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https://www.readbyqxmd.com/read/29684936/the-relationship-between-hard-tissue-and-soft-tissue-dimensions-of-the-nose-in-children-a-3d-cone-beam-computed-tomography-study
#1
Eman Allam, Philani Mpofu, Ahmed Ghoneima, Mihran Tuceryan, Katherine Kula
This study using three-dimensional cone beam computed tomography (CBCT) images of children determined relationships between nasal skeletal and soft tissue measurements and assessed the association with sex, age, and skeletal maturation stage. Following reliability studies, skeletal and soft tissue parameters were measured on coded CBCTs of 73 children (28M:45F;6-13 yoa). Pearson and Mantel correlations were used to analyze associations between skeletal and soft tissues. Partial Mantel correlations were used to study the associations between skeletal and soft tissue, adjusting for sex, age, and skeletal maturation...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684679/comparing-ex-vivo-and-in-vitro-translocation-of-silver-nanoparticles-and-ions-through-human-nasal-epithelium
#2
Jonathan L Falconer, Jeremiah A Alt, David W Grainger
Silver nanomaterials are widely used in clinically approved devices, consumer goods, and over-the-counter nutraceutical products. Despite the increase in silver nanomaterial research, few investigations have specifically distinguished the biological effects resulting from silver nanoparticles (AgNPs) versus silver ions released from AgNPs. This is in part, due to the complex analytical methods required to characterize silver ion release from AgNPs in biological media. This study sought to analyze silver ion release from AgNPs in biological media, compare silver transport from soluble AgNO3 and AgNPs through ex vivo full thickness sinus human tissue explants and human nasal epithelium and determine fractional AgNP internalization by human nasal epithelial cells...
April 14, 2018: Biomaterials
https://www.readbyqxmd.com/read/29684148/antiviral-activity-of-oral-jnj-53718678-in-healthy-adult-volunteers-challenged-with-respiratory-syncytial-virus-a-placebo-controlled-study
#3
Marita Stevens, Sarah Rusch, John DeVincenzo, Young-In Kim, Lisa Harrison, Elizabeth A Meals, Alison Boyers, Juin Fok-Seang, Dymphy Huntjens, Nacer Lounis, Kris Mari N, Bart Remmerie, Dirk Roymans, Anil Koul, René Verloes
Background: Respiratory syncytial virus (RSV) disease has no effective treatment. JNJ-53718678 is a fusion inhibitor with selective activity against RSV. Methods: After confirmation of RSV infection or 5 days post inoculation with RSV, participants (n=69) were randomized to JNJ-53718678 75 mg (n=15), 200 mg (n=17), 500 mg (n=18), or placebo (n=17), orally once-daily for 7 days. Antiviral effects were evaluated by assessing RSV RNA viral load (VL) area-under-the-curve (AUC) from baseline (prior to the first dose) until discharge, time-to-peak VL, duration of viral shedding, clinical symptoms, and quantity of nasal secretions...
April 19, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29683824/a-randomized-trial-comparing-the-effect-of-fiberoptic-selection-and-guidance-versus-random-selection-blind-insertion-and-direct-laryngoscopy-on-the-incidence-and-severity-of-epistaxis-after-nasotracheal-intubation
#4
Jeffrey Leighton Tong, Avery Tung
BACKGROUND: Epistaxis, or nasal bleeding, is a common complication after nasotracheal intubation (NTI). Because such bleeding is likely related to trauma during intubation, use of fiberoptic visualization and guidance rather than direct laryngoscopy may affect the incidence and severity of epistaxis. We compared the incidence of epistaxis after NTI using a fiberoptic versus a direct laryngoscopy approach. METHODS: Seventy patients who were able to breathe easily through unobstructed nostrils and required NTI as part of their anesthetic management were recruited...
