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https://www.readbyqxmd.com/read/28423916/pegfilgrastim-induced-bone-pain-a-review-on-incidence-risk-factors-and-evidence-based-management
#1
Donald C Moore, Annie E Pellegrino
OBJECTIVE: To review the incidence, risk factors, and management of pegfilgrastim-induced bone pain (PIBP). DATA SOURCES: PubMed was searched from 1980 to March 31, 2017, using the terms pegfilgrastim and bone pain. STUDY SELECTION AND DATA EXTRACTION: English-language, human studies and reviews assessing the incidence, risk factors, and management of PIBP were incorporated. DATA SYNTHESIS: A total of 3 randomized, prospective studies and 2 retrospective studies evaluated pharmacological management of PIBP...
April 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28423474/nasal-obstructive-disorders-impair-health-related-quality-of-life-in-adolescents-with-persistent-allergic-rhinitis-a-real-life-study
#2
Meritxell Valls-Mateus, Franklin Marino-Sanchez, Karen Ruiz-Echevarría, Paulina Cardenas-Escalante, Rosa Jiménez-Feijoo, Jaime Blasco-Lozano, María Teresa Giner-Muñoz, Oliver Haag, Isam Alobid, Ana María Plaza Martin, Joaquim Mullol
BACKGROUND: We previously reported a higher prevalence of nasal obstructive disorders (NOD) in pediatric patients with persistent allergic rhinitis (PER) not responding to medical treatment. The aim of this study was to determine the impact of NOD on quality of life (QoL) in this population. METHODS: Real-life prospective study including 142 patients (41 children, 6-11 yo and 101 adolescents, 12-17 yo) with moderate and severe PER. After two months of medical treatment (intranasal steroids and antihistamines) patients were asked if their symptoms had improved (yes/no) and classified accordingly in R, responders and NR, non-responders...
April 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28421631/subclinical-lower-airways-correlates-of-chronic-allergic-and-non-allergic-rhinitis
#3
Ricardo J Saranz, Alejandro Lozano, Natalia A Lozano, Marina F Ponzio, Álvaro A Cruz
The upper and lower airways behave as a physiological and pathophysiological unit. Subclinical lower airways abnormalities have been described in patients with rhinitis without asthma. These are expressed as bronchial hyperreactivity, abnormalities in lung function and bronchial inflammation, likely as a result of the same phenomenon with systemic inflammatory impact that reaches both the nose and the lungs, which for unknown reasons does not always have a full clinical expression. Patients with rhinitis are at increased risk of developing asthma; therefore most authors suggest a careful clinical evaluation and monitoring of these patients, especially if symptoms related to inflammation in the lower airways are observed...
April 19, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28416070/-intentional-suicide-with-cyclizine
#4
Nikolaj Preus Hatting, Peter Martin Hansen
Cyclizine is an antihistamine with a sedative effect. In Denmark it is an over-the-counter drug, whereas it is a prescription drug in many other countries. It possesses anticholinergic and antiemetic properties, although the exact mechanism of action is unknown. At doses greater than 5 mg/kg potent side effects of anticholinergic character can be expected. This case report is a description of an intentional suicide with a dose greater than 70 mg/kg.
April 3, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28412664/new-model-for-prediction-binary-mixture-of-antihistamine-decongestant-using-artificial-neural-networks-and-least-squares-support-vector-machine-by-spectrophotometry-method
#5
Shirin Mofavvaz, Mahmoud Reza Sohrabi, Alireza Nezamzadeh-Ejhieh
In the present study, artificial neural networks (ANNs) and least squares support vector machines (LS-SVM) as intelligent methods based on absorption spectra in the range of 230-300nm have been used for determination of antihistamine decongestant contents. In the first step, one type of network (feed-forward back-propagation) from the artificial neural network with two different training algorithms, Levenberg-Marquardt (LM) and gradient descent with momentum and adaptive learning rate back-propagation (GDX) algorithm, were employed and their performance was evaluated...
