keyword
https://read.qxmd.com/read/38477254/serotonergic-regulation-of-cortical-neurovascular-coupling-and-hemodynamics-upon-awakening-from-sleep-in-mice
#1
JOURNAL ARTICLE
Akiyo Natsubori, Soojin Kwon, Yoshiko Honda, Takashi Kojima, Akihiro Karashima, Kazuto Masamoto, Makoto Honda
Neurovascular coupling (NVC) is the functional hyperemia of the brain responding to local neuronal activity. It is mediated by astrocytes and affected by subcortical ascending pathways in the cortex that convey information, such as sensory stimuli and the animal condition. Here, we investigate the influence of the raphe serotonergic system, a subcortical ascending arousal system in animals, on the modulation of cortical NVC and cerebral blood flow (CBF). Raphe serotonergic neurons were optogenically activated for 30 s, which immediately awakened the mice from non-rapid eye movement sleep...
March 13, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38471125/polytrauma-in-children%C3%A2-epidemiology-acute-diagnostic-evaluation-and-treatment
#2
REVIEW
Monica Christine Ciorba, Marc Maegele
BACKGROUND: Inadequate clinical experience still causes uncertainty in the acute diagnostic evaluation and treatment of polytrauma in children (with or without coagulopathy). This review deals with the main aspects of the acute care of severely injured children in the light of current guidelines and other relevant literature, in particular airway control, volume and coagulation management, acute diagnostic imaging, and blood coagulation studies in the shock room. METHODS: This review is based on literature retrieved by a selective search in PubMed, Medline (OVIDSP), the Cochrane Central Register of Controlled Trials, and Epistemonikos covering the period January 2001 to August 2023...
May 17, 2024: Deutsches Ärzteblatt International
https://read.qxmd.com/read/38465530/endovascular-repair-of-ruptured-aortic-aneurysm-a-single-center-experience
#3
JOURNAL ARTICLE
Uygar Çağdaş Yüksel, Serkan Asil, Erkan Yıldırım, Mehmet Sadık Karpat, Suat Görmel, Serdar Fırtına, Salim Yaşar, Barış Buğan, Ayşe Saatçi Yaşar, Murat Çelik, Cengiz Bolcal, Cem Barçın
OBJECTIVE: Aortic rupture is a rare and catastrophic emergency. Prompt diagnosis and treatment are the primary determinants of mortality. During follow-up, the majority of patients who have been effectively treated die from hypovolemic shock and multiorgan failure. This article describes the clinical and procedural details of sixteen patients with ruptured aortic aneurysms treated endovascularly. In addition, it discusses the main factors contributing to the mortality of these patients...
March 2024: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://read.qxmd.com/read/38425662/successful-reimplantation-of-extruded-bone-segment-in-lower-limb-open-fractures-case-report-and-literature-review
#4
JOURNAL ARTICLE
Xiongke Hu, Qian Tan, Guanghui Zhu, Kun Liu
OBJECTIVE: The aim of this study is to summarize and demonstrate the different sterilization methods and surgical techniques for open fractures with impacted bone segments in the lower limbs. METHODS: A retrospective analysis was conducted on the clinical characteristics, treatment methods, and outcomes of a case involving a 10.5 cm extruded segment of the femur in a 9-year-old male with a right femoral comminuted fracture treated at our center. Additionally, a retrospective review and summary were conducted on all reported cases of open fractures with impacted bone segments in the lower limbs...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38425616/a-successful-endovascular-treatment-of-massive-hematuria-caused-by-aorto-ureteric-fistula-a-report-of-a-rare-case
#5
Konstantinos G Seretis, Theofanis Papas, Vasileios Papaioannou, Nikolaos Giannakopoulos, Andreas M Lazaris
Fistula formation between the urinary tract and the arterial system is very rare, and usually involves the ureter and the adjacent iliac vessels. Communication of the ureter with the aorta has been described a few times worldwide, and most of them had a fatal outcome. In our case, a 79-year-old man had a history of total cystectomy for malignancy and diversion of both ureters to a single site in the right hypogastrium with the left one crossing over the aorta. He was admitted elsewhere several times for intermittent hematuria, and four months ago the diagnosis of communication of the left ureter with a mycotic aortic pseudoaneurysm was made...
