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https://www.readbyqxmd.com/read/29055251/consistency-of-selected-craniometric-landmark-locations-and-the-resulting-variation-in-measurements
#1
Ashley C Smith, Amelia Boaks
Recently, forensic anthropology has undergone a major shift to quantitative methodologies, including the standardization of osteometric measurements. This study is an analysis of inter-observer error rates for eight "standardized" cranial measurements. Thirty participants, of varied experience, were asked to note the location of landmarks used in each measurement, and to record the resulting measurement. None of the tested measurements met the previously established 80% consensus rate necessary to be considered "standardized-in-practice" [1]...
October 12, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29055085/current-use-of-baseline-medical-treatment-in-chronic-rhinosinusitis-data-from-the-national-chronic-rhinosinusitis-epidemiology-study-cres
#2
Carl Philpott, Sally Erskine, Rupert Smith, Claire Hopkins, Naveed Kara, Amir Farboud, Mahmoud Salam, Alasdair Robertson, Rob Almeyda, B Nirmal Kumar, Shahram Anari, Jaydip Ray, Russell Cathcart, Sean Carrie, Shahzada Ahmed, Hisham Khalil, Allan Clark, Mike Thomas
OBJECTIVES: According to clinical and comissioning guidelines for chronic rhinosinusitis (CRS), patients being referred to secondary care should have failed primary medical treatment with nasal douching (ND) and intranasal corticosteroids (INCS). The study objectives were to identify the rate of specific medical therapy in CRS patients and establish any differences in medication use, for both CRS and associated medical conditions, between CRS phenotypes. DESIGN AND SETTING: Case-control study in a secondary care setting...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29055081/a-new-endoscopic-technique-to-close-big-nasal-septal-perforations-prospective-evaluation-of-the-double-meat-hook-technique-in-19-consecutive-cases
#3
H Dixon, F R Datema
Despite the variety of surgical techniques available to close big symptomatic septum perforations, closure rates of 30 to 70% indicate the difficulty of obtaining a good end result. The double meat hook technique is a new endoscopically assisted technique that delivers excellent visualization and control of mucosal flap elevation, extension and suturing. Mucosa from the nasal floor, lateral nasal wall and inferior turbinate bone are valuable donor site extensions. There is no need for additional incisions into the nasal septal mucosa in order to perform a tension-free closure...
October 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29054909/renal-cell-carcinoma-metastases-to-the-maxillary-sinus
#4
Eugene Hung Chih Wong, Nora Tetter, Katharina Glatz, Yves Brand
Metastasis of renal cell carcinoma (RCC) to the head and neck region is rare. We report the case of a 65-year-old man with history of RCC, presented 7 years after nephrectomy, adrenalectomy and lung metastasectomy for his primary tumour, with symptoms of nasal obstruction, postnasal drip, productive cough and pressure sensation in the left maxillary sinus. CT revealed a unilateral, irregular opacification in the left maxillary sinus with bony erosion of the infraorbital canal wall. A yellow cystic lesion was completely removed from the maxillary sinus during functional endoscopic sinus surgery and histopathological analysis confirmed the diagnosis of a metastatic RCC...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054567/hydrogen-sulfide-specifically-alters-nad-p-h-quinone-dehydrogenase-1-nqo1-olfactory-neurons-in-the-rat
#5
Fumiaki Imamura, Timothy K Cooper, Sanae Hasegawa-Ishii, Takashi Sonobe, Philippe Haouzi
The regions of the olfactory epithelium affected by hydrogen sulfide (H2S) toxicity in the rat present a striking similarity with the developmental olfactory zone 1 described in the mouse. This zone which is the only region containing neurons expressing NAD(P)H quinone dehydrogenase 1 (NQO1) is involved in complex behavioral responses in rodents, and other mammals, triggered by specific olfactory stimuli. We therefore sought to determine whether 1) olfactory neurons expressing NQO1 are located in the same regions in the rats and in the mice and 2) there is an overlap between olfactory neurons expressing this protein and those affected by the toxicity of H2S...
