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Systemic inflammatory response syndrome

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https://www.readbyqxmd.com/read/29784123/endovascular-interventions-for-venous-disease
#1
REVIEW
Paul O'Connor, Robert Lookstein
Venous thromboembolism, including deep vein thrombosis and pulmonary embolism, occur in up to 900,000 people per year in the United States. Current first-line therapy consists of systemic anticoagulation with a goal to prevent additional thrombus formation. Treatment with anticoagulation alone provides less than satisfactory results with some studies showing propagation of thrombus in almost 40% of cases. Current first-line therapy does not include active removal of thrombus and does little to alleviate acute symptoms and the damaging inflammatory response that may result in postthrombotic syndrome...
June 2018: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/29780830/the-cd40-rs1883832-polymorphism-affects-sepsis-susceptibility-and-scd40l-levels
#2
Zuo-Liang Liu, Jing Hu, Xue-Fei Xiao, Yue Peng, Shang-Ping Zhao, Xian-Zhong Xiao, Ming-Shi Yang
Sepsis is a severe and progressive disease characterized by systemic inflammatory response syndrome (SIRS). CD40 serves as a vital link between immune response and inflammation. This study was designed to investigate the potential association between a functional single-nucleotide polymorphism (SNP) of CD40 (rs1883832) and susceptibility to sepsis. We first performed a case-control study to explore the relationship between the CD40 rs1883832 polymorphism and sepsis. CD40 mRNA expression and protein expression were determined by real-time PCR and western blotting, respectively, in peripheral blood mononuclear cells (PBMCs) from sepsis patients and healthy controls...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29780224/correlative-study-between-c-reactive-protein-clinical-severity-and-nerve-conduction-studies-in-guillain-barr%C3%A3-syndrome
#3
Yosria A Altaweel, Sawsan Abdelaziz, Hala A Fathy, Shimaa AbdelBadea
Background: Guillain-Barre' syndrome (GBS) is a serious autoimmune disorder in which the immune system attacks healthy nerve cells of the peripheral nervous system causing polyradiculoneuropathy which leads to weakness, numbness, and tingling, and can eventually cause paralysis. Autoimmune conditions like GBS can induce a high level of inflammation resulting in an increase in the C-reactive protein( CRP) production. The aim of this study is to assess the relationship between CRP level and the clinical severity as well as the electrophysiological findings of nerve conduction studies in patients with GBS...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
https://www.readbyqxmd.com/read/29779831/interleukin-6-significantly-improves-predictive-value-of-systemic-inflammatory-response-syndrome-for-predicting-severe-acute-pancreatitis
#4
Saransh Jain, Shallu Midha, Soumya Jagannath Mahapatra, Swatantra Gupta, Manish Kumar Sharma, Baibaswata Nayak, Tony George Jacob, Shalimar, Pramod Kumar Garg
BACKGROUND: Predicting severe acute pancreatitis (AP) is important for triage, prognosis, and designing therapeutic trials. Persistent systemic inflammatory response syndrome (SIRS) predicts severe AP but its diagnostic accuracy is suboptimal. Our objective was to study if cytokine levels could improve the predictive value of clinical variables for the development of severe AP. METHODS: Consecutive patients with AP were included in a prospective cohort study at a tertiary care center...
May 14, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29778659/sepsis-3-septic-shock-criteria-and-associated-mortality-among-infected-hospitalized-patients-assessed-by-a-rapid-response-team
#5
Shannon M Fernando, Peter M Reardon, Bram Rochwerg, Nathan I Shapiro, Donald M Yealy, Andrew J E Seely, Jeffrey J Perry, Douglas P Barnaby, Kyle Murphy, Peter Tanuseputro, Kwadwo Kyeremanteng
BACKGROUND: Rapid Response Teams (RRTs) respond to deteriorating hospitalized patients, and help determine subsequent management, including Intensive Care Unit (ICU) admission. In such patients with sepsis and septic shock, the Sepsis-3 clinical criteria have a potential role in detection, risk-stratification, and prognostication, though their accuracy in comparison to the Systemic Inflammatory Response Syndrome (SIRS)-based septic shock criteria are unknown. We sought to evaluate prognostic accuracy of the Sepsis-3 criteria for in-hospital mortality among infected hospitalized patients with acute deterioration...
