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https://www.readbyqxmd.com/read/28918174/14-3-3-adaptor-protein-protein-interactions-as-therapeutic-targets-for-cns-diseases
#1
REVIEW
Andrew Kaplan, Christian Ottmann, Alyson E Fournier
14-3-3sare a family of ubiquitously expressed adaptor proteins that regulate hundreds of functionally diverse 'client proteins.' In humans, there are seven isoforms with conserved structure and function. 14-3-3s typically bind to client proteins at phosphorylated serine/threonine motifs via a linear binding groove. Binding can have a variety of effects on the stability, activity and/or localization of the client protein. 14-3-3s are generating significant interest as potential drug targets for their involvement in cellular homeostasis and disease...
September 13, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28915487/genetic-backgrounds-and-hidden-trait-complexity-in-natural-populations
#2
REVIEW
Téo Fournier, Joseph Schacherer
Dissecting the genetic basis of natural phenotypic variation is a major goal in biology. We know that most traits are strongly heritable. However, their genetic architecture is a long-standing question, which is unfortunately confounded by the lack of complete knowledge of the genetic components as well as their phenotypic effect in a specific genetic background. Many genetic variants are known to affect phenotypes but the same functional variant can have a different effect on the phenotype in different individuals of the same species...
September 12, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28914060/nuclear-spin-symmetry-conservation-in-1-h2-16-o-investigated-by-direct-absorption-ftir-spectroscopy-of-water-vapor-cooled-down-in-supersonic-expansion
#3
Robert Georges, Xavier Michaut, Audrey Moudens, Manuel Goubet, Olivier Pirali, Pascale Soulard, Pierre Asselin, Therese R Huet, Pascale Roy, Martin Fournier, Andrey A Vigasin
We report the results of an experimental study related to the relaxation of the nuclear spin isomers of the water molecule in a supersonic expansion. Rovibrational lines of both ortho- and para- spin isomers were recorded in the spectral range of H2O stretching vibrations around 3700 cm(-1) using FTIR direct absorption. Water vapor seeded either in argon, helium, oxygen or in a mixture of oxygen and argon was expanded into vacuum through a slit nozzle. Partial water vapor pressure in the mixture varied in a wide range from 1...
September 15, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28912952/noncontiguous-finished-genome-sequences-and-descriptions-of-paenibacillus-bouchesdurhonensis-paenibacillus-rubinfantis-paenibacillus-senegalimassiliensis-and-paenibacillus-tuaregi-identified-by-culturomics
#4
T-P-T Pham, M Tidjani Alou, S I Traore, S Brah, B Ali Diallo, A Diallo, C Sokhna, E Baptiste, A Levasseur, P-E Fournier, F Cadoret, D Raoult
Microbial culturomics represents a completely new approach to investigate microbial diversity by using different optimized culture conditions, mass spectrometry, genome sequencing and annotation and phenotypic description that allow for an extensive characterization of new species and the study of the human microbiome. Here we present four new species within the genus Paenibacillus: 'Paenibacillus bouchesdurhonensis' strain Marseille-P3071(T), 'Paenibacillus rubinfantis' strain MT18(T), 'Paenibacillus senegalimassiliensis' strain SIT18(T) and 'Paenibacillus tuaregi' strain Marseille-P2472(T), which are all facultatively aerobic and Gram-positive bacilli...
November 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28911224/total-synthesis-of-unsymmetrically-oxidized-nuphar-thioalkaloids-via-copper-catalyzed-thiolane-assembly
#5
Jacob J Lacharity, Jeremy Fournier, Ping Lu, Artur K Mailyan, Aaron T Herrmann, Armen Zakarian
An asymmetric total synthesis of (+)-6-hydroxythiobinupharidine (1b) and (-)-6-Hydroxythionuphlutine (2b), a set of hemi-aminal containing dimeric sesquiterpenes isolated from yellow water lilies of the Nuphar genus, is described. The central bis-spirocyclic thiolane was forged through the Stevens rearrangement of a sulfonium ylide, generated in-situ from the coupling of a copper carbenoid with a spirocyclic thietane. This strategy diverges both from the proposed biosynthesis1 and previous syntheses of this family of alkaloids,2,3 all of which employ dimerization of symmetric monomers to form the aforementioned central thiolane...