October 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/29054113/post-operative-corticosteroid-irrigation-for-chronic-rhinosinusitis-after-endoscopic-sinus-surgery-a-meta-analysis
#6
Ho Young Yoon, Ho Seok Lee, In Hye Kim, Se Hwan Hwang
BACKGROUND: Recently, topical steroid therapy delivery using high-volume sinonasal irrigations has been used more frequently, following endoscopic sinus surgery (ESS), to improve drug delivery into the paranasal sinuses. OBJECTIVE: The goal of this study was to perform a systematic review with meta-analysis of the efficacy of steroid nasal irrigation on postoperative management of CRS following ESS. METHODS: Five databases (PubMed, SCOPUS, Embase, Web of Science, and the Cochrane database) from inception to March 2017 were independently reviewed by two researchers...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29053938/development-of-a-nanogel-based-nasal-vaccine-as-a-novel-antigen-delivery-system
#7
Rika Nakahashi-Ouchida, Yoshikazu Yuki, Hiroshi Kiyono
Nasal vaccination is one of the most effective immunization methods because it can induce effective antigen-specific immune responses not only at the mucosal site of administration but also at distant mucosal surfaces, as well as in the systemic compartment. Based on this advantage, many nasal vaccines are being developed and some have been licensed and marketed for clinical use. However, some have been withdrawn because of unacceptable adverse events such as inactivated influenza vaccine administrated with a heat-labile enterotoxin of Escherichia coli as an adjuvant...
October 20, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29053911/investigating-the-minimal-clinically-important-difference-for-snot-22-symptom-domains-in-surgically-managed-chronic-rhinosinusitis
#8
Naweed I Chowdhury, Jess C Mace, Todd E Bodner, Jeremiah A Alt, Adam S Deconde, Joshua M Levy, Timothy L Smith
BACKGROUND: Prior work has described 5 domains within the 22-item Sino-Nasal Outcomes Test (SNOT-22) that allow for stratification of symptoms into similar clusters and that can be used to direct therapy. Although the outcomes of various interventions on these symptom domains have been reported, minimal clinically important difference (MCID) values have not been investigated, which has limited clinical interpretation of these results. METHODS: This study was designed as a secondary analysis of a prospective, multi-institutional, observational cohort...
October 20, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29053675/transcanalicular-diode-laser-assisted-dacryocystorhinostomy-for-the-treatment-of-primary-acquired-nasolacrimal-duct-obstruction
#9
Joel M Mor, Yongwei Guo, Konrad R Koch, Ludwig M Heindl
Today's gold standard in the treatment of infrasaccal primary acquired nasolacrimal duct obstruction (PANDO) is external dacryocystorhinostomy (DCR), a relatively invasive procedure that can be performed after failure of recanalizing treatments. However, with progress in the field of diode laser technology, new approaches have emerged. Laser-assisted transcanalicular DCR with subsequent bicanalicular silicon intubation is a new option showing great promise as a viable minimally invasive procedure. Under permanent endoscopic visual control from the nasal cavity, a diode laser fiber is inserted into the lacrimal sac and laser energy is applied to create a bony ostium between the lacrimal sac and the nasal cavity...
October 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053533/use-of-a-single-anatomic-donor-site-for-harvesting-a-full-thickness-skin-graft-and-a-free-cartilage-graft-for-nasal-defects
#10
Jessica Olander, Melanie Wong, Mariah Brown
No abstract text is available yet for this article.
October 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29053517/total-palatal-mobilization-and-multilamellar-suturing-technique-improves-outcome-for-palatal-fistula-repair
#11
Ahmed Elsherbiny, John H Grant
BACKGROUNDS: The success rate of the surgical repair of palatal fistula after palatoplasty is often unsatisfactory. This study is a review of 15 years of single surgeon's experience with the evolution of a reliable surgical technique with high success rate. METHODS: This is a retrospective chart review of consecutive cleft cases undergoing repair of palatal fistula from 2000 to 2015. The study included 37 consecutive fistula repair cases with wide elevation and mobilization of the palatal tissues and nasal and oral layer repair...
