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RANDOMIZED CONTROLLED TRIAL
Keir E J Philip, Sara C Buttery, Sarah Bowen, Adam Lewis, Edmund Jeffery, Saeed M Alghamdi, Parris Williams, Ali M Alasmari, Abdullah S Alsulayyim, Christopher M Orton, Francesca Conway, Ley Chan, Bavithra Vijayakumar, Anand Tana, James Tonkin, Alexis Perkins, Justin L Garner, Karthikan Srikanthan, Ahmed Sadaka, Matthew J Pavitt, Winston Banya, Adam Lound, Sarah Elkin, Michael I Polkey, William D-C Man, Keir Lewis, Phoene Cave, Daisy Fancourt, Nicholas S Hopkinson
BACKGROUND: Singing for lung health (SLH) is an arts-based breathing control and movement intervention for people with long-term respiratory conditions, intended to improve symptoms and quality of life. Online, remotely delivered programmes might improve accessibility; however, no previous studies have assessed the effectiveness of this approach. METHODS: We conducted an assessor-blind randomised controlled trial comparing the impact of 12 weeks of once-weekly online SLH sessions against usual care on health-related quality of life, assessed using the RAND 36-Item Short Form Health Survey (SF-36) Mental Health Composite (MHC) and Physical Health Composite (PHC) scores...
May 2, 2024: BMJ Open Respiratory Research
#22
JOURNAL ARTICLE
Keng Ioi Vong, Sangmoon Lee, Kit Sing Au, T Blaine Crowley, Valeria Capra, Jeremiah Martino, Meade Haller, Camila Araújo, Hélio R Machado, Renee George, Bryn Gerding, Kiely N James, Valentina Stanley, Nan Jiang, Kameron Alu, Naomi Meave, Anna S Nidhiry, Fiza Jiwani, Isaac Tang, Ashna Nisal, Ishani Jhamb, Arzoo Patel, Aakash Patel, Jennifer McEvoy-Venneri, Chelsea Barrows, Celina Shen, Yoo-Jin Ha, Robyn Howarth, Madison Strain, Allison Elizabeth Ashley-Koch, Matloob Azam, Sara Mumtaz, Gyang Markus Bot, Richard H Finnell, Zoha Kibar, Ahmed I Marwan, Gia Melikishvili, Hal S Meltzer, Osvaldo M Mutchinick, David A Stevenson, Henry J Mroczkowski, Betsy Ostrander, Erica Schindewolf, Julie Moldenhauer, Elaine H Zackai, Beverly S Emanuel, Sixto Garcia-Minaur, Beata A Nowakowska, Roger E Stevenson, Maha S Zaki, Hope Northrup, Hanna K McNamara, Kimberly A Aldinger, Ian G Phelps, Mei Deng, Ian A Glass, Bernice Morrow, Donna M McDonald-McGinn, Simone Sanna-Cherchi, Dolores J Lamb, Joseph G Gleeson, Allison Elizabeth Ashley Koch, Hal S Meltzer, Joan Le, Kit Sing Au, Hope Northrup, Gyang Markus Bot, Valeria Capra, Richard H Finnell, Zoha Kibar, Philip J Lupo, Helio R Machado, Camila Araújo, Tony Magana, Ahmed I Marwan, Gia Melikishvili, Osvaldo M Mutchinick, Roger E Stevenson, Anna Yurrita, Maha S Zaki, Sara Mumtaz, José Ramón Medina-Bereciartu, Caroline M Kolvenbach, Shirlee Shril, Friedhelm Hildebrandt, Mahmoud M Noureldeen, Aida Ms Salem, Yukitoshi Takahashi, Hormos Salimi-Dafsari, H Westley Phillips, Brian Hanak, Bülent Kara, Ayfer Sakarya Güneş, David D Gonda, Salman Kirmani, Tinatin Tkemaladze, Joseph G Gleeson
Meningomyelocele is one of the most severe forms of neural tube defects (NTDs) and the most frequent structural birth defect of the central nervous system. We assembled the Spina Bifida Sequencing Consortium to identify causes. Exome and genome sequencing of 715 parent-offspring trios identified six patients with chromosomal 22q11.2 deletions, suggesting a 23-fold increased risk compared with the general population. Furthermore, analysis of a separate 22q11.2 deletion cohort suggested a 12- to 15-fold increased NTD risk of meningomyelocele...
