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https://www.readbyqxmd.com/read/29786483/immediate-mild-reactions-to-ct-with-iodinated-contrast-media-strategy-of-contrast-readministration-without-corticosteroids
#1
Sae-Jin Park, Dong-Yoon Kang, Kyoung-Hee Sohn, Soon-Ho Yoon, Whal Lee, Young-Hun Choi, Sang Heon Cho, Hye-Ryun Kang
Purpose To evaluate premedication protocols involving administration of antihistamine and multidose corticosteroid that have been widely used in prevention of recurrent hypersensitivity reactions (HSRs) to iodinated contrast media (ICM); an evidence-based optimal preventive strategy customized for patients with mild cases has not yet been established. Materials and Methods The outcomes of patients with mild HSR who subsequently underwent contrast material-enhanced computed tomography (CT) between January 2012 and December 2015 were analyzed...
May 16, 2018: Radiology
https://www.readbyqxmd.com/read/29782306/urticarial-lesions-in-a-pregnant-woman
#2
Sergio Santos-Alarcón, Cesar Benavente-Villegas, Isabel García-Briz, Magdalena Moneva-Léniz, Celia Sanchis-Sánchez, Almudena Mateu-Puchades
Dear Editor, Gestational pemphigoid (GP) is a rare autoimmune bullous dermatosis in pregnancy. GP usually occurs during the second or third month of pregnancy. It clinically manifests as the development of either early-onset urticarial lesions or late-onset subepidermal blisters that may linger for weeks or even months. Herein we report the case of a 45-year-old woman with the distinctive clinical onset of GP. A forty-five-year-old woman, gravida I, para 0, at 27 weeks gestation, was referred for evaluation to our Department with an extensive pruritic eruption that had developed over the previous 7 days...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29777328/a-systematic-review-on-the-off-label-use-of-montelukast-in-atopic-dermatitis-treatment
#3
Weng Khong Chin, Shaun Wen Huey Lee
Background Atopic dermatitis (AD) is the most common form of eczema. As leukotriene mediators are involved in the inflammatory phase of atopic dermatitis, montelukast has been suggested as a possible therapy. Aim of the review To evaluate the safety and efficacy of montelukast off-label use for the treatment atopic dermatitis. Method A search was performed from database inception until March 2018 in six electronic databases for randomized-controlled-trials examining the use of montelukast for AD. Results Among 301 articles screened, 11 studies met the inclusion criteria and were included in the review...
May 18, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29775497/inflammatory-cytokines-and-peripheral-mediators-in-the-pathophysiology-of-pruritus-in-cutaneous-t-cell-lymphoma
#4
REVIEW
Daniel J Lewis, Simo Huang, Madeleine Duvic
Cutaneous T-cell lymphoma (CTCL) includes a diverse group of neoplasms, including mycosis fungoides and Sézary syndrome. One of the earliest and most common symptoms of CTCL is pruritus, which affects up to 88% of patients. The severity of pruritus can range from mild to very debilitating, producing tremendous discomfort and a significant decrease in quality of life. Patients with advanced disease, in particular, may experience a more chronic, intractable pruritus. However, the underlying mechanism of pruritus in CTCL remains unknown...
May 18, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29775027/-clinical-research-of-different-characteristics-of-fungal-ball-sinusitis
#5
M J Wang, B Zhou, Y C Li, S J Cui, Q Huang
Objective: The aim of this study is to investigate the clinical features of different subtypes of fungal ball sinusitis. Method: Four hundred and forty-nine cases with fungal ball rhinosinusitis (FBS) were involved in this retrospective analysis. The clinical features including symptoms, signs, and imaging scans, pathological results were all collected for each patient and the patients were classified into different subtypes according to these clinical features and the follow-up treatment. Result: In this retrospective study, 449 patients who diagnosed with fungal ball sinusitis were involved...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29772036/chronic-urticaria-following-practice-guidelines
#6
E P Westby, C Lynde, G Sussman
Histamine is a key inflammatory player in the pathogenesis of urticaria, a mast-cell-driven disease characterized clinically by the development of wheals, angioedema, or both. Changes to the management of chronic spontaneous urticaria have recently been adopted due to increasing literature surrounding the efficacy and safety of up-dosing modern second-generation H1 -antihistamines and the use of omalizamub, a biologic agent, as a third-line treatment. Given the prevalence of chronic urticaria and its impact on quality of life, this editorial aims to provide a summary of the proposed updated guidelines for the management of chronic urticaria as agreed upon at the 5th Consensus Conference on the Update and Revision of the EAACI/GA2 LEN/EDF/WAO Guideline for Urticaria in Berlin in December 2016...
