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https://www.readbyqxmd.com/read/29778893/synthesis-of-proline-derived-benzenesulfonamides-a-potent-anti-trypanosoma-brucei-gambiense-agent
#1
David I Ugwu, Uchechukwu C Okoro, Narendra K Mishra
Thousands of death in Africa and other developing nations are still attributed to trypanosomiasis. Excessive sleep has been associated with increased inflammation. We report herein, the synthesis, antitrypanosomal and anti-inflammatory activities of eight new carboxamide derivatives bearing substituted benzenesulfonamides. The base promoted reactions of l-proline and L-4-hydroxyproline with substituted benzenesulfonyl chlorides gave the benzenesulfonamides (11a-h) in excellent yields. Boric acid mediated amidation of the benzenesulfonamides (11a-h) and p-aminobenzoic acid (12) gave the new carboxamides (13a-h) in excellent yields...
May 14, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29778501/the-discrimination-of-geoforensic-trace-material-from-close-proximity-locations-by-organic-profiling-using-hplc-and-plant-wax-marker-analysis-by-gc
#2
G McCulloch, L A Dawson, J M Ross, R M Morgan
There is a need to develop a wider empirical research base to expand the scope for utilising the organic fraction of soil in forensic geoscience, and to demonstrate the capability of the analytical techniques used in forensic geoscience to discriminate samples at close proximity locations. The determination of wax markers from soil samples by GC analysis has been used extensively in court and is known to be effective in discriminating samples from different land use types. A new HPLC method for the analysis of the organic fraction of forensic sediment samples has also been shown recently to add value in conjunction with existing inorganic techniques for the discrimination of samples derived from close proximity locations...
May 16, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29778346/energy-performance-evaluation-of-ultrasonic-pretreatment-of-organic-solid-waste-in-a-pilot-scale-digester
#3
Mazdak Rasapoor, Mehrdad Adl, Saeid Baroutian, Zeynab Iranshahi, Mohammad Pazouki
It has been proven that ultrasonic pretreatment (UP) has positive effect on biogas generation from previous lab-scale studies. However, that is not always the case in larger scale processes. The purpose of this study was to evaluate the effectiveness of UP to biogas generation in terms of anaerobic digestion process and energy efficiency. Parameters including total solids (TS) and ultrasonic treatment operational parameters of organic solid waste (OSW) resulted from our past lab scale UP studies were applied in this study...
April 30, 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29777992/18-years-of-continuous-observation-of-tritium-and-atmospheric-precipitations-in-ramnicu-valcea-romania-a-time-series-analysis
#4
Octavian G Duliu, Carmen Varlam, Muataz Dheyaa Shnawaw
To get more information on the origin of tritium and to evidence any possible presence of anthropogenic sources, between January 1999 and December 2016, the precipitation level and tritium concentration were monthly recorded and investigated by the Cryogenic Institute of Ramnicu Valcea, Romania. Compared with similar data covering a radius of about 1200 km westward, the measurements gave similar results concerning the time evolution of tritium content and precipitation level for the entire time interval excepting the period between 2009 and 2011 when the tritium concentrations showed a slight increase, most probable due to the activity of neighboring experimental pilot plant for tritium and deuterium separation...
May 16, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29777645/-childbirth-is-not-a-sickness-a-woman-should-struggle-to-give-birth-exploring-continuing-popularity-of-home-births-in-western-kenya
#5
Violet Naanyu, Joyce Baliddawa, Beatrice Koech, Julie Karfakis, Nancy Nyagoha
More than 95% of Kenyan women receive antenatal care (ANC) and only 62% access skilled delivery. To explore women's opinion on delivery location, 20 focus group discussions were conducted at an urban and rural setting in western Kenya. Participants included health care workers, traditional birth attendants (TBAs), and women who attended at least four ANC visits and delivered. Six in-depth interviews were also conducted with a combination of women who gave birth in a facility and at home. Discussions were digitally recorded and transcribed for analysis...
