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Vesicoureteral reflux

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https://www.readbyqxmd.com/read/29150195/anatomic-findings-associated-with-epispadias-in-boys-implications-for-surgical-management-and-urinary-continence
#1
M Cendron, P S Cho, M Pennison, I Rosoklija, D A Diamond, J G Borer
INTRODUCTION: Pre-operative physical examination of male epispadias allows for classification of epispadias level as glanular (GE), penile (PE) or penopubic (PPE), and for delineation of anatomic anomalies. The incidence of associated extragenital abnormalities, such as vesicoureteral reflux (VUR), bladder neck (BN) abnormality and abnormal pubic diastasis (PD), and their impact on urinary continence has not yet been systematically studied. OBJECTIVE: The goal of this study was to evaluate whether the more proximal level of epispadias correlated with associated extragenital anatomic anomalies seen on initial imaging or endoscopic evaluation, and whether these pre-operative findings contributed to subsequent surgical management and impacted on achieving urinary continence...
October 26, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29146303/comparison-of-intravesical-cohen-and-extravesical-lich-gregoir-ureteroneocystostomy-in-the-treatment-of-unilateral-primary-vesicoureteric-reflux-in-children
#2
Mesrur Selcuk Silay, Turgay Turan, Yunus Kayalı, İsmail Başıbüyük, Bilal Gunaydin, Turhan Caskurlu, M İhsan Karaman
INTRODUCTION: Various intravesical and extravesical techniques have been described for the surgical correction of vesicoureteral reflux (VUR). Among those techniques Cohen (intra-vesical) and Lich-Gregoir (extra-vesical) are the most commonly used ones. However, there are limited studies that compare those two surgical techniques in the literature. OBJECTIVE: In this study, we aim to compare the outcomes of the open intravesical and extravesical procedures for unilateral primary VUR in children...
October 14, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29142969/elucidation-of-renal-scars-in-children-with%C3%A2-vesicoureteral-reflux-using-contrast-enhanced-ultrasound-a-pilot%C3%A2-study
#3
David S Hains, Harris L Cohen, M Beth McCarville, Ellen E Ellison, Amy Huffman, Stacey Glass, Aslam H Qureshi, Keith R Pierce, Ashlyn L Cahill, Ashley Dixon, Noel Delos Santos
Introduction: Vesicoureteral reflux is a common disorder in children but can result in kidney scarring following acute pyelonephritis. The gold standard diagnostic to detect renal scars in children is (99m)Tc-dimercaptosuccinic acid (DMSA) scintigraphy. DMSA has a number of limitations including radiation exposure, need for sedation, and radiotracer supply shortages. Contrast-enhanced ultrasound (CEUS) is a technique whereby biocompatible microspheres of inert gas are administered i.v...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29140596/florence-robotic-intracorporeal-neobladder-florin-a-new-reconfiguration-strategy-developed-following-the-ideal-guidelines
#4
Andrea Minervini, Davide Vanacore, Gianni Vittori, Martina Milanesi, Agostino Tuccio, Giampaolo Siena, Riccardo Campi, Andrea Mari, Andrea Gavazzi, Marco Carini
OBJECTIVE: To describe our step-by-step technique for robotic intracorporeal neobladder configuration, including the stages of conception, development and exploration of this surgical innovation, according to the IDEAL Collaboration guidelines. PATIENTS AND METHODS: FloRIN neobladder was performed after the following main surgical steps: isolation of 50 cm of ileum; bowel anastomosis; urethro-ileal anastomosis creating an asymmetrical U shape (30 cm distally and 20 cm proximally to anastomosis), ileum detubularisation; posterior wall reconfiguration as an L; bladder neck reconstruction; anterior folding of the posterior plate to reach the 12 o'clock position; uretero-enteral "orthotopic" bilateral anastomosis...
November 15, 2017: BJU International
https://www.readbyqxmd.com/read/29138122/a-novel-mutation-in-trps1-in-a-patient-with-tricho-rhino-phalangeal-syndrome-type-1-accompanied-by-vesicoureteral-reflux
#5
Naoko Morimoto, Akira Shimizu, Kazunori Ohnishi, Yutaka Shimomura
No abstract text is available yet for this article.