May 3, 2024: Science
#23
JOURNAL ARTICLE
Aleksi J Sihvonen, Anni Pitkäniemi, Sini-Tuuli Siponkoski, Linda Kuusela, Noelia Martínez-Molina, Sari Laitinen, Essi-Reetta Särkämö, Johanna Pekkola, Susanna Melkas, Gottfried Schlaug, Viljami Sairanen, Teppo Särkämö
Singing-based treatments of aphasia can improve language outcomes, but the neural benefits of group-based singing in aphasia are unknown. Here, we set out to determine the structural neuroplasticity changes underpinning group-based singing induced treatment effects in chronic aphasia. Twenty-eight patients with at least mild nonfluent post-stroke aphasia were randomized into two groups that received a 4-month multicomponent singing intervention (singing group) or standard care control group). High-resolution T1-images and multi-shell diffusion-weighted MRI data were collected in two time points (baseline / 5-month)...
April 30, 2024: ENeuro
#24
JOURNAL ARTICLE
Dajia Ye, Justin T Walsh, Ian P Junker, Yun Ding
How evolutionary changes in genes and neurons encode species variation in complex motor behaviors is largely unknown. Here, we develop genetic tools that permit a neural circuit comparison between the model species Drosophila melanogaster and the closely related species D. yakuba, which has undergone a lineage-specific loss of sine song, one of the two major types of male courtship song in Drosophila. Neuroanatomical comparison of song-patterning neurons called TN1 across the phylogeny demonstrates a link between the loss of sine song and a reduction both in the number of TN1 neurons and the neurites supporting the sine circuit connectivity...
April 24, 2024: Current Biology: CB
#25
JOURNAL ARTICLE
Jiaping Hu, Junyi Peng, Zidong Zhou, Tianyun Zhao, Lijie Zhong, Keyan Yu, Kexin Jiang, Tzak Sing Lau, Chuan Huang, Lijun Lu, Xiaodong Zhang
BACKGROUND: Artificial intelligence shows promise in assessing knee osteoarthritis (OA) progression on MR images, but faces challenges in accuracy and interpretability. PURPOSE: To introduce a temporal-regional graph convolutional network (TRGCN) on MR images to study the association between knee OA progression status and network outcome. STUDY TYPE: Retrospective. POPULATION: 194 OA progressors (mean age, 62 ± 9 years) and 406 controls (mean age, 61 ± 9 years) from the OA Initiative were randomly divided into training (80%) and testing (20%) cohorts...
April 30, 2024: Journal of Magnetic Resonance Imaging: JMRI
#26
JOURNAL ARTICLE
Ming-Ling Chang, Jennifer Tai, Jur-Shan Cheng, Wei-Ting Chen, Sien-Sing Yang, Cheng-Hsun Chiu, Rong-Nan Chien
AIM: The response rate to pioglitazone and the predictive factors for its effects on improving liver biochemistry in patients with steatotic liver disease (SLD) remain elusive, so we aimed to investigate these issues. METHODS: A 3-year prospective cohort study of 126 Taiwanese patients with SLD treated with pioglitazone (15-30 mg/day) was conducted. Phospholipase domain-containing protein 3 I148M rs738409, methylenetetrahydrofolate reductase rs1801133, aldehyde dehydrogenase 2 (ALDH2) rs671 and lipoprotein lipase rs10099160 single nucleotide polymorphisms were assessed in the patients...
April 29, 2024: Diabetes, Obesity & Metabolism
#27
JOURNAL ARTICLE
Bo Wang, Zsofia Torok, Alison Duffy, David G Bell, Shelyn Wongso, Tarciso A F Velho, Adrienne L Fairhall, Carlos Lois
Reliable execution of precise behaviors requires that brain circuits are resilient to variations in neuronal dynamics. Genetic perturbation of the majority of excitatory neurons in HVC, a brain region involved in song production, in adult songbirds with stereotypical songs triggered severe degradation of the song. The song fully recovered within 2 weeks, and substantial improvement occurred even when animals were prevented from singing during the recovery period, indicating that offline mechanisms enable recovery in an unsupervised manner...
April 29, 2024: Nature Neuroscience
#28
JOURNAL ARTICLE
Justin C Sing, Joshua Charkow, Mohammed AlHigaylan, Ira Horecka, Leon Xu, Hannes L Röst
With the increased usage and diversity of methods and instruments being applied to analyze Data-Independent Acquisition (DIA) data, visualization is becoming increasingly important to validate automated software results. Here we present MassDash, a cross-platform DIA mass spectrometry visualization and validation software for comparing features and results across popular tools. MassDash provides a web-based interface and Python package for interactive feature visualizations and summary report plots across multiple automated DIA feature detection tools, including OpenSwath, DIA-NN, and dreamDIA...
