keyword
MENU ▼
Read by QxMD icon Read
search

Kenya hiv

keyword
https://www.readbyqxmd.com/read/28924616/soil-transmitted-helminth-infections-are-not-associated-with-compromised-antibody-responses-to-previously-administered-measles-and-tetanus-vaccines-among-hiv-1-infected-art-na%C3%A3-ve-kenyan-adults
#1
Helen L Storey, Benson Singa, Jackie Naulikha, Helen Horton, Barbra A Richardson, Grace John-Stewart, Judd L Walson
In many regions of sub-Saharan Africa, both HIV and helminth infections are prevalent. HIV-1 (human immunodeficiency virus type 1) and helminth infections can both compromise immune responses in humans. To determine whether the presence of helminth infection or the treatment of helminth infection alters unstimulated vaccine responses among HIV-1 infected individuals, we conducted two nested serologic studies. Blood samples were collected for HIV disease monitoring and vaccine-specific serologic assays, while stool was evaluated by direct microscopy methods...
February 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/28904953/nonpaternity-and-half-siblingships-as-objective-measures-of-extramarital-sex-mathematical-modeling-and-simulations
#2
Ryosuke Omori, Nico Nagelkerke, Laith J Abu-Raddad
BACKGROUND: Understanding the epidemiology of HIV and other sexually transmitted infections (STIs) requires knowledge of sexual behavior, but self-reported behavior has limitations. We explored the reliability and validity of nonpaternity and half-siblings ratios as biomarkers of current and past extramarital sex. METHODS: An individual-based Monte Carlo simulation model was constructed to describe partnering and conception in human populations with a focus on Sub-Saharan Africa (SSA)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28903628/what-motivates-serodiscordant-couples-to-prevent-hiv-transmission-within-their-relationships-findings-from-a-prep-implementation-study-in-kenya
#3
Rena C Patel, Anna M Leddy, Josephine Odoyo, Keerthana Anand, Gaelen Stanford-Moore, Imeldah Wakhungu, Elizabeth A Bukusi, Jared M Baeten, Joelle M Brown
With the planned scale-up of pre-exposure prophylaxis (PrEP) for HIV prevention among serodiscordant couples in resource-limited settings, gaining an understanding of what motivates serodiscordant couples to prevent HIV is critical. We conducted 44 semi-structured, in-depth individual or couple interviews with 63 participants (33 HIV-infected and 30 HIV-uninfected participants) enrolled in a prospective implementation study of oral antiretroviral-based prevention in Kisumu, Kenya. Transcripts were iteratively analysed using inductive content analysis...
September 14, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28902680/multicountry-validation-of-samba-a-novel-molecular-point-of-care-test-for-hiv-1-detection-in-resource-limited-setting
#4
Johnson Ondiek, Zikulah Namukaya, Sekesai Mtapuri-Zinyowera, Suna Balkan, Ali Elbireer, Ines Ushiro Lumb, Charles Kiyaga, Neha Goel, Allyson Ritchie, Patience Ncube, Kenneth Omuomu, Kenneth Ndiege, Adeodata Kekitiinwa, Douglas Mangwanya, Mary G Fowler, Lou Nadala, Helen Lee
INTRODUCTION: Early diagnosis of HIV-1 infection and the prompt initiation of antiretroviral therapy are critical to achieving a reduction in the morbidity and mortality of infected infants. The Simple AMplification-Based Assay (SAMBA) HIV-1 Qual Whole Blood Test was developed specifically for early infant diagnosis and prevention of mother-to-child transmission programs implemented at the point-of-care in resource-limited settings. METHODS: We have evaluated the performance of this test run on the SAMBA I semiautomated platform with fresh whole blood specimens collected from 202 adults and 745 infants in Kenya, Uganda, and Zimbabwe...
October 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28899162/high-levels-of-viral-suppression-among-east-african-hiv-infected-women-and-men-in-serodiscordant-partnerships-initiating-antiretroviral-therapy-with-high-cd4-counts-and-during-pregnancy
#5
Andrew Mujugira, Jared Baeten, Lara Kidoguchi, Jessica Haberer, Connie Celum, Deborah Donnell, Kenneth Ngure, Elizabeth Bukusi, Nelly Mugo, Stephen Asiimwe, Josephine Odoyo, Edna Tindimwebwa, Nulu Bulya, Elly Katabira, Renee Heffron
BACKGROUND: People who are asymptomatic and feel healthy, including pregnant women, may be less motivated to initiate ART or achieve high adherence. We assessed whether ART initiation, and viral suppression 6, 12 and 24-months after ART initiation, were lower in HIV-infected members of serodiscordant couples who initiated during pregnancy or with higher CD4 counts. METHODS: We used data from the Partners Demonstration Project, an open-label study of the delivery of integrated PrEP and ART (at any CD4 count) for HIV prevention among high-risk HIV serodiscordant couples in Kenya and Uganda...