January 2024: Curēus
https://read.qxmd.com/read/38417803/pathophysiology-of-trauma-induced-coagulopathy
#6
JOURNAL ARTICLE
Herbert Schöchl, Felix C F Schmitt, Marc Maegele
Trauma-induced coagulopathy (TIC) is a complex hemostatic disturbance that can develop early after a major injury. There is no universally accepted definition of TIC. However, TIC primarily refers to the inability to achieve sufficient hemostasis in severely injured trauma patients, resulting in diffuse microvascular and life-threatening bleeding. Endogenous TIC is driven by the combination of hypovolemic shock and substantial tissue injury, resulting in endothelial damage, glycocalyx shedding, upregulated fibrinolysis, fibrinogen depletion, altered thrombin generation, and platelet dysfunction...
February 2024: Hämostaseologie
https://read.qxmd.com/read/38399520/coronary-artery-occlusion-with-sharp-blood-pressure-drop-during-general-anesthesia-induction-a-case-report
#7
Jae Young Ji, Yong Han Seo, Ho Soon Jung, Hea Rim Chun, Jin Soo Park, Woo Jong Kim, Jae Min Ahn, Yu Jun Park, Ye Eun Shin, Chan Ho Park
Most anesthetics reduce cardiac functions and lower blood pressure (BP), potentially causing excessive BP reduction in dehydrated patients or those with heart conditions, such as coronary artery disease (CAD). Considering the increased prevalence of cardiovascular disease with age, anesthesiologists must be cautious about BP reduction during general anesthesia in older adults. In the present case, a 76-year-old male patient with undiagnosed CAD in a hypovolemic state experienced a significant drop in systolic BP to the fifties during propofol and sevoflurane anesthesia...
January 29, 2024: Medicina
https://read.qxmd.com/read/38391980/a-comparison-of-normalization-techniques-for-individual-baseline-free-estimation-of-absolute-hypovolemic-status-using-a-porcine-model
#8
JOURNAL ARTICLE
Tamara P Lambert, Michael Chan, Jesus Antonio Sanchez-Perez, Mohammad Nikbakht, David J Lin, Afra Nawar, Syed Khairul Bashar, Jacob P Kimball, Jonathan S Zia, Asim H Gazi, Gabriela I Cestero, Daniella Corporan, Muralidhar Padala, Jin-Oh Hahn, Omer T Inan
Hypovolemic shock is one of the leading causes of death in the military. The current methods of assessing hypovolemia in field settings rely on a clinician assessment of vital signs, which is an unreliable assessment of hypovolemia severity. These methods often detect hypovolemia when interventional methods are ineffective. Therefore, there is a need to develop real-time sensing methods for the early detection of hypovolemia. Previously, our group developed a random-forest model that successfully estimated absolute blood-volume status (ABVS) from noninvasive wearable sensor data for a porcine model ( n = 6)...
January 23, 2024: Biosensors
https://read.qxmd.com/read/38384610/extra-pontine-myelinolysis-after-rapid-correction-of-hyponatremia-responding-to-levodopa
#9
Jagannath Dhadwad, Anish Chitnis
Osmotic demyelinating disease of the central nervous system has two variants: central pontine myelinolysis and extra-pontine myelinolysis (EPM). Up to 10% of cases of osmotic demyelination syndrome are associated with EPM, which mostly affects the thalamus and basal ganglia. It is commonly associated with the rapid correction of hyponatremia. An elderly woman in her 60s presented with complaints of acute gastroenteritis and giddiness and visited the emergency ward. On examination, she was conscious and oriented to time but disoriented to place and person and had slurring of speech with signs of dehydration...
January 2024: Curēus
https://read.qxmd.com/read/38371644/epidemiological-clinical-and-prognosis-aspects-of-acute-generalized-peritonitis-in-south-kivu-province-descriptive-observational-study-of-278-cases
#10
MULTICENTER STUDY
Jean Paul Buhendwa Cikwanine, Désiré Munyali Alumeti, Kivukuto John Mutendela, Prisca Kavira Ise-Somo, Jonathan Tunangoya Yoyu, Patrick Musimwa Ciza, Maroyi Raha, Willy Arung Kalau
INTRODUCTION: the aim was to determine epidemiological, clinical, therapeutic, and prognostic aspects of acute generalized peritonitis (AGP). METHODS: we conducted an observational, cross-sectional and multicentre study over 2 years of 278 cases of acute generalized peritonitis operated in semi-urban and urban hospitals in South-Kivu Province, Democratic Republic of Congo. RESULTS: the population of this study was young with a mean age was 28...
