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https://www.readbyqxmd.com/read/29305703/cardiac-ischemia-insights-from-computational-models
#1
REVIEW
Axel Loewe, Eike Moritz Wülfers, Gunnar Seemann
BACKGROUND: Complementary to clinical and experimental studies, computational cardiac modeling serves to obtain a comprehensive understanding of the cardiovascular system in order to analyze dysfunction, evaluate existing, and develop novel treatment strategies. OBJECTIVES: We describe the basics of multiscale computational modeling of cardiac electrophysiology from the molecular ion channel to the whole body scale. By modeling cardiac ischemia, we illustrate how in silico experiments can contribute to our understanding of how the pathophysiological mechanisms translate into changes observed in diagnostic tools such as the electrocardiogram (ECG)...
January 5, 2018: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/29296058/myocardial-perfusion-abnormalities-in-asymptomatic-type-2-diabetic-patients
#2
Ghada Al-Humaidi, Ismet Sarikaya, Abdelhamid H Elgazzar, Azu Owunwanne
Objective: The prevalence of coronary artery disease (CAD) is high in patients with diabetes. Because ischemia and infarction are often silent in diabetic patients, diagnosis of CAD occurs inevitably late. It is essential to identify the presence of CAD in diabetic patients to start early treatment. Therefore, the aim of this study was to determine the prevalence of abnormal myocardial perfusion in asymptomatic type 2 diabetic patients using myocardial perfusion imaging. Methods: Fifty-nine patients with type 2 diabetes, who did not have any history of CAD, but did have risk factors underwent myocardial perfusion single-photon emission computed tomography (SPECT) imaging using 99mTc-tetrofosmin and a 2-day stress-rest protocol...
January 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29220696/cardioprotection-of-cape-ono2-against-myocardial-ischemia-reperfusion-induced-ros-generation-via-regulating-the-sirt1-enos-nf-%C3%AE%C2%BAb-pathway-in-vivo-and-in-vitro
#3
Dejuan Li, Xiaoling Wang, Qin Huang, Sai Li, You Zhou, Zhubo Li
Caffeic acid phenethyl ester (CAPE) could ameliorate myocardial ischemia/reperfusion injury (MIRI) by various mechanisms, but there hadn't been any reports on that CAPE could regulate silent information regulator 1 (SIRT1) and endothelial nitric oxide synthase (eNOS) to exert cardioprotective effect. The present study aimed to investigate the cardioprotective potential of caffeic acid o-nitro phenethyl ester (CAPE-oNO2) on MIRI and the possible mechanism based on the positive control of CAPE. The SD rats were subjected to left coronary artery ischemia /reperfusion (IR) and the H9c2 cell cultured in hypoxia/reoxygenation (HR) to induce the MIRI model...
November 29, 2017: Redox Biology
https://www.readbyqxmd.com/read/29205487/the-impact-of-unfractionated-heparin-or-bivalirudin-on-patients-with-stable-coronary-artery-disease-undergoing-percutaneous-coronary-intervention
#4
Fabio V Lima, Luis Gruberg, Usman Aslam, Melissa Ramgadoo, Kydanis Clase, Alessandra Trevisan, Allen Jeremias
OBJECTIVES: To compare bleeding and clinical events of patients with stable angina or silent ischemia undergoing percutaneous coronary intervention (PCI) treated with unfractionated heparin (UFH) or bivalirudin. BACKGROUND: Few direct comparisons between UFH monotherapy versus bivalirudin exist for patients with stable ischemic heart disease undergoing PCI. METHODS: A prospective, investigator-initiated, single-center, single-blinded, randomized trial of UFH versus bivalirudin was conducted...
December 4, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29199266/diagnosis-and-management-of-spontaneously-recanalized-coronary-thrombus-guided-by-optical-coherence-tomography%C3%A3-lessons-from-the-french-lotus-root-registry
#5
Géraud Souteyrand, Mathieu Valladier, Nicolas Amabile, François Derimay, Brahim Harbaoui, Pierre Leddet, Pierre Barnay, Guilhem Malcles, Aurelien Mulliez, Colin Berry, Romain Eschalier, Nicolas Combaret, Pascal Motreff
BACKGROUND: Spontaneous reanalyzed coronary thrombus (SRCT) has been reported in autopsy series, but little is known about SRCT, and it is potentially under-diagnosed in clinical practice.Methods and Results:SRCT identified on OCT were included in a French multicenter series, the Lotus Root French Registry. A total of 34 SRCT were identified on OCT in 33 patients (23 male; median age, 56 years; IQR, 52-65 years); 23/33 patients (70%) presented with angina pectoris and/or dyspnea. Three angiographic aspects were distinguished retrospectively: braided, pseudo-dissected, and hazy...
