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Follicular thyroid carcinogenesis

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https://www.readbyqxmd.com/read/28610401/oncogenesis-of-thyroid-cancer
#1
Enas Younis
Thyroid neoplasms encompass a variety of lesions that range from benign adenomas to malignancies. These latter can be well-differentiated, poorly differentiated or undifferentiated (anaplastic) carcinomas. More than 95% of thyroid cancers are derived from thyroid follicular cells, while 2-3% (medullary thyroid cancers, MTC) originate from calcitonin producing C-cells. Over the last decade, investigators have developed a clearer understanding of genetic alterations underlying thyroid carcinogenesis. A number of point mutations and translocations are involved, not only in its tumorigenesis, but also as have potential use as diagnostic and prognostic indicators and therapeutic targets...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28551845/sostdc1-inhibits-follicular-thyroid-cancer-cell-proliferation-migration-and-emt-via-suppressing-pi3k-akt-and-mapk-erk-signaling-pathways
#2
Qinyi Zhou, Jun Chen, Jialin Feng, Yanan Xu, Wenjie Zheng, Jiadong Wang
The sclerostin domain containing protein 1 (SOSTDC1) is a cell signaling regulator involved in cell physiology and pathology. SOSTDC1 is known to have a suppressive effect on certain kinds of cancer. However, the role of SOSTDC1 in follicular thyroid cancer (FTC) remains unknown. We aimed to investigate if the expression of SOSTDC1 plays any roles in carcinogenesis and metastasis of FTC. We found a significantly down-regulated SOSTDC1 expression in follicular thyroid cancer samples. In addition, our data showed that ectopic expression of SOSTDC1 dramatically inhibited thyroid cancer cell proliferation in vitro and in nude mice...
May 27, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28123306/rassf1a-promoter-methylation-is-associated-with-increased-risk-of-thyroid-cancer-a-meta-analysis
#3
Feiyan Shou, Feng Xu, Gang Li, Zhenhua Zhao, Ying Mao, Fangfang Yang, Hongming Wang, Hangyuan Guo
OBJECTIVE: Previous studies have reported that Ras-associated domain family 1A (RASSF1A), the most commonly silenced tumor suppressor via promoter methylation, played vital roles in the development of carcinogenesis. The purpose of this meta-analysis was to determine whether RASSF1A promoter methylation increased the risk of thyroid cancer. METHODS: PubMed, Embase, ISI Web of Knowledge, and Chinese National Knowledge Infrastructure databases were searched to obtain eligible studies...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27910944/thyroid-sclerosing-mucoepidermoid-carcinoma-with-eosinophilia-a-clinicopathologic-and-molecular-analysis-of-a-distinct-entity
#4
Akeesha A Shah, Kristin La Fortune, Caitlyn Miller, Stacey E Mills, Zubair Baloch, Virginia LiVolsi, Sanja Dacic, Alyssa L Mahaffey, Marina Nikiforova, Yuri E Nikiforov, Raja R Seethala
Sclerosing mucoepidermoid carcinoma with eosinophilia is a rare thyroid neoplasm of uncertain pathogenesis that resembles salivary gland mucoepidermoid carcinoma. This multi-institutional study characterizes the clinicopathologic and molecular features of this tumor by utilizing next-generation sequencing to assess common mutations and gene fusions involved in thyroid carcinogenesis as well as fluorescence in-situ hybridization for MAML2 translocations typical of salivary gland mucoepidermoid carcinoma. Nine cases (6 females and 3 males, mean age: 59 years, range 30-77 years) were identified...
March 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27422900/trap1-regulates-cell-cycle-and-apoptosis-in-thyroid-carcinoma-cells
#5
Giuseppe Palladino, Tiziana Notarangelo, Giuseppe Pannone, Annamaria Piscazzi, Olga Lamacchia, Lorenza Sisinni, Girolamo Spagnoletti, Paolo Toti, Angela Santoro, Giovanni Storto, Pantaleo Bufo, Mauro Cignarelli, Franca Esposito, Matteo Landriscina
Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a heat shock protein 90 (HSP90) molecular chaperone upregulated in several human malignancies and involved in protection from apoptosis and drug resistance, cell cycle progression, cell metabolism and quality control of specific client proteins. TRAP1 role in thyroid carcinoma (TC), still unaddressed at present, was investigated by analyzing its expression in a cohort of 86 human TCs and evaluating its involvement in cancer cell survival and proliferation in vitro Indeed, TRAP1 levels progressively increased from normal peritumoral thyroid gland, to papillary TCs (PTCs), follicular variants of PTCs (FV-PTCs) and poorly differentiated TCs (PDTCs)...