November 14, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29135976/loss-of-peri-wolffian-duct-stromal-frs2%C3%AE-expression-in-mice-leads-to-abnormal-ureteric-bud-induction-and-vesicoureteral-reflux
#6
Deepti Narla, Stacey B Slagle, Caitlin M Schaefer, Daniel S Bushnell, Pawan Puri, Carlton M Bates
BackgroundFibroblast growth factor receptor 2 (Fgfr2) deletion from murine peri-Wolffian duct stroma (ST) results in aberrant ureteric bud induction, abnormal ureteral insertion into the bladder, and high rates of vesicoureteral reflux (VUR). It is unclear which receptor docking protein(s) is/are responsible for Fgfr2 actions in these tissues. We investigated whether the docking protein, fibroblast receptor substrate 2α (Frs2α), had a role in peri-Wolffian duct ST similar to Fgfr2.MethodsWe conditionally deleted Frs2α in peri-Wolffian duct ST with a Tbx18cre mouse line (Frs2α(ST-/-))...
December 2017: Pediatric Research
https://www.readbyqxmd.com/read/29133166/determination-of-threshold-value-for-follow-up-of-isolated-antenatal-hydronephrosis-detected-in-the-second-trimester
#7
Ravi de Roo, Bart J Voskamp, C Emily Kleinrouweler, Ben W Mol, Eva Pajkrt, Antonia H M Bouts
INTRODUCTION: Isolated antenatal hydronephrosis (ANH), defined as a dilation of the renal pelvis (≥5 mm), is one of the most common abnormalities detected on prenatal ultrasound. However, established cut-off values for postnatal follow-up differ between countries and are based on little evidence. The current protocol in the Netherlands for follow-up might be too conservative. OBJECTIVE: To assess the applicability of a higher threshold for follow-up of isolated antenatal hydronephrosis (ANH) than the current practice, without the risk of missing significant postnatal urinary tract obstruction...
June 21, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29127964/minimally-invasive-management-for-vesicoureteral-reflux-in-infants-and-young-children
#8
REVIEW
Chung-Kwong Yeung, Sujit K Chowdhary, Biji Sreedhar
Minimally invasive ureteral reimplantation is an attractive and useful tool in the armamentarium for the management of complicated vesicoureteral reflux (VUR). Subureteric dextranomer/hyaluronic acid injection, laparoscopic extravesical ureteric reimplantation and pneumovesicoscopic intravesical ureteral reimplantation with or without robotic assistance are established minimally invasive approaches to management of VUR. The high cost and the limited availability of robotics have restricted accessibility to these approaches...
December 2017: Clinics in Perinatology
https://www.readbyqxmd.com/read/29125525/early-postnatal-bladder-function-in-fetoscopic-myelomeningocele-repair-patients
#9
Gene O Huang, Michael A Belfort, William E Whitehead, Oluyinka O Olutoye, Jonathan Castillo, Heidi Castillo, Kathryn K Ostermaier, Chester J Koh, Duong D Tu
PURPOSE: Prenatal repair of myelomeningocele (MMC) via hysterotomy has demonstrated neurosurgical and motor benefits, when compared to postnatal repairs. Urologic benefits, however, remain to be seen. The purpose of this study was to review early postnatal bladder function in patients undergoing a novel endoscopic approach for MMC repair using an exteriorized uterus. METHODS: A prospective urologic assessment of patients undergoing fetoscopic MMC repair and receiving subsequent care at our facility, was performed...
October 20, 2017: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/29124347/the-effect-of-onabotulinumtoxina-according-to-site-of-injection-in-patients-with-overactive-bladder-a-systematic-review-and-meta-analysis
#10
Jung Ki Jo, Kyu Nam Kim, Dong Won Kim, Yong Tae Kim, Ji Yoon Kim, Ji Yeon Kim
PURPOSE: This study assessed the efficacy and safety of onabotulinumtoxinA according to injection site for treatment of overactive bladder. METHODS: A systematic literature review located randomized controlled trials of onabotulinumtoxinA treatment for neurogenic detrusor overactive bladder and idiopathic overactive bladder in adults. We searched MEDLINE, EMBASE, and the Cochrane Controlled Trials Register using the Ovid platform. Meta-analysis was based on Cochrane Review Methods...
