Rong-Xin Zhang, Xiao-Jun Wu, De-Sen Wan, Jun-Zhong Lin, Pei-Rong Ding, Le-En Liao, Jian Lei, Zhen-Hai Lu, Li-Ren Li, Gong Chen, Ling-Heng Kong, Fu-Long Wang, Jian Zhang, Wen-Hua Fan, Wu Jiang, Wen-Hao Zhou, Cong Li, Yuan Li, Xue-Ying Li, Jian-Hong Peng, Zhi-Zhong Pan
BACKGROUND: We aimed to compare combined intraoperative chemotherapy and surgical resection with curative surgical resection alone in colorectal cancer patients. METHODS: We performed a multicenter, open-label, randomized, phase III trial. All eligible patients were randomized and assigned to intraoperative chemotherapy and curative surgical resection or curative surgical resection alone (1:1). Survival actualization after long-term follow-up was performed in patients analyzed on an intention-to-treat basis...
April 9, 2024: International Journal of Surgery