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https://www.readbyqxmd.com/read/28927770/-pyomyositis-in-children-two-cases-of-staphylococcus-aureus-infection
#1
F Gravot, J Hébert, A Robert-Dehault, R Bouttier, F Le Gall, G Blondin, P Vic
Pyomyositis is a term used to denote primary pyogenic infection of a skeletal muscle. It is a rare disease that was first described in immunodeficient patients living in tropical climates. Lately, however, cases involving healthy children have been described in temperate climates. The origin of primary pyomyositis remains unclear, although it is thought to be caused by seeding from transient bacteremia. Onset of disease is insidious, therefore necessitating rapid diagnosis to successfully select appropriate antibiotic therapy and avoid complications...
September 15, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28918656/diagnosing-kingella-kingae-infections-in-infants-and-young-children
#2
Pablo Yagupsky
Kingella kingae is currently recognized as the prime etiology of skeletal system infections in children aged 6-48 months. The organism is notoriously fastidious, its growth is inhibited by synovial fluid and bone exudates, and its presence in clinical specimens is commonly missed by traditional culture methods. Areas covered. The present review discusses the use of improved laboratory methods to detect the organism in normally sterile body fluids, exudates, and upper respiratory tract specimens. Expert commentary...
September 18, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28901427/microrna%C3%A2-106b-regulates-skeletal-muscle-insulin-sensitivity-and-glucose-homeostasis-by-targeting-mitofusion%C3%A2-2
#3
Ying Zhang, Wei He, Yuan-Fu Gao, Zhong-Min Fan, Chun-Lin Gao, Zheng-Kun Xia
MicroRNA‑106b (miR‑106b) is reported to be closely associated with skeletal muscle insulin resistance. The present study further investigated the role of miR‑106b in skeletal muscle insulin sensitivity and glucose homeostasis in vivo. Mice were randomly divided into 4 groups and infected with lentivirus expressing miR‑106b (miR‑106b mice), miR‑106b sponge (miR‑106b inhibition mice) or the corresponding empty vectors. Mitofusion‑2 (Mfn2) protein expression levels and glucose transporter (Glut)‑4 protein translocation were significantly reduced in the muscle of miR‑106b mice, whereas they were unaffected in miR‑106b inhibition mice...
September 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28894710/incidence-of-medication-discrepancies-and-its-predicting-factors-in-emergency-department
#4
Morvarid Zarif-Yeganeh, Mansoor Rastegarpanah, Gholamreza Garmaroudi, Molouk Hadjibabaie, Hojjat Sheikh Motahar Vahedi
BACKGROUND: This study was conducted to evaluate the incidence of medication discrepancies and its related factors using medication reconciliation method in patients admitted to the emergency department of Tehran University of Medical Sciences hospitals. METHODS: In this cross-sectional study, 200 adult patients with at least one chronic disease that used two regular prescription medications were included in 2015. After 24 h of admission, demographic data and patient's home medications were collected...
August 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28888386/pediatric-chronic-osteomyelitis-in-the-outskirts-of-al-ushbuna-carnide-lisboa-portugal
#5
Ana Tavares, Calil Makhoul, Mário Monteiro, Francisco Curate
The skeletal remains of seven individuals (five non-adults and two adults) were recovered during an archeological intervention in the township of Carnide (Lisbon, Portugal). Funerary anthropology strongly suggests that the sample is from the Medieval Islamic period (8th - 12th centuries AD). This report presents a case of chronic osteomyelitis in a non-adult individual. The diagnostic is substantiated by the presence of pathognomonic signs of osteomyelitis, including the presence of cloacae and a sequestrum in the left tibia...