December 1, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29188156/hypoglycemia-associated-in-stent-thrombosis-are-we-doing-too-much
#6
Uyanga Batnyam, Nway Ko Ko, Aamir Javaid
Diabetes mellitus is one of the most common modifiable risk factors for coronary artery disease, and its prevalence is rising globally. Persistent hyperglycemia has a well-established cardiovascular risk, and its treatment plays an important role in the prevention of future cardiovascular events. While we improved microvascular complications such as retinopathy, nephropathy, and neuropathy by stringent blood glucose control, the cardiovascular morbidity and mortality in diabetics remain high. Hypoglycemia, on the other hand, is an important side effect of pharmaceutical blood glucose control, especially those who are treated with insulin...
September 25, 2017: Curēus
https://www.readbyqxmd.com/read/29175663/changes-in-neurofilament-200-and-tyrosine-hydroxylase-expression-in-the-cardiac-innervation-of-diabetic-rats-during-aging
#7
Marija Bakovic, Natalija Filipovic, Lejla Ferhatovic Hamzic, Nenad Kunac, Elena Zdrilic, Marija Vitlov Uljevic, Sandra Kostic, Livia Puljak, Katarina Vukojevic
Changes in sensory and sympathetic innervation during diabetes mellitus (DM) can be a predictor of arrhythmias, silent myocardial ischemia, and chronic heart failure, but knowledge about these changes is still unsatisfactory. We analyzed whether prolonged DM induces changes in density of sensory and sympathetic nerve terminals of rat's heart and whether it contributes to cardiomyopathy during aging. DM was induced by i/p injecting 55 mg/kg streptozotocin to male Sprague-Dawley rats, while a control group received a citrate buffer...
November 16, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29173598/mechanisms-clinical-significance-and-prevention-of-cognitive-impairment-in-patients-with-atrial-fibrillation
#8
REVIEW
Lena Rivard, Paul Khairy
Atrial fibrillation (AF) and dementia are major health issues, with growing evidence suggesting a consistent association between AF and all forms of dementia. Although dementia and AF share several risk factors, the association appears to be independent of a history of clinical stroke and other comorbidities such as hypertension, heart failure, and diabetes. Proposed mechanisms linking AF to cognitive decline include altered hemodynamics resulting in cerebral hypoperfusion, inflammation, genetic factors, and silent cerebral ischemia due to subclinical microemboli...
December 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29132619/a-statistical-analysis-based-recommender-model-for-heart-disease-patients
#9
Anam Mustaqeem, Syed Muhammad Anwar, Abdul Rashid Khan, Muhammad Majid
OBJECTIVES: An intelligent information technology based system could have a positive impact on the life-style of patients suffering from chronic diseases by providing useful health recommendations. In this paper, we have proposed a hybrid model that provides disease prediction and medical recommendations to cardiac patients. The first part aims at implementing a prediction model, that can identify the disease of a patient and classify it into one of the four output classes i.e., non-cardiac chest pain, silent ischemia, angina, and myocardial infarction...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29129519/sirt6-protects-against-hepatic-ischemia-reperfusion-injury-by-inhibiting-apoptosis-and-autophagy-related-cell-death
#10
Song Zhang, Shuai Jiang, Haiping Wang, Wencheng Di, Chao Deng, Zhenxiao Jin, Wei Yi, Xiao Xiao, Yongzhan Nie, Yang Yang
Silent information regulator 6 (SIRT6), a class III histone deacetylase, has been revealed to participate in multiple metabolic processes in the liver, and it plays important roles in protecting against ischemia/reperfusion (I/R) injury in multiple organs. In this study, we explored whether SIRT6 is protective against hepatic I/R injury and elucidated the underlying mechanisms. The expression of SIRT6 was significantly decreased during reperfusion compared with the control group. SIRT6-LKO mice exhibited significantly aggravated oxidative stress, mitochondrial dysfunction, inflammatory responses, mitogen-activated protein kinase (MAPK) signaling activation, and apoptosis and autophagy related hepatocyte death compared with control mice...
