keyword
https://read.qxmd.com/read/38507683/amyloid-fibrinogen-aggregates-microclots-predict-risks-of-disseminated-intravascular-coagulation-and-mortality
#21
JOURNAL ARTICLE
Jeremy Schofield, Simon Timothy Abrams, Rosalind Jenkins, Steven Lane, Guozheng Wang, Cheng-Hock Toh
Microclots have been associated with various conditions, including post-acute sequelae of SARS-CoV-2 infection. They have been postulated to be amyloid-fibrin(ogen) aggregates, but their role as a prognostic biomarker remains unclear. To examine for their possible clinical utility, blood samples were collected for the first 96 hours from critically ill patients (n=104) admitted to the intensive care unit (ICU). Detection was by staining platelet-poor plasma samples with Thioflavin T and visualized by fluorescent microscopy...
March 20, 2024: Blood Advances
https://read.qxmd.com/read/38507416/management-practices-in-facilities-providing-hiv-services-to-key-populations-in-kenya-and-malawi-a-descriptive-analysis-of-management-in-community-based-organizations
#22
JOURNAL ARTICLE
Andrea Salas-Ortiz, Marjorie Opuni, Alejandra Rodríguez-Atristain, José Luis Figeroa, Jorge Eduardo Sánchez-Morales, Agatha Kapatuka Bula, Barbara Nyambura, Sergio Bautista-Arredondo
HIV services for key populations (KP) at higher risk of HIV infection are often delivered by community-based organizations. To achieve HIV epidemic control, countries need to scale up HIV services for KP. Little is known about the management practices of community-based organizations delivering health services. We explored the management practices and facility characteristics of community-based health facilities providing HIV services to key populations as part of the LINKAGES program in Kenya and Malawi. We collected information on management practices from 45 facilities called drop-in centers (DICs) during US Government FY 2019, adapting the World Management Survey to the HIV community-based health service delivery context...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38502236/a-massive-attack-a-pediatric-case-of-macrophage-activation-syndrome-complicated-by-dic-as-an-onset-of-systemic-juvenile-idiopathic-arthritis-successfully-treated-with-anakinra-and-review-of-the-literature
#23
REVIEW
Anna Maeser, Malgorzata Biernacka-Zielinska, Elzbieta Smolewska
Macrophage activation syndrome (MAS) is one of the most severe complications of systemic juvenile idiopathic arthritis (sJIA). Around 10% of patients with sJIA exhibit systemic symptoms accompanied by macrophage activation syndrome (MAS), but it may occur subclinically in another 30-40%. In this article, we present a case of a 3-year-old girl diagnosed with sever MAS as an onset of sJIA complicated by disseminated intravascular coagulation (DIC). First symptoms of sJIA were observed about 5 months before setting the diagnose, and it was resembling urticaria...
March 19, 2024: Rheumatology International
https://read.qxmd.com/read/38501699/a-drained-nutrient-poor-peatland-forest-in-boreal-sweden-constitutes-a-net-carbon-sink-after-integrating-terrestrial-and-aquatic-fluxes
#24
JOURNAL ARTICLE
Cheuk Hei Marcus Tong, Koffi Dodji Noumonvi, Joshua Ratcliffe, Hjalmar Laudon, Järvi Järveoja, Andreas Drott, Mats B Nilsson, Matthias Peichl
Northern peatlands provide a globally important carbon (C) store. Since the beginning of the 20th century, however, large areas of natural peatlands have been drained for biomass production across Fennoscandia. Today, drained peatland forests constitute a common feature of the managed boreal landscape, yet their ecosystem C balance and associated climate impact are not well understood, particularly within the nutrient-poor boreal region. In this study, we estimated the net ecosystem carbon balance (NECB) from a nutrient-poor drained peatland forest and an adjacent natural mire in northern Sweden by integrating terrestrial carbon dioxide (CO2 ) and methane (CH4 ) fluxes with aquatic losses of dissolved organic C (DOC) and inorganic C based on eddy covariance and stream discharge measurements, respectively, over two hydrological years...
March 2024: Global Change Biology
https://read.qxmd.com/read/38494809/-a-case-of-breast-cancer-that-developed-pulmonary-tumor-thrombotic-microangiopathy-during-adjuvant-chemotherapy
#25
JOURNAL ARTICLE
Kensuke Okano, Takahiro Suzuki, Atsumi Abe, Akiko Itaya, Yuma Kameyama, Shuntaro Matsumoto, Kenichi Hakamada
A 68-year-old woman underwent neoadjuvant chemotherapy for left breast cancer(triple negative type), cT2N3cM0, cStage ⅢC, and Bt+Ax(Ⅲ). The pathological diagnosis was ypT1aN2aM0, ypStage ⅢA, ER-, PgR-, HER2 score 1+, Ki- 67 25%. Adjuvant radiotherapy(50 Gy/25 Fr)was then administered, followed by capecitabine as adjuvant chemotherapy. Dyspnea occurred during administration of capecitabine, and computed tomography(CT)and blood test results suggested drug-induced interstitial pneumonia and disseminated intravascular coagulation(DIC)...
