keyword
https://read.qxmd.com/read/38497385/p53-associated-mirnas-repress-lncrna-zfas1-to-retard-the-proliferation-of-papillary-thyroid-carcinoma
#21
JOURNAL ARTICLE
Gang Wang, Liping Wei, Hui Yang
INTRODUCTION: Thyroid carcinoma is the most frequent malignancy among endocrine-related tumours. Papillary thyroid carcinoma (PTC) is the main type of thyroid carcinoma, and almost 80% cases of thyroid carcinoma are diagnosed as PTC. The molecular mechanism underlying PTC progression is unclear. This study aims to investigate the potential mechanisms of zinc finger antisense 1 (ZFAS1) function in PTC. MATERIAL AND METHODS: The expression of ZFAS1 and p53 was determined by quantitative polymerase chain analysis (qPCR) in PTC tissues derived from 20 PTC patients...
2024: Endokrynologia Polska
https://read.qxmd.com/read/38496753/renal-cell-oncocytoma-tumor-evolutions-a-case-report
#22
Alaa Khalid Alduraibi, Noora Bin Essa, Jamshed Bomanji
This report delineates the clinical progression of a renal oncocytoma in a 38-year-old female, initially asymptomatic, over a three-year follow-up period following her treatment for papillary thyroid cancer. The timeline of this case is as follows: In 2016, the patient was treated with total thyroidectomy and I131 for thyroid cancer. During an annual follow-up, an incidental renal mass was detected via FDG PET/CT, initially characterized as a benign, non-FDG-avid renal oncocytoma. Over two years, this lesion demonstrated a remarkable increase in FDG uptake and a slight growth in size, coupled with new I131 uptake in subsequent scans...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38495495/prognostic-significance-of-kif-12-functioning-as-a-tumour-suppressor-in-papillary-thyroid-carcinoma
#23
JOURNAL ARTICLE
Luying Gao, Ruifeng Liu, Yu Xia, Aonan Pan, Xinlong Shi, Liyuan Ma, Jiang Ji, Ya Hu, Xiaoyi Li, Yuang An, Nengwen Luo, Zhiyong Liang, Liangrui Zhou, Yuxin Jiang
Objective: To explore the potential value of a novel marker, KIF-12, in the progression and prognosis of papillary thyroid carcinoma (PTC) through integrative bioinformatics analysis, and clinical sample validation of the prognostic value of KIF-12. Materials and Methods: We extracted the clinicopathological data of 502 PTC patients from The Cancer Genome Atlas-Thyroid Cancer (TCGA-THCA) dataset to identify reliable differentially expressed genes (DEGs) between high and low KIF12 expression groups. Functional enrichment analysis was performed on upregulated DEGs...
2024: Journal of Cancer
https://read.qxmd.com/read/38492235/adiponectin-inhibits-the-progression-of-obesity-associated-papillary-thyroid-carcinoma-through-autophagy
#24
JOURNAL ARTICLE
Changlin Li, Jiao Zhang, Gianlorenzo Dionigi, Nan Liang, Haixia Guan, Hui Sun
BACKGROUND: Obesity is a risk factor for the development of papillary thyroid cancer (PTC). However, the molecular mechanisms by which obesity promotes PTC is unclear. This study aims to identify adipokines that are linked to PTC progression. METHODS: An adipokine antibody array was used to determine the serum levels of 40 adipokines in normal-weight and obese PTC patients. ELISA was used to determine the serum levels of adiponectin. Recombinant human adiponectin was produced by human adipose-derived stem cells (ASCs) and used to treat PTC cells...
March 16, 2024: Endocrinology
https://read.qxmd.com/read/38489728/clinical-responses-to-vemurafenib-in-postoperative-recurrence-of-papillary-thyroid-carcinoma-with-esophageal-fistula-a-case-report
#25
JOURNAL ARTICLE
Sicheng He, Wei Lu, Xun Ding, Jun Zhou, Di Liu, Yang Zhu, Fugang Yang, Zanmei Fu
BACKGROUND: While papillary thyroid carcinoma (PTC) generally exhibits a favorable prognosis post-surgery, the poorly differentiated subtype presents elevated rates of postoperative recurrence. Certain aggressive cases demonstrate invasive behavior, compromising adjacent structures and leading to a poor prognosis. This study delineates a unique case of postoperative PTC recurrence, complicated by esophageal fistula, that showed favorable outcomes following brief Vemurafenib treatment...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38488525/the-inhibition-of-beclin1-dependent-autophagy-sensitizes-ptc-cells-to-abt737-induced-death
#26
JOURNAL ARTICLE
Ning Hu, Yanhua Tian, Yanmei Song, Leilei Zang
ABT737 is used as a specific BCL2 inhibitor, which can treat papillary thyroid carcinoma (PTC). However, the effect of ABT737 on PTC cell apoptosis is limited. Moreover, BCL2 inhibition causes the activation of Beclin1-dependent autophagy. Our study aimed to explore the effects of autophagy and Beclin1 on ABT737 efficacy in PTC. The experimental data showed that ABT737 synchronously enhanced autophagic activity and apoptosis level in PTC cells. ABT737 also promoted the dissociation of BCL2-Beclin1 and BCL2-Bax complexes...
