Read by QxMD icon Read


Sahar Z Elazab, Waheed F Hessam
Chronic spontaneous urticaria (CSU) is a common distressing disease caused mainly by autoreactive mechanisms. Autologous serum therapy (AST) has been tried for treatment of many autoimmune diseases including chronic urticaria. We assessed the effect of AST in autologous serum skin test (ASST)-positive and ASST-negative CSU patients. The study included 40 patients clinically diagnosed as CSU. Twenty ASST-positive patients and 20 ASST-negative patients received AST for 8 weeks. Urticarial activity was assessed at baseline, 4th week, 9th week, and at the 12th week by the weekly urticarial activity score (UAS-7) according to the EAACI/GA2LEN/EDF/WAO guidelines...
June 2017: Egyptian Journal of Immunology
Shekhar Neema, Manas Chatterjee
Aim: To study the effects of omalizumab in chronic spontaneous urticaria in Indian patients. Setting and Design: The study was conducted in a tertiary care centre and it was retrospective and descriptive in nature. Material and Methods: We analysed the data of patients who were administered omalizumab between June 2014 and June 2015 for the management of refractory chronic spontaneous urticaria at our centre. Omalizumab was used in those patients who did not respond to updosing of antihistaminics and cyclosporine...
January 2018: Indian Journal of Dermatology
Kiran Godse, Abhishek De, Vijay Zawar, Bela Shah, Mukesh Girdhar, Murlidhar Rajagopalan, D S Krupashankar
This article is developed by the Skin Allergy Research Society of India for an updated evidence-based consensus statement for the management of urticaria, with a special reference to the Indian context. This guideline includes updated definition, causes, classification, and management of urticaria. Urticaria has a profound impact on the quality of life and causes immense distress to patients, necessitating effective treatment. One approach to manage urticaria is by identification and elimination of the underlying cause(s) and/or eliciting trigger(s) while the second one is by treatment for providing symptomatic relief...
January 2018: Indian Journal of Dermatology
Dinesh Puri, Anil Bhandari, Praveen Kumar Gaur, Mohd Yasir, S Sadish Kumar, Deepak Choudhary
OBJECTIVE: The aim of present research work was to develop a herbal fast disintegrating tablet containing Fagonia schweinfurthii Hadidi dried extract and determining its antihistaminic activity using guinea pig ileum. METHOD: The tablets were formulated by wet granulation technique using three different superdisintegrants (croscarmillose, crospovidone and sodium starch glycolate) at three different use levels. The tablets were evaluated for various physical properties like hardness, friability weight variation etc...
March 9, 2018: Current Clinical Pharmacology
(no author information available yet)
BACKGROUND: Chronic idiopathic urticaria (CIU)/spontaneous urticaria (CSU) is defined by the presence of wheals,angioedema, or both for 6 weeks, with or without an identifiable trigger. Real-world health care data among children withCIU/CSU remain scarce. OBJECTIVES: To describe treatment patterns, health care resource utilization (HRU), and costs in pediatric patients with CIU/CSU (12 years old) and to compare these with pediatric patients without CIU/CSU. METHODS: A commercial administrative claims data base (September 2013 to June 2016) was used...
March 7, 2018: Allergy and Asthma Proceedings:
Eustachio Nettis, Luca Cegolon, Elisabetta Di Leo, Walter Giorgio Canonica, Aikaterini Detoraki
BACKGROUND: Omalizumab therapy is effective and safe in patients with chronic spontaneous urticaria (CSU) resistant to nonsedating histamine1 (H1 ) antihistamines (nsAHs). OBJECTIVE: To evaluate the efficacy and safety of omalizumab in elderly (aged ≥65 years) patients with nonsedating H1 -antihistamine-refractory CSU in a real-life setting. METHODS: Patients with nonsedating H1 -antihistamine-refractory CSU (n = 322) treated with omalizumab administered every 4 weeks in doses of 300 mg for 24 weeks were divided into 2 groups according to age at omalizumab treatment onset: 15 to 64 years and 65 years or older...
March 2018: Annals of Allergy, Asthma & Immunology
Anna Domagała, Jacek Szepietowski, Adam Reich
Aim: To evaluate the efficacy of antihistamines in reducing pruritus in psoriasis, 61 patients were randomized to be treated for 1 week with clemastine ( n = 20), levocetirizine ( n = 21) or placebo ( n = 20). Material and methods: All patients received the same routine antipsoriatic treatment. Itch intensity was assessed with VAS and the Itch Questionnaire, and hand movements during sleep were counted with an accelerometer. Results: There was a statistically significant decrease in mean VAS scoring in clemastine and levocetirizine groups ( p < 0...
