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https://www.readbyqxmd.com/read/28241671/the-effect-of-copper-and-selenium-nanocarboxylates-on-biomass-accumulation-and-photosynthetic-energy-transduction-efficiency-of-the-green-algae-chlorella-vulgaris
#1
Natalia F Mykhaylenko, Elena K Zolotareva
Nanoaquachelates, the nanoparticles with the molecules of water and/or carboxylic acids as ligands, are used in many fields of biotechnology. Ultra-pure nanocarboxylates of microelements are the materials of spatial perspective. In the present work, the effects of copper and selenium nanoaquachelates carboxylated with citric acid on biomass accumulation of the green algae Chlorella vulgaris were examined. Besides, the efficiency of the reactions of the light stage of photosynthesis was estimated by measuring chlorophyll a fluorescence...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28241581/crystal-growth-optical-spectroscopy-and-laser-action-of-tm-sup-3-sup-doped-monoclinic-magnesium-tungstate
#2
Lizhen Zhang, Haifeng Lin, Ge Zhang, Xavier Mateos, Josep Maria Serres, Magdalena Aguiló, Francesc Díaz, Uwe Griebner, Valentin Petrov, Yicheng Wang, Pavel Loiko, Elena Vilejshikova, Konstantin Yumashev, Zhoubin Lin, Weidong Chen
We report on the crystal growth, spectroscopic investigation and laser performance of Tm<sup>3+</sup>-doped monoclinic magnesium tungstate (Tm:MgWO<sub>4</sub>), for the first time, to the best of our knowledge. A high-quality crystal has been grown by the top seeded solution growth method. The relevant spectroscopic properties are characterized in terms of absorption, luminescence and Raman spectroscopy. Judd-Ofelt (J-O) analysis is performed to evaluate the spontaneous emission probabilities and the radiative lifetimes...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28241562/lookup-table-based-inverse-model-for-mapping-oxygen-concentration-of-cutaneous-microvessels-using-hyperspectral-imaging
#3
Wei Feng, Rui Shi, Chao Zhang, Tingting Yu, Dan Zhu
Hyperspectral imaging combining with skin optical clearing technique provides a possible way to non-invasively monitor hemodynamics of cutaneous microvessels. In order to estimate microvascular blood oxygen saturation, in this work, a lookup-table-based inverse model was developed to extract the microvascular optical and physiological properties using hyperspectral analysis. This approach showed a higher fitting degree than currently existing hyperspectral analysis methods (i.e. multiple linear regression and non-negative least square fit) in estimating blood oxygen saturation...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28241467/role-of-protein-phosphatase-2a-in-osteoblast-differentiation-and-function
#4
REVIEW
Hirohiko Okamura, Kaya Yoshida, Hiroyuki Morimoto, Jumpei Teramachi, Kazuhiko Ochiai, Tatsuji Haneji, Akihito Yamamoto
The reversible phosphorylation of proteins plays hugely important roles in a variety of cellular processes, such as differentiation, proliferation, and apoptosis. These processes are strictly controlled by protein kinases (phosphorylation) and phosphatases (de-phosphorylation). Here we provide a brief history of the study of protein phosphorylation, including a summary of different types of protein kinases and phosphatases. One of the most physiologically important serine/threonine phosphatases is PP2A. This review provides a description of the phenotypes of various PP2A transgenic mice and further focuses on the known functions of PP2A in bone formation, including its role in osteoblast differentiation and function...
February 23, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28241406/interferon-stimulated-gene-15-in-the-control-of-cellular-responses-to-genotoxic-stress
#5
Young Joo Jeon, Jong Ho Park, Chin Ha Chung
Error-free replication and repair of DNA are pivotal to organisms for faithful transmission of their genetic information. Cells orchestrate complex signaling networks that sense and resolve DNA damage. Post-translational protein modifications by ubiquitin and ubiquitin-like proteins, including SUMO and NEDD8, are critically involved in DNA damage response (DDR) and DNA damage tolerance (DDT). The expression of interferon-stimulated gene 15 (ISG15), the first identified ubiquitin-like protein, has recently been shown to be induced under various DNA damage conditions, such as exposure to UV, camptothecin, and doxorubicin...