April 19, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29683802/a-study-of-familial-char-syndrome-involving-the-tfap2b-gene-with-a-focus-on-facial-shape-characteristics
#5
Daniel Nyboe, Sven Kreiborg, Tron Darvann, Morten Dunø, Kamilla R Nissen, Hanne B Hove
In this case study, we investigate a child presenting with patent ductus arteriosus, short philtrum, duck-bill lips, strabismus, a flat nasal bridge, a broad forehead, low-set ears, hypertelorism, up-slanting palpebral fissures, almond-shaped eyes, and hypodontia, all leading to the clinical diagnosis of Char syndrome. Genetic analysis showed heterozygosity for the novel variant c.851T>C, p. Leu284Ser in the TFAP2B gene. Family analysis suggested that at least 20 members, extending six generations back, were affected...
April 20, 2018: Clinical Dysmorphology
https://www.readbyqxmd.com/read/29683003/assessment-of-a-lateral-nasal-wall-block-technique-for-endoscopic-sinus-surgery-under-local-anesthesia
#6
Grace M Scott, Chris Diamond, Damian C Micomonaco
Introduction With increasingly limited operative resources and patient desires for minimally invasive procedures, there is a trend toward local endoscopic procedures being performed in the outpatient clinic setting. However, there remain limited data supporting a technique to adequately anesthetize the lateral nasal wall and provide patient comfort during these procedures. The objective of this study is to assess the efficacy of a novel lateral nasal wall block for use in office-based endoscopic sinus surgery...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29682983/long-term-clinical-outcomes-of-aspirin-desensitization-with-continuous-daily-aspirin-therapy-in-aspirin-exacerbated-respiratory-disease
#7
Kristen M Walters, Jeremy D Waldram, Katharine M Woessner, Andrew A White
Background Aspirin-exacerbated respiratory disease (AERD), also known as Samter's triad or aspirin (ASA)-intolerant asthma, affects 7% of asthmatics and has a higher prevalence in those with chronic rhinosinusitis and concomitant nasal polyposis. ASA desensitization with daily ASA therapy is a uniquely beneficial treatment for this disease entity and has been shown to have a significant impact on symptom scores, polyp disease, and need for systemic corticosteroids. However, no long-term studies have demonstrated whether or not ASA therapy remains safe and beneficial for these patients beyond 5-10 years...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29682589/parenterally-administered-norovirus-gii-4-virus-like-particle-vaccine-formulated-with-aluminum-hydroxide-or-monophosphoryl-lipid-a-adjuvants-induces-systemic-but-not-mucosal-immune-responses-in-mice
#8
Suvi Heinimäki, Maria Malm, Timo Vesikari, Vesna Blazevic
Norovirus (NoV) is a main cause of acute gastroenteritis across all ages worldwide. NoV vaccine candidates currently in clinical trials are based on noninfectious highly immunogenic virus-like particles (VLPs) delivered intramuscularly (IM). Since NoV is an enteric pathogen, it is likely that mucosal immunity has a significant role in protection from infection in the intestine. Due to the fact that IM delivery of NoV VLPs does not generate mucosal immunity, we investigated whether NoV genotype GII.4 VLPs coadministered with aluminum hydroxide (Al(OH)3 ) or monophosphoryl lipid A (MPLA) would induce mucosal antibodies in mice...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29682532/effect-of-upright-and-slouched-sitting-postures-on-the-respiratory-muscle-strength-in-healthy-young-males
#9
Ali Albarrati, Hamayun Zafar, Ahmad H Alghadir, Shahnwaz Anwer
Objective: The present study compared the effects of upright and slouched sitting postures on the respiratory muscle strength in healthy young males. Methods: A total of 35 adult male subjects aged 18-35 years participated in this study. Respiratory muscle strength was determined by measurement of sniff nasal inspiratory pressure (SNIP) using a MicroRPM device in the upright and slouched sitting positions. The subjects were asked to perform the pulmonary function test including peak expiratory flow (PEF), forced expiratory volume in one second (FEV1 ), forced vital capacity (FVC), and FEV1 /FVC ratio at baseline...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682381/primary-atypical-meningioma-of-the-nasal-cavity-a-case-report-and-review-of-the-literature
#10
Leison Maharjan, Yogesh Neupane, Bibhu Pradhan
Background: Meningioma is a central nervous system tumor that typically arises in proximity to meninges. Extracranial primary atypical meningioma of sinonasal tract is a rare one. Methods: We discuss the clinical, radiological, and histological presentation of an elderly female with primary atypical meningioma of the nasal cavity, which was excised via endoscopic endonasal approach. Results: There was no recurrence even up to 20 months of follow-up after endoscopic excision...