November 9, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29118540/total-endoscopic-and-anal-irrigation-management-approach-to-noncompliant-neuropathic-bladder-and-bowel-in-children-a-long-term-follow-up
#11
Naif Alqarni, Hamdan Alhazmi, Ossamah Alsowayan, Tamer Eweda, Khalid Fouda Neel
Purpose: To evaluate the long-term efficacy and durability of combined intradetrusor botulinum-A toxin (BTX-A), endoscopic treatment of vesicouerteral reflux and anal irrigation for stool incontinence (SI) via a total endoscopic and anal irrigation management (TEAM(®)) approach in patients with myelomeningocele and neuropathic bladder and bowel who did not respond to conservative measures. Materials and Methods: Fourteen myelomeningocele patients with at least 3 years follow-up were included in the study...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29104797/endoscopic-correction-of-vesicoureteral-reflux-in-children-using-polyacrylate-polyalcohol-copolymer-vantris-5-years-of-prospective-follow-up
#12
Stanisław Warchoł, Grażyna Krzemień, Agnieszka Szmigielska, Przemysław Bombiński, Krzysztof Toth, Teresa Dudek-Warchoł
Introduction: The endoscopic correction of vesicoureteral reflux (VUR) in children is a currently well accepted therapy in many pediatric urology centers. Polyacrylate-polyalcohol copolymer (PPC), namely Vantris(®), is one of the tissue-augmenting substances used for endoscopic reflux therapy. The aim of this study was to evaluate the results with PPC in children. Material and methods: From 2012 to 2016, 125 children (73 girls and 52 boys) aged 0.6-17.9 years (mean 4...
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/29097723/genome-wide-linkage-and-association-study-implicates-the-10q26-region-as-a-major-genetic-contributor-to-primary-nonsyndromic-vesicoureteric-reflux
#13
John M Darlow, Rebecca Darlay, Mark G Dobson, Aisling Stewart, Pimphen Charoen, Jennifer Southgate, Simon C Baker, Yaobo Xu, Manuela Hunziker, Heather J Lambert, Andrew J Green, Mauro Santibanez-Koref, John A Sayer, Timothy H J Goodship, Prem Puri, Adrian S Woolf, Rajko B Kenda, David E Barton, Heather J Cordell
Vesicoureteric reflux (VUR) is the commonest urological anomaly in children. Despite treatment improvements, associated renal lesions - congenital dysplasia, acquired scarring or both - are a common cause of childhood hypertension and renal failure. Primary VUR is familial, with transmission rate and sibling risk both approaching 50%, and appears highly genetically heterogeneous. It is often associated with other developmental anomalies of the urinary tract, emphasising its etiology as a disorder of urogenital tract development...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29087113/impact-of-using-an-evidence-based-clinical-guideline-for-the-management-of-primary-vesicoureteral-reflux-in-children
#14
Natalia Álvarez García, Reyes Delgado Alvira, Yurema González Ruiz, Alexander Siles Hinojosa, Rafael Fernández Atuán, Miguel A Rihuete Heras, Marisa Justa Roldán, Jesús Gracia Romero
OBJETIVE: To analyze changes in the therapeutic approach at a tertiary care hospital following the implementation of a clinical guideline for the treatment of primary vesicoureteral reflux (VUR) in children. POPULATION AND METHODS: Retrospective study conducted in a cohort of patients with primary VUR (1989-2015) aged 0-15 years at a tertiary care hospital. The therapeutic approach before and after the development of the clinical guideline (2008) was compared. RESULTS: A total of 297 patients (49...
December 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29079659/novel-insights-into-the-pathogenesis-of-monogenic-congenital-anomalies-of-the-kidney-and-urinary-tract
#15
Amelie T van der Ven, Asaf Vivante, Friedhelm Hildebrandt
Congenital anomalies of the kidneys and urinary tract (CAKUT) comprise a large spectrum of congenital malformations ranging from severe manifestations, such as renal agenesis, to potentially milder conditions, such as vesicoureteral reflux. CAKUT causes approximately 40% of ESRD that manifests within the first three decades of life. Several lines of evidence indicate that CAKUT is often caused by recessive or dominant mutations in single (monogenic) genes. To date, approximately 40 monogenic genes are known to cause CAKUT if mutated, explaining 5%-20% of patients...
