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https://www.readbyqxmd.com/read/28805867/coumarin-containing-thermoresponsive-hyaluronic-acid-based-nanogels-as-delivery-systems-for-anticancer-chemotherapy
#1
Talitha F Stefanello, Benoit Couturaud, Anna Szarpak-Jankowska, David Fournier, Benoit Louage, Francielle P Garcia, Celso V Nakamura, Bruno G De Geest, Patrice Woisel, Boudewijn van der Sanden, Rachel Auzély-Velty
Multi-stimuli responsive nanogels based on biocompatible hydrophilic polymers have emerged as promising drug delivery systems to improve anticancer therapy with hydrophobic drugs, through increase of circulating-time in the bloodstream, tumor-targeting and reduction of systemic toxicity. This paper reports on the synthesis, characterization and biological perspectives of light- and thermoresponsive hyaluronic acid (HA)-based nanogels containing coumarin as the photocleavable group. Newly synthesized nanogels exhibited interesting features: formation by a temperature-triggered self-assembly process, successful incorporation of poorly water-soluble molecules, light-responsiveness as demonstrated by a significant shift in the critical aggregation temperature after light irradiation, efficient internalization by cancer cells overexpressing the CD44 receptor of HA, ability to circulate for a prolonged period of time in the bloodstream after intravenous injection in mice and considerable detection in tumor tissues...
August 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28803780/methylation-of-dna-ligase-1-by-g9a-glp-recruits-uhrf1-to-replicating-dna-and-regulates-dna-methylation
#2
Laure Ferry, Alexandra Fournier, Takeshi Tsusaka, Guillaume Adelmant, Tadahiro Shimazu, Shohei Matano, Olivier Kirsh, Rachel Amouroux, Naoshi Dohmae, Takehiro Suzuki, Guillaume J Filion, Wen Deng, Maud de Dieuleveult, Lauriane Fritsch, Srikanth Kudithipudi, Albert Jeltsch, Heinrich Leonhardt, Petra Hajkova, Jarrod A Marto, Kyohei Arita, Yoichi Shinkai, Pierre-Antoine Defossez
DNA methylation is an essential epigenetic mark in mammals that has to be re-established after each round of DNA replication. The protein UHRF1 is essential for this process; it has been proposed that the protein targets newly replicated DNA by cooperatively binding hemi-methylated DNA and H3K9me2/3, but this model leaves a number of questions unanswered. Here, we present evidence for a direct recruitment of UHRF1 by the replication machinery via DNA ligase 1 (LIG1). A histone H3K9-like mimic within LIG1 is methylated by G9a and GLP and, compared with H3K9me2/3, more avidly binds UHRF1...
August 4, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28801729/-plastic-reconstruction-of-external-genitalia-after-fournier-s-gangrene
#3
REVIEW
E Comploj, A Pycha
Fournier's gangrene is a rapidly progressing necrotizing fasciitis restricted to the perineal and genital regions. Although rare, it is an acute life-threatening disease, requiring rapid radical surgical debridement and antibiotic treatment, resulting in large soft tissue defects. Various reconstructive methods for defect coverage are applied to satisfactorily reconstitute functionality and esthetics.
August 11, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28801670/ectodomain-shedding-of-limbic-system-associated-membrane-protein-lsamp-by-adam-metallopeptidases-promotes-neurite-outgrowth-in-drg-neurons
#4
Ricardo L Sanz, Gino B Ferraro, Marie-Pier Girouard, Alyson E Fournier
IgLONs are members of the immunoglobulin superfamily of cell adhesion proteins implicated in the process of neuronal outgrowth, cell adhesion and subdomain target recognition. IgLONs form homophilic and heterophilic complexes on the cell surface that repress or promote growth depending on the neuronal population, the developmental stage and surface repertoire of IgLON family members. In the present study, we identified a metalloproteinase-dependent mechanism necessary to promote growth in embryonic dorsal root ganglion cells (DRGs)...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28799004/phase-ii-trial-of-laparoscopic-hyperthermic-intraperitoneal-chemoperfusion-for-peritoneal-carcinomatosis-or-positive-peritoneal-cytology-in-patients-with-gastric-adenocarcinoma
#5
Brian Badgwell, Mariela Blum, Prajnan Das, Jeannelyn Estrella, Xuemei Wang, Linus Ho, Keith Fournier, Richard Royal, Paul Mansfield, Jaffer Ajani
PURPOSE: The aim of this phase II study was to perform neoadjuvant hyperthermic intraperitoneal chemoperfusion (HIPEC) via a minimally invasive approach without cytoreduction for patients with gastric cancer and positive peritoneal cytology or low-volume peritoneal carcinomatosis. METHODS: Patients with gastric or gastroesophageal adenocarcinoma and positive peritoneal cytology or radiologically occult peritoneal carcinomatosis after systemic chemotherapy received laparoscopic HIPEC with mitomycin C 30 mg and cisplatin 200 mg...
