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Sameen Khalid, Aamer Abbass, Eric Nellis, Shashin Shah, Hiral Shah
Pancreatic pseudocysts and walled-off pancreatic necrosis arise as a complication of pancreatitis. Multiple fluid collections are seen in 5-20% of the patients who have walled-off peripancreatic fluid collections. There is a paucity of data regarding the role of endoscopic transmural drainage in the management of multiple pancreatic fluid collections. In this case report, we present the case of a 72-year-old male with three walled-off pancreatic fluid collections in the setting of acute necrotizing pancreatitis...
January 9, 2018: Curēus
Matthew J Sullivan, Hope Kincaid, Shashin Shah, Hiral N Shah
Background and study aims:  For suspected pancreaticobiliary malignancies, endobiliary brush cytology during endoscopic retrograde cholangiopancreatography (ERCP) remains the diagnostic test of choice despite historically poor and variable sensitivity. This has led to increased use of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) as an initial test. Recently, our institution began using a cytology brush that was designed specifically to collect a more substantial and higher-quality sample...
December 2017: Endoscopy International Open
Hiroyasu Sakai, Shoko Tabata, Minami Kimura, Saori Yabe, Yosuke Isa, Yuki Kai, Fumiaki Sato, Tetsuro Yumoto, Kanako Miyano, Minoru Narita, Yasuhito Uezono
5-Fluorouracil (5-FU) is widely used as an anti cancer drug and is known to cause severe diarrhea. Recently we suggested that levels of chemokine (C-X-C motif) ligand 1 (CXCL1) and neutrophil recruitment in the colonic mucosa were drastically increased by the 5-FU administration in mice. Hange-shashin-to (HST) is prescribed in Japan for treat gastritis, stomatitis, and inflammatory diarrhea. We therefore examined the effects of HST and its active ingredients on 5-FU-induced CXCL1 upregulation in cultured colon tissue, and also examined the effects of HST on 5-FU-induced diarrhea development in the mouse...
2017: Biological & Pharmaceutical Bulletin
Neha Singh, Hitesh Dhiman, Sadaf Shaikh, Purvish Shah, Roma Sarkar, Shashin Patel
The present research was conducted to study the urbanization of Vadodara city and to monitor the ambient noise level in the industrial, commercial, residential and silence zones of the city. A settlement map created by unsupervised classification for the land use and land cover study of Vadodara city clearly shows the increasing pattern of urbanization in its central part, which may be the result of urban sprawl due to migration of people from the rural to the urban areas. The fluctuation in ambient noise level was recorded using an A-weighted sound level meter in all the four zones of Vadodara city for 3 h at regular intervals of 15 min on 3 consecutive days at the same time...
December 1, 2016: Reviews on Environmental Health
Christopher J DiMaio, Jennifer M Kolb, Petros C Benias, Hiral Shah, Shashin Shah, Oleh Haluszka, Jennifer Maranki, Kaveh Sharzehi, Eric Lam, Stuart R Gordon, Sarah M Hyder, Pavlos Z Kaimakliotis, Satya B Allaparthi, Frank G Gress, Amrita Sethi, Ashish R Shah, Jose Nieto, Vivek Kaul, Shivangi Kothari, Truptesh H Kothari, Sammy Ho, Manhal J Izzy, Neil R Sharma, Rabindra R Watson, V Raman Muthusamy, Douglas K Pleskow, Tyler M Berzin, Mandeep Sawhney, Emad Aljahdi, Marvin Ryou, Clarence K Wong, Parantap Gupta, Dennis Yang, Susana Gonzalez, Douglas G Adler
BACKGROUND AND AIMS: The ability to safely and effectively obtain sufficient tissue for pathologic evaluation by using endoscopic ultrasound (EUS) guidance remains a challenge. Novel designs in EUS needles may provide for improved ability to obtain such core biopsies. The aim of this study was to evaluate the diagnostic yield of core biopsy specimens obtained using a novel EUS needle specifically designed to obtain core biopsies. PATIENTS AND METHODS: Multicenter retrospective review of all EUS-guided fine-needle biopsies obtained using a novel biopsy needle (SharkCore FNB needle, Medtronic, Dublin, Ireland)...
September 2016: Endoscopy International Open
O V Petrova, S A Shashin, D G Tarasov, E R Jukova, E V Panova, N P Gracheva
The modern international standards recommend each laboratory to develop or to confirm available in literature the reference intervalsfor every laboratory indicator In the Astrakhanskaia oblast, sampling of128 healthy males andfemales were examinedfor aggregation function of thrombocytes using impedance technique and applying aggregometer Multiplate ("Verum Diagnostica", Germany). The study used as inductors peptide activating receptor of thrombin; arachidonic and adenosine diphosphoric acids. The reference range of aggregation of thrombocytes with peptide activating receptor of thrombin, at aggregometer Multiplate, in healthy population of theAstrakhanskaia oblast made up to 815...
