keyword
MENU ▼
Read by QxMD icon Read
search

Dic

keyword
https://www.readbyqxmd.com/read/28422420/a-study-of-disseminated-intravascular-coagulation-in-acute-leukemia-reveals-markedly-elevated-d-dimer-levels-are-a-sensitive-indicator-of-acute-promyelocytic-leukemia
#1
N Shahmarvand, J S Oak, M J Cascio, M Alcasid, E Goodman, B C Medeiros, D A Arber, J L Zehnder, R S Ohgami
INTRODUCTION: While the presence of disseminated intravascular coagulation (DIC) has been implicated in worse clinical outcome in acute leukemia, the relationship between different subtypes of acute leukemia and the clinicopathologic features of DIC has not been systematically well studied. METHODS: In this study, we retrospectively reviewed 149 cases of newly diagnosed acute leukemia and assessed the utility of evaluating red blood cell morphologic features, and coagulation parameters in determining the presence of DIC as well as differentiating subtypes of acute leukemia...
April 19, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28420841/tranexamic-acid-controlled-chronic-disseminated-intravascular-coagulation-associated-with-aortic-dissection-and-patent-false-lumen-for-three-years
#2
Yodo Gatate, Nobuyuki Masaki, Atsushi Sato, Risako Yasuda, Takayuki Namba, Hirotaka Yada, Akio Kawamura, Takeshi Adachi
The management of chronic disseminated intravascular coagulation (DIC) caused by aortic dissection has not yet been established. Even in cases where surgical correction is performed, therapeutic control of systemic hemorrhaging is still required. We herein report the successful treatment of a case of aortic dissection with a patent false lumen using tranexamic acid for acute exacerbation of chronic DIC. Oral administration of 1,500 mg tranexamic acid per day stabilized the coagulative and fibrinolytic parameters and relieved bleeding tendencies with no side effects...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28420603/the-coags-uncomplicated-app-fulfilling-educational-gaps-around-diagnosis-and-laboratory-testing-of-coagulation-disorders
#3
Craig Kessler, Ellinor I Peerschke, Meera B Chitlur, Roshni Kulkarni, Natalia Holot, David L Cooper
BACKGROUND: Patients with coagulation disorders may present to a variety of physician specialties; however, accurate and efficient diagnosis can be challenging for physicians not specialized in hematology, due to identified gaps in knowledge around appropriate laboratory assays and interpretation of test results. Coags Uncomplicated was developed to fill this unmet educational need by increasing practical knowledge of coagulation disorders among nonexpert physicians and other health care professionals (HCPs) in a point-of-care (POC) setting...
April 18, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/28412927/widespread-subcutaneous-necrosis-in-spotted-fever-group-rickettsioses-from-the-coastal-belt-of-sri-lanka-a-case-report
#4
Nathasha Luke, Hasini Munasinghe, Lakshmi Balasooriya, Ranjan Premaratna
BACKGROUND: Spotted fever group rickettsioses (SFGR) transmitted mostly by ticks are increasingly discovered around the World and some of them are either re-emerging or emerging in Sri Lanka. Accidental human infections caused by these vector borne zoonotic diseases generally give rise to nonspecific acute febrile illnesses which can be complicated by multi organ involvement carrying high morbidity and mortality. Nonspecific clinical features and non-availability of early diagnostic facilities are known to result in delay in the diagnosis of rickettsial infections...
April 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28400101/overcoming-the-exacerbating-effects-of-ranitidine-on-nsaid-induced-small-intestinal-toxicity-with-quercetin-providing-a-complete-gi-solution
#5
Devendra Pratap Singh, Swapnil P Borse, Manish Nivsarkar
There is a need to find/discover novel leads to treat complex and/or multi-factorial-pathogenic disease(s) like Nonsteroidal anti-inflammatory drugs (NSAID)-induced gastroenteropathy or gastrointestinal (GI) toxicity as it has emerged as an important medical and socioeconomic problem. There is no approved therapeutic strategy to prevent NSAID-induced small intestinal toxicity and highly effective gastro-protective drugs such as ranitidine hydrochloride (RAN) exacerbate it. In this purview, the multi target drug discovery approach (MTDD), combination approach and hit to lead strategies based on the foundation of ethnopharmacology and/or reverse pharmacology holds strong potential...
