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https://www.readbyqxmd.com/read/28329402/novel-orthopoxvirus-infection-in-an-alaska-resident
#1
Yuri P Springer, Christopher H Hsu, Zachary R Werle, Link E Olson, Michael P Cooper, Louisa J Castrodale, Nisha Fowler, Andrea M McCollum, Cynthia S Goldsmith, Ginny L Emerson, Kimberly Wilkins, Jeffrey B Doty, Jillybeth Burgado, JinXin Gao, Nishi Patel, Matthew R Mauldin, Mary G Reynolds, Panayampalli S Satheshkumar, Whitni Davidson, Yu Li, Joseph B McLaughlin
Background.: Human infection by orthopoxviruses is being reported with increasing frequency, attributed in part to the cessation of smallpox vaccination and concomitant waning of population-level immunity. In July 2015, a female resident of interior Alaska, presented to an urgent care clinic with a dermal lesion consistent with poxvirus infection. Laboratory testing of a virus isolated from the lesion confirmed infection by an Orthopoxvirus. Methods.: The virus isolate was characterized by using electron microscopy and nucleic acid sequencing...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28328089/capacitive-dna-sensor-for-rapid-and-sensitive-detection-of-whole-genome-human-herpes-virus-1-dsdna-in-serum
#2
Cheng Cheng, Rania Oueslati, Jayne Wu, Jiangang Chen, Shigetoshi Eda
This work presents a rapid, highly sensitive, low-cost and specific capacitive DNA sensor for detection of whole genome human herpes virus-1 DNA. This sensor is capable of direct DNA detection with a response time of 30 seconds, and it can be used to test standard buffer or serum samples. The sensing approach for DNA detection is based on AC electrokinetics. By applying an inhomogeneous AC electric field on sensor electrodes, positive dielectrophoresis is induced to accelerate DNA hybridization. The same applied AC signal also directly measures the hybridization of target with the probe on the sensor surface...
March 22, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28327111/temporal-distribution-of-gastroenteritis-viruses-in-ouagadougou-burkina-faso-seasonality-of-rotavirus
#3
Nafissatou Ouedraogo, Stephanie Moustapha Tomba Ngangas, Isidore Juste Ouindguèta Bonkoungou, Aissatou Bénéwendé Tiendrebeogo, Kuan Abdoulaye Traore, Idrissa Sanou, Alfred Sababénédjo Traore, Nicolas Barro
BACKGROUND: Acute gastroenteritis is one of the most common diseases among children and adults, and continues to cause a major problem of public health in Burkina Faso. The temporal pattern of rotavirus, norovirus, sapovirus, astrovirus, adenovirus and Aichivirus A was studied by examining prevalence of gastroenteritis viruses in association with meteorological variables in Ouagadougou, Burkina Faso. METHODS: Stool samples from 263 children under 5 years of age and 170 older children patients, adolescent and adults with gastroenteritis were collected in Ouagadougou, Burkina Faso from November 2011 to September 2012...
March 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28326827/factors-influencing-patients-receptiveness-to-evidence-based-recommendations-during-the-clinical-encounter
#4
Cara Stepanczuk, Nyna Williams, Katie Morrison, Charlene Kemmerer
AIM: To identify the factors that promote or interfere with evidence-based clinical decisions from the patient perspective. MATERIALS & METHODS: We developed four hypothetical scenarios with clinical decisions, such as whether to pursue testing for a chronic condition. We conducted eight focus groups to better understand the influences on individuals' decisions in the context of the scenarios. RESULTS: A patient's relationship with a physician emerged as the strongest influence on whether participants would accept or reject a physician's recommendation...
February 28, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28326312/a-comparison-of-published-multidimensional-indices-to-predict-outcome-in-idiopathic-pulmonary-fibrosis
#5
Charles Sharp, Huzaifa I Adamali, Ann B Millar
Idiopathic pulmonary fibrosis (IPF) has an unpredictable course and prognostic factors are incompletely understood. We aimed to identify prognostic factors, including multidimensional indices from a significant IPF cohort at the Bristol Interstitial Lung Disease Centre in the UK. Patients diagnosed with IPF between 2007 and 2014 were identified. Longitudinal pulmonary physiology and exercise testing results were collated, with all-cause mortality used as the primary outcome. Factors influencing overall, 12- and 24-month survival were identified using Cox proportional hazards modelling and receiver operating characteristic curve analysis...