November 10, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29122140/cardiac-tissue-characterization-and-imaging-in-autoimmune-rheumatic-diseases
#11
REVIEW
Sophie I Mavrogeni, Petros P Sfikakis, Loukia Koutsogeorgopoulou, George Markousis-Mavrogenis, Theodoros Dimitroulas, Genovefa Kolovou, George D Kitas
Inflammation, microvascular and macrovascular ischemia, valvular disease, and fibrosis are the main causes of cardiovascular disease (CVD) in autoimmune rheumatic diseases (ARDs). The silent presentation and the high mortality and/or morbidity of CVD in ARDs necessitate a reliable tool for early diagnosis. Noninvasive cardiovascular imaging, including echocardiography, nuclear imaging, cardiovascular computed tomography (CT), cardiac magnetic resonance (CMR), and hybrid imaging modalities, constitutes the main tool for monitoring of CVD in ARDs...
November 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29112472/clinical-evaluation-of-silent-t1-weighted-mri-and-silent-mr-angiography-of-the-brain
#12
Samantha J Holdsworth, Sarah J Macpherson, Kristen W Yeom, Max Wintermark, Greg Zaharchuk
OBJECTIVE: New MRI sequences based on rapid radial acquisition have reduced gradient noise. The purpose of this study was to compare Silent T1-weighted and unenhanced MR angiography (MRA) against conventional sequences in a clinical population. MATERIALS AND METHODS: The study cohort consisted of 40 patients with suspected brain metastases (median age, 60 years; range, 23-91 years) who underwent T1-weighted contrast-enhanced MRI and 51 patients with suspected vascular lesions or cerebral ischemia (median age, 60 years; range, 16-94 years) who underwent unenhanced intracranial MRA...
November 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29099705/coronary-disease-risk-assessment-in-asymptomatic-patients
#13
S Zeikidze
- to assess the risk of coronary disease in patients with asymptomatic ischemia. The work was based on the results of 185 patients' investigation, aged 35-55, among them 159 men and 26 women. All of them underwent selective coronarography. The patients were distributed according to the coronarography data - the first group consisted of individuals who had any coronary stenosis. The second group consisted of patients with intact coronaries. Statistical analysis was performed using the program packet SPSS v. 22...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29099704/diagnostic-value-of-moderate-dilatation-of-the-left-ventricle-in-asymptomatic-silent-ischemia
#14
S Zeikidze
Goal of the study - defining of diagnostic and prognostic values of the moderate dilatation of the left ventricle in theasymptomatic (Silent) ischemia. The report was based on the investigation results of 185 patients, aged 35-55, who did not have typical stenocardia pain. Out of the given contingent, 117 patients who had the mild and moderate dilatation of the left ventricle were united under the name of moderate dilatation group. Another group of 68 patients, who did not have this pathology, was used as a control group...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29095260/woven-coronary-anomaly-leading-to-silent-myocardial-infarction-a-case-report
#15
Zhenhua Xing, Liang Tang, Jiabing Huang, Xinqun Hu
RATIONALE: Woven coronary artery is an extremely unusual congenital anomaly with unknown etiology. Because of normal flow after anomalous segment, this anomaly is considered to be benign. PATIENT CONCERNS: A 51-year-old man was admitted to our hospital with exertional dyspnea that he had experienced for half a year. Woven coronary artery was found in coronary angiography. DIAGNOSES: The patient was diagnosed with mitral regurgitation and woven coronary...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29041876/-stress-echocardiography-in-the-assessment-of-long-term-outcomes-after-percutaneous-coronary-intervention-in-patients-with-stable-coronary-heart-disease
#16
A Y Karpov, M M Elkanova, N V Shitov, V U Botvina, V V Lopukhova, A M Saidova
