann H C Krüger
Psychopharmacological treatment with antidepressants is an essential part of guideline-based treatment strategies in affective disorders, such as major depressive disorder, persistent depressive disorder, and bipolar disorder. Furthermore, antidepressants are frequently prescribed in patients with physical disorders, such as cardiovascular diseases, and comorbid depression. The type of association between physical diseases, particularly chronic diseases, and depression is bidirectional, meaning that affective disorders enhance the risk for the development of cardiovascular and metabolic disorders, and that cardiovascular/metabolic disorders enhance the risk for the development of depressive disorders...
July 25, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28722481/clinical-management-of-pediatric-acute-onset-neuropsychiatric-syndrome-part-i-psychiatric-and-behavioral-interventions
#4
Margo Thienemann, Tanya Murphy, James Leckman, Richard Shaw, Kyle Williams, Cynthia Kapphahn, Jennifer Frankovich, Daniel Geller, Gail Bernstein, Kiki Chang, Josephine Elia, Susan Swedo
OBJECTIVE: This article outlines the consensus guidelines for symptomatic treatment for children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Syndrome Associated with Streptococcal Infection (PANDAS). METHODS: Extant literature on behavioral, psychotherapeutic, and psychopharmacologic treatments for PANS and PANDAS was reviewed. Members of the PANS Research Consortium pooled their clinical experiences to find agreement on treatment of PANS and PANDAS symptoms...
July 19, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28721049/the-potential-role-of-vagus-nerve-stimulation-in-the-treatment-of-hiv-associated-depression-a-review-of-literature
#5
REVIEW
William C Nicholson, Mirjam-Colette Kempf, Linda Moneyham, David E Vance
Depression is the most common comorbidity and neuropsychiatric complication in HIV. Estimates suggest that the prevalence rate for depression among HIV-infected individuals is three times that of the general population. The association between HIV and clinical depression is complex; however, chronic activation of inflammatory mechanisms, which disrupt central nervous system (CNS) function, may contribute to this association. Disruptions in CNS function can result in cognitive disorders, social withdrawal, fatigue, apathy, psychomotor impairment, and sleep disturbances, which are common manifestations in depression and HIV alike...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28682531/florida-best-practice-psychotherapeutic-medication-guidelines-for-adults-with-major-depressive-disorder
#6
REVIEW
Roger S McIntyre, Trisha Suppes, Rajiv Tandon, Michael Ostacher
OBJECTIVE: Herein we provide the 2015 update for the Florida Best Practice Psychotherapeutic Medication Guidelines (FPG) for major depressive disorder (MDD). The FPG represent evidence-based decision support for practitioners providing care to adults with MDD. PARTICIPANTS: The consensus meeting included representatives from the Florida Agency for Health Care Administration (FAHCA), advocacy members, academic experts in MDD, and multidisciplinary mental health clinicians, as well as health policy experts...
June 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28681620/the-burden-of-mood-disorder-cerebrovascular-disease-comorbidity-essential-neurobiology-psychopharmacology-and-physical-activity-interventions
#7
Michele Fornaro, Marco Solmi, Nicola Veronese, Domenico De Berardis, Elisabetta Filomena Buonaguro, Carmine Tomasetti, Giampaolo Perna, Antonio Preti, Mauro Giovanni Carta
Cardio-vascular diseases (CVDs) and CVD-related disorders (including cerebrovascular diseases; CBVDs) are a major public health concern as they represent the leading cause of mortality and morbidity in developed countries. Patients with CVDs and CBVDs co-morbid with mood disorders, especially bipolar disorder (BD) and major depressive disorder (MDD), suffer reduced quality-of-life and significant disability adjusted for years of life and mortality. The relationship between CVDs/CBVDs and mood disorders is likely to be bidirectional...