January 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28326194/nurses-and-physicians-attitudes-toward-nurse-physician-collaboration-a-survey-from-gaza-strip-palestine
#6
Aymen Elsous, Mahmoud Radwan, Samah Mohsen
Interprofessional collaboration and teamwork between nurses and physicians is essential for improving patient outcomes and quality of health services. This study examined the attitudes of nurses and physicians toward nurse-physician collaboration. A cross-sectional study was conducted among nurses and physicians (n = 414) in two main referral public hospitals in the Gaza Strip using the Arabic Jefferson Scale of Attitude toward Physician-Nurse Collaboration. Descriptive statistics and difference of means, proportions, and correlations were examined using Student's t-test, one-way ANOVA, and Pearson correlation and p < 0...
2017: Nursing Research and Practice
https://www.readbyqxmd.com/read/28325368/chagas-disease-diagnostic-applications-present-knowledge-and-future-steps
#7
V Balouz, F Agüero, C A Buscaglia
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating illness of major significance throughout Latin America and an emergent threat to global public health. Being a neglected disease, the vast majority of Chagasic patients have limited access to proper diagnosis and treatment, and there is only a marginal investment into R&D for drug and vaccine development. In this context, identification of novel biomarkers able to transcend the current limits of diagnostic methods surfaces as a main priority in Chagas disease applied research...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28325018/imquant-an-image-based-fluorescence-reader-for-quantitative-lateral-flow-immunoassays
#8
Kaushik Basak Chowdhury, Jayaraj Joseph, Jayaraman Kiruthi Vasan, Mohanasankar Sivaprakasam
Fluorescence immunoassays (FIA) have strong potential in enabling rapid quantitative immunological testing at point of care. Existing state of the art instruments employ laser scanning of FIA test kits, which require the use of electromechanical systems, making the instrument bulky, heavy and less reliable in the long term. There is a growing need for an extremely compact and reliable, motion-free, automated reader for accurate quantification of immunoassays. Here, we present ImQuant, an image based FIA reader with integrated monochromatic excitation source, optical filtering and real time image capture, assisted with an intuitive graphical user interface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324325/the-universe-of-ana-testing-a-case-for-point-of-care-ana-testing
#9
Konstantin N Konstantinov, Robert L Rubin
Testing for total antinuclear antibodies (ANA) is a critical tool for diagnosis and management of autoimmune diseases at both the primary care and subspecialty settings. Repurposing of ANA from a test for lupus to a test for any autoimmune condition has driven the increase in ANA requests. Changes in ANA referral patterns include early or subclinical autoimmune disease detection in patients with low pre-test probability and use of negative ANA results to rule out underlying autoimmune disease. A positive result can lead to further diagnostic considerations...
December 2017: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/28321282/challenges-with-targeted-viral-load-testing-for-medical-inpatients-at-queen-elizabeth-central-hospital-in-blantyre-malawi
#10
Alison Craik, Priyanka Patel, Pratiksha Patel, Jane Mallewa, Ken Malisita, Joseph Bitilinyu-Bangoh, Joep J van Oosterhout, Christine Kelly
BACKGROUND: Approximately 75% of medical inpatients at Queen Elizabeth Central Hospital (QECH) in Blantyre, Malawi are HIV seropositive, and a third of these patients are on antiretroviral therapy (ART). Malawi guidelines recommend targeted viral load (VL) testing for patients on ART for at least one year who report excellent adherence and present with a WHO clinical stage 3 or 4 HIV disease. A switch to second-line ART is only indicated if a VL result >5000 copies/mL confirms treatment failure...
