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https://www.readbyqxmd.com/read/28226667/automatic-seizure-detection-using-correlation-integral-with-nonlinear-adaptive-denoising-and-kalman-filter
#1
Hongda Wang, Chiu-Sing Choy, Hongda Wang, Chiu-Sing Choy, Hongda Wang, Chiu-Sing Choy
The ability of correlation integral for automatic seizure detection using scalp EEG data has been re-examined in this paper. To facilitate the detection performance and overcome the shortcoming of correlation integral, nonlinear adaptive denoising and Kalman filter have been adopted for pre-processing and post-processing. The three-stage algorithm has achieved 84.6% sensitivity and 0.087/h false detection rate, which are comparable to many machine learning based methods, but at much lower computational cost...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226309/the-feasibility-of-singing-to-improve-gait-in-parkinson-disease
#2
Elinor C Harrison, Marie E McNeely, Gammon M Earhart
Brain regions important for controlling movement are also responsible for rhythmic processing. In Parkinson disease (PD), defective internal timing within the brain has been linked to impaired beat discrimination, and may contribute to a loss of ability to maintain a steady gait rhythm. Less rhythmic gait is inherently less efficient, and this may lead to gait impairment including reduced speed, cadence, and stride length, as well as increased variability. While external rhythmic auditory stimulation (e.g. a metronome beat) is well-established as an effective tool to stabilize gait in PD, little is known about whether self-generated cues such as singing have the same beneficial effect on gait in PD...
February 14, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28223137/human-clec16a-regulates-autophagy-through-modulating-mtor-activity
#3
Rachel Chun Yee Tam, Michelle Wing Man Li, Yan Pan Gao, Yuen Ting Pang, Sheng Yan, Wei Ge, Chak Sing Lau, Vera Sau Fong Chan
CLEC16A is genetically linked with multiple autoimmune disorders but its functional relevance in autoimmunity remains obscure. Recent evidence has signposted the emerging role of autophagy in autoimmune disease development. Here, by ectopic expression and siRNA silencing, we show that CLEC16A has an inhibitory role in starvation-induced autophagy in human cells. Combining quantitative proteomics and immunoblotting analyses, we found that CLEC16A likely regulates autophagy by activating mTOR pathway. Overexpression of CLEC16A was found to sensitize cells towards the availability of nutrients, resulting in a heightened mTOR activity, which in turn diminished LC3 autophagic activity following nutrient deprivation...
February 18, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28222852/passing-on-pediatric-donors-hearts-picky-or-prudent
#4
EDITORIAL
Ming-Sing Si
No abstract text is available yet for this article.
February 2, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28216192/does-expert-opinion-match-the-operational-definition-of-the-lupus-low-disease-activity-state-lldas-a-case-based-construct-validity-study
#5
Vera Golder, Molla Huq, Kate Franklyn, Alicia Calderone, Aisha Lateef, Chak Sing Lau, Alfred Lok Hang Lee, Sandra Teresa V Navarra, Timothy Godfrey, Shereen Oon, Alberta Yik Bun Hoi, Eric Francis Morand, Mandana Nikpour
OBJECTIVE: To evaluate the construct validity of the Lupus Low Disease Activity State (LLDAS), a treatment target in systemic lupus erythematosus (SLE). METHODS: Fifty SLE case summaries based on real patients were prepared and assessed independently for meeting the operational definition of LLDAS. Fifty international rheumatologists with expertise in SLE, but with no prior involvement in the LLDAS project, responded to a survey in which they were asked to categorize the disease activity state of each case as remission, low, moderate, or high...
January 18, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28216159/dynamic-cyclic-compression-modulates-the-chondrogenic-phenotype-in-human-chondrocytes-from-late-stage-osteoarthritis
#6
Hua Jia Diao, Hon Sing Fung, Pan Yeung, K L Lam, Chun Hoi Yan, Barbara Pui Chan
Human osteoarthritic chondrocytes (hOACs) are characterized by their "dedifferentiated" and catabolic phenotype and lack the ability for restoring their inherent functions by themselves. Here we investigated whether extrinsically supplemented mechanical signal via compression loading would affect the phenotype of hOACs. Specifically, we applied cyclic compression loading on cultured hOACs-collagen constructs and measured the expression of the major chondrogenic factors, cell-matrix interaction molecules and matrix degradation enzymes...