July 6, 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/28680405/cannabinoids-and-vanilloids-in-schizophrenia-neurophysiological-evidence-and-directions-for-basic-research
#8
REVIEW
Rafael N Ruggiero, Matheus T Rossignoli, Jana B De Ross, Jaime E C Hallak, Joao P Leite, Lezio S Bueno-Junior
Much of our knowledge of the endocannabinoid system in schizophrenia comes from behavioral measures in rodents, like prepulse inhibition of the acoustic startle and open-field locomotion, which are commonly used along with neurochemical approaches or drug challenge designs. Such methods continue to map fundamental mechanisms of sensorimotor gating, hyperlocomotion, social interaction, and underlying monoaminergic, glutamatergic, and GABAergic disturbances. These strategies will require, however, a greater use of neurophysiological tools to better inform clinical research...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28676437/deep-brain-stimulation-and-treatment-resistant-obsessive-compulsive-disorder-a-systematic-review
#9
Javier Vázquez-Bourgon, Juan Martino, María Sierra Peña, Jon Infante Ceberio, M Ángeles Martínez Martínez, Roberto Ocón, José Manuel Menchón, Benedicto Crespo Facorro, Alfonso Vázquez-Barquero
INTRODUCTION: At least 10% of patients with Obsessive-compulsive Disorder (OCD) are refractory to psychopharmacological treatment. The emergence of new technologies for the modulation of altered neuronal activity in Neurosurgery, deep brain stimulation (DBS), has enabled its use in severe and refractory OCD cases. The objective of this article is to review the current scientific evidence on the effectiveness and applicability of this technique to refractory OCD. METHOD: We systematically reviewed the literature to identify the main characteristics of deep brain stimulation, its use and applicability as treatment for obsessive-compulsive disorder...
July 1, 2017: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/28676017/antipsychotic-drugs-from-receptor-binding-profiles-to-metabolic-side-effects
#10
Spyridon Siafis, Dimitrios Tzachanis, Myrto Samara, Georgios Papazisis
Antipsychotic-induced metabolic side effects are major concerns in psychopharmacology and clinical psychiatry. Their pathogenetic mechanisms are still not elucidated. Antipsychotic drugs seem to interfere with feeding behaviors and energy balance processes that control metabolic regulation. Reward and energy balance centers in central nervous system constitute the central level of metabolic regulation. The peripheral level consists of skeletal muscles, the liver, the pancreas, the adipose tissue and neuroendocrine connections...
June 30, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28657180/4-4-dimethylaminorex-4-4-dmar-serotoni-misuse-a-web-based-study
#11
Barbara Loi, Mire Zloh, Maria Antonietta De Luca, Nicholas Pintori, John Corkery, Fabrizio Schifano
BACKGROUND: 4,4'-DMAR (4,4'-dimethylaminorex; "Serotoni") is a potent stimulant drug that has recently been associated with a number of fatalities in Europe. Over the last few years, online communities have emerged as important resources for disseminating levels of technical knowledge on novel psychoactive substances. OBJECTIVE: Analysing the information provided by the fora communities on 4,4'-DMAR use, additionally critical reviewing the available evidence-based literature on this topic...
May 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28654193/serotonin-transporter-gene-polymorphisms-and-ssri-tolerability-review-of-pharmacogenetic-evidence
#12
Jing Zhu, Michele Klein-Fedyshin, James M Stevenson
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacotherapy for mood and anxiety disorders. The common mechanism of drugs in this class is antagonism of the serotonin transporter. Within the serotonin transporter gene SLC6A4, two polymorphic sites termed 5-HTTLPR and STin2 are proposed to have functional consequences and thus have been attractive candidates for pharmacogenetic studies of SSRI efficacy and tolerability studies. OBJECTIVE: This review summarizes approximately 15 years of study of these polymorphisms as they relate to SSRI tolerability phenotypes...
June 27, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28629285/acute-movement-disorders-in-the-medical-setting
#13
Ifrah Zawar, Mario A Caro, Lara Feldman, Xavier F Jimenez
Objective Psychosomatic medicine psychiatrists are often tasked with the evaluation and treatment of complex neuropsychiatric states which may be motoric in phenotype. Little energy has been dedicated to understanding acute movement disorders in the hospital environment. Method Recognizing the importance of frontal-subcortical (corticostriatothalamocortical) circuitry and basal ganglia structures, we present a case series of acute movement disorder phenotypes resulting from underlying medical conditions, commonly-administered medications, or the interaction of both...
July 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28621715/neuropsychiatric-burden-in-huntington-s-disease
#14
REVIEW
Ricardo Augusto Paoli, Andrea Botturi, Andrea Ciammola, Vincenzo Silani, Cecilia Prunas, Claudio Lucchiari, Elisa Zugno, Elisabetta Caletti
Huntington's disease is a disorder that results in motor, cognitive, and psychiatric problems. The symptoms often take different forms and the presence of disturbances of the psychic sphere reduces patients' autonomy and quality of life, also impacting patients' social life. It is estimated that a prevalence between 33% and 76% of the main psychiatric syndromes may arise in different phases of the disease, often in atypical form, even 20 years before the onset of chorea and dementia. We present a narrative review of the literature describing the main psychopathological patterns that may be found in Huntington's disease, searching for a related article in the main database sources (Medline, ISI Web of Knowledge, Scopus, and Medscape)...