March 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38490806/astragaloside-iv-alleviates-doxorubicin-induced-cardiotoxicity-by-inhibiting-cardiomyocyte-pyroptosis-through-the-sirt1-nlrp3-pathway
#26
JOURNAL ARTICLE
Wencong Tian, Ping Zhang, Lei Yang, Peng Song, Jia Zhao, Hongzhi Wang, Yongjie Zhao, Lei Cao
Doxorubicin (DOX) is a powerful anthracycline antineoplastic drug used to treat a wide spectrum of tumors. However, its clinical application is limited due to cardiotoxic side effects. Astragaloside IV (AS IV), one of the major compounds present in aqueous extracts of Astragalus membranaceus , possesses potent cardiovascular protective properties, but the underlying molecular mechanisms are unclear. Thus, the aim of this study was to investigate the effect of AS IV on DOX-induced cardiotoxicity (DIC). Our findings revealed that DOX induced pyroptosis through the caspase-1/gasdermin D (GSDMD) and caspase-3/gasdermin E (GSDME) pathways...
March 16, 2024: American Journal of Chinese Medicine
https://read.qxmd.com/read/38489789/sepsis-induced-coagulopathy-a-prelude-to-dic
#27
JOURNAL ARTICLE
Naveen Nathan
No abstract text is available yet for this article.
April 1, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38488036/doxorubicin%C3%A2-induced-cardiomyopathy-is-mitigated-by-empagliflozin-via-the-modulation-of-endoplasmic-reticulum-stress-pathways
#28
JOURNAL ARTICLE
Akshi Malik, Ashim K Bagchi, Davinder S Jassal, Pawan K Singal
Doxorubicin (Dox) exhibits a high efficacy in the treatment of numerous types of cancer. However, the beneficial cytotoxic effects of Dox are often accompanied by an increase in the risk of cardiotoxicity. Oxidative stress (OS) plays a key role in Dox‑induced cardiomyopathy (DIC). OS in cardiomyocytes disrupts endoplasmic reticulum (ER) function, leading to the accumulation of misfolded/unfolded proteins known as ER stress. ER stress acts as an adaptive mechanism; however, prolonged ER stress together with OS may lead to the initiation of cardiomyocyte apoptosis...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38479101/thromboelastographic-evaluation-of-the-effectiveness-of-choline-or-cdp-choline-treatment-on-endotoxin-induced-hemostatic-alterations-in-dogs
#29
JOURNAL ARTICLE
Oya Eralp Inan, Meric Kocaturk, Mehmet Cansev, Yesim Ozarda, Zeki Yilmaz, Ismail Hakki Ulus
Sepsis/endotoxemia associates with coagulation abnormalities. We showed previously that exogenous choline treatment reversed the changes in platelet count and function as well as prevented disseminated intravascular coagulation (DIC) in endotoxemic dogs. The aim of this follow-up study was to evaluate the effect of treatment with choline or cytidine-5'-diphosphocholine (CDP-choline), a choline donor, on endotoxin-induced hemostatic alterations using thromboelastography (TEG). Dogs were randomized to six groups and received intravenously (iv) saline, choline (20 mg/kg) or CDP-choline (70 mg/kg) in the control groups, whereas endotoxin (0...
March 4, 2024: Research in Veterinary Science
https://read.qxmd.com/read/38475857/deep-learning-based-predictive-classification-of-functional-subpopulations-of-hematopoietic-stem-cells-and-multipotent-progenitors
#30
JOURNAL ARTICLE
Shen Wang, Jianzhong Han, Jingru Huang, Khayrul Islam, Yuheng Shi, Yuyuan Zhou, Dongwook Kim, Jane Zhou, Zhaorui Lian, Yaling Liu, Jian Huang
BACKGROUND: Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) play a pivotal role in maintaining lifelong hematopoiesis. The distinction between stem cells and other progenitors, as well as the assessment of their functions, has long been a central focus in stem cell research. In recent years, deep learning has emerged as a powerful tool for cell image analysis and classification/prediction. METHODS: In this study, we explored the feasibility of employing deep learning techniques to differentiate murine HSCs and MPPs based solely on their morphology, as observed through light microscopy (DIC) images...