September 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28879439/mannose-binding-lectin-mbl-deficiency-and-tuberculosis-infection-in-patients-with-ankylosing-spondylitis
#6
Renato Nisihara, Thelma Skare, Vinícius Maestri, Juliana S Alegretti, Ana Paula B Campos, Iara Messias-Reason
Ankylosing spondylitis (AS) patients may have higher prevalence of mannose-binding lectin (MBL) deficiency than normal individuals. MBL deficiency may influence susceptibility to infections. The aim of the study was to verify if MBL deficiency in patients with AS predisposes to infections. We studied 60 patients with AS diagnosed according to the Assessment of SpondyloArthritis international Society (ASAS) criteria. These patients had their MBL serum levels determinated. Twenty-five individuals were identified as MBL deficient (serum values 100 ng/mL)...
September 6, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28858401/histopathology-of-middle-east-respiratory-syndrome-coronovirus-mers-cov-infection-clinicopathological-and-ultrastructural-study
#7
Khaled O Alsaad, Ali H Hajeer, Mohammed Al Balwi, Mohammed Al Moaiqel, Nourah Al Oudah, Abdulaziz Al Ajlan, Sameera AlJohani, Sami Alsolamy, Giamal E Gmati, Hanan Balkhy, Hamdan H Al-Jahdali, Salim A Baharoon, Yaseen M Arabi
AIMS: The pathogenesis, viral localization and histopathological features of Middle East Respiratory Syndrome - Coronavirus (MERS-CoV) in human are not sufficiently described. The aims of this study were to explore and define the spectrum of histological and ultrastructural pathological changes affecting various organs in a patient with MERS-CoV infection and represent a base of MERS-CoV histopathology. METHODS AND RESULTS: We analyzed the postmortem histopathological findings and investigated viral particles localization in the pulmonary and extra-pulmonary tissue by transmission electron microscopic examination in a 33-year-old male patient of T-cell lymphoma, who acquired MERS-CoV infection...
August 31, 2017: Histopathology
https://www.readbyqxmd.com/read/28855175/infections-and-respiratory-tract-disease-as-risk-factors-for-idiopathic-inflammatory-myopathies-a-population-based-case-control-study
#8
John Svensson, Marie Holmqvist, Ingrid E Lundberg, Elizabeth V Arkema
OBJECTIVES: To investigate the association between infection or respiratory tract disease and future risk of developing idiopathic inflammatory myopathy (IIM). METHODS: A case-control study was performed using Swedish nationwide registers. Adults with newly diagnosed IIM were identified (2002-2011) from the National Patient Register (NPR) and the Swedish Rheumatology Register (n=957). Controls were matched by age, sex and place of residence (n=9476). Outpatient visits and hospitalisations preceding IIM diagnosis indicating infection or respiratory disease were identified from NPR...
August 30, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28842895/skeletal-muscle-lysosomal-function-via-cathepsin-activity-measurement
#9
Kristyn Gumpper, Matthew Sermersheim, Michael X Zhu, Pei-Hui Lin
Muscle wasting or cachexia is commonly associated with aging and many diseases such as cancer, infection, autoimmune disorders, and trauma. Decrease in muscle mass, or muscle atrophy, is often caused by dysfunction of protein proteolytic systems, such as lysosomes, which regulate protein turnover and homeostasis. Lysosomes contain many hydrolases and proteases and, thus, represent the major organelle that control protein turnover. Recently, lysosomes have emerged as a signaling hub to integrate cellular functions of nutrient sensing and metabolism, autophagy, phagocytosis, and endocytosis, which are all related to tissue homeostasis...
August 27, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28841684/infection-with-purified-piscine-orthoreovirus-demonstrates-a-causal-relationship-with-heart-and-skeletal-muscle-inflammation-in-atlantic-salmon
#10
Øystein Wessel, Stine Braaen, Marta Alarcon, Hanne Haatveit, Norbert Roos, Turhan Markussen, Torstein Tengs, Maria K Dahle, Espen Rimstad
Viral diseases pose a significant threat to the productivity in aquaculture. Heart- and skeletal muscle inflammation (HSMI) is an emerging disease in Atlantic salmon (Salmo salar) farming. HSMI is associated with Piscine orthoreovirus (PRV) infection, but PRV is ubiquitous in farmed Atlantic salmon and thus present also in apparently healthy individuals. This has brought speculations if additional etiological factors are required, and experiments focusing on the causal relationship between PRV and HSMI are highly warranted...