September 13, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28894986/fertility-intentions-pregnancy-and-use-of-prep-and-art-for-safer-conception-among-east-african-hiv-serodiscordant-couples
#6
Renee Heffron, Kerry Thomson, Connie Celum, Jessica Haberer, Kenneth Ngure, Nelly Mugo, Elizabeth Bukusi, Elly Katabira, Josephine Odoyo, Nulu Bulya, Stephen Asiimwe, Edna Tindimwebwa, Jared M Baeten
African HIV serodiscordant couples often desire pregnancy, despite sexual HIV transmission risk during pregnancy attempts. Pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) reduce HIV risk and can be leveraged for safer conception but how well these strategies are used for safer conception is not known. We conducted an open-label demonstration project of the integrated delivery of PrEP and ART among 1013 HIV serodiscordant couples from Kenya and Uganda followed quarterly for 2 years. We evaluated fertility intentions, pregnancy incidence, the use of PrEP and ART during peri-conception, and peri-conception HIV incidence...
September 11, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28894259/cd161-identifies-polyfunctional-th1-th17-cells-in-the-genital-mucosa-that-are-depleted-in-hiv-infected-female-sex-workers-from-nairobi-kenya
#7
Geneviève Boily-Larouche, Kenneth Omollo, Julianna Cheruiyot, Jane Njoki, Makobu Kimani, Joshua Kimani, Julius Oyugi, Julie Lajoie, Keith R Fowke
CD161 identifies a subset of circulating Th17 cells that are depleted in the blood and gut of HIV-infected individuals. In the female reproductive tract (FRT), the pattern of CD161 expression on CD4(+) cells remains unknown. Here, we characterized CD161 expression in the FRT of Kenyan female sex workers (FSW). Compared to the blood, CD161(+)CD4(+) T cells were enriched in the FRT of uninfected FSWs. These cells were depleted in FRT of HIV-infected FSWs. Cervical CD161(+) cells harboured an activated phenotype (CD69, CD95, HLA-DR) with elevated expression of tissue-homing markers (CCR6, β7 integrin) and HIV co-receptor (CCR5)...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893304/preventing-hiv-infection-without-targeting-the-virus-how-reducing-hiv-target-cells-at-the-genital-tract-is-a-new-approach-to-hiv-prevention
#8
REVIEW
Julie Lajoie, Lucy Mwangi, Keith R Fowke
For over three decades, HIV infection has had a tremendous impact on the lives of individuals and public health. Microbicides and vaccines studies have shown that immune activation at the genital tract is a risk factor for HIV infection. Furthermore, lower level of immune activation, or what we call immune quiescence, has been associated with a lower risk of HIV acquisition. This unique phenotype is observed in highly-exposed seronegative individuals from different populations including female sex workers from the Pumwani cohort in Nairobi, Kenya...
September 12, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28880904/prospective-comparison-of-two-models-of-integrating-early-infant-male-circumcision-with-maternal-child-health-services-in-kenya-the-mtoto-msafi-mbili-study
#9
Robert C Bailey, Fredrick Adera, Mary Ellen Mackesy-Amiti, Timothy Adipo, Sherry K Nordstrom, Supriya D Mehta, Walter Jaoko, F L Fredrik G Langi, Walter Obiero, Edmon Obat, Fredrick O Otieno, Marisa R Young
As countries scale up adult voluntary medical male circumcision (VMMC) for HIV prevention, they are looking ahead to long term sustainable strategies, including introduction of early infant male circumcision (EIMC). To address the lack of evidence regarding introduction of EIMC services in sub-Saharan African settings, we conducted a simultaneous, prospective comparison of two models of EIMC service delivery in Homa Bay County, Kenya. In one division a standard delivery package (SDP) was introduced and included health facility-based provision of EIMC services with community engagement for client referral versus in a different division a standard package plus (SDPplus) that included community-delivered EIMC services...
2017: PloS One
https://www.readbyqxmd.com/read/28880880/volunteer-motivators-for-participating-in-hiv-vaccine-clinical-trials-in-nairobi-kenya
#10
Borna A Nyaoke, Gaudensia N Mutua, Rose Sajabi, Delvin Nyasani, Marianne W Mureithi, Omu A Anzala
BACKGROUND: 1.5 million Kenyans are living with HIV/AIDS as per 2015 estimates. Though there is a notable decline in new HIV infections, continued effort is still needed to develop an efficacious, accessible and affordable HIV vaccine. HIV vaccine clinical trials bear risks, hence a need to understand volunteer motivators for enrolment, retention and follow-up. Understanding the factors that motivate volunteers to participate in a clinical trial can help to strategize, refine targeting and thus increase enrolment of volunteers in future HIV vaccine clinical trials...
