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https://www.readbyqxmd.com/read/27926911/first-rank-symptoms-in-methamphetamine-psychosis-and-schizophrenia
#1
James Shelly, Anne Uhlmann, Heidi Sinclair, Fleur M Howells, Goodman Sibeko, Don Wilson, Dan J Stein, Henk Temmingh
BACKGROUND: Methamphetamine psychosis (MAP) symptomatology has been described as indistinguishable from that of schizophrenia (SZ), yet research comparing these two disorders on specific psychotic symptoms such as schneiderian first-rank symptoms (FRS) is lacking. We aimed to determine and compare the occurrence and associations of FRS in patients diagnosed with MAP and with SZ. SAMPLING AND METHOD: Data from SCID-I interviews performed on patients with either a diagnosis of SZ or MAP were compared...
December 8, 2016: Psychopathology
https://www.readbyqxmd.com/read/27925220/relationship-between-inner-dialog-and-ideas-of-reference-and-the-mediating-role-of-dissociation
#2
Gloria Bellido-Zanin, Salvador Perona-Garcelán, Cristina Senín-Calderón, Ana María López-Jiménez, Juan Francisco Rodríguez-Testal
Recent lines of research have begun to concentrate on internal dialogue and its relationship to a diversity of psychopathological phenomena present in psychotic disorders. This study was intended as a preliminary exploration of the relationship of internal dialogue, dissociation and ideas of reference. To do this, a sample of 318 students filled in an internal dialogue scale (the VISQ, McCarthy-Jones & Fernyhough), one for dissociation (DES-II, Carlson & Putnam) and another for ideas of reference (REF, Lenzenweger, Bennett & Lilenfeld)...
December 7, 2016: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/27918911/cortical-amygdala-volumetric-ratios-predict-onset-of-symptoms-of-psychosis-in-22q11-2-deletion-syndrome
#3
David Berhanu, Leah M Mattiaccio, Kevin M Antshel, Wanda Fremont, Frank A Middleton, Wendy R Kates
Dysfunction of cortical circuitry involving prefrontal cortex, cingulate gyrus and mesial temporal lobe has been implicated in the pathophysiology of psychotic symptoms. 22q11.2 deletion syndrome (22q11DS) is a neurogenetic disorder that comports a 25-fold increased risk of developing psychosis. Morphological changes in the neuroanatomy of this syndrome may represent a biological risk factor for the development of psychosis. The present study explored ratios between cortical volumes and the amygdala. We also explored relationships between these ratios and the eventual development of psychosis in youth with 22q11DS...
November 25, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27917874/discovery-synthesis-biological-evaluation-and-structure-based-optimization-of-novel-piperidine-derivatives-as-acetylcholine-binding-protein-ligands
#4
Jian Shen, Xi-Cheng Yang, Ming-Cheng Yu, Li Xiao, Xun-Jie Zhang, Hui-Jiao Sun, Hao Chen, Guan-Xin Pan, Yu-Rong Yan, Si-Chen Wang, Wei Li, Lu Zhou, Qiong Xie, Lin-Qian Yu, Yong-Hui Wang, Li-Ming Shao
The homomeric α7 nicotinic receptor (α7 nAChR) is widely expressed in the human brain that could be activated to suppress neuroinflammation, oxidative stress and neuropathic pain. Consequently, a number of α7 nAChR agonists have entered clinical trials as anti-Alzheimer's or anti-psychotic therapies. However, high-resolution crystal structure of the full-length α7 receptor is thus far unavailable. Since acetylcholine-binding protein (AChBP) from Lymnaea stagnalis is most closely related to the α-subunit of nAChRs, it has been used as a template for the N-terminal domain of α-subunit of nAChR to study the molecular recognition process of nAChR-ligand interactions, and to identify ligands with potential nAChR-like activities...
December 5, 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27917762/revisiting-an-old-foe-the-face-of-psychosis-in-neurosyphilis
#5
Y Moolla, J Abdul
A delusional, agitated middle-aged man presented to hospital with a tenacious psychotic episode. Upon appropriate therapy for neurosyphilis, dramatic resolution of this brief episode ensued, prompting a literature review of psychosis associated with neurosyphilis.
