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https://www.readbyqxmd.com/read/28228550/interaction-of-phosphorylated-rab11-fip2-with-eps15-regulates-apical-junction-composition
#1
Lynne A Lapierre, Elizabeth H Manning, Kenya M Mitchell, Cathy M Caldwell, James R Goldenring
MARK2 regulates the establishment of polarity in MDCK cells in part through phosphorylation of serine 227 of Rab11-FIP2. We have now identified Eps15 as an interacting partner of phospho-S227-Rab11-FIP2 (pS227-FIP2). During recovery from low calcium, Eps15 localized to the lateral membrane, prior to pS227-FIP2 arrival. Later in recovery, Eps15 and pS227-FIP2 co-localized at the lateral membrane. In MDCK cells expressing the pseudophosphorylated FIP2 mutant, FIP2(S227E), during recovery from low calcium, Eps15 was trapped and never localized to the lateral membrane...
February 22, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28228160/assessment-of-lymphatic-filariasis-prior-to-re-starting-mass-drug-administration-campaigns-in-coastal-kenya
#2
Sammy M Njenga, Henry M Kanyi, Faith M Mutungi, Collins Okoyo, Hadley S Matendechero, Rachel L Pullan, Katherine E Halliday, Simon J Brooker, C Njeri Wamae, Joyce K Onsongo, Kimberly Y Won
BACKGROUND: Lymphatic filariasis (LF) is a debilitating disease associated with extensive disfigurement and is one of a diverse group of diseases referred to as neglected tropical diseases (NTDs) which mainly occur among the poorest populations. In line with global recommendations to eliminate LF, Kenya launched its LF elimination programme in 2002 with the aim to implement annual mass drug administration (MDA) in order to interrupt LF transmission. However, the programme faced financial and administrative challenges over the years such that sustained annual MDA was not possible...
February 22, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28225342/outcomes-from-the-first-multidrug-resistant-tuberculosis-programme-in-kenya
#3
H Huerga, M Bastard, M Kamene, S Wanjala, A Arnold, N Oucho, I Chikwanha, F Varaine
SETTING: In March 2006, the first multidrug-resistant tuberculosis (MDR-TB) treatment programme was implemented in Kenya. OBJECTIVE: To describe patients' treatment outcomes and adverse events. DESIGN: A retrospective case note review of patients started on MDR-TB treatment at two Médecins Sans Frontières-supported sites and the national referral hospital of Kenya was undertaken. Sites operated an ambulatory model of care. Patients were treated for a minimum of 24 months with at least 4-5 drugs for the intensive phase of treatment, including an injectable agent...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28225338/potential-biomarkers-associated-with-discrimination-between-latent-and-active-pulmonary-tuberculosis
#4
R Kamakia, S Kiazyk, J Waruk, A Meyers, J Ochanda, T B Ball, J Oyugi
SETTING: A third of the world's population has latent tuberculous infection (LTBI). Current TB diagnostics used in developing countries are ineffective and are unable to distinguish LTBI from active TB. Identifying biomarkers that could aid in the early detection of TB and in distinguishing TB states could be a major breakthrough in global TB control. OBJECTIVE: To identify potential immune biomarkers to distinguish active TB from LTBI. DESIGN: A cross-sectional study was conducted among 19 active TB patients, 8 TB-negative individuals (controls) and 16 LTBI non-human immunodeficiency virus infected individuals in Nairobi, Kenya...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28225335/integrating-tuberculosis-screening-in-kenyan-prevention-of-mother-to-child-transmission-programs
#5
L M Cranmer, A Langat, K Ronen, C J McGrath, S LaCourse, J Pintye, B Odeny, B Singa, A Katana, L Nganga, J Kinuthia, G John-Stewart
BACKGROUND: Tuberculosis (TB) screening in Prevention of Mother-To-Child Transmission (PMTCT) programs is important to improve TB detection, prevention and treatment. METHODS: As part of a national PMTCT program evaluation, mother-infant pairs attending 6-week and 9-month immunization visits were enrolled at 141 maternal and child health clinics throughout Kenya. Clinics were selected using population-proportion-to-size sampling with oversampling in a high human immunodeficiency virus (HIV) prevalence region...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28224262/characterisation-of-adopters-and-non-adopters-of-dairy-technologies-in-ethiopia-and-kenya
#6
E G Kebebe, S J Oosting, I Baltenweck, A J Duncan
While there is a general consensus that using dairy technologies, such as improved breeds of dairy cows, can substantially increase farm productivity and income, adoption of such technologies has been generally low in developing countries. The underlying reasons for non-adoption of beneficial technologies in the dairy sector are not fully understood. In this study, we characterised adopters and non-adopters of dairy technologies in Ethiopia and Kenya based on farmers' resources ownership in order to identify why many farmers in Ethiopia and Kenya have not adopted improved dairy technologies...