January 2016: Klinicheskaia Laboratornaia Diagnostika
Nobuhiro Hoshi, Yasuhide Kofunato, Rei Yashima, Tatsuo Shimura, Seiichi Takenoshita
OBJECTIVES: FOLFIRINOX is an effective therapy for unresectable advanced pancreatic cancer. However, FOLFIRINOX has side effects of blood and gastrointestinal toxicity. Diarrhea, one of the side effects of CPT-11, sometimes becomes serious. We studied whether Hange-shashin-to could prevent diarrhea caused by CPT-11. METHODS: Seven patients who were diagnosed with unresectable pancreatic cancer, either Stage Ⅳor recurrent disease, were enrolled. They took 2.5 g of Hange-shashin-to before each meal starting one day before FOLFIRINOX, and continued taking it for one week...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
O V Petrova, S A Shashin, D G Tarasov
The study of markers of systemic inflammatory response in patients with infectious endocarditis showed that at admittance they had elevated blood C-reactive protein and ferritin levels while leukocyte count and fibrinogen content remained normal. C-reactive protein and ferritin levels increased on day 1 of the postoperative period and tended to grow further on day 3 when both parameters reached maximum values; they started to decrease on day 6 These data indicate that C-reactive protein and ferritin levels can be used to characterise the postoperative conditions of the patients including manifestations of systemic inflammation and outcome of surgical treatment...
2015: Klinicheskaia Meditsina
Ayumu Kuwamura, Nobuyasu Komasawa, Kazuyoshi Kori, Motoshige Tanaka, Toshiaki Minami
OBJECTIVES: The present study aimed to determine the efficacy of Hange-Shashin-To (HST), a Kampo medicine, in treating postoperative sore throat and nausea. DESIGN: This randomized, controlled, double-blind study was conducted among two groups of adult female patients who were scheduled to undergo benign laparoscopic surgery under general anesthesia. All patients in each group had a physical status of either 1 (normal, healthy patient) or 2 (patient with a mild systemic disease), according to the American Society of Anesthesiologists...
August 2015: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Ou Yamaguchi, Akiko Kawashima, Ayako Shiono, Yuri Maeno, Rinako Ishikawa, Ai Masumoto, Harue Utsugi, Hisayoshi Daito, Tetsuya Okano, Yoshitake Murayama, Kunihiko Kobayashi
Afatinib is an epidermal growth factor receptor-tyrosine kinase inhibitor(EGFR-TKI). In a randomized phase III study(Lux- Lung 3 study)employing patients harboring EGFR mutations, patients administered afatinib show a significantly longer progression free survival time(PFS)than those administeredcombination chemotherapy comprising cisplatin andpemetrexed . However, most of the patients(95.2%)treatedwith afatinib experiencedd iarrhea. In the present report, 16 patients with EGFR mutations were treatedby afatinib at our institution from May 2014 to December 2014...
May 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
David Ross, Tristan Maerz, Michael Kurdziel, Joel Hein, Shashin Doshi, Asheesh Bedi, Kyle Anderson, Kevin Baker
BACKGROUND: The failure rate of tendon-bone healing after repair of rotator cuff tears remains high. A variety of biologic- and cell-based therapies aimed at improving rotator cuff healing have been investigated, and stem cell-based techniques have become increasingly more common. However, most studies have focused on the implantation of exogenous cells, which introduces higher risk and cost. We aimed to improve rotator cuff healing by inducing endogenous stem cell mobilization with systemic administration of granulocyte-colony stimulating factor (G-CSF)...
May 2015: Clinical Orthopaedics and related Research
Rie Takagi, Masaaki Kawano, Kazuyuki Nakagome, Kumiko Hashimoto, Takehiro Higashi, Katsuya Ohbuchi, Atsushi Kaneko, Sho Matsushita
Allergic airway inflammation is generally considered to be a Th2-type immune response. Recent studies, however, have demonstrated that Th17-type immune responses also play important roles in this process, particularly in the pathogenesis of neutrophilic airway inflammation, a hallmark of severe asthma. We scrutinized several Kampo extracts that reportedly exhibit anti-inflammatory activity by using in vitro differentiation system of human and mouse naïve T cells. We found that hange-shashin-to (HST) and oren-gedoku-to (OGT) possess inhibitory activity for Th17 responses in vitro...
2014: International Journal of Inflammation
Jonathan W Olsen, Richard L Barger, Shashin K Doshi
OBJECTIVE: The number of procedures conducted within the radiology department using moderate sedation is rising. Anecdotal evidence suggests that there is an inconsistency in the education of radiology trainees regarding moderate sedation. CONCLUSION: The purpose of this article is to give an overview and concise summary of the use of moderate sedation as put forth by the American Society of Anesthesia, American College of Radiology, and Society of Interventional Radiology...
