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https://www.readbyqxmd.com/read/28926400/hepatitis-b-hepatitis-c-and-mortality-among-hiv-positive-individuals
#1
Alicia C Thornton, Sophie Jose, Sanjay Bhagani, David Chadwick, David Dunn, Richard Gilson, Janice Main, Mark Nelson, Alison Rodger, Chris Taylor, Elaney Youssef, Clifford Leen, Mark Gompels, Stephen Kegg, Achim Schwenk, Caroline Sabin
OBJECTIVES: To compare rates of all-cause, liver-related and AIDS-related mortality among individuals who are HIV mono-infected with those co-infected with HIV and hepatitis B (HBV) and/or hepatitis C (HCV) viruses. DESIGN: An ongoing observational cohort study collating routinely collected clinical data on HIV-positive individuals attending for care at HIV treatment centres throughout the UK. METHODS: Individuals were included if they had been seen for care from 2004 onwards and had tested for HBV and HCV...
September 18, 2017: AIDS
https://www.readbyqxmd.com/read/28924431/occult-hepatitis-infection-in-transfusion-medicine-screening-policy-and-assessment-of-current-use-of-anti-hbc-testing
#2
REVIEW
Antonella Esposito, Chiara Sabia, Carmela Iannone, Giovanni F Nicoletti, Linda Sommese, Claudio Napoli
HBV still represents a global risk factor in transfusion medicine. The residual risk of HBV is not limited to pre-seroconversion window period but it extends to donors with occult HBV infection (OBI) characterized by the presence of HBV DNA in liver and by the absence of the virus surface antigen. Each country developed an appropriate blood screening policy according to local HBV prevalence, yields of infectious units per different screening methods and cost-effectiveness. We underline the need of maintaining a high level of attention for OBI carrier identification in all blood banks worldwide where the screening procedures are generally based on a combination of both serological markers and nucleic acid amplification test...
August 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28923315/development-of-a-digital-droplet-pcr-assay-to-measure-hbv-dna-in-patients-receiving-long-term-tdf-treatment
#3
Yang Liu, Andrea L Cathcart, William E Delaney, Kathryn M Kitrinos
The COBAS TaqMan assay has a lower limit of quantification (LLOQ) of 169 HBV copies/mL and a lower limit of detection (LLOD) of 58 copies/mL. HBV DNA below the TaqMan LLOQ is classified as target not detected (TND) (<58 copies/mL) or target detected (TD) (between 58 to 169 copies/mL). Here we have developed a more sensitive digital droplet PCR (ddPCR) assay to evaluate the impact of long-term tenofovir disoproxil fumarate (TDF) treatment in patients that did or did not achieve HBsAg seroconversion. A ddPCR assay was developed to detect HBV DNA to 8 copies/mL...
September 15, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28921677/clinical-profile-of-hepatitis-c-virus-infection-in-a-developing-country-india
#4
Ramit Mahajan, Vandana Midha, Omesh Goyal, Varun Mehta, Vikram Narang, Kirandeep Kaur, Arshdeep Singh, Dharmatma Singh, Rishu Bhanot, Ajit Sood
BACKGROUND: The epidemiology and clinical profile of hepatitis C virus (HCV) varies worldwide and data from developing countries is sparse. AIMS: To study the clinical profile of HCV infection in a developing country in South East Asia (India). METHODS: This observational study assessed patient demographics, viral characteristics, risk factors for virus acquisition and disease characteristics in HCV patients diagnosed between January 2004 and December 2015...
September 18, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28919545/mechanisms-behind-tb-hbv-and-hiv-chronic-infections
#5
David Durantel, Inca Kusters, Jacques Louis, Nicolas Manel, Tom H M Ottenhoff, Valentina Picot, Mitra Saaadatian-Elahi
Immune evasion is critical for pathogens to maintain their presence within hosts, giving rise to chronic infections. Here, we examine the immune evasion strategies employed by three pathogens with high medical burden, namely, tuberculosis, HIV and HBV. Establishment of chronic infection by these pathogens is a multi-step process that involves an interplay between restriction factor, innate immunity and adaptive immunity. Engagement of these host defences is intimately linked with specific steps within the pathogen replication cycles...
