Bing Chen, W H Wilson Tang, Mario Rodriguez, Kathleen E Corey, Arun J Sanyal, Patrick S Kamath, Biykem Bozkurt, Hafeez Ul Hassan Virk, Gregg S Pressman, Jeffrey V Lazarus, Hashem B El-Serag, Chayakrit Krittanawong
Nonalcoholic fatty liver disease (NAFLD) and cardiovascular diseases are both highly prevalent conditions around the world, and emerging data have shown an association between them. This review found several longitudinal and cross-sectional studies showing that NAFLD was associated with coronary artery disease, cardiac remodeling, aortic valve remodeling, mitral annulus valve calcifications, diabetic cardiomyopathy, diastolic cardiac dysfunction, arrhythmias, and stroke. Although the specific underlying mechanisms are not clear, many hypotheses have been suggested, including that metabolic syndrome might act as an upstream metabolic defect, leading to end-organ manifestations in both the heart and liver...
November 2022: Seminars in Liver Disease