August 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28798881/scrotal-abscess-drained-by-iatrogenic-urethral-fistula-in-an-adult-diabetic-male
#6
Marco Stizzo, Davide Arcaniolo, Carmelo Quattrone, Raffaele Balsamo, Marco Terribile, Celeste Manfredi, Vincenzo Mirone, Paolo Verze, Marco De Sio
A 46-year-old Caucasian male has been transferred to our urology department with a history of septic fever, uncompensated diabetes, pain, and scrotal swelling. On clinical examination, the left inguinal and scrotal area was swollen, tender, and painful; scrotal MR had been performed, showing the catheter tip in scrotal cavity and presence of gas. The case was diagnosed as scrotal abscess with urethroscrotal fistula. He was successfully treated with scrotal incision, drainage, catheter repositioning under fluoroscopic control, antibiotics, and insulin...
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/28798698/%C3%AE-catenin-knockdown-affects-mitochondrial-biogenesis-and-lipid-metabolism-in-breast-cancer-cells
#7
Daniele Vergara, Eleonora Stanca, Flora Guerra, Paola Priore, Antonio Gaballo, Julien Franck, Pasquale Simeone, Marco Trerotola, Stefania De Domenico, Isabelle Fournier, Cecilia Bucci, Michel Salzet, Anna M Giudetti, Michele Maffia
β-catenin plays an important role as regulatory hub in several cellular processes including cell adhesion, metabolism, and epithelial mesenchymal transition. This is mainly achieved by its dual role as structural component of cadherin-based adherens junctions, and as a key nuclear effector of the Wnt pathway. For this dual role, different classes of proteins are differentially regulated via β-catenin dependent mechanisms. Here, we applied a liquid chromatography-mass spectrometry (LC-MS/MS) approach to identify proteins modulated after β-catenin knockdown in the breast cancer cell line MCF-7...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28797355/increasing-prevalence-of-atrial-fibrillation-and-permanent-atrial-arrhythmias-in-congenital-heart-disease
#8
Fabien Labombarda, Robert Hamilton, Azadeh Shohoudi, Jamil Aboulhosn, Craig S Broberg, Marie A Chaix, Scott Cohen, Stephen Cook, Annie Dore, Susan M Fernandes, Anne Fournier, Joseph Kay, Laurent Macle, Blandine Mondésert, François-Pierre Mongeon, Alexander R Opotowsky, Anna Proietti, Lena Rivard, Jennifer Ting, Bernard Thibault, Ali Zaidi, Paul Khairy
BACKGROUND: Atrial arrhythmias are the most common complication encountered in the growing and aging population with congenital heart disease. OBJECTIVES: This study sought to assess the types and patterns of atrial arrhythmias, associated factors, and age-related trends. METHODS: A multicenter cohort study enrolled 482 patients with congenital heart disease and atrial arrhythmias, age 32.0 ± 18.0 years, 45.2% female, from 12 North American centers...
August 15, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28796292/exposure-to-low-environmental-concentrations-of-manganese-lead-and-cadmium-alters-the-serotonin-system-of-blue-mussels
#9
Marc Fraser, Marlène Fortier, Delphine Foucher, Pierre-Hervé Roumier, Pauline Brousseau, Michel Fournier, Céline Surette, Cathy Vaillancourt
Serotonin plays a crucial role in mussel survival and reproduction. Although serotonin system can be affected by metals, the effects of environmental concentration of metals, such as manganese (Mn), lead (Pd), and cadmium (Cd), have never been studied in blue mussels. This study aims to determine the effects of exposure to Mn, Pb or Cd on serotonin levels, monoamine oxidase (MAO) activity, and serotonin transporter (SERT) in the blue mussel, Mytilus edulis. Mussels were exposed in vivo to increasing and environmentally relevant doses of Mn (10-1000 nM; 0...