2024: Genetics and Molecular Biology
https://read.qxmd.com/read/38487090/diagnostic-utility-of-ras-mutation-testing-for-refining-cytologically-indeterminate-thyroid-nodules
#27
REVIEW
Isabel R Riccio, Alexandra C LaForteza, Mohammad H Hussein, Joshua P Linhuber, Peter P Issa, Jonathan Staav, Manal S Fawzy, Eman A Toraih, Emad Kandil
RAS mutations are prevalent in indeterminate thyroid nodules, but their association with malignancy risk and utility for diagnosis remains unclear. We performed a systematic review and meta-analysis to establish the clinical value of RAS mutation testing for cytologically indeterminate thyroid nodules. PubMed and Embase were systematically searched for relevant studies. Thirty studies comprising 13,328 nodules met the inclusion criteria. Random effects meta-analysis synthesized pooled estimates of RAS mutation rates, risk of malignancy with RAS positivity, and histologic subtype outcomes...
2024: EXCLI Journal
https://read.qxmd.com/read/38486397/thyroid-cancer-with-cutaneous-metastases
#28
REVIEW
Bao Y Sciscent, Hanel W Eberly, Neerav Goyal, David Goldenberg
Objectives: Thyroid carcinoma with cutaneous metastases is a rare clinical finding. Cutaneous metastases from thyroid carcinoma have been associated with a poor prognosis, but these data are limited to case reports. The exact mechanism of cutaneous metastases from thyroid carcinoma is not clear. Our study aims to report the demographic, clinical, and histologic findings of patients with cutaneous metastases from thyroid carcinoma. Methods: A review was conducted using the Medline/PubMed, Cochrane, and Scopus databases to review literature from inception to May 2023...
March 14, 2024: Ear, Nose, & Throat Journal
https://read.qxmd.com/read/38485895/circnrcam-up-regulates-nrcam-to-promote-papillary-thyroid-carcinoma-progression
#29
JOURNAL ARTICLE
C Wang, Z Wang, L Fu, J Du, F Ji, X Qiu
PURPOSE: Papillary Thyroid Carcinoma (PTC) is the most prevalent subtype of Thyroid Carcinoma (THCA), a type of malignancy in the endocrine system. According to prior studies, Neural Cell Adhesion Molecule (NRCAM) has been found to be up-regulated in PTC and stimulates the proliferation and migration of PTC cells. However, the specific mechanism of NRCAM in PTC cells is not yet fully understood. Consequently, this study aimed to investigate the underlying mechanism of NRCAM in PTC cells, the findings of which could provide new insights for the development of potential treatment targets for PTC...
March 14, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38484463/feasibility-of-active-surveillance-in-patients-with-clinically-t1b-papillary-thyroid-carcinoma-%C3%A2-1-5-cm-in-preoperative-ultrasonography-master-study
#30
JOURNAL ARTICLE
Sang-Hyeon Ju, Yong Bae Ji, Minchul Song, Joung Youl Lim, Da Beom Heo, Min-Gyu Kim, Jae Won Chang, Ho-Ryun Won, Yea Eun Kang, Eu Jeong Ku, Mijin Kim, Eun Kyung Lee, June Young Choi, Hyeong Won Yu, Young Joo Park, Jun-Ho Choe, Bon Seok Koo
OBJECTIVE: Active surveillance (AS) is generally accepted as an alternative to immediate surgery for papillary thyroid carcinoma (PTC) measuring ≤1.0 cm (cT1a) without risk factors. This study investigated the clinicopathologic characteristics of PTCs measuring ≤2.0 cm without cervical lymph node metastasis (cT1N0) by tumor size group to assess the feasibility of AS for PTCs between 1.0 cm and 1.5 cm (cT1b≤1.5). DESIGN: This study enrolled clinically T1N0 patients with preoperative ultrasonography information (N=935) from a cohort of 1259 patients who underwent lobectomy and were finally diagnosed with PTC from June 2020 to March 2022...
