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María Angustias Palomar-Gallego, Francisco Gómez-Esquer, Stella Maris Gómez-Sánchez, Gema Díaz-Gil, Rafael Linares García-Valdecasas
OBJECTIVE: Dermal fillers are an important tool in the field of aesthetic dermatology. Fillers are relatively noninvasive and easy to use but are not free of secondary complications. The main complications are vascular and are due to either the compression of an artery or the direct introduction of the product into the arterial lumen. The aim of this study is to provide an overview of the vascular territories of the face to avoid many possible complications when using facial fillings...
January 16, 2019: Dermatology: International Journal for Clinical and Investigative Dermatology
Alexandre Dufour, Marie Buffier, Delphine Vertu-Ciolino, François Disant, Frédéric Mallein-Gerin, Emeline Perrier-Groult
Nasal reconstruction remains a challenge for every reconstructive surgeon. Alloplastic implants are proposed to repair nasal cartilaginous defects but they are often associated with high rates of extrusion and infection and poor biocompatibility. In this context, a porous polymeric scaffold filled with an autologous cartilage gel would be advantageous. In this study, we evaluated the capacity of IEIK13 self-assembling peptide to serve as support to form such cartilage gel. Human nasal chondrocytes (HNC) were first amplified with FGF-2 and insulin, then re-differentiated in IEIK13 with BMP-2, Insulin and T3 (BIT)...
January 16, 2019: Journal of Biomedical Materials Research. Part A
Samuel Asanad, Jack J Tian, Starleen Frousiakis, Jerry P Jiang, Kaitlin Kogachi, Christian M Felix, Fatemeh Darvizeh, Anne Gority Irvine, Anna Ter-Zakarian, Khalil Ghasemi Falavarjani, Piero Barboni, Rustum Karanjia, Alfredo A Sadun
BACKGROUND: Mitochondrial optic neuropathies such as Leber's Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (DOA) have been shown to produce an optic neuropathy secondary to retinal ganglion cell loss with thinning of the retinal ganglion cell complex (RGCC). METHODS: We performed a retrospective analysis assessing the thicknesses of the peripapillary RNFL (pRNFL) along with the macular RGC-IPL using optical coherence tomography (OCT). We compared these changes among acute and chronic LHON, DOA, and normal healthy control patients...
January 16, 2019: Current Eye Research
Laura J Schmertmann, Alex Kan, Valentina S A Mella, Cristina M Fernandez, Mathew S Crowther, George Madani, Richard Malik, Wieland Meyer, Mark B Krockenberger
Cryptococcosis, caused by environmental fungi in the Cryptococcus neoformans and Cryptococcus gattii species complexes, affects a variety of hosts, including koalas (Phascolarctos cinereus). Cryptococcal antigenemia and nasal colonization are well characterized in captive koalas, but free-ranging populations have not been studied systematically. Free-ranging koalas (181) from the Liverpool Plains region of New South Wales, Australia, were tested for cryptococcal antigenemia (lateral flow immunoassay) and nasal colonization (bird seed agar culture)...
January 12, 2019: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Gregory P DeMuri, Jens C Eickhoff, James C Gern, Ellen R Wald
Background: Acute bacterial sinusitis is a frequent complication of viral upper respiratory infection (URI). We describe clinical and virologic features of URIs that remain uncomplicated and those that precede an episode of sinusitis. We hypothesize that certain viruses are more likely to lead to acute sinusitis and compare viruses identified at time of diagnosis of sinusitis with those identified early in the URI. Methods: Children ages 48-96 months were followed longitudinally for one year...
January 14, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Ashkan Pirayesh, Shaghayegh Shahsavan, Omid Zargari Samani, Hedayatollah Shirzad, Soroush Amani, Mohamad Ali Zamani, Loghman Salimzadeh, Nader Bageri, Mandana Moghni, Fatemeh Deris
BACKGROUND AND AIMS: The roles of Fas in immune system are multifaceted, and the interaction between Fas receptor and Fas ligand is essential for maintaining the immune tolerance. We aimed to assess the level of the expression of Fas receptor on nasal inferior turbinate mucosa in patients with mild persistent allergic rhinitis (M PAR) and moderate to severe (M/S) PAR and determined the relationship between disease severity and production of Fas. METHODS: A total of 70 patients with M/S PAR, 70 patients with M PAR, and 70 healthy individuals were enrolled in this study...
January 16, 2019: American Journal of Rhinology & Allergy
Bhavesh Trikamji, Mark Morrow
Intracranial epidermoid cysts are exceedingly rare lesions that result from a disorder of gastrulation. They are seen only in the pediatric patient population. We describe a 44-year-old Hispanic woman who presented with acute confusion. The family reported two months of progressive headaches and two weeks of fever, blurred central vision, and restricted visual fields. On examination, the patient appeared ill, with a low-grade fever and stiff neck. Neurological testing was limited but grossly non-focal. Computerized tomography (CT) of the head and magnetic resonance imaging (MRI) of the brain showed a large cystic mass arising in the sella, where it displaced the normal pituitary gland...