2017: PloS One
https://www.readbyqxmd.com/read/28839518/extrahepatic-metastasis-of-hepatocellular-carcinoma-to-the-paravertebral-muscle-a-case-report
#11
Kazuhiro Takahashi, Krishna G Putchakayala, Mohamed Safwan, Dean Y Kim
Identification of extrahepatic metastases (EHM) of hepatocellular carcinoma (HCC) has been paradoxically increasing due to an increase in the survival of HCC patients. However, metastasis of HCC to the skeletal muscle tissue is extremely rare. We describe a unique case of HCC metastasizing to the paravertebral muscle. A 55-year-old man with a history of hepatitis B cirrhosis underwent partial liver resection with complete removal of HCC. Three months later, a computed tomography (CT) scan showed intrahepatic recurrence...
August 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28839352/reconstruction-of-traumatic-bone-loss-using-the-induced-membrane-technique-preliminary-results-about-11-cases
#12
Noufanangue Kanfitine Kombate, Atchi Walla, Gamal Ayouba, B Moïse Bakriga, Yaovi Yannick Dellanh, Anani Grégoire Abalo, Assang Michel Dossim
INTRODUCTION: The use of Masquelet technique is a serious option to consider for biologic reconstruction of severe bone loss. Here is exposed a continuous and prospective study on bone loss management using that technique. The aims of this study were to assess epidemiology of bone loss due either to trauma or to non-unions and to give preliminary results. PATIENTS AND METHODS: It was a prospective study from April 2015 to december 2016 involving patients treated using the induced membrane technique for a diaphyseal bone defect due either to trauma or non-unions...
December 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28837368/advances-in-the-local-and-targeted-delivery-of-anti-infective-agents-for-management-of-osteomyelitis
#13
Caleb A Ford, James E Cassat
Osteomyelitis, a common and debilitating invasive infection of bone, is a frequent complication following orthopedic surgery and causes pathologic destruction of skeletal tissues. Bone destruction during osteomyelitis results in necrotic tissue, which is poorly penetrated by antibiotics and can serve as a nidus for relapsing infection. Osteomyelitis therefore frequently necessitates surgical debridement procedures, which provide a unique opportunity for targeted delivery of antimicrobial and adjunctive therapies...
September 1, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28831331/salvage-of-infected-nasal-reconstruction-with-a-polymethyl-methacrylate-spacer
#14
Pedro C Cavadas, Alessandro Thione, Yvan D Pacheco
Total nasal reconstruction is a challenging multistage procedure. Infections can destroy the cartilage framework and seriously compromise the result. The use of polymethyl methacrylate with antibiotics as a spacer has been described in the treatment of skeletal infections. Using this same principle, the use of a polymethyl methacrylate with antibiotics spacer for an infected nasal reconstruction is reported in a clinical case.
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28828951/clinical-outcomes-of-patient-specific-porous-titanium-endoprostheses-in-dogs-with-tumors-of-the-mandible-radius-or-tibia-12-cases-2013-2016
#15
Jonathan P Bray, Andrew Kersley, Warwick Downing, Katherine R Crosse, Andrew J Worth, Arthur K House, Guy Yates, Alastair R Coomer, Ian W M Brown
OBJECTIVE To characterize the processes involved in and outcomes achieved with custom-designed patient-specific implants to provide functional replacement of skeletal structures in dogs with tumors of the mandible, radius, or tibia. DESIGN Prospective case series. ANIMALS 6 dogs with mandibular tumors, 5 with tumors of the distal aspect of the radius, and 1 with a tumor in the distal aspect of the tibia treated from June 2013 to September 2016 at 3 referral centers. PROCEDURES After tumor staging, implants were designed from patients' CT scans by means of various computer-aided design applications and printed by means of selective laser melting in titanium-6 aluminum-4 vanadium alloy...
