keyword
https://read.qxmd.com/read/38517275/remimazolam-improves-the-markers-of-post-resuscitation-cerebral-injury-in-a-swine-model-of-cardiac-arrest
#21
JOURNAL ARTICLE
Rongrong Shen, Zhilin Liu, Li Fei, Yixiang Zhang, Linwu Xu, Chaoqi Xuan
INTRODUCTION: Previous studies have manifested that those sedatives acting on γ-aminobutyric acid A (GABAa) receptor could produce effective brain protection against regional and global ischemic stimulation. The present study was designed to investigate the effect of a novel GABAa receptor agonist, remimazolam post-conditioning (RP) on cerebral outcome after global ischemic stimulation induced by cardiac arrest and resuscitation in swine. METHODS: A total of 24 swine were utilized in this study, in which the animals were randomly divided into the following three groups: Sham group (n = 6), CPR group (n = 9), and CPR + RP group (n = 9)...
February 5, 2024: Shock
https://read.qxmd.com/read/38515204/prognostic-value-of-arterial-carbon-dioxide-tension-during-cardiopulmonary-resuscitation-in-out-of-hospital-cardiac-arrest-patients-receiving-extracorporeal-resuscitation
#22
JOURNAL ARTICLE
Pei-I Su, Min-Shan Tsai, Wei-Ting Chen, Chih-Hung Wang, Wei-Tien Chang, Matthew Huei-Ming Ma, Wen-Jone Chen, Chien-Hua Huang, Yih-Sharng Chen
BACKGROUND: Current guidelines on extracorporeal cardiopulmonary resuscitation (ECPR) recommend careful patient selection, but precise criteria are lacking. Arterial carbon dioxide tension (PaCO2 ) has prognostic value in out-of-hospital cardiac arrest (OHCA) patients but has been less studied in patients receiving ECPR. We studied the relationship between PaCO2 during cardiopulmonary resuscitation (CPR) and neurological outcomes of OHCA patients receiving ECPR and tested whether PaCO2 could help ECPR selection...
March 21, 2024: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://read.qxmd.com/read/38510503/assessing-the-cost-effectiveness-of-capnography-for-end-tidal-co-2-monitoring-during-in-hospital-cardiac-arrest-a-middle-income-country-perspective-analysis
#23
JOURNAL ARTICLE
Sérgio Renato da Rosa Decker, Lucas Emanuel Marzzani, Pedro Rotta de Ferreira, Paulo Ricardo Mottin Rosa, Janete Salles Brauner, Regis Goulart Rosa, Eduardo Gehling Bertoldi
STUDY OBJECTIVE: To evaluate the cost-effectiveness of EtCO2 monitoring during in-hospital cardiorespiratory arrest (CA) care outside the intensive care unit (ICU) and emergency room department. DESIGN: We performed a cost-effectiveness analysis based on a simple decision model cost analysis and reported the study using the CHEERS checklist. Model inputs were derived from a retrospective Brazilian cohort study, complemented by information obtained through a literature review...
April 2024: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510376/cerebral-perfusion-and-metabolism-with-mild-hypercapnia-vs-normocapnia-in-a-porcine-post-cardiac-arrest-model-with-and-without-targeted-temperature-management
#24
JOURNAL ARTICLE
Hilde Karlsen, Runar J Strand-Amundsen, Christiane Skåre, Morten Eriksen, Vidar M Skulberg, Kjetil Sunde, Tor Inge Tønnessen, Theresa M Olasveengen
AIM: To determine whether targeting mild hypercapnia (PaCO2 7 kPa) would yield improved cerebral blood flow and metabolism compared to normocapnia (PaCO2 5 kPa) with and without targeted temperature management to 33 °C (TTM33) in a porcine post-cardiac arrest model. METHODS: 39 pigs were resuscitated after 10 minutes of cardiac arrest using cardiopulmonary bypass and randomised to TTM33 or no-TTM, and hypercapnia or normocapnia. TTM33 was managed with intravasal cooling...
