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https://www.readbyqxmd.com/read/28550171/%C3%AE-adrenergic-receptor-stimulation-inhibits-proarrhythmic-alternans-in-post-infarction-border-zone-cardiomyocytes-a-computational-analysis
#1
Jakub Tomek, Blanca Rodriguez, Gil Bub, Jordi Heijman
The border zone (BZ) of viable myocardium adjacent to an infarct undergoes extensive autonomic and electrical remodelling and is prone to repolarisation alternans-induced cardiac arrhythmias. BZ remodelling processes may promote or inhibit calcium and/or repolarisation alternans and may differentially affect ventricular arrhythmogenesis. Here, we employed a detailed computational model of the canine ventricular cardiomyocyte to study the determinants of alternans in the BZ and their regulation by β-adrenergic receptor (βAR) stimulation...
May 26, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28549551/age-estimation-by-the-cameriere-s-normalized-measurements-cnm-of-the-single-permanent-mandibular-tooth-on-a-panoramic-radiograph
#2
Ivan Galić, Andrea Pacifici, Daniele Carbone, Luciano Pacifici, Ana Jerončić, Roberto Cameriere
In this study Cameriere's normalized measurements (CNM) of a single mandibular tooth were evaluated for age estimation on a sample of ortopantomographies (OPTs) of 2223 Italian children aged between 4 and 15years. Dental maturity was radiographically evaluated by CNM of the seven left permanent mandibular teeth (CNMi=Ai/Li, i=1,…,7); in monoradicular teeth, the distance (Ai, i=1,…,5) between the inner sides of the open apex was measured while in biradicular teeth (Ai, i=6, 7), the sum of the distances between the inner sides of the two open apices was calculated...
May 2017: Legal Medicine
https://www.readbyqxmd.com/read/28549300/evaluation-of-the-in-vitro-effect-of-boldo-and-meadowsweet-plant-extracts-on-the-expression-of-antimicrobial-peptides-and-inflammatory-markers-in-canine-keratinocytes
#3
Domenico Santoro, Kim Ahrens, Ryan Vesny, Christelle Navarro, Hugues Gatto, Rosanna Marsella
Dogs with allergies are prone to skin infections and treatments/preventatives to boost innate immune-defenses are beneficial. The aim of this study was to evaluate the effects of Boldo and Meadowsweet extracts on the expression of β-defensins (cBD), cathelicidin (cCath), and pro-inflammatory cytokines in canine keratinocyte. This study had two phases. Phase I evaluated mRNA expression of cBD103 and cCath, and secretion of cCath, IL-8 and TNF-α by keratinocytes harvested from healthy (n=5) and atopic (n=5) age-matched beagles exposed to Boldo (2% to 0...
May 17, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28549201/cytogenetic-aspects-of-a-canine-breast-carcinosarcoma-a-case-report
#4
C S D Morais, P R A M Affonso, J A Bitencourt, A A Wenceslau
This study searched a rare and aggressive type of cancer in dogs and humans, the breast carcinosarcoma. Both clinical and pathological traits of mammary carcinosarcomas in dogs are similar to humans, such as infrequent occurrence, fast tumor growth, and unfavorable prognosis when compared to carcinomas. Other possible alterations include chromosomal abnormalities that can be useful for the identification of tumoral cells and diagnosis. The aim of this study was to compare the chromosomal features of peripheral lymphocytes and tumor cells in a mammary carcinosarcoma of a 14-year-old female Poodle...
May 25, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28548887/effects-of-bone-morphogenetic-protein-2-on-vertical-bone-augmentation-in-a-canine-model
#5
Yung-Ting Hsu, Khalid Al-Hezaimi, Pablo Galindo-Moreno, Francisco O'Valle, Abdulaziz Al-Rasheed, Hom-Lay Wang
BACKGROUND: Vertical bone augmentation (VBA) remains unpredictable and challenging for most clinicians. This study was aimed to compare hard tissue outcomes of VBA, with and without rhBMP-2, under space-making titanium mesh in a canine model. METHODS: Eleven male beagle dogs were used in the study. Experimental ridge defects were created to form atrophic ridges. VBA was performed via guide bone regeneration (GBR) using titanium mesh and allografts. In experimental hemimandibles, rhBMP-2/ACS was well mixed with allografts prior to procedures, whereas a control buffer was applied within controls...
