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https://www.readbyqxmd.com/read/27911450/uveal-melanoma-relatively-rare-but-deadly-cancer
#1
REVIEW
S Kaliki, C L Shields
Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most common primary intraocular tumor in adults with a mean age-adjusted incidence of 5.1 cases per million per year. Tumors are located either in iris (4%), ciliary body (6%), or choroid (90%). The host susceptibility factors for uveal melanoma include fair skin, light eye color, inability to tan, ocular or oculodermal melanocytosis, cutaneous or iris or choroidal nevus, and BRCA1-associated protein 1 mutation...
December 2, 2016: Eye
https://www.readbyqxmd.com/read/27903184/microinvasive-tumor-endoresection-in-combination-with-ocular-stereotactic-radiosurgery
#2
Oleg A Sinyavskiy, Roman L Troyanovsky, Pavel I Ivanov, Alexandr S Golovin, Andrey V Tibilov, Svetlana N Solonina, Anna M Astapenko, Irina S Zubatkina
OBJECTIVE The use of Gamma Knife radiosurgery (GKRS) as monotherapy in the treatment of uveal melanoma (UM) allows clinicians to achieve high local tumor control with low recurrence but does not prevent secondary enucleation due to glaucoma in cases of large tumors. The authors analyzed indications for tumor endoresection (ER), the time interval between irradiation and surgery, and the features and results of performing ER for UM after GKRS. METHODS Thirty-seven patients between 28 and 78 years of age (16 male and 11 female patients) with UM underwent GKRS with a dose of 70 to 80 Gy that was applied to the center of the tumor with complete immobilization of the eye during the procedure...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27851881/magnetic-resonance-safety-and-compatibility-of-tantalum-markers-used-in-proton-beam-therapy-for-intraocular-tumors-a-7-0-tesla-study
#3
Eva Oberacker, Katharina Paul, Till Huelnhagen, Celal Oezerdem, Lukas Winter, Andreas Pohlmann, Laura Boehmert, Oliver Stachs, Jens Heufelder, Andreas Weber, Matus Rehak, Ira Seibel, Thoralf Niendorf
PURPOSE: Proton radiation therapy (PRT) is a standard treatment of uveal melanoma. PRT patients undergo implantation of ocular tantalum markers (OTMs) for treatment planning. Ultra-high-field MRI is a promising technique for 3D tumor visualization and PRT planning. This work examines MR safety and compatibility of OTMs at 7.0 Tesla. METHODS: MR safety assessment included deflection angle measurements (DAMs), electromagnetic field (EMF) simulations for specific absorption rate (SAR) estimation, and temperature simulations for examining radiofrequency heating using a bow-tie dipole antenna for transmission...
November 10, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27698609/epidemiological-analysis-of-ocular-melanoma-in-university-clinic-center-in-tuzla-bosnia-and-herzegovina
#4
Amra Nadarevic Vodencarevic, Vahid Jusufovic, Svjetlana Terzic, Musfaha Burgic, Meliha Halibasic, Mersiha Sinanovic
AIM: Melanoma represents a malignant tumour arising from melanocytes. Uveal melanoma is the most common primary ocular malignancy among the adult population. The aim of the study was to examine epidemiological characteristics of ocular melanoma in University Clinic Centre in Tuzla, Bosnia and Herzegovina from January 2001 till November 2015. METHODS AND MATERIALS: In this retrospective study we used all available medical documentation to investigate the clinical findings which included age, gender, tumour size, histopathological features and the precise anatomic origin of the ocular melanoma...
July 24, 2016: Materia Socio-medica
https://www.readbyqxmd.com/read/27662779/ocular-disposition-of-treosulfan-and-its-active-epoxy-transformers-following-intravenous-administration-in-rabbits
#5
Michał Romański, Anna Kasprzyk, Agnieszka Karbownik, Franciszek K Główka
Treosulfan (TREO) has an established position in chemotherapy of advanced ovarian cancer but has been also applied in uveal melanoma patients. Moreover, it is used as an orphan drug for a myeloablative conditioning prior to stem cell transplantation. In this paper, biodistribution of prodrug TREO and its active monoepoxide (S,S-EBDM) and diepoxide (S,S-DEB) into aqueous humor of the eye was studied for the first time. For that purpose, alone TREO and the mixture of TREO, S,S-EBDM and S,S-DEB were administered intravenously to New Zealand White rabbits...
