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Follicular Thyroid Carcinoma

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https://www.readbyqxmd.com/read/29239042/special-types-of-thyroid-carcinoma
#1
REVIEW
Zubair W Baloch, Virginia A LiVolsi
This article reviews the small percentage of thyroid tumours that are not classified as classic papillary thyroid carcinoma, follicular thyroid carcinoma, and medullary thyroid carcinoma. It includes subtypes of papillary thyroid carcinoma, including, tall-cell, hobnail/micropapillary, columnar cell, diffuse sclerosing and solid variants. Poorly differentiated carcinoma, high-grade carcinoma and anaplastic thyroid carcinoma are reviewed. Also discussed are entities that are unusual but need to be recognized as primary thyroid neoplasms, i...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29239041/hereditary-and-familial-thyroid-tumours
#2
REVIEW
Julie Guilmette, Vania Nosé
The worldwide incidence of thyroid malignancies has been increasing rapidly. Sensitive imaging modalities and early detection of thyroid lesions have made thyroid cancers the most rapidly increasing cancers in the USA in 2017 (SEER Cancer Facts, 2017). Clinical awareness of potential risk factors, such as inherited thyroid cancers, has allowed earlier recognition of more vulnerable population clusters. Hereditary thyroid neoplasms arising from calcitonin-producing C cells are known as familial medullary thyroid carcinomas (FMTCs), and include well-documented syndromes such as multiple endocrine neoplasia IIA or IIB, and pure familial medullary thyroid carcinoma syndrome...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29239040/molecular-pathology-of-thyroid-tumours-of-follicular-cells-a-review-of-genetic-alterations-and-their-clinicopathological-relevance
#3
REVIEW
Giorgia Acquaviva, Michela Visani, Andrea Repaci, Kerry J Rhoden, Dario de Biase, Annalisa Pession, Tallini Giovanni
Thyroid cancer is the most common endocrine malignancy. Knowledge of the molecular pathology of thyroid tumours originating from follicular cells has greatly advanced in the past several years. Common molecular alterations, such as BRAF p.V600E, RAS point mutations, and fusion oncogenes (RET-PTC being the prototypical example), have been, respectively, associated with conventional papillary carcinoma, follicular-patterned tumours (follicular adenoma, follicular carcinoma, and the follicular variant of papillary carcinoma/non-invasive follicular thyroid neoplasm with papillary-like nuclear features), and with papillary carcinomas from young patients and arising after exposure to ionising radiation, respectively...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29239036/a-user-s-guide-to-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp
#4
REVIEW
Yin P Hung, Justine A Barletta
The term non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently introduced to replace a subset of follicular variant of papillary thyroid carcinoma (FVPTC). The goal of this change was to promote more conservative management of these tumours and spare patients the psychological burden of a cancer diagnosis. The histological diagnosis of NIFTP is stringent: the tumour needs to demonstrate encapsulation or circumscription, a purely follicular architecture and the presence of nuclear features of papillary thyroid carcinoma, while lacking capsular and vascular invasion, a significant component of solid growth and high-grade features (increased mitotic activity and necrosis)...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29238850/risk-factors-for-central-neck-lymph-node-metastases-in-micro-versus-macro-%C3%A2-clinically-node%C3%A2-negative-papillary-thyroid-carcinoma
#5
Luca Sessa, Celestino Pio Lombardi, Carmela De Crea, Serena Elisa Tempera, Rocco Bellantone, Marco Raffaelli
BACKGROUND: Tumor size has been advocated as possible risk factors for occult central lymph node metastases (CNM) in papillary thyroid carcinoma (PTC) patients. This prospective study evaluated factors that could identify patients at higher risk of occult CNM, especially comparing micro-PTC and macro-PTC. METHODS: One hundred and eighty-six patients were recruited. All the patients had cN0 clinically unifocal PTC and underwent total thyroidectomy and bilateral prophylactic central neck dissection...
December 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29234625/insight-into-differentiated-thyroid-cancer-gross-pathological-specimen-shrinkage-and-its-influence-on-tnm-staging
#6
Alexis Lacout, Emmanuel Chamorey, Juliette Thariat, Mostafa El Hajjam, Carole Chevenet, Renaud Schiappa, Pierre Yves Marcy
Introduction: This study aimed at comparing thyroid cancer staging when taking into account the differences between the "T" assessment" using ultrasound (US) and histopathological measurements. Material and Methods: This retrospective study included all consecutive differentiated follicular thyroid cancer (DTC) and medullary thyroid cancer (MTC) patients who underwent postoperative histopathological staging assessment at a single institution. Anaplastic thyroid carcinomas were excluded from the present study...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29234267/incidental-detection-of-occult-thyroid-carcinoma-with-11c-choline-pet-ct-for-high-risk-prostate-cancer
#7
Adama Ouattara, Tiago Ribeiro de Oliveira, Serge Holz, Hannes Van den Bossche, David Strybol, Christophe Assenmacher, Wouter Everaerts, Gert De Meerleer, Steven Joniau
We report a case of a 65-year-old male patient with high-risk prostate cancer, re-staged with 11C-choline positron emission tomography/computed tomography (PET/CT) for prostate specific antigen recurrences 3 years after radical prostatectomy and adjuvant radiation therapy. In addition to 2 suspicious presacral lymph nodes which were resected and proven to be metastatic, PET/CT revealed a very high uptake in a calcified thyroid nodule. Evaluation with fine needle aspiration was suspicious for thyroid carcinoma and the patient underwent total thyroidectomy, confirming a non-metastatic encapsulated follicular variant of papillary thyroid carcinoma...