February 27, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28241321/t-cell-derived-granulocyte-macrophage-colony-stimulating-factor-contributes-to-dry-eye-disease-pathogenesis-by-promoting-cd11b-myeloid-cell-maturation-and-migration
#6
Thomas H Dohlman, Julia Ding, Reza Dana, Sunil K Chauhan
Purpose: Growing evidence suggests that granulocyte-macrophage colony-stimulating factor (GM-CSF) contributes to T helper 17 (Th17) cell-associated immunoinflammatory diseases. The purpose of this study was to evaluate the effect of T cell-derived GM-CSF on CD11b+ myeloid cell function in dry eye disease (DED). Methods: In a murine model of DED, quantitative real-time PCR and ELISA were used to measure GM-CSF expression at the ocular surface, and flow cytometry was used to enumerate GM-CSF producing Th17 cells...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28241315/development-of-a-chromatic-pupillography-protocol-for-the-first-gene-therapy-trial-in-patients-with-cnga3-linked-achromatopsia
#7
Jolanta Lisowska, Lukasz Lisowski, Carina Kelbsch, Fumiatsu Maeda, Paul Richter, Susanne Kohl, Ditta Zobor, Torsten Strasser, Krunoslav Stingl, Eberhart Zrenner, Tobias Peters, Helmut Wilhelm, M Dominik Fischer, Barbara Wilhelm
Purpose: To establish a feasible and sensitive pupillographic protocol to assess outer and inner retinal function for the first gene therapy trial in achromatopsia patients (ACHM) with mutations in CNGA3. Methods: Twenty-seven CNGA3-ACHM patients and 22 age-matched control subjects were tested using chromatic pupillography. Three different protocols were established to assess the pupillary light reflex parameters and to create the final protocol. In the individual protocols, various stimulus parameters (i...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28241314/retinal-pigment-epithelial-cells-suppress-phagolysosome-activation-in-macrophages
#8
Eric Wang, Yoona Choe, Tat Fong Ng, Andrew W Taylor
Purpose: The eye is an immune-privileged microenvironment that has adapted several mechanisms of immune regulation to prevent inflammation. One of these potential mechanisms is retinal pigment epithelial cells (RPE) altering phagocytosis in macrophages. Methods: The conditioned media of RPE eyecups from eyes of healthy mice and mice with experimental autoimmune uveitis (EAU) were used to treat primary macrophage phagocytizing pHrodo bacterial bioparticles. In addition, the neuropeptides were depleted from the conditioned media of healthy RPE eyecups and used to treat phagocytizing macrophages...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28241310/editing-vegfr2-blocks-vegf-induced-activation-of-akt-and-tube-formation
#9
Xionggao Huang, Guohong Zhou, Wenyi Wu, Gaoen Ma, Patricia A D'Amore, Shizuo Mukai, Hetian Lei
Purpose: Vascular endothelial growth factor receptor 2 (VEGFR2) plays a key role in VEGF-induced angiogenesis. The goal of this project was to test the hypothesis that editing genomic VEGFR2 loci using the technology of clustered regularly interspaced palindromic repeats (CRISPR)-associated DNA endonuclease (Cas)9 in Streptococcus pyogenes (SpCas9) was able to block VEGF-induced activation of Akt and tube formation. Methods: Four 20 nucleotides for synthesizing single-guide RNAs based on human genomic VEGFR2 exon 3 loci were selected and cloned into a lentiCRISPR v2 vector, respectively...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28241158/electronic-dura-mater-meddling-in-the-central-nervous-system
#10
Jocelyne Bloch, Stéphanie P Lacour, Grégoire Courtine
Importance: A growing number of neurologic treatments rely on neural implants capable of delivering electrical and chemical stimulation to targeted regions of the central nervous system for extended periods. Objective: To assess the potential of a novel class of multimodal neural implants, termed electronic dura mater or e-dura, to fulfill this need. Evidence Review: Results from preclinical applications of e-dura implants and clinical evidence...