2024: Pan African Medical Journal
https://read.qxmd.com/read/38371512/refractory-human-cytomegalovirus-infection-without-evidence-of-genetic-resistance-in-the-ul-54-and-ul-97-genes-in-a-pediatric-hematopoietic-stem-cell-transplant-recipient-a-case-report
#11
Alejandra Pando-Caciano, Ketty Adid Escudero-Ramirez, Jackeline Carol Torres-Rodríguez, Holger Maita-Malpartida
Cytomegalovirus (CMV) infection is a common complication in patients undergoing hematopoietic stem cell transplantation (HSCT). Management of refractory CMV infections, especially in developing countries, can be challenging due to the limited availability of second and third-line antiviral drugs or alternative treatments. Here, we present a case of an 8 years-old patient diagnosed with acute myeloid leukemia. Eight months post-diagnosis, the patient underwent TCR-αβ+ /CD19+ -depleted haploidentical HSCT...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38335725/the-edwards-acumen-iq-system-using-peripheral-arterial-catheter-based-waveforms-to-estimate-cardiac-output-is-not-accurate-as-compared-to-thermodilution-in-dogs
#12
JOURNAL ARTICLE
Kristin M Zersen, Gregg M Griffenhagen, Eric L Monnet
OBJECTIVE: To assess the agreement between cardiac output (CO) estimated via evaluation of the arterial pressure waveform by a novel monitoring system (Edwards Acumen IQ sensor and HemoSphere Advanced Monitor Platform [HS-IQ]; Edwards LifeSciences) and measured by thermodilution (TD) in anesthetized, normovolemic, and hypovolemic dogs. To assess the agreement between the HS-IQ CO measurements in the radial artery and dorsal metatarsal artery. ANIMALS: 8 purpose-bred Beagles...
February 13, 2024: American Journal of Veterinary Research
https://read.qxmd.com/read/38328599/radiofrequency-venous-ablation-for-symptomatic-relief-in-postural-orthostatic-tachycardia-syndrome-a-case-series
#13
Catherine L B McGeoch, Rebecca S Steinberg, Kristina S Bortfeld, Zakaria Almuwaqqat, J Mark Rheudasil, Neal K Bhatia, Alexis C Cutchins
BACKGROUND: Hypovolemic postural orthostatic tachycardia syndrome (POTS) is thought to be caused by dysregulated circulating blood volume. Management is mainly limited to symptom-targeted lifestyle changes. Radiofrequency venous ablation (RFA) represents a minimally invasive method of increasing circulating blood volume. The following case series describes a novel application of RFA to successfully target POTS symptoms in patients demonstrating venous insufficiency. The use of RFA in alleviating POTS symptoms has not previously been reported...
February 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38318984/catalyst-free-anti-markovnikov-hydroamination-and-hydrothiolation-of-vinyl-heteroarenes-in-aqueous-medium-an-improved-process-towards-centhaquine
#14
JOURNAL ARTICLE
Anamika Yadav, Mayur D Ambule, Ajay Kumar Srivastava
Catalyst-free hydroamination and hydrothiolation of alkenes have been achieved in an aqueous medium. The anti-Markovnikov addition works efficiently in suspended water at room temperature and allows straightforward access to centhaquine, a drug used for the management of hypovolemic shocks in critically ill patients, and its derivatives. Various primary and secondary amines, thiols, and hydrazides were successfully reacted with a number of heteroaryl/aryl-alkenes. The scalability of the process has been demonstrated by synthesizing centhaquine at a 19...
February 6, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38304097/multiple-cystic-echinococcosis-in-abdominal-and-pelvic-cavity-treated-by-surgery-with-a-4-year-follow-up-a-case-report
#15
Lerong Yan, Zhiqiang Chu, Jian Yang, Yongguo Zhang, Guisheng Liu, Zhen Lei, Qian Chen, Jiang Li, Jing Yang, Meifeng Zhao, Shijie Zhang, Xiangwei Wu, Xinyu Peng, Hongwei Zhang
We report a case of a male patient who presented with multiple abdominal and pelvic echinococcosis. The patient had been diagnosed with hepatic echinococcosis for 7 years and developed intermittent distension and discomfort in the upper abdomen after an accidental fall. In recent years, the patient's abdominal distention increased gradually. Computed tomography revealed multiple hydatid cysts in the liver, spleen, abdominal cavity, and pelvic cavity. Abdominal organs were severely compressed, such that he could not eat normally except for a liquid diet...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38288724/isolated-hypoaldosteronism-is-a-cause-of-hypovolemic-but-not-euvolemic-hyponatremia
#16
JOURNAL ARTICLE
Jorge Gabriel Ruiz Sanchez, Alfonso Luis Calle-Pascual, Miguel Angel Rubio-Herrera, Maria Paz De Miguel Novoa, Emilia Gomez-Hoyos, Isabelle Runkle
INTRODUCTION: Hypoaldosteronism is characterized by hyperkalemia, and/or hypovolemic hyponatremia (HH), often accompanied by metabolic acidosis. HH is typical of hypoaldosteronism, whereas euvolemic hyponatremia (EH) is not. The purpose of the current study is to describe the characteristics of hyponatremia in hypoaldosteronism, and elucidate whether EH can be considered part the disease's spectrum. METHODS: In a hypoaldosteronism cohort, we analyzed the factors associated with hyponatremia, comparing the characteristics of EH and HH and their associated factors...
