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https://www.readbyqxmd.com/read/28737045/pharmacist-s-demand-for-optimal-primary-care-service-delivery-in-a-community-pharmacy-the-optipharm-study
#1
Mark A Munger, Michael Walsh, Jon Godin, Michael Feehan
BACKGROUND: The US population continues to expand providing the need for primary health care services. Community pharmacies integrated with medicine may provide greater access while providing high quality care. OBJECTIVE: To gauge pharmacists' demand for primary health care services delivered through community pharmacies. METHODS: An online survey was administered to determine community pharmacists' preferences for varying primary care services that could be offered in the community pharmacy setting...
July 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28736641/bone-marrow-tolerance-during-postoperative-chemotherapy-in-colorectal-carcinomas
#2
Neil B Newman, Rebecca A Moss, Nell Maloney-Patel, Kristen Donohue, Teresa V Brown, Michael J Nissenblatt, Shou-En Lu, Salma K Jabbour
BACKGROUND: This study seeks to quantify and compare bone marrow tolerance during postoperative chemotherapy therapy between rectal cancer vs. colon cancer patients. During rectal cancer treatment, patients receive neoadjuvant chemoradiation (CRT) irradiation which can exacerbate the hematologic toxicity (HT) via incidental irradiation of the pelvic bone marrow (PBM) during myelosuppressive postoperative chemotherapy. In contrast, colon cancer patients receive the same postoperative myelosuppressive chemotherapy but do not routinely receive preoperative chemoradiation therapy...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28736394/changing-forms-of-hiv-related-stigma-along-the-hiv-care-and-treatment-continuum-in-sub-saharan-africa-a-temporal-analysis
#3
O Bonnington, J Wamoyi, W Ddaaki, D Bukenya, K Ondenge, M Skovdal, J Renju, M Moshabela, A Wringe
OBJECTIVES: Stigma remains pervasive for people living with HIV (PLHIV) in sub-Saharan Africa, undermining care engagement. Using everyday, biographical and epochal temporalities, we explored the manifestation of stigma at different stages of the HIV care continuum in seven health and demographic surveillance sites in Eastern and Southern Africa. METHODS: Between 2015 and 2016, we conducted qualitative in-depth interviews with 264 PLHIV, 54 health providers and 48 family members of people who had died from HIV...
July 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28736148/risk-and-protective-factors-in-the-lives-of-transgender-gender-nonconforming-adolescents
#4
Marla E Eisenberg, Amy L Gower, Barbara J McMorris, G Nicole Rider, Glynis Shea, Eli Coleman
PURPOSE: Research suggests that transgender and gender nonconforming (TGNC) youth may be at greatly increased risk of high-risk health behaviors compared with cisgender youth, but existing studies are limited by convenience samples and small numbers. This study uses a large school-based sample of adolescents to describe the prevalence of TGNC identity, associations with health risk behaviors and protective factors, and differences across birth-assigned sex. METHODS: This study analyzes existing surveillance data provided by 9th and 11th grade students in Minnesota in 2016 (N = 81,885)...
July 20, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28735767/measuring-participation-in-chronic-back-pain-patients-the-5-item-pain-disability-index
#5
Ashley B McKillop, Linda J Carroll, Bruce D Dick, Michele C Battié
BACKGROUND CONTEXT: Of the three broad outcome domains of body functions and structures, activities, and participation (e.g., engaging in valued social roles) outlined in the World Health Organization's (WHO) International Classification of Functioning, Disability and Health (ICF), it has been argued that participation is the most important to individuals, particularly those with chronic health problems. Yet, participation is not commonly measured in back pain research. PURPOSE: The aim of this study was to investigate the construct validity of a modified 5-Item Pain Disability Index (PDI) score as a measure of participation in people with chronic back pain...
July 20, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28732472/genexpert-hiv-1-quant-assay-a-new-tool-for-scale-up-of-viral-load-monitoring-in-the-success-of-art-programme-in-india
#6
Smita Kulkarni, Sushama Jadhav, Priyanka Khopkar, Suvarna Sane, Rajkumar Londhe, Vaishali Chimanpure, Veronica Dhilpe, Manisha Ghate, Rajendra Yelagate, Narayan Panchal, Girish Rahane, Dilip Kadam, Nitin Gaikwad, Bharat Rewari, Raman Gangakhedkar
BACKGROUND: Recent WHO guidelines identify virologic monitoring for diagnosing and confirming ART failure. In view of this, validation and scale up of point of care viral load technologies is essential in resource limited settings. METHODS: A systematic validation of the GeneXpert® HIV-1 Quant assay (a point-of-care technology) in view of scaling up HIV-1 viral load in India to monitor the success of national ART programme was carried out. Two hundred nineteen plasma specimens falling in nine viral load ranges (<40 to >5 L copies/ml) were tested by the Abbott m2000rt Real Time and GeneXpert HIV-1 Quant assays...