February 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28215557/long-term-two-photon-imaging-in-awake-macaque-monkey
#7
Ming Li, Fang Liu, Hongfei Jiang, Tai Sing Lee, Shiming Tang
Successful application of two-photon imaging with genetic tools in awake macaque monkeys will enable fundamental advances in our understanding of higher cognitive function at the level of molecular and neuronal circuits. Here we report techniques for long-term two-photon imaging in awake macaque monkeys. Using genetically encoded indicators including GCaMP5 and GCaMP6s delivered by AAV2/1 into the visual cortex, we demonstrate that high-quality two-photon imaging of large neuronal populations can be achieved and maintained in awake monkeys for months...
February 8, 2017: Neuron
https://www.readbyqxmd.com/read/28214373/improved-detection-of-zika-virus-rna-in-human-and-animal-specimens-by-a-novel-highly-sensitive-and-specific-real-time-rt-pcr-assay-targeting-the-5-untranslated-region-of-zika-virus
#8
Jasper Fuk-Woo Chan, Cyril Chik-Yan Yip, Kah-Meng Tee, Zheng Zhu, Jessica Oi-Ling Tsang, Kenn Ka-Heng Chik, Terance Gi-Wai Tsang, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Siddharth Sridhar, Feifei Yin, Ivan Fan-Ngai Hung, Sandy Ka-Yee Chau, Anna Jinxia Zhang, Kwok-Hung Chan, Kwok-Yung Yuen
OBJECTIVE AND METHOD: We developed and evaluated five novel real-time RT-PCR assays targeting conserved regions in the 5'-untranslated region (5'-UTR), envelope (E'), non-structural protein 2A (NS2A), NS5, and 3'-UTR of the ZIKV genome. RESULTS: The ZIKV-5'-UTR assay exhibited the lowest in-vitro limit of detection (5-10 RNA copies/reaction and 3.0×10(-1) plaque-forming units/ml). Compared to the modified version of a widely adopted RT-PCR assay targeting the ZIKV-E gene, the ZIKV-5'-UTR assay showed better sensitivity in human clinical specimens, and representative mouse specimens, including many organs which are known to be involved in human ZIKV infection but difficult to obtain in clinical settings...
February 18, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28214051/effects-of-a-straw-phonation-protocol-on-acoustic-measures-of-an-satb-chorus-singing-two-contrasting-renaissance-works
#9
Jeremy N Manternach, Chad Clark, James F Daugherty
BACKGROUND: Researchers have found that semi-occluded vocal tract (SOVT) exercises may increase vocal economy by reducing phonation threshold pressure and effort while increasing or maintaining consistent acoustic output. This research has focused solely on individual singers. Much singing instruction, however, takes place in choral settings. Choral singers may use different resonance strategies or unconsciously adjust their singing based on the ability to hear their own sound in relation to others...
February 14, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28211972/tsc2-c-1864c-t-variant-associated-with-mild-cases-of-tuberous-sclerosis-complex
#10
Laura S Farach, William T Gibson, Steven P Sparagana, Mark Nellist, Connie T R M Stumpel, Marja Hietala, Elliott Friedman, Deborah A Pearson, Susan P Creighton, Annemiek Wagemans, Reveel Segel, Efrat Ben-Shalom, Kit Sing Au, Hope Northrup
Tuberous sclerosis complex (TSC) is an autosomal dominantly inherited disorder with variable expressivity associated with hamartomatous tumors, abnormalities of the skin, and neurologic problems including seizures, intellectual disability, and autism. TSC is caused by pathogenic variants in either TSC1 or TSC2. In general, TSC2 pathogenic variants are associated with a more severe phenotype than TSC1 pathogenic variants. Here, we report a pathogenic TSC2 variant, c.1864C>T, p.(Arg622Trp), associated with a mild phenotype, with most carriers meeting fewer than two major clinical diagnostic criteria for TSC...