January 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38275927/evaluation-of-blood-lactate-heart-rate-blood-pressure-and-shock-index-and-their-association-with-prognosis-in-calves
#17
JOURNAL ARTICLE
Hélène Casalta, Calixte Bayrou, Salem Djebala, Justine Eppe, Linde Gille, Kris Gommeren, Eva Marduel, Arnaud Sartelet, Celine Seys, Jérôme Versyp, Sigrid Grulke
Diseases in young calves received as emergencies are often associated with hypovolemic and/or septic shocks. The objectives of our study were to (1) assess the correlation between clinical hemodynamic parameters and blood L-lactates (LAC), systolic blood pressure (SBP), and the shock index (SI) recorded upon arrival; and (2) to evaluate how these parameters were related to short-term outcomes in calves under 4 months of age presented as emergencies. We conducted a single-observer prospective observational study on calves aged from 1 day to 4 months, presented to the Veterinary Clinic for Ruminants of Liège from December 2020 to May 2022...
January 20, 2024: Veterinary Sciences
https://read.qxmd.com/read/38256339/spontaneous-retroperitoneal-bleeding-in-a-patient-with-systemic-lupus-erythematosus
#18
Wei-Hung Chen, Deng-Ho Yang
Background and Objectives : Systemic lupus erythematosus (SLE) is a disease with multiple organ involvement, and spontaneous hemorrhage, especially perirenal hemorrhage, is rare. Case Presentation : We report the case of a 19-year-old teenager with SLE who experienced left flank pain and hypovolemic shock. Abdominal computed tomography revealed a large left retroperitoneal hematoma. Recurrent hypovolemic shock occurred despite the transcatheter arterial embolization of the left renal artery. Repetitive abdominal computed tomography results showed active hemorrhage...
December 30, 2023: Medicina
https://read.qxmd.com/read/38232466/effects-and-mechanisms-of-perioperative-medications-on-the-hypothalamic-pituitary-adrenal-response-to-surgical-injury-a-narrative-review
#19
REVIEW
Yan Feng, Pan Chang, Jin Liu, Wen-Sheng Zhang
The adrenal gland is a vital endocrine organ, and adrenal steroid synthesis and secretion are closely regulated by the hypothalamic-pituitary-adrenal (HPA) axis in response to various stimuli. Surgery or trauma can activate the HPA axis and induce the secretion of cortisol. Different cortisol responses vary with the grade of surgery. Perioperative medications have the potential to decrease the cortisol level in the body, and both excessive and insufficient cortisol levels after surgery are disadvantageous. The effect of perioperative medications on the HPA response to surgery can be divided into three levels: "adrenal insufficiency (AI)", "stress response inhibition", and "uncertainty"...
January 16, 2024: Journal of Clinical Anesthesia
https://read.qxmd.com/read/38227983/a-rare-case-of-bleeding-jejunal-ulcer-diagnosed-by-intraoperative-use-of-enteroscopy
#20
Filagot Mikru, Ayenew Gucho, Jiksa Muleta, Ermias Tilahun, Kalkidan Haile, Eden Belayneh
INTRODUCTION: Small bowel bleeding can be overt or occult. Despite advances in imaging and endoscopy, the diagnosis and treatment of small bowel bleeding remain challenging due to its length and location. Diagnostic procedures such as push enteroscopy, capsule endoscopy and intraoperative enteroscopy are recommended to identify the source of bleeding. CASE PRESENTATION: A 33-year-old female with no prior history of bleeding diathesis presented with massive lower GI bleeding...
February 2024: International Journal of Surgery Case Reports
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