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Follicular Thyroid Carcinoma

Mohsen Qutbi, Babak Shafeie, Mahasti Amoui, Faraj Tabeie, Zahra Azizmohammadi, Ali Mahmoud-Pashazadeh, Hamid Javadi, Majid Assadi, Isa Neshandar Asli
BACKGROUND: Because one of the major sites for metastasis of thyroid cancers is the lung, studying the pattern of pulmonary metastasis may provide useful information for the effective treatment of these patients. In this study, by assessing the metastasis pattern, we aimed to identify the factors that may affect prognosis and response to treatment in patients with differentiated thyroid carcinoma (DTC) with pulmonary metastasis. METHODS: This retrospective study included 75 patients with DTC with pulmonary metastasis who were referred to our nuclear medicine section over a period of 10 years...
October 18, 2016: Clinical Nuclear Medicine
Soo Yeon Hahn, Jung Hee Shin, Hyun Kyung Lim, So Lyung Jung, Young Lyun Oh, In Ho Choi, Chan Kwon Jung
BACKGROUND: A recent concept was proposed that the non-invasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) reclassified as "non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is benign. Our aim was to identify the differences between NIFTP and non-NIFTP preoperatively. METHODS: This retrospective study included a total of 208 patients with 208 FVPTCs that were surgically confirmed at 3 university hospitals from 2008 through 2014...
October 19, 2016: Clinical Endocrinology
Paula Boaventura, Rui Batista, Ana Pestana, Marta Reis, Adélia Mendes, Catarina Eloy, Manuel Sobrinho-Simoes, Paula Soares
Objective - The aim of this study is to evaluate the frequency and molecular characteristics of TERTp mutations in thyroid adenomas and carcinomas occurring in the low dose radiation exposure tinea capitis setting. Design and methods - Twenty seven patients with 34 well differentiated thyroid carcinomas and 28 patients with 29 follicular adenomas diagnosed in a Portuguese tinea capitis cohort of 1375 patients, were studied. Blood samples were obtained from all the patients. Screening for TERTp mutations was performed by PCR amplification followed by Sanger sequencing...
October 19, 2016: European Journal of Endocrinology
X Chen, F X Dou, X B Cheng, A T Guo, H Y Shi
Objective: To study the clinicopathologic features of thyroid-like follicular renal cell carcinoma. Methods: Clinical data were collected in 5 cases of thyroid-like follicular renal cell carcinoma. HE staining and immunohistochemistry were carried out in surgically-removed specimen to analyze the clinical and pathological features with review of the literatures. Results: The patients aged 20-55 years, with one male and four females; the tumor occurred in the left kidney in three cases and right kidney in two cases...
October 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Maral Mokhtari, Perikala Vijayananda Kumar, Kamran Hayati
BACKGROUND: Cystic papillary thyroid carcinoma (CPTC) is a variant of papillary carcinoma that has many mimickers in cytological grounds. AIM: To study the cytomorphologic features of CPTC and compare them to those of other cystic thyroid lesions using fine-needle aspiration cytology (FNAC). We also aimed to identify the cytomorphologic features that distinguish CPTC from other cystic thyroid lesions. MATERIALS AND METHODS: Seventy-three cases of CPTC were included in the study...
July 2016: Journal of Cytology
Shih-Ping Cheng, Po-Sheng Yang, Ming-Nan Chien, Ming-Jen Chen, Jie-Jen Lee, Chien-Liang Liu
BACKGROUND AND OBJECTIVES: The induction of tumor-associated carbohydrate antigen results from altered glycosylation in transformed cells. Globo H is a hexasaccharide glycosphingolipid overexpressed on malignancies of epithelial origin and has become an attractive vaccine target. We aimed to investigate the expression patterns and prognostic value of Globo H in thyroid neoplasms. METHODS: Globo H expression was examined by immunohistochemical analysis using commercial and in-house tissue microarrays...
October 18, 2016: Journal of Surgical Oncology
Geetesh Manik, John Jose, B Hygriv Rao
Intra-cardiac extension of tumour thrombus of follicular carcinoma of thyroid is uncommon. We report a case of advanced thyroid carcinoma where tumour thrombus was well profiled with CT scan and transesophageal echo images and extension was noted from SVC into right atrium, with clinical features of superior vena cava syndrome. The clinical significance of the "ring sign" is discussed.
September 2016: Indian Heart Journal
Marc Gregory Yu, Jenny Maureen Atun
Tuberculous (TB) lymphadenitis can mimic cervical node metastasis from papillary thyroid carcinoma (PTC) since the distribution and appearance of affected lymph nodes are similar. We present the case of an asymptomatic 50-year-old Filipino who sought consult for a gradually enlarging anterior neck mass and a single palpable cervical lymph node. Preoperative workup suggested a thyroid malignancy with nodal metastasis. He underwent total thyroidectomy with node dissection where histopathology confirmed follicular variant- (FV-) PTC...