October 27, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29073098/modulation-of-apoptotic-response-by-lar-family-phosphatases-ciap1-signaling-during-urinary-tract-morphogenesis
#16
Katherine Stewart, You Chi Tang, Maxwell E R Shafer, Adda-Lee Graham-Paquin, Maxime Bouchard
The elimination of unwanted cells by apoptosis is necessary for tissue morphogenesis. However, the cellular control of morphogenetic apoptosis is poorly understood, notably the modulation of cell sensitivity to apoptotic stimuli. Ureter maturation, the process by which the ureter is displaced to the bladder wall, represents an exquisite example of morphogenetic apoptosis, requiring the receptor protein tyrosine phosphatases (RPTPs): LAR and RPTPσ. Here we show that LAR-RPTPs act through cellular inhibitor of apoptosis protein 1 (cIAP1) to modulate caspase 3,7-mediated ureter maturation...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29063225/preperitoneal-surgical-approach-to-treat-vesicoureteral-anastomotic-leakage-distal-stenosis-or-reflux-after-kidney-transplantation
#17
Tom Darius, Antoine Buemi, Laurent Coubeau, Nada Kanaan, Pierre Goffette, Michel Mourad
BACKGROUND: If endourological approaches are not applicable to treat vesicoureteral anastomotic complications after kidney transplantation, the surgical gold standard in many transplant centers is pyeloureterostomy or ureteroureterostomy using the native ureter. We report an original preperitoneal technique that can be used for vesicoureteral reanastomosis in kidney transplant recipients not eligible for endourological treatment. METHODS: Between January 2011 and December 2015, 18 kidney transplant recipients underwent this new surgical procedure...
October 23, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29039894/ureteral-orifice-involvement-by-urothelial-carcinoma-long-term-oncologic-and-functional-outcomes
#18
Muammer Altok, Ali F Sahin, Mehmet I Gokce, Gokhan R Ekin, Rauf Taner Divrik
PURPOSE: Bladder cancer (BC) may involve the ureteral orifice, and the resection of the orifice has oncological and functional consequences such as development of upper tract urothelial carcinoma (UTUC), vesicoureteral reflux or ureteral stenosis. The aim of this study was to investigate the oncological and functional outcomes of the ureteral orifice resection in BC patients and determine the predictive factors for UTUC development. MATERIALS AND METHODS: A total of 1359 patients diagnosed with BC, between 1992 and 2012, were reviewed retrospectively...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29028084/expression-and-clinical-significance-of-aquaporin-1-and-et-1-in-urine-of-children-with-congenital-hydronephrosis
#19
Y Yu, Y-F Kang, K-S Li, Z-H Chen, L Zhang, H-M Zhang, M Zhang
OBJECTIVE: Congenital hydronephrosis is induced by congenital obstruction of uretero pelvic junction, bladder vesicoureteral reflux, posterior urethral valve, stricture of ureter end and ureterocyst, which is extremely apt to cause end-stage renal failure in children. It becomes significant to explore the expression profile and clinical significance of aquaporin-1 (AQP-1) and ET-1 (endothelin-1) in the urine of children with congenital hydronephrosis. PATIENTS AND METHODS: 80 cases of children with congenital hydronephrosis were selected to be the observation group and another 40 cases of children with other diseases were served as control group...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29019761/contrast-enhanced-voiding-urosonography-for-vesicoureteral-reflux-diagnosis-in-children
#20
Carmina Duran, Viviana P Beltrán, Amàlia González, Carles Gómez, Javier Del Riego
Contrast-enhanced voiding urosonography (ceVUS) is a dynamic imaging technique that makes it possible to study the structure of the urinary tract after the administration of intravesical contrast material. Initially, ceVUS was indicated mainly to study vesicoureteral reflux (VUR); however, since the ability of ceVUS to depict the structure of the urethra was demonstrated in both sexes, ceVUS is now indicated for examination of the entire urinary tract. The main benefit of ceVUS is that it does not use ionizing radiation...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
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