June 2024: Resuscitation plus
https://read.qxmd.com/read/38510375/endovascular-aortic-occlusion-improves-return-of-spontaneous-circulation-after-longer-periods-of-cardiopulmonary-resuscitation-a-translational-study-in-pigs
#25
JOURNAL ARTICLE
Steven Siemieniak, Tanner Greiving, Nola Shepard, Jason Rall, Craig Nowadly
INTRODUCTION: Resuscitative endovascular balloon occlusion of the aorta (REBOA) has emerged as an adjunct to CPR for nontraumatic cardiac arrest (NTCA). This translational study investigated the impact of varying low-flow duration (15- vs 30-mins) on REBOA's hemodynamic performance and ability to achieve return of spontaneous circulation (ROSC) in a porcine model. METHODS: Thirty-two pigs were anesthetized and placed into ventricular fibrillation. All animals received a 4-min no-flow period before CPR was initiated...
June 2024: Resuscitation plus
https://read.qxmd.com/read/38507848/cumulative-epinephrine-dose-during-cardiac-arrest-and-neurologic-outcome-after-extracorporeal-cardiopulmonary-resuscitation
#26
JOURNAL ARTICLE
Samuel I Garcia, Troy G Seelhammer, Sahar A Saddoughi, Alexander S Finch, John G Park, Patrick M Wieruszewski
BACKGROUND: Epinephrine is recommended without an apparent ceiling dosage during cardiac arrest. However, excessive alpha- and beta-adrenergic stimulation may contribute to unnecessarily high aortic afterload, promote post-arrest myocardial dysfunction, and result in cerebral microvascular insufficiency in patients receiving extracorporeal cardiopulmonary resuscitation (ECPR). METHODS: This was a retrospective cohort study of adults (≥ 18 years) who received ECPR at large academic ECMO center from 2018 to 2022...
March 15, 2024: American Journal of Emergency Medicine
https://read.qxmd.com/read/38507645/association-of-pediatric-post-cardiac-arrest-ventilation-and-oxygenation-with-survival-outcomes
#27
JOURNAL ARTICLE
Aisha H Frazier, Alexis A Topjian, Ron W Reeder, Ryan W Morgan, Ericka L Fink, Deborah Franzon, Kathryn Graham, Monica L Harding, Peter M Mourani, Vinay M Nadkarni, Heather A Wolfe, Tageldin Ahmed, Michael J Bell, Candice Burns, Joseph A Carcillo, Todd C Carpenter, J Wesley Diddle, Myke Federman, Stuart H Friess, Mark Hall, David A Hehir, Christopher M Horvat, Leanna L Huard, Tensing Maa, Kathleen L Meert, Maryam Y Naim, Daniel Notterman, Murray M Pollack, Carleen Schneiter, Matthew P Sharron, Neeraj Srivastava, Shirley Viteri, David Wessel, Andrew R Yates, Robert M Sutton, Robert A Berg
RATIONALE: Adult and pediatric studies provide conflicting data whether post-cardiac arrest hypoxemia, hyperoxemia, hypercapnia and/or hypocapnia are associated with worse outcomes. OBJECTIVES: Determine if post-arrest hypoxemia or post-arrest hyperoxemia are associated with lower rates of survival to hospital discharge compared to post-arrest normoxemia, and if post-arrest hypocapnia or hypercapnia are associated with lower rates of survival compared to post-arrest normocapnia...
March 20, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38507335/epidemiology-and-outcomes-of-pediatric-cardiac-arrest-in-a-cardiovascular-unit-at-a-public-hospital-in-argentina
#28
JOURNAL ARTICLE
Ricardo Rodríguez, María Althabe, María Ballestrini, Paula Lombardi, Ma Belén Desocio, Mariela Krynski, Ana M Lenz, Mercedes Montonati, Guillermo Moreno, Ma Luísa Pilan, Ma Laura Polo, Juan C Vassallo
BACKGROUND: Children with congenital heart disease present a higher frequency of cardiorespiratory arrest (CRA) than the general pediatric population. The epidemiology of CRA is not exactly known in our setting, nor are the mortality risk or the neurological evolution factors. OBJECTIVE: To describe the epidemiology and outcomes associated with pediatric cardiopulmonary resuscitation in a cardiovascular recovery unit. The primary endpoint was the survival to discharge and the secondary endpoints were the return to spontaneous circulation, the survival at 24 hours and the remote neurological condition...