May 2018: Skin Therapy Letter
https://www.readbyqxmd.com/read/29770909/omalizumab-in-chronic-spontaneous-urticaria-refractory-to-conventional-therapy-an-italian-retrospective-clinical-analysis-with-suggestions-for-long-term-maintenance-strategies
#7
Victor D Mandel, Mario B Guanti, Serena Liberati, Antongiulio Demonte, Giovanni Pellacani, Patrizia Pepe
INTRODUCTION: Omalizumab is indicated for the treatment of patients affected by chronic spontaneous urticaria (CSU) refractory to antihistamines. The aim of this study was to assess the efficacy, safety, and recurrence of symptoms in a real-life experience of omalizumab as an add-on therapy for H1 -antihistamine-refractory CSU patients (refractory CSU). METHODS: A retrospective review of the clinical records of all refractory CSU treated with omalizumab at our dermatology center from June 2014 to April 2017 was performed...
May 16, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29766368/systemic-contact-dermatitis
#8
REVIEW
Marcella Aquino, Greg Rosner
Systemic contact dermatitis (SCD) traditionally refers to a skin condition where an individual who is cutaneously sensitized to an allergen will subsequently react to that same allergen or a cross reacting allergen via a different route. It occurs to allergens including metals, medications, and foods. The exact pathophysiology underlying this disease remains unknown, although it appears to be mediated by type 4 hypersensitivity reactions and possibly type 3 hypersensitivity reactions. The p-I concept (pharmacologic interaction with immunoreceptors) hypothesized that drugs are able to bind directly to a T cell receptor without first being presented by MHC (major histocompatibility complex) molecules and without prior metabolism, which would help explain why SCD can be seen on first exposure to medications...
May 15, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29760614/eradication-of-helicobacter-pylori-as-add-on-therapy-has-a-significant-but-temporary-influence-on-recovery-in-chronic-idiopathic-urticaria-a-placebo-controlled-double-blind-trial-in-the-polish-population
#9
Robert Pawłowicz, Krzysztof Wytrychowski, Bernard Panaszek
Introduction: The infectious factor like Helicobacter pylori (HP) has been thought to trigger the vicious circle of chronic idiopathic urticaria (CIU), therefore its eradication could modify the course of the disease. Aim: To reveal the influence of HP eradication on CIU clinical course. Material and methods: Sixty-four CIU patients, receiving fexofenadine, as the basic treatment, took part in the research, divided into 3 groups: HP patients treated by eradication, HP patients receiving placebo, and patients without bacteria...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29757034/educational-level-and-job-status-are-the-most-important-factors-affecting-compliance-to-oral-antihistamine-therapy-for-patients-with-chronic-urticaria
#10
Neslihan Akdogan, Pinar Incel-Uysal, Ayşe Oktem, Yildiz Hayran, Basak Yalcin
BACKGROUND: Management of chronic urticaria (CU) is often difficult with oral antihistamines (OAs) despite long-term use. OBJECTIVE: The aim of this study was to determine the extent of medication compliance (MC) and to assess the factors affecting the MC of CU patients toward OA therapy. METHODS: A 43-item questionnaire was administered to 201 adult patients. A compliance score (CS) of 6 points was chosen as a cut-off point. A CS of 0─6 correspond to poor compliance and scores of 6─9, to good compliance...