2016: Case Reports in Medicine
Beatriz G Cavalheiro, Leandro L Matos, Ana Kober N Leite, Marco Aurélio V Kulcsar, Claudio R Cernea, Lenine G Brandão
Objective: The aim of the present study was to describe the epidemiologic data, histological type, treatment and follow-up of the 811 patients treated for thyroid cancer in Instituto do Câncer do Estado de São Paulo (ICESP) over 5 years. Materials and methods: Retrospective analyses of electronic chart information. Results: There were 679 cases (83.7%) of papillary thyroid cancer, 61 (7.5%) of follicular carcinoma, 54 (6.7%) of medullary carcinoma, 11 (1...
October 10, 2016: Archives of Endocrinology and Metabolism
Giovanni Tallini, R Michael Tuttle, Ronald A Ghossein
CONTEXT: The purpose of this review is to provide the historical context to recent developments in the classification of the follicular variant of papillary thyroid carcinoma (FVPTC), an entity that has long created significant controversy. The scope is to illustrate the evolution of the diagnostic criteria for papillary thyroid carcinoma, clarifying the role of molecular analysis, and the impact on patient management. EVIDENCE ACQUISITION: A PubMed search using the terms "follicular variant" and "papillary thyroid carcinoma" covering the years 1960-2016 was performed...
October 12, 2016: Journal of Clinical Endocrinology and Metabolism
Julietta V Rau, Valerio Graziani, Marco Fosca, Chiara Taffon, Massimiliano Rocchia, Pierfilippo Crucitti, Paolo Pozzilli, Andrea Onetti Muda, Marco Caricato, Anna Crescenzi
Recent investigations strongly suggest that Raman spectroscopy (RS) can be used as a clinical tool in cancer diagnosis to improve diagnostic accuracy. In this study, we evaluated the efficiency of Raman imaging microscopy to discriminate between healthy and neoplastic thyroid tissue, by analyzing main variants of Papillary Thyroid Carcinoma (PTC), the most common type of thyroid cancer. We performed Raman imaging of large tissue areas (from 100 × 100 μm(2) up to 1 × 1 mm(2)), collecting 38 maps containing about 9000 Raman spectra...
October 11, 2016: Scientific Reports
Tommaso Bizzarro, Maurizio Martini, Sara Capodimonti, Patrizia Straccia, Celestino Pio Lombardi, Alfredo Pontecorvi, Luigi Maria Larocca, Esther Diana Rossi
BACKGROUND: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) represents a challenge for the diagnosis and management of thyroid carcinoma. Some authors have proposed histological criteria that are able to distinguish NIFTPs from invasive follicular variant of papillary thyroid carcinoma (I-FVPTC). Hence, NIFTPs may have repercussions in the diagnostic categories on fine-needle aspiration. In the current study, the authors evaluated the criteria for NIFTPs on liquid-based cytology samples...
October 2016: Cancer
Tanja Makazlieva, Olivija Vaskova, Venjamin Majstorov
INTRODUCTION: Thyroid malignomas are a heterogeneous group of neoplasm consisting of most frequent differentiated encountered carcinomas, papillary and follicular thyroid carcinoma, then medullary thyroid carcinoma originating from neuroendocrine calcitonin-producing C-cells and rare forms of thyroid lymphomas arising from intrathyroidal lymphatic tissue, thyroid sarcomas and poorly differentiated anaplastic thyroid carcinoma. There are increasing numbers of epidemiological studies and publications that have suggested increased incidence rate of thyroid carcinomas...
September 15, 2016: Open Access Macedonian Journal of Medical Sciences
Rame Miftari, Valdete Topçiu, Adem Nura, Valdete Haxhibeqiri
PURPOSE: Papillary carcinoma is the most frequent type of thyroid cancer and was considered the most benign of all thyroid carcinomas, with a low risk of distant metastases. However, there are some variants of papillary thyroid carcinoma that have affinity to spread in many organs, such as: lymph nodes, lungs and bones. AIM: The aim of this study was presentation of a case with papillary carcinoma of the thyroid gland, very persistent and resistant in treatment with I 131...
July 27, 2016: Medical Archives
Misa Yoshida, Satoshi Hamanoue, Masafumi Seki, Mio Tanaka, Kenichi Yoshida, Hiroaki Goto, Seishi Ogawa, Junko Takita, Yukichi Tanaka
Anaplastic sarcoma of the kidney (ASK) is a tumor found in the pediatric age group and shows many histopathological similarities to pleuropulmonary blastoma (PPB). We present a 12-year-old girl diagnosed with ASK and, three years later, with thyroid follicular carcinoma (TFC) with DICER1 abnormalities. Germline insertion/deletion (p.G1809_S1814delinsA) and independent somatic mutations (p.E1705K in ASK, p.E1813D in TFC) were identified. All of these abnormalities are in the catalytic domain of RNase IIIb. Single-nucleotide polymorphism genotyping microarray revealed independent copy number alterations (trisomy 8, monosomy 10, loss of 17p and partial gain of 17q in ASK; trisomy 5 and partial loss of Xq in TFC)...
