Claire Grosu, Paul Klauser, Daniella Dwir, Ines Khadimallah, Yasser Alemán-Gómez, Nermine Laaboub, Marianna Piras, Margot Fournier, Martin Preisig, Philippe Conus, Bogdan Draganski, Chin B Eap
Given the unpredictable rapid onset and ubiquitous consequences of weight gain induced by antipsychotics, there is a pressing need to get insights into the underlying processes at the brain system level that will allow stratification of "at risk" patients. The pathophysiological hypothesis at hand is focused on brain networks governing impulsivity that are modulated by neuro-inflammatory processes. To this aim, we investigated brain anatomy and functional connectivity in patients with early psychosis (median age: 23 years, IQR = 21-27) using anthropometric data and magnetic resonance imaging acquired one month to one year after initiation of AP medication...
March 26, 2024: Translational Psychiatry