keyword
MENU ▼
Read by QxMD icon Read
search

Stat3

keyword
https://www.readbyqxmd.com/read/29908007/cocl-2-a-mimic-of-hypoxia-enhances-bone-marrow-mesenchymal-stem-cells-migration-and-osteogenic-differentiation-via-stat3-signaling-pathway
#1
Xin Yu, Qilong Wan, Gu Cheng, Xin Cheng, Jing Zhang, Janak L Pathak, Zubing Li
Mesenchymal stem cells homing and migration is a crucial step during bone fracture healing. Hypoxic environment in fracture site induces bone marrow mesenchymal stem cells (BMSCs) migration, but its mechanism remains unclear. Our previous study and studies by other groups have reported the involvement of signal transducer and activator of transcription 3 (STAT3) pathway in cell migration. However, the role of STAT3 pathway in hypoxia-induced cell migration is still unknown. In this study, we investigated the role of STAT3 signaling in hypoxia-induced BMSCs migration and osteogenic differentiation...
June 16, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29907694/hmgb1-induced-autophagy-facilitates-hepatic-stellate-cells-activation-a-new-pathway-in-liver-fibrosis
#2
Jing Li, Chuxiong Zeng, Beishi Zheng, Chun Liu, Min Tang, Yan Jiang, Yizhong Chang, Weiping Song, Yingxin Wang, Changqing Yang
High-mobility group box-1 (HMGB1) plays a context-dependent role in autophagy, which is required for hepatic stellate cells (HSCs) activation. However, the significance of HMGB1-induced HSCs autophagy in liver fibrosis has not been elucidated. Here, we first documented an enrichment of peripheral and intra-hepatic HMGB1 signal in hepatitis B virus (HBV)-related liver fibrosis progression, and presented the direct evidence of anatomic proximity of HMGB1 with a-SMA (a marker for HSCs activation) in cirrhotic liver specimens...
June 15, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29907692/who-regulates-whom-znf341-is-an-additional-player-in-the-stat3-t-h-17-song
#3
REVIEW
Avery August
Deficiency of ZNF341, a transcription factor featuring 12 Cys2His2 zinc fingers that regulates the expression and autoinduction of STAT3 (signal transducer and activator of transcription 3), results in hyper-immunoglobulin E syndrome and defective T helper 17 cell differentiation in humans.
June 15, 2018: Science Immunology
https://www.readbyqxmd.com/read/29907691/a-recessive-form-of-hyper-ige-syndrome-by-disruption-of-znf341-dependent-stat3-transcription-and-activity
#4
Vivien Béziat, Juan Li, Jian-Xin Lin, Cindy S Ma, Peng Li, Aziz Bousfiha, Isabelle Pellier, Samaneh Zoghi, Safa Baris, Sevgi Keles, Paul Gray, Ning Du, Yi Wang, Yoann Zerbib, Romain Lévy, Thibaut Leclercq, Frédégonde About, Ai Ing Lim, Geetha Rao, Kathryn Payne, Simon J Pelham, Danielle T Avery, Elissa K Deenick, Bethany Pillay, Janet Chou, Romain Guery, Aziz Belkadi, Antoine Guérin, Mélanie Migaud, Vimel Rattina, Fatima Ailal, Ibtihal Benhsaien, Matthieu Bouaziz, Tanwir Habib, Damien Chaussabel, Nico Marr, Jamel El-Benna, Bodo Grimbacher, Orli Wargon, Jacinta Bustamante, Bertrand Boisson, Ingrid Müller-Fleckenstein, Bernhard Fleckenstein, Marie-Olivia Chandesris, Matthias Titeux, Sylvie Fraitag, Marie-Alexandra Alyanakian, Marianne Leruez-Ville, Capucine Picard, Isabelle Meyts, James P Di Santo, Alain Hovnanian, Ayper Somer, Ahmet Ozen, Nima Rezaei, Talal A Chatila, Laurent Abel, Warren J Leonard, Stuart G Tangye, Anne Puel, Jean-Laurent Casanova
Heterozygosity for human signal transducer and activator of transcription 3 ( STAT3 ) dominant-negative (DN) mutations underlies an autosomal dominant form of hyper-immunoglobulin E syndrome (HIES). We describe patients with an autosomal recessive form of HIES due to loss-of-function mutations of a previously uncharacterized gene, ZNF341 ZNF341 is a transcription factor that resides in the nucleus, where it binds a specific DNA motif present in various genes, including the STAT3 promoter. The patients' cells have low basal levels of STAT3 mRNA and protein...