September 30, 2016: Human Pathology
Sujay Kakarmath, Howard T Heller, Caroline A Alexander, Edmund S Cibas, Jeffrey F Krane, Justine A Barletta, Neal I Lindeman, Mary C Frates, Carol B Benson, Atul A Gawande, Nancy L Cho, Matthew Nehs, Francis D Moore, Ellen Marqusee, Mathew I Kim, P Reed Larsen, Norra Kwong, Trevor E Angell, Erik K Alexander
CONTEXT: Mutations in the BRAF and RAS oncogenes are responsible for most well-differentiated thyroid cancer. Yet, our clinical understanding of how BRAF-positive and RAS-positive thyroid cancers differ is incomplete. OBJECTIVE: We correlated clinical, radiographic, and pathologic findings from patients with thyroid cancer harboring a BRAF or RAS mutation. DESIGN: Prospective cohort study Setting: Academic, tertiary care hospital Patients: 101 consecutive patients with well-differentiated thyroid cancer Main Outcome Measure: We compared the clinical, sonographic, and pathologic characteristics of patients with BRAF-positive cancer to those with RAS-positive cancer...
September 30, 2016: Journal of Clinical Endocrinology and Metabolism
C Anuradha, M T Manipadam, H S Asha, N Dukhabandhu, D Abraham, M J Paul
AIM: To describe two new ultrasound signs for thyroid nodules - "nodule in nodule" and "hypoechoic internal septae" and assess their usefulness in differentiating follicular variant of papillary thyroid carcinoma (FVPTC) from benign thyroid nodules (BTN). METHODOLOGY: Ultrasound findings of 210 patients with histopathologically proven FVPTC (68 nodules, M:F=13:47 with mean age of 39.5±11.9 years) and BTN (165 nodules, (M:F=41:109 with mean age of 44±11.3 years) were retrospectively reviewed from PACS by a single radiologist blinded to the final diagnosis...
May 2016: Ultrasound Int Open
Rohit Ranganath, Manish A Shaha, Bin Xu, Jocelyn Migliacci, Ronald Ghossein, Ashok R Shaha
BACKGROUND: de Quervain's thyroiditis is an inflammatory condition of the thyroid mostly treated medically, rarely requiring surgical treatment. We intend to review the surgical experience with de Quervain's thyroiditis at a tertiary cancer center over a period of 22years. METHODS: A retrospective review of medical records from 1992 to 2014 at a tertiary cancer center was performed and all patients with a histopathological diagnosis of de Quervain's thyroiditis were included...
August 18, 2016: American Journal of Otolaryngology
Ana Lopez-Campistrous, Esther Ekpe Adewuyi, Matthew G K Benesch, Yi Man Ko, Raymond Lai, Aducio Thiesen, Jay Dewald, Peng Wang, Karen Chu, Sunita Ghosh, David C Williams, Larissa J Vos, David N Brindley, Todd P W McMullen
Dedifferentiation of follicular cells is a central event in resistance to radioactive iodine and patient mortality in papillary thyroid carcinoma (PTC). We reveal that platelet derived growth factor receptor alpha (PDGFRα) specifically drives dedifferentiation in PTC by disrupting the transcriptional activity of thyroid transcription factor-1 (TTF1). PDGFRα activation dephosphorylates TTF1 consequently shifting the localization of this transcription factor from the nucleus to the cytoplasm. TTF1 is required for follicular cell development and disrupting its function abrogates thyroglobulin production and sodium iodide transport...
September 10, 2016: EBioMedicine
Andrej Vogrin, Hana Besic, Nikola Besic, Maja Marolt Music
BACKGROUND: Preoperative ultrasound (US) evaluation of central and lateral neck compartments is recommended for all patients undergoing a thyroidectomy for malignant or suspicious for malignancy cytologic or molecular findings. Our aim was to find out how frequent was recurrence in regional lymph nodes in patients with follicular or Hürthle cell neoplasm and usefulness of preoperative neck US investigation in patients with neoplasm. PATIENTS AND METHODS: Altogether 737 patients were surgically treated because of follicular or Hürthle cell neoplasms from 1995 to 2014 at our cancer comprehensive center, among them 207 patients (163 females, 44 males; mean age 52 years) had thyroid carcinoma...
September 1, 2016: Radiology and Oncology
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