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https://www.readbyqxmd.com/read/27933716/risks-and-treatment-strategies-for-de-novo-hepatitis-b-virus-infection-from-anti-hbc-positive-donors-in-pediatric-living-donor-liver-transplantation
#1
Chong Dong, Wei Gao, Nan Ma, Chao Sun, Wei-Ping Zheng, Kai Wang, Zhong-Yang Shen
The aim of this study was to analyze the incidence and risk factors of de novo HBV infection in pediatric patients receiving living donor liver transplants (LDLT) from HBcAb-positive donors, and to explore its treatment strategies. The data of 101 pediatric recipients receiving LDLT in Tianjin First Central Hospital between September 2006 and December 2012 were retrospectively analyzed. The HBV markers were regularly tested before and after the surgery, including HBsAb, HBsAg, HBeAg, HBeAb, and HBcAb. The median follow-up period was 25...
December 9, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27933509/effect-of-shuanghu-qinggan-granule-and-yigan-yiqi-jieyu-granule-plus-lamivudine-on-chronic-hepatitis-b-patients-a-randomized-double-blind-placebo-controlled-trial
#2
Yong-An Ye, De-Lu Tian, Jian Jiang, Jun Li, Jian-Jie Chen, Zhi-Hong Li, Wei-Guo Ma, Yi-Ming Zhao, Rong-Bing Wang, Shi-Zhong Yang, Feng-Zhen Shao, Guang Ji, Da-Qiao Zhou, Tie-Jun Liu, Dong-Sheng Cheng, Wei Zhang, Ke-Wei Sun, Yu-Fen Wang, Le-Quan Min, Xiao-Ke Li
OBJECTIVE: To observe the clinical efficacy and safety of Shuanghu Qinggan Granule ( , SQG) plus Yigan Yiqi Jieyu Granule (, YYJG) combined with lamivudine (LAM) on chronic hepatitis B (CHB) patients. METHODS: The study was a multicenter, randomized, double-blinded and parallel controlled trial. A total of 320 patients were randomly allocated into 2 groups equally: 160 patients (treatment group) were given SQG and YYJG combined with LAM; and 160 patients (control group) were given LAM plus Chinese herb placebo, respectively...
December 8, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27931582/liver-transplantation-for-hepatitis-b-in-early-adulthood-analysis-of-the-united-network-for-organ-sharing-database
#3
G Rifai, A Anani, I A Hanouneh, B Mohamad, A Matloob, R Lopez, N N Zein, N Alkhouri
BACKGROUND: Chronic hepatitis B virus (HBV) infection has a mild course in most children that may delay initiation of treatment even when indicated. Unfortunately, a small number of cases can progress rapidly to cirrhosis, which may require liver transplantation (LT) in early adulthood. The aim of this study was to assess the characteristics of HBV-positive young adults who received LT and to evaluate post-transplant outcomes including patient and graft survival and differences between pre- and post-implementation of Model for End-stage Liver Disease (MELD) prioritization...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27930871/hepatitis-b-virus-infection-status-is-more-prevalent-in-patients-with-type-2-diabetes
#4
Jun Lu, Xuhong Hou, Hong Tu, Zhenghao Tang, Yongbing Xiang, Yuqian Bao, Jianren Gu, Weiping Jia
AIMS/INTRODUCTION: It has not been reported whether chronic hepatitis B virus (HBV) infection (CHB) is associated with a specific type of diabetes. We sought to investigate the prevalence of CHB status in different diabetes subtypes among Chinese population MATERIALS AND METHODS: This is a cross-sectional study. 381 cases with adult-onset autoimmune diabetes,1365 patients with type 2 diabetes, and 1365 non-diabetic controls were recruited from Jun 2005 to Feb 2014.The exclusion criteria included: (1) HCV-antibody positive, (2) hepatic cirrhosis, (3) malignant neoplasm and severe renal dysfunction (serum creatinine > 450 umol/L)...