June 15, 2018: Science Immunology
https://www.readbyqxmd.com/read/29907690/znf341-controls-stat3-expression-and-thereby-immunocompetence
#5
Stefanie Frey-Jakobs, Julia M Hartberger, Manfred Fliegauf, Claudia Bossen, Magdalena L Wehmeyer, Johanna C Neubauer, Alla Bulashevska, Michele Proietti, Philipp Fröbel, Christina Nöltner, Linlin Yang, Jessica Rojas-Restrepo, Niko Langer, Sandra Winzer, Karin R Engelhardt, Cristina Glocker, Dietmar Pfeifer, Adi Klein, Alejandro A Schäffer, Irina Lagovsky, Idit Lachover-Roth, Vivien Béziat, Anne Puel, Jean-Laurent Casanova, Bernhard Fleckenstein, Stephan Weidinger, Sara S Kilic, Ben-Zion Garty, Amos Etzioni, Bodo Grimbacher
Signal transducer and activator of transcription 3 (STAT3) is a central regulator of immune homeostasis. STAT3 levels are strictly controlled, and STAT3 impairment contributes to several diseases including the monogenic autosomal-dominant hyper-immunoglobulin E (IgE) syndrome (AD-HIES). We investigated patients of four consanguineous families with an autosomal-recessive disorder resembling the phenotype of AD-HIES, with symptoms of immunodeficiency, recurrent infections, skeletal abnormalities, and elevated IgE...
June 15, 2018: Science Immunology
https://www.readbyqxmd.com/read/29906688/in-vitro-and-in-vivo-studies-of-gold-i-azolate-phosphane-complexes-for-the-treatment-of-basal-like-breast-cancer
#6
Valentina Gambini, Martina Tilio, Eunice Wairimu Maina, Cristina Andreani, Caterina Bartolacci, Junbiao Wang, Manuela Iezzi, Stefano Ferraro, Anna Teresa Ramadori, Oumarou Camille Simon, Stefania Pucciarelli, Guojun Wu, Q Ping Dou, Cristina Marchini, Rossana Galassi, Augusto Amici
Basal like breast cancer (BLBC) is a very aggressive subtype of breast cancer giving few chances of survival, against which cisplatin based therapy is a compromise among the anticancer activity, the resistance development and the severe side effects. With the aim of finding new anticancer agents alternative to cisplatin, seven gold(I) azolate/phosphane compounds were evaluated in vitro by MTT tests in human MDA-MB-231, human mammary epithelial HMLE cells overexpressing FoxQ1, and murine A17 cells as models of BLBC...
June 2, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29906536/mahuang-decoction-mitigates-airway-inflammation-and-regulates-il-21-stat3-signaling-pathway-in-rat-asthma-model
#7
Yu He, Xiaohui Lou, Zhan Jin, Li Yu, Ling Deng, Haitong Wan
ETHNOPHARMACOLOGICAL RELEVANCE: Nowadays, bronchial asthma is still a severe disease threatening human health, and it is incumbent upon us to seek effective therapeutic drugs. Mahuang decoction (MHD), a classic famous Chinese prescription, has been used for thousands of years to prevent phlegm from forming, stop coughing and relieve asthma, but the relevant mechanism has not been thoroughly clarified. This study aims to investigate the anti-airway inflammation effect of MHD and the possible molecular mechanism underlying IL21/STAT3 signaling pathway, so as to provide guidance for the treatment of MHD on bronchial asthma...
