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https://www.readbyqxmd.com/read/29350794/the-role-of-electrodiagnosis-with-long-exercise-test-in-mcardle-disease
#1
Claudio Semplicini, Marianne Hézode-Arzel, Pascal Laforêt, Anthony Béhin, Sarah Leonard-Louis, Jean-Yves Hogrel, François Petit, Bruno Eymard, Tanya Stojkovic, Emmanuel Fournier
INTRODUCTION: We evaluated the role of an electrodiagnsotic provocative test (long exercise test, LET) in McArdle disease. METHODS: Twenty-five McArdle patients and two control groups underwent an electrodiagnsotic protocol with LET, consisting of recording the compound muscle action potential (CMAP) before and after 5 minutes of isometric contraction. RESULTS: LET disclosed a post-exercise decrease in CMAP amplitude in 23/25 McArdle patients...
January 19, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29347262/dynamics-of-a-bilayer-membrane-coupled-to-a-two-dimensional-cytoskeleton-scale-transfers-of-membrane-deformations
#2
Ryuichi Okamoto, Shigeyuki Komura, Jean-Baptiste Fournier
We theoretically investigate the dynamics of a floating lipid bilayer membrane coupled with a two-dimensional cytoskeleton network, taking into account explicitly the intermonolayer friction, the discrete lattice structure of the cytoskeleton, and its prestress. The lattice structure breaks lateral continuous translational symmetry and couples Fourier modes with different wave vectors. It is shown that within a short time interval a long-wavelength deformation excites a collection of modes with wavelengths shorter than the lattice spacing...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29341017/molecular-magnetic-resonance-imaging-mmri
#3
Maxime Gauberti, Antoine P Fournier, Denis Vivien, Sara Martinez de Lizarrondo
Molecular magnetic resonance imaging (mMRI) enables the detection of a protein of interest in vivo, in a noninvasive manner. The general concept of mMRI is to target a contrast agent to a protein of interest, and to perform a contrast-sensitive MRI sequence. Typically, contrast agents are made of a "contrastophore" (the part of the construct responsible for the contrast on the images) and a targeting moiety ("pharmacophore"). Recently, the development of a new family of contrastophore carrying a high payload of iron oxide (micro-sized particles of iron oxide, MPIO) has led to a dramatic increase in the sensitivity of mMRI...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29335550/the-peg-responding-desiccome-of-the-alder-microsymbiont-frankia-alni
#4
Kais Ghedira, Emna Harigua-Souiai, Cherif Ben Hamda, Pascale Fournier, Petar Pujic, Sihem Guesmi, Ikram Guizani, Guylaine Miotello, Jean Armengaud, Philippe Normand, Haïtham Sghaier
Actinorhizal plants are ecologically and economically important. Symbiosis with nitrogen-fixing bacteria allows these woody dicotyledonous plants to colonise soils under nitrogen deficiency, water-stress or other extreme conditions. However, proteins involved in xerotolerance of symbiotic microorganisms have yet to be identified. Here we characterise the polyethylene glycol (PEG)-responding desiccome from the most geographically widespread Gram-positive nitrogen-fixing plant symbiont, Frankia alni, by next-generation proteomics, taking advantage of a Q-Exactive HF tandem mass spectrometer equipped with an ultra-high-field Orbitrap analyser...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29328980/consequence-of-intraventricular-hemorrhage-on-neurovascular-coupling-evoked-by-speech-syllables-in-preterm-neonates
#5
Mahdi Mahmoudzadeh, Ghislaine Dehaene-Lambertz, Guy Kongolo, Marc Fournier, Sabrina Goudjil, Fabrice Wallois
Intraventricular Hemorrhage (IVH) is the leading cause of neurological and cognitive impairment in preterm neonates with an incidence that increases with increasing prematurity. In the present study, we tested how preterm neonates with IVH react to external stimulation (i.e. speech syllables). We compared their neural responses measured by electroencephalography (EEG), and hemodynamic responses measured by functional near-infrared spectroscopy (fNIRS), with those of healthy preterms. A neural response to syllables was observed in these infants, but did not induce a vascular response in contrast with healthy neonates...