2024: Archivos de Cardiología de México
https://read.qxmd.com/read/38505075/cerebral-protection-in-acute-type-a-aortic-dissection-surgery-a-systematic-review-and-meta-analysis
#29
JOURNAL ARTICLE
Mehran Rahimi, Hadi Sahrai, Ali Norouzi, Mohammadreza Taban-Sadeghi, Ahmadali Khalili, Sina Hamzehzadeh, Reza Ali Akbari Khoei, Hossein Hosseinifard, Ralf Martz Sulague, Jacques Kpodonu
BACKGROUND: Acute type A aortic dissection (ATAAD) still challenges physicians and warrants emergent surgical management. Two main methods to reduce cerebrovascular events in ATAAD surgeries are antegrade cerebral perfusion (ACP) and retrograde cerebral perfusion (RCP). We conducted a systematic review and meta-analysis to compare the outcomes of ACP and RCP methods during the ATAAD surgery. METHODS: In this study, we searched the databases until March 29th , 2023...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38505015/myocardial-protection-comparing-histological-effects-of-single-dose-cardioplegic-solutions-study-protocol-for-a-secondary-analysis-of-the-cardioplegia-trial
#30
JOURNAL ARTICLE
Kathize Betti Lira, Renan Senandes Delvaux, Felipe Abatti Spadini, Luis Henrique Hauschild, Rafael Oliveira Ceron, Fernando Anschau, Luciane Kopittke, Juarez Rode, Rafael Antônio Widholzer Rey, Estefania Inez Wittke, Alfeu Roberto Rombaldi, Eduardo Cambruzzi, Eron Rodrigues Cunha Lopes, Adriana Silveira Almeida
BACKGROUND: Myocardial protection is crucial for successful cardiac surgery, as it prevents heart muscle damage that can occur during the procedure. Prolonged hypoxia without proper protection can lead to adenosine triphosphate consumption, microvilli loss, blister formation, and edema. Custodiol, del Nido, and modified del Nido are single-dose cardioplegic solutions with proven safety and significance in modern surgery. While each has been independently assessed for patient outcomes, limited research directly compares them...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38505007/analysis-of-the-hemostatic-effect-of-preset-wrapping-technique-for-type-a-aortic-dissection-with-abnormal-coagulation
#31
JOURNAL ARTICLE
Zhixiang Cai, Tao Yan, Ben Zhang, Weida Zhang, Chenjie Su, Hanwei Chen, Xianyue Wang
BACKGROUND: There are many techniques to reduce anastomotic bleeding for the total arch replacement, but hemostasis is sometimes difficult to achieve after surgery for acute dissection, especially in patients with abnormal coagulation (AC). This study aimed to investigate the hemostatic effect and early efficacy of a pre-set bovine pericardium wrapper in the right heart system shunt for total arch replacement in patients with type A aortic dissection (TAAD) and preoperative AC. METHODS: A retrospective analysis was conducted on 85 patients with TAAD and AC who underwent total arch replacement between January 2018 and December 2022...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38504265/postoperative-hyper-inflammation-as-a-predictor-of-poor-outcomes-in-patients-with-acute-type-a-aortic-dissection-ataad-undergoing-surgical-repair
#32
JOURNAL ARTICLE
Yuan-Xi Luo, Yusanjan Matniyaz, Yu-Xian Tang, Yun-Xing Xue, Yi Jiang, Ke Pan, Zhi-Kang Lv, Zhi-Wei Fan, Kuo Wang, Hai-Tao Zhang, He Zhang, Wen-Zhe Wang, Tuo Pan, Dong-Jin Wang, Fu-Dong Fan
BACKGROUND: Postoperative hyper-inflammation is a frequent event in patients with acute Stanford type A aortic dissection (ATAAD) after surgical repair. This study's objective was to determine which inflammatory biomarkers could be used to make a better formula for identifying postoperative hyper-inflammation, and which risk factors were associated with hyper-inflammation. METHODS: A total of 405 patients were enrolled in this study from October 1, 2020 to April 1, 2023...
