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Follicular Thyroid Carcinoma

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https://www.readbyqxmd.com/read/29025986/-18-f-fluorodeoxyglycose-avid-thyroid-incidentalomas-the-importance-of-contextual-interpretation
#1
David A Pattison, Michael Bozin, Alexandra Gorelik, Michael S Hofman, Rodney J Hicks, Anita Skandarajah
Background: FDG-avid thyroid incidentalomas (TI) are seen in approximately 2.5% of patients imaged for staging or response assessment of malignancy and represent thyroid cancer in approximately 35% of cases. Consequently, the 2015 ATA guidelines strongly recommend investigation of all FDG-avid nodules ≥1cm with US and fine needle aspiration cytology (FNA). This study aims to assess the overall and thyroid cancer specific survival in a large cohort of patients with FDG-avid TI with long-term follow-up to assess the validity of this approach...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29024469/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-in-the-pediatric-age-group
#2
Esther Diana Rossi, Swati Mehrotra, Ayse Irem Kilic, Iclal Erdem Toslak, Jennifer Lim-Dunham, Maurizio Martini, Guido Fadda, Celestino Pio Lombardi, Luigi Maria Larocca, Güliz A Barkan
BACKGROUND: The most common malignant thyroid neoplasm in children is papillary thyroid carcinoma (PTC). In 2015, the Endocrine Pathology Society introduced the terminology "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) to replace the noninvasive follicular variant of PTC. The objective of the current study was to evaluate previously diagnosed PTC in the pediatric population, reappraise it for NIFTP, and discuss the impact of NIFTP on the risk of malignancy (ROM) for each The Bethesda System for Reporting Thyroid Cytopathology category in the pediatric population...
October 12, 2017: Cancer
https://www.readbyqxmd.com/read/29023564/large-%C3%A2-3cm-thyroid-nodules-with-benign-cytology-can-thyroid-imaging-reporting-and-data-system-tirads-help-predict-false-negative-cytology
#3
Se Jin Nam, Jin Young Kwak, Hee Jung Moon, Jung Hyun Yoon, Eun-Kyung Kim, Ja Seung Koo
BACKGROUND: There is controversy about the accuracy of the fine-needle aspiration (FNA) cytology results in large sized thyroid nodules. Our aim was to evaluate the false-negative rate of FNA for large thyroid nodules and the usefulness of the Thyroid Imaging Reporting and Data System (TIRADS) in predicting false-negative cytology for large thyroid nodules with benign cytology. METHODS: 632 thyroid nodules larger than or equal to 3cm in size with subsequent benign cytology on US-guided FNA were included...
2017: PloS One
https://www.readbyqxmd.com/read/29022643/the-efficiency-of-elastography-in-the-diagnostics-of-follicular-lesions-and-nodules-with-an-unequivocal-fna-result
#4
Martyna Wojtaszek-Nowicka, Dorota Słowińska-Klencka, Stanisław Sporny, Bożena Popowicz, Krzysztof Kuzdak, Lech Pomorski, Krzysztof Kaczka, Jan Sopiński, Mariusz Klencki
INTRODUCTION: The aim was to assess the usefulness of strain elastography (SEG) in the diagnostics of two groups of thyroid nodules (TNs): follicular lesions (FL) with low malignancy risk (< 20.0%) and low percentage of papillary carcinomas (PTCs) among cancers as well as TNs with unequivocal cytology (UC) and high percentage of PTCs among cancers. MATERIAL AND METHODS: 168 TNs were analysed and eventually surgically treated: 100 UC (50 benign and 50 malignant - 90...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29020892/are-evidence-based-guidelines-reflected-in-clinical-practice-an-analysis-of-prospectively-collected-data-of-the-italian-thyroid-cancer-observatory-itco-1
#5
Livia Lamartina, Cosimo Durante, Giuseppe Lucisano, Giorgio Grani, Rocco Alfonso Bellantone, Celestino Pio Lombardi, Alfredo Pontecorvi, Emanuela Arvat, Francesco Felicetti, Maria Chiara Zatelli, Roberta Rossi, Efisio Puxeddu, Silvia Morelli, Massimo Torlontano, Umberto Crocetti, Teresa Montesano, Raffaele Giubbini, Fabio Orlandi, Gianluca Aimaretti, Fabio Monzani, Marco Attard, Cecilia Francese, Alessandro Antonelli, Paolo P Limone, Ruth Rossetto, Laura Fugazzola, Domenico Meringolo, Rocco Bruno, Salvatore Tumino, Graziano Ceresini, Marco Centanni, Salvatore Monti, Domenico Salvatore, Caterina Mian, Giovanna Spiazzi, Luca Persani, Daniele Barbaro, Antonio Nicolucci, Sebastiano Filetti
OBJECTIVES: The goal of evidence-based practice guidelines is to optimize the management of emerging diseases, such as differentiated thyroid cancer (DTC). The aim of this study was to assess therapeutic approaches for DTC in Italy and to see how closely these practices conformed to those recommended in the 2009 American Thyroid Association (ATA) guidelines. METHODS: The Italian Thyroid Cancer Observatory (ITCO) was established to prospectively collect data on thyroid cancers consecutively diagnosed in participating centers (uniformly distributed across the nation)...