January 5, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29327816/brain-cortex-microglia-derived-exosomes-novel-nanoparticles-for-glioma-therapy
#6
Adriana-Natalia Murgoci, Dasa Cizkova, Petra Majerova, Eva Petrovova, Lubomir Medvecky, Isabelle Fournier, Michel Salzet
The function and integrity of nervous system require interactive exchanges among neurons and glial cells. Exosomes and other extracellular vesicles (EVs) are emerging as a key mediator of intercellular communication, capable to transfer nucleic acids, proteins and lipids, influencing numerous functional and pathological aspects of both donor and recipient cells. The immune response mediated by microglia derived exosomes are most prominently involved in the spread of neuroinflammation, neurodegenerative disorders and brain cancer...
January 12, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29327509/proteomic-expression-profile-of-injured-rat-peripheral-nerves-revealed-biological-networks-and-processes-associated-with-nerve-regeneration
#7
D Vergara, A Romano, E Stanca, V La Pesa, A L Aloisi, S De Domenico, J Franck, I Cicalini, A M Giudetti, E Storelli, D Pieragostino, I Fournier, A Sannino, M Salzet, F Cerri, A Quattrini, M Maffia
Peripheral nerve regeneration is regulated through the coordinated spatio-temporal activation of multiple cellular pathways. In this work, an integrated proteomics and bioinformatics approach was employed to identify differentially expressed proteins at the injury-site of rat sciatic nerve at 20 days after damage. By a label-free liquid chromatography mass-spectrometry (LC-MS/MS) approach, we identified 201 differentially proteins that were assigned to specific canonical and disease and function pathways. These include proteins involved in cytoskeleton signaling and remodeling, acute phase response, and cellular metabolism...
January 12, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29327456/discovery-and-characterization-of-cd12681-a-potent-ror%C3%AE-inverse-agonist-preclinical-candidate-for-the-topical-treatment-of-psoriasis
#8
Gilles Ouvry, Nicolas Atrux-Tallau, Franck Bihl, Aline Bondu, Claire Bouix-Peter, Isabelle Carlavan, Olivier Christin, Marie-Josée Cuadrado, Claire Defoin-Platel, Sophie Deret, Denis Duvert, Christophe Feret, Mathieu Forissier, Jean-François Fournier, David Froude, Fériel Hacini-Rachinel, Craig Steven Harris, Catherine Hervouet, Hélène Huguet, Guillaume Lafitte, Anne-Pascale Luzy, Branislav Musicki, Danielle Orfila, Benjamin Ozello, Coralie Pascau, Jonathan Pascau, Véronique Parnet, Guillaume Peluchon, Romain Pierre, David Piwnica, Catherine Raffin, Patricia Rossio, Delphine Spiesse, Nathalie Taquet, Etienne Thoreau, Rodolphe Vatinel, Emmanuel Vial, Laurent François Hennequin
With possible implications in multiple autoimmune diseases, the retinoic acid receptor-related orphan receptor RORγ has become a very sought-after target in the pharmaceutical industry. Herein are described the efforts to identify a potent RORγ inverse agonist compatible with topical application for the treatment of skin diseases. These efforts culminated with the discovery of CD12681 (compound 14; N-(2,4-dimethylphenyl)-N-isobutyl-2-oxo-1-((tetrahydro-2H-pyran-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-5-sulfonamide), a potent inverse agonist with in vivo activity in an IL-23 induced skin inflammation model in mouse...
