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https://www.readbyqxmd.com/read/28929544/computed-tomographic-appearance-of-canine-tonsillar-neoplasia-14-cases
#1
Florence Thierry, Maurizio Longo, Evi Pecceu, Davide D Zani, Tobias Schwarz
The palatine tonsil is an uncommon site of oral canine neoplasia. For affected tonsils, squamous cell carcinoma is the most frequent type of neoplasia, followed by melanoma and lymphoma. Computed tomography (CT) is increasingly used for investigation of canine oropharyngeal pathology; however, limited information is available on the CT appearance of tonsillar neoplasms. Objectives of this retrospective descriptive case series were to characterize the CT features of canine tonsillar neoplasia and determine whether specific CT features differentiate nonneoplastic from neoplastic tonsils...
September 19, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28929498/dog-skin-parasite-load-tlr-2-il-10-and-tnf-%C3%AE-expression-and-infectiousness
#2
Dandara Camila Morais Pereira-Fonseca, Fernanda Muller de Oliveira-Rovai, Lílian Aparecida Colebrusco Rodas, Carolina Aparecida Carlin Beloti, Rafaela Beatriz Pintor Torrecilha, Píer Kenji Rauschkolb Katsuda Ito, Saulo Vinícius Avanço, Rafael Silva Cipriano, Yuri Tani Utsunomiya, Roberto Mitsuyoshi Hiramoto, Leontides Calvo-Bado, Orin Courtenay, Gisele Fabrino Machado, Valéria Marçal Felix de Lima, Cáris Maroni Nunes
Visceral leishmaniosis is a zoonotic disease that is transmitted by Lutzomyia longipalpis sandflies. Dogs are the main peri-urban reservoir of the disease, and progression of canine leishmaniosis is dependent on the type of immune response elaborated against the parasite. Type 1 immunity is characterized by effective cellular response, with production of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α). In contrast, Type 2 immunity is predominantly humoral, associated with progression of the disease, and mediated by anti-inflammatory cytokines such as interleukin 10 (IL-10)...
September 20, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28929101/current-trends-in-volume-replacement-therapy-and-the-use-of-synthetic-colloids-in-small-animals-an-internet-based-survey-2016
#3
Ivayla D Yozova, Judith Howard, Nadja E Sigrist, Katja-Nicole Adamik
The use of synthetic colloids (SCs), particularly hydroxyethyl starch (HES), in people has changed in recent years following new evidence raising concerns about their efficacy and safety. Although fluid therapy guidelines for small animals are often extrapolated from human medicine, little information exists on current practice in veterinary medicine. The objective of the present study was to investigate current fluid selection, use of plasma volume expanders including SCs, and recent changes in their use in small animal practice...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28928992/dental-implant-in-the-canalis-sinuosus-a-case-report-and-review-of-the-literature
#4
José Alcides Arruda, Pedro Silva, Luciano Silva, Pâmella Álvares, Leni Silva, Ricardo Zavanelli, Cleomar Rodrigues, Marleny Gerbi, Ana Paula Sobral, Marcia Silveira
The canalis sinuosus is a neurovascular canal, a branch of nerve of infraorbital canal, through which the anterior superior alveolar nerve passes and then leans medially in course between the nasal cavity and the maxillary sinus, reaching the premaxilla in the canine and incisor region. The purpose of this article is to report a case with the presence of canalis sinuosus, in order to alert and guide professionals and discuss the morphology of this anatomical variation avoiding trans- and postsurgical disorders in dental implants...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28927929/mechanical-characterization-of-structurally-porous-biomaterials-built-via-additive-manufacturing-experiments-predictive-models-and-design-maps-for-load-bearing-bone-replacement-implants
#5
D Melancon, Z S Bagheri, R B Johnston, L Liu, M Tanzer, D Pasini
Porous biomaterials can be additively manufactured with micro-architecture tailored to satisfy the stringent mechano-biological requirements imposed by bone replacement implants. In a previous investigation, we introduced structurally porous biomaterials, featuring strength five times stronger than commercially available porous materials, and confirmed their bone ingrowth capability in an in-vivo canine model. While encouraging, the manufactured biomaterials showed geometric mismatches between their internal porous architecture and that of its as-designed counterpart, as well as discrepancies between predicted and tested mechanical properties, issues not fully elucidated...