September 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28827507/presentation-coagulopathy-and-persistent-acidosis-predict-complications-in-orthopaedic-trauma-patients
#16
Benjamin R Childs, Daniel R Verhotz, Timothy A Moore, Heather A Vallier
OBJECTIVES: To evaluate the ability of measures of coagulopathy and acidosis to predict complications. We hypothesize that increased coagulopathy and acidosis over the first 60 hours of hospitalization will result in increased rates of infection and mortality. DESIGN: Prospective, observational. SETTING: Level 1 trauma center. PATIENTS: Three hundred and seventy-six skeletally mature patients with an Injury Severity Score (ISS) greater than 16 who were surgically treated for high energy fractures of the femur, pelvic ring, acetabulum, and/or spine...
August 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28822807/spontaneous-activation-of-a-mavs-dependent-antiviral-signaling-pathway-determines-high-basal-interferon-%C3%AE-expression-in-cardiac-myocytes
#17
Efraín E Rivera-Serrano, Nicole DeAngelis, Barbara Sherry
Viral myocarditis is a leading cause of sudden death in young adults as the limited turnover of cardiac myocytes renders the heart particularly vulnerable to viral damage. Viruses induce an antiviral type I interferon (IFN-α/β) response in essentially all cell types, providing an immediate innate protection. Cardiac myocytes express high basal levels of IFN-β to help pre-arm them against viral infections, however the mechanism underlying this expression remains unclear. Using primary cultures of murine cardiac and skeletal muscle cells, we demonstrate here that the mitochondrial antiviral signaling (MAVS) pathway is spontaneously activated in unstimulated cardiac myocytes but not cardiac fibroblasts or skeletal muscle cells...
October 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28821219/early-congenital-syphilis-recognising-symptoms-of-an-increasingly-prevalent-disease
#18
Nupur U Patel, Elias Oussedik, Erin T Landis, Lindsay C Strowd
BACKGROUND: Congenital syphilis (CS) is an infectious disease resulting from transplacental transmission of Treponema pallidum spirochetes from an infected mother to fetus during pregnancy. While uncommon, CS has shown an increased incidence in Canada and the United States since 2001 and 2012, respectively. CASE REPORT: We present the case of a 5-week-old female infant with blistering rash on the palms and soles. The infant displayed decreased movement of the left upper extremity, clinically consistent with Parrot pseudoparalysis...
August 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28819829/surgical-treatment-for-symptomatic-non-ossifying-fibromas-of-the-lower-extremity-with-calcium-sulfate-grafts-in-skeletally-immature-patients
#19
Antonio Andreacchio, Flavia Alberghina, Gianluca Testa, Federico Canavese
BACKGROUND: Non-ossifying fibromas (NOFs) are common benign bone lesions found in children and adolescents. They usually involve metaphysis of long bones, tend to gradually disappear with age and usually do not require surgery, while they are not associated with pathological fractures. The aim of this study was to evaluate the outcome and efficacy of a single-stage procedure, comprising curettage of the lesion and calcium sulfate pellet (CaSP) grafting, in skeletally immature patients with large, symptomatic NOF of the lower extremity, and the possible limitations of the procedure...
August 17, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28803536/bovine-viral-diarrhea-virus-1b-fetal-infection-with-extensive-hemorrhage
#20
Robert W Fulton, Anthony W Confer, Nicholas J Sorensen, Julia F Ridpath, Lurinda J Burge
Bovine viral diarrhea virus (BVDV) 1b was isolated from tissues of a term bovine fetus with petechial hemorrhages noted throughout the body and placenta at autopsy. Fresh lung, kidney, thymus, and liver tissues were examined by direct fluorescent antibody testing and were positive for BVDV antigen and negative for bovine herpesvirus 1 antigen. An organ pool of fresh tissues was positive for noncytopathic (NCP) BVDV-1 by virus isolation. BVDV-1b was identified by sequencing of the 5'-UTR region of the genome...
August 1, 2017: Journal of Veterinary Diagnostic Investigation
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