April 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28407984/review-allergic-contact-stomatitis
#6
REVIEW
Liviu Feller, Neil Hamilton Wood, Razia Abdool Gafaar Khammissa, Johan Lemmer
Allergic contact stomatitis (ACS) is an oral mucosal immunoinflammatory disorder variably characterized clinically by erythematous plaques, vesiculation, ulceration, and/or hyperkeratosis and by pain, burning sensation, or itchiness. ACS is brought about by a T cell-mediated, delayed hypersensitivity immune reaction generated by a second or subsequent contact exposure of an allergen with the oral mucosa, in a genetically susceptible, sensitized subject. Lichenoid contact reaction is a variant of ACS brought about by direct contact with the oral mucosa of certain metals in dental restorations...
May 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28407332/transcriptome-analysis-of-severely-active-chronic-spontaneous-urticaria-shows-an-overall-immunological-skin-involvement
#7
A Giménez-Arnau, L Curto-Barredo, L Nonell, E Puigdecanet, J Yelamos, R Gimeno, S Rüberg, L Santamaria-Babi, R M Pujol
BACKGROUND: The knowledge about chronic spontaneous urticaria (CSU) phenotypes is based on its clinical characteristics, associated comorbidities, course of the disease and its response to the available effective drugs. Genotype expression and its further correlation with CSU phenotypes are still unknown. We describe the cutaneous transcriptome of patients suffering a severely active CSU refractory to antihistamine treatment. METHODS: Through the bioinformatic analysis of the whole Human Genome with Oligo Microarrays and Quantitative real-time polymerase chain reaction (qPCR), relevant genes expressed in non-lesional [NLS-CSU] and lesional skin [LS-CSU]) and peripheral blood were identified in 20 patients suffering from severely active CSU and 10 healthy controls (HCs) RESULTS: From 39 genes differentially expressed in NLS-CSU when compared with HCs, 31 (79...
April 13, 2017: Allergy
https://www.readbyqxmd.com/read/28397724/drug-reaction-with-eosinophilia-and-systemic-symptoms-retrospective-analysis-of-104-cases-over-one-decade
#8
Li Wang, Xue-Ling Mei
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, life-threatening disorder caused by drugs. In the present study, we tried to explore the types of DRESS-inducing drugs, incubation period, features of skin rashes, accompanying visceral damage, and effectiveness of glucocorticoid therapy so as to inform clinical practice. METHODS: Patients diagnosed with a drug-induced rash, dermatitis, and DRESS admitted to our hospital from January 2006 to December 2015 were included in the study...
April 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28396898/-allergic-contact-dermatitis-of-the-scalp
#9
REVIEW
L Koch, W Aberer
Contact allergy represents an important differential diagnosis to other skin diseases of the scalp. The typical efflorescences, spreading in the periphery, pruritus, and the clinical history support the differential diagnosis. Since the scalp is particularly resistant to contact dermatitis, allergens applied to this area often produce dermatitis of the eyelids, ears and neck. Nevertheless, potent allergens such as para-phenylendiamine can also cause severe reactions of the scalp. The most important allergens eliciting contact allergy of the scalp are found in bleaches and dyes, shampoos and conditioners, products for perm waves and straighteners as well as topical drugs...
April 10, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28396809/beer-cider-and-wine-allergy
#10
Rhea A Bansal, Susan Tadros, Amolak S Bansal
Background. Allergy to beer is often due to specific proteins in barley and sometimes to lipid transfer protein. Allergy to wine is frequently due to a sensitivity to grape proteins. We present a rare case of allergy to beer, wine, and cider resulting from IgE reactivity to yeasts and moulds which also explained the patient's additional sensitivity to yeast extracts and blue cheese. Case Presentation. The patient's symptoms included throat and facial itching accompanied by mild wheeze and severe urticaria. Diagnosis of allergy to yeast was confirmed by specific IgE testing as well as that to relevant foods and beverages...