October 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29019888/an-upper-cervical-cord-compression-secondary-to-occult-follicular-thyroid-carcinoma-metastases-successfully-treated-with-multiple-radioiodine-therapies-a-clinical-case-report
#6
Ping Dong, Ni Chen, Lin Li, Rui Huang
RATIONALE: The spine is the most common site of bone metastases due to thyroid cancer; however, spinal cord compression as a complication of metastatic thyroid cancer is very rare. PATIENT CONCERNS: A 48-year-old female patient was presented to the Neurosurgical Department, complaining of progressive back neck pain with bilateral upper extremities numbness and weakness for 4 months. DIAGNOSIS: Imaging studies revealed osteolytic destruction in bodies and accessories of the second and third cervical vertebrae with a huge soft-tissue mass compressing spinal cord and causing swelling...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28994272/programmed-death-ligand-1-expression-and-its-correlation-with-lymph-node-metastasis-in-papillary-thyroid-carcinoma
#7
Hyo Jung An, Gyung Hyuck Ko, Jeong-Hee Lee, Jong Sil Lee, Dong Chul Kim, Jung Wook Yang, Min Hye Kim, Jin Pyeong Kim, Eun Jung Jung, Dae Hyun Song
Background: The immunotherapeutic role of programmed death-ligand 1 (PD-L1) in life expectancy in many cancers has been highlighted. However, data regarding PD-L1 expression in papillary thyroid carcinoma (PTC) are limited. In this study, we describe the PD-L1 and programmed cell death protein 1 (PD-1) expressions in PTC and analyze their correlation with lymph node (LN) metastasis. Materials and Methods: Clinicopathological data were obtained from 116 patients with PTC who were treated in Gyeongsang National University Hospital, Jinju, Korea in 2009...
October 3, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28993239/regulation-of-nadph-oxidase-nox4-by-delta-iodolactone-il-%C3%AE-in-thyroid-cancer-cells
#8
Thomasz Lisa, Romina Oglio, Leonardo Salvarredi, Marina Perona, Luciano Rossich, Silvia Copelli, Mario Pisarev, Guillermo Juvenal
INTRODUCTION: Iodine is not used only by the thyroid to synthesize thyroid hormones but also directly influences a number of thyroid parameters such as thyroid proliferation and function. Several iodinated lipids, biosynthesized by the thyroid, were postulated as intermediaries in the action of iodide. Among these, iodolactone (IL-δ) and 2-iodohexadecanal (2-IHDA) have shown to inhibit several thyroid parameters. The antiproliferative effect of IL-δ is not restricted to the thyroid gland...
October 6, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28986854/altered-epigenetic-mechanisms-in-thyroid-cancer-subtypes
#9
REVIEW
Maryam Zarkesh, Azita Zadeh-Vakili, Fereidoun Azizi, Forough Foroughi, Maziar Mohammad Akhavan, Mehdi Hedayati
Thyroid carcinoma (TC) is the most frequent malignant neoplasm of the endocrine system. Molecular methods for diagnosis of invasive thyroid disease can be effectively adopted. Epigenetic factors play an important role in the diversity patterns of gene expression and the phenotypic and biological characteristics of TC subtypes. We aimed to review epigenetic changes in the main subtypes of TC, along with a presentation of the methods that have examined these changes, and active clinical trials for the treatment of advanced TCs targeting epigenetic changes...