September 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28927435/detection-and-quantification-of-spirocerca-lupi-by-hrm-qpcr-in-fecal-samples-from-dogs-with-spirocercosis
#6
Alicia Rojas, Gilad Segev, Alex Markovics, Itamar Aroch, Gad Baneth
BACKGROUND: Spirocerca lupi, the dog oesophageal nematode, causes a potentially fatal disease in domestic dogs, and is currently clinically diagnosed by coproscopy and oesophagoscopy. To date, a single molecular method, a semi-nested PCR, targeting the cox1 gene, has been developed to aid in the diagnosis of spirocercosis. The present study describes three novel high-resolution melt (HRM) quantitative PCR (qPCR) assays targeting fragments of the ITS1, 18S and cytb loci of S. lupi. The performance of these molecular assays in feces was compared to fecal flotation and to the previously described cox1 gene semi-nested PCR in 18 fecal samples from dogs with clinical oesophageal spirocercosis diagnosed by oesophagoscopy...
September 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28927257/differential-and-correlated-expression-of-p16-p21-p27-p38-in-mammary-gland-tumors-of-aged-dogs
#7
Hyun-Woo Kim, Jong-Il Shin, Byung-Joon Seung, Jung-Hyung Ju, Jung-Hyang Sur
The inhibitory effect of neutering on mammary gland tumor development in dogs is well known. However, we found that the effect of neutering on tumor malignancy may be altered by aging. Therefore, we aimed to characterize mammary tumors in aged dogs by analyzing the expression of cellular senescence markers, from the viewpoint of senescence. The expression of p16, p38, p21, and p27 antibodies, which are senescence-associated markers, was detected in canine mammary tumors of aged dogs via immunohistochemistry...
September 20, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28927253/comparative-aspects-of-microrna-expression-in-canine-and-human-cancer
#8
REVIEW
Kabiru Sahabi, Gayathri Thevi Selvarajah, Rasedee Abdullah, Cheah Yoke Kqueen, Tan Geok Chin
MicroRNAs (miRNAs) are important players in all biological pathways in multicellular organisms. Over 1,400 human miRNAs have been identified, and many are conserved among vertebrates and invertebrates. MicroRNA regulation is the most abundant mode of post-transcriptional gene regulation. MicroRNAs that are involved in the initiation and progression of cancers are termed oncomiRs, several of which have been identified in canine and human cancer. Similarly, several miRNAs have been reported to be down-regulated in cancers of the two species...
September 20, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28925085/-18-f-fdg-pet-ct-as-adjunctive-diagnostic-modalities-in-canine-fever-of-unknown-origin
#9
Megan Grobman, Leah Cohn, Stephanie Knapp, Jeffrey N Bryan, Carol Reinero
Fever of unknown origin (FUO) is a persistent or recurrent fever for which the underlying source has not been identified despite diagnostic investigation. In people, (18) F-fluoro-2-deoxyglucose positron emission tomography ((18) F-FDG-PET) alone or in combination with computed tomography (CT) is often beneficial in detecting the source of fever when other diagnostics have failed. Veterinary reports describing use of these modalities in animals with fever of unknown origin are currently lacking. Aims of this retrospective case series were to describe (18) F-FDG-PET or (18) F-FDG-PET/CT findings in a group of dogs with fever of unknown origin...
September 18, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28924718/comprehensive-annotation-and-evolutionary-insights-into-the-canine-canis-lupus-familiaris-antigen-receptor-loci
#10
Jolyon Martin, Hannes Ponstingl, Marie-Paule Lefranc, Joy Archer, David Sargan, Allan Bradley
Dogs are an excellent model for human disease. For example, the treatment of canine lymphoma has been predictive of the human response to that treatment. However, an incomplete picture of canine (Canis lupus familiaris) immunoglobulin (IG) and T cell receptor (TR)-or antigen receptor (AR)-gene loci has restricted their utility. This work advances the annotation of the canine AR loci and looks into breed-specific features of the loci. Bioinformatic analysis of unbiased RNA sequence data was used to complete the annotation of the canine AR genes...