2017: Case Reports in Immunology
https://www.readbyqxmd.com/read/28396691/nasal-nitric-oxide-in-allergic-rhinitis-in-children-and-its-relationship-to-severity-and-treatment
#11
Peng-Peng Wang, Gui-Xiang Wang, Wen-Tong Ge, Li-Xing Tang, Jie Zhang, Xin Ni
BACKGROUND: Nasal nitrous oxide (nNO) is increased in allergic rhinitis (AR), but not in asthma, and is a non-invasive marker for inflammation in the nasal passages. METHODS: Levels of nNO were measured and compared in healthy children and children with mild and moderate-to-severe AR. Levels of nNO before and after treatment with steroids and/or antihistamine were then compared in the 2 AR groups. Their relationship to quality of life and nasal symptom and reactivity to outdoor and outdoor allergens were examined...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28391162/quantitative-electrophysiological-monitoring-of-anti-histamine-drug-effects-on-live-cells-via-reusable-sensor-platforms
#12
Viet Anh Pham Ba, Dong-Guk Cho, Daesan Kim, Haneul Yoo, Van-Thao Ta, Seunghun Hong
We demonstrated the quantitative electrophysiological monitoring of histamine and anti-histamine drug effects on live cells via reusable sensor platforms based on carbon nanotube transistors. This method enabled us to monitor the real-time electrophysiological responses of a single HeLa cell to histamine with different concentrations. The measured electrophysiological responses were attributed to the activity of histamine type 1 receptors on a HeLa cell membrane by histamine. Furthermore, the effects of anti-histamine drugs such as cetirizine or chlorphenamine on the electrophysiological activities of HeLa cells were also evaluated quantitatively...
March 31, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28390712/safe-intrathecal-fluorescein-use-for-identification-of-cerebrospinal-fluid-leaks-case-report-and-perioperative-algorithm-description
#13
M Á Rodríguez-Navarro, C Díaz-Alejo, M L Padilla-Del Rey, A B Alcaraz, P González-Pérez, M Benítez
Intrathecal injection of fluorescein is a method for repairing cerebrospinal fluid fistulas. The most frequent surgical procedure is endonasal endoscopy and the purpose of injecting this dye is to locate the fistula. The anaesthesiologists usually perform the puncture, therefore it is necessary to review this method and to specify some anaesthetic considerations such as correct dosing, safe management protocols and medical-legal aspects. In this case-report we describe the pre, intra and postoperative protocol of action implemented in our department that basically consists of: obtaining a specific consent, prior neurological/ophthalmologic assessment to rule out hypertension and brain damage, use of corticosteroids and previous antihistamines, choosing the correct dose and concentration of intrathecal sodium fluorescein (maximum 1ml at a concentration of 5% diluted in 9ml of cerebrospinal fluid) and close intra and postoperative monitoring...
April 5, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28385546/cellular-uptake-of-levocetirizine-by-organic-anion-transporter-4
#14
Saki Noguchi, Tomohiro Nishimura, Saya Mukaida, Leslie Z Benet, Emi Nakashima, Masatoshi Tomi
The pharmacokinetics of cetirizine, a non-sedating antihistamine, is profoundly affected by transporter-mediated membrane transport in the kidney. In this study, we aimed to investigate the transport mechanism of levocetirizine, the pharmacologically active enantiomer of cetirizine, via human organic anion transporter 4 (OAT4) expressed in the apical membrane of renal proximal tubules and the basal plasma membrane of placental syncytiotrophoblasts. In cells expressing human OAT4 under the control of tetracycline, levocetirizine uptake was increased by tetracycline treatment...
April 3, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28381800/citric-acid-suppresses-the-bitter-taste-of-olopatadine-hydrochloride-orally-disintegrating-tablets
#15
Mai Sotoyama, Shinya Uchida, Shimako Tanaka, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Hiroshi Watanabe, Noriyuki Namiki
Orally disintegrating tablets (ODTs) are formulated to disintegrate upon contact with saliva, allowing administration without water. Olopatadine hydrochloride, a second-generation antihistamine, is widely used for treating allergic rhinitis. However, it has a bitter taste; therefore, the development of taste-masked olopatadine ODTs is essential. Some studies have suggested that citric acid could suppress the bitterness of drugs. However, these experiments were performed using solutions, and the taste-masking effect of citric acid on ODTs has not been evaluated using human gustatory sensation tests...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28380487/effectiveness-of-autologous-whole-blood-injections-in-patients-with-refractory-chronic-spontaneous-urticaria
#16
Nikolaos Aggelis Kitsioulis, Paraskevi Xepapadaki, Aggeliki-Victoria Roussaki-Schulze, Nikolaos Papadopoulos, Efterpi Zafiriou
BACKGROUND: Nonsedating antihistamines are the treatment of choice for chronic spontaneous urticaria (CSU), while omalizumab and immunosuppressants have also been approved as an add-on treatment. Autologous whole-blood injection (AWBI) has been used in previous studies with ambiguous results. The aim of our study was to evaluate changes in the Urticaria Activity Score (UAS7), Dermatology Life Quality Index (DLQI), and Chronic Urticaria Quality of Life (CU-Q2oL) score, and also the association of serologic markers with disease severity measures after AWBI...