February 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28241105/rosemary-extract-mediated-lifespan-extension-and-attenuated-oxidative-damage-in-drosophila-melanogaster-fed-on-high-fat-diet
#11
Hua-Li Wang, Zhen-Ou Sun, Rizwan-Ur Rehman, Hong Wang, Yi-Fei Wang, Hao Wang
Rosemary extract has a potent antioxidant activity and is widely used in the food industry. In this study, the lifespan prolonging and antioxidant activity of rosemary extract was evaluated by high-fat-induced oxidative damage in Drosophila melanogaster. The results revealed that the lifespan and climbing ability of fruit flies was enhanced significantly by feeding rosemary extract. Furthermore, feeding with rosemary extract significantly increased the enzyme activity of superoxide dismutase (SOD) and catalase (CAT), and significantly decreased the level of malonaldehyde...
February 27, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28241093/phase-1-2-study-of-immunotherapy-with-dendritic-cells-pulsed-with-autologous-tumor-lysate-in-patients-with-refractory-bone-and-soft-tissue-sarcoma
#12
Shinji Miwa, Hideji Nishida, Yoshikazu Tanzawa, Akihiko Takeuchi, Katsuhiro Hayashi, Norio Yamamoto, Eishiro Mizukoshi, Yasunari Nakamoto, Shuichi Kaneko, Hiroyuki Tsuchiya
BACKGROUND: There are limited options for the curative treatment of refractory bone and soft tissue sarcomas. The purpose of this phase 1/2 study was to assess the immunological and clinical effects of dendritic cells (DCs) pulsed with autologous tumor lysate (TL) in patients with advanced bone and soft tissue sarcomas. METHODS: Thirty-seven patients with metastatic or recurrent sarcomas were enrolled in this study. Peripheral blood mononuclear cells obtained from the patients were suspended in media containing interleukin 4 (IL-4) and granulocyte-macrophage colony-stimulating factor...
February 27, 2017: Cancer
https://www.readbyqxmd.com/read/28241047/hippocampal-ca3-activation-alleviates-fmri-bold-responses-in-the-rat-prefrontal-cortex-induced-by-electrical-vta-stimulation
#13
Thomas Scherf, Frank Angenstein
Functional magnetic resonance imaging (fMRI) was used to identify brain- wide networks that are activated by electrical stimulation of either the ventral tegmental area (VTA) or hippocampal CA3 region. Stimulation of either one of these regions caused significant BOLD responses in common structures, such as the septum and left and right hippocampus, but also in unique structures, such as the medial prefrontal cortex region/anterior cingulum region (mPFC/ACC) and striatum, which were only activated during VTA stimulation...
2017: PloS One
https://www.readbyqxmd.com/read/28241036/analysis-of-mycobacterium-ulcerans-specific-t-cell-cytokines-for-diagnosis-of-buruli-ulcer-disease-and-as-potential-indicator-for-disease-progression
#14
Norman Nausch, Daniel Antwi-Berko, Yusif Mubarik, Kabiru Mohammed Abass, Wellington Owusu, Ellis Owusu-Dabo, Linda Batsa Debrah, Alexander Yaw Debrah, Marc Jacobsen, Richard O Phillips
BACKGROUND: Buruli ulcer disease (BUD), caused by Mycobacterium (M.) ulcerans, is the third most common mycobacterial disease after tuberculosis and leprosy. BUD causes necrotic skin lesions and is a significant problem for health care in the affected countries. As for other mycobacterial infections, T cell mediated immune responses are important for protection and recovery during treatment, but detailed studies investigating these immune responses in BUD patients are scarce. In this study, we aimed to characterise M...
February 27, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28241017/egf-mediated-egfr-erk-signaling-pathway-promotes-germinative-cell-proliferation-in-echinococcus-multilocularis-that-contributes-to-larval-growth-and-development
#15
Zhe Cheng, Fan Liu, Xiu Li, Mengya Dai, Jianjian Wu, Xinrui Guo, Huimin Tian, Zhijie Heng, Ying Lu, Xiaoli Chai, Yanhai Wang
BACKGROUND: Larvae of the tapeworm E. multilocularis cause alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans. A population of stem cell-like cells, the germinative cells, is considered to drive the larval growth and development within the host. The molecular mechanisms controlling the behavior of germinative cells are largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: Using in vitro cultivation systems we show here that the EGFR/ERK signaling in the parasite can promote germinative cell proliferation in response to addition of human EGF, resulting in stimulated growth and development of the metacestode larvae...