March 13, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38473674/the-influence-of-flame-exposure-and-solid-particle-erosion-on-tensile-strength-of-cfrp-substrate-with-manufactured-protective-coating
#31
JOURNAL ARTICLE
Przemysław Golewski, Michał Budka
This paper presents the results of laboratory tests for new materials made of a carbon fibre-reinforced polymer (CFRP) composite with a single-sided protective coating. The protective coatings were made of five different powders-Al2 O3 , aluminium, quartz sand, crystalline silica and copper-laminated in a single process during curing of the prepreg substrate with an epoxy matrix. The specimens were subjected to flame exposure and solid particle erosion tests, followed by uniaxial tensile tests. A digital image correlation (DIC) system was used to observe the damage location and deformation of the specimens...
March 5, 2024: Materials
https://read.qxmd.com/read/38473581/effect-of-steel-fibers-on-tensile-properties-of-ultra-high-performance-concrete-a-review
#32
REVIEW
Wanghui Du, Feng Yu, Liangsheng Qiu, Yixuan Guo, Jialiang Wang, Baoguo Han
Ultra-high-performance concrete (UHPC) is an advanced cement-based material with excellent mechanical properties and durability. However, with the improvement of UHPC's compressive properties, its insufficient tensile properties have gradually attracted attention. This paper reviews the tensile properties of steel fibers in UHPC. The purpose is to summarize the existing research and to provide guidance for future research. The relevant papers were retrieved through three commonly used experimental methods for UHPC tensile properties (the direct tensile test, flexural test, and splitting test), and classified according to the content, length, type, and combination of the steel fibers...
February 28, 2024: Materials
https://read.qxmd.com/read/38473522/design-and-material-characterization-of-an-inflatable-vaginal-dilator
#33
JOURNAL ARTICLE
Po-Han Chen, Yu Ming Li, Karcher Morris, Milan T Makale, Jyoti Mayadev, Frank E Talke
There are more than 13,000 new cases of cervical cancer each year in the United States and approximately 245,000 survivors. External beam radiation and brachytherapy are the front-line treatment modalities, and 60% of patients develop vaginal damage and constriction, i.e., stenosis of the vaginal vault, greatly impeding sexual function. The incidence of vaginal stenosis (VS) following radiotherapy (RT) for anorectal cancer is 80%. VS causes serious quality of life (QoL) and psychological issues, and while standard treatment using self-administered plastic dilators is effective, acceptance and compliance are often insufficient...
February 24, 2024: Materials
https://read.qxmd.com/read/38461978/connectivity-of-floodplain-influences-riverine-carbon-outgassing-and-dissolved-carbon-transport
#34
JOURNAL ARTICLE
Y Jun Xu, Zhen Xu, Lee Potter
Rivers not only function as a conduit for the delivery of terrestrial constituents to oceans, but they also serve as an essential medium for biogeochemical processing of the constituents. While extensive research has been conducted on carbon transport in many rivers, little is known about carbon transformation in engineered rivers reconnected with their floodplain network. Being the largest distributary of the levee-confined Mississippi River (MR), the Atchafalaya River (AR) carries 25 % of the MR water, flowing through North America's largest freshwater swamp basin and emptying into the Gulf of Mexico...
March 8, 2024: Science of the Total Environment
https://read.qxmd.com/read/38458046/nanomedicine-alleviates-doxorubicin-induced-cardiotoxicity-and-enhances-chemotherapy-synergistic-chemodynamic-therapy
#35
JOURNAL ARTICLE
Yaqian He, Xiaoying Liu, Zichuang Xu, Jiajun Gao, Qingzhi Luo, Yuchu He, Xuwu Zhang, Dawei Gao, Desong Wang
Doxorubicin (DOX) is widely used in clinic as a broad-spectrum chemotherapy drug, which can enhance the efficacy of chemodynamic therapy (CDT) by interfering tumor-related metabolize to increase H2 O2 content. However, DOX can induce serious cardiomyopathy (DIC) due to its oxidative stress in cardiomyocytes. Eliminating oxidative stress would create a significant opportunity for the clinical application of DOX combined with CDT. To address this issue, we introduced sodium ascorbate (AscNa), the main reason is that AscNa can be catalyzed to produce H2 O2 by the abundant Fe3+ in the tumor site, thereby enhancing CDT...