March 2018: African Journal of Reproductive Health
https://www.readbyqxmd.com/read/29777145/testicular-sperm-is-superior-to-ejaculated-sperm-for-icsi-in-cryptozoospermia-an-update-systematic-review-and-meta-analysis
#6
Yi-No Kang, Ya-Wen Hsiao, Chien-Yu Chen, Chien-Chih Wu
Intracytoplasmic sperm injection (ICSI) is well established and provides patients with severely impaired sperm quality with an opportunity to father a child. However, previous studies do not clearly indicate whether male with cryptozoospermia should use testicular sperm or ejaculated sperm for ICSI. The newest systematic review of this topic also gave a controversial conclusion that was based on incorrect pooling result. Moreover, two clinical studies published after the systematic review. In the present update systematic review and meta-analysis, a comprehensive citation search for relevant studies was performed using the Cochrane library databases, Embase, Ovid MEDLINE, PubMed, ScienceDirect, Scopus, and Web of Science up to September 2017...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29776897/reach-and-acceptability-of-a-mobile-reminder-strategy-and-facebook-group-intervention-for-weight-management-in-less-advantaged-adolescents-insights-from-the-pralimap-in%C3%A3-s-trial
#7
Laura Saez, Johanne Langlois, Karine Legrand, Marie-Hélène Quinet, Edith Lecomte, Abdou Y Omorou, Serge Briançon
BACKGROUND: Although information and communication technology interventions appear to be a promising means of reducing the health inequality gap in overweight and obesity prevention, research on information and communication technology interventions is lacking outside the Anglo-Saxon world. OBJECTIVE: The aim of this study was to assess the reach and acceptability of 2 information and communication technology interventions delivered as part of a French nutritional program: an SMS text messaging (short message service, SMS) attendance-reminder for collective sessions strategy and a Facebook challenge group...
May 18, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29776345/risk-behavior-in-patients-with-severe-mental-disorders-a-prospective-study-of-121-830-patients-managed-in-rural-households-of-western-china
#8
Yuanyuan Liu, Xiang Liu, Hong Wen, Dan Wang, Xianmei Yang, Weiwei Tang, Yaxi Li, Tao Zhang, Min Yang
BACKGROUND: The management of severe mental disorder (SMD) patients in communities is an important initiative of healthcare reform in China. Yet the effects in terms of risk behavior of patients are unclear, particularly in rural areas. This study aims to examine high risk behaviors, changing trends, and possible associated factors among SMD patients in the rural areas of western China. METHODS: This analysis examined incidence rate (IR) of high risk behavior of 121,830 managed SMD patients in rural area of Sichuan province, based on data from the national system from 2006 to 2013...
May 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29775980/-comparison-of-the-masaoka-koga-classification-with-the-new-tnm-staging-of-the-iaslc-itmig-for-thymoma-and-thymic-carcinoma
#9
Michael Ried, Maria-Magdalena Eicher, Reiner Neu, Dietmar Kraus, Sebastian Inderhees, Alexander Marx, Hans-Stefan Hofmann
BACKGROUND: The Masaoka-Koga classification describes the extent and spread of thymic epithelial malignancies. The objective of this study was to evaluate the Masaoka-Koga and the new TNM-staging system regarding differences in stage distributions, clinical implementation and therapeutic consequences. METHODS: Retrospective analysis of all patients who underwent surgery between January 2005 and December 2015 for thymoma/thymic carcinoma in two centres for thoracic surgery...
May 18, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29775731/targeted-and-controlled-drug-delivery-by-multifunctional-mesoporous-silica-nanoparticles-with-internal-fluorescent-conjugates-and-external-polydopamine-and-graphene-oxide-layers
#10
Anh-Vy Tran, KyuHwan Shim, Thu-Thao Vo Thi, Jeong-Keun Kook, Seong Soo A An, Sang-Wha Lee
This study demonstrated the targeted delivery and controlled release of cisplatin drug molecules from doubly decorated mesoporous silica nanoparticles (MSNs), which were internally grafted with fluorescent conjugates and externally coated with polydopamine (PDA) and graphene oxide (GO) layers. The brush-like internal conjugates conferred fluorescent functionality and high capacity of cisplatin loading into MSNs, as well as contributing to a sustained release of the cisplatin through a porous channel with the assistance of external PDA layer...