April 8, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28398591/evolutionarily-distinct-strategies-for-the-acquisition-of-inorganic-carbon-from-seawater-in-marine-diatoms
#6
Yoshinori Tsuji, Anggara Mahardika, Yusuke Matsuda
The acquisition of dissolved inorganic carbon (DIC) in CO2-limited seawater is a central issue to understand in marine primary production. We previously demonstrated the occurrence of direct HCO3- uptake by solute carrier (SLC) 4 transporters in a diatom, a major marine primary producer. Homologs of SLC are found in both centric and pennate marine diatoms, suggesting that SLC transporters are generally conserved. Here, the generality of SLC-mediated DIC uptake in diatoms was examined using an SLC inhibitor, diisothiocyano-2,2'-stilbenedisulfonic acid (DIDS), and an inhibitor of external carbonic anhydrase, acetazolamide...
April 8, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28391356/rat-precision-cut-liver-slices-predict-drug-induced-cholestatic-injury
#7
Viktoriia Starokozhko, Rick Greupink, Petra van de Broek, Nashwa Soliman, Samiksha Ghimire, Inge A M de Graaf, Geny M M Groothuis
Drug-induced cholestasis (DIC) is one of the leading manifestations of drug-induced liver injury (DILI). As the underlying mechanisms for DIC are not fully known and specific and predictive biomarkers and pre-clinical models are lacking, the occurrence of DIC is often only reported when the drug has been approved for registration. Therefore, appropriate models that predict the cholestatic potential of drug candidates and/or provide insight into the mechanism of DIC are highly needed. We investigated the application of rat precision-cut liver slices (PCLS) to predict DIC, using several biomarkers of cholestasis: hepatocyte viability, intracellular accumulation of total as well as individual bile acids and changes in the expression of genes known to play a role in cholestasis...
April 8, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28386413/threshold-effect-of-growth-rate-on-population-variability-of-escherichia-coli-cell-lengths
#8
Manasi S Gangan, Chaitanya A Athale
A long-standing question in biology is the effect of growth on cell size. Here, we estimate the effect of Escherichia coli growth rate (r) on population cell size distributions by estimating the coefficient of variation of cell lengths (CVL) from image analysis of fixed cells in DIC microscopy. We find that the CVL is constant at growth rates less than one division per hour, whereas above this threshold, CVL increases with an increase in the growth rate. We hypothesize that stochastic inhibition of cell division owing to replication stalling by a RecA-dependent mechanism, combined with the growth rate threshold of multi-fork replication (according to Cooper and Helmstetter), could form the basis of such a threshold effect...
February 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28383305/a-digital-image-correlation-analysis-of-strain-generated-by-3-unit-implant-supported-fixed-dental-prosthesis-an-in-vitro-study
#9
Raniel F Peixoto, Ana P Macedo, Janisse Martinelli, Adriana C Lapria Faria, Rodrigo Tiossi, Ricardo F Ribeiro, Maria da G C de Mattos
OBJECTIVE: To evaluate the influence of different veneering materials (porcelain and resin) and implants (short and conventional) in the strain distribution of implant-supported splinted fixed partial dentures (FPDs) using digital image correlation (DIC). MATERIAL AND METHODS: Four polyurethane models were fabricated with resin replicas (first premolar) and short and/or conventional implants replacing the second premolar and first and second molars, according to the following configurations: G1, 2 conventional (second premolar and first molar) and 1 short (second molar) implant; G2, 1 conventional (second premolar) and 2 short (first and second molar) implants; G3, 3 short implants; G4, 3 conventional implants...