July 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28734906/results-from-15years-of-quality-surveillance-for-a-national-indigenous-point-of-care-testing-program-for-diabetes
#7
Mark Shephard, Anne Shephard, Bridgit McAteer, Tamika Regnier, Kristina Barancek
INTRODUCTION: Diabetes is a major health problem for Australia's Aboriginal and Torres Strait Islander peoples. Point-of-care testing for haemoglobin A1c (HbA1c) has been the cornerstone of a long-standing program (QAAMS) to manage glycaemic control in Indigenous people with diabetes and recently, to diagnose diabetes. METHODS: The QAAMS quality management framework includes monthly testing of quality control (QC) and external quality assurance (EQA) samples. Key performance indicators of quality include imprecision (coefficient of variation [CV%]) and percentage acceptable results...
July 19, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28734861/low-food-allergy-prevalence-despite-delayed-introduction-of-allergenic-foods-data-from-the-gusto-cohort
#8
Elizabeth Huiwen Tham, Bee Wah Lee, Yiong Huak Chan, Evelyn Xiu Ling Loo, Jia Ying Toh, Anne Goh, Oon Hoe Teoh, Fabian Yap, Kok Hian Tan, Keith M Godfrey, Mary Foong Fong Chong, Hugo P S Van Bever, Yap Seng Chong, Lynette Pei-Chi Shek
BACKGROUND: There is mounting evidence that early introduction of allergenic food decreases the risk of food allergy development, especially in high-risk infants with eczema. However, there is a lack of data to suggest whether this association holds true in Asian populations. OBJECTIVE: To investigate the relationship between the timing of introduction of allergenic foods and food allergy outcomes in infants in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study...
July 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28734103/levels-of-wound-calprotectin-and-other-inflammatory-biomarkers-aid-in-deciding-which-patients-with-a-diabetic-foot-ulcer-need-antibiotic-therapy-induce-study
#9
J R Ingram, S Cawley, E Coulman, C Gregory, E Thomas-Jones, T Pickles, R Cannings-John, N A Francis, K Harding, K Hood, V Piguet
AIMS: Deciding if a diabetic foot ulcer is infected in a community setting is challenging without validated point-of-care tests. Four inflammatory biomarkers were investigated to develop a composite algorithm for mildly infected diabetic foot ulcers: venous white cell count, C-reactive protein (CRP) and procalcitonin, and a novel wound exudate calprotectin assay. Calprotectin is a marker of neutrophilic inflammation. METHODS: In a prospective study, people with uninfected or mildly infected diabetic foot ulcers who had not received oral antibiotics in the preceding 2 weeks were recruited from community podiatry clinics for measurement of inflammatory biomarkers...
July 22, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28732085/point-of-care-screening-for-hepatitis-b-virus-infection-in-pregnant-women-at-an-antenatal-clinic-a-south-african-experience
#10
Nafiisah Chotun, Wolfgang Preiser, Christoffel Johannes van Rensburg, Pedro Fernandez, Gerhard Barnard Theron, Dieter Glebe, Monique Ingrid Andersson
BACKGROUND & AIMS: Elimination of HIV and syphilis mother-to-child transmission (MTCT) has received much attention but little consideration has been given to the possibility of elimination of HBV MTCT. In sub-Saharan Africa, HBV vertical transmission continues to be reported and it remains an important public health problem. This study aimed to assess the feasibility of screening pregnant women for HBV using a point-of-care (POC) test and implementing interventions to prevent HBV MTCT...
2017: PloS One
https://www.readbyqxmd.com/read/28729228/tangled-history-of-the-european-uses-of-sphagnum-moss-and-sphagnol
#11
REVIEW
Jacek Drobnik, Adam Stebel
ETHNOPHARMACOLOGICAL RELEVANCE: Sphagnum mosses and peat could have been utilized as wound dressings for centuries, however reliable data on this subject are ambiguous; sometimes even no distinction between peat moss (Sphagnum spp.) and peat is made or these terms become confused. The first scientific account on surgical use of peat comes from 1882: a peat digger who successfully, by himself and in the way unknown to the then medicine, cured an open fracture of his forearm with peat. The peat, and very soon the peat moss itself (which is the major constituent of peat) drew attention of the 19(th)-century surgeons...