September 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28905878/detecting-splicing-patterns-in-genes-involved-in-hereditary-breast-and-ovarian-cancer
#6
Grégoire Davy, Antoine Rousselin, Nicolas Goardon, Laurent Castéra, Valentin Harter, Angelina Legros, Etienne Muller, Robin Fouillet, Baptiste Brault, Anna S Smirnova, Fréderic Lemoine, Pierre de la Grange, Marine Guillaud-Bataille, Virginie Caux-Moncoutier, Claude Houdayer, Françoise Bonnet, Cécile Blanc-Fournier, Pascaline Gaildrat, Thierry Frebourg, Alexandra Martins, Dominique Vaur, Sophie Krieger
Interpretation of variants of unknown significance (VUS) is a major challenge for laboratories performing molecular diagnosis of hereditary breast and ovarian cancer (HBOC), especially considering that many genes are now known to be involved in this syndrome. One important way these VUS can have a functional impact is through their effects on RNA splicing. Here we present a custom RNA-Seq assay plus bioinformatics and biostatistics pipeline to analyse specifically alternative and abnormal splicing junctions in 11 targeted HBOC genes...
October 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28900129/multiple-p450s-and-variation-in-neuronal-genes-underpins-the-response-to-the-insecticide-imidacloprid-in-a-population-of-drosophila-melanogaster
#7
Shane Denecke, Roberto Fusetto, Felipe Martelli, Alex Giang, Paul Battlay, Alexandre Fournier-Level, Richard A O' Hair, Philip Batterham
Insecticide resistance is an economically important example of evolution in response to intense selection pressure. Here, the genetics of resistance to the neonicotinoid insecticide imidacloprid is explored using the Drosophila Genetic Reference Panel, a collection of inbred Drosophila melanogaster genotypes derived from a single population in North Carolina. Imidacloprid resistance varied substantially among genotypes, and more resistant genotypes tended to show increased capacity to metabolize and excrete imidacloprid...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28898157/intravenous-immunoglobulin-as-adjunctive-treatment-for-fournier-s-gangrene
#8
Oliver Sanders, Edward Gilbert-Kawai, Rajnish Saha
No abstract text is available yet for this article.
September 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28895201/long-term-kidney-transplant-survival-in-patients-with-continent-urinary-diversion
#9
Romain Fournier, Ricardo Codas-Duarte, Theresa Daily, Xavier Martin, Lionel Badet, Hakim Fassi-Fehri
OBJECTIVES: To report the long-term survival of transplanted kidneys in patients with a continent urinary diversion. METHODS: Between January 1987 and July 2015, 16 patients with a median age of 37 years (range 21-63 years) underwent kidney transplantation on a continent urinary diversion. A total of 14 patients presented irreversible dysfunction of the lower urinary tract, and two patients had required radical cystectomy because of bladder cancer. All continent urinary diversions were carried out before the transplantation...
September 11, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28894879/erratum-to-simple-scoring-system-for-prediction-of-mortality-in-fournier-s-gangrene
#10
A Erdoğan, I Aydoğan, K Şenol, E M Üçkan, Ş Ersöz, M Tez
No abstract text is available yet for this article.
September 11, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28894636/fournier-s-gangrene-a-review-and-outcome-comparison-from-2009-to-2016
#11
REVIEW
Mark Ferretti, Akhil A Saji, John Phillips
Objective: The outcome of Fournier's gangrene (FG) may be affected by comorbidities, demographics, and choice of treatment modality. We sought to evaluate our institution's management protocol of FG measured by mortality rate (MR) and length of hospital stay (LHS) in a retrospective cohort study. Approach: A database of 20 FG cases at our institution throughout the 2009-2016 study period was assembled by a retrospective review of medical records. A Fournier's Gangrene Severity Index Score (FGSIS) was calculated for each case...