March 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28202581/identification-and-functional-implications-of-sodium-myo-inositol-cotransporter-1-in-pancreatic-beta-cells-and-type-2-diabetes-mellitus
#11
Stephen Yu Ting Li, Sam Tsz Wai Cheng, Dan Zhang, Po Sing Leung
Myo-inositol (MI), the precursor of the second messenger phosphoinositide (PI), mediates multiple cellular events. Rat islets exhibit active transport of MI, though the mechanism involved remains elusive. Here, we report, for the first time, the expression of sodium/myo-inositol cotransporter 1 (SMIT1) in rat islets and specifically, β-cells. Genetic or pharmacological inhibition of SMIT impaired glucose-stimulated insulin secretion by INS-1E cells, probably via down-regulation of PI signaling. Additionally, we found that SMIT1 expression in INS-1E cells and isolated islets was augmented by acute high-glucose exposure and reduced in chronic hyperglycemia conditions...
February 15, 2017: Diabetes
https://www.readbyqxmd.com/read/28198806/arrays-of-individual-dna-molecules-on-nanopatterned-substrates
#12
Roland Hager, Alma Halilovic, Jonathan R Burns, Friedrich Schäffler, Stefan Howorka
Arrays of individual molecules can combine the advantages of microarrays and single-molecule studies. They miniaturize assays to reduce sample and reagent consumption and increase throughput, and additionally uncover static and dynamic heterogeneity usually masked in molecular ensembles. However, realizing single-DNA arrays must tackle the challenge of capturing structurally highly dynamic strands onto defined substrate positions. Here, we create single-molecule arrays by electrostatically adhering single-stranded DNA of gene-like length onto positively charged carbon nanoislands...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197628/resveratrol-induced-autophagy-and-apoptosis-in-cisplatin-resistant-human-oral-cancer-car-cells-a-key-role-of-ampk-and-akt-mtor-signaling
#13
Chao-Hsiang Chang, Chao-Ying Lee, Chi-Cheng Lu, Fuu-Jen Tsai, Yuan-Man Hsu, Je-Wei Tsao, Yu-Ning Juan, Hong-Yi Chiu, Jai-Sing Yang, Ching-Chiung Wang
Resveratrol is known to be an effective chemo-preventive phytochemical against multiple tumor cells. However, the increasing drug resistance avoids the cancer treatment in oral cavity cancer. In this study, we investigated the oral antitumor activity of resveratrol and its mechanism in cisplatin-resistant human oral cancer CAR cells. Our results demonstrated that resveratrol had an extremely low toxicity in normal oral cells and provoked autophagic cell death to form acidic vesicular organelles (AVOs) and autophagic vacuoles in CAR cells by acridine orange (AO) and monodansylcadaverine (MDC) staining...
March 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28195525/observing-others-speak-or-sing-activates-spt-and-neighboring-parietal-cortex
#14
Daniele Corbo, Guy A Orban
To obtain further evidence that action observation can serve as a proxy for action execution and planning in posterior parietal cortex, we scanned participants while they were (1) observing two classes of action: vocal communication and oral manipulation, which share the same effector but differ in nature, and (2) rehearsing and listening to nonsense sentences to localize area Spt, thought to be involved in audio-motor transformation during speech. Using this localizer, we found that Spt is specifically activated by vocal communication, indicating that Spt is not only involved in planning speech but also in observing vocal communication actions...
