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Follicular Thyroid Carcinoma

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https://www.readbyqxmd.com/read/27914217/hla-g-3-untranslated-region-polymorphic-sites-associated-with-increased-hla-g-production-are-more-frequent-in-patients-exhibiting-differentiated-thyroid-tumors
#1
Nathalie Lobo de Figueiredo-Feitosa, Gustavo Martelli Palomino, Daiani Cristina Cilião Alves, Celso Teixeira Mendes Junior, Eduardo Antonio Donadi, Léa Maria Zanini Maciel
BACKGROUND: HLA-G is a non-classical class I histocompatibility molecule implicated on the immune escape mechanism of tumor cells. We evaluated the genetic diversity of HLA-G 3' untranslated region (3'UTR) and associated polymorphic sites with clinical presentation and with the magnitude of HLA-G thyroid expression. PATIENTS AND METHODS: Polymorphic sites at 3'UTR (14bpINS/DEL, +3003C/T, +3010C/G, +3027A/C, +3035C/T, +3142C/G, +3187A/G, +3196C/G) were characterized by sequencing analyses in blood samples of 72 patients exhibiting papillary thyroid carcinoma (PTC), 22 follicular thyroid carcinomas (FTC), 19 follicular adenomas (FA), 21 colloid goiters and 156 healthy controls...
December 2, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27912795/follicular-thyroid-carcinoma-presenting-as-solitary-liver-metastasis-a-case-report
#2
Azhar J Battoo, Zubaida Rasool, Zahoor A Sheikh, Altaf G Haji
BACKGROUND: Distant metastasis from differentiated thyroid carcinoma at presentation is rare and isolated liver metastasis on presentation is almost unknown. We report a case of primary follicular carcinoma of the thyroid with isolated liver metastasis at presentation. CASE PRESENTATION: A 65-year-old man of Kashmiri origin presented to our tertiary referral center with obstructive jaundice; he was evaluated with magnetic resonance cholangiopancreatography and positron emission tomography-computed tomography...
December 3, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27910944/thyroid-sclerosing-mucoepidermoid-carcinoma-with-eosinophilia-a-clinicopathologic-and-molecular-analysis-of-a-distinct-entity
#3
Akeesha A Shah, Kristin La Fortune, Caitlyn Miller, Stacey E Mills, Zubair Baloch, Virginia LiVolsi, Sanja Dacic, Alyssa L Mahaffey, Marina Nikiforova, Yuri E Nikiforov, Raja R Seethala
Sclerosing mucoepidermoid carcinoma with eosinophilia is a rare thyroid neoplasm of uncertain pathogenesis that resembles salivary gland mucoepidermoid carcinoma. This multi-institutional study characterizes the clinicopathologic and molecular features of this tumor by utilizing next-generation sequencing to assess common mutations and gene fusions involved in thyroid carcinogenesis as well as fluorescence in-situ hybridization for MAML2 translocations typical of salivary gland mucoepidermoid carcinoma. Nine cases (6 females and 3 males, mean age: 59 years, range 30-77 years) were identified...