December 8, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27930595/hepatitis-b-viremia-in-completely-immunized-individuals-negative-for-anti-hepatitis-b-core-antibody
#5
Ming-Wei Lai, Tzou-Yien Lin, Kung-Hao Liang, Wey-Ran Lin, Chau-Ting Yeh
The presence of anti-hepatitis B virus (HBV) core antibody (anti-HBc) is considered a sensitive lifetime marker of HBV infection. Here, we examined this dogma by investigating the prevalence of hepatitis B viremia in anti-HBc negative complete vaccines in Taiwan.A total of 795 participants (1.7-20.0 years old) had completed HBV vaccination in infancy and were anti-HBc negative. Serum samples were available for 460 individuals with isolated anti-HBV surface antibodies (anti-HBs) (HBsAg-negative and anti-HBc negative) and for 245 individuals who tested negative for all 3 markers (triple seronegative)...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930572/acute-onset-chronic-inflammatory-demyelinating-polyneuropathy-in-hantavirus-and-hepatitis-b-virus-coinfection-a-case-report
#6
Jong Youb Lim, Young-Ho Lim, Eun-Hi Choi
INTRODUCTION: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired autoimmune disorder with progressive weakness. Acute-onset CIDP resembles Guillain-Barre syndrome (GBS), a rapidly progressive disorder, and follows a chronic course. To our knowledge, no case of acute-onset CIDP in hantavirus and hepatitis B virus (HBV) coinfection has been reported previously. CLINICAL FINDINGS: We report a case of acute-onset CIDP that was initially diagnosed as GBS...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27928086/barriers-to-linkage-to-care-for-hepatitis-b-virus-infection-a-qualitative-analysis-in-burkina-faso-west-africa
#7
Tamara Giles-Vernick, Fabienne Hejoaka, Armande Sanou, Yusuke Shimakawa, Issiaka Bamba, Abdoulaye Traoré
Hepatitis B virus (HBV) infection is a critical global health problem. The World Health Organization (WHO) has recently developed a global elimination strategy for HBV infection. Increasing access to screening, liver assessment, and antiviral treatment are crucial steps in achieving this goal. Little is known, however, about obstacles to linkage to care in low- and middle-income countries. Using a grounded theory approach, this qualitative study sought to characterize the diagnostic itineraries of people with chronic HBV infection in Burkina Faso, a west African country with high HBV prevalence, to identify barriers to linkage from screening to specialist care with hepatic assessment (alanine transaminase and hepatitis B e antigen or HBV DNA)...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27927202/positive-association-between-serum-apolipoprotein-m-levels-and-hepatitis-b-virus-dna-load-in-hbeag-negative-chronic-hepatitis-b
#8
Ting Shen, Wei Min Wu, Wen Han Du, Lin Wang, La Gu He, Li Tan, ZeYou Wang, Ruohong Chen, Min Hu, Ya Ping Ren
BACKGROUND: Hepatitis virus B (HBV) has infected millions of people worldwide. Notably, such infections can be associated with hepatic complications. Levels of apolipoprotein M (apoM), a component of high-density lipoprotein (HDL), are known to be significantly elevated in patients with chronic hepatitis B (CHB). The aim of this study was to investigate the relationship between HBV DNA load in serum and serum apoM levels in patients with CHB. METHODS: A total of 73 HBeAg-negative CHB patients, 50 HBeAg-positive CHB patients, and 79 non-CHB controls were included in the study cohort...
December 7, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27925503/persistence-of-protective-anti-hbs-antibody-levels-and-anamnestic-response-to-hbv-booster-vaccination-a-cross-sectional-study-among-healthcare-students-20%C3%A2-years-following-the-universal-immunization-campaign-in-italy
#9
Guglielmo Dini, Alessandra Toletone, Ilaria Barberis, Nicoletta Debarbieri, Emanuela Massa, Chiara Paganino, Francesca Bersi, Alfredo Montecucco, Cristiano Alicino, Paolo Durando
Vaccination against Hepatitis B Virus (HBV) became mandatory in Italy for all newborns and twelve years-old individuals in the 1991. The immunogenicity of HBV vaccine and the effectiveness of the universal immunization strategy have been widely demonstrated. However the need to assess the antibody concentrations above the well known serological correlate of protection for HBV infection (≥ 10 mIU/mL), established in individuals immunized with a three doses vaccination course, is still recommended in subjects exposed to occupational risks in different settings, particularly the healthcare services...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27925409/more-improvement-than-progression-of-liver-fibrosis-following-antiretroviral-therapy-in-a-longitudinal-cohort-of-hiv-infected-patients-with-or-without-hbv-and-hcv-co-infections
#10
Yingying Ding, Song Duan, Runhua Ye, Yuecheng Yang, Shitang Yao, Jibao Wang, Dongdong Cao, Xing Liu, Lin Lu, Manhong Jia, Zunyou Wu, Na He
We examined the effect of combination antiretroviral therapy (cART) on liver fibrosis among HIV-infected patients with or without Hepatitis B (HBV) or C virus (HCV) co-infection. This was a retrospective cohort study of HIV-infected patients receiving cART during 2004-2016. Liver fibrosis was assessed using Fibrosis-4 (FIB-4) score with 3 classifications: Class 1, < 1.45; Class 2, 1.45-3.25; Class 3, > 3.25. Of 3,900 participants, 68.6% were HIV mono-infected, 5.3% were HIV/HBV co-infected, 23.8% were HIV/HCV co-infected and 2...