September 13, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28919469/assignment-of-the-absolute-configuration-of-hepatoprotective-highly-oxygenated-triterpenoids-using-x-ray-ecd-nmr-j-based-configurational-analysis-and-hsqc-overlay-experiments
#6
Xiaojuan Wang, Jiabao Liu, Pankaj Pandey, Jiabao Chen, Frank R Fronczek, Stuart Parnham, Xinzhu Qi, Robert J Doerksen, Daneel Ferreira, Hua Sun, Shuai Li, Mark T Hamann
BACKGROUND: The plants of the genus Kadsura are widely distributed in China, South Korea, and Japan. Their roots and stems are traditionally used to treat blood diseases and pain. The main bioactive constituents of Kadsura longipedunculata comprise highly oxygenated triterpenoids. Schiartane-type nortriterpenoids showed anti-HIV, anti-HBV, and cytotoxic bioactivities. For such compounds, the absolute configuration influences the bioactivities, and hence its unambiguous determination is essential...
September 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28918011/nucleic-acid-polymers-with-accelerated-plasma-and-tissue-clearance-for-chronic-hepatitis-b-therapy
#7
Ingo Roehl, Stephan Seiffert, Celia Brikh, Jonathan Quinet, Catherine Jamard, Nadine Dorfler, Jennifer A Lockridge, Lucyna Cova, Andrew Vaillant
REP 2139 is a nucleic acid polymer (NAP) currently under clinical development for chronic hepatitis B (HBV) therapy. This preclinical study investigated different REP 2139 analogs that would display reduced accumulation in the serum and tissues, while retaining an antiviral effect against HBV infection. REP 2139 analogs were evaluated in human plasma, CD-1 mice, cynomolgus monkeys, and Pekin ducks. Discrete ribose transformation to 2'OH in selected riboadenosines resulted in a slow degradation in acidified human plasma that plateaued after 48 hr...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28915824/fucoidan-from-fucus-vesiculosus-suppresses-hepatitis-b-virus-replication-by-enhancing-extracellular-signal-regulated-kinase-activation
#8
Huifang Li, Junru Li, Yuan Tang, Lin Lin, Zhanglian Xie, Jia Zhou, Liyun Zhang, Xiaoyong Zhang, Xiaoshan Zhao, Zhengliang Chen, Daming Zuo
BACKGROUND: Hepatitis B virus (HBV) infection is a serious public health problem leading to cirrhosis and hepatocellular carcinoma. As the clinical utility of current therapies is limited, the development of new therapeutic approaches for the prevention and treatment of HBV infection is imperative. Fucoidan is a natural sulfated polysaccharide that extracted from different species of brown seaweed, which was reported to exhibit various bioactivities. However, it remains unclear whether fucoidan influences HBV replication or not...
September 16, 2017: Virology Journal
https://www.readbyqxmd.com/read/28915572/down-regulation-of-ntcp-expression-by-cyclin-d1-in-hepatitis-b-virus-related-hepatocellular-carcinoma-has-clinical-significance
#9
Jingting Kang, Jie Wang, Jin Cheng, Zhiliang Cao, Ran Chen, Huiyu Li, Shuang Liu, Xiangmei Chen, Jianhua Sui, Fengmin Lu
The sodium-dependent taurocholate cotransporter polypeptide (NTCP) has been identified as a liver specific functional receptor for the hepatitis B virus (HBV). Previous studies indicated that the expression of NTCP may be associated with the proliferation status of hepatocytes. However, the involvement of NTCP in hepatocellular carcinoma (HCC) cells proliferation remains unclear. In this study, we confirmed that NTCP was down-regulated in HCC tumor tissues compared with that in the adjacent non-tumor tissues (P < 0...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914957/hepatitis-b-virus-core-related-antigen-levels-predict-progression-to-liver-cirrhosis-in-hepatitis-b-carriers
#10
Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Natsuko Kobayashi, Tomoyuki Akita, Junko Tanaka
BACKGROUND AND AIM: Several hepatitis B virus (HBV) markers have been identified as risk factors for progression to liver cirrhosis in patients with chronic HBV infection. We clarified the predictive impact of HBV markers on progression to cirrhosis in HBV carriers. METHODS: A total of 529 hepatitis B e antigen seroconverters with FIB-4 index ≤3.6 not on nucleos(t)ide analogue therapy were included. We performed univariate and multivariate analysis of associations between HBV markers and progression to cirrhosis...
