keyword
https://read.qxmd.com/read/38536048/mixed-connective-tissue-disease-presenting-with-psychosis-a-case-report
#1
JOURNAL ARTICLE
Nikhil Tondehal, Arnab Sengupta, Kavya Mohankumar, Chintan Trivedi, Zeeshan Mansuri, Shailesh Jain
Mixed connective tissue disease (MCTD) is a systemic autoimmune disease with features overlapping multiple autoimmune disorders. One study found that over 55% of patients with MCTD experienced neuropsychiatric symptoms, the most common of which was an "aseptic meningitis-like syndrome." We present a case of a 17-year-old adolescent girl presenting with abnormal speech and behavior, auditory hallucinations, and paranoid delusions after an isolated episode of fever. She was treated for her psychotic symptoms but later developed symptoms resembling neuroleptic malignant syndrome...
April 1, 2024: Journal of Nervous and Mental Disease
https://read.qxmd.com/read/38534050/antipsychotic-use-and-psychiatric-hospitalization-in-first-episode-non-affective-psychosis-and-cannabis-use-disorder-a-swedish-nationwide-cohort-study
#2
JOURNAL ARTICLE
Alexander Denissoff, Heidi Taipale, Jari Tiihonen, Marta Di Forti, Ellenor Mittendorfer-Rutz, Antti Tanskanen, Antti Mustonen, Solja Niemelä
BACKGROUND AND HYPOTHESIS: There is a paucity of research on treatment outcomes of patients with psychosis and cannabis use disorder (CUD). We aimed to compare the effectiveness of antipsychotics in reducing the risk of hospitalization in patients with first-episode psychosis (FEP) and co-occurring CUD. STUDY DESIGN: We utilized a nationwide Swedish cohort of patients with longitudinal register data from the year 2006 to 2021. Participants were patients with FEP and co-occurring CUD (n = 1820, 84...
March 26, 2024: Schizophrenia Bulletin
https://read.qxmd.com/read/38533562/computational-synaptic-modeling-of-pitch-and-duration-mismatch-negativity-in-first-episode-psychosis-reveals-selective-dysfunction-of-the-n-methyl-d-aspartate-receptor
#3
JOURNAL ARTICLE
F López-Caballero, R Auksztulewicz, Z Howard, R E Rosch, J Todd, D F Salisbury
Mismatch negativity (MMN) to pitch (pMMN) and to duration (dMMN) deviant stimuli is significantly more attenuated in long-term psychotic illness compared to first-episode psychosis (FEP). It was recently shown that source-modeling of magnetically recorded MMN increases the detection of left auditory cortex MMN deficits in FEP, and that computational circuit modeling of electrically recorded MMN also reveals left-hemisphere auditory cortex abnormalities. Computational modeling using dynamic causal modeling (DCM) can also be used to infer synaptic activity from EEG-based scalp recordings...
March 27, 2024: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://read.qxmd.com/read/38532012/immunophenotypes-in-psychosis-is-it-a-premature-inflamm-aging-disorder
#4
REVIEW
Song Chen, Yunlong Tan, Li Tian
Immunopsychiatric field has rapidly accumulated evidence demonstrating the involvement of both innate and adaptive immune components in psychotic disorders such as schizophrenia. Nevertheless, researchers are facing dilemmas of discrepant findings of immunophenotypes both outside and inside the brains of psychotic patients, as discovered by recent meta-analyses. These discrepancies make interpretations and interrogations on their roles in psychosis remain vague and even controversial, regarding whether certain immune cells are more activated or less so, and whether they are causal or consequential, or beneficial or harmful for psychosis...
March 26, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38531873/associations-between-antipsychotics-induced-weight-gain-and-brain-networks-of-impulsivity
#5
JOURNAL ARTICLE
Claire Grosu, Paul Klauser, Daniella Dwir, Ines Khadimallah, Yasser Alemán-Gómez, Nermine Laaboub, Marianna Piras, Margot Fournier, Martin Preisig, Philippe Conus, Bogdan Draganski, Chin B Eap
Given the unpredictable rapid onset and ubiquitous consequences of weight gain induced by antipsychotics, there is a pressing need to get insights into the underlying processes at the brain system level that will allow stratification of "at risk" patients. The pathophysiological hypothesis at hand is focused on brain networks governing impulsivity that are modulated by neuro-inflammatory processes. To this aim, we investigated brain anatomy and functional connectivity in patients with early psychosis (median age: 23 years, IQR = 21-27) using anthropometric data and magnetic resonance imaging acquired one month to one year after initiation of AP medication...