August 10, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28794887/-lactobacillus-timonensis-sp-nov-a-new-bacterial-species-isolated-from-the-human-gut
#10
P Afouda, P E Fournier, D Raoult, V Merhej
Here, we describe the main characteristics of 'Lactobacillus timonenis' sp. nov., strain Marseille-P3825(T) (CSUR=P3825), isolated from a stool sample of a healthy Beninese woman.
September 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28794883/description-of-arabia-massiliensis-gen-nov-sp-nov-gordonibacter-massiliensis-sp-nov-and-bacilliculturomica-massiliensis-gen-nov-sp-nov-isolated-from-a-faecal-specimen-of-a-50-year-old-saudi-bedouin-woman
#11
S I Traore, E I Azhar, M Yasir, F Bibi, P-E Fournier, A A Jiman-Fatani, J Delerce, F Cadoret, J-C Lagier, D Raoult
We report here the main characteristics of 'Arabia massiliensis' strain Marseille-P3078(T) gen. nov., sp. nov., 'Gordonibacter massiliensis' Marseille-P2775(T) sp. nov. and 'Bacilliculturomica massiliensis' strain Marseille-P3303 gen. nov., sp. nov. The culturomics approach combined with taxonogenomics was used to characterize these strains, which were all isolated from a faecal specimen of a 50-year-old Saudi Bedouin woman.
September 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28794176/molecular-tests-that-target-the-rtx-locus-do-not-distinguish-between-kingella-kingae-and-the-recently-described-kingella-negevensis-species
#12
Nawal El Houmami, Janek Bzdrenga, Guillaume André Durand, Philippe Minodier, Hervé Seligmann, Elsa Prudent, Sofiane Bakour, Stéphane Bonacorsi, Didier Raoult, Pablo Yagupsky, Pierre-Edouard Fournier
Kingella kingae is an important invasive pathogen in early childhood. The organism elaborates a RTX toxin presumably restricted to this species. Consequently, real-time PCR (qPCR) assays targeting the RTX locus have been developed in recent years and are gaining increasing use for the molecular diagnosis of K. kingae infections. However, this study shows that Kingella negevensis, a Kingella species newly identified in young children, harbors an identical Kingella RTX locus, raising the question whether K. negevensis could be misdiagnosed as K...
August 9, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28794062/high-quality-de-novo-genome-assembly-of-the-dekkera-bruxellensis-yeast-isolate-using-nanopore-minion-sequencing
#13
Téo Fournier, Jean-Sébastien Gounot, Kelle Freel, Corinne Cruaud, Arnaud Lemainque, Jean-Marc Aury, Patrick Wincker, Joseph Schacherer, Anne Friedrich
Genetic variation in natural populations represents the raw material for phenotypic diversity. Species-wide characterization of genetic variants is crucial to have a deeper insight into the genotype-phenotype relationship. With the advent of new sequencing strategies and more recently the release of long-read sequencing platforms, it is now possible to explore the genetic diversity of any non-model organisms, representing a fundamental resource for biological research. In the frame of population genomic surveys, a first step is to obtain the complete sequence and high quality assembly of a reference genome...
August 9, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28792564/-a-framework-to-support-action-in-population-mental-health
#14
Pascale Mantoura, Marie-Claude Roberge, Louise Fournier
In Quebec, like elsewhere in the world, we are witnessing a growing concern for the population's mental health and for the importance of concentrating efforts on prevention and promotion. In this context, public health actors are invited to adopt a leadership role in advancing mental health promotion and mental disorder prevention goals, and establish the required partnerships with actors from the health and social services and from other sectors who are indispensable to the population mental health agenda...
2017: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/28792191/comparison-of-vacuum-assisted-closure-therapy-and-debridement-with-primer-surgical-closure-for-fournier-s-gangrene-treatment-10-years-experience-of-a-single-centre
#15
Mustafa Ozan Horsanali, Utku Eser, Burcu O Horsanali, Omer Altas, Huseyin Eren
OBJECTIVE: Fournier's gangrene is a type of necrotizing soft tissue infection of the perineal, genital and perianal region that has a rapidly progressive and potentially fatal course. In the present study, our goal was to compare the patients submitted to surgical debridement for Fournier Gangrene with Vacuum-asisted Closure (VAC) and without VAC therapy after debridement. MATERIALS AND METHODS: We retrospectively analyzed 313 patients underwent surgical debridement for FG in our hospital...