2018: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29682277/the-allergic-rhinitis-clinical-investigator-collaborative-ar-cic-verification-of-nasal-allergen-challenge-procedures-in-a-study-utilizing-an-investigational-immunotherapy-for-cat-allergy
#11
Helen Neighbour, Mena Soliman, Lisa M Steacy, Pascal Hickey, Beth Forbes, Mark Larché, Anne K Ellis
Background: The Allergic Rhinitis Clinical Investigator Collaborative (AR-CIC) is a network of experienced Allergic Rhinitis (AR) researchers developing better research tools based on the nasal allergen challenge (NAC). A key objective of such is the ability to detect efficacy in a small population. AR-CIC sought to test its NAC protocol as a secondary objective in two small mechanistic research trials of a novel form of immunotherapy [Cat Peptide Antigen Desensitisation (Cat-PAD)] for which efficacy had previously been demonstrated...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29682061/transcranial-and-epidural-approach-for-spontaneous-cerebrospinal-fluid-leakage-due-to-meningoencephalocele-of-the-lateral-sphenoid-sinus
#12
Ryosuke Shintoku, Masahiko Tosaka, Tatsuya Shimizu, Yuhei Yoshimoto
We experienced a case of sphenoid sinus type meningoencephalocele manifesting as severe cerebrospinal fluid (CSF) rhinorrhea. A 35-year-old man became aware of serous nasal discharge 1 year previously, which had gradually worsened. The nasal discharge was diagnosed as CSF rhinorrhea. Head computed tomography (CT) showed several small depressions in the bone of the left middle cranial fossa, and the largest depression extended through the bone to the lateral sphenoid sinus. Head magnetic resonance imaging revealed that the meningoencephalocele projected to the lateral sphenoid sinus, through this small bone defect of the middle cranial fossa...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681944/antibacterial-effect-of-hypochlorous-acid-solution-on-nasal-discharge-from-patients-with-chronic-rhinosinusitis
#13
Shang-Heng Wu, Jen-Fu Lin, Rong-San Jiang
Purpose: The antibacterial effect of hypochlorous acid (HOCl) solution on nasal secretion of patients with chronic rhinosinusitis (CRS) was investigated. Materials and Methods: Five swab specimens were collected from the middle meatus of CRS patients. The first one was placed directly in a Thanswab tube while all of the others were placed randomly into 4 glass tubes containing either HOCl solution, normal saline (NS), 75% alcohol, or povidone-iodine (PVPI) solution for one minute in the first part and for 5 minutes in the second part of the study before transfer to a Thanswab tube...
2018: International Journal of Otolaryngology
https://www.readbyqxmd.com/read/29681814/non-gestational-choriocarcinoma-with-widespread-metastases-presenting-with-type-1-respiratory-failure-in-a-39-year-old-female-case-report-and-review-of-the-literature
#14
Louisa Stockton, Elizabeth Green, Baljeet Kaur, Emma De Winton
Introduction: Non-gestational choriocarcinoma (NGCC) is an extremely rare cancer. We report a case presenting in extremis. Case Report: A 39-year-old woman presented with type 1 respiratory failure with a 1-month history of breathlessness. Computed tomography (CT) revealed widespread metastatic disease involving the lungs, liver, pancreas, and breast. Serum β-human chorionic gonadotropin was markedly raised. Over 72 h, she deteriorated and was started on high-flow nasal cannula to facilitate discussions and for comfort...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29681556/structure-and-zonal-expression-of-olfactory-receptors-in-the-olfactory-epithelium-of-the-goat-capra-hircus
#15
Josh Elisha R Octura, Kei-iIchiro Maeda, Yoshihiro Wakabayashi
The mammalian olfactory system employs sophisticated mechanisms to detect and recognize an extensive range of smells. In rodents, the olfactory epithelium (OE), situated within the nasal cavity, mainly comprises four defined endoturbinates and several ectoturbinates. Olfactory receptors (ORs) belong to a large family, comprising over 1,000 genes in rodents, which are expressed in olfactory sensory neurons in the OE that detect odor molecules. The rodent OE is divided into four topographically distinct zones, defined by individual OR distribution...