May 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29775433/asian-american-mothers-demographic-characteristics-by-maternal-place-of-birth-and-asian-subgroup-2016
#11
Anne K Driscoll
This report describes women of Asian descent who gave birth in the United States in 2016. The 2016 vital statistics natality file was used to compare demographic characteristics of non-Hispanic Asian mothers across six Asian subgroups-Asian Indian, Chinese, Filipino, Japanese, Korean, and Vietnamese-both overall and by whether they were U.S.-born or born outside the United States. In addition, non-Hispanic Asian mothers were compared with the overall U.S. population of mothers. Overall, 6.4% of U.S. births in 2016 were to non-Hispanic Asian women...
April 2018: National Vital Statistics Reports
https://www.readbyqxmd.com/read/29775322/prediction-of-human-cytochrome-p450-inhibition-using-a-multi-task-deep-autoencoder-neural-network
#12
Xiang Li, Youjun Xu, Luhua Lai, Jianfeng Pei
Adverse side effects of drug-drug interactions induced by human cytochrome P450 (CYP450) inhibition is an important consideration in drug discovery. It is highly desirable to develop computational models that can predict the inhibitive effect of a compound against a specific CYP450 isoform. In this study, we developed a multi-task model for concurrent inhibition prediction of five major CYP450 isoforms, namely 1A2, 2C9, 2C19, 2D6, and 3A4. The model was built by training multi-task autoencoder deep neural network (DNN) on a large dataset containing more than 13000 compounds, extracted from PubChem BioAssay Database...
May 18, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29774906/reactivity-of-a-dearomatised-pincer-co-ii-br-complex-with-pnc-nhc-donors-alkylation-and-si-h-bond-activation-via-metal-ligand-cooperation
#13
Thomas Simler, Sylvie Choua, Andreas A Danopoulos, Pierre Braunstein
The double aminolysis reaction of [Co{N(SiMe3)2}2] by the salt 1-(6-((dicyclohexylphosphaneyl)methyl)pyridin-2-yl)-3-(2,6-diisopropylphenyl)-1H-imidazol-3-ium bromide, which contains one phosphane, one pyridine and one imidazolium groups, of formula [o-Cy2PCH2(C5H3N)(o-C3H3N2DiPP)]Br and abbreviated as (CyPNpyrCim)Br, was previously shown to afford the Co(ii) complex [Co(CyP*NaCNHC)Br] (1) containing a dearomatised picolyl moiety in the tridentate, anionic donor ligand CyP*NaCNHC (Na = anionic amido, P* = vinylic P donor)...
May 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29774287/prevalence-of-gastrointestinal-helminth-infections-of-dog-in-enugu-state-south-eastern-nigeria
#14
I K Idika, E C Onuorah, C F Obi, P U Umeakuana, C O Nwosu, D N Onah, S N Chiejina
The prevalence of gastrointestinal helminth infections of dog in Enugu State, South Eastern Nigeria was studied retrospectively and prospectively. In the retrospective study, records of all diagnosed helminth infections of dogs brought to the University of Nigeria Veterinary Teaching Hospital, Nsukka from January, 2006 to September 2013 were collated and analyzed. The prospective study was carried out between October 2013 and July 2014 by examination of 263 faecal samples collected per rectum from dogs presented to a purposively selected Veterinary Clinics in Enugu metropolis and the Veterinary Teaching Hospital of the University of Nigeria, Nsukka...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774245/evaluation-of-phylogenetic-reconstruction-methods-using-bacterial-whole-genomes-a-simulation-based-study
#15
John A Lees, Michelle Kendall, Julian Parkhill, Caroline Colijn, Stephen D Bentley, Simon R Harris
Background : Phylogenetic reconstruction is a necessary first step in many analyses which use whole genome sequence data from bacterial populations. There are many available methods to infer phylogenies, and these have various advantages and disadvantages, but few unbiased comparisons of the range of approaches have been made. Methods : We simulated data from a defined "true tree" using a realistic evolutionary model. We built phylogenies from this data using a range of methods, and compared reconstructed trees to the true tree using two measures, noting the computational time needed for different phylogenetic reconstructions...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/29773529/development-of-a-just-in-time-adaptive-mhealth-intervention-for-insomnia-usability-study
#16
I Wayan Pulantara, Bambang Parmanto, Anne Germain
BACKGROUND: Healthy sleep is a fundamental component of physical and brain health. Insomnia, however, is a prevalent sleep disorder that compromises functioning, productivity, and health. Therefore, developing efficient treatment delivery methods for insomnia can have significant societal and personal health impacts. Cognitive behavioral therapy for insomnia (CBTI) is the recommended first-line treatment of insomnia but access is currently limited for patients, since treatment must occur in specialty sleep clinics, which suffer from an insufficient number of trained clinicians...