October 6, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28982296/shear-wave-elastography-in-thyroid-nodules-with-indeterminate-cytology-results-of-a-prospective-bicentric-study
#10
Stéphane Bardet, Renaud Ciappuccini, Claire Pellot-Barakat, Hervé Monpeyssen, Jean-Jacques Michels, Frédérique Tissier, David Blanchard, Fabrice Menegaux, Dominique De Raucourt, Muriel Lefort, Yves Reznik, Agnes Rouxel, Natacha Heutte, Frédérique Brenac, Alexandra Leconte, Camille Buffet, Bénédicte Clarisse, Laurence Leenhardt
BACKGROUND: The clinical management of thyroid nodules with indeterminate cytology (IC) remains challenging. The role of shear wave elastography (SWE) in this setting is controversial. The aim of the study was to assess the performances of SWE in terms of prediction of malignancy, reproducibility, and combined analysis with ultrasound (US) examination in thyroid nodules with IC. METHODS: This prospective study was conducted in two referral centers. Eligible patients had a thyroid nodule ≥15 mm with IC (Bethesda class III to V) for which surgery had been recommended...
October 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28978070/abi3-a-component-of-the-wave2-complex-is-potentially-regulated-by-pi3k-akt-pathway
#11
Lais Moraes, Nilson I T Zanchin, Janete M Cerutti
We previously reported that ABI3 expression is lost in follicular thyroid carcinomas and its restoration significantly inhibited cell growth, invasiveness, migration, and reduced tumor growth in vivo. The mechanistic basis by which ABI3 exerts its tumor suppressive effects is not fully understood. In this study, we show that ABI3 is a phosphoprotein. Using proteomic array analysis, we showed that ABI3 modulated distinct cancer-related pathways in thyroid cancer cells. The KEA analysis found that PI3K substrates were enriched and forced expression of ABI3 markedly decreased the phosphorylation of AKT and the downstream-targeted protein pGSK3β...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28975450/low-frequency-of-tert-promoter-mutations-in-a-series-of-well-differentiated-follicular-patterned-thyroid-neoplasms
#12
A Proietti, C Sartori, E Macerola, N Borrelli, G Materazzi, P Vitti, F Basolo
The diagnostic and clinical approaches to follicular-patterned thyroid neoplasms often create dilemmas for pathologist and clinicians. The molecular analysis of these tumors could be a useful tool to overcome diagnostic limitations. The most frequent molecular alterations are point mutations of RAS family genes. Nevertheless, other molecular markers should be taken into account for their prognostic role, as BRAF mutations and the recently described telomerase reverse transcriptase (TERT) promoter mutation. We investigated the prevalence and the possible role of TERT promoter, BRAF, and RAS mutations in a series of low-risk well-differentiated follicular-patterned thyroid neoplasms...
October 3, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28974238/cmyc-expression-in-thyroid-follicular-cell-derived-carcinomas-a-role-in-thyroid-tumorigenesis
#13
Hany I Sakr, Deborah J Chute, Christian Nasr, Charles D Sturgis
BACKGROUND: cMYC regulates approximately 15% of human genes and is involved in up to 20% of all human cancers. Reports discussing cMYC protein expression in thyroid carcinomas are limited, with controversies pertaining to cMYC expression patterns noted in the literature. The aims of the current study were to clarify patterns and intensities of cMYC expression in follicular cell-derived thyroid carcinomas across a spectrum of cancer morphologies and disease aggressivities, to correlate cMYC with BRAF(V600E) expression, and to evaluate the potential role of cMYC in progression of well-differentiated thyroid carcinomas into less well-differentiated carcinomas...
October 3, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28971654/-surgical-treatment-of-locally-advanced-well-differentiated-thyroid-carcinoma
#14
Shorook Na'ara, Moran Amit, Salem Billan, Jacob Cohen, Ziv Gil
AIMS: We aimed to better define the most appropriate therapeutic protocol for this type of tumor. BACKGROUND: The incidence of well-differentiated thyroid carcinoma is rising and the mortality from the disease remains low for patients with early disease. Nevertheless, the survival of patients with advanced disease has not improved during the last four decades and a controversy still exists in the literature regarding the optimal treatment in patients with locally advanced (T4) differentiated thyroid carcinoma...
