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https://www.readbyqxmd.com/read/28099262/angiotensin-ii-type-2-receptor-activation-with-compound-21-augments-islet-function-and-regeneration-in-streptozotocin-induced-neonatal-rats-and-human-pancreatic-progenitor-cells
#1
Lin Wang, Yi Wang, Xing Yu Li, Po Sing Leung
OBJECTIVES: We investigated the effects of compound 21 (C21), a nonpeptide angiotensin II type 2 receptor agonist, on islet cell function and survival in streptozotocin (STZ)-treated neonatal rats and human pancreatic progenitor cells. METHODS: Neonatal rats were randomized into 5 groups, including a control, an STZ (100 mg/kg, intraperitoneally), and 3 STZ + C21 (0.25, 0.5, and 1 mg/kg per day for 7 days, intraperitoneally) groups. Body weight and blood glucose were monitored daily...
January 18, 2017: Pancreas
https://www.readbyqxmd.com/read/28098885/carboxamide-analog-itr-284-evokes-apoptosis-and-inhibits-migration-ability-in-human-lung-adenocarcinoma-a549-cells
#2
Jai-Sing Yang, Chia-An Lin, Chi-Cheng Lu, Yen-Fang Wen, Fuu-Jen Tsai, Shih-Chang Tsai
Lung adenocarcinoma is the most common type of lung cancer and found in both smokers and non-smokers, but the treatment of lung cancer is limited. ITR-284 has been shown to be a potent carboxamide-derived anticancer agent and to induce apoptosis in leukemia and colon cancer cells. However, little is known whether ITR-284 has anticancer activity in human lung adenocarcinoma cells through induction of apoptosis and suppression of migration in vitro. We showed that ITR-284 inhibited human lung cancer A549 cells using the thiazolyl blue tetrazolium bromide (MTT) assay and evoked apoptosis via the cell cycle distribution at S phase arrest...
January 16, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28098522/mcgurk-effect-in-gender-identification-vision-trumps-audition-in-voice-judgments
#3
Zehra F Peynircioǧlu, William Brent, Joshua R Tatz, Jordan Wyatt
Demonstrations of non-speech McGurk effects are rare, mostly limited to emotion identification, and sometimes not considered true analogues. We presented videos of males and females singing a single syllable on the same pitch and asked participants to indicate the true range of the voice-soprano, alto, tenor, or bass. For one group of participants, the gender shown on the video matched the gender of the voice heard, and for the other group they were mismatched. Soprano or alto responses were interpreted as "female voice" decisions and tenor or bass responses as "male voice" decisions...
January 2017: Journal of General Psychology
https://www.readbyqxmd.com/read/28097295/association-of-systemic-medication-use-with-intraocular-pressure-in-a-multiethnic-asian-population-the-singapore-epidemiology-of-eye-diseases-study
#4
Henrietta Ho, Yuan Shi, Jacqueline Chua, Yih-Chung Tham, Sing Hui Lim, Tin Aung, Tien Yin Wong, Ching-Yu Cheng
Importance: There is limited understanding of the associations between systemic medication use and intraocular pressure (IOP) in the general population. Objective: To examine the association between systemic medication use and IOP in a multiethnic Asian population. Design, Setting, and Participants: In this post hoc analysis of the Singapore Epidemiology of Eye Diseases study, a population-based study of 10 033 participants (78.7% response rate) from 3 racial/ethnic groups (Chinese [recruited from February 9, 2009, through December 19, 2011], Malays [recruited from August 16, 2004, though July 10, 2006], and Indians [recruited from May 21, 2007, through December 29, 2009]), participants with glaucoma, previous ocular surgery, or trauma and an IOP asymmetry greater than 5 mm Hg between eyes were excluded...