April 5, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28380862/phase-shifted-helical-long-period-fiber-grating-and-its-characterization-by-using-the-microscopic-imaging-method
#10
Peng Wang, Ramanathan Subramanian, Chengliang Zhu, Hua Zhao, Hongpu Li
We demonstrate a simple and robust method to write a phase-shifted helical long-period fiber grating (HLPG), where an equivalent phase-shift is formed by changing the local period of the grating during the fabrication process. Furthermore, we propose and demonstrate a simple method to characterize the phase-shift formed in a HLPG, which is realized by directly analyzing the imaging pattern of the fabricated HLPG using a stereo microscope under a white light illumination. Unlike the previous methods which are indirectly realized either by measuring the transmission spectrum of the fabricated HLPG or by analyzing the differential interference contrast (DIC) microscopic images of the fabricated HLPG, the proposed method can be used to well estimate the grating period as well as the phase-shift inserted in the HLPG in situ, which could considerably facilitate the fabrication technique of the HLPG by using CO<sub>2</sub> laser...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28375008/the-dynameomics-entropy-dictionary-a-large-scale-assessment-of-conformational-entropy-across-protein-fold-space
#11
Clare-Louise Towse, Mikael Akke, Valerie Daggett
Molecular dynamics (MD) simulations contain considerable information with regard to the mo-tions and fluctuations of a protein, the magnitude of which can be used to estimate conforma-tional entropy. Here we survey conformational entropy across protein fold space using the Dy-nameomics database, which represents the largest existing dataset of protein MD simulations for representatives of essentially all known protein folds. We provide an overview of MD-derived entropies accounting for all possible degrees of dihedral freedom on an unprecedented scale...
April 4, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28371723/in-vitro-drug-interaction-of-levocetirizine-and-diclofenac-theoretical-and-spectroscopic-studies
#12
Ahmed S Abo Dena, Sara A Abdel Gaber
Levocetirizine dihydrochloride is known to interact with some anti-inflammatory drugs. We report here a comprehensive integrated theoretical and experimental study for the in vitro drug interaction between levocetirizine dihydrochloride (LEV) and diclofenac sodium (DIC). The interaction of the two drugs was confirmed by the molecular ion peak obtained from the mass spectrum of the product. Moreover, FTIR and (1)HNMR spectra of the individual drugs and their interaction product were inspected to allocate the possible sites of interaction...
March 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28369501/in-synechococcus-sp-competition-for-energy-between-assimilation-and-acquisition-of-c-and-those-of-n-only-occurs-when-growth-is-light-limited
#13
Zuoxi Ruan, John A Raven, Mario Giordano
The carbon-concentrating mechanisms (CCMs) of cyanobacteria counteract the low CO2 affinity and CO2:O2 selectivities of the Rubisco of these photolithotrophs and the relatively low oceanic CO2 availability. CCMs have a significant energy cost; if light is limiting, the use of N sources whose assimilation demands less energy could permit a greater investment of energy into CCMs and inorganic C (Ci) assimilation. To test this, we cultured Synechococcus sp. UTEX LB 2380 under either N or energy limitation, in the presence of NO3- or NH4+...
March 28, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28368336/serum-concentrations-of-angiopoietin-2-and-soluble-fms-like-tyrosine-kinase-1-sflt-1-are-associated-with-coagulopathy-among-patients-with-acute-pancreatitis
#14
Paulina Dumnicka, Beata Kuśnierz-Cabala, Mateusz Sporek, Małgorzata Mazur-Laskowska, Krzysztof Gil, Marek Kuźniewski, Piotr Ceranowicz, Zygmunt Warzecha, Artur Dembiński, Joanna Bonior, Ryszard Drożdż
In severe acute pancreatitis (SAP), systemic inflammation leads to endothelial dysfunction and activation of coagulation. Thrombotic disorders in acute pancreatitis (AP) include disseminated intravascular coagulation (DIC). Recently, angiopoietin-2 and soluble fms-like tyrosine kinase 1 (sFlt-1) were proposed as markers of endothelial dysfunction in acute states. Our aim was to assess the frequency of coagulation abnormalities in the early phase of AP and evaluate the relationships between serum angiopoietin-2 and sFlt-1 and severity of coagulopathy...
April 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28368177/testing-small-variance-priors-using-prior-posterior-predictive-p-values
#15
Herbert Hoijtink, Rens van de Schoot
Muthén and Asparouhov (2012) propose to evaluate model fit in structural equation models based on approximate (using small variance priors) instead of exact equality of (combinations of) parameters to zero. This is an important development that adequately addresses Cohen's (1994) The Earth is Round (p < .05), which stresses that point null-hypotheses are so precise that small and irrelevant differences from the null-hypothesis may lead to their rejection. It is tempting to evaluate small variance priors using readily available approaches like the posterior predictive p value and the DIC...