November 2013: AJR. American Journal of Roentgenology
Shun Takaku, Eiichi Osono, Hideki Kuribayashi, Chizuno Takaku, Naoki Hirama, Hidemi Takahashi
OBJECTIVE: Migraine is a common neurologic condition characterized by the disabling effects it has on the patient. Despite recent progress in drug development, better pharmacotherapies against migraine are still needed. This report describes an herbal medicine that has a strong pain-relieving effect against migraine. PATIENT: This case involved a 49-year-old woman with a 16-year history of headaches. Migraine without aura had been diagnosed at age 47 years. Despite taking antiepileptic drugs as prophylaxis, she had migraines almost three times a week, especially in the morning...
December 2013: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Mayuko Sakanashi, Toshihiro Matsuzaki, Katsuhiko Noguchi, Junko Nakasone, Makiko Sakanashi, Taro Uchida, Mika Kina-Tanada, Haruaki Kubota, Kumiko Arakaki, Akihide Tanimoto, Nobuyuki Yanagihara, Matao Sakanashi, Yusuke Ohya, Hiroaki Masuzaki, Shogo Ishiuchi, Kazuhiro Sugahara, Masato Tsutsui
BACKGROUND: Hormone replacement therapy has failed to reduce ischemic cardiovascular events in climacteric women. To explore alternative therapy, we examined whether san'o-shashin-to (TJ-113), a kampo medicine, ameliorates cardiac ischemia-reperfusion (IR) injury in a climacteric rat model. METHODS AND RESULTS: Cardiac function and infarct size after IR were significantly exacerbated in ovariectomized rats as compared with sham-operated rats, whereas long-term treatment with a clinical dosage of TJ-113 for 4 weeks markedly improved these functional and morphological changes...
2013: Circulation Journal: Official Journal of the Japanese Circulation Society
Yoshihiko Kito, Noriyoshi Teramoto
The Japanese Kampo medicines Hange-shashin-to (TJ-14) and Keishi-ka-shakuyaku-to (TJ-60) have been used to treat symptoms of human diarrhea on an empirical basis as Japanese traditional medicines. However, it remains unclear how these drugs affect smooth muscle tissues in the distal colon. The aim of the present study was to investigate the effects of TJ-14 and TJ-60 on the contractile activity of circular smooth muscle from the rat distal colon. TJ-14 and TJ-60 (both 1 mg/ml) inhibited spontaneous contractions of circumferentially cut preparations with the mucosa intact...
November 1, 2012: American Journal of Physiology. Gastrointestinal and Liver Physiology
Yusuke Ueno, Hiroko Matsuda, Hideki Mizutani, Takuya Iwamoto, Masahiro Okuda
The aim of this study was to elucidate the characteristics of the transport of lactone and carboxylate forms of SN-38 (SN-38L and SN-38C, respectively), a metabolite of irinotecan hydrochloride (CPT-11), with the human intestinal epithelial cell line, Caco-2. We examined SN-38L and SN-38C uptake from the apical side into Caco-2, and the effects of various compounds on the uptake of SN-38L. SN-38L and SN-38C in the cells were determined by HPLC with a fluorescence detector. When either SN-38L (0.5 µM) or SN-38C (0...
2012: Biological & Pharmaceutical Bulletin
George Arnold, Saifuddin Vohra, David Marcantonio, Shashin Doshi
This article discusses anatomic relationships, anatomic variants, and MRI protocols that pertain to the foot and ankle. MR images with detailed anatomic description form the cornerstone of this article. The superb image quality will facilitate learning normal imaging anatomy, as well as conceptualizing spatial relationships of anatomic structures.
August 2011: Magnetic Resonance Imaging Clinics of North America
Saifuddin Vohra, George Arnold, Shashin Doshi, David Marcantonio
Magnetic resonance (MR) imaging is the preferred imaging modality for evaluating internal derangement of the knee, due to its superior soft tissue contrast resolution, multiplanar imaging capability, and lack of ionizing radiation. The superb image quality facilitates learning of normal imaging anatomy and conceptualizing spatial relationships of anatomic structures, leading to improved understanding of pathologic processes, mechanisms of injury, and injury patterns, and ultimately increased diagnostic accuracy...
August 2011: Magnetic Resonance Imaging Clinics of North America
Saifuddin Vohra, George Arnold, Shashin Doshi, David Marcantonio
Magnetic resonance (MR) imaging is the modality of choice for evaluating the soft tissues of the thigh and leg because of its superior soft tissue contrast resolution, multiplanar imaging capability, and lack of ionizing radiation. The superb image quality facilitates learning normal imaging anatomy, which ultimately forms the foundation of diagnostic interpretation. The purpose of this article is twofold: (1) depict normal MR anatomy throughout the thigh and leg using representative MR images, emphasizing a compartmental approach; and (2) describe and explain the rationale of standard imaging protocols...
August 2011: Magnetic Resonance Imaging Clinics of North America
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