October 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27558251/proton-therapy-for-the-management-of-uveal-melanoma-and-other-ocular-tumors
#6
Kavita K Mishra, Inder K Daftari
Proton beam radiotherapy of uveal melanoma and other malignant and benign ocular tumors has shown tremendous development and success over the past four decades. Proton beam is associated with the lowest overall risk of local tumor recurrence in uveal melanoma, compared with other eye-conserving forms of primary treatment. Proton beam is also utilized for other malignant and benign tumors as primary, salvage, or adjuvant treatment with combined modality therapy. The physical characteristics of proton therapy allows for uniform dose distribution, minimal scatter, and sharp dose fall off making it an ideal therapy for ocular tumors in which critical structures lay in close proximity to the tumor...
August 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27499370/comparison-between-beta-radiation-dose-distribution-due-to-ldr-and-hdr-ocular-brachytherapy-applicators-using-gate-monte-carlo-platform
#7
Laoues Mostafa, Khelifi Rachid, Sidi Moussa Ahmed
Eye applicators with 90Sr/90Y and 106Ru/106Rh beta-ray sources are generally used in brachytherapy for the treatment of eye diseases as uveal melanoma. Whenever, radiation is used in treatment, dosimetry is essential. However, knowledge of the exact dose distribution is a critical decision-making to the outcome of the treatment. The Monte Carlo technique provides a powerful tool for calculation of the dose and dose distributions which helps to predict and determine the doses from different shapes of various types of eye applicators more accurately...
August 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27426931/impact-of-macrophages-on-tumor-growth-characteristics-in-a-murine-ocular-tumor-model
#8
Marta M Stei, Karin U Loeffler, Christian Kurts, Tobias Hoeller, Christiane Pfarrer, Frank G Holz, Martina C Herwig-Carl
Tumor associated macrophages (TAM), mean vascular density (MVD), PAS positive extravascular matrix patterns, and advanced patients' age are associated with a poor prognosis in uveal melanoma. These correlations may be influenced by M2 macrophages and their cytokine expression pattern. Thus, the effect of TAM and their characteristic cytokines on histologic tumor growth characteristics were studied under the influence of age. Ninety five CX3CR1(+/GFP) mice (young 8-12weeks, old 10-12months) received an intravitreal injection of 1 × 10(5) HCmel12 melanoma cells...
October 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27239451/lipomatous-change-in-uveal-melanoma-histopathological-immunohistochemical-and-cytogenetic-analysis
#9
Serdar Yavuzyigitoglu, Emine Kilic, Jolanda Vaarwater, Annelies de Klein, Dion Paridaens, Robert M Verdijk
PURPOSE: The aim of this study was to describe a case of lipomatous change in uveal melanoma. PROCEDURES: The patient presented with a 2-year history of blurry vision. A full examination of the right eye revealed a dome-shaped pigmented subretinal mass in the choroid with a thickness of 9 mm and a diameter of 15 mm. The eye was enucleated and prepared for histopathologic, genetic and molecular investigation. RESULTS: Histopathology revealed a small circumscribed area consisting of mature adipocytic appearing cells with abundant clear cytoplasm and small peripheral flattened nuclei within a spindle-cell melanoma of the uvea...
April 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27172390/features-of-cutaneous-malignant-melanoma-metastatic-to-the-retina-and-vitreous
#10
Mark P Breazzano, Ann E Barker-Griffith
BACKGROUND/AIMS: To report a case of cutaneous malignant melanoma with cerebral metastasis found to have vitreoretinal metastasis upon referral for neovascular glaucoma. METHODS: The clinical history and ocular examination findings, including histologic, cytologic, genetic, and immunohistochemical features of the vitreoretinal metastatic tumor, were reviewed. Additionally, the histologic and immunohistochemical features of the primary skin tumor and brain metastasis were also assessed...