April 29, 2024: Journal of Proteome Research
#29
JOURNAL ARTICLE
Eliza Lai-Yi Wong, Hong Qiu, Kai-Sing Sun, Phoenix Kit-Han Mo, Angel Hor-Yan Lai, Carrie Ho-Kwan Yam, Ho-Yee Miao, Annie Wai-Ling Cheung, Eng-Kiong Yeoh
OBJECTIVES: To compare the prevalence of anxiety/depression, resilience, and social support among nurses, foreign domestic helpers (FDHs), and residents living in subdivided units (SDUs), and to examine their associations in these high-risk groups in Hong Kong during Omicron waves. METHODS: We recruited 1,014 nurses, 621 FDHs, and 651 SDU residents from December 2021 to May 2022 in this cross-sectional survey. The depression, anxiety, social support, and resilience levels were measured by the validated scales...
2024: International Journal of Public Health
#30
JOURNAL ARTICLE
Stephanie Jensen, Chiung Wu, Camille Simmons, John Green, Ronald Sing, Bradley Thomas, Rafael Torres Fajardo
INTRODUCTION: Identifying patients who can be safely managed in lower-level trauma centers is critical to avoid overburdening level I centers. This study examines the transfer patterns and outcomes of blunt splenic injury (BSI) patients cared for at 2 regional level III trauma centers as compared to an associated level I center. METHODS: A retrospective cohort study was conducted including all trauma patients with BSI admitted to 2 level III trauma centers (TC3) and a level I center (TC1) between 2012 and 2022...
April 28, 2024: American Surgeon
#31
Christy Kwokdinata, Vaibavi Ramanujam, Jiahui Chen, Paula Nunes de Oliveira, Mui Hoon Nai, Wai Hon Chooi, Chwee Teck Lim, Shi Yan Ng, Laurent David, Sing Yian Chew
No abstract text is available yet for this article.
April 28, 2024: ACS Applied Materials & Interfaces
#32
JOURNAL ARTICLE
Qingyu Qin, Wenying Liu, Bing Gao, Xinyan Zhang, Lujia Han, Swee Leong Sing, Xian Liu
The addition of corn starch (CS) enhances the interfacial adhesion of the film-forming liquids (FFLs), weakening the internal relative molecular motion. As a result, the rheological properties and zeta potential values of the FFLs were affected. A tight spatial network structure between capsicum leaf protein (CLP), lignocellulose nanocrystals (LNCs) and CS can be formed through intermolecular entanglement and hydrogen bonding interactions. The crystallinity, thermal degradation temperature, tensile strength and water contact angle of the protein-based bionanocomposite films (PBBFs) increased with increasing CS addition...
April 25, 2024: Food Chemistry
#33
JOURNAL ARTICLE
Oumkaltoum Harati, Sarah Martineau, Alyssia Paquin, Simon Brisebois, Vincent Martel-Sauvageau, Andrée-Anne Leclerc
OBJECTIVES/HYPOTHESIS: Dysphonia is a common voice disorder that can significantly impact a person's life; it requires a collaborative evaluation by both speech-language pathologists and otolaryngologists that takes the patient's perspective into account. The aim of this study was to translate and culturally adapt the Singing Voice Handicap Index questionnaire (SVHI-10), a reliable patient-reported outcome evaluation tool for dysphonia, for the Quebec French population. The result is the Singing Voice Handicap Index-10-QC (SVHI-10-QC)...
April 27, 2024: Journal of Voice
#34
JOURNAL ARTICLE
Li-Hsiou Chen, Yuh-Feng Tsai, Wen-Tzu Wu, Kuo-Liang Chiu, Chia-Wen Tsai, Wen-Shin Chang, Chia-Hsiang Li, Jai-Sing Yang, Mei-Chin Mong, Te-Chun Hsia, DA-Tian Bau
BACKGROUND/AIM: Matrix metalloproteinase-9 (MMP-9) expression is upregulated in various diseases, including lung cancer. However, the role of MMP-9 genotype in lung cancer susceptibility remains uncertain. This study aimed to clarify the contribution of MMP-9 promoter rs3918242 genotypes to the risk of lung cancer in Taiwan. MATERIALS AND METHODS: The MMP-9 rs3918242 genotypes of 358 lung cancer patients and 716 healthy controls were determined using polymerase chain reaction-restriction fragment length polymorphism methodology...