AIM: To study the possibilities of stress echocardiography (EchoCG) in the assessment of clinical state of patients after percutaneous coronary intervention (PCI). MATERIAL AND METHODS: We included into this study 80 patients with stable ischemic heart disease. After preliminary examination, all patients underwent PCI. Stress EchoCG was carried out in 6 and 12 months after PCI. RESULTS: Clinical effect assessed in 12 months after revascularization was good in 90% of patients...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29035435/clinical-and-angiographic-outcomes-of-the-first-korean-made-sirolimus-eluting-coronary-stent-with-abluminal-bioresorbable-polymer
#17
Hyoung Mo Yang, Kyoung Woo Seo, Junghan Yoon, Hyo Soo Kim, Kiyuk Chang, Hong Seok Lim, Byoung Joo Choi, So Yeon Choi, Myeong Ho Yoon, Seung Hwan Lee, Sung Gyun Ahn, Young Jin Youn, Jun Won Lee, Bon Kwon Koo, Kyung Woo Park, Han Mo Yang, Jung Kyu Han, Ki Bae Seung, Wook Sung Chung, Pum Joon Kim, Yoon Seok Koh, Hun Jun Park, Seung Jea Tahk
BACKGROUND AND OBJECTIVES: This trial evaluated the safety and efficacy of the Genoss drug-eluting coronary stent. METHODS: This study was a prospective, multicenter, randomized trial with a 1:1 ratio of Genoss drug-eluting stent (DES)™ and Promus Element™. Inclusion criteria were the presence of stable angina, unstable angina, or silent ischemia. Angiographic inclusion criteria were de novo coronary stenotic lesion with diameter stenosis >50%, reference vessel diameter of 2...
September 18, 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29021858/landiolol-suppression-of-electrical-storm-of-torsades-de-pointes-in-patients-with-congenital-long-qt-syndrome-type-2-and-myocardial-ischemia
#18
Ryota Kitajima, Takeshi Aiba, Tsukasa Kamakura, Kohei Ishibashi, Mitsuru Wada, Yuko Inoue, Koji Miyamoto, Hideo Okamura, Takashi Noda, Satoshi Nagase, Yu Kataoka, Yasuhide Asaumi, Teruo Noguchi, Satoshi Yasuda, Kengo Kusano
A 76-year-old man who had been diagnosed with long-QT syndrome type 2 had frequent syncopal attacks. The electrocardiogram was monitored, and frequent torsades de pointes (TdP) was detected despite administration of conventional medications: oral propranolol, verapamil, intravenous magnesium sulfate, verapamil, and lidocaine. In contrast, 2 μg/kg/min landiolol could completely suppress TdP. Subsequently, an implantable cardioverter defibrillator was placed, and he was diagnosed with silent myocardial ischemia using myocardial perfusion scintigraphy and coronary angiography...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29018134/neuronal-sirt1-silent-information-regulator-2-homologue-1-regulates-glycolysis-and-mediates-resveratrol-induced-ischemic-tolerance
#19
Kevin B Koronowski, Nathalie Khoury, Isabel Saul, Zachary B Loris, Charles H Cohan, Holly M Stradecki-Cohan, Kunjan R Dave, Juan I Young, Miguel A Perez-Pinzon
BACKGROUND AND PURPOSE: Resveratrol, at least in part via SIRT1 (silent information regulator 2 homologue 1) activation, protects against cerebral ischemia when administered 2 days before injury. However, it remains unclear if SIRT1 activation must occur, and in which brain cell types, for the induction of neuroprotection. We hypothesized that neuronal SIRT1 is essential for resveratrol-induced ischemic tolerance and sought to characterize the metabolic pathways regulated by neuronal Sirt1 at the cellular level in the brain...
November 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28965081/sirt1-sirt3-axis-regulates-human-blood-brain-barrier-permeability-in-response-to-ischemia
#20
Tao Chen, Shu-Hui Dai, Xia Li, Peng Luo, Jie Zhu, Yu-Hai Wang, Zhou Fei, Xiao-Fan Jiang
Sirtuin1 (Sirt1) and Sirtuin3 (Sirt3) are two well-characterized members of the silent information regulator 2 (Sir2) family of proteins. Both Sirt1 and Sirt3 have been shown to play vital roles in resistance to cellular stress, but the interaction between these two sirtuins has not been fully determined. In this study, we investigated the role of Sirt1-Sirt3 axis in blood-brain barrier (BBB) permeability after ischemia in vitro. Human brain microvascular endothelial cells and astrocytes were co-cultured to model the BBB in vitro and oxygen and glucose deprivation (OGD) was performed to mimic ischemia...
September 22, 2017: Redox Biology
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