September 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28893950/the-taf10-containing-tfiid-and-saga-transcriptional-complexes-are-dispensable-for-early-somitogenesis-in-the-mouse-embryo
#12
Paul Bardot, Stéphane D Vincent, Marjorie Fournier, Alexis Hubaud, Mathilde Joint, László Tora, Olivier Pourquié
During development, tightly regulated gene expression programs control cell fate and patterning. A key regulatory step in eukaryotic transcription is the assembly of the pre-initiation complex (PIC) at promoters. The PIC assembly has mainly been studied in vitro, and little is known about its composition during development. In vitro data suggests that TFIID is the general transcription factor that nucleates PIC formation at promoters. Here we show that TAF10, a subunit of TFIID and of the transcriptional co-activator SAGA, is required for the assembly of these complexes in the mouse embryo...
September 11, 2017: Development
https://www.readbyqxmd.com/read/28890998/neurodegenerative-cerebrospinal-fluid-biomarkers-tau-and-amyloid-beta-predict-functional-quality-of-life-and-neuropsychological-outcomes-after-aneurysmal-subarachnoid-hemorrhage
#13
Holger Joswig, Wolfgang Korte, Severin Früh, Lorenz Epprecht, Gerhard Hildebrandt, Jean-Yves Fournier, Martin Nikolaus Stienen
Cerebrospinal fluid (CSF) biomarkers might be useful in predicting outcome after aneurysmal subarachnoid hemorrhage (aSAH). It was the aim to determine whether tau and amyloid beta CSF concentrations predict functional, health-related quality of life (hrQoL), and neuropsychological outcomes after aSAH. Ventricular CSF was obtained from n = 24 aSAH patients at admission (D0), day 2 (D2), and day 6 (D6). CSF total (t)Tau, phosphorylated (p)Tau(181P), and amyloid beta(1-40 and 1-42) (Aβ40/Aβ42) levels were compared between patients with favorable and unfavorable functional (modified Rankin Scale (mRS)), hrQoL (Euro-Qol (EQ-5D)), and neuropsychological outcomes at 3 (3 m) and 12 months (12 m)...
September 10, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28888770/test-retest-reliability-of-cerebral-blood-flow-in-healthy-individuals-using-arterial-spin-labeling-findings-from-the-embarc-study
#14
Jorge R C Almeida, Tsafrir Greenberg, Hanzhang Lu, Henry W Chase, Jay Fournier, Crystal M Cooper, Thilo Deckersbach, Phil Adams, Thomas Carmody, Mauricio Fava, Benji Kurian, Patrick J McGrath, Melvin McInnis, Maria A Oquendo, Ramin Parsey, Myrna Weissman, Madhukar Trivedi, Mary L Phillips
INTRODUCTION: Previous investigations of test-retest reliability of cerebral blood flow (CBF) at rest measured with pseudo-continuous Arterial Spin Labeling (pCASL) demonstrated good reliability, but are limited by the use of similar scanner platforms. In the present study we examined test-retest reliability of CBF in regions implicated in emotion and the default mode network. MATERIAL AND METHODS: We measured absolute and relative CBF at rest in thirty-one healthy subjects in two scan sessions, one week apart, at four different sites and three different scan platforms...
September 6, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28887847/fournier-s-gangrene-in-a-man-on-empagliflozin-for-treatment-of-type-2-diabetes
#15
S Kumar, A J Costello, P G Colman
Use of sodium glucose co-transporter 2 (SLGT2) inhibitors has been associated with an increased risk of genital infections secondary to increased glycosuria [1]. Our report highlights a case of Fournier's gangrene, the most severe and potentially fatal type of genital infection, which was preceded by multiple episodes of thrush in a man treated with empagliflozin for Type 2 diabetes. This article is protected by copyright. All rights reserved.