May 17, 2018: JMIR Human Factors
https://www.readbyqxmd.com/read/29773323/primary-laryngeal-tuberculosis-our-experiences-at-a-tertiary-care-teaching-hospital-in-eastern-india
#17
Santosh Kumar Swain, Ishwar Chandra Behera, Mahesh Chandra Sahu
INTRODUCTION: Primary laryngeal tuberculosis is a chronic bacterial infection of the larynx by Mycobacterium tuberculosis without affecting the lungs. It is a rare type of extrapulmonary tuberculosis seen in clinical practice. OBJECTIVES: This study aimed to evaluate the clinical presentation, diagnosis, and treatment of primary laryngeal tuberculosis at a tertiary care teaching hospital in eastern India. MATERIALS AND METHODS: This is a retrospective study of 11 cases of primary laryngeal tuberculosis managed between December 2013 and January 2018...
May 14, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29773171/determination-of-toxic-and-essential-trace-elements-in-serum-of-healthy-and-hypothyroid-respondents-by-icp-ms-a-chemometric-approach-for-discrimination-of-hypothyroidism
#18
Aleksandar Stojsavljević, Jelena Trifković, Zorica Rasić-Milutinović, Dragana Jovanović, Gradimir Bogdanović, Jelena Mutić, Dragan Manojlović
Inductively coupled plasma-mass spectrometry ((ICP-MS)) was used to determine three toxic (Ni, As, Cd) and six essential trace elements (Cr, Mn, Co, Cu, Zn, Se) in blood serum of patients with hypothyroidism (Hy group) and healthy people (control group), in order to set the experimental conditions for accurate determination of a unique profile of these elements in hypothyroidism. Method validation was performed with standard reference material of the serum by varying the sample treatment with both standard and collision mode for analysis of elements isotopes...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29773133/evaluation-of-tritrichomonas-foetus-infection-clearance-in-heifers-immunized-with-a-single-intravaginal-dose-of-formaldehyde-fixed-strain-b1-cells
#19
Florencia Gracia Martinez, Lumila Fuchs, Rosana Ramirez, Javier Breccia, Jorge Oyhenart
Vaccines against Tritrichomonas foetus have been shown to reduce the time of infection after natural or experimental exposure. The object of this study was to assess the protection against T. foetus infection conferred by a single vaginal instillation of formaldehyde fixed T. foetus cells. Aberdeen Angus virgin heifers were randomly allocated to 3 groups of 12 individuals to receive placebo or formaldehyde fixed T. foetus cells prepared following one of two procedures (formalin or freshly prepared solution) and six weeks later they were challenged with 106 T...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29772708/microstructure-evolution-and-mechanical-behavior-of-2219-aluminum-alloys-additively-fabricated-by-the-cold-metal-transfer-process
#20
Xuewei Fang, Lijuan Zhang, Hui Li, Chaolong Li, Ke Huang, Bingheng Lu
In this research, four different welding arc modes including conventional cold metal transfer (CMT), CMT-Pulse (CMT-P), CMT-Advanced (CMT-ADV), and CMT pulse advanced (CMT-PADV) were used to deposit 2219-Al wire. The effects of different arc modes on porosity, pore size distribution, microstructure evolution, and mechanical properties were thoroughly investigated. The statistical analysis of the porosity and its size distribution indicated that the CMT-PADV process gave the smallest pore area percentage and pore aspect ratio, and had almost no larger pores...
May 16, 2018: Materials
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