January 12, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28096866/disseminated-strongyloidiasis-in-an-iranian-immunocompromised-patient-a-case-report
#5
Narges Najafi, Eissa Soleymani, Shahabeddin Sarvi, Amirkeivan Marofi, Anahita Nosrati, Alireza Davoodi
Strongyloides stercoralis is a soil-transmitted helminth (STH) widespread in various part of the world. A 78-yr-old peasant diabetic female from Mazandaran Province northern Iran, was admitted to Infection Department of the Razi Hospital in city of Qaemshahr, north of Iran complaining about abdominal skin rash, pruritus, itching, anorexia, nausea, vomiting, dysuria and cough. This patient had cutaneous migration effects of S. stercoralis larvae in her abdominal skin (larva currents and urticaria). Lung CT without contrast demonstrate s bilateral diffuse ground glass opacity draws attention...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28096429/lombard-effect-onset-times-reveal-the-speed-of-vocal-plasticity-in-a-songbird
#6
Samuel I Hardman, Sue Anne Zollinger, Klemen Koselj, Stefan Leitner, Rupert C Marshall, Henrik Brumm
Animals that use vocal signals to communicate often compensate for interference and masking from background noise by raising the amplitude of their vocalisations. This response has been termed the Lombard effect. However, despite more than a century of research little is known how quickly animals can adjust the amplitude of their vocalisations after the onset of noise. The ability to respond quickly to increases in noise levels would allow animals to avoid signal masking and ensure their calls continue to be heard, even if they are interrupted by sudden bursts of high amplitude noise...
January 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28088051/online-recruitment-and-testing-of-infants-with-mechanical-turk
#7
Michelle Tran, Laura Cabral, Ronak Patel, Rhodri Cusack
Testing infants in the laboratory is expensive in time and money; consequently, many studies are underpowered, reducing their reproducibility. We investigated whether the online platform, Amazon Mechanical Turk (MTurk), could be used as a resource to more easily recruit and measure the behavior of infant populations. Using a looking time paradigm, with users' webcams we recorded how long infants aged 5 to 8months attended while viewing children's television programs. We found that infants (N=57) were more reliably engaged by some movies than by others and that the most engaging movies could maintain attention for approximately 70% of a 10- to 13-min period...
January 11, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28087005/and-the-fat-lady-sings-about-phosphate-and-calcium
#8
Carsten A Wagner, Pedro H Imenez Silva, Isabel Rubio-Aliaga
Adipose tissue has been long recognized as secreting various endocrine factors. Emerging evidence demonstrates that adipokines play a role in modulating systemic mineral homeostasis through endocrine loops involving interleukin-6, leptin, and now also adiponectin, which all interact with FGF23 and vitamin D and thereby change the renal control of calcium and phosphate metabolism. Understanding these regulatory loops may shed light on a complex interorgan crosstalk controlling mineral homeostasis and its dysregulation in diseases associated with obesity...
February 2017: Kidney International
https://www.readbyqxmd.com/read/28077607/anatomy-of-mdm2-and-mdm4-in-evolution
#9
REVIEW
Ban Xiong Tan, Hoe Peng Liew, Joy S Chua, Farid J Ghadessy, Yaw Sing Tan, David P Lane, Cynthia R Coffill
Mouse double minute (Mdm) genes span an evolutionary timeframe from the ancient eukaryotic placozoa Trichoplax adhaerens to Homo sapiens, implying a significant and possibly conserved cellular role throughout history. Maintenance of DNA integrity and response to DNA damage involve many key regulatory pathways, including precise control over the tumour suppressor protein p53. In most vertebrates, degradation of p53 through proteasomal targeting is primarily mediated by heterodimers of Mdm2 and the Mdm2-related protein Mdm4 (also known as MdmX)...
January 10, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28073557/diatom-nitzschia-navis-varingica-bacillariophyceae-and-its-domoic-acid-production-from-the-mangrove-environments-of-malaysia
#10
Suh Nih Tan, Sing Tung Teng, Hong Chang Lim, Yuichi Kotaki, Stephen S Bates, Chui Pin Leaw, Po Teen Lim
The distribution of the toxic pennate diatom Nitzschia was investigated at four mangrove areas along the coastal brackish waters of Peninsular Malaysia. Eighty-two strains of N. navis-varingica were isolated and established, and their identity confirmed morphologically and molecularly. Frustule morphological characteristics of the strains examined are identical to previously identified N. navis-varingica, but with a sightly higher density of the number of areolae per 1μm (4-7 areolae). Both LSU and ITS rDNAs phylogenetic trees clustered all strains in the N...