May 26, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28548682/arthrotomy-based-pre-clinical-models-of-particle-induced-osteolysis-a-systematic-review
#6
REVIEW
Meghan M Moran, Brittany M Wilson, Ryan D Ross, Amarjit S Virdi, D Rick Sumner
We completed a systematic literature review of in vivo animal models that use arthrotomy-based methods to study particle-induced peri-implant osteolysis. The purpose of the review was to characterize the models developed to date, to determine the questions addressed, to assess scientific rigor and transparency and to identify gaps in knowledge. We probed three literature databases (Medline, Embase and Scopus) and found 77 manuscripts that fit the search parameters. In the most recent 10 years, researchers mainly used rat and mouse models, whereas in the previous 20 years large animal, canine and rabbit models were more common...
May 26, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28547920/pulmonary-pythiosis-in-a-canine-patient
#7
Darin Kepler, Robert Cole, Tekla Lee-Fowler, Jey Koehler, Stephanie Shrader, Joe Newton
A Staffordshire terrier presented for evaluation of a chronic, nonproductive cough that was unresponsive to antibiotic therapy. A large mass identified in the pulmonary hilum was most consistent with tracheobronchial lymphadenopathy on radiographic and computed tomography (CT) images. Bronchoscopy confirmed a mass compressing the dorsal portion of the intrathoracic trachea. Bronchoscopic biopsies of the tracheal mass revealed necrosuppurative and eosinophilic inflammation with intralesional Pythium insidiousum hyphae...
May 25, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28545900/environmental-contamination-with-toxocara-spp-eggs-in-public-parks-and-playground-sandpits-of-greater-lisbon-portugal
#8
David Otero, Ana Margarida Alho, Rolf Nijsse, Jeroen Roelfsema, Paul Overgaauw, Luís Madeira de Carvalho
Toxocarosis is a zoonotic parasitic disease transmitted from companion animals to humans. Environmental contamination with Toxocara eggs is considered to be the main source of human infections. In Portugal, knowledge regarding the current situation, including density, distribution and environmental contamination by Toxocara spp., is largely unknown. The present study investigated environmental contamination with Toxocara spp. eggs, in soil and faecal samples collected from public parks and playground sandpits in Greater Lisbon, Portugal...
May 22, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28545817/pre-screening-of-crude-peptides-in-a-serological-bead-based-suspension-array
#9
Tinka Jelsma, Fimme J van der Wal, Helmi Fijten, Nicolas Dailly, Evert van Dijk, Willie L Loeffen
Most serological assays detect antibody responses in biological samples through affinity of serum antibodies for antigens provided in the assay. Certain antigens, however, may be difficult to produce and/or may contain unwanted epitopes. In these cases, a practical alternative may be the use of peptides as representatives for specific epitopes. Peptides can be obtained after purification in large quantities for a modest price, but screening of a large set of peptides during development may be relatively expensive...
May 22, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28545521/clinical-serological-and-echocardiographic-examination-of-healthy-field-dogs-before-and-after-vaccination-with-a-commercial-tetravalent-leptospirosis-vaccine
#10
Andrea M Spiri, Sabrina Rodriguez-Campos, José M Matos, Tony M Glaus, Barbara Riond, Claudia E Reusch, Regina Hofmann-Lehmann, Barbara Willi
BACKGROUND: Leptospirosis is a re-emerging bacterial zoonosis caused by spirochetes of the genus Leptospira. Severe disease has been reported in dogs in Europe despite vaccination with bivalent Leptospira vaccines. Recently, a tetravalent canine Leptospira vaccine (Nobivac® L4) was licenced in Europe. The goal of this study was to investigate clinical signs, microscopic agglutination test (MAT) titres, haematology, blood biochemistry, cardiac (c) Troponin I levels and echocardiography before and after vaccination with this tetravalent vaccine...