May 14, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29748453/treatment-strategy-of-allergic-rhinitis-in-the-face-of-modern-world-threats
#11
Piotr Rapiejko, Dariusz Jurkiewicz, Wioletta Pietruszewska, Beata Zielnik-Jurkiewicz, Jarosław Woroń, Agnieszka Lipiec
Allergic rhinitis (AR) is the most common form of allergy, which - as epidemiological research has shown - applies to nearly 25% of the population. AR significantly affects the quality of life of the patient, and the more severe the disease, the greater the risk of developing bronchial asthma. One of the factors affecting the severity of symptoms and the degree of their control is air pollution. In some patients, despite proper treatment, persistence or only partial remission of symptoms (uncontrolled allergic rhinitis) is observed...
April 30, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29748452/influence-of-allergic-rhinitis-in-children-and-adolescents-with-recurrent-headache
#12
Francesco Maria Passali, Maria Carla Spinosi, Giulia Mignacco, Cemal Cingi, Hugo Anibal Rodriguez, Desiderio Passali
INTRODUCTION: Migraine and allergies are a common occurrence. The aim of this study was to investigate the relationship between respiratory allergy and migraine in childhood. MATERIALS AND METHODS: We screened 800 children for headache and its characteristics. After that we investigated the presence of allergy performing prick tests, rhinoscopy, endoscopy, rhinomanometry, cytology and mucociliary clearance tests. RESULTS: Out of 800 children screened, 96 suffered from headache...
April 30, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29744661/update-on-omalizumab-for-urticaria-what-s-new-in-the-literature-from-mechanisms-to-clinic
#13
REVIEW
Désirée E S Larenas-Linnemann, Claudio A S Parisi, Carla Ritchie, Ricardo Cardona-Villa, Ivan Cherrez-Ojeda, Annia Cherrez, Luis Felipe Ensina, Elizabeth Garcia, Iris V Medina, Mónica Rodríguez-González, Jorge Mario Sánchez Caraballo
PURPOSE OF REVIEW: Since omalizumab has been approved for urticaria, numerous randomized and real-life observational trials have been published. We reviewed the period January 2017-February 2018. RECENT FINDINGS: Omalizumab is effective for the control of urticaria recalcitrant to antihistamines in different populations globally. The ratio of total serum IgE 4-week/baseline ≥2 can predict response with a high likelihood. In observational real-life trials, doses have been adjusted on an individual basis: in some populations, up to two-thirds of the patients can be controlled with 150 mg/month; however, others are still not controlled with 300 mg/month...
May 9, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29743774/indolent-systemic-mastocytosis-manifesting-as-protracted-anaphylactic-shock
#14
Manidipam Chatterjee, Saikat Sengupta, Chandrashish Chakravarty, Suresh Ramasubban, Shilpa Bhartia, Sujoy Khan, Vikash Kumar Agarwal
Systemic mastocytosis is a rare disease due to abnormal proliferation of mast cells (MCs). A case of indolent systemic mastocytosis is presented here. After anesthetic induction for elective thyroid swelling with propofol and atracurium followed by endotracheal intubation, a 57-year-old female patient developed acute hypotension, sinus tachycardia, red rashes, increased airway pressure along with difficult ventilation, and desaturation. She developed multiorgan failure subsequently. MC tryptase level was persistently high...
April 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29737920/does-promethazine-shorten-the-length-of-stay-in-the-post-anesthesia-care-unit
#15
Jonathan P Eskander, Yury Rapoport, Elyse Cornett, Sonja Gennuso, Michael Franklin, Alan D Kaye, Charles J Fox
The combination of promethazine and opioids is known to have an opioid-sparing effect, thereby facilitating a reduction in total patient opioid consumption. In recent years, this practice has fallen out of favor in many healthcare facilities, except primarily in the post anesthesia care unit (PACU). The goal of this study was to highlight the potential of promethazine as a direct or indirect adjuvant medication in acute pain management. The present investigation was undertaken with a case series of adult female patients who underwent open total abdominal hysterectomies...