September 19, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28924500/comparison-of-polybrominated-diphenyl-ethers-pbdes-and-polychlorinated-biphenyls-pcbs-in-the-serum-of-hypothyroxinemic-and-euthyroid-dogs
#11
Grace Lau, Kyla Walter, Philip Kass, Birgit Puschner
OBJECTIVE: To determine the profile of 14 polybrominated diphenyl ethers (PBDEs) and 23 polychlorinated biphenyls (PCBs) in serum of domestic canines and whether this was predictive of thyroid hormone status. SAMPLES: Serum samples were collected from 51 client-owned dogs visiting the University of California Davis William R. Pritchard Veterinary Medical Teaching Hospital during 2012 to 2016 for routine appointments. Fifteen dogs were diagnosed with hypothyroxinemia while 36 were euthyroid...
2017: PeerJ
https://www.readbyqxmd.com/read/28923708/enhanced-in%C3%A2-vitro-maturation-of-canine-oocytes-by-oviduct-epithelial-cell-co-culture
#12
Jingu No, Minghui Zhao, Seunghoon Lee, Sun A Ock, Yoonseok Nam, Tai-Young Hur
Canine-assisted reproductive techniques have been successful for several years; however, the lack of an oocyte in vitro maturation system has limited their application. The aim of this study was to evaluate the effect of canine oviduct epithelial cells (cOECs) on canine oocyte maturation in vitro. Specifically, the method used for isolation of cOECs did not affect the expression of epithelial markers, E-cadherin and cytokeratin, on fresh, cultured and cryopreserved cells. Moreover, BrdU analysis showed that cOECs cultured in Medium 171 supplemented with mammary epithelial growth supplement were more proliferative than counterparts in advanced Dulbecco's modified Eagle medium or Medium 199...
September 6, 2017: Theriogenology
https://www.readbyqxmd.com/read/28923543/selective-glucocorticoid-receptor-modulation-inhibits-cytokine-responses-in-a-canine-model-of-mild-endotoxemia
#13
J Bartko, U Derhaschnig, T Neels, G H Nabozny, C Harcken, J Leuschner, F De Vries, B Jilma
Selective glucocorticoid receptor modulators (GRMs) promise to reduce adverse events of glucocorticoids while maintaining anti-inflammatory potency. The present study tested the anti-inflammatory activity of two novel non-steroidal GRMs (GRM1: BI 607812 BS, GRM2: BI 653048 BS*H3PO4) in comparison to prednisolone in a canine model of low dose endotoxemia. This study compared the anti-inflammatory and pharmacokinetic profile of escalating daily oral doses of GRM1 (1, 2.5, 5 and 10mg/kg) and GRM2 (0.1, 0.25 and 1mg/kg) with prednisolone (0...
September 15, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28923372/in-vitro-tubulogenesis-of-madin-darby-canine-kidney-mdck-spheroids-occurs-depending-on-constituent-cell-number-and-scaffold-gel-concentration
#14
Tsuyoshi Hirashima, Miho Hoshuyama, Taiji Adachi
In vitro tubulogenesis has been employed as an experimental model system to study tissue morphogenesis of internal organs. It has been previously shown that Madin-Darby canine kidney (MDCK) cells form tubes in the presence of hepatocyte growth factor in 3D cultures. Although these cells are expected to form tube structures in some microenvironments independent of chemical stimulation, little is known about the cellular mechanisms in organizing such an anisotropic multicellular structure. Here, we report 3D culture conditions that induce MDCK tubulogenesis without growth factor stimulation...
September 15, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28921893/a-case-of-ocular-infection-with-onchocerca-lupi-in-a-dog-from-germany
#15
A Hodžić, B Hinney, S König, T J Naucke, G Duscher, A Joachim
Onchocerca lupi is an emerging zoonotic parasite infecting the ocular connective tissue of dogs, cats and humans. The only known case of canine ocular onchocerciasis in Germany was documented in 2002 in a shelter dog. However, the species of Onchocerca causing the infection could not be identified. Here, we report a case of the ocular infection with O. lupi in a dog, confirmed by PCR and sequencing of the cox1 gene. Further investigations are required to assess the risk factors for transmission and spread of the parasite in Germany...