February 21, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28224000/co-inoculation-effect-of-rhizobia-and-plant-growth-promoting-rhizobacteria-on-common-bean-growth-in-a-low-phosphorus-soil
#7
Hezekiah Korir, Nancy W Mungai, Moses Thuita, Yosef Hamba, Cargele Masso
Nitrogen (N) fixation through legume-Rhizobium symbiosis is important for enhancing agricultural productivity and is therefore of great economic interest. Growing evidence indicates that other soil beneficial bacteria can positively affect symbiotic performance of rhizobia. Nodule endophytic plant growth promoting rhizobacteria (PGPR) were isolated from common bean nodules from Nakuru County in Kenya and characterized 16S rDNA partial gene sequencing. The effect of co-inoculation of rhizobium and PGPR, on nodulation and growth of common bean (Phaseolus vulgaris L...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28221699/beehive-fences-as-a-multidimensional-conflict-mitigation-tool-for-farmers-coexisting-with-elephants
#8
Lucy E King, Fredrick Lala, Hesron Nzumu, Emmanuel Mwambingu, Iain Douglas-Hamilton
Increasing habitat fragmentation and human population growth in Africa has resulted in an escalation in human-elephant conflict between small-scale farmers and free-ranging African elephants (Loxodonta Africana). In 2012 Kenya Wildlife Service (KWS) implemented the national 10-year Conservation and Management Strategy for the Elephant in Kenya, which includes an action aimed at testing whether beehive fences can be used to mitigate human-elephant conflict. From 2012 to 2015, we field-tested the efficacy of beehive fences to protect 10 0...
February 21, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28219991/impacts-on-global-health-from-nursing-research
#9
Kimberly Baltzell, Monica McLemore, Mona Shattell, Sally Rankin
Infectious disease continues to adversely affect populations in low- and middle-income countries. Investments in solutions often focus on technology, yet health-care workers remain in short supply. Nurses are the largest cadre of health-care workers and are largely responsible for patient care around the world. In fact, it is estimated that nurses care for nine out of every 10 patients seen. Importantly, sound nursing science contributes to solutions that directly impact patient care, especially, those that pertain to infectious disease...
February 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28219321/genetic-characterization-of-vibrio-cholerae-o1-isolates-from-outbreaks-between-2011-and-2015-in-tanzania
#10
Yazid Kachwamba, A A Mohammed, H Lukupulo, L Urio, M Majigo, F Mosha, M Matonya, R Kishimba, J Mghamba, J Lusekelo, S Nyanga, M Almeida, S Li, D Domman, S Y Massele, O C Stine
BACKGROUND: Cholera outbreaks have occurred in Tanzania since 1974. To date, the genetic epidemiology of these outbreaks has not been assessed. METHODS: 96 Vibrio cholerae O1 isolates from five regions were characterized, and their genetic relatedness assessed using multi-locus variable-number tandem-repeat analysis (MLVA) and whole genome sequencing (WGS). RESULTS: Of the 48 MLVA genotypes observed, 3 were genetically unrelated to any others, while the remaining 45 genotypes separated into three MLVA clonal complexes (CCs) - each comprised of genotypes differing by a single allelic change...
February 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28218698/genetic-assessment-of-african-swine-fever-isolates-involved-in-outbreaks-in-the-democratic-republic-of-congo-between-2005-and-2012-reveals-co-circulation-of-p72-genotypes-i-ix-and-xiv-including-19-variants
#11
Leopold K Mulumba-Mfumu, Jenna E Achenbach, Matthew R Mauldin, Linda K Dixon, Curé Georges Tshilenge, Etienne Thiry, Noelia Moreno, Esther Blanco, Claude Saegerman, Charles E Lamien, Adama Diallo
African swine fever (ASF) is a devastating disease of domestic pigs. It is a socioeconomically important disease, initially described from Kenya, but subsequently reported in most Sub-Saharan countries. ASF spread to Europe, South America and the Caribbean through multiple introductions which were initially eradicated-except for Sardinia-followed by re‑introduction into Europe in 2007. In this study of ASF within the Democratic Republic of the Congo, 62 domestic pig samples, collected between 2005-2012, were examined for viral DNA and sequencing at multiple loci: C-terminus of the B646L gene (p72 protein), central hypervariable region (CVR) of the B602L gene, and the E183L gene (p54 protein)...