December 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073527/new-scenario-for-speciation-in-the-benthic-dinoflagellate-genus-coolia-dinophyceae
#11
Chui Pin Leaw, Toh Hii Tan, Hong Chang Lim, Sing Tung Teng, Hwa Lin Yong, Kirsty F Smith, Lesley Rhodes, Matthias Wolf, William C Holland, Mark W Vandersea, R Wayne Litaker, Patricia A Tester, Haifeng Gu, Gires Usup, Po Teen Lim
In this study, inter- and intraspecific genetic diversity within the marine harmful dinoflagellate genus Coolia Meunier was evaluated using isolates obtained from the tropics to subtropics in both Pacific and Atlantic Ocean basins. The aim was to assess the phylogeographic history of the genus and to clarify the validity of established species including Coolia malayensis. Phylogenetic analysis of the D1-D2 LSU rDNA sequences identified six major lineages (L1-L6) corresponding to the morphospecies Coolia malayensis (L1), C...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28067399/conversion-of-1t-mose2-to-2h-mos2xse2-2x-mesoporous-nanospheres-for-superior-sodium-storage-performance
#12
Junjun Zhang, Wenpei Kang, Miao Jiang, Yu You, Yulin Cao, Tsz-Wai Ng, Denis Y W Yu, Chun-Sing Lee, Jun Xu
S-Doped 2H-MoSe2 (i.e., 2H-MoS2xSe2-2x) mesoporous nanospheres assembled from several-layered nanosheets are synthesized by sulfurizing freshly-prepared 1T-MoSe2 nanospheres, and they serve as a robust host material for sodium storage. The sulfuration treatment is found to be beneficial for removing surface/interface insulating organic contaminants and converting the 1T phase to the 2H phase with improved crystallinity and electrical conductivity. These result in significantly enhanced sodium storage performance, including charge/discharge capacity, first Coulombic efficiency, cycling stability, and rate capability...
January 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28067076/vocal-training-in-an-anthropometrical-aspect
#13
Marzena Wyganowska-Świątkowska, Iwona Kowalkowska, Grażyna Flicińska-Pamfil, Mikołaj Dąbrowski, Przemysław Kopczyński, Bożena Wiskirska-Woźnica
OBJECTIVES: As shown in our previous paper, the dimensions of the cerebral parts of the cranium and face of the vocal students were higher than those of the non-singing students. The aim of the present study was to analyse the type of voice and its development depending on selected dimensions. METHODS: A total of 56 vocal students - 36 women and 20 men - who underwent anthropometric measurements were divided into groups according to their voice type. Two professors of singing made a subjective, independent evaluation of individual students' vocal development progress during the four years of training...
January 9, 2017: Logopedics, Phoniatrics, Vocology
https://www.readbyqxmd.com/read/28065846/the-association-of-heart-failure-related-micrornas-with-neurohormonal-signaling
#14
Yei-Tsung Chen, Juan Wang, Kai Sing Tong, Lee Lee Wong, Oi Wah Liew, Arthur Mark Richards
Heart failure (HF) is a widely prevalent syndrome imposing a significant burden of morbidity and mortality world-wide. Differential circulating microRNA profiles observed in HF cohorts suggest the diagnostic utility of microRNAs as biomarkers. Given their function in fine tuning gene expression, alternations in microRNA landscape could reflecting the underlying mechanisms of disease and present potential therapeutic targets. Using multiple computational target predicting algorithms together with the luciferase-based reporting platform, the interactions between HF-related microRNAs and the 3' untranslated regions (3'UTRs) of neurohormone associated genes were examined and compared...
January 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28063367/effects-of-high-fructose-intake-on-the-development-of-hypertension-in-the-spontaneously-hypertensive-rats-the-role-of-at1r-gp91-phox-signaling-in-the-rostral-ventrolateral-medulla
#15
Kay L H Wu, Chih-Wei Wu, You-Lin Tain, Yung-Mei Chao, Chun-Ying Hung, Pei-Chia Tsai, Wei-Sing Wang, Cheng-Dean Shih
Both genetic and dietary factors determine the development of hypertension. Whether dietary factor impacts the development of hereditary hypertension is unknown. Here, we evaluated the effect of daily high-fructose diet (HFD) on the development of hypertension in adolescent spontaneously hypertensive rats (SHR). Six-week-old SHR were randomly divided into two groups to receive HFD or normal diet (ND) for 3 weeks. The temporal profile of systolic blood pressure, alongside the sympathetic vasomotor activity, in the SHR-HFD showed significantly greater increases at 9-12 weeks of age compared with the age-matched SHR-ND group...