April 23, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29681466/fibrin-glue-conjunctival-autograft-for-primary-pterygium-overall-outcomes-and-outcomes-in-expert-versus-trainee-ophthalmologists
#16
P Arriola-Villalobos, P Cifuentes-Canorea, J E Peraza-Nieves, J Almendral-Gómez, D Díaz-Valle, C Fernández-Pérez, J M Benítez-Del-Castillo
INTRODUCTION: To determine outcomes of conjunctival autograft attached with fibrin glue (FG) for primary pterygium, and compare these outcomes in expert versus closely supervised trainee ophthalmologists. METHODS: This was a retrospective, comparative, non-randomized, interventional study. Patients were recruited among those with primary nasal pterygium undergoing FG conjunctival autograft. Surgery was performed by expert (136 eyes) or closely supervised trainee (128 eyes) ophthalmologists...
April 19, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29681085/two-novel-cases-expanding-the-phenotype-of-setd2-related-overgrowth-syndrome
#17
Maartje C van Rij, Iris H I M Hollink, Paulien Anna Terhal, Sarina G Kant, Claudia Ruivenkamp, Arie van Haeringen, J Anneke Kievit, Martine J van Belzen
The SETD2-related overgrowth syndrome is also called "Luscan-Lumish syndrome" (OMIM 616831) with the clinical characteristics of intellectual disability, speech delay, macrocephaly, facial dysmorphism, and autism spectrum disorders. We report on two novel patients a 4.5-year-old boy and a 23-year-old female adolescent with a speech and language developmental delay, autism spectrum disorder and macrocephaly, who were both diagnosed with SETD2-related overgrowth syndrome due to de novo frameshift mutations in the SETD2 gene...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29680444/sinonasal-outcome-after-endoscopic-mononostril-transsphenoidal-surgery-a-single-center-cohort-study
#18
Stefan Linsler, Benjamin Prokein, Philipp Hendrix, Joachim Oertel
OBJECTIVE: The endoscopic endonasal approach has been well established for skull base surgery. However, there are only few studies pointing out nasal complaints after surgery. In this study, the authors evaluated postoperative nasal complaints and complications after mononostril endoscopic procedures. METHODS: All patients operated on parasellar and sellar pathologies at our department via an endoscopic mononostril transnasal transsphenoidal approach from January 2011 to May 2015 were analyzed...
April 18, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29680378/characterisation-of-bergeyella-spp-isolated-from-the-nasal-cavities-of-piglets
#19
M Lorenzo de Arriba, S Lopez-Serrano, N Galofre-Mila, V Aragon
The aim of this study was to characterise bacteria in the genus Bergeyella isolated from the nasal passages of healthy piglets. Nasal swabs from 3 to 4 week-old piglets from eight commercial domestic pig farms and one wild boar farm were cultured under aerobic conditions. Twenty-nine Bergeyella spp. isolates were identified by partial 16S rRNA gene sequencing and 11 genotypes were discriminated by enterobacterial repetitive intergenic consensus (ERIC)-PCR. Bergeyella zoohelcum and Bergeyella porcorum were identified within the 11 genotypes...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29679585/personalized-bioactive-nasal-supports-for-postoperative-cleft-rhinoplasty
#20
Christen J Boyer, Jennifer E Woerner, Christopher Galea, Corbin A Gatlin, Ghali E Ghali, David K Mills, Jeffery A Weisman, Jonathan S Alexander
PURPOSE: After cleft lip and palate surgical procedures, patients often need nostril supports to help the reconstructed nostrils retain their shape during healing. Many postoperative nasal stents use a one-size-fits-all approach, in which a standard rubber tube retainer is trimmed and used to support the healing nares. The purpose of this study was to examine photogrammetry and 3-dimensional (3D) printing as a fabrication tool for postoperative patient-specific nasal supports that can be loaded with bioactive agents for localized delivery...
March 28, 2018: Journal of Oral and Maxillofacial Surgery
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