April 3, 2017: Psychological Methods
https://www.readbyqxmd.com/read/28366841/digital-image-correlation-aided-mechanical-characterization-of-the-anteromedial-and-posterolateral-bundles-of-the-anterior-cruciate-ligament
#16
Kaitlyn Mallett, Ellen M Arruda
The anterior cruciate ligament (ACL) is one of the most commonly injured soft tissue structures in the articular knee joint, often requiring invasive surgery for patients to restore pre-injury knee kinematics. There is a pressing need to understand the role of the ACL in knee function, in order to select proper replacements. Digital image correlation (DIC), a non-contact full field displacement measurement technique, is an established tool for evaluating non-biological materials. The application of DIC to soft tissues has been in the nascent stages, largely due to patterning challenges of such materials...
March 30, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28363081/proposal-and-application-of-a-novel-disseminated-intravascular-coagulation-scoring-system-in-the-florida-manatee-trichechus-manatus-latirostris
#17
Ashley Barratclough, Ray L Ball, Ruth Francis Floyd, Roger L Reep, Bobbi J Conner
  Disseminated intravascular coagulopathy (DIC) is an acquired disorder of hemostasis resulting in activation of the coagulation and fibrinolytic pathways. It is reported secondarily to multiple disease processes and can be associated with increased mortality. Previous research at Tampa's Lowry Park Zoo (LPZ) demonstrated that Florida manatees ( Trichechus manatus latirostris) with cold stress syndrome (CSS) demonstrated thromboembolic disease. The object of this retrospective study was to establish the presence and clinical relevance of DIC in Florida manatees admitted to LPZ for rehabilitation from 07 March 2010 to 15 August 2015...
March 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28355601/a-revised-fibrinogen-cutoff-value-in-the-chinese-disseminated-intravascular-coagulation-scoring-system-may-provide-a-better-prognostic-value-for-hematological-malignancies
#18
Qing Wei, Ting Niu, Mengyao Wang, Jinrong Yang, Pengpeng Liu, Yuyao Yi
To retrospectively validate the prognostic value of the latest Chinese disseminated intravascular coagulation (DIC) scoring system (CDSS) in hematological malignancies, 260 patients with confirmed hematological malignancies and suspected DIC in West China Hospital between 2011 and 2015 were included in this study. We evaluated via univariate and multivariate analyses the diagnostic biomarkers, and the cutoff levels used in the CDSS, except those for fibrinogen, were found to be valid. In subgroup analyses, the value of fibrinogen was found to be mainly unfit for the acute promyelocytic leukemia group...
March 30, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/28334667/redox-controlled-release-dynamics-of-thallium-in-periodically-flooded-arable-soil
#19
Svetlana Antić-Mladenović, Tina Frohne, Mirjana Kresović, Hans-Joachim Stärk, Dubravka Savić, Vlado Ličina, Jörg Rinklebe
To our knowledge, this is the first work to mechanistically study the impact of the redox potential (EH) and principal factors, such as pH, iron (Fe), manganese (Mn), dissolved organic carbon (DOC), dissolved inorganic carbon (DIC), chlorides (Cl(-)) and sulfates (SO4(2-)), on the release dynamics of thallium (Tl) in periodically flooded soil. We simulated flooding using an automated biogeochemical microcosm system that allows for systematical control of pre-defined redox windows. The EH value was increased mechanistically at intervals of approximately 100 mV from reducing (-211 mV) to oxidizing (475 mV) conditions...
March 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28306642/damage-identification-on-vertebral-bodies-during-compressive-loading-using-digital-image-correlation
#20
Hannah M Gustafson, Angela D Melnyk, Gunter P Siegmund, Peter A Cripton
STUDY DESIGN: Ex vivo compression experiments on isolated cadaveric vertebrae OBJECTIVE.: To qualitatively compare the fracture locations identified in video analysis with the locations of high compressive strain measured with DIC on vertebral bodies and to evaluate the timing of local damage to the cortical shell relative to the global yield force SUMMARY OF BACKGROUND DATA.: In previous ex vivo experiments, cortical bone fracture has been identified using various methods including acoustic emission sensors, strain gages, video analysis, or force signals...
March 16, 2017: Spine
keyword
keyword
14567
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"