September 8, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28887729/intestinal-microbiome-gut-brain-axis-and-irritable-bowel-syndrome
#16
REVIEW
Gabriele Moser, Camille Fournier, Johannes Peter
Psychological comorbidity is highly present in irritable bowel syndrome (IBS). Recent research points to a role of intestinal microbiota in visceral hypersensitivity, anxiety, and depression. Increased disease reactivity to psychological stress has been described too. A few clinical studies have attempted to identify features of dysbiosis in IBS. While animal studies revealed strong associations between stress and gut microbiota, studies in humans are rare. This review covers the most important studies on intestinal microbial correlates of psychological and clinical features in IBS, including stress, anxiety, and depression...
September 8, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28885966/the-effect-of-anthropomorphic-test-device-lower-leg-surrogate-selection-on-impact-mitigating-system-evaluation-in-low-and-high-rate-loading-conditions
#17
Cheryl E Quenneville, Ed Fournier, Nicholas Shewchenko
INTRODUCTION: The lower legs are at risk of substantial injury during events such as frontal automotive crashes and antivehicular mine blasts. Loading to occupants can be assessed using an instrumented anthropomorphic test device (ATD), whose measurements can be compared to established injury criteria. NATO's AEP-55 STANAG 4569 recognizes two surrogates for lower leg injury assessments from impacts with intruding floor pans resulting from underbelly blast loads; (1) the rigid Hybrid III instrumented lower leg, and; (2) the compliant MILitary Lower eXtremity (MIL-LX)...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28885117/the-interperiosteodural-concept-applied-to-the-jugular-foramen-and-its-compartmentalization
#18
Florian Bernard, Ilyess Zemmoura, Jean Philippe Cottier, Henri-Dominique Fournier, Louis-Marie Terrier, Stéphane Velut
OBJECTIVE The dura mater is made of 2 layers: the endosteal layer (outer layer), which is firmly attached to the bone, and the meningeal layer (inner layer), which directly covers the brain and spinal cord. These 2 dural layers join together in most parts of the skull base and cranial convexity, and separate into the orbital and perisellar compartments or into the spinal epidural space to form the extradural neural axis compartment (EDNAC). The EDNAC contains fat and/or venous blood. The aim of this dissection study was to anatomically verify the concept of the EDNAC by focusing on the dural layers surrounding the jugular foramen area...
September 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28882512/epidemiology-of-babesia-anaplasma-and-trypanosoma-species-using-a-new-expanded-reverse-line-blot-hybridization-assay
#19
Martina Soledad Paoletta, Ludmila López Arias, Sofía de la Fournière, Eliana Carolina Guillemi, Carlos Luciani, Néstor Fabián Sarmiento, Juan Mosqueda, Marisa Diana Farber, Silvina Elizabeth Wilkowsky
Vector-borne hemoparasitic infections are a major problem that affects livestock industries worldwide, particularly in tropical and subtropical regions. In this work, a reverse line blot (RLB) hybridization assay was developed for the simultaneous detection and identification of Anaplasma, Babesia and bovine trypanosomes, encompassing in this way the most relevant hemoparasites that affect cattle. A total of 186 bovine blood samples collected from two different ecoepidemiological regions of northeast Argentina, with and without tick control, were analyzed with this new RLB...
September 1, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28873433/overview-of-preventive-practices-provided-by-primary-care-physicians-a-cross-sectional-study-in-switzerland-and-france
#20
Paul Sebo, Hubert Maisonneuve, Bernard Cerutti, Jean-Pascal Fournier, Nicolas Senn, Cédric Rat, Dagmar M Haller
BACKGROUND: A range of preventive practices are recommended to reduce the burden of chronic diseases. The aim of our study was to describe the preventive practices of French-speaking primary care physicians. METHODS: A cross-sectional survey was conducted in 2015 in a randomly selected sample of 1100 primary care physicians (700 in Switzerland, 400 in France). The physicians were asked how often they performed the following recommended preventive practices: blood pressure, weight and height measurements, screening for dyslipidemia, screening for alcohol use and brief intervention, screening for smoking (and brief advice for smokers), colon and prostate cancer screening, and influenza immunization...
2017: PloS One
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