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Cardiac surgery , heart valve disease , mechanical valve , coronary surgery , aortic surgery ,

Lucio Barile, Elisabetta Cervio, Vincenzo Lionetti, Giuseppina Milano, Alessandra Ciullo, Vanessa Biemmi, Sara Bolis, Claudia Altomare, Marco Matteucci, Dario Disilvestre, Tudor Emanuel Fertig, Tiziano Torre, Stefanos Demertzis, Pierluigi Mauri, Tiziano Moccetti, Giuseppe Vassalli
Aims: Cell therapy trials using cardiac-resident progenitor cells (CPCs) and bone marrow-derived mesenchymal stem/progenitor cells (BMCs) in patients after myocardial infarction have provided encouraging results. Exosomes, nanosized extracellular vesicles of endosomal origin, figure prominently in the bioactivities of these cells. However, a head-to-head comparison of exosomes from the two cell types has not been performed yet. Methods and Results: CPCs and BMCs were derived from cardiac atrial appendage specimens and sternal bone marrow, respectively, from patients (n=20; age, 69...
March 5, 2018: Cardiovascular Research
Juan Lacalzada-Almeida, Alejandro De la Rosa-Hernández, María Manuela Izquierdo-Gómez, Javier García-Niebla, Iván Hernández-Betancor, Juan Alfonso Bonilla-Arjona, Antonio Barragán-Acea, Ignacio Laynez-Cerdeña
A 61-year-old male with a prosthetic St Jude aortic valve size 24 presented with heart failure symptoms and minimal-effort angina. Eleven months earlier, the patient had undergone cardiac surgery because of an aortic root dilatation and bicuspid aortic valve with severe regurgitation secondary to infectious endocarditis by Coxiela burnetii and coronary artery disease in the left circumflex coronary artery. Then, a prosthesis valve and a saphenous bypass graft to the left circumflex coronary artery were placed...
2018: Clinical Interventions in Aging
Walter J Gomes, Rita Simone Moreira, Alexandre Cabral Zilli, Luiz Carlos Bettiati, Fernando Augusto Marinho Dos Santos Figueira, Stephanie Steremberg Pires D' Azevedo, Marcelo José Ferreira Soares, Marcio Pimentel Fernandes, Roberto Vito Ardito, Renata Andrea Barberio Bogdan, Valquíria Pelisser Campagnucci, Diana Nakasako, Renato Abdala Karam Kalil, Clarissa Garcia Rodrigues, Anilton Bezerra Rodrigues, Marcelo Matos Cascudo, Fernando Antibas Atik, Elson Borges Lima, Vinicius José da Silva Nina, Renato Albuquerque Heluy, Lisandro Gonçalves Azeredo, Odilon Silva Henrique, José Teles de Mendonça, Katharina Kelly de Oliveira Gama Silva, Marcelo Pandolfo, José Dantas de Lima, Renato Max Faria, Jonas Pereira Dos Santos, Rodrigo Pereira Paez, Guilherme Henrique Biachi Coelho, Sergio Nunes Pereira, Roberta Senger, Enio Buffolo, Guido Marco Caputi, José Amalth do Espírito Santo, Juliana Aparecida Borges de Oliveira, Otavio Berwanger, Alexandre Biasi Cavalcanti, Fabio B Jatene
Objective: To report the early results of the BYPASS project - the Brazilian registrY of adult Patient undergoing cArdiovaScular Surgery - a national, observational, prospective, and longitudinal follow-up registry, aiming to chart a profile of patients undergoing cardiovascular surgery in Brazil, assessing the data harvested from the initial 1,722 patients. Methods: Data collection involved institutions throughout the whole country, comprising 17 centers in 4 regions: Southeast (8), Northeast (5), South (3), and Center-West (1)...