March 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38531581/behavioural-mental-health-interventions-delivered-in-the-emergency-department-for-suicide-overdose-and-psychosis-a-scoping-review
#6
JOURNAL ARTICLE
Shannon M Nugent, Johanna Anderson, Sarah K Young
OBJECTIVE: To identify and describe evidence on brief emergency department (ED)-delivered behavioural and care process interventions among patients presenting with suicide attempt or acute ideation, substance overdose or psychosis. DESIGN: We employed a scoping review design and searched multiple data sources, clinical trial registries and references lists through March 2023. We included English-language trials and rigorously designed observational studies. In alignment with scoping review guidelines, we did not assess the quality of included studies or rate the strength of evidence of intervention effectiveness...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531162/diagnostic-shift-in-first-episode-psychosis-results-from-the-2-year-follow-up-of-the-parma-early-psychosis-program
#7
JOURNAL ARTICLE
Lorenzo Pelizza, Emanuela Leuci, Anna Caterina Leucci, Emanuela Quattrone, Silvia Azzali, Simona Pupo, Enrico Plazzi, Giuseppina Paulillo, Pietro Pellegrini, Marco Menchetti
PURPOSE: Although the stability of current diagnostic criteria for people with First Episode Psychosis (FEP) is essential for treatment, it still remains poorly investigated. As its examination necessarily requires a prospective evaluation of diagnostic trajectories, the aims of the current longitudinal investigation were: (a) to assess diagnostic changes in an Italian FEP population treated within an "Early Intervention in Psychosis" service during a 2-year follow-up period, and (b) to identify potential sociodemographic and clinical moderators of diagnostic instability at entry...
March 25, 2024: Schizophrenia Research
https://read.qxmd.com/read/38531157/association-between-discrimination-and-subsequent-psychotic-experiences-in-patients-with-covid-19-a-cohort-study
#8
JOURNAL ARTICLE
Zui Narita, Megumi Hazumi, Mayumi Kataoka, Kentaro Usuda, Daisuke Nishi
Although cross-sectional studies have suggested that discrimination has a negative impact on the mental health of patients with COVID-19, no cohort studies with longitudinal data have established a causal relationship. Therefore, this study aimed to investigate the association between COVID-19-related discrimination and subsequent psychotic experiences in individuals who had contracted the disease. Secondary outcomes were PTSD symptoms, psychological distress, and suicidal ideation. We utilized inverse probability weighting and marginal structural models with robust standard errors to analyze the association, accounting for confounders and loss to follow-up...
March 25, 2024: Schizophrenia Research
https://read.qxmd.com/read/38530896/automating-the-analysis-of-facial-emotion-expression-dynamics-a-computational-framework-and-application-in-psychotic-disorders
#9
JOURNAL ARTICLE
Nathan T Hall, Michael N Hallquist, Elizabeth A Martin, Wenxuan Lian, Katherine G Jonas, Roman Kotov
Facial emotion expressions play a central role in interpersonal interactions; these displays are used to predict and influence the behavior of others. Despite their importance, quantifying and analyzing the dynamics of brief facial emotion expressions remains an understudied methodological challenge. Here, we present a method that leverages machine learning and network modeling to assess the dynamics of facial expressions. Using video recordings of clinical interviews, we demonstrate the utility of this approach in a sample of 96 people diagnosed with psychotic disorders and 116 never-psychotic adults...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38529082/identification-of-psychosis-risk-and-diagnosis-of-first-episode-psychosis-advice-for-clinicians
#10
REVIEW
Nancy B Lundin, Alexandra M Blouin, Henry R Cowan, Aubrey M Moe, Heather M Wastler, Nicholas J K Breitborde
Early detection of psychotic-spectrum disorders among adolescents and young adults is crucial, as the initial years after psychotic symptom onset encompass a critical period in which psychosocial and pharmacological interventions are most effective. Moreover, clinicians and researchers in recent decades have thoroughly characterized psychosis-risk syndromes, in which youth are experiencing early warning signs indicative of heightened risk for developing a psychotic disorder. These insights have created opportunities for intervention even earlier in the illness course, ideally culminating in the prevention or mitigation of psychosis onset...