December 2, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27904709/braf-and-epithelial-mesenchymal-transition-in-papillary-thyroid-carcinoma-challenging-the-roles-of-snail-and-e-cadherin
#4
Brendon Mitchell, Dominick Leone, Shi Yang, Ashraf Khan, Meera Mahalingam, Jagdish Dhingra
OBJECTIVE: In papillary thyroid carcinoma (PTC), while the role of BRAF is well established, the contribution of BRAF to epithelial-mesenchymal transition is not. STUDY DESIGN/SETTING: To elucidate the relationship between BRAF, surrogates of epithelial-mesenchymal transition (Snail, E-cadherin) and established histopathologic prognosticators in papillary thyroid carcinoma. SUBJECTS/METHODS: In this IRB approved cross-sectional study, 50 cases of archived annotated PTC samples were retrieved and immunohistochemically stained for Snail and E-cadherin protein...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27904595/cd56-hbme-1-and-cytokeratin-19-expressions-in-papillary-thyroid-carcinoma-and-nodular-thyroid-lesions
#5
Senay Erdogan-Durmus, Deniz Ozcan, Enver Yarikkaya, Ali Kurt, Aynur Arslan
BACKGROUND: Carcinomas of the thyroid follicular epithelium are the most common cancers of the endocrine system. In the diagnosis of thyroid nodules and tumors, the gold standard is histological evaluation. In cases which have morphological overlap, immunohistochemistry is needed for differential diagnosis. The purpose of this study is to investigate the expressions of CD56, HBME-1, cytokeratin 19 (CK19) antibodies in papillary thyroid carcinoma (PTC) and thyroid nodular lesions and their contributions to differential diagnosis...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27899986/metastasis-of-renal-cell-carcinoma-to-the-parathyroid-gland-16-years-after-radical-nephrectomy-a-case-report
#6
Liborio Torregrossa, Maria Isabella Rotondo, Andrea Cacciato Insilla, David Galleri, Federica Guidoccio, Paolo Miccoli, Virginia A Livolsi, Fulvio Basolo
Renal cell carcinoma (RCC) has a high metastatic potential, and most commonly metastasizes via the bloodstream, although lymphatic metastases also occur. RCC is well-known for its propensity to metastasize to unusual sites, and late metastasis, even after a number of years, is common. The occurrence of RCC metastasis to the head and neck region is uncommon, and occurs primarily in the thyroid gland and in patients with widespread dissemination. Involvement of the parathyroid gland in metastatic carcinoma is extremely rare...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27896649/the-micropapillary-hobnail-variant-of-papillary-thyroid-carcinoma-a-review-of-series-described-in-the-literature-compared-to-a-series-from-one-southern-italy-pathology-institution
#7
REVIEW
Antonio Ieni, Valeria Barresi, Roberta Cardia, Luana Licata, Flavia Di Bari, Salvatore Benvenga, Giovanni Tuccari
Papillary thyroid carcinoma (PTC) has a good prognosis with a 10-yr survival greater than 90%. Recently, a micro-papillary pattern with hobnail appearance (MPHC) in PTC has been indicated as associated with poor prognosis, but this suggestion is based only on a few cases from geographical areas different from ours. Two-hundred ninety-nine consecutive PTC cases were collected between the years of 1992 and 2014 at our institution. The corresponding histologic sections (at least 6 for each case) were stained with hematoxylin and eosin and reviewed independently by two pathologists to reach a consensus on the identification and quantification of the MPHC...
November 28, 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27895796/promotion-of-metastasis-of-thyroid-cancer-cells-via-nrp-2-mediated-induction
#8
Dom-Gene Tu, Wen-Wei Chang, Ming-Shiou Jan, Chi-Wen Tu, Yin-Che Lu, Chien-Kuo Tai
Tumor-node-metastasis is one of the leading causes of morbidity and mortality in thyroid cancer patients. Upregulation of vascular endothelial growth factor-C (VEGF-C) increases the migratory ability of thyroid cancer cells to lymph nodes. Expression of neuropilin-2 (NRP-2), the co-receptor of VEGF-C, has been reported to be correlated with lymph node metastasis in human thyroid cancer. The present study investigated the role of VEGF-C/NRP-2 signaling in the regulation of metastasis of two different types of human thyroid cancer cells...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27893191/young-investigator-challenge-molecular-testing-in-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features
#9
Xiaoyin Sara Jiang, Grant P Harrison, Michael B Datto
BACKGROUND: Molecular testing provides an important ancillary study for thyroid nodules with indeterminate cytology. The nomenclature shift to "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) will impact the performance of molecular tests. For the current study, the authors reviewed the performance of the Afirma gene-expression classifier (GEC) and the University of Pittsburgh Medical Center (UPMC) targeted mutation panel tests in thyroid nodules that were subsequently diagnosed as NIFTP on surgical resection...