March 2017: Brazilian Journal of Cardiovascular Surgery
Nikhil Narang, Roberto M Lang, Vladimir M Liarski, Valluvan Jeevanandam, Marion A Hofmann Bowman
A 55-year-old man with a history of erosive, seropositive rheumatoid arthritis (RA), and interstitial lung disease presented with shortness of breath. Echocardiography showed new-onset severe left ventricular (LV) dysfunction with an ejection fraction (EF) of 15% and moderately increased mean aortic valve gradient of 20 mmHg in a trileaflet aortic valve with severe sclero-calcific degeneration. Coronary angiography revealed no significant obstructive coronary disease. Invasive hemodynamic studies and dobutamine stress echocardiography were consistent with moderate aortic stenosis...
2017: Frontiers in Cardiovascular Medicine
Nisharahmed Kherada, Juan Carlos Brenes, Annapoorna S Kini, George D Dangas
Accurate evaluation of trans-aortic valvular pressure gradients is challenging in cases where dual mechanical aortic and mitral valve prostheses are present. Non-invasive Doppler echocardiographic imaging has its limitations due to multiple geometric assumptions. Invasive measurement of trans-valvular gradients with cardiac catheterization can provide further information in patients with two mechanical valves, where simultaneous pressure measurements in the left ventricle and ascending aorta must be obtained...
March 15, 2017: Catheterization and Cardiovascular Interventions
Weichao Liu, Fei He, Gongning Shi
OBJECTIVE: To analyze the success rates and prognosis of heart valvuloplasty and valve replacement for elderly patients, and to provide clinical evidence. METHODS: A total of 1240 patients who received heart valve surgeries in our hospital from June 2004 to October 2014 were selected and retrospectively analyzed. They were divided into two groups based on age (60), and those older than 60 (Group B) suffered from rheumatic valvular heart disease and nonrheumatic valvular heart disease including degenerative valve disease...
September 2015: Pakistan Journal of Medical Sciences Quarterly
Heidi M Connolly, Hartzell V Schaff, Martin D Abel, Joseph Rubin, J Wells Askew, Zhuo Li, Jacob J Inda, Sushil A Luis, Rick A Nishimura, Patricia A Pellikka
BACKGROUND: Symptoms and survival of patients with carcinoid syndrome have improved, but development of carcinoid heart disease (CaHD) continues to decrease survival. OBJECTIVES: This study aimed to analyze patient outcomes after valve surgery for CaHD during a 27-year period at 1 institution to determine early and late outcomes and opportunities for improved patient care. METHODS: We retrospectively studied the short-term and long-term outcomes of all consecutive patients with CaHD who underwent valve replacement at our institution between 1985 and 2012...
November 17, 2015: Journal of the American College of Cardiology
Piotr Duchnowski, Piotr Szymański, Ewa Orłowska-Baranowska, Mariusz Kuśmierczyk, Tomasz Hryniewiecki
BACKGROUND AND AIM: Several studies have reported that elevated red cell distribution width (RDW) is associated with poor outcomes in patients with coronary artery disease, chronic heart failure and aortic stenosis following transcatheter aortic valve replacement. Their prognostic utility in patients undergoing aortic valve replacement (AVR) surgery is unknown. METHODS: We prospectively evaluated the prognostic value of RDW in a group of 191 consecutive patients with severe symptomatic aortic stenosis undergoing AVR...
2016: Kardiologia Polska
Jeffrey Shuhaiber, Abby J Isaacs, Art Sedrakyan
BACKGROUND: We aimed to determine the relationship between hospital volume and use of dual aortic and mitral valve surgical procedures. METHODS: Patients who underwent both aortic and mitral valve repair or replacement during the same hospital stay were identified from the Nationwide Inpatient Sample (NIS). We compared patients' characteristics and in-hospital outcomes by the average annual center volume for multiple-heart valve surgical procedures, grouped into tertiles of patients with low (1 to 8), medium (9 to 18), and high (19+) volume categories using χ(2) tests and adjusted hierarchical logistic regression models...