November 2017: Current Urology
https://www.readbyqxmd.com/read/29221164/inhibition-of-x-linked-inhibitor-of-apoptosis-protein-suppresses-tumorigenesis-and-enhances-chemosensitivity-in-anaplastic-thyroid-carcinoma
#8
Yao Liu, Bing Zhang, Tiefeng Shi, Huadong Qin
Anaplastic thyroid carcinoma (ATC) is one of the most lethal carcinoma with a poor prognosis; however, molecular mechanisms underlying the aggressiveness of ATC remain unclear. Our goal was to examine the expression of X-linked inhibitor of apoptosis protein (XIAP) in ATC, as well as its role in ATC tumorigenesis. This is a retrospective study of ATC patients from the Second Affiliated Hospital of Harbin Medical University during June 2003 to October 2013. The expression of XIAP in tumor specimens of ATC patients was examined by immunohistochemical staining...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220531/effect-of-age-on-response-to-therapy-and-mortality-in-patients-with-thyroid-cancer-at-high-risk-of-recurrence
#9
Sona Shah, Laura Boucai
Context: Age at diagnosis has been identified as a major determinant of thyroid cancer-specific survival with older patients being at higher risk for mortality, but the association of age with risk of recurrence has not been studied to date. Objective: To examine the effect of patient's age on response to therapy and disease-specific mortality in a cohort of thyroid cancer patients at high-risk of recurrence as defined by the American Thyroid Association (ATA) risk stratification system...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29214321/hemithyroidectomy-for-low-risk-follicular-carcinoma-of-thyroid-results-from-a-regional-hospital
#10
Tam-Lin Chow, Susanna Wai-Yin Tam, Chi-Yee Choi, Wilson Wai-Yin Kwan
INTRODUCTION: Excellent outcome after conservative thyroid surgery for low-risk follicular thyroid carcinoma (FTC) has been reported from highly specialised centres. However, it is uncertain whether similar treatment results can be achieved in low-volume hospitals. METHODS: At our institution, 49 patients with FTC were treated during 1991-2014. Patients with minimally invasive FTC (MIFTC) were usually treated with hemithyroidectomy. The demographic data, pathology, treatment modality and oncological outcomes of these patients were retrospectively evaluated...
December 7, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/29212393/-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-with-focal-spindle-cell-metaplasia
#11
Grégoire Arnoux, Marc Pusztaszeri
"Noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) is a recent reclassification of the encapsulated follicular variant of papillary thyroid carcinoma, which is supposed to reflect its indolent clinical behavior and to prevent overtreatment of patients with this neoplasm. The diagnosis of NIFTP can only be made histologically on the surgical specimen according to specific inclusion and exclusion criteria, which requires the examination of the whole nodule and its capsule. Spindle cell proliferations, especially of follicular cell origin, arising within thyroid follicular neoplasms are very rare and may cause diagnostic difficulties...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29204912/should-subcentimeter-non-invasive-encapsulated-follicular-variant-of-papillary-thyroid-carcinoma-be-included-in-the-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-category
#12
Bin Xu, Nada Farhat, Justine A Barletta, Yin P Hung, Dario de Biase, Gian Piero Casadei, Ayse Mine Onenerk, R Michael Tuttle, Benjamin R Roman, Nora Katabi, Vania Nosé, Peter Sadow, Giovanni Tallini, William C Faquin, Ronald Ghossein
OBJECTIVE: In 2016, non-invasive, well-circumscribed and encapsulated, follicular variant of papillary thyroid carcinoma (NI-EFV PTC) was reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in order to reduce overtreatment of this indolent tumor. However, the study cohort did not include subcentimeter tumors, i.e., papillary thyroid microcarcinoma (mPTC) with NI-EFV morphology, and such lesions are still regarded and staged by most pathologists as microcarcinomas...
December 4, 2017: Endocrine
https://www.readbyqxmd.com/read/29193910/does-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-have-distinctive-features-on-sonography
#13
Tamar C Brandler, Joseph Yee, Fang Zhou, Margaret Cho, Joan Cangiarella, Xiao-Jun Wei, Melissa Yee-Chang, Wei Sun
BACKGROUND: The noninvasive encapsulated follicular variant of papillary carcinoma (nEFVPTC) has recently been reclassified to "noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)," removing this entity from the malignant category. This re-categorization has had major implications for clinical management. NIFTP has overlapping cytohistologic features with papillary thyroid carcinoma (PTC) and with follicular adenomas (FA), but sonographic data comparing NIFTP to PTC and FA is lacking...