December 1, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27917569/distinct-intrinsic-functional-brain-network-abnormalities-in-methamphetamine-dependent-patients-with-and-without-a-history-of-psychosis
#6
Jonathan C Ipser, Anne Uhlmann, Paul Taylor, Brian H Harvey, Don Wilson, Dan J Stein
Chronic methamphetamine use is associated with executive functioning deficits that suggest dysfunctional cognitive control networks (CCNs) in the brain. Likewise, abnormal connectivity between intrinsic CCNs and default mode networks (DMNs) has also been associated with poor cognitive function in clinical populations. Accordingly, we tested the extent to which methamphetamine use predicts abnormal connectivity between these networks, and whether, as predicted, these abnormalities are compounded in patients with a history of methamphetamine-associated psychosis (MAP)...
December 5, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27916286/relating-therapy-for-distressing-auditory-hallucinations-a-pilot-randomized-controlled-trial
#7
Mark Hayward, Anna-Marie Jones, Leanne Bogen-Johnston, Neil Thomas, Clara Strauss
Auditory hallucinations (AH) are a common and distressing experience and patients report distress reduction to be a priority. Relating Therapy adopts a symptom-specific and mechanism focused approach to the reduction of AH distress. We conducted this single-blind, pragmatic, parallel groups, superiority pilot RCT within a single mental health centre in the UK. Patients (18+years) with persistent and distressing AH, irrespective of diagnosis were randomly allocated to receive either Relating Therapy and Treatment-as-usual (RT) or Treatment as-usual alone (TAU)...
December 1, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27914246/tract-based-analysis-of-white-matter-integrity-in-psychotic-and-nonpsychotic-bipolar-disorder
#8
Andrew Ji, Douglass Godwin, Jerrel Rutlin, Sridhar Kandala, Joshua S Shimony, Daniel Mamah
BACKGROUND: At least 50% of individuals with bipolar disorder (BD) present with psychosis during their lifetime. Psychotic symptoms have sometimes been linked to specific genetic and phenotypic markers. This study aims to explore potential differences between bipolar disorder subtypes by measuring white matter integrity of the brain and relationships with clinical measures. METHODS: Diffusion tensor imaging and clinical measures were acquired from 102 participants, grouped as psychotic bipolar disorder (PBD) (n=48), non-psychotic bipolar disorder (NBD) (n=24), and healthy controls (n=30)...
November 27, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27914035/mobilization-of-peripheral-blood-stem-cells-and-changes-in-the-concentration-of-plasma-factors-influencing-their-movement-in-patients-with-panic-disorder
#9
Marcin Jabłoński, Jolanta Kucharska Mazur, Maciej Tarnowski, Barbara Dołęgowska, Daniel Pędziwiatr, Ewa Kubiś, Marta Budkowska, Daria Sałata, Justyna Pełka Wysiecka, Arkadiusz Kazimierczak, Artur Reginia, Mariusz Z Ratajczak, Jerzy Samochowiec
In this paper we examined whether stem cells and factors responsible for their movement may serve as new biological markers of anxiety disorders. The study was carried out on a group of 30 patients diagnosed with panic disorder (examined before and after treatment), compared to 30 healthy individuals forming the control group. We examined the number of circulating HSCs (hematopoetic stem cells) (Lin-/CD45 +/CD34 +) and HSCs (Lin-/CD45 +/AC133 +), the number of circulating VSELs (very small embryonic-like stem cells) (Lin-/CD45-/CD34 +) and VSELs (Lin-/CD45-/AC133 +), as well as the concentration of complement components: C3a, C5a and C5b-9, SDF-1 (stromal derived factor) and S1P (sphingosine-1-phosphate)...