August 8, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28791387/atelocollagen-mediated-in-vivo-sirna-transfection-in-ovarian-carcinoma-is-influenced-by-tumor-site-sirna-target-and-administration-route
#16
Matthieu Meryet-Figuière, Charlotte Lecerf, Emilie Varin, Jean-Luc Coll, Marie-Hélène Louis, Soizic Dutoit, Florence Giffard, Cécile Blanc-Fournier, Siham Hedir, Nicolas Vigneron, Emilie Brotin, Laurent Pelletier, Véronique Josserand, Christophe Denoyelle, Laurent Poulain
Ovarian cancer is the leading cause of death from gynecological malignancies worldwide, and innate or acquired chemoresistance of ovarian cancer cells is the major cause of therapeutic failure. It has been demonstrated that the concomitant inhibition of Bcl-xL and Mcl-1 anti-apoptotic activities is able to trigger apoptosis in chemoresistant ovarian cancer cells. In this context, siRNA-mediated Bcl‑xL and Mcl-1 inhibition constitutes an appealing strategy by which to eliminate chemoresistant cancer cells...
August 4, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28791026/decrease-of-markers-related-to-bone-erosion-in-serum-of-patients-with-musculoskeletal-disorders-after-serial-low-dose-radon-spa-therapy
#17
Aljona Cucu, Kateryna Shreder, Daniela Kraft, Paul Friedrich Rühle, Gerhart Klein, Gerhard Thiel, Benjamin Frey, Udo S Gaipl, Claudia Fournier
Musculoskeletal disorders (MSDs) are the most frequent cause of disability in Europe. Reduced mobility and quality of life of the patients are often associated with pain due to chronic inflammation. The inflammatory process, accompanied by a destruction of the cartilage and bone tissue, is discussed as a result of (A) the infiltration of immune cells into the joints, (B) an altered homeostasis of the joint cavity (synovium) with a critical role of bone remodeling cells, and (C) release of inflammatory factors including adipokines in the arthritic joint...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28772350/claudin-1-mir-122-and-apolipoprotein-e-transduction-improves-the-permissivity-of-snu-182-snu-398-and-snu-449-hepatoma-cells-to-hepatitis-c-virus
#18
Carole Fournier, Thomas Walter Hoffmann, Virginie Morel, Véronique Descamps, Jean Dubuisson, Etienne Brochot, Catherine Francois, Gilles Duverlie, Sandrine Castelain, Francois Helle
Hepatitis C virus (HCV) is a human hepatotropic virus but many hepatoma cell lines are not permissive to this virus. In a previous study, we observed that SNU-182, SNU-398 and SNU-449 hepatoma cell lines were non-permissive to HCV. In order to understand the non-permissivity, we evaluated the ability of each cell line to support the different steps of HCV life cycle (entry, replication and production of infectious particles). Using retroviral pseudoparticles pseudotyped with HCV envelope proteins and recombinant HCV produced in cell culture, we observed that low level or absence of claudin-1 expression limited the viral entry process in SNU-182 and SNU-398 cells, respectively...
August 3, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28768426/necrotising-fasciitis-in-a-patient-treated-with-folfiri-aflibercept-for-colorectal-cancer-a-case-report
#19
A Gonzaga-López, J Muñoz-Rodriguez, A Ruiz-Casado
Anti-angiogenics have become an important part of the treatment of several types of tumours such as ovarian, breast, lung and colorectal cancer. Necrotising fasciitis has been reported with bevacizumab but no cases have been reported with aflibercept, ramucirumab or regorafenib in patients with colorectal cancer. Necrotising fasciitis is a rare complication affecting one in 5000 bevacizumab users. We report the case of a 64-year-old man with stage IV rectosigmoid cancer under treatment with folinic acid, fluorouracil and irinotecan (FOLFIRI) and aflibercept, who developed a Fournier's gangrene...
August 3, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28762979/in-house-time-resolved-photocrystallography-on-the-millisecond-timescale-using-a-gated-x-ray-hybrid-pixel-area-detector
#20
Nicolas Casaretto, Dominik Schaniel, Paul Alle, Emmanuel Wenger, Pascal Parois, Bertrand Fournier, El Eulmi Bendeif, Cyril Palin, Sébastien Pillet
With the remarkable progress of accelerator-based X-ray sources in terms of intensity and brightness, the investigation of structural dynamics from time-resolved X-ray diffraction methods is becoming widespread in chemistry, biochemistry and materials science applications. Diffraction patterns can now be measured down to the femtosecond time-scale using X-ray free electron lasers or table-top laser plasma X-ray sources. On the other hand, the recent developments in photon counting X-ray area detectors offer new opportunities for time-resolved crystallography...
August 1, 2017: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
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