December 7, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27925346/hepatitis-c-infection-and-other-drug-related-harms-among-inpatients-who-injected-drugs-in-turkey
#11
Arash Alaei, Kamiar Alaei, Katherine Waye, Melissa Tracy, Marine Nalbandyan, Elif Mutlu, Mustafa Kemal Cetin
Hepatitis C Virus (HCV) is easily spread among those who share drug injection equipment. Due to the ease of contraction and growing prevalence of HCV in Eastern Europe, the aims of this study focused on describing risky injection practices as well as the prevalence of HCV, HIV, and Hepatitis B Virus (HBV) among people who inject drugs (PWID) that were admitted to public and private drug treatment centers in Turkey from 2012 to 2013. Other aims included identifying correlates of needle sharing and HCV infection...
December 7, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27925189/hbx-drives-alpha-fetoprotein-expression-to-promote-initiation-of-liver-cancer-stem-cells-through-activating-pi3k-akt-signal-pathway
#12
Mingyue Zhu, Wei Li, Yan Lu, Xu Dong, Bo Lin, Yi Chen, Xueer Zhang, Junli Guo, Mengsen Li
Hepatitis B virus (HBV)-X protein (HBx) plays critical role in inducing the malignant transformation of liver cells. Alpha fetoprotein (AFP) expression is closely related to hepatocarcinogenesis. We report that Oct4, Klf4, Sox2 and c-myc expression positively associated with AFP(+)/HBV(+) hepatocellular carcinoma(HCC) tissues, and the expression of the stemness markers CD44, CD133 and EpCAM was significantly higher in AFP(+)/HBV(+) HCC tissues compared to normal liver tissues or AFP(-)/HBV(-) HCC tissues. AFP expression turned on prior to expression of Oct4, Klf4, Sox2 and c-myc, and the stemness markers CD44, CD133 and EpCAM in the normal human liver L-02 cell line or CHL cell lines upon transfection with MCV-HBx vectors...
December 7, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27924779/hepatic-safety-of-maraviroc-in-patients-with-hiv-1-and-hepatitis-c-and-or-b-virus-144-week-results-from-a-randomized-placebo-controlled-trial
#13
Juergen K Rockstroh, Frank Plonski, Meena Bansal, Gerd Fätkenheuer, Catherine B Small, David M Asmuth, Gilles Pialoux, Rebecca Zhang-Roper, Ronnie Wang, Juan A Pineda, Jayvant Heera
BACKGROUND: In the primary 48-week analysis of a hepatic safety trial in patients with HIV-1 co-infected with hepatitis B virus (HBV) and/or hepatitis C virus (HCV), maraviroc-containing treatment regimens were not associated with increased hepatotoxicity. METHODS: In this randomised, double-blind, placebo-controlled, multicentre study, patients received maraviroc twice daily (n=70) or placebo (n=67) with concomitant antiretroviral therapy for 144 weeks (clinicaltrials...
December 7, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/27924688/susceptibility-to-vaccine-preventable-diseases-and-vaccination-adherence-among-healthcare-workers-in-italy-a-cross-sectional-survey-at-a-regional-acute-care-university-hospital-and-a-systematic-review
#14
Umberto Leone Roberti Maggiore, Carolina Scala, Alessandra Toletone, Nicoletta Debarbieri, Mauro Perria, Beatrice D'Amico, Alfredo Montecucco, Mariano Martini, Guglielmo Dini, Paolo Durando
Healthcare Workers (HCWs) have an increased risk both to acquire and to spread vaccine preventable diseases (VPDs) both to their colleagues and, especially, to vulnerable patients. The prevention of occupational hazards among HCWs is based on proper adoption of the standard and additional precautions, immunizations, and secondary preventive measures, such as post-exposure prophylaxis. Moreover, HCWs are often referred to as the most trusted source of vaccine-related information for their patients. In the present article, we report the findings of a cross-sectional study investigating the compliance to vaccinations among HCWs employed at the Obstetric Unit of a regional acute-care University Hospital in Northern Italy...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27923614/antiviral-therapy-inhibits-viral-reactivation-and-improves-survival-after-repeat-hepatectomy-for-hepatitis-b-virus-related-recurrent-hepatocellular-carcinoma
#15
Shengyu Huang, Yong Xia, Zhengqing Lei, Qifei Zou, Jun Li, Tian Yang, Kui Wang, Zhenlin Yan, Xuying Wan, Feng Shen
BACKGROUND: To explore the impact of antiviral therapy (AVT) on short- and long-term outcomes after re-hepatectomy for patients with recurrent HBV-related hepatocellular carcinoma (HCC). STUDY DESIGN: The data of 583 consecutive patients who underwent re-hepatectomy for intrahepatic recurrence of HBV-related HCC after initial hepatectomy between 2006 and 2011 at the Eastern Hepatobiliary Surgery Hospital were analyzed. Tumor re-recurrence, recurrence to death survival (RTDS) and overall survival (OS) were compared using the Kaplan-Meier method and log-rank test...