December 2, 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/27913580/responding-to-challenges-for-people-with-psychotic-illness-updated-evidence-from-the-survey-of-high-impact-psychosis
#10
REVIEW
Vera A Morgan, Anna Waterreus, Vaughan Carr, David Castle, Martin Cohen, Carol Harvey, Cherrie Galletly, Andrew Mackinnon, Patrick McGorry, John J McGrath, Amanda L Neil, Suzy Saw, Johanna C Badcock, Debra L Foley, Geoff Waghorn, Sarah Coker, Assen Jablensky
OBJECTIVE: The objective is to summarise recent findings from the 2010 Australian Survey of High Impact Psychosis (SHIP) and examine their implications for future policy and planning to improve mental health, physical health and other circumstances of people with a psychotic disorder. METHODS: Survey of High Impact Psychosis collected nationally representative data on 1825 people with psychotic illness. Over 60 papers have been published covering key challenges reported by participants: financial problems, loneliness and social isolation, unemployment, poor physical health, uncontrolled symptoms of mental illness, and lack of stable, suitable housing...
December 1, 2016: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/27913162/intranasal-delivery-of-antipsychotic-drugs
#11
REVIEW
Yogesh K Katare, Justin E Piazza, Jayant Bhandari, Ritesh P Daya, Kosalan Akilan, Madeline J Simpson, Todd Hoare, Ram K Mishra
Antipsychotic drugs are used to treat psychotic disorders that afflict millions globally and cause tremendous emotional, economic and healthcare burdens. However, the potential of intranasal delivery to improve brain-specific targeting remains unrealized. In this article, we review the mechanisms and methods used for brain targeting via the intranasal (IN) route as well as the potential advantages of improving this type of delivery. We extensively review experimental studies relevant to intranasal delivery of therapeutic agents for the treatment of psychosis and mental illnesses...
November 29, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27910133/physical-restraints-and-associations-with-neuropsychiatric-symptoms-and-personal-characteristics-in-residential-care-a-cross-sectional-study
#12
Marja Kuronen, Hannu Kautiainen, Pertti Karppi, Sirpa Hartikainen, Hannu Koponen
BACKGROUND: Physical restraints are widely used in residential care. The objective was to investigate restraint use and its associations with neuropsychiatric symptoms and personal characteristics in residential care. METHODS: Data were collected in the South Savo Hospital District from 66 of 68 public or private institutions providing long-term residential care. Nurses assessed the use of physical restraints and neuropsychiatric symptoms (NPS) included in the symptom list of the Neuropsychiatric Inventory (NPI)...
December 2, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27909826/profile-and-determinants-of-disability-in-psychotic-disorders-in-nigeria
#13
Victor Olufolahan Lasebikan, Olatunde Ayinde
We compared profile and predictors of disability among 210 patients with schizophrenia, schizoaffective disorder, bipolar I disorder with psychosis and depression with psychosis, respectively in a Nigerian clinical population, using the WHO Disability Assessment Schedule, (2.0). Severity of psychosis was determined with Positive and Negative Symptoms Scale, functioning was assessed using the Global Assessment of Functioning Scale, medication adherence with the Medication Adherence Questionnaire. Analyses were by SPSS 20...
December 1, 2016: Community Mental Health Journal
https://www.readbyqxmd.com/read/27909449/association-between-dsm-iv-anxiety-disorders-and-suicidal-behaviors-in-a-community-sample-of-south-korean-adults
#14
Seong-Jin Cho, Jin Pyo Hong, Jun-Young Lee, Jeong Soo Im, Kyoung-Sae Na, Jee Eun Park, Maeng Je Cho
OBJECTIVE: There are conflicting reports about whether individual anxiety disorders are independently associated with suicidal ideation and suicide attempts. We examined whether anxiety disorders are related to suicidal ideation and suicide attempts in a community sample of South Korean adults. METHODS: In-person interviews based on the South Korean version of the Composite International Diagnostic Interview were conducted to diagnose mental disorders. Multivariate logistic regression analysis was performed to examine whether anxiety disorders were associated with suicidal ideation and suicide attempts...