September 2017: Harefuah
https://www.readbyqxmd.com/read/28969135/patterns-of-thyroid-cancers-in-southeastern-nigeria-a-15-year-histopathologic-review-2000-2014
#15
Francis Ikechukwu Ukekwe, Daniel Bankole Olusina, Philip C N Okere
INTRODUCTION: Thyroid Cancer (TC) continues to be the most common endocrine cancer with a worldwide increase in incidence over the last three decades. This trend has been reported in all continents except Africa, where detection is adjudged to be insufficient, making it imperative for us to re-evaluate the patterns in our environment. AIM: To determine the patterns of TCs in Southeastern Nigeria. MATERIALS AND METHODS: This was a 15-year retrospective review of all thyroidectomy specimens received at the Depart-ment of Morbid Anatomy, University of Nigeria, Enugu Campus, Enugu, Nigeria...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28965201/eif1ax-mutation-in-a-patient-with-h%C3%A3-rthle-cell-carcinoma
#16
Michael C Topf, Zi-Xuan Wang, Kevin Furlong, Jeffrey L Miller, Madalina Tuluc, Edmund A Pribitkin
The EIF1AX gene is a novel cancer gene that has been reported in the tumorigenesis of papillary thyroid carcinoma, follicular variant papillary thyroid carcinoma, and anaplastic thyroid carcinoma. A 71-year-old woman presented with a right thyroid mass, which was follicular neoplasm on cytology. The fine needle aspirate of the nodule was examined by next-generation sequencing and found to harbor EIF1AX and TP53 mutations. Right thyroid lobectomy was performed with final pathology showing Hürthle cell carcinoma with capsular and vascular invasion...
September 30, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28964612/management-of-the-central-compartment-in-differentiated-thyroid-carcinoma
#17
Ryan P Goepfert, Gary L Clayman
Management of differentiated thyroid carcinoma (DTC) is gradually evolving with considerations of de-escalation of treatment and/or active surveillance in a significant proportion of patients on the basis of an improved understanding of the long-term disease and functional outcomes from both surgical and non-surgical approaches. This is fueled by improved risk stratification using clinicopathologic prognostic factors as determined through high resolution ultrasound and fine needle aspiration cytology. This paper discusses general recommendations for preoperative decision-making in the management of the central compartment in DTC with particular reference to micropapillary thyroid carcinoma and encapsulated follicular variant papillary thyroid carcinoma...
September 13, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28962946/mitochondrial-dna-common-deletion-in-post-fna-infarcted-oncocytic-thyroid-tumors
#18
Luca Conti, Simona Vatrano, Luca Bertero, Lavinia Masu, Donatella Pacchioni, Lorenzo Daniele, Giovanni De Rosa, Paola Cassoni, Marco Volante, Mauro Papotti
Thyroid fine needle aspiration (FNA) can rarely induce morphological changes potentially hindering the histopathological diagnosis, especially in Hurthle cell tumors (HCT), which may easily undergo post-FNA infarction or necrosis. HCTs contain mitochondrion (mt)-rich cells that may bear mtDNA mutations, the most frequent being the so-called "common deletion" (CD). The aim of this study was to determine the presence and extent of the mtDNA CD in a series of thyroid HCT that underwent extensive infarction following FNA procedure, in comparison with a control series of HCT lacking post-FNA ischemic/hemorrhagic alterations...
September 26, 2017: Human Pathology
https://www.readbyqxmd.com/read/28954751/unilateral-adrenal-mass-as-the-sole-initial-manifestation-of-differentiated-thyroid-cancer
#19
Geethalakshmi Sampathkumar, Arun S Menon, Bindhu M R, Vasantha Nair
Unilateral adrenal metastases without disseminated disease has rarely been reported in differentiated thyroid carcinoma (DTC). A 72-year-old female presented with vague abdominal discomfort and loss of appetite of 2 months duration. She had undergone left hemithyroidectomy for a benign thyroid nodule 18 years ago. A contrast CT of the abdomen showed a large left adrenal mass measuring 11×9 cm, suspicious of adrenocortical carcinoma. Hormonal evaluation was in keeping with a non-functional tumour. The patient underwent left adrenalectomy, histopathology of which revealed metastatic well-differentiated thyroid carcinoma...
September 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28948155/thyroid-like-follicular-carcinoma-of-the-kidney-case-report
#20
Alexandre Cavalcante, André Y Kuwano, André Costa-Matos, Ezequiel F Spanholi, Túlio Souza, Frederico M Mascarenhas
No abstract text is available yet for this article.
November 2017: Urology Case Reports
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