July 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28729164/antenatal-antipsychotic-exposure-induces-multigenerational-and-gender-specific-programming-of-adiposity-and-glucose-tolerance-in-adult-mouse-offspring
#12
E Courty, P Gobalakichenane, M Garcia, A Muscat, C Kazakian, T Ledent, M Moldes, B Blondeau, D Mitanchez, M Buyse, B Fève
Second-generation antipsychotics (SGAs) are well known for their metabolic side effects in humans, including obesity and diabetes. These compounds are maintained during pregnancy to prevent the relapse of psychoses, but they readily diffuse across the placenta to the fetus, as documented with the widely-prescribed drug olanzapine (OLZ). However, observational studies have provided conflicting results on the potential impact of SGAs on fetal growth and body weight, and their effects on metabolic regulation in the offspring...
July 17, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28729007/the-feasibility-of-point-of-care-ankle-ultrasound-examination-in-patients-with-recurrent-ankle-sprain-and-chronic-ankle-instability-comparison-with-magnetic-resonance-imaging
#13
Sun Hwa Lee, Seong Jong Yun
OBJECTIVE: To evaluate the feasibility of point-of-care ankle ultrasound compared with magnetic resonance imaging (MRI) for diagnosing major ligaments and Achilles tendon injuries in patients with recurrent ankle sprain and chronic instability, and to evaluate inter-observer reliability between an emergency physician and a musculoskeletal radiology fellow. MATERIAL AND METHODS: A prospective cross-sectional study was conducted in an emergency department. Patients with recurrent ankle sprain and chronic instability were recruited...
July 13, 2017: Injury
https://www.readbyqxmd.com/read/28728602/robot-assisted-training-for-the-upper-limb-after-stroke-ratuls-study-protocol-for-a-randomised-controlled-trial
#14
Helen Rodgers, Lisa Shaw, Helen Bosomworth, Lydia Aird, Natasha Alvarado, Sreeman Andole, David L Cohen, Jesse Dawson, Janet Eyre, Tracy Finch, Gary A Ford, Jennifer Hislop, Steven Hogg, Denise Howel, Niall Hughes, Hermano Igo Krebs, Christopher Price, Lynn Rochester, Elaine Stamp, Laura Ternent, Duncan Turner, Luke Vale, Elizabeth Warburton, Frederike van Wijck, Scott Wilkes
BACKGROUND: Loss of arm function is a common and distressing consequence of stroke. We describe the protocol for a pragmatic, multicentre randomised controlled trial to determine whether robot-assisted training improves upper limb function following stroke. METHODS/DESIGN: Study design: a pragmatic, three-arm, multicentre randomised controlled trial, economic analysis and process evaluation. SETTING: NHS stroke services. PARTICIPANTS: adults with acute or chronic first-ever stroke (1 week to 5 years post stroke) causing moderate to severe upper limb functional limitation...
July 20, 2017: Trials
https://www.readbyqxmd.com/read/28728008/pen-on-paper-strategy-for-point-of-care-testing-rapid-prototyping-of-fully-written-microfluidic-biosensor
#15
Zedong Li, Fei Li, Yue Xing, Zhi Liu, Minli You, Yingchun Li, Ting Wen, Zhiguo Qu, Xiao Ling Li, Feng Xu
Paper-based microfluidic biosensors have recently attracted increasing attentions in point-of-care testing (POCT) territories benefiting from their affordable, accessible and eco-friendly features, where technologies for fabricating such biosensors are preferred to be equipment free, easy-to-operate and capable of rapid prototyping. In this work, we developed a pen-on-paper (PoP) strategy based on two custom-made pens, i.e., a wax pen and a conductive-ink pen, to fully write paper-based microfluidic biosensors through directly writing both microfluidic channels and electrodes...