December 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28320794/innovative-public-private-partnership-to-target-subsidised-antimalarials-a-study-protocol-for-a-cluster-randomised-controlled-trial-to-evaluate-a-community-intervention-in-western-kenya
#11
Jeremiah Laktabai, Adriane Lesser, Alyssa Platt, Elisa Maffioli, Manoj Mohanan, Diana Menya, Wendy Prudhomme O'Meara, Elizabeth L Turner
INTRODUCTION: There are concerns of inappropriate use of subsidised antimalarials due to the large number of fevers treated in the informal sector with minimal access to diagnostic testing. Targeting antimalarial subsidies to confirmed malaria cases can lead to appropriate, effective therapy. There is evidence that community health volunteers (CHVs) can be trained to safely and correctly use rapid diagnostic tests (RDTs). This study seeks to evaluate the public health impact of targeted antimalarial subsidies delivered through a partnership between CHVs and the private retail sector...
March 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28320691/microsoft-kinect-based-continuous-performance-test-an-objective-attention-deficit-hyperactivity-disorder-assessment
#12
David Delgado-Gomez, Inmaculada Peñuelas-Calvo, Antonio Eduardo Masó-Besga, Silvia Vallejo-Oñate, Itziar Baltasar Tello, Elsa Arrua Duarte, María Constanza Vera Varela, Juan Carballo, Enrique Baca-García
BACKGROUND: One of the major challenges in mental medical care is finding out new instruments for an accurate and objective evaluation of the attention deficit hyperactivity disorder (ADHD). Early ADHD identification, severity assessment, and prompt treatment are essential to avoid the negative effects associated with this mental condition. OBJECTIVE: The aim of our study was to develop a novel ADHD assessment instrument based on Microsoft Kinect, which identifies ADHD cardinal symptoms in order to provide a more accurate evaluation...
March 20, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28320676/smartphone-based-rapid-screening-of-urinary-biomarkers
#13
Haakon Karlsen, Tao Dong
An ambulatory pre-screening Point-of-Care (POC) device compatible with commercially available diapers has been developed to rapidly screen urine samples for incontinent or functionally impaired elderly. This POC device consists of a set of colorimetric reaction pads with accompanying reference colors. A smartphone with camera is a convenient tool for analysis of colorimetric assays; and a software application has been developed for smartphones to photograph the colorimetric assay and classify colorimetric reactions according to the reference colors...
March 15, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28320384/diagnostic-accuracy-incremental-yield-and-prognostic-value-of-determine-tb-lam-for-routine-diagnostic-testing-for-tuberculosis-in-hiv-infected-patients-requiring-acute-hospital-admission-in-south-africa-a-prospective-cohort
#14
Stephen D Lawn, Andrew D Kerkhoff, Rosie Burton, Charlotte Schutz, Andrew Boulle, Monica Vogt, Ankur Gupta-Wright, Mark P Nicol, Graeme Meintjes
BACKGROUND: We previously reported that one-third of HIV-positive adults requiring medical admission to a South African district hospital had laboratory-confirmed tuberculosis (TB) and that almost two-thirds of cases could be rapidly diagnosed using Xpert MTB/RIF-testing of concentrated urine samples obtained on the first day of admission. Implementation of urine-based, routine, point-of-care TB screening is an attractive intervention that might be facilitated by use of a simple, low-cost diagnostic tool, such as the Determine TB-LAM lateral-flow rapid test for HIV-associated TB...
March 21, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28319898/immunodetection-of-salivary-biomarkers-by-an-optical-microfluidic-biosensor-with-polyethylenimine-modified-polythiophene-c70-organic-photodetectors
#15
Tao Dong, Nuno Miguel Matos Pires
This work reports a novel optical microfluidic biosensor with highly sensitive organic photodetectors (OPDs) for absorbance-based detection of salivary protein biomarkers at the point of care. The compact and miniaturized biosensor has comprised OPDs made of polythiophene-C70 bulk heterojunction for the photoactive layer; whilst a calcium-free cathode interfacial layer, made of linear polyethylenimine, was incorporated to the photodetectors to enhance the low cost. The OPDs realized onto a glass chip were aligned to antibody-functionalized chambers of a poly(methyl methacrylate) microfluidic chip, in where immunogold-silver assays were conducted...