December 5, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28059867/influence-of-the-kdm4a-rs586339-polymorphism-on-overall-survival-in-asian-non-small-cell-lung-cancer-patients
#16
Charlie Marvalim, Jing Xiang Gimson Wong, Natalia Sutiman, Wan Teck Lim, Shao Weng Tan, Ravindran Kanesvaran, Quan Sing Ng, Amit Jain, Mei Kim Ang, Wan Ling Tan, Chee Keong Toh, Eng Huat Tan, Balram Chowbay
The critical role of lysine demethylase 4A (KDM4A), in regulating chromatin structure and consequently in driving cellular proliferation and oncogenesis has been the focus of recent studies. Non-small-cell lung cancer (NSCLC) patients with adenocarcinoma histology who were homozygous for KDM4A single nucleotide polymorphism (SNP)-A482 (rs586339) were recently shown to have significantly worse overall survival (OS) compared with patients with the wild-type or the heterozygous genotype at this locus (hazard ratio=1...
January 2, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28057332/influence-of-geometry-and-material-of-insulating-posts-on-particle-trapping-using-positive-dielectrophoresis
#17
Georg R Pesch, Fei Du, Michael Baune, Jorg Thöming
Insulator-based dielectrophoresis (iDEP) is a powerful particle analysis technique based on electric field scattering at material boundaries which can be used, for example, for particle filtration or to achieve chromatographic separation. Typical devices consist of microchannels containing an array of posts but large scale application was also successfully tested. Distribution and magnitude of the generated field gradients and thus the possibility to trap particles depends apart from the applied field strength on the material combination between post and surrounding medium and on the boundary shape...
December 26, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28055082/association-of-dsm-iv-posttraumatic-stress-disorder-with-traumatic-experience-type-and-history-in-the-world-health-organization-world-mental-health-surveys
#18
Howard Liu, Maria V Petukhova, Nancy A Sampson, Sergio Aguilar-Gaxiola, Jordi Alonso, Laura Helena Andrade, Evelyn J Bromet, Giovanni de Girolamo, Josep Maria Haro, Hristo Hinkov, Norito Kawakami, Karestan C Koenen, Viviane Kovess-Masfety, Sing Lee, Maria Elena Medina-Mora, Fernando Navarro-Mateu, Siobhan O'Neill, Marina Piazza, José Posada-Villa, Kate M Scott, Victoria Shahly, Dan J Stein, Margreet Ten Have, Yolanda Torres, Oye Gureje, Alan M Zaslavsky, Ronald C Kessler
Importance: Previous research has documented significant variation in the prevalence of posttraumatic stress disorder (PTSD) depending on the type of traumatic experience (TE) and history of TE exposure, but the relatively small sample sizes in these studies resulted in a number of unresolved basic questions. Objective: To examine disaggregated associations of type of TE history with PTSD in a large cross-national community epidemiologic data set. Design, Setting, and Participants: The World Health Organization World Mental Health surveys assessed 29 TE types (lifetime exposure, age at first exposure) with DSM-IV PTSD that was associated with 1 randomly selected TE exposure (the random TE) for each respondent...
January 4, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28051132/determining-the-migration-duration-of-rice-leaf-folder-cnaphalocrocis-medinalis-guen%C3%A3-e-moths-using-a-trajectory-analytical-approach
#19
Feng-Ying Wang, Fan Yang, Ming-Hong Lu, Shan-Yu Luo, Bao-Ping Zhai, Ka-Sing Lim, Caitríona E McInerney, Gao Hu
Many moths finish their long distance migration after consecutive nights, but little is known about migration duration and distance. This information is key to predicting migration pathways and understanding their evolution. Tethered flight experiments have shown that ovarian development of rice leaf folder (Cnaphalocrocis medinalis [Guenée]) moths was accelerated and synchronized by flight in the first three nights, whereby most females were then matured for mating and reproduction. Thus, it was supposed that this moth might fly three nights to complete its migration...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28046857/mo-de-207b-08-radiomic-ct-features-complement-semantic-annotations-to-predict-egfr-mutations-in-lung-adenocarcinomas
#20
E Rios Velazquez, Y Liu, C Parmar, V Narayan, R Gillies, H Aerts
PURPOSE: To compare the complementary value of quantitative radiomic features to that of radiologist-annotated semantic features in predicting EGFR mutations in lung adenocarcinomas. METHODS: Pre-operative CT images of 258 lung adenocarcinoma patients were available. Tumors were segmented using the sing-click ensemble segmentation algorithm. A set of radiomic features was extracted using 3D-Slicer. Test-retest reproducibility and unsupervised dimensionality reduction were applied to select a subset of reproducible and independent radiomic features...
June 2016: Medical Physics
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