April 6, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28368217/long-acting-insulin-allergy-in-a-diabetic-child
#17
Carla Mastrorilli, Laura Rizzuti, Antonina Marta Cangelosi, Brunella Iovane, Giovanni Chiari, Carlo Caffarelli
Insulin allergy has been uncommon since the introduction of human recombinant insulin preparations; the prevalence is 2.4%. Insulin injection could elicit immediate reactions, which are usually induced by an IgE-mediated mechanism, within the first hour after drug administration. In the present study, we describe the case of a child who experienced immediate urticaria after long-acting insulin injection. A 9-year-old girl affected by type I diabetes mellitus referred a history of three episodes of urticaria 30 min after insulin subcutaneous injection...
April 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28366479/biologic-therapy-in-the-treatment-of-chronic-skin-disorders
#18
REVIEW
James M Fernandez, Anthony P Fernandez, David M Lang
Understanding of the immunologic pathways involved in the pathogenesis of skin-related diseases is constantly advancing. Several biologic agents play important therapeutic roles for management of patients with chronic urticaria, atopic dermatitis, and psoriasis, particularly omalizumab for antihistamine-resistant chronic urticaria, interleukin (IL)-1 inhibitors for cryopyrin-associated periodic syndrome and Schnitzler syndrome, dupilumab for recalcitrant atopic dermatitis, and IL-17 inhibitors for psoriasis...
May 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/28366435/efficacy-and-safety-of-omalizumab-in-japanese-and-korean-patients-with-refractory-chronic-spontaneous-urticaria
#19
Michihiro Hide, Hae-Sim Park, Atsuyuki Igarashi, Young-Min Ye, Tae-Bum Kim, Akiko Yagami, Jooyoung Roh, Jae-Hyun Lee, Yuko Chinuki, Sang Woong Youn, Soo-Keol Lee, Naoko Inomata, Jeong-Hee Choi, Atsushi Fukunaga, Junyi Wang, Soichiro Matsushima, Steve Greenberg, Sam Khalil
BACKGROUND: Many patients with chronic spontaneous/idiopathic urticaria (CSU/CIU) do not respond adequately to treatment with non-sedating H1 antihistamines (H1AH). There are limited studies on use of omalizumab as add-on therapy for treatment of CSU in an Asian population. OBJECTIVE: The POLARIS study (NCT02329223), representing the first randomized, double-blind, placebo-controlled phase III trial of omalizumab for CSU in an Eastern Asian population, evaluated efficacy and safety of omalizumab as add-on therapy for treatment of CSU...
March 21, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28364659/an-in%C3%A2-vitro-and-in%C3%A2-vivo-evaluation-of-new-potential-trans-sialidase-inhibitors-of-trypanosoma-cruzi-predicted-by-a-computational-drug-repositioning-method
#20
Edgar E Lara-Ramirez, Julio Cesar López-Cedillo, Benjamin Nogueda-Torres, Muhammad Kashif, Carlos Garcia-Perez, Virgilio Bocanegra-Garcia, Rosalía Agusti, María Laura Uhrig, Gildardo Rivera
Chagas disease is one of the most important neglected parasitic diseases afflicting developed and undeveloped countries. There are currently limited options for inexpensive and secure pharmacological treatment. In this study, we employed a structure-based virtual screening protocol for 3180 FDA-approved drugs for repositioning of them as potential trans-sialidase inhibitors. In vitro and in vivo evaluations were performed for the selected drugs against trypomastigotes from the INC-5 and NINOA strains of T...
March 28, 2017: European Journal of Medicinal Chemistry
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