October 2015: Annals of Thoracic Surgery
Philip A Kramer, Balu K Chacko, Saranya Ravi, Michelle S Johnson, Tanecia Mitchell, Stephen Barnes, Alireza Arabshahi, Louis J Dell'Italia, David J George, Chad Steele, James F George, Victor M Darley-Usmar, Spencer J Melby
Atherosclerosis and valvular heart disease often require treatment with corrective surgery to prevent future myocardial infarction, ischemic heart disease, and heart failure. Mechanisms underlying the development of the associated complications of surgery are multifactorial and have been linked to inflammation and oxidative stress, classically as measured in the blood or plasma of patients. Postoperative pericardial fluid (PO-PCF) has not been investigated in depth with respect to the potential to induce oxidative stress...
February 2015: Laboratory Investigation; a Journal of Technical Methods and Pathology
Pilar Tornos
There are very few studies on valvular heart disease in women. There is a sex influence in the prevalence of some types of valve disease: it is well known that rheumatic mitral stenosis is very common in women but degenerative valve disease affects both sexes in a similar way. In degenerative aortic stenosis several physiopathological differences have been reported in women: the amount of calcium is lower than in men and the left ventricle generates higher gradients and hypercontractile response in women. Regarding prognosis it is well accepted that women have higher mortality rates than men in cardiac surgery, both in coronary surgery and in valvular surgery...
2006: Revista Española de Cardiología
Olaf Stanger, Thomas Schachner, Brigitta Gahl, Peter Oberwalder, Lars Englberger, Markus Thalmann, Debbie Harrington, Dominik Wiedemann, Michael Südkamp, Mary N Sheppard, Mark Field, Bartosz Rylski, Mario Petrou, Thierry Carrel, Johannes Bonatti, John Pepper
BACKGROUND: Cardiac surgery with cardiopulmonary bypass is associated with mechanical manipulation of the ascending aorta that occasionally leads to type A aortic dissection (AAD). METHODS AND RESULTS: One hundred three patients with surgical repair for AAD following nonaortic cardiac surgery were identified. With the use of logistic regression modeling, coronary artery bypass surgery (CABG), either isolated or combined with another procedure in the initial operation, was associated with significantly higher operative mortality in comparison with patients with non-CABG procedures at the time of AAD repair both for all patients (odds ratio, 2...
October 8, 2013: Circulation
Yves d'Udekem, Javariah Siddiqui, Cameron S Seaman, Igor E Konstantinov, John C Galati, Michael M H Cheung, Christian P Brizard
OBJECTIVES: To determine rate of reoperation subsequent to primary valve repair in a pediatric population. METHODS: Between 1996 and 2009, 142 consecutive patients underwent aortic valve repair in our institution. Median age at surgery was 9 years, with 30 being younger than age 1 year. Indication for surgery was stenosis (n = 76), regurgitation (n = 55), and both (n = 11). Forty-six patients underwent repair with no addition of patch, whereas 96 patients required addition of patches of glutaraldehyde preserved autologous pericardium for cusp extension (n = 51) and other repair (n = 45)...
February 2013: Journal of Thoracic and Cardiovascular Surgery
Katarzyna Baranowska, Grzegorz Juszczyk, Iwona Dmitruk, Małgorzata Knapp, Agnieszka Tycińska, Piotr Jakubów, Anna Adamczuk, Adrian Stankiewicz, Tomasz Hirnle
BACKGROUND: Postoperative complications are integral to cardiac surgery. The most serious ones are stroke, which develops in about 7.5% of the patients, and postoperative encephalopathy, which affects 10-30% of the patients. According to bibliographical data, the number of complications is increasing. AIM: To analyse the risk factors and the types of neurological complications in patients undergoing heart surgery. METHODS: We assessed retrospectively 323 consecutive patients undergoing surgery at the Department of Cardiac Surgery, University Teaching Hospital, Medical University of Bialystok, Poland, between July 2007 and June 2008...