May 17, 2018: Chest
https://www.readbyqxmd.com/read/29770795/cytokines-as-biomarkers-of-inflammatory-response-after-open-versus-endovascular-repair-of-abdominal-aortic-aneurysms-a-systematic-review
#6
REVIEW
Diamantis I Tsilimigras, Fragiska Sigala, Georgios Karaolanis, Ioannis Ntanasis-Stathopoulos, Eleftherios Spartalis, Michael Spartalis, Nikolaos Patelis, Alexandros Papalampros, Chandler Long, Demetrios Moris
The repair of an abdominal aortic aneurysm (AAA) is a high-risk surgical procedure related to hormonal and metabolic stress-related response with an ensuing activation of the inflammatory cascade. In contrast to open repair (OR), endovascular aortic aneurysm repair (EVAR) seems to decrease the postoperative stress by offering less extensive incisions, dissection, and tissue manipulation. However, these beneficial effects may be offset by the release of cytokines and arachidonic acid metabolites during intra-luminal manipulation of the thrombus using catheters in endovascular repair, resulting in systemic inflammatory response (SIR), which is clinically called post-implantation syndrome...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29770247/using-statistical-and-machine-learning-methods-to-evaluate-the-prognostic-accuracy-of-sirs-and-qsofa
#7
Akash Gupta, Tieming Liu, Scott Shepherd, William Paiva
Objectives: The objective of this study was to compare the performance of two popularly used early sepsis diagnostic criteria, systemic inflammatory response syndrome (SIRS) and quick Sepsis-related Organ Failure Assessment (qSOFA), using statistical and machine learning approaches. Methods: This retrospective study examined patient visits in Emergency Department (ED) with sepsis related diagnosis. The outcome was 28-day in-hospital mortality. Using odds ratio (OR) and modeling methods (decision tree [DT], multivariate logistic regression [LR], and naïve Bayes [NB]), the relationships between diagnostic criteria and mortality were examined...
April 2018: Healthcare Informatics Research
https://www.readbyqxmd.com/read/29768624/analysis-of-the-immunological-biomarker-profile-during-acute-zika-virus-infection-reveals-the-overexpression-of-cxcl10-a-chemokine-linked-to-neuronal-damage
#8
Felipe Gomes Naveca, Gemilson Soares Pontes, Aileen Yu-Hen Chang, George Allan Villarouco da Silva, Valdinete Alves do Nascimento, Dana Cristina da Silva Monteiro, Marineide Souza da Silva, Lígia Fernandes Abdalla, João Hugo Abdalla Santos, Tatiana Amaral Pires de Almeida, Matilde Del Carmen Contreras Mejía, Tirza Gabrielle Ramos de Mesquita, Helia Valeria de Souza Encarnação, Matheus de Souza Gomes, Laurence Rodrigues Amaral, Ana Carolina Campi-Azevedo, Jordana Graziela Coelho-Dos-Reis, Lis Ribeiro do Vale Antonelli, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Rajendranath Ramasawmy
BACKGROUND: Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis. OBJECTIVES: To define the immunologic biomarkers that correlate with acute ZIKV infection. METHODS: We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining...
May 14, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29765455/ringer-s-lactate-solution-enhances-the-inflammatory-response-during-fluid-resuscitation-of-experimentally-induced-haemorrhagic-shock-in-rats
#9
Krzysztof Kusza, Mariusz Mielniczuk, Lukasz Krokowicz, Jacek B Cywiński, Maria Siemionow
Introduction: Hemorrhagic shock leads to systemic oxygen deficit (hypoxaemia) that results in systemic inflammatory response syndrome (SIRS), a recognised cause of late mortality in this case. The aim of this study was to analyse the impact of fluid resuscitation, using two Ringer solutions, on the microcirculation changes that take place during experimentally induced haemorrhagic shock. Material and methods: A model of the rat cremaster muscle was used to assess microcirculation in vivo ...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29764548/-effects-of-different-core-temperatures-after-heat-strike-on-serum-inflammatory-cytokines-and-multiple-organ-dysfunction-syndrome-in-rats
#10
Qinghua Li, Rongqing Sun, Hongdi Lyu, Dexin Shen, Qing Hu, Haiwei Wang, Nannan Wang, Jin Yan, Jing Wang
OBJECTIVE: To observe the effect of different core temperatures (Tc) after heat strike on serum inflammatory cytokines and multiple organ dysfunction syndrome (MODS) in rat. METHODS: 120 male Sprague-Dawley (SD) rats were randomly divided into normal control group (n = 30) and heat strike group (n = 90). The rats in heat strike group were put into simulated thermal climate animal module after adaptive training. The module temperature was raised to 39 centigrade in 30 minutes with 65% humidity...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29764457/video-mediastinoscopy-assisted-fish-bone-extraction-and-superior-medistinal-abscess-debridement
#11
Jun Wang, Wei Bing Wu, Liang Chen, Quan Zhu
BACKGROUND: Mediastinum abscess caused by sharp esophageal foreign body perforation usually needs surgical treatment, and the surgical procedures vary according to size of perforation and scope of abscess, etc. For special case with small esophageal mucosal crevasse and focal abscess confined to mediastinum, minimally invasive surgery with guidance of video-mediastinoscopy would be an alternative method, however, application of video-mediastinoscopy in this life-threatening situation was rarely reported...