January 1, 2018: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29731560/immunohistochemical-quantification-of-mast-cells-in-inflamed-and-noninflamed-pulp-tissue
#16
G Dinakar, Arathi Ganesh, Ms Prem Kumar, Mythili Sabesan, Malathi Narasimhan, Kandaswamy Deivanayagam
Background: Dental pulp inflammation is a very complex process due to its situation in low compliance (confined environment) surrounded by mineralized dentin. Mast cells are one of the mediators of inflammation. Immunohistochemical localization of mast cells by anti-tryptase antibodies in formalin-fixed paraffin-embedded sections has been shown to be highly specific. The aim of the present study is to quantify the mast cells in inflamed and noninflamed human pulp tissue using immunohistochemical analysis...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29729103/effectiveness-of-omalizumab-in-chronic-spontaneous-urticaria-assessed-with-patient-reported-outcomes-a-prospective-study
#17
Misbah Noshela Ghazanfar, Jesper Grønlund Holm, Simon Francis Thomsen
AIM: To examine the effectiveness of omalizumab (anti-IgE) on symptoms and disease-related quality of life in chronic spontaneous urticaria (CSU), and to identify possible patient specific factors associated with response to omalizumab in patients with antihistamine refractory CSU. METHODS: Six months prospective trial of omalizumab 300 mg every four weeks among patients with CSU from a dermatological university department. The primary outcome was the urticaria activity score in the past week (UAS7) at three months...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29723946/-plantago-psyllium-secondary-anaphylaxis-case-report
#18
Rodrigo Collado-Chagoya, Javier Hernández-Romero, Gumaro Alejandro Eliosa-Alvarado, Ana Carmen García-González, Rosa Isela Campos-Gutiérrez, Andrea Velasco-Medina, Guillermo Velázquez-Sámano
BACKGROUND: Psyllium is a derivative of Plantago ovata ground seed and husk that is used as bulk-forming laxatives owing to its hydrocolloid properties. CASE REPORT: 43-year-old female nurse with previous diagnosis of drug allergy and allergic rhinitis who, after the preparation and administration of a laxative, developed rhinoconjunctivitis symptoms, urticarial syndrome, angioedema and bronchospasm, which led to conclude that she had an anaphylactic reaction. She was treated with adrenaline, corticosteroids and antihistamines...
January 2018: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29723945/-are-natural-analgesic-products-safe-in-patients-with-allergy-to-non-steroidal-anti-inflammatory-drugs
#19
Iván Chérrez-Ojeda, Juan Carlos Calderón, Erick Calero, César Terán, Annia Chérrez
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAID)-induced hypersensitivity reactions can be clinically apparent with asthma, rhinosinusitis, anaphylaxis or rash. Although natural anti-inflammatory products can have similar components, they are not subjected to rigorous quality control standards. CASE REPORT: The case is presented of a 22-year-old female with NSAID allergy who attended with facial and laryngeal angioedema associated with pruritus in eyelids and pharynx...
January 2018: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29723372/suppression-of-wheal-and-flare-in-histamine-test-by-the-main-h1-antihistamines-commercialized-in-brazil
#20
Helena Maciel-Guerra, Mariana Álvares Penha, Marília Formentini Scotton Jorge, Ricardo da Silva Libório, Ana Cláudia Nazareno Dos Anjos Carrijo, Maria Rita Parise-Fortes, Hélio Amante Miot
BACKGROUND: Several dermatoses are mediated by histamine, such as urticaria, angioedema, and papular urticaria. There are no Brazilian studies comparing the potency of antihistamines. OBJECTIVES: To evaluate the tolerability and efficacy of the main commercial brand and generic H1 antihistamines, regarding the suppression of the wheal and flare to the histamine test. METHODS: A quasi-experimental, open study with 10 healthy adults submitted to the histamine test on the ventral aspect of the forearms...
March 2018: Anais Brasileiros de Dermatologia
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