September 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27420631/iodine-deficiency-and-thyroid-cancer-trends-in-three-regions-of-thailand-1990-2009
#6
Susanna D Mitro, Laura S Rozek, Patravoot Vatanasapt, Krittika Suwanrungruang, Imjai Chitapanarux, Songpol Srisukho, Hutcha Sriplung, Rafael Meza
BACKGROUND: Iodine deficiency may play a role in thyroid cancer carcinogenesis. Because Thailand has region-specific historical iodine deficiency, it is ideal to evaluate the potential impact of recent national iodine supplementation policies on thyroid cancer incidence trends. METHODS: We examined thyroid cancer trends in Thailand from 1990 to 2009 in three geographically separated populations (Songkhla Province [south], Chiang Mai Province [north], and Khon Kaen Province [northeast]), each with a different historical prevalence of iodine deficiency...
2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27267120/saha-induced-loss-of-tumor-suppressor-pten-gene-promotes-thyroid-carcinogenesis-in-a-mouse-model
#7
Xuguang Zhu, Dong Wook Kim, Li Zhao, Mark C Willingham, Sheue-Yann Cheng
Thyroid cancer is on the rise. Novel approaches are needed to improve the outcome of patients with recurrent and advanced metastatic thyroid cancers. FDA approval of suberoylanilide hydroxamic acid (SAHA; vorinostat), an inhibitor of histone deacetylase, for the treatment of hematological malignancies led to the clinical trials of vorinostat for advanced thyroid cancer. However, patients were resistant to vorinostat treatment. To understand the molecular basis of resistance, we tested the efficacy of SAHA in two mouse models of metastatic follicular thyroid cancer: Thrb(PV/PV) and Thrb(PV/PV)Pten(+/-) mice...
July 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27151833/upregulation-of-long-noncoding-rna-loc100507661-promotes-tumor-aggressiveness-in-thyroid-cancer
#8
Daham Kim, Woo Kyung Lee, Seonhyang Jeong, Mi-Youn Seol, Hyunji Kim, Kyung-Sup Kim, Eun Jig Lee, Jandee Lee, Young Suk Jo
Recent advances in next-generation sequencing have revealed a variety of long noncoding RNAs (lncRNAs). However, studies of lncRNAs are at a very early stage, our knowledge of the biological functions and clinical implications remains limited. To investigate the roles of lncRNAs in thyroid cancers, we verified 56 lncRNAs identified as potential cancer-promoting genes in a previous study that analyzed 2394 tumor SNP arrays from 12 types of cancer. Based on verified sequence information in NCBI and Ensembl, we ultimately selected three candidate lncRNAs for detailed analysis...
May 3, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/26998055/herpes-and-polyoma-family-viruses-in-thyroid-cancer
#9
Dimitris P Stamatiou, Stavros P Derdas, Odysseas L Zoras, Demetrios A Spandidos
Thyroid cancer is considered the most common malignancy that affects the endocrine system. Generally, thyroid cancer derives from follicular epithelial cells, and thyroid cancer is divided into well-differentiated papillary (80% of cases) and follicular (15% of cases) carcinoma. Follicular thyroid cancer is further divided into the conventional and oncocytic (Hürthle cell) type, poorly differentiated carcinoma and anaplastic carcinoma. Both poorly differentiated and anaplastic carcinoma can arise either de novo, or secondarily from papillary and follicular thyroid cancer...
March 2016: Oncology Letters
https://www.readbyqxmd.com/read/26902827/tert-promoter-mutations-in-thyroid-cancer
#10
REVIEW
Ali S Alzahrani, Rawan Alsaadi, Avaniyapuram Kannan Murugan, Bakr Bin Sadiq
Two mutations (C228T and C250T) in the promoter region of the telomerase reverse transcriptase (TERT) have recently been described in different types of cancer including follicular cell-derived thyroid cancer (TC). In this paper, we reviewed the rates of these mutations in different types and subtypes of TC, their association with a number of clinical and histopathological features and outcome of TC, and their potential diagnostic and prognostic roles in TC. The overall rate of these mutations in TC is about 14 % with least prevalence in the well-differentiated subtypes of papillary thyroid cancer (10-13 %)...