June 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29905375/sox2-mediated-upregulation-of-cd24-promotes-adaptive-resistance-towards-targeted-therapy-in-melanoma
#8
Laura Hüser, Sachindra, Karol Granados, Aniello Federico, Lionel Larribère, Daniel Novak, Viktor Umansky, Peter Altevogt, Jochen Utikal
Melanoma is often characterized by a constitutively active RAS-RAF-MEK-ERK pathway. For targeted therapy, BRAF inhibitors are available that are powerful in the beginning but resistance occurs rather fast. A better understanding of the mechanisms of resistance is urgently needed to increase the success of the treatment. Here, we observed that SOX2 and CD24 are upregulated upon BRAF inhibitor treatment. A similar upregulation was seen in targeted therapy-resistant, melanoma-derived induced pluripotent cancer cells (iPCCs)...
June 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29904948/crispr-cas9-mediated-knockout-of-hbsag-inhibits-proliferation-and-tumorigenicity-of-hbv-positive-hepatocellular-carcinoma-cells
#9
Jia Song, Xiaochao Zhang, Qianyun Ge, Chaoyi Yuan, Liang Chu, Hui-Fang Liang, Zhibin Liao, Qiumeng Liu, Zhanguo Zhang, Bixiang Zhang
Chronic hepatitis B virus (HBV) infection remains the most common risk factor for hepatocellular carcinoma (HCC). High HBV surface antigen (HBsAg) levels are highly correlated with hepatocarcinogenesis and HBV-associated HCC development. However, the role and detailed mechanisms associated with HBsAg in HCC development remain elusive. In this study, we designed specific single guide RNAs (sgRNAs) targeting the open reading frames, preS1/preS2/S, of the HBV genome and established HBsAg knockout HCC cell lines using the CRISPR/Cas9 system...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29902838/icariside-ii-promotes-the-differentiation-of-adipose-tissue-derived-stem-cells-to-schwann-cells-to-preserve-erectile-function-after-cavernous-nerve-injury
#10
Tao Zheng, Tian-Biao Zhang, Chao-Liang Wang, Wei-Xing Zhang, Dong-Hui Jia, Fan Yang, Yang-Yang Sun, Xiao-Ju Ding, Rui Wang
Icariside II (ICA II) is used in erectile dysfunction treatment. Adipose tissue-derived stem cells (ADSCs) are efficient at improving erectile function. This study aimed to explore the action mechanism of ADSCs in improving erectile function. ADSCs were isolated from the adipose tissues of rats. Cell proliferation was determined using the Cell Counting Kit-8 (CCK-8) assay. The expressions of mRNA and protein were determined separately through qRT-PCR and western blot. The endogenous expressions of related genes were regulated using recombinant plasmids and cell transfection...
June 14, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29901185/salidroside-inhibits-migration-invasion-and-angiogenesis-of-mda%C3%A2-mb-231-tnbc-cells-by-regulating-egfr-jak2-stat3-signaling-via-mmp2
#11
Dong Young Kang, Nipin Sp, Doh Hoon Kim, Youn Hee Joung, Hyo Gun Lee, Young Min Park, Young Mok Yang
The major hallmarks of tumor progression are angiogenesis, migration and metastasis. Among the components of Rhodiola rosea, salidroside (p‑hydroxyphenethyl-β‑d-glucoside) is one of the most potent, and is present in all Rhodiola species. Recent data have revealed the anticancer effects of salidroside; however, the mechanism underlying its ability to inhibit tumor angiogenesis remains unknown. The present study aimed to analyze how salidroside affects major factors involved in breast cancer, and to elucidate its ability to inhibit angiogenesis and invasion...
June 5, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29901173/preliminary-mechanisms-of-regulating-pd%C3%A2-l1-expression-in-non%C3%A2-small-cell-lung-cancer-during-the-emt-process
#12
Fang Li, Tengjiao Zhu, Yao Yue, Xiang Zhu, Jiadong Wang, Li Liang
Non‑small cell lung cancer (NSCLC) is one of the most severe malignant tumor types worldwide. Recent studies have reported an important role of PD‑L1 in mediating immune evasion in the tumor microenvironment. In addition, increasing research has indicated that the expression of PD‑L1 is related to the epithelial‑mesenchymal transition (EMT) process, but the related mechanisms remain to be explored. In the present study, we explored the molecular mechanisms underlying the regulation of PD‑L1 expression during the EMT process in NSCLC cells treated with transforming growth factor‑β1 (TGF‑β1) and fibroblast growth factor 2 (FGF2)...