March 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38482434/detection-of-thyroglobulin-for-diagnosis-of-metastatic-lateral-cervical-lymph-nodes-in-papillary-thyroid-carcinoma-accuracy-and-application-in-clinical-practice
#31
JOURNAL ARTICLE
Baolin Chen, Zhongliang Yan, Yuxiang Bao, Jiayang Li, Chengmin Luo, Guangxu Yang, Taolang Li, Xiaoming Cheng, Junyuan Lv
BACKGROUND: Accurate assessment of lateral cervical lymph node metastasis (LLNM) involvement is important for treating papillary thyroid carcinoma (PTC). Thyroglobulin is associated with LLNM, but there may be differences in the diagnostic value of serum thyroglobulin (sTg) and fine needle aspiration washout fluid thyroglobulin (FNA-Tg). Herein, we investigated the optimal cutoff value (OCV) of sTg and FNA-Tg and their diagnostic performance. METHODS: We enrolled 116 PTC patients who underwent radical resection of thyroid carcinoma with lateral cervical lymph node dissection at the Affiliated Hospital of Zunyi Medical University from June 2018 to July 2022...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38482163/surgical-complications-in-papillary-thyroid-cancer-patients-with-cervical-lymph-node-metastases
#32
JOURNAL ARTICLE
Minh-Chien Pham, Thang Nguyen, Hong-Phong Nguyen
BACKGROUND: The reported complication rates of neck dissection are not specific patients with papillary thyroid cancer` with metastatic lymph nodes. This study aimed to describe the complication profile of neck dissection and the effect of concurrent lateral neck dissection on complication rates. METHODS: This single-center prospective cohort study analyzed the data of 52 patients who underwent a total thyroidectomy and therapeutic lymph node dissection between March 2021 and March 2023...
2024: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38477417/accuracy-of-world-health-organisation-grade-parameters-necrosis-and-mitotic-activity-and-foci-of-vascular-invasion-in-predicting-prognosis-of-papillary-thyroid-carcinoma-a-case-control-validation-study
#33
JOURNAL ARTICLE
Moira Ragazzi, Giulia Besutti, Pamela Mancuso, Paolo Giorgi Rossi, Alessia Ciarrocchi, Benedetta Donati, Gloria Manzotti, Davide Giordano, Andrea Frasoldati, Federico Chiaruccci, Dario de de Biase, Sara Coluccelli, Thais Maloberti, Antonio De Leo, Simonetta Piana, Giovanni Tallini
AIMS: Tumour necrosis and/or increased mitoses define high-grade papillary thyroid carcinoma (PTC). It is unclear whether angioinvasion is prognostic for PTC. Cut-offs at five or more mitoses/2 mm2 and four or more angioinvasive foci have been empirically defined based upon data from all forms of aggressive non-anaplastic thyroid carcinomas. Performance of tumour necrosis, mitoses and vascular invasion in predicting distant metastases when specifically applied to PTC is undefined...
March 13, 2024: Histopathology
https://read.qxmd.com/read/38476625/correlations-of-m-6-a-methylation-related-lncrnas-with-the-prognosis-of-papillary-thyroid-carcinoma
#34
JOURNAL ARTICLE
Xiang Li, Zigang Ding, Yun Tong
PURPOSE: Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. Recurrence makes the prognosis for some patients with PTC worse. Increasing evidence have suggested that N6-methyladenosine (m6 A) RNA methylation plays an important role in tumorigenesis. However, the significance of m6 A-related lncRNAs in the malignant progression of PTC remains unknown. In this study, we explored the significance of M6 A-related lncrnas in the malignant progression of PTC. PATIENTS AND METHODS: Transcriptome and clinical data of PTC were achieved and integrated from The Cancer Genome Atlas (TCGA)...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38472412/clinicopathological-analysis-of-thyroid-carcinomas-with-the-ret-and-ntrk-fusion-genes-characterization-for-genetic-analysis
#35
JOURNAL ARTICLE
Yoichiro Okubo, Soji Toda, Mei Kadoya, Shinya Sato, Emi Yoshioka, Chie Hasegawa, Kyoko Ono, Kota Washimi, Tomoyuki Yokose, Yohei Miyagi, Katsuhiko Masudo, Hiroyuki Iwasaki, Hiroyuki Hayashi
Thyroid carcinomas exhibit various genetic alterations, including the RET and NTRK fusion genes that are targets for molecular therapies. Thus, detecting fusion genes is crucial for devising effective treatment plans. This study characterized the pathological findings associated with these genes to identify the specimens suitable for genetic analysis. Thyroid carcinoma cases positive for the fusion genes were analyzed using the Oncomine Dx Target Test. Clinicopathological data were collected and assessed. Among the 74 patients tested, 8 had RET and 1 had NTRK3 fusion gene...