May 25, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28545439/distribution-of-white-spot-lesions-among-orthodontic-patients-attending-teaching-institutes-in-khartoum
#11
Maha Kamal Eltayeb, Yahia Eltayeb Ibrahim, Ikhlas Ali El Karim, Nada Mirghani Sanhouri
BACKGROUND: Fixed orthodontic appliances render teeth cleaning arduous, thus when orthodontic treatment is associated with inadequate oral hygiene practice, development of white spot lesions (WSLs) imposes a significant risk on the dentition. Salivary reservoir of calcium, magnesium, phosphorous and fluoride counteracts demineralization and encourages remineralization providing protection against caries challenge. The investigation of the factors leading to WSLs' development is mandatory for appropriate prevention strategies planning...
May 25, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28545071/characterization-of-the-urinary-microbiome-in-healthy-dogs
#12
Erin N Burton, Leah A Cohn, Carol N Reinero, Hans Rindt, Stephen G Moore, Aaron C Ericsson
The urinary bladder in healthy dogs has dogmatically been considered free of bacteria. This study used culture independent techniques to characterize the healthy canine urinary microbiota. Urine samples collected by antepubic cystocentesis from dogs without urinary infection were used for DNA extraction. Genital tract and rectal samples were collected simultaneously from the same dogs. The V4 hypervariable region of the 16S rRNA bacterial gene was amplified and compared against Greengenes database for OTU assignment and relative abundance for urine, genital, and rectal samples...
2017: PloS One
https://www.readbyqxmd.com/read/28544909/can-human-allergy-drug-fexofenadine-an-antagonist-of-histamine-h1-receptor-be-used-to-treat-dog-and-cat-homology-modeling-docking-and-molecular-dynamic-simulation-of-three-h1-receptors-in-complex-with-fexofenadine
#13
Safaa Sader, Jun Cai, Anna C G Muller, Chun Wu
Fexofenadine, a potent antagonist to human histamine 1 (H1) receptor, is a non-sedative third generation antihistamine that is widely used to treat various human allergic conditions such as allergic rhinitis, conjunctivitis and atopic dermatitis. Encouragingly, it's been successfully used to treat canine atopic dermatitis, this supports the notion that it might have a great potential for treating other canine allergic conditions and other mammal pets such as dog. Regrettably, while there is a myriad of studies conducted on the interactions of antihistamines with human H1 receptor, the similar studies on non-human pet H1 are considerably scarce...
May 17, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28544776/comparison-of-histologic-margin-status-in-low-grade-cutaneous-and-subcutaneous-canine-mast-cell-tumours-examined-by-radial-and-tangential-sections
#14
C B Dores, M Milovancev, D S Russell
BACKGROUND: Radial sections are widely used to estimate adequacy of excision in canine cutaneous mast cell tumours (MCTs); however, this sectioning technique estimates only a small fraction of total margin circumference. This study aimed to compare histologic margin status in grade II/low grade MCTs sectioned using both radial and tangential sectioning techniques. MATERIALS AND METHODS: A total of 43 circumferential margins were evaluated from 21 different tumours...
May 23, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28544701/intradiscal-application-of-a-pcla-peg-pcla-hydrogel-loaded-with-celecoxib-for-the-treatment-of-back-pain-in-canines-what-s-in-it-for-humans
#15
Anna R Tellegen, Nicole Willems, Martijn Beukers, Guy C M Grinwis, Saskia G M Plomp, Clemens Bos, Maarten van Dijk, Mike de Leeuw, Laura B Creemers, Marianna A Tryfonidou, Björn P Meij
Chronic low back pain is a common clinical problem in both the human and canine population. Current pharmaceutical treatment often consists of oral anti-inflammatory drugs to alleviate pain. Novel treatments for degenerative disc diseases focus on local application of sustained released drug formulations. The aim of this study was to determine safety and feasibility of intradiscal application of a PCLA-PEG-PCLA hydrogel releasing celecoxib, a COX-2 inhibitor. Biocompatibility was evaluated after subcutaneous injection in mice and safety of intradiscal injection of the hydrogel was evaluated in experimental dogs with early spontaneous intervertebral disc (IVD) degeneration...