February 14, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28194232/post-challenge-insulin-concentration-is-useful-for-differentiating-between-coronary-artery-disease-and-cardiac-syndrome-x-in-subjects-without-known-diabetes-mellitus
#15
Kae-Woei Liang, Wayne H-H Sheu, Wen-Jane Lee, Wen-Lieng Lee, Hung-Chih Pan, I-Te Lee, Jun-Sing Wang
BACKGROUND: Cardiac syndrome X (CSX) is characterized by angina pectoris but with patent coronary arteries. Our previous study demonstrated that subjects with CSX had a higher fasting insulin-resistance (IR) than the controls. However, few studies have investigated the degree of IR, including oral glucose tolerance test (OGTT)-derived indices and profiles of metabolic abnormalities between CSX and coronary artery disease (CAD). METHODS: Ninety-two CSX and 145 CAD subjects without known diabetes mellitus (DM) underwent coronary angiogram (CAG) for angina pectoris and also agreed to receive OGTT and glycated hemoglobin (HbA1C) evaluations for screening abnormal glucose regulation and IR...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28192818/-benefits-of-measures-to-promote-development-in-language-mathematics-and-singing-in-kindergardeners-analysis-of-data-collected-at-school-entrance-examination-in-the-county-of-biberach
#16
Ulrike Hart, Manfred Wildner, Daniela Krämer, Alexander Crispin
To evaluate the benefits of implementing measures to promote skills in the areas of language, mathematics and singing in kindergardeners by statistical analysis of data collected during the school entrance examination (ESU) of 4-5-year-old children from the county of Biberach. Study 1 employs multivariate regression analysis to analyse - in chronological order - the ESU data on 4 cohorts (2011-2014; n=7 148) of children of the Biberach county. Study 2 qualitatively compares identical data representative of the entire state of Baden-Württemberg (N=3×80 000) with the Biberach results...
February 13, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28190669/insurance-status-affects-postoperative-morbidity-and-complication-rate-after-shoulder-arthroplasty
#17
Xinning Li, David R Veltre, Antonio Cusano, Paul Yi, David Sing, Joel J Gagnier, Josef K Eichinger, Andrew Jawa, Asheesh Bedi
BACKGROUND: Shoulder arthroplasty is an effective procedure for managing patients with shoulder pain secondary to end-stage arthritis. Insurance status has been shown to be a predictor of patient morbidity and mortality. The current study evaluated the effect of patient insurance status on perioperative outcomes after shoulder replacement surgery. METHODS: Data between 2004 and 2011 were obtained from the Nationwide Inpatient Sample. Analysis included patients undergoing shoulder arthroplasty (partial, total, and reverse) procedures determined by International Classification of Disease, 9th Revision procedure codes...
February 10, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28190491/influence-of-milking-method-disinfection-and-herd-management-practices-on-bulk-tank-milk-somatic-cell-counts-in-tropical-dairy-herds-in-colombia
#18
J Reyes, J Sanchez, H Stryhn, T Ortiz, M Olivera, G P Keefe
The aims of this study were to evaluate the effects of milking method, disinfection practices and other management factors on the bulk tank milk somatic cell count (BTSCC) in tropical dairy herds and to examine potential interactions with time. One hundred and thirty farms in the Northern region of Antioquia, Colombia, were visited once per month for 24 months. A two level linear mixed model for repeated measures was used to assess the impact on log transformed BTSCC (lnBTSCC). The geometric mean of the BTSCC for all herds was 262,330 cells/mL...
February 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28187923/the-impact-of-a-teaching-or-singing-career-on-the-female-vocal-quality-at-the-mean-age-of-67-years-a-pilot-study
#19
Evelien D'haeseleer, Sofie Claeys, Kim Bettens, Laura Leemans, Ann-Sophie Van Calster, Nina Van Damme, Zoë Thijs, Julie Daelman, Clara Leyns, Kristiane Van Lierde
OBJECTIVES: The purpose of this study was to measure the objective and subjective vocal quality in women aged between 60 and 75 years. Secondly, the impact of a teaching or singing career on the vocal quality was investigated by comparing the vocal quality of retired women with different careers. STUDY DESIGN: This is a case-control study. METHODS: Seventy-three retired women between 60 and 75 years (mean age: 67 years, standard deviation: 4...
February 7, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28186910/robustness-analysis-on-dual-neural-network-based-kwta-with-input-noise
#20
Ruibin Feng, Chi-Sing Leung, John Sum
This paper studies the effects of uniform input noise and Gaussian input noise on the dual neural network-based kWTA (DNN-kWTA) model. We show that the state of the network (under either uniform input noise or Gaussian input noise) converges to one of the equilibrium points. We then derive a formula to check if the network produce correct outputs or not. Furthermore, for the uniformly distributed inputs, two lower bounds (one for each type of input noise) on the probability that the network produces the correct outputs are presented...
February 6, 2017: IEEE Transactions on Neural Networks and Learning Systems
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