November 29, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29193839/implementing-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-may-potentially-impact-the-risk-of-malignancy-for-thyroid-nodules-categorized-as-aus-flus-and-fn-sfn
#14
Weihong Li, Andrew Sciallis, Madelyn Lew, Judy Pang, Xin Jing
BACKGROUND: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) has recently been reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Implementation of the new terminology may alter the implied risk of malignancy (ROM) across the six categories of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). METHODS: The study cohort consisted of thyroid fine needle aspiration (FNA) cases which were assessed between January 2011 and June 2016 and led to surgical resections...
November 30, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29178507/is-doppler-ultrasonography-of-value-for-the-differentiation-between-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-and-invasive-encapsulated-follicular-variant-of-papillary-thyroid-carcinoma-iefvptc
#15
Pedro Weslley Rosario
Recently, the noninvasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) received the name "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) and was no longer considered "cancer".1 Furthermore, the treatment recommendations for differentiated thyroid cancer no longer apply to NIFTP, which is sufficiently treated by lobectomy only.1 The probability that a thyroid nodule corresponds to NIFTP has become of great interest in clinical practice, since it would at least influence the extent of surgery...
November 25, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29169802/akt-activity-is-elevated-in-aggressive-thyroid-neoplasms-where-it-promotes-proliferation-and-invasion
#16
Daniel R Matson, Heather Hardin, Darya Buehler, Ricardo V Lloyd
The PI3K/AKT/mTOR signaling pathway controls major cellular processes such as cell growth, proliferation and survival. Stimulation of this pathway leads to AKT phosphorylation and activation, resulting in phosphorylation of mTOR and myriad other targets. AKT upregulation has been implicated in thyroid cancer pathogenesis and is a candidate treatment target for patients with advanced disease that has not responded to traditional therapies. Here we evaluate a large series of benign and malignant thyroid tumors for AKT activity and intracellular distribution...
November 20, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29165886/pre-operative-features-of-non-invasive-follicular-thyroid-neoplasms-with-papillary-like-nuclear-features-an-analysis-of-their-cytological-gene-expression-classifier-and-sonographic-findings
#17
S J Song, V A LiVolsi, K Montone, Z Baloch
OBJECTIVE: To investigate the corresponding cytological diagnoses, Gene Expression Classifier (GEC) results and ultrasound features of thyroid nodules diagnosed as non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), as well as any coexisting pathology. METHODS: We performed a retrospective review of thyroid nodules histologically diagnosed as NIFTP at our institution between 1st April 2016 and 1st April 2017. The following data points were collected: demographics, nodule size, ultrasound features, cytological diagnosis, GEC results, origin of sample (in-house vs outside hospital) and any additional pathology identified in the resection specimen...
December 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29163685/expression-of-cancer-testis-antigens-mage-a-mage-c1-gage-and-ctag1b-in-benign-and-malignant-thyroid-diseases
#18
Daniel Hardy Melo, Rui Celso Martins Mamede, Luciano Neder, Wilson Araújo Silva, Mateus Camargo Barros-Filho, Luiz Paulo Kowalski, Clóvis Antonio Lopes Pinto, Marco Antônio Zago, David Livingstone Alves Figueiredo, Achim A Jungbluth
Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. The expression levels of melanoma-associated antigen (MAGE) A, MAGE-C1/CT7, cancer/testis antigen 1B (CTAG1B) and G antigen (GAGE) were analyzed by immunohistochemistry...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29151906/hbme-1-expression-in-differentiated-thyroid-carcinoma-and-its-correlation-with-the-ultrasonic-manifestation-of-thyroid
#19
Jiwei Qiao, Chunyu Li, Yuying Zhang, Shuangyan Wang, Shan Gao
We investigated expression of the protein human bone marrow endothelial cell marker-1 (HBME-1) in differentiated thyroid carcinoma tissues, and analyzed its correlation with ultrasonic manifestation of thyroid. The immunohistochemistry (IHC) staining method was used to measure the expression of HBME-1 in patient with nodular goiter (control group), papillary differentiated thyroid carcinoma (papillary carcinoma group) and follicular differentiated thyroid carcinoma (follicular carcinoma group) to investigate the differences in expression of HBME-1...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29146229/evaluating-the-projected-surgical-impact-of-reclassifying-noninvasive-encapsulated-follicular-variant-of-papillary-thyroid-cancer-as-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features
#20
Rajshri Mainthia, Heather Wachtel, Yufei Chen, Elizabeth Mort, Sareh Parangi, Peter M Sadow, Carrie C Lubitz
BACKGROUND: The reclassification of noninvasive encapsulated follicular variant of papillary thyroid cancer to noninvasive follicular thyroid neoplasm with papillary-like nuclear features will reduce nonefficacious and potentially harmful care. Reclassification is estimated in 18.6% of patients with papillary thyroid carcinoma; we aimed to quantify the implications of this change. METHODS: Pathology reports from April 2006 to April 2016 were reviewed to isolate cases that would have been designated as neoplasm with papillary-like nuclear features...
November 13, 2017: Surgery
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