December 2015: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27171429/sirt2-expression-is-higher-in-uveal-melanoma-than-in-ocular-melanocytes
#11
Danielle G Halfed, Pablo Zoroquiain, Henry A Wood, Paula Blanco, Nouf Al-Saati, Sultan Aldrees, Vasco Bravo-Filho, Miguel N Burnier
PURPOSE: Sirtuins (SIRTs) are the family of proteins associated with the cell cycle and that correlate with cancer development and progression. SIRTs have never been studied in uveal melanocytes. The aim of this study is to characterize the expression of SIRT2 in uveal melanoma (UM) cases and compare it with the expression of SIRT2 in melanocytes of the uveal tract of normal human eyes (NHE). METHODS: Twenty-one formalin-fixed, paraffin-embedded human UM cases were immunostained for SIRT2, along with 15 NHE obtained from the Eye Bank of Canada...
December 2015: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27171272/outcomes-of-proton-beam-radiotherapy-for-large-non-peripapillary-choroidal-and-ciliary-body-melanoma-at-triumf-and-the-bc-cancer-agency
#12
Britta Weber, Katherine Paton, Roy Ma, Tom Pickles
BACKGROUND AND PURPOSE: To report outcomes and toxicity after proton beam radiotherapy for non-peripapillary choroidal and ciliary body melanoma considered unsuitable for other eye-sparing therapies. MATERIALS AND METHODS: An existing database of 77 patients with non-peripapillary tumors treated at TRIUMF, Canada, including patient, tumor, and treatment characteristics, was updated with ocular complications and follow-up status from chart reviews. RESULTS: Most of the patients had large tumors: 61% were T3/T4 tumors (AJCC classification), while 48% were large by the Collaborative Ocular Melanoma Study classification...
September 2015: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27167265/ocular-brachytherapy-dosimetry-for-103pd-and-125i-in-the-presence-of-gold-nanoparticles-a-monte-carlo-study
#13
Somayeh Asadi, Mehdi Vaez-Zadeh, Mohammad Vahidian, Mahdieh Marghchouei, S Farhad Masoudi
The aim of the present Monte Carlo study is to evaluate the variation of energy deposition in healthy tissues in the human eye which is irradiated by brachytherapy sources in comparison with the resultant dose increase in the gold nanoparticle (GNP)-loaded choroidal melanoma. The effects of these nanoparticles on normal tissues are compared between 103Pd and 125I as two ophthalmic brachytherapy sources. Dose distribution in the tumor and healthy tissues has been taken into account for both brachytherapy sources...
2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27154598/melanocytic-ophthalmic-neoplasms-of-the-domestic-veterinary-species-a-review
#14
REVIEW
Annie L Wang, Thomas Kern
Melanocytic neoplasms in veterinary species occur in various ophthalmic locations including the eyelid, conjunctiva, cornea, sclera, anterior and posterior uvea, and orbit. Histology usually provides the definitive diagnosis for melanocytic ocular neoplasias. The degree of tissue invasiveness and anaplastic cellular characteristics are more reliable indicators of biological behavior than is mitotic index in most ophthalmic melanocytic tumors. Melanocytic neoplasias of the eyelid are predominantly benign in canines and equines, though in felines, there is the potential for metastasis, especially if the conjunctiva is involved...
December 2015: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/27138736/growth-and-metastasis-of-intraocular-tumors-in-aged-mice
#15
Zhiqiang Han, Joseph R Brown, Jerry Y Niederkorn
PURPOSE: Since deterioration of the immune apparatus is closely associated with cancer, we examined the effect of aging on the growth and metastasis of intraocular melanomas in mice. METHODS: Murine B16LS9 melanoma cells were transplanted into the posterior compartment of the eye (vitreous chamber) and intraocular tumor growth and development of liver metastases were evaluated in young (8-10 weeks of age) and old (>18 months of age) mice. Liver metastases were also induced by intrasplenic injection of melanoma cells...
May 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27084652/feasibility-of-proton-beam-therapy-for-ocular-melanoma-using-a-novel-3d-treatment-planning-technique
#16
William F Hartsell, Rashmi Kapur, Siobhan O'Connor Hartsell, Patrick Sweeney, Caitlin Lopes, Amanda Duggal, Jack Cohen, John Chang, Rajeev S Polasani, Megan Dunn, Mark Pankuch
PURPOSE: We evaluated sparing of normal structures using 3-dimensional (3D) treatment planning for proton therapy of ocular melanomas. METHODS AND MATERIALS: We evaluated 26 consecutive patients with choroidal melanomas on a prospective registry. Ophthalmologic work-up included fundoscopic photographs, fluorescein angiography, ultrasonographic evaluation of tumor dimensions, and magnetic resonance imaging of orbits. Three tantalum clips were placed as fiducial markers to confirm eye position for treatment...