March 4, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38457881/impact-of-pesticides-on-marine-coral-reef-foraminifera
#36
JOURNAL ARTICLE
Michael Lintner, Michael Schagerl, Bianca Lintner, Wolfgang Wanek, Jan Goleń, Jarosław Tyszka, Petra Heinz
Our laboratory study looked into how pesticides affect the foraminifera species Heterostegina depressa and their obligatory algal endosymbionts. We incubated the foraminifera separately with different types of pesticides at varying concentrations (1 %, 0.01 % and 0.0001 %); we included the insecticide Confidor© (active substance: imidacloprid), the fungicide Pronto©Plus (tebuconazole), and the herbicide Roundup© (glyphosate). Our evaluation focused on the symbiont's photosynthetically active area (PA), and the uptake of dissolved inorganic carbon (DIC) and nitrogen (nitrate) to determine the vitality of the foraminifera...
March 7, 2024: Marine Pollution Bulletin
https://read.qxmd.com/read/38456997/neutrophil-extracellular-traps-mediate-cardiomyocyte-ferroptosis-via-the-hippo-yap-pathway-to-exacerbate-doxorubicin-induced-cardiotoxicity
#37
JOURNAL ARTICLE
Peng Zhao, You Li, Xiangli Xu, Haobo Yang, Xintong Li, Shuai Fu, Zihong Guo, Jianing Zhang, Hairu Li, Jiawei Tian
Doxorubicin-induced cardiotoxicity (DIC), which is a cardiovascular complication, has become the foremost determinant of decreased quality of life and mortality among survivors of malignant tumors, in addition to recurrence and metastasis. The limited ability to accurately predict the occurrence and severity of doxorubicin-induced injury has greatly hindered the prevention of DIC, but reducing the dose to mitigate side effects may compromise the effective treatment of primary malignancies. This has posed a longstanding clinical challenge for oncologists and cardiologists...
March 8, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38452037/comparison-of-five-different-disseminated-intravascular-coagulation-criteria-in-predicting-mortality-in-patients-with-sepsis
#38
JOURNAL ARTICLE
Amara Zafar, Filza Naeem, Muhammad Zain Khalid, Safia Awan, Muhammad Mehmood Riaz, Saad Bin Zafar Mahmood
OBJECTIVE: Even though patients with sepsis and DIC have a higher mortality rate compared to those without DIC, screening for DIC is not currently part of sepsis management protocols. This may be due to a lack of literature on the frequency of DIC occurrence in sepsis patients, as well as the absence of evidence on the optimal DIC criteria to use for identifying DIC and predicting mortality among the five criteria available. To address this gap, this study investigates the predictive value of five different criteria for diagnosing DIC and its relationship to patient outcomes in our population of sepsis patients...
2024: PloS One
https://read.qxmd.com/read/38448643/influence-of-remodeled-ecm-and-co-culture-with-ipsc-derived-cardiac-fibroblasts-on-the-mechanical-function-of-micropatterned-ipsc-derived-cardiomyocytes
#39
JOURNAL ARTICLE
A Stempien, M Josvai, J Notbohm, J Zhang, T J Kamp, W C Crone
INTRODUCTION: In native heart tissue, functions of cardiac fibroblasts (CFs) include synthesis, remodeling, and degradation of the extracellular matrix (ECM) as well as secreting factors that regulate cardiomyocyte (CM) function. The influence of direct co-culture and CF-derived ECM on CM mechanical function are not fully understood. METHODS: Here we use an engineered culture platform that provides control over ECM geometry and substrate stiffness to evaluate the influence of iPSC-CFs, and the ECM they produce, on the mechanical function of iPSC-CMs...
March 6, 2024: Cardiovascular Engineering and Technology
https://read.qxmd.com/read/38440072/autoimmune-findings-in-patients-with-silicosis-in-spain
#40
JOURNAL ARTICLE
Coral González Fernández, Jose Antonio Ros Lucas, Maria Molina Molina, Juan Rigual Bobillo, Rogelio Alejandro García Montenegro, Raquel Fernández González, Ana Jaureguiza Oriol, Jose Abal Arca
BACKGROUND: Occupational exposure to silica is related to autoimmune diseases and features of autoimmunity, mainly autoantibodies. The study objectives were to estimate the prevalence of silicosis with associated autoimmune findings or diagnosed autoimmune diseases in Spain, and to assess the clinical and functional characteristics of affected patients. METHODS: This is a multicentre prospective study in patients diagnosed with silicosis. Autoantibodies analysed were antinuclear antibodies, isotypes IgA, IgM and IgG, rheumatoid factor, anticyclic citrullinated peptide, anti-Scl70, anti-Ro, and anti-LA...
2024: Drugs in Context
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