May 2024: Anticancer Research
#35
JOURNAL ARTICLE
Swetha Bindu Velaga, Ahmed Roshdy Alagorie, Mehdi Emamverdi, Maryam Ashrafkhorasani, Abbas Habibi, Muneeswar Gupta Nittala, Gagan Sing, Jonathan Haines, Margaret A Pericak-Vance, Dwight Stambolian, Srinivas R Sadda
PURPOSE: To compare the Ganglion Cell Complex (GCC) thickness in eyes with age-related macular degeneration (AMD) versus healthy controls in an elderly Amish population DESIGN: Cross-sectional study METHODS: This is a post hoc analysis of the family-based prospective study of Amish subjects. Study subjects were imaged by the Cirrus HD-OCT (Carl Zeiss Meditec Inc, Dublin, CA) using a macular cube protocol of 512 × 128 scans (128 horizontal B-scans, each compromising 512 A-scans) over a 6 mm x 6 mm region centered on the fovea...
April 25, 2024: American Journal of Ophthalmology
#36
JOURNAL ARTICLE
Wai-Sing Chan, Christy Wing-Yiu Ho, Tsz-Ching Chan, Jeffrey Hung, Man-Yan To, Sau-Man Leung, Ka-Chun Lai, Ching-Yan Wong, Chin-Pang Leung, Chun-Hang Au, Thomas Shek-Kong Wan, Jonpaul Sze-Tsing Zee, Edmond Shiu-Kwan Ma, Bone Siu-Fai Tang
The BIOFIRE SPOTFIRE Respiratory (R) Panel is a novel, in vitro diagnostic PCR assay with 15 pathogen targets. The runtime is about 15 min which is the shortest among similar panels in the market. We evaluated the performance of the SPOTFIRE R Panel with 151 specimens, including 133 collected from the upper respiratory tract (URT), 13 from the lower respiratory tract (LRT) and 5 external quality assessment program (EQAP) samples. The respiratory specimens were enrolled throughout the first two post-COVID-19 influenza seasons in Hong Kong (March to December 2023)...
April 13, 2024: Viruses
#37
JOURNAL ARTICLE
Mingjie Zhao, Jiahao Yan, Yaotian Wang, Qizhen Chen, Rongjun Cao, Hua Xu, Dong-Sing Wuu, Wan-Yu Wu, Feng-Min Lai, Shui-Yang Lien, Wenzhang Zhu
It is usually difficult to realize high mobility together with a low threshold voltage and good stability for amorphous oxide thin-film transistors (TFTs). In addition, a low fabrication temperature is preferred in terms of enhancing compatibility with the back end of line of the device. In this study, α-IGZO TFTs were prepared by high-power impulse magnetron sputtering (HiPIMS) at room temperature. The channel was prepared under a two-step deposition pressure process to modulate its electrical properties...
April 17, 2024: Nanomaterials
#38
JOURNAL ARTICLE
Zhenye Liu, Cong Li, Wenyu Yang, Qiao Wu, Wenfu Xiao, Yan Zhu, Qiongqiong Wei, Zhanqi Dong, Guizheng Zhang, Cheng Lu, Minhui Pan, Peng Chen
Temperature is an important factor in the growth, development, survival, and reproduction of organisms. The high-temperature resistance mechanism of insects may be significant for use in the prevention and control of insect pests. The silkworm, Bombyx mori , is an important Lepidoptera model species for studies on pest control in agriculture and forestry. We identified a gene in B. mori , the B. mori singed ( Bmsn ) gene, which is involved in the high-temperature resistance of silkworms. Sn proteins are highly conserved among species in many taxonomic groups...
April 12, 2024: Insects
#39
JOURNAL ARTICLE
Hazan Kurtaslan, Ü Ezgi Güleken
This study aims to eliminate the current deficiency in the use of music in the field of special education, to increase musical activities in special education, and to present an accreditation model proposal to increase the skills of institutions, educators, and students. The research was designed with a grounded theory study pattern, one of the qualitative research methods. Data for the research were collected examining the necessary documents, and through semi-structured interviews with experts in both the field of special education and music...
April 15, 2024: Behavioral Sciences
#40
JOURNAL ARTICLE
Fraser Brown, Alice Weidner, Christopher Wells, Rumneet Ghumman, Susan McConnell, Wee Sing Ngu, Elizabeth Ratcliffe, Sharmila Subramaniam, Jamie Barbour
OBJECTIVE: UK endoscopy training is delivered by trainers possessing well developed endoscopy and teaching skills to help learners perform high-quality endoscopy. Train The Trainer (TTT) courses are effective, but additional trainer support is variable with little formal quality assurance. We performed a survey to map UK endoscopy training, assess trainer perspectives on training delivery and identify factors that would enhance training. DESIGN/METHOD: An online survey was designed by trainer representatives, in collaboration with the JAG training committee, and collected responses from trainers registered on JAG endoscopy training system e-portfolio from April to June 2022...
May 2024: Frontline Gastroenterology
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