September 17, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28921723/effect-of-prophylactic-cefalexin-treatment-on-the-development-of-bacterial-infection-in-acute-radiation-induced-dermatitis-in-dogs-a-blinded-randomized-controlled-prospective-clinical-trial
#16
Michele A Keyerleber, Lluís Ferrer
BACKGROUND: Acute radiation-induced dermatitis (ARID) is a common sequela of radiation therapy and carries the risk of secondary bacterial skin infection. No standard of care exists for managing canine ARID and evidence-based guidelines are lacking; however, prophylactic use of antibiotics is common. HYPOTHESIS/OBJECTIVES: To evaluate the impact of prophylactic cefalexin on the prevalence and severity of bacterial infection in canine ARID. ANIMALS: Seventeen dogs treated with definitive-intent radiotherapy...
September 18, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28921687/multimodal-treatment-of-a-dog-with-disseminated-cutaneous-viral-papillomatosis
#17
Britt J Levy, Susannah J Sample, Hang Yuan
BACKGROUND: Canine papillomaviruses (CPVs) are associated with varied cutaneous manifestations. Spontaneous resolution typically occurs within one to 12 months. This case report describes multimodal treatment of a dog with severe disseminated papillomatosis. CLINICAL SUMMARY: An eight-month-old, female spayed, mixed breed dog was presented with a two month history of rapidly progressing papillomatosis and lack of response to oral azithromycin therapy. The dog was severely pruritic and malodorous; the weight and growth of lesions had progressed to affect the dog's gait and vision, and led to decreased quality of life...
September 18, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28920893/a-functional-genetic-scheme-for-seizure-forecasting-in-canine-epilepsy
#18
E Bou Assi, D K Nguyen, S Rihana, M Sawan
OBJECTIVE: The objective of this work is the development of an accurate seizure forecasting algorithm that considers brain's functional connectivity for electrode selection. METHODS: We start by proposing Kmeans-directed transfer function, an adaptive functional connectivity method intended for seizure onset zone localization in bilateral intracranial EEG recordings. Electrodes identified as seizure activity sources and sinks are then used to implement a seizure-forecasting algorithm on long-term continuous recordings in dogs with naturallyoccurring epilepsy...
September 13, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28920795/evaluation-of-symmetric-dimethylarginine-as-an-early-biomarker-of-chronic-kidney-disease-in-captive-cheetahs-acinonyx-jubatus
#19
Benjamin Lamglait, Marielle Vandenbunder-Beltrame
Symmetric dimethylarginine (SDMA) has been shown to be a valuable biomarker for early detection of chronic kidney disease (CKD) in canine and feline patients. Recognition of early (subclinical) kidney disease would be of value in cheetahs (Acinonyx jubatus) as prevalence of CKD is relatively high in this species in captivity. Fifty-eight banked serum and plasma samples from seven adult cheetahs that died of CKD were analyzed for creatinine, urea, and SDMA. A marked increase in SDMA was noted on five of the tested cheetahs earlier than the rise of serum creatinine and urea (estimated 8-35 mo; mean 21...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28919689/beta-lactamase-antimicrobial-resistance-in-klebsiella-and-enterobacter-species-isolated-from-healthy-and-diarrheic-dogs-in-andhra-pradesh-india
#20
N Mohammad Sharif, B Sreedevi, R K Chaitanya, D Sreenivasulu
AIM: The aim of this study was to characterize beta-lactamase antimicrobial resistance in Klebsiella and Enterobacter species isolated from healthy and diarrheic dogs in Andhra Pradesh. MATERIALS AND METHODS: A total of 136 rectal swabs were collected from healthy (92) and diarrheic (44) dogs, bacteriological cultured for Klebsiella and Enterobacter growth and screened for beta-lactamase antimicrobial resistance phenotypically by disc diffusion method and genotypically by polymerase chain reaction targeting blaTEM, blaSHV, blaOXA, blaCTX-M Group 1, 2, blaAmpC, blaACC, and blaMOX genes...
August 2017: Veterinary World
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