June 5, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29901157/oct4-promotes-cancer-cell-proliferation-and-migration-and-leads-to-poor-prognosis-associated-with-the-survivin-stat3-pathway-in-hepatocellular-carcinoma
#13
Gang Wang, Hemei Zhou, Zhigang Gu, Quangen Gao, Genhai Shen
Octamer‑binding transcription factor 4 (Oct4) has been identified as a novel transcription factor associated with tumorigenesis, acquisition and maintenance of cancer stem cell characteristics and poor prognosis in tumors. However, the role of Oct4 in tumorigenesis and progression of hepatocellular carcinoma (HCC) has not yet been fully elucidated. In our present study, we observed that the Oct4 expression level was upregulated in HCC specimens as well as in different HCC cell lines. In in vitro experiments, decreased expression of Oct4 by shRNA inhibited the viability and mobility of HCC cells...
June 14, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29901091/suppressive-effects-of-wang%C3%A2-bi-tablet-on-adjuvant%C3%A2-induced-arthritis-in-rats-via-nf%C3%A2-%C3%AE%C2%BAb-and-stat3-signaling-pathways
#14
Yun-Yun Guan, Yeqing Zhang, Li-Xin Liu, Hai-Dong Li, Dan Xue, Wei-Lian Bao, Guan Ye, Xiaoyan Shen
Rheumatoid arthritis (RA) severely affects the quality life of patients due to its high association with disability. Traditional Chinese medicines have been reported to exert notable therapeutic effects on RA. The Chinese medicinal prescription Wang‑Bi Tablet (WB) has been successfully used to clinically treat RA for many years; however, its pharmacological mechanism of action is largely unclear. In the present study, adjuvant‑induced arthritis (AIA) rats were used to evaluate the anti‑inflammatory effects of WB and western blotting was used to explore the molecular mechanisms...
June 8, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29901084/plumbagin-a-natural-naphthoquinone-inhibits-the-growth-of-esophageal-squamous-cell-carcinoma-cells-through-inactivation-of-stat3
#15
Yan Cao, Xiang Yin, Yiping Jia, Bingyan Liu, Shaoqiu Wu, Mingyi Shang
Although plumbagin, a natural naphthoquinone, has exhibited antiproliferative activity in numerous types of cancer, its anticancer potential in esophageal squamous cell carcinoma (ESCC) remains unclear. In the present study, the effect of plumbagin on the growth of ESCC cells was investigated in vitro and in vivo. ESCC cells were treated with plumbagin and tested for cell cycle distribution and apoptosis. The involvement of STAT3 signaling in the effect of plumbagin was examined. The results demonstrated that plumbagin treatment suppressed ESCC cell viability and proliferation, yet normal esophageal epithelial cell viability was not affected...
June 7, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29901083/cxcr7-silencing-inhibits-the-migration-and-invasion-of-human-tumor-endothelial-cells-derived-from-hepatocellular-carcinoma-by-suppressing-stat3
#16
Ye Wu, Lei Tian, Yongle Xu, Minhong Zhang, Shengqing Xiang, Jianguo Zhao, Zhenxia Wang
C-X-C chemokine receptor type 7 (CXCR7) is reported to be overexpressed in tumor endothelial cells (TECs), which are the primary target cells of antivascular chemotherapy. However, the role of CXCR7 in TECs is not fully understood. In the present study, CXCR7 expression was inhibited in TECs derived from hepatocellular carcinoma (HCC) using short hairpin (sh)RNA plasmids to investigate the role of CXCR7 in the regulation of migration and invasion of TECs as well as its underlying mechanisms. The data showed that the downregulation of CXCR7 significantly inhibited the migration and invasion of TECs...