May 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27084651/practice-patterns-analysis-of-ocular-proton-therapy-centers-the-international-optic-survey
#17
Jan Hrbacek, Kavita K Mishra, Andrzej Kacperek, Remi Dendale, Catherine Nauraye, Michel Auger, Joel Herault, Inder K Daftari, Alexei V Trofimov, Helen A Shih, Yen-Lin E Chen, Andrea Denker, Jens Heufelder, Tomasz Horwacik, Jan Swakoń, Cornelia Hoehr, Cheryl Duzenli, Alessia Pica, Farid Goudjil, Alejandro Mazal, Juliette Thariat, Damien C Weber
PURPOSE: To assess the planning, treatment, and follow-up strategies worldwide in dedicated proton therapy ocular programs. METHODS AND MATERIALS: Ten centers from 7 countries completed a questionnaire survey with 109 queries on the eye treatment planning system (TPS), hardware/software equipment, image acquisition/registration, patient positioning, eye surveillance, beam delivery, quality assurance (QA), clinical management, and workflow. RESULTS: Worldwide, 28,891 eye patients were treated with protons at the 10 centers as of the end of 2014...
May 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26910565/ocular-ultrasonography-focused-on-the-posterior-eye-segment-what-radiologists-should-know
#18
REVIEW
Marcela De La Hoz Polo, Anna Torramilans Lluís, Oscar Pozuelo Segura, Albert Anguera Bosque, Catalina Esmerado Appiani, Josep Maria Caminal Mitjana
UNLABELLED: Ocular B-mode ultrasonography (US) is an important adjuvant for the clinical assessment of a variety of ocular diseases. When ophthalmoscopy is not possible, mainly due to opacification of the transparent media (e.g., mature cataract or vitreous haemorrhage), US can guide the ophthalmologist in diagnosing disease and choosing treatment. The superficial location and cystic structure of the eye make US ideal for imaging of the eye. Moreover, dynamic study helps distinguish between various conditions that would otherwise be difficult to differentiate in some clinical setting, such as vitreous, retinal, and choroidal detachment...
June 2016: Insights Into Imaging
https://www.readbyqxmd.com/read/26840169/choroidal-melanoma-recurrence-after-episcleral-brachytherapy-and-transpupillary-thermotherapy
#19
Yrbani Lantigua-Dorville, Maria Antonia Saornil, Ciro García-Alvarez, Elena García-Lagarto
A 68-year-old man diagnosed with choroidal melanoma (CM) in the right eye underwent treatment with episcleral brachytherapy (I125) and transpupillary thermotherapy. Ultrasound, computed tomography, and magnetic resonance imaging were performed and revealed ocular recurrence of CM. Treatment with extended enucleation was performed. Macroscopic and microscopic examinations revealed extraocular extension and malignant cells, respectively. Immunohistochemistry demonstrated tumoral Melan-A and HMB-45 expression...
February 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/26655090/the-toll-like-receptor-5-agonist-entolimod-suppresses-hepatic-metastases-in-a-murine-model-of-ocular-melanoma-via-an-nk-cell-dependent-mechanism
#20
Hua Yang, Craig M Brackett, Vanessa Marie Morales-Tirado, Zezhong Li, Qing Zhang, Matthew W Wilson, Camille Benjamin, Wayne Harris, Edmund K Waller, Andrei V Gudkov, Lyudmila G Burdelya, Hans E Grossniklaus
Uveal melanoma (UM) is the most common primary cancer of the eye in adults and progresses to metastatic disease predominantly of the liver in ~50% of patients. In these cases, life expectancy averages just 9 months due to the lack of effective treatment options. The Toll-like receptor 5 (TLR5) agonist entolimod (former name CBLB502) rapidly activates TLR5-NF-κB signaling in hepatocytes and suppresses growth of both TLR5-expressing and non-expressing tumors in the liver through mobilization and activation of innate and adaptive immune mechanisms...
January 19, 2016: Oncotarget
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