June 2016: Hormones & Cancer
https://www.readbyqxmd.com/read/26892809/cellular-apoptosis-susceptibility-cas-is-overexpressed-in-thyroid-carcinoma-and-maintains-tumor-cell-growth-a-potential-link-to-the-brafv600e-mutation
#11
Kerstin Holzer, Elisabeth Drucker, Scott Oliver, Juliane Winkler, Eva Eiteneuer, Esther Herpel, Kai Breuhahn, Stephan Singer
Thyroid carcinoma is among the most common malignant endocrine neoplasms with a rising incidence. Genetic alterations occurring in thyroid cancer frequently affect the RAS/RAF/MEK/ERK-pathway such as the oncogenic, kinase-activating BRAF(V600E) mutation. Nuclear transport receptors including importins and exportins represent an important part of the nuclear transport machinery providing nucleo-cytoplasmic exchange of macromolecules. The role of nuclear transport receptors in the development and progression of thyroid carcinomas is largely unknown...
April 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/26782318/unveiling-a-novel-biomarker-panel-for-diagnosis-and-classification-of-well-differentiated-thyroid-carcinomas
#12
N Monique Paricharttanakul, Kittirat Saharat, Daranee Chokchaichamnankit, Phaibul Punyarit, Chantragan Srisomsap, Jisnuson Svasti
Thyroid cancer is the most common human endocrine malignancy with increasing global incidence. Papillary thyroid carcinomas (PTC) and follicular thyroid carcinomas (FTC) are well-differentiated thyroid cancers (WDTC) accounting for 95% of all thyroid cancer cases, with survival rates of almost 100% when diagnosed early. Since PTC and FTC have different modes of metastasis, they require different treatment strategies. Standard diagnosis by fine needle aspiration with cytopathological examination can be inaccurate in approximately 10-30% of all cases and difficult to definitively classify as WDTC...
April 2016: Oncology Reports
https://www.readbyqxmd.com/read/26558233/thyroid-growth-and-cancer
#13
REVIEW
Dillwyn Williams
It is proposed that most papillary thyroid cancers originate in infancy and childhood, based on the early rise in sporadic thyroid carcinoma incidence, the pattern of radiation-induced risk (highest in those exposed as infants), and the high prevalence of sporadic papillary thyroid cancers in children and adolescents (ultrasound screening after the Fukushima accident). The early origin can be linked to the growth pattern of follicular cells, with a high mitotic rate in infancy falling to very low replacement levels in adult life...
September 2015: European Thyroid Journal
https://www.readbyqxmd.com/read/26488476/the-profile-of-heparanase-expression-distinguishes-differentiated-thyroid-carcinoma-from-benign-neoplasms
#14
Leandro Luongo Matos, Eloah Rabello Suarez, Thérèse Rachell Theodoro, Damila Cristina Trufelli, Carina Mucciolo Melo, Larissa Ferraz Garcia, Olivia Capela Grimaldi Oliveira, Maria Graciela Luongo Matos, Jossi Ledo Kanda, Helena Bonciani Nader, João Roberto Maciel Martins, Maria Aparecida Silva Pinhal
INTRODUCTION: The search for a specific marker that could help to distinguish between differentiated thyroid carcinoma and benign lesions remains elusive in clinical practice. Heparanase (HPSE) is an endo-beta-glucoronidase implicated in the process of tumor invasion, and the heparanase-2 (HPSE2) modulates HPSE activity. The aim of this study was to evaluate the role of heparanases in the development and differential diagnosis of follicular pattern thyroid lesions. METHODS: HPSE and HPSE2 expression by qRT-PCR, immunohistochemistry evaluation, western blot analysis and HPSE enzymatic activity were evaluated...
2015: PloS One
https://www.readbyqxmd.com/read/26324033/is-beclin-1-immunoreactivity-more-effective-than-hbme-1-in-diagnosis-of-papillary-thyroid-cancer
#15
C Yeşil, O Kandemir, H Haksever, T Dabakoğlu
BACKGROUND: Even though morphologic findings are generally important in the diagnosis of thyroid tumors, in some cases, morphologic similarities between benign and malignant lesions lead to noticeable differences in evaluation and different diagnoses in the same cases. In our study, we researched whether the autophagy-related protein Beclin-1 (BECN1) is a diagnostic marker in thyroid tumors, as well as its correlation with HBME-1, which has high sensitivity and specificity in distinguishing malignant thyroid lesions...