June 16, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28610629/the-use-of-imepitoin-pexion%C3%A2-on-fear-and-anxiety-related-problems-in-dogs-a-case-series
#15
Kevin J McPeake, Daniel S Mills
BACKGROUND: Fear and anxiety based problems are common in dogs. Alongside behaviour modification programmes, a range of psychopharmacological agents may be recommended to treat such problems, but few are licensed for use in dogs and the onset of action of some can be delayed. The low affinity partial benzodiazepine receptor agonist imepitoin (Pexion™, Boehringer Ingelheim) is licensed for treating canine epilepsy, has a fast onset of action in dogs and has demonstrated anxiolytic properties in rodent models...
June 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28582989/a-situation-analysis-of-psychiatrists-in-south-africa-s-rural-primary-healthcare-settings
#16
Johannes H De Kock, Basil J Pillay
BACKGROUND: South Africa (SA) has been facing serious challenges in providing human resources for the delivery of essential mental health (MH) services. The majority of its prescribing MH specialists, psychiatrists, practise in private, urban and peri-urban areas. The findings of a situation analysis audit of psychiatrist human resources in the public rural primary healthcare (PRPHC) sector are presented in this paper. METHOD: This audit was based on both primary and secondary data...
May 29, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/28577352/increased-postpartum-haemorrhage-the-possible-relation-with-serotonergic-and-other-psychopharmacological-drugs-a-matched-cohort-study
#17
Hanna M Heller, Anita C J Ravelli, Andrea H L Bruning, Christianne J M de Groot, Fedde Scheele, Maria G van Pampus, Adriaan Honig
BACKGROUND: Postpartum haemorrhage is a major obstetric risk worldwide. Therefore risk factors need to be investigated to control for this serious complication. A recent systematic review and meta-analysis revealed that the use of both serotonergic and non-serotonergic antidepressants in pregnancy are associated with a higher risk of postpartum haemorrhage. However, use of antidepressants in pregnancy is often necessary because untreated depression in pregnancy is associated with adverse maternal and neonatal outcome, such as postpartum depression, preterm birth and dysmaturity...
June 2, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28559634/a-review-of-psychopharmacological-interventions-post-disaster-to-prevent-psychiatric-sequelae
#18
REVIEW
Badari Birur, Suresh Bada Math, Rachel E Fargason
BACKGROUND: Disasters are mega-scale catastrophic events which cause trauma and mental health sequelae. A review of early pharmacological interventions for the prevention of psychiatric disorders following disasters is sorely needed. METHODS: A literature search of "Psychiatric Sequelae AND Disasters", "Disaster mental health/Disaster psychiatry", "Psychotropics AND Disasters", and "Drug therapy AND Disasters" yielded 213 articles, 38 of which were included in the review...
January 26, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28545371/a-psycho-behavioral-perspective-on-modelling-obsessive-compulsive-disorder-ocd-in-animals-the-role-of-context
#19
De Wet Wolmarans, Dan J Stein, Brian H Harvey
Obsessive-compulsive disorder is a heterogeneous and debilitating condition, characterized by intrusive thoughts and compulsive repetition. Animal models of OCD are important tools that have the potential to contribute significantly to our understanding of the condition. Although there is consensus that pre-clinical models are valuable in elucidating the underlying neurobiology in psychiatric disorders, the current paper attempts to prompt ideas on how interpretation of animal behavior can be expanded upon to more effectively converge with the human disorder...
May 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28529139/psychopharmacology-of-combined-activation-of-the-serotonin1a-and-%C3%AF-1-receptors
#20
REVIEW
Yukio Ago, Shigeru Hasebe, Naoki Hiramatsu, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsuda
The selective serotonin (5-HT) reuptake inhibitors (SSRIs) are generally used for the treatment of major depressive disorders, and the 5-HT1A and σ1 receptors are considered to be targets for treatment of psychiatric disorders. Some SSRIs such as fluvoxamine have agonistic activity towards for the σ1 receptor, but it is not known whether the effect on the receptor plays a key role in the pharmacological effects. We have recently demonstrated that fluvoxamine shows an anti-anhedonic effect in picrotoxin-induced model of anxiety/depression, while the SSRI paroxetine, which have little affinity for the σ1 receptor, does not...
May 18, 2017: European Journal of Pharmacology
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