May 15, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29763753/a-prospective-study-of-cancer-survivors-and-risk-of-sepsis-within-the-regards-cohort
#12
Justin Xavier Moore, Tomi Akinyemiju, Alfred Bartolucci, Henry E Wang, John Waterbor, Russell Griffin
BACKGROUND: Hospitalized cancer patients are nearly 10 times more likely to develop sepsis when compared to patients with no cancer history. We compared the risk of sepsis between cancer survivors and no cancer history participants, and examined whether race was an effect modifier. METHODS: We performed a prospective analysis of data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. We categorized participants as "cancer survivors" or "no cancer history" derived from self-reported responses of being diagnosed with any cancer, excluding non-melanoma skin cancer...
May 11, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29761267/porcine-fc%C3%AE%C2%B5ri-mediates-porcine-reproductive-and-respiratory-syndrome-virus-multiplication-and-regulates-the-inflammatory-reaction
#13
Peidian Shi, Lilin Zhang, Jiashun Wang, Dong Lu, Yi Li, Jie Ren, Menglu Shen, Lei Zhang, Jinhai Huang
Porcine reproductive and respiratory syndrome virus (PRRSV) shows characteristic antibody-dependent enhancement (ADE) of infection and causes porcine systemic inflammation, which is similar to a type I allergic reaction; however, the role of porcine FcεRI in ADE is still unclear. In this study, the expression of different Fc receptors (FcRs) on macrophages was investigated in a PRRSV 3D4/21 cell infection model in the presence or absence of PRRSV antibody. The transcription level of FcγII and FcεRI was significantly up-regulated under PRRSV-antibody complex infection...
May 14, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29760745/diagnostic-value-of-decoy-receptor-3-combined-with-procalcitonin-and-soluble-urokinase-type-plasminogen-activator-receptor-for-sepsis
#14
Jing-Jing Zhao, Xiao-Li Lou, Hong-Wei Chen, Feng-Ting Zhu, Yan-Qiang Hou
The levels of decoy receptor 3 (DcR3), soluble urokinase type plasminogen activator receptor (suPAR) and procalcitonin (PCT) are significantly increased in sepsis. We investigated the diagnostic value of DcR3 combined with suPAR and PCT in sepsis. Patients with sepsis, non-infectious systemic inflammatory response comprehensive syndrome (SIRS) and healthy controls were recruited according to the diagnostic standard. We measured DcR3, suPAR, PCT, interleukin-6 (IL-6) and C-reactive protein (CRP), and the diagnostic value was evaluated by receiver operating characteristics (ROC) curves...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29754857/comparison-of-normal-saline-versus-lactated-ringer-s-solution-for-fluid-resuscitation-in-patients-with-mild-acute-pancreatitis-a-randomized-controlled-trial
#15
Sararak Choosakul, Kamin Harinwan, Sakkarin Chirapongsathorn, Krit Opuchar, Theeranun Sanpajit, Wanich Piyanirun, Chaipichit Puttapitakpong
BACKGROUND/OBJECTIVES: Aggressive fluid resuscitation is recommended for initial management of acute pancreatitis. However, there are few studies which focus on types of fluid therapy. METHODS: We performed a randomized controlled trial in patients with acute pancreatitis. The patients were randomized into two groups. Each group received Normal Saline solution (NSS) or Lactated Ringer's solution (LRS) through a goal-directed fluid resuscitation protocol. Systemic inflammatory response syndrome (SIRS) at 24 and 48 h, mortality, presence of local complications and inflammatory markers were measured...