May 31, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29900929/whey-acidic-protein-four-disulfide-core-domain-21-regulate-sepsis-pathogenesis-in-a-mouse-model-and-a-macrophage-cell-line-via-the-stat3-toll-like-receptor-4-tlr4-signaling-pathway
#17
Zhixiang Xie, Zhuangbo Guo, Jianfeng Liu
BACKGROUND Whey acidic protein/four-disulfide core domain 21 (Wfdc21), also known as Lnc-DC, it has been reported to be correlated with immune response. However, the role of Wfdc21 in the pathogenesis of sepsis is still unknown. In the present study, we aimed to investigate the role of Wfdc21 in the pathogenesis of sepsis. MATERIAL AND METHODS The cecal ligation and puncture (CLP)-induced sepsis model was established in Balb/c mice. Animals were euthanized 4, 8, 16, or 24 h after CLP. The glycogen distribution in the kidney and liver was checked by Periodic acid-Schiff (PAS) staining...
June 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29899697/anti-myeloma-effects-of-icariin-are-mediated-through-the-attenuation-of-jak-stat3-dependent-signaling-cascade
#18
Young Yun Jung, Jong Hyun Lee, Dongwoo Nam, Acharan S Narula, Ojas A Namjoshi, Bruce E Blough, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Because of the essential role of signal transducer and activator of transcription 3 (STAT3) in proliferation, anti-apoptosis, and chemoresistance of multiple myeloma (MM), we investigated whether icariin, a prenylated flavonol glycoside, inhibits both constitutive and inducible STAT3 activation in human myeloma cell lines. We noted that icariin could block constitutive STAT3 phosphorylation as well as its nuclear translocation and DNA binding ability in U266 cells. Icariin also suppressed IL-6-induced STAT3 activation through the inhibition of upstream kinases (Janus activated kinase-1 and -2, and c-Src)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29899555/magnolin-promotes-autophagy-and-cell-cycle-arrest-via-blocking-lif-stat3-mcl-1-axis-in-human-colorectal-cancers
#19
Haiyang Yu, Shuangshuang Yin, Shiyue Zhou, Yingying Shao, Jiachen Sun, Xu Pang, Lifeng Han, Yi Zhang, Xiumei Gao, Chengyun Jin, Yuling Qiu, Tao Wang
Magnolin is a multi-bioactive natural compound that possesses underlying anti-cancer properties. However, the mechanisms underlying remain to be elucidated. Here, we report the role of magnolin in suppressing human colorectal cancer (CRC) cells via activating autophagy and cell cycle arrest in vitro and in vivo. Pre-treatment of cells with specific autophagy inhibitor (3-methyladenine) or knockdown of endogenous LC-3B by siRNA significantly abrogates magnolin-induced cell cycle arrest. Molecular validation mechanistically shows that magnolin-induced autophagy and cell cycle arrest in CRC cells is correlated with decreased transcriptional levels of leukemia inhibitory factor (LIF), and we further find that inhibition of LIF decreases phosphorylation level of Stat3 and represses transcriptional expression of Mcl-1...
June 13, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29899261/-c-ebp%C3%AE-promotes-stat3-expression-and-affects-cell-apoptosis-and-proliferation-in-porcine-ovarian-granulosa-cells
#20
Xiaolong Yuan, Xiaofeng Zhou, Yingting He, Yuyi Zhong, Ailing Zhang, Zhe Zhang, Hao Zhang, Jiaqi Li
Previous studies suggest that signal transducer and activator of transcription 3 (STAT3) and CCAAT/enhancer binding protein beta (C/EBPβ) play an essential role in ovarian granulosa cells (GCs) for mammalian follicular development. Several C/EBPβ putative binding sites were previously predicted on the STAT3 promoter in mammals. However, the molecular regulation of C/EBPβ on STAT3 and their effects on cell proliferation and apoptosis remain virtually unexplored in GCs. Using porcine GCs as a model, the 5′-deletion, luciferase report assay, mutation, chromatin immunoprecipitation, Annexin-V/PI staining and EdU assays were applied to investigate the molecular mechanism for C/EBPβ regulating the expression of STAT3 and their effects on the cell proliferation and apoptosis ability...
June 13, 2018: Genes
keyword
keyword
14617
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"