October 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29053231/effects-of-common-cold-and-concomitant-administration-of-nasal-decongestant-on-the-pharmacokinetics-and-pharmacodynamics-of-nasal-glucagon-in-otherwise-healthy-participants-a-randomized-clinical-trial
#12
Cristina B Guzman, Helene Dulude, Claude Piché, Marianne Rufiange, Aziz A Sadoune, Emmanouil Rampakakis, Dolores Carballo, Myriam Triest, Michelle Xiaotian Zhang, Shuyu Zhang, Maryam Tafreshi, Eric Sicard
AIMS: Nasal glucagon (NG) is a nasally-administered glucagon powder, absorbed through the nasal mucosa, designed for treatment of severe hypoglycaemia. This study evaluated safety, pharmacokinetics (PK), and pharmacodynamics (PD) of NG in otherwise healthy participants with common colds and after recovery from cold symptoms, with and without concomitant nasal decongestant. MATERIALS AND METHODS: This was a single-centre, open-label study. Cohort 1 participants (N=18) received two NG doses: one while experiencing nasal congestion and another after recovery from cold symptoms...
October 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29053047/perineural-spread-of-basosquamous-carcinoma-to-the-orbit-cavernous-sinus-and-infratemporal-fossa
#13
Alec L Amram, William J Hertzing, Stacy V Smith, Patricia Chévez-Barrios, Andrew G Lee
Basosquamous carcinoma is a rare, highly aggressive variant of basal cell carcinoma with elevated rates of recurrence, perineural invasion, and metastasis. We describe a patient who presented with unilateral complete ophthalmoplegia, ptosis, optic neuropathy, and trigeminal neuropathy due to perineural intracranial invasion of nasal basosquamous carcinoma via the sphenopalatine fossa to the cavernous sinus, orbit, and infratemporal fossa. To our knowledge, this is the first reported case of basosquamous carcinoma with perineural invasion involving the cavernous sinus in the English language ophthalmic literature...
October 20, 2017: Orbit
https://www.readbyqxmd.com/read/29052523/longitudinal-study-of-staphylococcus-aureus-colonization-and-infection-in-a-cohort-of-swine-veterinarians-in-the-united-states
#14
Jisun Sun, My Yang, Srinand Sreevatsan, Jeffrey B Bender, Randall S Singer, Todd P Knutson, Douglas G Marthaler, Peter R Davies
BACKGROUND: People working with pigs are at elevated risk of harboring methicillin resistant S. aureus (MRSA) in their nose, which is attributable to occupational exposure to animals harboring livestock adapted S. aureus. To obtain insight into the biological nature of occupationally related nasal culture positivity, we conducted a longitudinal study of 66 swine veterinarians in the USA. METHODS: The study cohort resided in 15 US states and worked predominantly with swine...
October 19, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29052238/frequent-expression-of-cd30-in-extranodal-nk-t-cell-lymphoma-potential-therapeutic-target-for-anti-cd30-antibody-based-therapy
#15
Keisuke Kawamoto, Hiroaki Miyoshi, Takaharu Suzuki, Yuya Sasaki, Kyohei Yamada, Eriko Yanagida, Reiji Muto, Maiko Kiryu, Hirohito Sone, Masao Seto, Koichi Ohshima, Jun Takizawa
Extranodal NK/T-cell lymphoma, nasal type (ENKTL) is a subtype of non-Hodgkin lymphoma with a poor prognosis. Although first-line treatments for patients with localized ENKTL have been established, there is no gold standard treatment for patients with advanced ENKTL and refractory and/or relapsed disease. Anti-CD30 antibody-based therapy, including brentuximab vedotin (BV), has been shown to target malignant lymphomas with CD30 expression. In particular, this therapeutic agent has recently been suggested to be effective for Hodgkin lymphoma and mature T-cell lymphoma...