May 7, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29754152/brain-natriuretic-peptide-regulated-expression-of-inflammatory-cytokines-in-lipopolysaccharide-lps-activated-macrophages-via-nf-%C3%AE%C2%BAb-and-mitogen-activated-protein-kinase-mapk-pathways
#16
Xiong Li, Hao Peng, Jiongxing Wu, Yangcheng Xu
BACKGROUND This study aimed to investigate the effects of recombinant human brain natriuretic peptide (rhBNP) on IL-6, TNF-α, and IL-10 secretion in LPS-activated RAW 264.7 cells and human peripheral blood mononuclear cells (PBMCs) in vitro and to explore the related signaling pathways of the regulation mechanisms of BNP in systemic inflammatory response syndrome (SIRS). MATERIAL AND METHODS MTT assay was used to evaluate the effects of rhBNP on cell viabilities. Lipopolysaccharide (LPS) was used to induce inflammation response...
May 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29753616/an-interoperable-clinical-decision-support-system-for-early-detection-of-sirs-in-pediatric-intensive-care-using-openehr
#17
Antje Wulff, Birger Haarbrandt, Erik Tute, Michael Marschollek, Philipp Beerbaum, Thomas Jack
BACKGROUND: Clinical decision-support systems (CDSS) are designed to solve knowledge-intensive tasks for supporting decision-making processes. Although many approaches for designing CDSS have been proposed, due to high implementation costs, as well as the lack of interoperability features, current solutions are not well-established across different institutions. Recently, the use of standardized formalisms for knowledge representation as terminologies as well as the integration of semantically enriched clinical information models, as openEHR Archetypes, and their reuse within CDSS are theoretically considered as key factors for reusable CDSS...
May 9, 2018: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29749643/insulin-dysregulation-in-horses-with-systemic-inflammatory-response-syndrome
#18
François-René Bertin, Debra Ruffin-Taylor, Allison Jean Stewart
BACKGROUND: Systemic inflammation is a cause of insulin dysregulation in many species, but the insulin and glucose dynamics in adult horses diagnosed with systemic inflammatory response syndrome (SIRS) are poorly documented. HYPOTHESIS/OBJECTIVES: In SIRS in horses, insulin and glucose dynamics will be altered and associated with survival. ANIMALS: Adult horses diagnosed with SIRS admitted to a referral hospital. METHODS: Prospective study enrolling horses diagnosed with SIRS in which serum insulin and glucose concentrations were measured...
May 10, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29747642/salivary-alpha-amylase-activity-and-cortisol-in-horses-with-acute-abdominal-disease-a-pilot-study
#19
María Dolores Contreras-Aguilar, Damián Escribano, María Martín-Cuervo, Fernando Tecles, Jose Joaquín Cerón
BACKGROUND: The aim of this study was to evaluate salivary alpha-amylase (sAA), considered a non-invasive biomarker for sympathetic nervous system (SNS) activity, and salivary cortisol as possible pain-induced stress biomarker, in horses with acute abdominal disease. Therefore, a prospective observational study was performed in which both biomarkers were analyzed in a group of horses with acute abdomen syndrome, and compared with a group of healthy control horses by an unpaired Student's t-test...
May 10, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29747233/comparison-of-endoscopic-and-percutaneous-drainage-of-symptomatic-necrotic-collections-in-acute-necrotizing-pancreatitis
#20
Shanan Woo, Ryan Walklin, Travis Ackermann, Sheng Wei Lo, Hamish Shilton, Charles Pilgrim, Peter Evans, James Burnes, Daniel Croagh
INTRODUCTION: Primary endoscopic and percutaneous drainage for pancreatic necrotic collections is increasingly used. We aim to compare the relative effectiveness of both modalities in reducing the duration and severity of illness by measuring their effects on systemic inflammatory response syndrome (SIRS). METHODS: We retrospectively reviewed all cases of endoscopic and percutaneous drainage for pancreatic necrotic collections performed in 2011-2016 at two hospitals...
May 10, 2018: Asian Journal of Endoscopic Surgery
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