2012: Kardiologia Polska
Mahmood Shirzad, Abbasali Karimi, Seyed Hossein Ahmadi, Mehrab Marzban, Mokhtar Tazik, Hermineh Aramin
BACKGROUND: During last decades mechanical ventilation has been an important support in the postoperative management of patients undergoing cardiac surgery. This study was designed to determine the predictors of prolonged mechanical ventilation (PMV) in patients undergoing heart valve surgery. METHODS: This retrospective study considered of 1056 patients who underwent isolated valve surgery at Tehran Heart Center from March 2002 to March 2009. PMV is considered as mechanical ventilation period of > or =24 hours at postoperative hospital stay in this study...
March 2010: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Ren Wang, Li-Zhong Sun, Xiao-Peng Hu, Wei-Guo Ma, Qian Chang, Jun-Ming Zhu, Yong-Min Liu, Cun-Tao Yu
BACKGROUND: Coarctation of the aorta with cardiac lesions or complex coarctation is a formidable challenge for cardiac surgeons. Extra-anatomic bypass allows simultaneous intracardiac repair or an alternative approach for patients with complex coarctation. METHODS: Between July 1997 and March 2008, 43 patients with coarctation of the aorta underwent extra-anatomic bypass grafting, including 10 ascending-to-descending aorta bypasses and 33 ascending aorta-to-infrarenal abdominal aorta bypasses...
May 2010: Journal of Vascular Surgery
Manjula Maganti, Mitesh Badiwala, Amir Sheikh, Hugh Scully, Christopher Feindel, Tirone E David, Vivek Rao
BACKGROUND: Low cardiac output syndrome is defined as the need for a postoperative intra-aortic balloon pump or inotropic support for longer than 30 minutes in the intensive care unit. Mitral valve surgery is increasingly being performed in high-risk patients who might require mechanical circulatory support for low cardiac output syndrome. Therefore the aim of this study was to identify the preoperative predictors of low cardiac output syndrome after mitral valve surgery. METHODS: We conducted a retrospective review of data prospectively entered into an institutional database...
October 2010: Journal of Thoracic and Cardiovascular Surgery
B Gerber
Recent technical improvements have allowed to non-invasive cardiac imaging by Multidetector CT. (MDCT). In initial work we compared the value of successive generations of MDCT (4, 16, and 64 slice) for non-invasive imaging of coronary arteries vs. non-invasive magnetic resonance coronary angiography using conventional coronary angiography as gold standard. Our work demonstrated progressive improvement of diagnostic accuracy from 4 to 64 slice MDCT technology. The most recent generation of 64 slice MDCT became more performing than MRI...
2009: Bulletin et Mémoires de L'Académie Royale de Médecine de Belgique
Ardawan Julian Rastan, Andreas Dege, Matthias Mohr, Nicolas Doll, Volkmar Falk, Thomas Walther, Friedrich Wilhelm Mohr
OBJECTIVE: Adult postcardiotomy cardiogenic shock potentially requiring mechanical circulatory support occurs in 0.5% to 1.5% of cases. Risk factors influencing early or long-term outcome after extracorporeal membrane oxygenation implantation are not well described. METHODS: Between May 1996 and May 2008, 517 adult patients received extracorporeal membrane oxygenation support for postcardiotomy cardiogenic shock. Procedures were isolated coronary artery bypass grafting (37...
February 2010: Journal of Thoracic and Cardiovascular Surgery
Aron-Frederik Popov, Kasim Oguz Coskun, Theodor Tirilomis, Jan Dieter Schmitto, José Hinz, Thomas Kriebel, Friedrich Albert Schoendube, Wolfgang Ruschewski
Due to improved outcome after surgery for congenital heart defects, children, adolescents, and grown-ups with congenital heart defects become an increasing population. In order to evaluate operative risk and early outcome after mechanical aortic valve replacement (AVR) in this population, we reviewed patients who underwent previous repair of congenital heart defects. Between July 2002 and November 2008, 15 (10 male and 5 female) consecutive patients (mean age 14.5 +/- 10.5 years) underwent mechanical AVR. Hemodynamic indications for AVR were aortic stenosis in four (27%), aortic insufficiency in eight (53%), and mixed disease in three (20%) after previous repair of congenital heart defects...
November 2009: Artificial Organs
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