September 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28913356/expression-profiling-of-cellular-microrna-in-asymptomatic-hbsag-carriers-and-chronic-hepatitis-b-patients
#11
Xianliang Hou, Yan Liang, Jianing Chen, Yingfeng Wei, Ping Zeng, Lin Wang, Chong Lu, Hongyan Diao
BACKGROUND: MicroRNAs (miRNAs) may serve as potential molecular markers to predict liver injury resulting from chronic hepatitis B (CHB). In the present study, we want to study the expression profile and clinical significance of miRNAs at different stages of CHB virus infection. METHODS: Using miRNA microarray, we investigated the global expression profiles of cellular miRNA in asymptomatic hepatitis B antigen carriers (ASCs) and CHB patients, compared with healthy controls (HCs)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28912718/technical-improvement-and-application-of-hydrodynamic-gene-delivery-in-study-of-liver-diseases
#12
REVIEW
Mei Huang, Rui Sun, Qiang Huang, Zhigang Tian
Development of an safe and efficient in vivo gene delivery method is indispensable for molecular biology research and the progress in the following gene therapy. Over the past few years, hydrodynamic gene delivery (HGD) with naked DNA has drawn increasing interest in both research and potential clinic applications due to its high efficiency and low risk in triggering immune responses and carcinogenesis in comparison to viral vectors. This method, involving intravenous injection (i.v.) of massive DNA in a short duration, gives a transient but high in vivo gene expression especially in the liver of small animals...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28912447/development-and-validation-of-a-nomogram-for-predicting-survival-in-patients-with-advanced-pancreatic-ductal-adenocarcinoma
#13
Qing-Long Deng, Shu Dong, Lei Wang, Chen-Yue Zhang, Hai-Feng Ying, Zhao-Shen Li, Xiao-Heng Shen, Yuan-Bao Guo, Zhi-Qiang Meng, Jin-Ming Yu, Qi-Wen Chen
This study aimed to develop and validate an effective prognostic nomogram for advanced PDAC patients. We conducted a prospective multicenter cohort study involving 1,526 advanced PDAC patients from three participating hospitals in China between January 1, 2004 and December 31, 2013. Two thirds of the patients were randomly assigned to the training set (n = 1,017), and one third were assigned to the validation set (n = 509). Multivariate cox regression analysis was performed to identify significant prognostic factors for overall survival to develop the nomogram...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910947/-meta-analysis-on-hbsag-positive-rate-among-general-populations-aged-1-59-years-2007-2016-china
#14
W L Zhang, Z H Ji, T Fu, L Zhang, H X Su, Y P Yan
Objective: To perform a Meta-analysis on hepatitis B surface antigen (HBsAg)-positive rates among general Chinese population aged 1-59 years. Methods: We systemically reviewed the related data (January 2007 to August 2016) published from Chinese National Knowledge Infrastructure (CNKI), VIP, and PubMed. We also assessed the HBsAg-positive rates among general Chinese populations aged 1-59 years, using a random effects regression model with the comprehensive Meta-analysis software 2.2. Results: A total of 46 papers were finally included, with a total sample size of 625 053 individuals...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28910924/-a-survey-of-hiv-hbv-and-hcv-infections-in-children-aged-1-13-years-in-yi-ethnic-area-sichuan-province
#15
Y Yang, Y B Zhou, W T Cheng, X Pan, X X Song, Q W Jiang
Objective: To investigate the prevalence of HIV, HBV and HCV infections in children aged 1-13 years in Yi ethnic area in Sichuan province. Methods: A cross-sectional study was conducted in the form of field survey in four townships selected from Yi ethnic area of Sichuan during 2014-2015. Participants were children aged 1-13 years by sample size of 900 and were screened for HIV antibody, HBV surface antigen and HCV antibody, and laboratory comfirmation was conducted. The area, age, gender and ethnic group specific infection rates were compared by using Fisher's exact test, and multiple comparisons were corrected by using Bonferroni correction...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28910921/-effectiveness-of-rapid-hepatitis-b-vaccination-with-different-vaccine-dosages-and-types-in-adults