October 2017: Postȩpy Dermatologii i Alergologii
Ligia Brzezińska-Wcisło, Martyna Zbiciak-Nylec, Dominika Wcisło-Dziadecka, Natalia Salwowska
Treatment during pregnancy is problematic. The Food and Drug Administration established drug categories to help in the treatment process. First-generation antihistamines are considered safe but they have sedative properties. Second-generation antihistamines cause less adverse reactions but besides cetirizine and loratadine they belong to category C. All retinoids should be avoided during pregnancy due to the risk of fetal malformations. Antimalarial drugs should be considered based on the clinical data. Sulfones can be considered as safe for use during pregnancy only with proper monitoring...
October 2017: Postȩpy Dermatologii i Alergologii
Nurdan Bedirli, Berrin Işık, Mehrnoosh Bashiri, Kutluk Pampal, Ömer Kurtipek
RATIONALE: Sugammadex is a cylodextrin derivate that encapsulates steroidal neuromuscular blocker agents and is reported as a safe and well-tolerated drug. In this case report, we present a patient who developed grade 3 anaphylaxis just after sugammadex administration. PATIENT CONCERNS: A 22-year-old woman with diagnosis of Weaver syndrome was scheduled for bilateral mammoplasty and resection of unilateral accessory breast tissue resection. Anesthesia was induced and maintained by propofol, rocuronium, and remifentanil...
January 2018: Medicine (Baltimore)
Jessica Shearer, Pavit Luthra, Alexander C Ford
Objective: Cyclic vomiting syndrome (CVS) is under-recognised. Treatment is difficult as the pathophysiology is incompletely understood. We report our experience of treating patients with amitriptyline, and review the literature to summarise symptoms and associated features, epidemiology, potential pathophysiological mechanisms, differential diagnoses and treatment. Design: Consecutive adult patients with CVS were identified during a 5-year period from January 2010 until December 2015...
January 2018: Frontline Gastroenterology
Lucinda Kennard, Iason Thomas, Krzysztof Rutkowski, Vian Azzu, Patrick Fk Yong, Bogusia Kasternow, Hannah Hunter, Naeema Mo Cabdi, Alla Nakonechna, Annette Wagner
BACKGROUND: Omega-5 gliadin allergy (also known as wheat-dependent exercise induced anaphylaxis) is a rare allergy to wheat which often presents with intermittent severe anaphylaxis in the context of a co-factor, such as exercise. OBJECTIVES: To undertake a detailed clinical characterisation of the largest cohort of omega 5-gliadin allergic patients to date. METHODS: We retrospectively analysed the demographics, presentation, investigation and management of 132 patients presenting to 4 UK centres with omega-5 gliadin allergy...
February 22, 2018: Journal of Allergy and Clinical Immunology in Practice
T A Kanters, H B Thio, L Hakkaart
BACKGROUND: Chronic spontaneous urticaria (CSU) is a skin disease, with itchy hives and / or angioedema that last for at least 6 weeks without an obvious external trigger. OBJECTIVES: The objective of this study was to determine the cost-effectiveness of omalizumab relative to standard of care (SoC; up to 4 times the daily dose of H1-antihistaminics) for the Netherlands from a societal perspective. METHODS: The Markov model used consisted of five health states based on Urticaria Activity Score over seven days (UAS7)...
February 24, 2018: British Journal of Dermatology
Gil Yosipovitch, Sonja Ständer, Matthew B Kerby, James W Larrick, Andrew J Perlman, Edward F Schnipper, Xiaoming Zhang, Jean Y Tang, Thomas Luger, Martin Steinhoff
BACKGROUND: The substance P/neurokinin 1 receptor (NK1 R) pathway is critical in chronic pruritus; anecdotal evidence suggests antagonism of this pathway can reduce chronic itch. OBJECTIVE: To assess the safety and efficacy of the NK1 R antagonist serlopitant in treating chronic pruritus. METHODS: Eligible patients with severe chronic pruritus who were refractory to antihistamines or topical steroids were randomized to serlopitant 0.25, 1, or 5 mg, or placebo, administered once daily for 6 weeks as monotherapy or with midpotency steroids and emollients...