February 27, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28240982/inner-ear-excitation-in-normal-and-postmastoidectomy-participants-by-fluid-stimulation-in-the-absence-of-air-and-bone-conduction-mechanisms
#16
Ofri Ronen, Miriam Geal-Dor, Michal Kaufmann-Yehezkely, Ronen Perez, Shai Chordekar, Cahtia Adelman, Haim Sohmer
BACKGROUND: Hearing can be induced not only by airborne sounds (air conduction [AC]) and by the induction of skull vibrations by a bone vibrator (osseous bone conduction [BC]), but also by inducing vibrations of the soft tissues of the head, neck, and thorax. This hearing mode is called soft tissue conduction (STC) or nonosseous BC. PURPOSE: This study was designed to gain insight into the mechanism of STC auditory stimulation. RESEARCH DESIGN: Fluid was applied to the external auditory canal in normal participants and to the mastoidectomy common cavity in post-radical mastoidectomy patients...
February 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28240980/potential-benefits-of-an-integrated-electric-acoustic-sound-processor-with-children-a-preliminary-report
#17
Jace Wolfe, Sara Neumann, Erin Schafer, Megan Marsh, Mark Wood, R Stanley Baker
BACKGROUND: A number of published studies have demonstrated the benefits of electric-acoustic stimulation (EAS) over conventional electric stimulation for adults with functional low-frequency acoustic hearing and severe-to-profound high-frequency hearing loss. These benefits potentially include better speech recognition in quiet and in noise, better localization, improvements in sound quality, better music appreciation and aptitude, and better pitch recognition. There is, however, a paucity of published reports describing the potential benefits and limitations of EAS for children with functional low-frequency acoustic hearing and severe-to-profound high-frequency hearing loss...
February 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28240822/reduced-skeletal-muscle-secreted-frizzled-related-protein-3-is-associated-with-inflammation-and-insulin-resistance
#18
Alok S Pachori, Meenu Madan, Yury O Nunez Lopez, Fanchao Yi, Christian Meyer, Attila A Seyhan
OBJECTIVE: To investigate the role of secreted frizzled-related protein 3 (Sfrp3) in insulin sensitivity (ISi) and β-cell function in humans across a spectrum of glucose homeostasis. METHODS: Subjects included those with normal glucose homeostasis (NGT; n = 18), prediabetes (PD; n = 11), or type 2 diabetes (T2D; n=12). Serum and skeletal muscle (SkM) Sfrp3 levels were measured by ELISA and qPCR, respectively, and insulin signaling pathway was assessed by Western blot...
February 27, 2017: Obesity
https://www.readbyqxmd.com/read/28240813/fabrication-and-characterization-of-conductive-conjugated-polymer-coated-antheraea-mylitta-silk-fibroin-fibers-for-biomedical-applications
#19
Darshan Gh, Dexu Kong, Julien Gautrot, Shyam Kumar Vootla
Conductive polymers are interesting materials for a number of biological and medical applications requiring electrical stimulation of cells or tissues. Highly conductive polymers (polypyrrole and polyaniline)/Antheraea mylitta silk fibroin coated fibers are fabricated successfully by in situ polymerization without any modification of the native silk fibroin. Coated fibers characterized by scanning electron microscopy confirm the silk fiber surface is covered by conductive polymers. Thermogravimetric analysis reveals preserved thermal stability of silk fiber after coating process...
February 27, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28240809/enzyme-based-logic-gates-and-networks-with-output-signals-analyzed-by-various-methods
#20
Evgeny Katz
The paper overviews various methods for analysis of output signals generated by enzyme-based logic systems. The considered methods include different optical techniques (optical absorbance, fluorescence spectroscopy, surface plasmon resonance), electrochemical techniques (cyclic voltammetry, potentiometry, impedance spectroscopy, conductivity measurements, use of field effect transistor devices, pH measurements), and various mechano-electronic methods (using atomic force microscope, quartz crystal microbalance)...
February 27, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
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