#16
L Nie, X H Pang, Z Zhang, J X Ma, X Y Liu, Q Qiu, Y Liang, Q Li, W Zhang
Objective: To evaluate the effectiveness of rapid hepatitis B vaccination with different vaccine dosages and types in adults. Methods: Adults who were aged ≥20 years, negative in the detections of 5 HBV serum markers or only anti-HBc positive were selected from Chaoyang district of Beijing. They were divided into 4 community-based specific groups and given three doses of 10 μg HepB-SCY vaccine, 20 μg HepB-SCY vaccine, 20 μg HepB-CHO vaccine and 10 μg HepB-HPY vaccine respectively at month 0, 1, and 2...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28910308/pulmonary-hypertension-among-5-to-18-year-old-children-with-sickle-cell-anaemia-in-nigeria
#17
Ogochukwu J Sokunbi, Ekanem N Ekure, Edamisan O Temiye, Roosevelt Anyanwu, Christy A N Okoromah
BACKGROUND: Pulmonary hypertension (PHT) is a significant cause of mortality in patients with sickle cell disease (SCD). Few studies on PHT in SCD have been carried out in children. This study aimed to estimate the prevalence of PHT in children with sickle cell anaemia (SCA) and determine its clinical and laboratory correlates. METHODS: In this cross sectional study, evaluation involved obtaining bio-data, history and physical examination findings in 175 SCA subjects with haemoglobin genotype SS aged 5 to 18 years and 175 age and sex matched controls with haemoglobin genotype AA...
2017: PloS One
https://www.readbyqxmd.com/read/28906278/hepatitis-b-reactivation-in-a-long-term-nonprogressor-due-to-nivolumab-therapy
#18
Adam C Lake
: Hepatitis B virus (HBV) reactivation has been documented in association with multiple immunotherapy regimens . These reactivations can be life-threatening and result in fulminant hepatic failure. There are currently no reports of HBV reactivation on nivolumab treatment. This is a case of a patient with known HIV infection and previous HBV workup that revealed him to be anti-hepatitis B core antibody positive, hepatitis B surface antigen negative, and HBV DNA negative. He experienced a HBV reactivation while on therapy with nivolumab for stage IIIa poorly differentiated carcinoma of the lung, which was a recurrence from a prior surgically resected stage Ia well differentiated adenocarcinoma of the lung...
September 24, 2017: AIDS
https://www.readbyqxmd.com/read/28905444/response-to-hepatitis-b-vaccination-in-patients-with-liver-cirrhosis
#19
REVIEW
Ioanna Aggeletopoulou, Panagiota Davoulou, Christos Konstantakis, Konstantinos Thomopoulos, Christos Triantos
Hepatitis B vaccination is strongly recommended for all infants and children but also for adults who are at risk of HBV infection. Attempts to immunize patients with liver cirrhosis have been proven relatively ineffective, and several strategies have already been used to improve the immune response in this group. The primary aim of this review is to examine, discuss, and summarize the immunogenicity of hepatitis B vaccination in patients with liver cirrhosis. MEDLINE search identified 11 studies (n = 961)...
September 14, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/28905194/is-there-an-association-between-pemphigus-and-hepatitis-viruses-a-population-based-large-scale-study
#20
Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Arnon D Cohen
The association between pemphigus and hepatitis viruses has not been investigated sufficiently and remains unclear. Our objective was to assess the association between pemphigus and chronic hepatitis B (HBV) and hepatitis C (HCV) infections using a large-scale real-life computerized database. This study was conducted as a cross-sectional study utilizing the database of Clalit Health Services. The proportion of chronic HBV and HCV infections was compared between patients diagnosed with pemphigus and age-, sex-, and ethnicity-matched controls...
September 13, 2017: Immunologic Research
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