2024: Psychology Research and Behavior Management
https://read.qxmd.com/read/38528531/long-acting-injectable-depot-buprenorphine-from-a-harm-reduction-perspective-in-patients-with-ongoing-substance-use-and-multiple-psychiatric-comorbidities-a-qualitative-interview-study
#11
JOURNAL ARTICLE
Björn Johnson, Bodil Monwell, Andrea Johansson Capusan
BACKGROUND: Long-acting injectable depot buprenorphine may increase access to opioid agonist treatment (OAT) for patients with opioid use disorder in different treatment phases. The aim of this study was to explore the experiences of depot buprenorphine among Swedish patients with ongoing substance use and multiple psychiatric comorbidities. METHOD: Semi-structured qualitative interviews were conducted with OAT patients with experience of depot buprenorphine. Recruitment took place at two OAT clinics with a harm reduction focus, specializing in the treatment of patients with ongoing substance use and multiple comorbidities...
March 25, 2024: Harm Reduction Journal
https://read.qxmd.com/read/38527863/using-implementation-science-to-operate-as-a-learning-health-system-to-improve-outcomes-in-early-psychosis
#12
JOURNAL ARTICLE
Bo Kim, Margaret Guyer, Matcheri Keshavan
AIM: Early interventions are well understood to improve psychosis outcomes, but their successful implementation remains limited. This article introduces a three-step roadmap for advancing the implementation of evidence-based practices to operate as a learning health system, which can be applied to early interventions for psychosis and is intended for an audience that is relatively new to systematic approaches to implementation. METHODS: The roadmap is grounded in implementation science, which specializes in methods to promote routine use of evidence-based innovations...
March 25, 2024: Early Intervention in Psychiatry
https://read.qxmd.com/read/38526405/prodromal-or-factitious-psychosis-a-cautionary-tale-in-the-era-of-increasing-social-media-use-by-vulnerable-individuals
#13
JOURNAL ARTICLE
Leo Bastiaens, Stephanie Cristofano-Casella, Jesse Bastiaens
Research on the prodromal phase of schizophrenia has been ongoing for several decades and, more recently, findings from this research are being incorporated into everyday psychiatric practice, such as the use of interviews to evaluate prodromal symptomatology. This evolution is happening in the midst of an explosion of social media use by teenagers and young adults, increasing the exposure of youth to portrayals of psychiatric experiences. For example, reports from around the world of "TIK-TOK tics" emphasize the role of social media in the "creation" of psychiatric symptoms...
March 1, 2024: Journal of Psychiatric Practice
https://read.qxmd.com/read/38526398/psychotic-and-somatic-symptoms-are-frequent-in-refugees-with-posttraumatic-stress-disorder-a-narrative-review
#14
REVIEW
Matthieu Gasnier, Anthony Aouizerat, Kenneth Chappell, Thierry Baubet, Emmanuelle Corruble
OBJECTIVE: In 2021, 89.3 million refugees were vulnerable to posttraumatic stress disorder (PTSD) after exposure to multiple and repeated traumatic experiences. The recent war in Ukraine provoked 7 million refugees to flee their homes. Specific clinical presentations of PTSD in refugee populations may not be familiar to most physicians. The goal of this review is to describe the diagnosis and specific clinical features of PTSD in refugees. METHODS: This narrative review of 263 articles explores 3 PTSD diagnoses that are frequently described in refugee populations and that have been observed in our clinical practices: complex PTSD, PTSD with psychotic symptoms, and PTSD with somatic symptoms...