May 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28544149/what-s-in-a-name-the-incorrect-use-of-case-series-as-a-study-design-label-in-studies-involving-dogs-and-cats
#16
J M Sargeant, A M O'Connor, J N Cullen, K M Makielski, A Jones-Bitton
BACKGROUND: Study design labels are used to identify relevant literature to address specific clinical and research questions and to aid in evaluating the evidentiary value of research. Evidence from the human healthcare literature indicates that the label "case series" may be used inconsistently and inappropriately. OBJECTIVE: Our primary objective was to determine the proportion of studies in the canine and feline veterinary literature labeled as case series that actually corresponded to descriptive cohort studies, population-based cohort studies, or other study designs...
May 24, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28544057/interventional-closure-of-a-patent-ductus-arteriosus-using-an-amplatz-canine-duct-occluder-in-an-alpaca-cria
#17
E C Chapel, J Lozier, J Lakritz, K E Schober
A 6-month old female alpaca cria presented to The Ohio State University for evaluation of a cardiac murmur. Echocardiography revealed a left-to-right shunting patent ductus arteriosus, a restrictive left-to-right shunting perimembranous ventricular septal defect, and secondary moderate left atrial and ventricular dilation. Aortic root angiography demonstrated a type IIA patent ductus arteriosus (PDA). Interventional closure of the PDA was successfully performed, without complication, using an Amplatz canine duct occluder...
May 24, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28544017/evaluation-of-canine-adverse-food-reactions-by-patch-testing-with-single-proteins-single-carbohydrates-and-commercial-foods
#18
Cornelia Johansen, Claire Mariani, Ralf S Mueller
BACKGROUND: Adverse food reaction (AFR) is an important differential diagnosis for the pruritic dog. It is usually diagnosed by feeding an elimination diet with a novel protein and carbohydrate source for eight weeks followed by subsequent food provocation. A previous study demonstrated that patch testing dogs with foods had a high sensitivity and negative predictability for selection of elimination diet ingredients. HYPOTHESIS/OBJECTIVES: The aim of this study was to investigate patch testing with proteins, carbohydrates and dry commercial dog food in dogs to determine whether there was value in patch testing to aid the diagnosis of canine adverse food reaction...
May 22, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28543780/intranasal-midazolam-versus-rectal-diazepam-for-the-management-of-canine-status-epilepticus-a-multicenter-randomized-parallel-group-clinical-trial
#19
M Charalambous, S F M Bhatti, L Van Ham, S Platt, N D Jeffery, A Tipold, J Siedenburg, H A Volk, D Hasegawa, A Gallucci, G Gandini, M Musteata, E Ives, A E Vanhaesebrouck
BACKGROUND: Intranasal administration of benzodiazepines has shown superiority over rectal administration for terminating emergency epileptic seizures in human trials. No such clinical trials have been performed in dogs. OBJECTIVE: To evaluate the clinical efficacy of intranasal midazolam (IN-MDZ), via a mucosal atomization device, as a first-line management option for canine status epilepticus and compare it to rectal administration of diazepam (R-DZP) for controlling status epilepticus before intravenous access is available...
May 24, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28543304/biomechanical-comparison-between-pins-and-polymethylmethacrylate-and-the-sop-locking-plate-system-to-stabilize-canine-lumbosacral-fracture-luxation-in-flexion-and-extension
#20
Johannes J Nel, Cor-Jacques Kat, Gert L Coetzee, Paul J van Staden
OBJECTIVE: To determine the stability of a simulated complete L7-S1 fracture-luxation immobilized with SOP locking plate system, compared to pins and polymethylmethacrylate (PMMA). STUDY DESIGN: In vitro biomechanical study. ANIMALS: Cadaver specimens of 18 skeletally mature large-breed dogs. MATERIALS AND METHODS: Specimens were randomly stabilized with one of the two fixation techniques. Lumbosacral spine specimens (L5-S3) were subjected to a bending moment applied to the caudal and cranial ends of the specimen...
May 24, 2017: Veterinary Surgery: VS
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