November 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27909250/conditional-disclosure-on-pathways-to-care-coping-preferences-of-young-people-at-risk-of-psychosis
#15
Petra C Gronholm, Graham Thornicroft, Kristin R Laurens, Sara Evans-Lacko
The interrelationship between stigma and help-seeking is under-researched among children and adolescents. This study explored stigma in relation to pathways to care among young people putatively in an early stage of increased risk of developing psychotic disorders. "Pathways to care" was defined as help-seeking and support from informal and formal resources, and increased risk was determined through the presence of persistent psychotic-like experiences and internalizing/externalizing psychopathology. Twenty-nine qualitative interviews were analyzed using thematic analysis...
November 30, 2016: Qualitative Health Research
https://www.readbyqxmd.com/read/27908296/smoking-in-pregnancy-adolescent-mental-health-and-cognitive-performance-in-young-adult-offspring-results-from-a-matched-sample-within-a-finnish-cohort
#16
Hugh Ramsay, Jennifer H Barnett, Graham K Murray, Pirjo Mäki, Tuula Hurtig, Tanja Nordström, Jouko Miettunen, Vesa Kiviniemi, Solja Niemelä, Zdenka Pausova, Tomas Paus, Juha Veijola
BACKGROUND: The association between prenatal exposure to maternal cigarette smoking (PEMCS) and adult cognition is debated, including if there are differences according to sex. We aimed to determine if there are associations between PEMCS and cognition in early adulthood in men and women and examine if observed associations were mediated by adolescent mental health factors that are associated with cognition, namely psychotic-like experiences (PLEs), inattention and hyperactivity, and other externalizing behaviors...
December 1, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27907276/clinical-course-of-methamphetamine-induced-psychotic-disorder-in-a-3-month-follow-up
#17
Sakineh Javadian, Amir Shabani, Seyed Vahid Shariat
Objective: To assess the clinical course of patients with methamphetamine-induced psychotic disorder (MIPD) and any possible predictors of the clinical course in a 3-month follow-up. Methods: This prospective cohort study included 50 patients (7 female, 43 male) with MIPD and was performed from September 2014 to October 2015. Patients were assessed during hospitalization and in a follow-up visit 3 months later. Diagnoses were made using interviews based on the Structured Clinical Interview for DSM-IV Axis I Disorders...
November 3, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27906415/frontal-lobe-syndrome-with-psychotic-symptoms-secondary-to-a-giant-meningioma-in-a-38-year-old-man
#18
Héctor Cabello-Rangel, Lina Díaz-Castro
No abstract text is available yet for this article.
November 2016: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/27906088/folie-%C3%A3-deux-and-its-interaction-with-early-life-stress-a-case-report
#19
Alessandra Vargas Alves Nunes, Sandra Odebrecht Vargas Nunes, Talita Strano, Gilberto Pascolat, Gustavo Manoel Schier Doria, Mauricio Nasser Ehlke
BACKGROUND: Folie à deux is a very rare psychiatric syndrome in which a psychotic symptom is transmitted from one individual to another. We present a case of folie à deux occurring during childhood, which is not an usual presentation of this syndrome. In this case, the disorder is correlated with child abuse and neglect, which possibly had a role in the development of the symptoms in our case. CASE PRESENTATION: We present a case of folie à deux between an "induced" 9-year-old black Brazilian boy and the "inducer", his grandmother...
December 1, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27905362/-characteristics-of-parkinson-s-disease-course-in-the-heterozygous-carriage-of-mutations-in-the-glucocerebrosidase-a-gene
#20
O A Gan'kina, E E Vasenina, O S Levin, E Yu Fedotova, S N Illarioshkin
Parkinson's disease (PD) is a common neurodegenerative disease. Literature sources indicate the association of PD and mutations in the glucocerebrosidase A (GBA) gene. According to our study, the frequency of the two most common mutations in the GBA gene, N370S and L444P, is 1.85%. Mutation carriers have slower progression of motor symptoms, but are more likely to develop drug-induced motor fluctuations and dyskinesia. In carriers of GBA mutations, the severity of cognitive impairment corresponds to age-matched patients without mutations...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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