January 12, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29326224/draft-genome-sequence-of-megamonas-funiformis-strain-marseille-p3344-isolated-from-a-human-fecal-microbiota
#9
Mossaab Maaloum, Awa Diop, Sokhna Ndongo, Thi-Tien Nguyen, Frederic Cadoret, Didier Raoult, Pierre-Edouard Fournier
In this article, we present the draft genome sequence of Megamonas funiformis strain Marseille-P3344, isolated from a human fecal sample. The genome described here is composed of 2,464,704 nucleotides, with 2,230 protein-coding genes and 76 RNA genes.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29320539/the-impact-of-electronic-consultation-on-a-canadian-tertiary-care-pediatric-specialty-referral-system-a-prospective-single-center-observational-study
#10
Lillian Lai, Clare Liddy, Erin Keely, Amir Afkham, Julia Kurzawa, Nishard Abdeen, Tobey Audcent, Matthew Bromwich, Jason Brophy, Sasha Carsen, Annick Fournier, Leigh Fraser-Roberts, Hazen Gandy, Charles Hui, Donna Johnston, Kathryn Keely, Ken Kontio, Christine Lamontagne, Nathalie Major, Michael O'Connor, Dhenuka Radhakrishnan, Joe Reisman, Marjorie Robb, Lindy Samson, Erick Sell, William Splinter, Judy van Stralen, Sunita Venkateswaran, Kimmo Murto
BACKGROUND: Champlain BASE™ (Building Access to Specialists through eConsultation) is a web-based asynchronous electronic communication service that allows primary-care- practitioners (PCPs) to submit "elective" clinical questions to a specialist. For adults, PCPs have reported improved access and timeliness to specialist advice, averted face-to-face specialist referrals in up to 40% of cases and high provider satisfaction. OBJECTIVE: To determine whether the expansion of eConsult to a pediatric setting would result in similar measures of improved healthcare system process and high provider acceptance reported in adults...
2018: PloS One
https://www.readbyqxmd.com/read/29317841/obesity-in-mexico-prevalence-comorbidities-associations-with-patient-outcomes-and-treatment-experiences
#11
Marco D DiBonaventura, Henrik Meincke, Agathe Le Lay, Janine Fournier, Erik Bakker, Allison Ehrenreich
Objective: The goal of this study is to investigate obesity and its concomitant effects including the prevalence of comorbidities, its association with patient-reported outcomes and costs, and weight loss strategies in a sample of Mexican adults. Methods: Mexican adults (N=2,511) were recruited from a combination of Internet panels and street intercepts using a random-stratified sampling framework, with strata defined by age and sex, so that they represent the population...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29317363/spheno-orbital-meningiomas-surgery-multicenter-management-study-for-complex-extensive-tumors
#12
Louis-Marie Terrier, Florian Bernard, Henri-Dominique Fournier, Xavier Morandi, Stéphane Velut, Pierre-Louis Hénaux, Aymeric Amelot, Patrick François
BACKGROUND: Spheno-orbital meningiomas (SOMs) are complex tumors involving the sphenoid wing, the orbit, and sometimes the cavernous sinus with bone hyperostosis and sheet-like dural involvement. Optimal removal, proptosis cure and visual preservation remain a challenge. OBJECTIVE: To study the management of surgically treated SOMs METHODS: The clinical records of 130 consecutive patients undergoing surgery for SOMs were retrospectively collected in a database during a 20-year period to analyze symptoms, surgical technique, clinical outcome, and follow-up...
January 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29316869/fournier-s-gangrene-a-rare-manifestation-of-chikungunya-fever
#13
Apoorv Goel, Shalabh Gupta, Ayush Agarwal, Nitin Shiwach, Vishal Chawda, Tripta S Bhagat
No abstract text is available yet for this article.
January 2018: Tropical Doctor
https://www.readbyqxmd.com/read/29316153/internal-hernia-following-laparoscopic-low-anterior-resection-a-serious-complication-often-misdiagnosed
#14
François Rouleau-Fournier, Sebastien Drolet, Alexandre Bouchard, Philippe Bouchard
No abstract text is available yet for this article.
January 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29308669/an-open-label-study-of-a-novel-immunosuppression-intervention-for-the-treatment-of-amyotrophic-lateral-sclerosis
#15
Christina N Fournier, David Schoenfeld, James D Berry, Merit E Cudkowicz, James Chan, Colin Quinn, Robert H Brown, Johnny S Salameh, Malu G Tansey, David R Beers, Stanley H Appel, Jonathan D Glass
Neuroinflammation is increasingly tied to disease progression in amyotrophic lateral sclerosis (ALS). Participants in the first-in-human trial of intra-spinal allogeneic stem cell therapy for ALS received immunosuppression, and one participant saw dramatic improvement across multiple outcome measures. The primary objective of this study (NCT01884571) was to assess the rate of clinical response to the same immunosuppressive regimen using basiliximab, tacrolimus, mycophenolate, and prednisone in people with ALS...