February 17, 2018: Journal of the American Academy of Dermatology
Alice He, Steven R Feldman, Alan B Fleischer
BACKGROUND: Atopic dermatitis (AD) is primarily treated with topical therapies, systemic immunosuppressants, or adjunctive therapies. OBJECTIVE: As novel treatment approaches for AD emerge, we characterize AD treatment and examine trends in treatment over time. METHODS: Visits for AD were identified in the 2003-2012 National Ambulatory Medical Care Survey (NAMCS). We identified topical corticosteroids (TCS), antibiotics (Abx), antihistamines (AH), topical calcineurin inhibitors (TCI), and systemic immunosuppressants (SI) prescribed at AD visits...
February 1, 2018: Journal of Drugs in Dermatology: JDD
A Demonte, M B Guanti, S Liberati, A Biffi, F Fernando, M Fainello, P Pepe
OBJECTIVE: Bilastine is a highly selective, non-sedating antihistamine, indicated for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. Available data suggest that bilastine interferes neither with driving ability nor with flying-related performance. However, no data are available on the effect of bilastine on the driving ability in extreme conditions. Here we analyzed the effect of 7 days treatment with 20 mg bilastine in patients with allergic rhinitis and/or chronic urticaria, on psychophysical performance assessed by the Formula One (F1) high-speed simulator-driving test...
February 2018: European Review for Medical and Pharmacological Sciences
Ying-Xiu Dai, Tzeng-Ji Chen, Yun-Ting Chang
BACKGROUND: Skin diseases are among the most common public health problems and cause a significant burden. For policymakers and clinicians, comprehensive and detailed information is necessary to better allocate resources needed to care for skin diseases. This study was conducted to characterize the ambulatory practice of dermatologists in Taiwan. METHODS: The study data were drawn from the datasets of Taiwan's National Health Insurance Research Database for 2013, with 623,614 records of ambulatory care visits representing 1/500 of all the claims in Taiwan for 2013...
February 16, 2018: Journal of the Chinese Medical Association: JCMA
Serkan Özbilgin, Esra Küpeli Akkol, Burçin Ergene Öz, Mert Ilhan, Gülçin Saltan, Özlem Bahadır Acıkara, Mehmet Tekin, Hikmet Keleş, Ipek Süntar
Objectives: Tanacetum species are traditionally used as insecticide, and externally wound healer as well as for anti-inflammatory and antihistaminic properties. The in vivo wound-healing and anti-inflammatory potential of four Tanacetum species, Tanacetum argenteum (Lam.) Willd. subsp. argenteum (TA) , Tanacetum heterotomum (Bornm.) Grierson (TH), Tanacetum densum (Lab.) Schultz Bip. subsp. sivasicum (TD), and Tanacetum vulgare L. (TV) was investigated. Materials and Methods: The chloroform (CHCl3 ) and methanol:water (80:20) extracts were prepared from the aerial parts of each plant...
February 2018: Iranian Journal of Basic Medical Sciences
Randeep Kaur, V R Sinha
Pruritus is a concomitant symptom of various underlying disorders viz. dermatological, systemic and psychiatric disorders that provoke the person to scratch the skin. Many natural as well as, antipruritic therapies are usually practiced in the treatment of pruritus including general preventive measures, topical therapies such as cooling agents, antihistamines, anesthetics, capsaicin, corticosteroids, immunomodulators and; systemic therapies including administration of antihistamines, opioid antagonists/agonists, antiepileptic drugs/neuroleptics (e...
February 15, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Fabien Milliat, Agnès François
Mast cells are immune cells that mature within the host tissue. The acquired phenotype is dictated by the tissue microenvironment, giving rise to diverse tissue-dependent phenotypes and functions. The lack of cellular models reflecting phenotypes found in vivo and important differences between human and rodent mast cells are obstacles to the understanding of their exact role in several pathophysiological processes. Studies published over the past few years showed that mast cells' role lies far beyond their involvement in allergy and anaphylaxis...
February 2018: Médecine Sciences: M/S
Xin Wang, Sys Stybe Johansen, Marie Katrine Klose Nielsen, Kristian Linnet
Hair can serve as a specimen for identifying past drug exposure. Segmental hair analysis may differentiate a single exposure from chronic use. Consequently, segmental hair analysis is useful for disclosing a single drug ingestion, as well as for determining repeated exposures in drug-facilitated crimes (DFCs). This paper presents an overview of toxicological investigations that have used hair analysis in DFC cases from 2009 to 2016 in Denmark. Hair concentrations were determined for 24 DFC-related drugs and metabolites, including benzodiazepines and other hypnotics, antihistamines, opioid analgesics, antipsychotics, barbiturates, and illicit drugs from DFC cases...
February 5, 2018: Forensic Science International
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"