November 28, 2016: Cancer
https://www.readbyqxmd.com/read/27891483/cystadenoma-in-retromolar-region-a-case-report
#10
Sheetal, V Ramesh, P D Balamurali, B Premalatha, Monika Chaudhary
Cystadenoma is a rare benign salivary gland epithelial tumor that is characterized by intraluminal papillary projection. Majority of the tumors are located in minor salivary glands and usually occur in palatal and buccal mucosa, but rarely found in retromolar area. Clinically it is difficult to differentiate it from other minor salivary gland tumors, and diagnosis is chiefly based on characteristic clinical features and immunohistochemistry. We present a case of Cystadenoma arising from the minor salivary gland in retromolar area of a 44 year old female patient with a special emphasis on the immunohistochemistry to rule out the metastatic follicular carcinoma of thyroid...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27873522/extremely-well-differentiated-papillary-thyroid-carcinoma-resembling-adenomatous-hyperplasia-can-metastasize-to-the-skull-a-case-report
#11
Ju Yeon Pyo, Jisup Kim, Sung Eun Choi, Eunah Shin, Seok Woo Yang, Cheong Soo Park, Seok Mo Kim, Soonwon Hong
We describe herein histologic, immunohistochemical, and molecular findings and clinical manifestations of a rare case of an extremely well differentiated papillary thyroid carcinoma (EWD-PTC). Similarly, it is also difficult to diagnose follicular variant papillary thyroid carcinoma (FVPTC), whose diagnosis is still met with controversy. A recently reported entity of well-differentiated tumor of uncertain malignant potential (WDT-UMP) is added to the diagnostic spectrum harboring EWD-PTC and FVPTC. We report this case, because EWD-PTC is different from FVPTC in its papillary architecture, and also from WDT-UMP in its recurrence and metastatic pattern...
January 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27870787/can-nodular-hyperplasia-of-the-thyroid-gland-be-differentiated-from-follicular-adenoma-and-follicular-carcinoma-by-ultrasonography
#12
Sun Hye Jeong, Hyun Sook Hong, Eun Hye Lee
OBJECTIVES: The aim of this study was to evaluate the ultrasonographic features for differentiation of follicular thyroid lesions. METHODS: Ultrasonographic features of surgically confirmed 56 follicular adenoma (FA), 22 follicular carcinoma (FC), and 100 nodular hyperplasia (NH) were evaluated using univariable and multivariable multinomial logistic regression analyses, receiver operating characteristic analyses, and areas under the curve. RESULTS: Tumor diameter, margin, echotexture, cystic changes, calcification, hypoechoic rim, and vascularity were significant on univariable analysis...
December 2016: Ultrasound Quarterly
https://www.readbyqxmd.com/read/27869424/-study-of-medullary-thyroid-carcinoma-from-a-proband
#13
Laura Morlán Herrador, Antonio de Arriba, Gloria Miguel, Marta Ferrera, José I Labarta
Thyroid cancer is an uncommon type of cancer, accounting less than 1% of all cancers in adults, and 0.5-3% of all cancers in children. There are four different types: papillary carcinoma (80-90% of cases), follicular (5-10%), medullary (5%) and anaplastic cell (2-3%). Eighty per cent of cases of medullary thyroid cancer are sporadic, but 20% are associated with an inherited syndrome that is divided into three groups: multiple endocrine neoplasia type 1, multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma...
December 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27862483/cytological-features-of-solid-variants-of-papillary-thyroid-carcinoma-a-fine-needle-aspiration-cytology-study-of-18-cases
#14
M Higuchi, M Hirokawa, A Suzuki, N Takada, N Yamao, S Kuma, A Miyauchi
OBJECTIVE: Solid variants of papillary thyroid carcinoma (SV-PTC) are rare, and there have been few reports describing the cytological findings of such variants. METHODS: The cytological features of cellular specimens aspirated from 18 histologically confirmed SV-PTC cases were evaluated, retrospectively. RESULTS: Solid and small papillary clusters were observed in 14 (77.8%) and 13 (72.2%) cases, respectively. The incidences of large papillary clusters (11...