2017: PloS One
https://www.readbyqxmd.com/read/28865422/updating-vital-status-by-tracking-in-the-community-among-patients-with-epidemic-kaposi-sarcoma-who-are-lost-to-follow-up-in-sub-saharan-africa
#11
Aggrey Semeere, Esther Freeman, Megan Wenger, David Glidden, Mwebesa Bwana, Micheal Kanyesigye, Fredrick Chite Asirwa, Elyne Rotich, Naftali Busakhala, Emmanuel Oga, Elima Jedy-Agba, Vivian Kwaghe, Kenneth Iregbu, Clement Adebamowo, Antoine Jaquet, Francois Dabis, Sam Phiri, Julia Bohlius, Matthias Egger, Constantin T Yiannoutsos, Kara Wools-Kaloustian, Jeffrey Martin
BACKGROUND: Throughout most of sub-Saharan Africa (and, indeed, most resource-limited areas), lack of death registries prohibits linkage of cancer diagnoses and precludes the most expeditious approach to determining cancer survival. Instead, estimation of cancer survival often uses clinical records, which have some mortality data but are replete with patients who are lost to follow-up (LTFU), some of which may be caused by undocumented death. The end result is that accurate estimation of cancer survival is rarely performed...
September 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28851770/shifting-tasks-from-pharmacy-to-non-pharmacy-personnel-for-providing-antiretroviral-therapy-to-people-living-with-hiv-a-systematic-review-and-meta-analysis
#12
Nyanyiwe Masingi Mbeye, Olatunji Adetokunboh, Eyerusalem Negussie, Tamara Kredo, Charles Shey Wiysonge
OBJECTIVES: Lay people or non-pharmacy health workers with training could dispense antiretroviral therapy (ART) in resource-constrained countries, freeing up time for pharmacists to focus on more technical tasks. We assessed the effectiveness of such task-shifting in low-income and middle-income countries. METHOD: We conducted comprehensive searches of peer-reviewed and grey literature. Two authors independently screened search outputs, selected controlled trials, extracted data and resolved discrepancies by consensus...
August 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28845463/contraceptive-vaginal-ring-experiences-among-women-and-men-in-kisumu-kenya-a-qualitative-study
#13
E McLellan-Lemal, K Ondeng'e, D A Gust, M Desai, F O Otieno, P A Madiega, B Nyagol, E M Makanga
BACKGROUND: Future HIV prevention options for women will likely include Antiretroviral (ARV)-based intravaginal rings. Valuable insights may be gained by examining user experiences with a similar licensed technology, a contraceptive ring, especially in settings where this technology may not be currently available. METHODS: In-depth interviews with 24 females enrolled in a trial assessing acceptability and use of a contraceptive ring, and 20 male sexual partners were conducted September 2014-April 2015...
March 2017: Frontiers in Women's Health
https://www.readbyqxmd.com/read/28831171/mapping-the-spatial-variability-of-hiv-infection-in-sub-saharan-africa-effective-information-for-localized-hiv-prevention-and-control
#14
Diego F Cuadros, Jingjing Li, Adam J Branscum, Adam Akullian, Peng Jia, Elizabeth N Mziray, Frank Tanser
Under the premise that in a resource-constrained environment such as Sub-Saharan Africa it is not possible to do everything, to everyone, everywhere, detailed geographical knowledge about the HIV epidemic becomes essential to tailor programmatic responses to specific local needs. However, the design and evaluation of national HIV programs often rely on aggregated national level data. Against this background, here we proposed a model to produce high-resolution maps of intranational estimates of HIV prevalence in Kenya, Malawi, Mozambique and Tanzania based on spatial variables...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28830492/exploring-provider-perspectives-on-respectful-maternity-care-in-kenya-work-with-what-you-have
#15
Charity Ndwiga, Charlotte E Warren, Julie Ritter, Pooja Sripad, Timothy Abuya
BACKGROUND: Promoting respect and dignity is a key component of providing quality care during facility-based childbirth and is becoming a critical indicator of maternal health care. Providing quality care requires essential skills and attitudes from healthcare providers, as their role is central to optimizing interventions in maternity settings. METHODS: In 13 facilities in Kenya we conducted a mixed methods, pre-post study design to assess health providers' perspectives of a multi-component intervention (the Heshima project), which aimed to mitigate aspects of disrespect and abuse during facility-based childbirth...