July 1, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28728007/direct-immune-detection-of-cortisol-by-chemiresistor-graphene-oxide-sensor
#16
Yo-Han Kim, Kyungmin Lee, Hunsang Jung, Hee Kyung Kang, Jihoon Jo, In-Kyu Park, Hyun Ho Lee
In this study, a biosensor to detect a stress biomarker of cortisol using cortisol monoclonal antibody (c-Mab) covalently immobilized on reduced graphene oxide (rGO) channel as electrical sensing element was demonstrated. Highly specific immune-recognition between the c-Mab and the cortisol was identified and characterized on a basis of resistance change at the rGO channel based chemiresistor sensor achieving the limit of detection of 10pg/mL (27.6 pM). In addition, cortisol concentrations of real human salivary sample and buffer solution of rat adrenal gland acute slices, which could secret the cortisol induced by adrenocorticotropic hormone (ACTH), were directly measured by the chemiresistor corresponding to the specific sensing of the cortisol...
July 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28727771/randomized-controlled-trial-on-the-effects-of-a-supervised-high-intensity-exercise-program-in-patients-with-a-hematologic-malignancy-treated-with-autologous-stem-cell-transplantation-results-from-the-exist-study
#17
Saskia Persoon, Mai J M ChinAPaw, Laurien M Buffart, Roberto D K Liu, Pierre Wijermans, Harry R Koene, Monique C Minnema, Pieternella J Lugtenburg, Erik W A Marijt, Johannes Brug, Frans Nollet, Marie José Kersten
BACKGROUND: This single blind, multicenter randomized controlled trial aimed to evaluate the effectiveness of a supervised high intensity exercise program on physical fitness and fatigue in patients with multiple myeloma or lymphoma recently treated with autologous stem cell transplantation. METHODS: 109 patients were randomly assigned to the 18-week exercise intervention or the usual care control group. The primary outcomes included physical fitness (VO2peak and Wpeak determined using a cardiopulmonary exercise test; grip strength and the 30s chair stand test) and fatigue (Multidimensional Fatigue Inventory) and were assessed prior to randomization and after completion of the intervention or at similar time points for the control group...
2017: PloS One
https://www.readbyqxmd.com/read/28727755/no-abatement-of-steroid-injections-for-tennis-elbow-in-australian-general-practice-a-15-year-observational-study-with-random-general-practitioner-sampling
#18
Bill Vicenzino, Helena Britt, Allan J Pollack, Michelle Hall, Kim L Bennell, David J Hunter
OBJECTIVE: Evaluate general practitioner (GP) management of tennis elbow (TE) in Australia. METHODS: Data about the management of TE by GPs from 2000 to 2015 were extracted from the Bettering the Evaluation of Care of Health program database. Patient and GP characteristics and encounter management data were classified by the International Classification of Primary Care, version 2, and reported using descriptive statistics with point estimates and 95% confidence intervals...
2017: PloS One
https://www.readbyqxmd.com/read/28727183/a-randomised-controlled-trial-on-a-nurse-led-smartphone-based-self-management-programme-for-patients-with-poorly-controlled-type-2-diabetes-a-study-protocol
#19
Wenru Wang, Betsy Seah, Ying Jiang, Violeta Lopez, Cherry Tan, Suan Tee Lim, Hongliang Ren, Yin Hao Khoo
AIM: To develop and compare a nurse-led smartphone-based self-management programme with an existing nurse-led diabetes service on health-related outcomes for patients with poorly controlled type 2 diabetes in Singapore. BACKGROUND: Over the past decades, Asia has emerged as the 'diabetes epicentre' in the world due to rapid economic development, urbanisation and nutrition transition. There is an urgent need to develop more effective care management strategies in response to this rising diabetes epidemic...
July 20, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28725261/health-risk-behavior-among-chronically-ill-adolescents-a-systematic-review-of-assessment-tools
#20
REVIEW
Derrick Ssewanyana, Moses Kachama Nyongesa, Anneloes van Baar, Charles R Newton, Amina Abubakar
BACKGROUND: Adolescents living with chronic illnesses engage in health risk behaviors (HRB) which pose challenges for optimizing care and management of their ill health. Frequent monitoring of HRB is recommended, however little is known about which are the most useful tools to detect HRB among chronically ill adolescents. AIMS: This systematic review was conducted to address important knowledge gaps on the assessment of HRB among chronically ill adolescents. Its specific aims were to: identify HRB assessment tools, the geographical location of the studies, their means of administration, the psychometric properties of the tools and the commonest forms of HRB assessed among adolescents living with chronic illnesses globally...
2017: Child and Adolescent Psychiatry and Mental Health
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