March 12, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38470692/are-higher-body-mass-index-and-worse-metabolic-parameters-associated-with-more-aggressive-differentiated-thyroid-cancer-a-retrospective-cohort-study
#36
JOURNAL ARTICLE
Yasmin Abu Arar, Michael Shilo, Natalya Bilenko, Michael Friger, Hagit Marsha, David Fisher, Merav Fraenkel, Uri Yoel
Obesity is a risk factor for differentiated thyroid cancer (DTC), but the association with DTC aggressiveness is controversial. To evaluate the association between preoperative body mass index (BMI)/other metabolic parameters and DTC aggressiveness in our surgical cohort, we retrospectively evaluated patients following thyroid surgery who were diagnosed with DTC between December 2013 and January 2021. Baseline characteristics, histopathological features, treatment modalities, and follow-up data were studied...
March 2, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38467142/divergent-growth-on-18f-fdg-pet-ct-in-a-case-of-co-existing-pulmonary-metastatic-leiomyosarcoma-and-papillary-thyroid-carcinoma
#37
JOURNAL ARTICLE
Sean Ira G Gacula, Sophie C Kunte, Lena M Unterrainer, Johannes RĂ¼benthaler, Wolfgang G Kunz, Clemens Cyran, Adrien Holzgreve
No abstract text is available yet for this article.
March 11, 2024: Nuklearmedizin. Nuclear Medicine
https://read.qxmd.com/read/38463514/machine-learning-based-prediction-of-a-diagnostic-model-using-autophagy-related-genes-based-on-rna-sequencing-for-patients-with-papillary-thyroid-carcinoma
#38
JOURNAL ARTICLE
Lin Chen, Gaofeng Tao, Mei Yang
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer and belongs to the category of malignant tumors of the thyroid gland. Autophagy plays an important role in PTC. The purpose of this study is to develop a novel diagnostic model using autophagy-related genes (ARGs) in patients. In this study, RNA sequencing data of PTC samples and normal samples were obtained from GSE33630 and GSE29265. Then, we analyzed GSE33630 datasets and identified 127 DE-ARGs. Functional enrichment analysis suggested that 127 DE-ARGs were mainly enriched in pathways in cancer, protein processing in endoplasmic reticulum, toll-like receptor pathway, MAPK pathway, apoptosis, neurotrophin signaling pathway, and regulation of autophagy...
2024: Open Medicine (Warsaw, Poland)
https://read.qxmd.com/read/38461879/follow-up-and-outcomes-of-186-patients-with-follicular-cell-derived-thyroid-cancer-seen-at-a-referral-center-by-one-thyroidologist-in-2015
#39
JOURNAL ARTICLE
Vahab Fatourechi
OBJECTIVE: To study the profile, management, and outcomes of follicular cell-derived thyroid cancer (FCDTC) before publication of the 2016 American Thyroid Association guidelines recommending less aggressive thyroid cancer procedures. METHODS: Patients with FCDTC were seen by one thyroidologist at Mayo Clinic during the 2015 calendar year. Patients underwent surgical procedures for FCDTC in 2015 or earlier at the Mayo Clinic or another institution. Follow-up data were collected from January 1, 2016, through July 20, 2022...
March 8, 2024: Endocrine Practice
https://read.qxmd.com/read/38461693/progress-in-long-non-coding-rnas-as-prognostic-factors-of-papillary-thyroid-carcinoma
#40
REVIEW
Hao-Nan Zhu, Dong-Liang Song, Si-Nan Zhang, Zhao-Jie Zheng, Xing-Yu Chen, Xin Jin
Papillary thyroid carcinoma (PTC) is generally recognized as a slow-growing tumor. However, a small subset of patients may still experience relapse or metastasis shortly after therapy, leading to a poor prognosis and raising concerns about excessive medical treatment. One major challenge lies in the inadequacy of effective biomarkers for accurate risk stratification. Long non-coding RNAs (lncRNAs), which are closely related to malignant characteristics and poor prognosis, play a significant role in the genesis and development of PTC through various pathways...
February 27, 2024: Pathology, Research and Practice
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