October 25, 2018: Curēus
Katsuhisa Ikeda, Shin Ito, Remi Hibiya, Hirotomo Homma, Noritsugu Ono, Hiroko Okada, Yoshinobu Kidokoro, Akihito Shiozawa, Takeshi Kusunoki
Introduction  Eosinophilic chronic rhinosinusitis (ECRS) is characterized by an eosinophilic inflammation driven by Th2-type cytokines. Glucocorticosteroids are the most common first-line treatment for ECRS with nasal polyps. Objective  We have evaluated the long-term treatment with double-dose intranasal corticosteroids in refractory ECRS nasal polyps resistant to the conventional dose and assessed the risk of adverse systemic effects Methods  Sixteen subjects were enrolled in this study. All subjects had ECRS after endoscopic sinus surgery that resulted in recurrent mild and moderate nasal polyps and were undergoing a postoperative follow-up application of mometasone furoate at a dose of 2 sprays (100 μg) in each nostril once a day (200 μg)...
January 2019: International Archives of Otorhinolaryngology
Erika Celis-Aguilar, Alan Burgos-Páez, Nadia Villanueva-Ramos, José Solórzano-Barrón, Alma De La Mora-Fernández, Juan Manjarrez-Velázquez, Sergio Verdiales-Lugo, Lucero Escobar-Aispuro, Perla Becerril, Ana Valdez-Flores, Francisco Javier Merino-Ramírez, Carmen Beatriz Caballero-Rodríguez
Introduction  Indolent or chronic mucormycosis is a rare entity that affects both immunosuppressed and immunocompetent individuals. Additionally, its clinical evolution is nonspecific and there is no standardized treatment for this condition. Objective  To describe the clinical characteristics and management of patients with indolent mucormycosis. Methods  In the project of study with chart review in the Interinstitutional secondary care centers, patients with evidence of indolent mucormycosis, defined as pathological confirmation of nasal/paranasal sinus mucormycosis for more than 1 month, were included...
January 2019: International Archives of Otorhinolaryngology
Małgorzata Różańska, Paweł Bielecki, Joanna Reszeć, Krzysztof Kowal, Marek Rogowski
Cysteinyl leukotrienes (CysLTs) have been implicated in the pathogenesis of chronic rhinosinusitis (CRS). This study was undertaken to better understand the role of CysLTs in the development of CRS through 1). assessment of the pattern of expression of CysLT1 receptor in nasal polyps from patients with CRS and 2). correlation of expression of CysLT1 receptor with clinical features. Expression of CysLT1 receptor was evaluated immunohistochemically in nasal polyps from 20 patients with CRS and nasal mucosa from 10 control subject undergoing plastic surgery of the nose...
October 1, 2018: Otolaryngologia Polska
Karl Velik, Youkyung Bae, Robert Allen Fox
While cross-dialectal variations in nasalance have been investigated in previous studies, the influence of regional dialect on listeners' perceptual ratings of nasality has received limited research attention. This study explored cross-dialectal differences in the production of oral-nasal balance and the perception of nasality, with special emphasis on Inland North (IN) and Midland (M) dialects in the USA. Twenty-six adults representing the IN (n = 15) and M (n = 11) dialects participated in the study. Oral-nasal balance characteristics and nasality perception were compared between dialects using mean nasalance of various speech stimuli, measured via nasometry, and perceptual ratings of nasality of synthetic vowel stimuli, measured using direct magnitude estimation (DME)...
January 15, 2019: Clinical Linguistics & Phonetics
Nicolò Maria Vanoni, Manuela Carugati, Noemi Borsa, Giovanni Sotgiu, Laura Saderi, Andrea Gori, Marco Mantero, Stefano Aliberti, Francesco Blasi
Community-acquired pneumonia (CAP) is a leading cause of mortality worldwide. CAP mortality is driven by the development of sepsis and acute respiratory failure (ARF). We performed a systematic review of the available English literature published in the period 1 January 1997 to 31 August 2017 and focused on ARF in CAP. The database searches identified 189 articles-of these, only 29 were retained for data extraction. Of these 29 articles, 12 addressed ARF in CAP without discussing its ventilatory management, while 17 evaluated the ventilatory management of ARF in CAP...
January 14, 2019: Medical Sciences: Open Access Journal
Kim Stobbelaar, Mirjam Kool, Damaris de Kruijf, Kim Van Hoorenbeeck, Philippe Jorens, Jozef De Dooy, Stijn Verhulst
AIM: Bronchiolitis is one of the most common lower respiratory tract infections in young children, associated with significant morbidity, but limited therapeutic options. Nebulised hypertonic saline (HS) has been a supportive treatment until current guidelines advised against its routine use. Accordingly, the University Hospital of Antwerp recently changed their policies to stop using it, allowing us to evaluate retrospectively if HS influences the duration of respiratory support. Because, to our knowledge, the effect of HS on children with severe bronchiolitis admitted to a paediatric intensive care unit (PICU) has not been studied yet, we aimed to investigate the effect in this specific patient group...