March 19, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38501716/beyond-the-final-heartbeat-neurological-perspectives-on-normothermic-regional-perfusion-for-organ-donation-after-circulatory-death
#33
REVIEW
Matthew P Kirschen, Ariane Lewis, Michael A Rubin, Panayiotis N Varelas, David M Greer
Normothermic regional perfusion (NRP) has recently been used to augment organ donation after circulatory death (DCD) to improve the quantity and quality of transplantable organs. In DCD-NRP, after withdrawal of life-sustaining therapies and cardiopulmonary arrest, patients are cannulated onto extracorporeal membrane oxygenation to reestablish blood flow to targeted organs including the heart. During this process, aortic arch vessels are ligated to restrict cerebral blood flow. We review ethical challenges including whether the brain is sufficiently reperfused through collateral circulation to allow reemergence of consciousness or pain perception, whether resumption of cardiac activity nullifies the patient's prior death determination, and whether specific authorization for DCD-NRP is required...
March 19, 2024: Annals of Neurology
https://read.qxmd.com/read/38497047/machine-learning-model-to-predict-evolution-of-pulseless-electrical-activity-during-in-hospital-cardiac-arrest
#34
JOURNAL ARTICLE
Jon Urteaga, Andoni Elola, Anders Norvik, Eirik Unneland, Trygve C Eftestøl, Abhishek Bhardwaj, David Buckler, Benjamin S Abella, Eirik Skogvoll, Elisabete Aramendi
BACKGROUND: During pulseless electrical activity (PEA) the cardiac mechanical and electrical functions are dissociated, a phenomenon occurring in 25-42% of in-hospital cardiac arrest (IHCA) cases. Accurate evaluation of the likelihood of a PEA patient transitioning to return of spontaneous circulation (ROSC) may be vital for the successful resuscitation. THE AIM: We sought to develop a model to automatically discriminate between PEA rhythms with favorable and unfavorable evolution to ROSC...
March 2024: Resuscitation plus
https://read.qxmd.com/read/38495223/temporal-trends-in-the-incidence-and-outcomes-of-shock-refractory-ventricular-fibrillation-out-of-hospital-cardiac-arrest
#35
JOURNAL ARTICLE
Abdulrahman Alhenaki, Zainab Alqudah, Brett Williams, Emily Nehme, Ziad Nehme
AIM: We aimed to describe trends in the incidence and outcomes of refractory ventricular fibrillation (RVF) compared to non-refractory ventricular fibrillation (non-RVF) in out-of-hospital cardiac arrest (OHCA). METHODS: Between 2010 and 2019, we included all OHCA cases involving adults ≥ 16 years old with an initial shockable rhythm and who received an attempted resuscitation by Emergency Medical Services (EMS) or a bystander shock prior to EMS arrival in Victoria, Australia...
June 2024: Resuscitation plus
https://read.qxmd.com/read/38486930/implementation-of-an-extracorporeal-resuscitation-ecpr-program-for-out-of-hospital-cardiac-arrest-in-stockholm-sweden-feasibility-safety-and-outcome
#36
JOURNAL ARTICLE
Lis Frykler Abazi, Andreas Liliequist, Felix Böhm, Magnus Hedberg, Moa Simonsson, Anders Bäckman, Malin Ax, Frieder Braunschweig, Linda Mellbin, Rickard Linder, Leif Svensson, Juliane Jurga, Per Nordberg, Mattias Ringh, Sune Forsberg, Jacob Hollenberg
BACKGROUND: The aim of this study was to evaluate the implementation of a novel extra corporeal cardiopulmonary (ECPR) program in the greater Stockholm area with focus on feasibility, safety aspects and clinical outcomes. METHODS: Prospective observational study of ECPR program including patients with OHCA from January 2020 to December 2022, fulfilling ECPR criteria: age 18-65 years, initial shockable rhythm or pulseless electrical activity, witnessed arrest, bystander cardiopulmonary resuscitation and refractory arrest after three cycles of advance cardiac life support...