March 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319562/translating-biomarkers-from-research-to-clinical-use-in-pediatric-neurocritical-care-focus-on-traumatic-brain-injury-and-cardiac-arrest
#16
Andrew J Prout, Michael S Wolf, Ericka L Fink
PURPOSE OF REVIEW: Traumatic brain injury (TBI) and cardiac arrest are important causes of morbidity and mortality in children. Improved diagnosis and outcome prognostication using validated biomarkers could allow clinicians to better tailor therapies for optimal efficacy. RECENT FINDINGS: Contemporary investigation has yielded plentiful biomarker candidates of central nervous system (CNS) injury, including macromolecules, genetic, inflammatory, oxidative, and metabolic biomarkers...
March 17, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28318511/effect-of-tailored-antiplatelet-therapy-to-reduce-recurrent-stent-thrombosis-and-cardiac-death-after-a-first-episode-of-stent-thrombosis
#17
Thea C Godschalk, Laura M Willemsen, Bastiaan Zwart, Thomas O Bergmeijer, Paul Willem A Janssen, Johannes C Kelder, Christian M Hackeng, Jurriën M Ten Berg
The recurrence rate of coronary stent thrombosis (ST) is high. Patients with ST often demonstrate high on-treatment platelet reactivity (HPR). It is suggested that patients at high risk of atherothrombotic events, that is patients with ST, could benefit from tailored antiplatelet therapy (APT). This study evaluated whether tailored APT, based on platelet function testing, reduced the rate of cardiac death and/or recurrent ST at 1 year after ST, compared with a historical cohort of patients with ST without tailored APT...
February 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28317969/yolk-shell-nanostructured-fe3o4-c-magnetic-nanoparticles-with-enhanced-peroxidase-like-activity-for-label-free-colorimetric-detection-of-h2o2-and-glucose
#18
Na Lu, Min Zhang, Lei Ding, Jing Zheng, Caixia Zeng, Yanli Wen, Gang Liu, Ali Aldalbahi, Jiye Shi, Shiping Song, Xiaolei Zuo, Lihua Wang
Herein, we have developed a simple and facile method to synthesize yolk-shell nanostructured Fe3O4@C nanoparticles (NPs) as a multifunctional biosensing platform for the label-free colorimetric detection of H2O2 and glucose. It was demonstrated that Fe3O4@C yolk-shell nanostructures (YSNs) retained the magnetic properties that can be used for separation and concentration. Also importantly, the Fe3O4@C YSNs exhibited an intrinsic peroxidase-like activity that could quickly catalyze the enzyme substrate in the presence of H2O2 and produce a blue color...
March 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28317003/peri-operative-inflammatory-cytokines-in-plasma-of-the-elderly-correlate-in-prospective-study-with-postoperative-changes-in-cognitive-test-scores
#19
R Kline, E Wong, M Haile, S Didehvar, S Farber, A Sacks, E Pirraglia, M J de Leon, A Bekker
Increasingly, postoperative cognitive dysfunction (POCD) is recognized as a complication after surgery in the elderly; but it's etiology remains unclear. Here we examine changes in cytokine levels during both the pre-operative and postoperative period, comparing them with long term variation in cognitive test scores. Forty-one patients aged 65 and older undergoing major surgery with general anesthesia were recruited after written consent in this IRB approved study. Thirty went on to complete this prospective, non-interven-tional and non-randomized study...
August 2016: Int J Anesthesiol Res
https://www.readbyqxmd.com/read/28306609/when-peers-count-the-effects-on-integrated-type-ii-diabetes-care-of-communication-within-general-practitioner-only-subgroups-in-interprofessional-primary-care-teams
#20
Amelia Compagni, Patrizio Armeni, Stefano Tasselli
BACKGROUND: Primary care teams (hereafter referred to as primary care units [PCUs]) composed of general practitioners (GPs), nurses, and specialist doctors have recently been established in the Italian context, with the main aim of improving integrated care for chronic diseases. PURPOSES: The aim of the study was to assess whether the increased professional diversity of PCUs has resulted in an improvement in the integrated care of type II diabetes and to identify a potential mechanism mediating this effect...
March 16, 2017: Health Care Management Review
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