January 6, 2019: Journal of Paediatrics and Child Health
Richard G Douglas, Alkis J Psaltis, Joanne Rimmer, Tom Kuruvilla, Anders Cervin, Yina Kuang
BACKGROUND: Chronic rhinosinusitis (CRS) patients who fail medical management have few treatment options other than endoscopic sinus surgery (ESS). A novel biodegradable mometasone furoate drug delivery system (LYR-210) providing continuous topical steroid therapy to sinonasal mucosa over 24 weeks was developed to treat unoperated CRS patients who have failed medical management prior to ESS. LYR-210 was designed to slowly expand in the middle meatus, ensuring efficient drug delivery as mucosal swelling reduces...
January 15, 2019: International Forum of Allergy & Rhinology
Gábor Mohos, Ádám Kocsis, Gábor Erős, Csilla Korponyai, Ákos Varga, Balázs Bende, János Varga
AIM OF THE STUDY: During the reconstruction of alar defects involving the upper lip, reconstructive surgeons face the need for various thicknesses of tissues crucial to preserving the facial sulcus which is important for a cosmetically acceptable result. Our aim was to reconstruct the deep perialar and thinner lateral nasal alar defect in a single step procedure with a suitable flap which is reliable, has appropriate blood supply and provides an esthetically good result. MATERIALS AND METHODS: Extended alar defect was reconstructed with a combined flap in 10 cases...
January 15, 2019: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Katherine De Rome, Elinor Warner, Kostas Barkas, Nick Thomas, Sinan Barazi, Pavol Surda
Hemopatch (HE) advanced hemostatic pad composed of collagen and a synthetic, protein-reactive monomer which polymerises on contact with protein containing body fluids such as blood and CSF to seal tissues. HE is readily available which shortens the operating time, and may be manipulated intra-nasally to reconstruct defects of the anterior skull base. Reconstruction using HE reduces the morbidity compared with traditional facia lata graft harvesting techniques. Length of stay and operative times might be decreased due to lower morbidity from donor site complications...
January 15, 2019: Clinical Otolaryngology
Gregory Hansen, Joshua Hochman, Meghan Garner, Jeffrey Dmytrowich, Tanya Holt
BACKGROUND: Delivery of noninvasive ventilation commonly occurs in the pediatric intensive care unit (PICU). With the advent of high flow nasal cannula (HFNC), patients with respiratory distress may be rescued on the ward without a PICU admission. We evaluated our ward HFNC algorithm to determine its safety profile and independent predictors for non-responders, defined as requiring a subsequent PICU admission. METHODS: A retrospective chart review for patients <17 years of age admitted with respiratory distress between 2016-17...
January 15, 2019: Pediatrics International: Official Journal of the Japan Pediatric Society
Angela Maria Bezerra Varella, Germán Augusto Murrieta Morey, José Celso de Oliveira Malta
INTRODUCTION: Copepods are common components in all types of fish assemblages, being present in fishes of all ecosystems. The Ergasilidae Burmeister, 1835 is one of the biggest families in the order Cyclopoida Burmeister, 1834, with the majority of species found on freshwater fishes. MATERIAL AND METHODS: Ergasilus tipurus n. sp. is described from the nasal fossae of Calophysus macropterus and Sorubim lima captured in the rivers Guaporé and Mamoré in the State of Rondônia, Brazil, and from the nasal fossae and the gills of Rhaphiodon vulpinus collected from floodplain lakes of the Solimões River in the State of Amazonas, Brazil...
January 14, 2019: Acta Parasitologica
Fatih Alper Akcan, Yusuf Dündar, Hümeyra Bayram Akcan, Ahmet Uluat, Derya Cebeci, İlhan Ünlü
OBJECTIVES: The main purpose of the current study was to investigate nasal mucociliary clearance time (NMC) in patients with Vitamin-D deficiency. METHODS: A total of 55 patients with Vitamin-D deficiency and 32 controls were evaluated. NMC time was measured with subjective saccharine test and compared between study and control groups. In addition, NMC time was re-evaluated after Vitamin-D replacement protocol in patients with Vitamin-D deficiency. RESULTS: The mean 25(HO)Vitamin-D levels were 14...
January 14, 2019: European Archives of Oto-rhino-laryngology
Karim Zaoui, Reinald Kuehle, Ingo Baumann, Dorothee Laura Schuessler, Oliver Ristow, Michaela Plath, Christian Freudlsperger
OBJECTIVES: Orthognathic surgery is a well-established procedure for skeletal deformities. Beneficial influences to the posterior airway space (PAS) have been described, but little is known about the subjective aesthetical and functional nasal aspects after orthognathic surgery. The aim of this study was to evaluate nasal airflow by anterior rhinomanometry and volumetric changes in the nasal airway space after mono- or bimaxillary surgery using cone-beam computed tomography (CBCT) and a new segmentation software...
January 14, 2019: European Archives of Oto-rhino-laryngology
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