October 20, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/29052012/effect-of-nasal-antihistamine-on-secretory-iga-in-nasal-lavage-of-rats
#16
Remzi Doğan, Fadlullah Aksoy, Seda Sezen Goktas, Ilker Kocak, Yavuz Selim Yıldırım, Said Incir, Orhan Özturan
The humoral IgA is an immunoglobulin which plays a defensive role for organisms on mucosal surfaces. Today, intranasal antihistamines are effectively used in the treatment of allergic rhinitis. In our study, the effect of azelastine hydrochloride-a nasal antihistaminic-on humoral IgA of the nasal mucosa has been reviewed empirically. Twenty-four female Sprague-Dawley rats were included in our study. The rats were divided into three groups randomly. Group 1(azelastine hydrochloride): rats in this group had nasal azelastine hydrochloride (0...
October 19, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29051894/a-diagnostic-surprise-primary-hodgkin-s-lymphoma-of-the-lung
#17
Ankur Sinha, Ravikaran Patti, Prabhsimranjot Singh, William Solomon, Yizhak Kupfer
An 81-year-old male presented to the emergency room with a 3-month history of progressive shortness of breath, productive cough with white sputum, and generalized weakness with 10-pound weight loss in 2 months. On presentation, the patient was afebrile, with blood pressure of 93/55 mm Hg and oxy-hemoglobin saturation of 92% on 2 liters of oxygen via nasal cannula. Complete blood count with differential was significant for white count of 12 400/mL. Brain natriuretic peptide level was 454 ng/mL. Postero-anterior chest radiograph showed multiple round opacities in the lung fields...
October 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29051255/complete-genome-sequence-of-porcine-respirovirus-1-strain-usa-mn25890ns-2016-isolated-in-the-united-states
#18
Jie Yeun Park, Michael Welch, Karen M Harmon, Jianqiang Zhang, Pablo E Piñeyro, Ganwu Li, Phillip C Gauger
A porcine parainfluenza virus type 1 (species Porcine respirovirus 1) cell culture isolate, USA/MN25890NS/2016, was obtained from porcine nasal swabs, and its complete genome sequence (GenBank accession number MF681710) was determined to help further characterize this virus.
October 19, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29051065/dihydroergotamine-mesylate-loaded-dissolving-microneedle-patch-made-of-polyvinylpyrrolidone-for-management-of-acute-migraine-therapy
#19
Cetin Tas, Jessica C Joyce, Hiep X Nguyen, Padmanabhan Eangoor, Jennifer S Knaack, Ajay K Banga, Mark R Prausnitz
Migraine is a widespread neurological disease with negative effects on quality of life and productivity. Moderate to severe acute migraine attacks can be treated with dihydroergotamine mesylate (DHE), an ergot derivative that is especially effective in non-responders to triptan derivatives. To overcome limitations of current DHE formulations in subcutaneous injection and nasal spray such as pain, adverse side effects and poor bioavailability, a new approach is needed for DHE delivery enabling painless self-administration, quick onset of action, and high bioavailability...
October 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29050862/jak-stat-signaling-pathway-gene-expression-is-reduced-following-nelf-knockdown-in-gnrh-neurons
#20
Eun Kyung Ko, Lynn P Chorich, Megan E Sullivan, Richard S Cameron, Lawrence C Layman
Hypothalamic gonadotropin releasing hormone (GnRH) is crucial for the proper function of the hypothalamic-pituitary-gonadal (HPG) axis, subsequent puberty, and reproduction. When GnRH neuron migration or GnRH regulation is impaired, hypogonadotropic hypogonadism results. Mutations in the gene for nasal embryonic luteinizing hormone-releasing factor (NELF) have been identified in GnRH-deficient humans. NELF is a predominantly nuclear protein that may participate in gene transcription, but the genes NELF regulates are unknown...
October 16, 2017: Molecular and Cellular Endocrinology
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