November 13, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/27858102/interleukin-10-expression-is-related-to-aggressiveness-and-poor-prognosis-of-patients-with-thyroid-cancer
#15
Lucas Leite Cunha, Elaine Cristina Morari, Sueli Nonogaki, Marjory Alana Marcello, Fernando Augusto Soares, José Vassallo, Laura Sterian Ward
Most patients with thyroid cancer will evolve very well with current therapies. However, 10-30% of these patients will present recurrent disease and some of them will eventually die. IL-10 is an anti-inflammatory and immunosuppressive cytokine that can contribute to the immune escape of neoplastic cells. We aimed to investigate IL-10 as a molecular marker to improve the clinical management of patients with thyroid cancer. We retrospectively studied 162 patients with follicular cell-derived thyroid cancer who attended to our institution, including 63 classic papillary thyroid carcinomas, 46 follicular variant of papillary thyroid carcinomas, 11 poorly differentiated thyroid carcinomas and 42 follicular thyroid carcinomas...
November 17, 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27856495/clinical-outcomes-of-a-cohort-of-patients-with-central-nervous-system-metastases-from-thyroid-cancer
#16
Joana Simões-Pereira, Daniel Macedo, Maria João Bugalho
INTRODUCTION: Metastases to central nervous system (M1-CNS) are rarely reported in thyroid cancer (TC) patients. We aimed to characterize patients with M1-CNS from TC followed in our department. METHODS: Review of the medical records of 27 patients with TC-related M1-CNS. RESULTS: Mean age at TC diagnosis was 56.9 ± 19.1 years. Papillary TC (55.6%) was the commonest histological type, followed by poorly differentiated (18.5%), medullary (11...
November 2016: Endocrine Connections
https://www.readbyqxmd.com/read/27852075/thyroid-atypia-follicular-lesion-of-undetermined-significance-attitudes-towards-the-diagnosis-of-bethesda-system-iii-nodules
#17
Lourdes Estrada Muñoz, Cristina Díaz Del Arco, Luis Ortega Medina, M Jesús Fernández Aceñero
OBJECTIVES: To review our institutional experience and to analyze the clinical decisions made after a cytological diagnosis of atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS). STUDY DESIGN: This is a retrospective review of all thyroid fine-needle aspiration (FNA) cytologies performed in the Hospital Clínico San Carlos (Madrid) between 2010 and 2014. RESULTS: One hundred thirty thyroid FNA were categorized as AUS/FLUS (5%)...
November 17, 2016: Acta Cytologica
https://www.readbyqxmd.com/read/27845971/the-follicular-variant-of-papillary-thyroid-cancer-and-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp
#18
Joseph Scharpf, Dipti Kamani, Peter M Sadow, Gregory W Randolph
PURPOSE OF REVIEW: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a new terminology proposed for encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC). Recently, thyroid cancer incidence has increased dramatically, without affecting related mortality rate. This increase is widely attributed to the intensified surveillance leading to a substantial increase in the diagnosis of small classic papillary thyroid cancers and EFVPTCs...
January 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/27843812/an-unusual-case-of-malignant-struma-ovarii-causing-thyrotoxicosis
#19
Elli Anagnostou, Antonios Polymeris, Georgios Morphopoulos, Alexios Travlos, Vassiliki Sarantopoulou, Irini Papaspyrou
BACKGROUND: Struma ovarii (SO) is a specialized monodermal teratoma predominantly composed of mature thyroid tissue, accounting for approximately 5% of all ovarian teratomas. Thyrotoxicosis is seen in about 8% of patients with SO. Most SO cases are benign with only 5-10% being malignant, and malignant SO causing thyrotoxicosis is very uncommon. CASE: A 64-year-old woman had been diagnosed with thyrotoxicosis 2 years previously. The thyroid gland was palpable with a micronodular texture, and the patient was euthyroid under carbimazole...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27834461/clinicopathological-significance-of-loss-of-p27kip1-expression-in-papillary-thyroid-carcinoma
#20
Nae Yu Kim, Jin Hwa Kim, Jung-Soo Pyo, Won Jin Cho
INTRODUCTION: A meta-analysis was done to investigate the clinicopathological significance of the loss of p27kip1 expression in papillary thyroid carcinoma (PTC). METHODS: The meta-analysis involving 17 studies included 1,652 PTC and 328 benign cases. The rate of p27kip1 expression loss in PTC and benign lesions, and the correlations between p27kip1 expression loss and clinicopathological characteristics of PTC were determined. RESULTS: The estimated rate of p27kip1 expression loss was 0...
November 5, 2016: International Journal of Biological Markers
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