December 3, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27922546/use-of-wisteria-floribunda-agglutinin-positive-human-mac-2-binding-protein-in-assessing-risk-of-hepatocellular-carcinoma-due-to-hepatitis-b-virus
#16
Ja Yoon Heo, Seung Up Kim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Young Nyun Park, Sung Soo Ahn, Kwang-Hyub Han, Hyon-Suk Kim
Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA-M2BP) is a serologic marker corresponding with degree of hepatic fibrosis. We evaluated its accuracy in assessing hepatic fibrosis and in predicting the risk of developing hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB).In a 5-year period (2009-2013), a total of 95 CHB patients with available serum WFA-M2BP assay and transient elastography assessment [to assess liver stiffness (LS)] who had undergone liver biopsy were recruited for retrospective analysis...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27922484/adherence-to-follow-up-and-treatment-recommendations-in-greek-and-immigrant-patients-with-chronic-hepatitis-b-in-greece
#17
Theodoros Voulgaris, John Vlachogiannakos, Panagiota Ioannidou, Maria-Vasiliki Papageorgiou, Evi Zampeli, Dimitrios Karagiannakis, Anastasia Georgiou, Afroditi Papazoglou, George Karamanolis, George V Papatheodoridis
BACKGROUND/AIM: Immigrants have multiple barriers to access to health care systems. We evaluated the adherence to follow-up and treatment recommendations of chronic hepatitis B virus (HBV) Greek and immigrant patients. METHODS: In total, 1001 consecutive adult patients with chronic HBV infection who visited our clinics for the first time between 2002 and 2011 were included. All patients born outside Greece were considered immigrants. Diagnosis was considered to be complete if patients could be classified into HBeAg-positive chronic hepatitis B (CHB), inactive carriers, HBeAg-negative CHB, or decompensated cirrhosis...
December 2, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27922198/dnmt1-modulation-in-chronic-hepatitis-b-patients-and-hypothetic-influence-on-mitochondrial-dna-methylation-status-during-long-term-nucleo-t-side-analogues-therapy
#18
Giordano Madeddu, Silvia Ortu, Giovanni Garrucciu, Ivana Maida, Michela Melis, Alberto Augusto Muredda, Maria Stella Mura, Sergio Babudieri
Inhibition of viral replication is the most important goal in patients with Hepatitis B virus chronic infection (CHB). Currently, five oral nucleo(t)side analogues (NAs), including Lamivudine, Adefovir, Telbivudine, Entecavir and Tenofovir, have been approved for treatment. The widespread use of NAs has also been linked with a progressive growth of unlikely anomaly attributable to mitochondrial dysfunctions, not previously recognized. Here we explore the hypothesis that NAs may cause persistent epigenetic changes during prolonged NAs therapy in CHB patients...
December 6, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27920818/exposition-of-hepatitis-b-surface-antigen-hbsag-on-the-surface-of-hek293t-cell-and-evaluation-of-its-expression
#19
Mina Mirian, Razieh Taghizadeh, Hossein Khanahmad, Mansour Salehi, Ali Jahanian-Najafabadi, Hojjat Sadeghi-Aliabadi, Shirin Kouhpayeh
Hepatitis B virus (HBV) is considered as a global health concern and hepatitis B surface antigen (HBsAg) is the most immunogenic protein of HBV. The purpose of this study was to evaluate the expression of HBsAg on the cell surface of human embryonic kidney cell line (HEK293T). After transformation of expression vector pcDNA/HBsAg to E.coli TOP10F', plasmid was extracted and digested with BglII. Afterwards, the linearized vector was transfected to cells and treated with hygromycin B for 5 weeks to expand the resulted clonies...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27920641/severe-de-novo-hepatitis-b-recovered-from-late-onset-liver-insufficiency-with-prolonged-ascites-and-hypoalbuminemia-due-to-hepatitis-b-virus-genotype-bj-with-precore-mutation
#20
Akira Sato, Toshiya Ishii, Fumiaki Sano, Takayuki Yamada, Hideaki Takahashi, Nobuyuki Matsumoto
De novo hepatitis B is associated with a high risk of hepatic failure often resulting in fatal fulminant hepatitis even when nucleotide analogues are administered. A 77-year-old female developed de novo hepatitis B after R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) treatment for diffuse large B-cell lymphoma. Hepatitis B virus (HBV) isolated from the patient was of genotype Bj, with a precore mutation (G1896A) exhibiting an extremely high viral load at the onset of hepatitis...
September 2016: Case Reports in Gastroenterology
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