January 8, 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29308430/sex-specific-consequences-of-neonatal-stress-on-cardio-respiratory-inhibition-following-laryngeal-stimulation-in-rat-pups
#16
Cécile Baldy, Simon Chamberland, Stéphanie Fournier, Richard Kinkead
The presence of liquid near the larynx of immature mammals triggers prolonged apneas with significant O2 desaturations and bradycardias. When excessive, this reflex (the laryngeal chemoreflex; LCR) can be fatal. Our understanding of the origins of abnormal LCR are limited; however, perinatal stress and male sex are risk factors for cardio-respiratory failure in infants. Because exposure to stress during early life has deleterious and sex-specific consequences on brain development it is plausible that respiratory reflexes are vulnerable to neuroendocrine dysfunction...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29307737/detection-of-carbapenemase-activity-in-pseudomonas-aeruginosa-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-maldi-tof-ms
#17
G Miltgen, P Plésiat, A Mille, P Chatelain, D Fournier
A new MALDI-TOF MS imipenem hydrolysis assay was developed to optimize detection of carbapenemase-producing strains of Pseudomonas aeruginosa. The method correctly discriminated carbapenemase producers (n=74) from non-producers (n=95) in 99.4% of cases, and successfully detected 100% GES-5 strains (n=5).
January 4, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29304851/development-of-the-excitation-contraction-coupling-machinery-and-its-relation-to-myofibrillogenesis-in-human-ipsc-derived-skeletal-myocytes
#18
Jeanne Lainé, Gunnar Skoglund, Emmanuel Fournier, Nacira Tabti
BACKGROUND: Human induced pluripotent stem cells-derived myogenic progenitors develop functional and ultrastructural features typical of skeletal muscle when differentiated in culture. Besides disease-modeling, such a system can be used to clarify basic aspects of human skeletal muscle development. In the present study, we focus on the development of the excitation-contraction (E-C) coupling, a process that is essential both in muscle physiology and as a tool to differentiate between the skeletal and cardiac muscle...
January 5, 2018: Skeletal Muscle
https://www.readbyqxmd.com/read/29300857/modelling-interaction-dynamics-between-two-foliar-pathogens-in-wheat-a-multi-scale-approach
#19
Guillaume Garin, Christophe Pradal, Christian Fournier, David Claessen, Vianney Houlès, Corinne Robert
Background and Aims: Disease models can improve our understanding of dynamic interactions in pathosystems and thus support the design of innovative and sustainable strategies of crop protections. However, most epidemiological models focus on a single type of pathogen, ignoring the interactions between different parasites competing on the same host and how they are impacted by properties of the canopy. This study presents a new model of a disease complex coupling two wheat fungal diseases, caused by Zymoseptoria tritici (septoria) and Puccinia triticina (brown rust), respectively, combined with a functional-structural plant model of wheat...
December 29, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29299361/preoperative-accuracy-of-gastric-cancer-staging-in-patient-selection-for-preoperative-therapy-race-may-affect-accuracy-of-endoscopic-ultrasonography
#20
Naruhiko Ikoma, Jeffrey H Lee, Manoop S Bhutani, William A Ross, Brian Weston, Yi-Ju Chiang, Mariela A Blum, Tara Sagebiel, Catherine E Devine, Aurelio Matamoros, Keith Fournier, Paul Mansfield, Jaffer A Ajani, Brian D Badgwell
Background: Over the last 15 years, large randomized controlled studies have validated the benefit of preoperative therapy for patients with resectable gastric cancer. Computed tomography (CT) and endoscopic ultrasonography (EUS) are commonly used to select patients for preoperative treatment, but studies of preoperative staging accuracy that focus on patient selection for preoperative therapy are rare; therefore, whether CT or EUS can reliably identify patients eligible for preoperative therapy is still unclear...
December 2017: Journal of Gastrointestinal Oncology
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