August 22, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28828875/factors-contributing-to-antiretroviral-drug-adherence-among-adults-living-with-hiv-or-aids-in-a-kenyan-rural-community
#16
Mary T Kioko, Anne M Pertet
BACKGROUND: Antiretroviral (ARV) adherence of ≥ 95% is recommended for suppressing HIV. However, studies have shown that the ≥ 95% recommended level is rarely achieved. OBJECTIVE: This cross-sectional community-based study sought to assess factors contributing to ARV drug adherence among adults living with HIV or AIDS. SETTING: The study was conducted in a rural community in Machakos County, Kenya. METHODS: The questions used for the study were adapted from the Patient Medicine Adherence Questionnaire (PMAQ), a tool grounded in the Health Belief Model...
July 31, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/28826229/offering-self-administered-oral-hiv-testing-to-truck-drivers-in-kenya-to-increase-testing-a-randomized-controlled-trial
#17
Elizabeth A Kelvin, Gavin George, Eva Mwai, Eston Nyaga, Joanne E Mantell, Matthew L Romo, Jacob O Odhiambo, Lila Starbuck, Kaymarlin Govender
We conducted a randomized controlled trial among 305 truck drivers from two North Star Alliance roadside wellness clinics in Kenya to see if offering HIV testing choices would increase HIV testing uptake. Participants were randomized to be offered (1) a provider-administered rapid blood (finger-prick) HIV test (i.e., standard of care [SOC]) or (2) a Choice between SOC or a self-administered oral rapid HIV test with provider supervision in the clinic. Participants in the Choice arm who refused HIV testing in the clinic were offered a test kit for home use with phone-based posttest counseling...
August 21, 2017: AIDS Care
https://www.readbyqxmd.com/read/28821530/whisper-or-shout-study-protocol-of-a-cluster-randomised-controlled-trial-assessing-mhealth-sexual-reproductive-health-and-nutrition-interventions-among-female-sex-workers-in-mombasa-kenya
#18
Frances H Ampt, Collins Mudogo, Peter Gichangi, Megan S C Lim, Griffins Manguro, Matthew Chersich, Walter Jaoko, Marleen Temmerman, Marilyn Laini, Liz Comrie-Thomson, Mark Stoové, Paul A Agius, Margaret Hellard, Kelly L'Engle, Stanley Luchters
INTRODUCTION: New interventions are required to reduce unintended pregnancies among female sex workers (FSWs) in low- and middle-income countries and to improve their nutritional health. Given sex workers' high mobile phone usage, repeated exposure to short messaging service (SMS) messages could address individual and interpersonal barriers to contraceptive uptake and better nutrition. METHODS: In this two-arm cluster randomised trial, each arm constitutes an equal-attention control group for the other...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28819541/mortality-among-5-17-year-old-children-in-kenya
#19
Bonface Ombaba Osano, Fred Were, Shanaaz Mathews
INTRODUCTION: Global mortality trends have changed over time and are expected to continue changing with a reduction in communicable diseases and an increase of non-communicable disease. Increased survival of children beyond five years may change mortality patterns for these children. There are few studies in Africa that explore the causes of mortality in children over five years. The objective of this study was to determine the mortality rate and clinical profiles of children aged 5-17 years who died in six Kenyan hospitals in 2013...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28814295/the-effect-of-facility-based-antiretroviral-therapy-programs-on-outpatient-services-in-kenya-and-uganda
#20
Alexandra Wollum, Emily Dansereau, Nancy Fullman, Jane Achan, Kelsey A Bannon, Roy Burstein, Ruben O Conner, Brendan DeCenso, Anne Gasasira, Annie Haakenstad, Michael Hanlon, Gloria Ikilezi, Caroline Kisia, Aubrey J Levine, Samuel H Masters, Pamela Njuguna, Emelda A Okiro, Thomas A Odeny, D Allen Roberts, Emmanuela Gakidou, Herbert C Duber
BACKGROUND: Considerable debate exists concerning the effects of antiretroviral therapy (ART) service scale-up on non-HIV services and overall health system performance in sub-Saharan Africa. In this study, we examined whether ART services affected trends in non-ART outpatient department (OPD) visits in Kenya and Uganda. METHODS: Using a nationally representative sample of health facilities in Kenya and Uganda, we estimated the effect of ART programs on OPD visits from 2007 to 2012...
August 16, 2017: BMC Health Services Research
keyword
keyword
14541
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"