June 2024: Resuscitation plus
https://read.qxmd.com/read/38486144/voluntary-first-responders-experiences-of-being-dispatched-to-suspected-out-of-hospital-cardiac-arrest-in-rural-areas-an-interview-study
#37
JOURNAL ARTICLE
Camilla Allert, Bengt Nilsson, Anders Svensson, Ewa K Andersson
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) is a leading cause of death, and survival outcomes vary across countries and regions. To improve survival, the European Resuscitation Council Guidelines encourage the implementation of technologies like smartphone applications to alert voluntary first responders (VFRs) who are near a suspected OHCA. VFRs are of great importance in the ´chain of survival´, but there is still a lack of knowledge about their experiences; especially of those operating in rural areas...
March 14, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38485936/extracorporeal-cardio-pulmonary-resuscitation-in-a-patient-with-missed-diagnosis-of-sodium-nitrite-intoxication
#38
JOURNAL ARTICLE
Francesco Gaiani, Marco Giani, Beatrice Vergnano, Jeff Sardella, Fabrizio Cappellini, Marco Casati, Matteo Pozzi, Giuseppe Foti
INTRODUCTION: Critical poisoning with sodium nitrite (NaNO2 ) can present challenges in promptly identifying and managing acute methemoglobinemia. CASE REPORT: We report the case of an overt self-intoxication by an initially unknown agent, leading to cardiac arrest. Despite prodromal signs of cyanosis, coma, desaturation, and hypotension, methemoglobinemia went unrecognized during extracorporeal cardiopulmonary resuscitation (ECPR) as the point-of-care test failed to provide methemoglobin levels, leading to untreated methemoglobinemia...
March 14, 2024: Perfusion
https://read.qxmd.com/read/38481629/takotsubo-cardiomyopathy-triggered-by-frequent-psychogenic-nonepileptic-seizures-a-case-report
#39
Daichi Yomogida, Hiroyuki Kuwano, Tatsuya Miyakoshi, Shiori Mizuta, Shinjiro Horikawa, Yoshinao Koshida
BACKGROUND: Coexistence of Takotsubo cardiomyopathy and psychogenic nonepileptic seizures has rarely been reported. Herein, we report a case of Takotsubo cardiomyopathy triggered by psychogenic nonepileptic seizures. CASE PRESENTATION: A 50-year-old woman with a 22-year history of dissociative and panic disorders and a 7-year history of seizures increasing in frequency was admitted due to cardiogenic shock. Based on the left ventriculography and electroencephalography findings, she was diagnosed with Takotsubo cardiomyopathy and psychogenic nonepileptic seizures...
2024: Acute Medicine & Surgery
https://read.qxmd.com/read/38481627/splenic-injury-caused-by-cardiopulmonary-resuscitation-in-a-full-stomach-with-hematoma-after-hemorrhagic-shock-due-to-bleeding-duodenal-ulcer-a-case-report
#40
Daisuke Fujimori, Tomohide Koyama, Satomi Ooki, Masaaki Ito, Yasutaka Yoshiike, Satoshi Nakamura, Ryuhei Yoshida, So Sakamoto, Chikao Ito, Miyuki Kasuya, Kyoji Oe, Isao Takahashi
BACKGROUND: Cardiopulmonary resuscitation is essential for cardiopulmonary arrest, but complications from chest compressions warrant monitoring. Although rib and sternal fractures are common, abdominal injuries are rare, and splenic injuries are much rarer. CASE PRESENTATION: A 74-year-old man was admitted to the emergency room with a hemorrhagic duodenal ulcer. During hospitalization, the patient went into cardiopulmonary arrest due to hemorrhagic shock. Spontaneous circulation returned after 7 min of cardiopulmonary resuscitation...
2024: Acute Medicine & Surgery
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