July 2015: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/26282269/multistage-carcinogenesis-and-the-incidence-of-thyroid-cancer-in-the-us-by-sex-race-stage-and-histology
#16
Rafael Meza, Joanne T Chang
BACKGROUND: Thyroid cancer has the fastest growing incidence in the US. However, the underlying causes are still under debate. METHODS: We analyzed thyroid cancer incidence in the SEER-9 registry from 1973-2010 using multistage carcinogenesis and age-period-cohort models. Multistage models were used to investigate differences in initiation, promotion and malignant conversion rates of thyroid tumors by sex, race, stage, and histology. Models were adjusted for period and cohort trends to investigate the contributions of each factor, and determine whether birth- or diagnosis-year better correlate with observed incidence patterns...
2015: BMC Public Health
https://www.readbyqxmd.com/read/26194071/mitochondrial-energy-metabolism-and-thyroid-cancers
#17
REVIEW
Junguee Lee, Joon Young Chang, Yea Eun Kang, Shinae Yi, Min Hee Lee, Kyong Hye Joung, Kun Soon Kim, Minho Shong
Primary thyroid cancers including papillary, follicular, poorly differentiated, and anaplastic carcinomas show substantial differences in biological and clinical behaviors. Even in the same pathological type, there is wide variability in the clinical course of disease progression. The molecular carcinogenesis of thyroid cancer has advanced tremendously in the last decade. However, specific inhibition of oncogenic pathways did not provide a significant survival benefit in advanced progressive thyroid cancer that is resistant to radioactive iodine therapy...
June 2015: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25960045/a-novel-stem-cell-associated-marker-identified-by-monoclonal-antibody-hesc5-3-differentiates-between-neoplastic-lesions-in-follicular-thyroid-neoplasms
#18
Annukka Heikkilä, Christian Fermér, Jaana Hagström, Johanna Louhimo, Hanna Mäenpää, Päivi Siironen, Ilkka Heiskanen, Olle Nilsson, Johanna Arola, Caj Haglund
Follicular thyroid lesions are the bane of cytopathology. Differentiation between adenoma and carcinoma is impossible, and often these neoplasms are indistinguishable even from uninodular goitre. In other cancers as well, a theory of stem cells as the origin of cancer has been discussed in thyroid carcinogenesis. We aimed to examine a novel stem cell associated marker identified by monoclonal antibody HESC5:3 in follicular lesions in an attempt to find a marker for differential diagnosis in thyroid cytopathology...
July 2015: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/25804379/when-thyroid-carcinoma-goes-bad-a-morphological-and-molecular-analysis
#19
REVIEW
Sylvia Papp, Sylvia L Asa
Thyroid carcinomas of follicular epithelial derivation are common and generally well-behaved malignancies with excellent cure and survival rates. However, a subset of these carcinomas, whether well-differentiated, poorly differentiated, or anaplastic, is highly aggressive, manifesting with local invasion, recurrence, and distant metastasis. The recognition of dedifferentiation is of paramount importance. In addition, the challenge for Pathologists is to identify the rare aggressive differentiated carcinomas so that treatment may be tailored appropriately...
March 2015: Head and Neck Pathology
https://www.readbyqxmd.com/read/25720323/microrna-deep-sequencing-reveals-master-regulators-of-follicular-and-papillary-thyroid-tumors
#20
Veronika Mancikova, Esmeralda Castelblanco, Elena Pineiro-Yanez, Javier Perales-Paton, Aguirre A de Cubas, Lucia Inglada-Perez, Xavier Matias-Guiu, Ismael Capel, Maria Bella, Enrique Lerma, Garcilaso Riesco-Eizaguirre, Pilar Santisteban, Francisco Maravall, Didac Mauricio, Fatima Al-Shahrour, Mercedes Robledo
MicroRNA deregulation could be a crucial event in thyroid carcinogenesis. However, current knowledge is based on studies that have used inherently biased methods. Thus, we aimed to define in an unbiased way a list of deregulated microRNAs in well-differentiated thyroid cancer in order to identify diagnostic and prognostic markers. We performed a microRNA deep-sequencing study using the largest well-differentiated thyroid tumor collection reported to date, comprising 127 molecularly characterized tumors with follicular or papillary patterns of growth and available clinical follow-up data, and 17 normal tissue samples...
June 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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