March 1, 2024: Journal of Psychiatric Practice
https://read.qxmd.com/read/38524477/intramolecular-friedel-crafts-reaction-with-trifluoroacetic-acid-synthesizing-some-new-functionalized-9-aryl-alkyl-thioxanthenes
#15
JOURNAL ARTICLE
Hakan Deniz, Tülay Yıldız, Hatice Başpınar Küçük
In this study, a series of halogen-substituted thioxanthenes were synthesized because the most important and biologically active derivatives of xanthenes are thioxanthenes. In order to obtain new thioxanthene derivatives, first, the starting molecules were synthesized by the appropriate reaction methods in two steps. The intramolecular Friedel-Crafts alkylation (FCA) method was used to convert the prepared three aromatic substituted starting alcohol compounds to their corresponding thioxanthenes by cyclization...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38524086/kratom-induced-psychiatric-decompensation-and-paranoid-delusions
#16
Matthew Awad, Hugh H Burke, Scott A Oakman
Kratom is a plant extract readily available for purchase in the USA. It is known to produce both stimulant and opioid-related effects, predisposing it to abuse. The long-term effects of kratom are poorly understood. In rare cases, serious side effects have been reported. Here, we report a case of a patient with a history of bipolar type schizoaffective disorder presenting with acute onset paranoia and delusions. The patient had been hospitalized seven times previously with psychotic symptoms, with no reported history of paranoid delusional thought content in previous admissions...
February 2024: Curēus
https://read.qxmd.com/read/38523764/bell-s-mania-as-a-clinical-presentation-in-a-neurosurgical-setting-from-a-tertiary-care-neuropsychiatric-hospital-in-india
#17
JOURNAL ARTICLE
Harkishan Mamtani, Shridhar Utagi, Kavish K Chaurasia, Preethi Veerappa Reddy, Rashmi Arasappa, Chandrajit Prasad, Dwarakanath Srinivas, Malla Bhaskara Rao, Harish Thippeswamy
Bell's mania is the co-occurrence of delirium and mania. We present two cases of Bell's mania in a neurosurgical setting. The first case is of a 52-year-old male who presented with holocranial headache, disorientation, and manic symptoms for five months. He was found to have suprasellar craniopharyngioma. He significantly improved with olanzapine, but re-emergence of mood symptoms was noted after surgery. The second case is of a 42-year-old male who presented with a 15-day history of seizures and disorientation...
February 2024: Indian Journal of Psychiatry
https://read.qxmd.com/read/38523757/a-summer-of-acute-and-transient-psychosis-a-case-series
#18
JOURNAL ARTICLE
Arohi Vardhan, Rashmi Vishwanath, Savitha Soman, Anil Kumar Nagaraj
The association between the season and the occurrence of acute transient psychotic disorder (ATPD) has been sparsely studied. We would like to report five patients who presented with acute psychotic symptoms during the summer and discuss other risk factors that could be associated with this seasonal predilection.
February 2024: Indian Journal of Psychiatry
https://read.qxmd.com/read/38523205/clinical-features-of-adult-patients-with-positive-nmdar-igg-coexisting-with-mog-igg
#19
JOURNAL ARTICLE
Yuwei Dai, Yu Yuan, Fangfang Bi, Li Feng, Jing Li, Kai Hu, Si Chen, Qing Huang, Juan Li, Lili Long, Bo Xiao, Yuanyuan Xie, Yanmin Song
INTRODUCTION: This study was designed to analyze clinical and radiographic features of adult patients coexisting with NMDAR-IgG and MOG-IgG. METHODS: Eleven adult patients coexisting with NMDAR-IgG and MOG-IgG were collected from Xiangya Hospital, Central South University, between June 2017 and December 2021. Fifty-five patients with anti-NMDAR encephalitis and 49 with MOG-AD were served as controls. RESULTS: Onset age was 27 (IQR 20-34) years old...
March 25, 2024: Neurological Sciences
https://read.qxmd.com/read/38522509/antenatal-psychiatric-hospitalization-factors-associated-with-newborns-custody-under-child-protective-services-cps
#20
JOURNAL ARTICLE
Tyler Torrico, Emily Fitzsimmons, Shrey Patel, Juan Lopez, Ranjit Padhy, Muhammad T Salam, Sara Abdijadid
BACKGROUND: Psychiatric illness during pregnancy is associated with adverse obstetric outcomes, but investigations for its impact on parenting capacity are limited. Child Protective Services (CPS) contact disproportionately impacts families marginalized by poverty, mental health disorders, and substance use disorders. Recently, there have been investigations into the significance of psychiatric illness and non-mental health-related factors that predict CPS custody arrangements. METHODS: We conducted a retrospective review of electronic medical records over a 10-year period (2012-2021) for patients who were pregnant during their inpatient psychiatric hospitalizations...
March 22, 2024: Journal of the Academy of Consultation—Liaison Psychiatry
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