February 18, 2017: Viruses
https://www.readbyqxmd.com/read/28217729/providing-palliative-care-to-patients-with-cancer-addressing-the-needs-in-kenya
#12
Pam Malloy, Juli Boit, Allison Tarus, Joyce Marete, Betty Ferrell, Zipporah Ali
Cancer is the third highest cause of death in Kenya, preceded by infectious and cardiovascular diseases, and in most cases, diagnosed in later stages. Nurses are the primary caregivers, assessing and managing these patients in the clinic, in inpatient settings, and in rural and remote communities. While cancer rates remain high, the burden to the patient, the caregiver, and society as a whole continues to rise. Kenya's poverty complicates cancer even further. Many Kenyans are unaware of cancer's signs and symptoms, and limited diagnostic and treatment centers are available...
January 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28217728/association-between-socioeconomic-and-psychological-experiences-of-parents-with-children-on-leukemia-treatment-in-kenyatta-national-hospital-kenya
#13
Roselyne Anyango Okumu, Margret Muiva, Miriam Wagoro, Fatmah Abdallah, Erick Oweya
OBJECTIVE: The survival rate for children with leukemia has increased dramatically since the late 1990s; treatment effects of the disease can be extremely stressful for families. Research on psychological and socioeconomic effects of leukemia treatment had been conducted in Western countries, but little is known within Africa including Kenya. METHODS: This was a cross-sectional study with a sample of 62 out of 72 parents of children undergoing leukemia treatment at Kenyatta National Hospital...
January 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28217723/cancer-nurses-in-africa-finding-their-footing
#14
EDITORIAL
David Makumi
David Makumi is an award-winning cancer control leader. The US Oncology Nursing Society. (ONS) awarded him the prestigious Distinguished Award for contribution to cancer care in 2011. The following year, the International Society of Nurses in Cancer Care presented him with the Past President Award for his work in designing low-cost models of increasing access to breast cancer screening. David is the East Africa Regional Cancer Programs Manager for the Aga Khan University Hospital. He has been involved in cancer advocacy on policy and legislation for over 10 years...
January 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28212643/vertical-hiv-transmission-in-perinatally-exposed-infants-in-south-rift-region-of-kenya-a-retrospective-cross-sectional-study
#15
Everline Ashiono, Dunstan Achwoka, Jamlick Mutugi, Joel Rakwar, Andrew Wafula, Otto Nzapfurundi Chabikuli
BACKGROUND: Despite proven efficacy of the prevention mother-to-child transmission of HIV strategy, its adoption in Africa has remained slow. In Kenya, its effectiveness remain unknown. The aim of this study was to assess the effectiveness of a prevention of mother-to-child transmission program in Kenya. METHODS: This retrospective cross-sectional study analyzed 2,642 records of HIV-exposed infants who had a deoxyribonucleic acid polymerase chain reaction test done...
February 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28212398/modelling-the-risk-of-taenia-solium-exposure-from-pork-produced-in-western-kenya
#16
Lian F Thomas, William A de Glanville, Elizabeth A J Cook, Barend M De C Bronsvoort, Ian Handel, Claire N Wamae, Samuel Kariuki, Eric M Fèvre
The tapeworm Taenia solium is the parasite responsible for neurocysticercosis, a neglected tropical disease of public health importance, thought to cause approximately 1/3 of epilepsy cases across endemic regions. The consumption of undercooked infected pork perpetuates the parasite's life-cycle through the establishment of adult tapeworm infections in the community. Reducing the risk associated with pork consumption in the developing world is therefore a public health priority. The aim of this study was to estimate the risk of any one pork meal in western Kenya containing a potentially infective T...
February 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28212379/distribution-and-abundance-of-key-vectors-of-rift-valley-fever-and-other-arboviruses-in-two-ecologically-distinct-counties-in-kenya
#17
Rosemary Sang, Samwel Arum, Edith Chepkorir, Gladys Mosomtai, Caroline Tigoi, Faith Sigei, Olivia Wesula Lwande, Tobias Landmann, Hippolyte Affognon, Clas Ahlm, Magnus Evander
BACKGROUND: Rift Valley fever (RVF) is a mosquito-borne viral zoonosis of ruminants and humans that causes outbreaks in Africa and the Arabian Peninsula with significant public health and economic consequences. Humans become infected through mosquito bites and contact with infected livestock. The virus is maintained between outbreaks through vertically infected eggs of the primary vectors of Aedes species which emerge following rains with extensive flooding. Infected female mosquitoes initiate transmission among nearby animals, which amplifies virus, thereby infecting more mosquitoes and moving the virus beyond the initial point of emergence...
February 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28209194/community-unit-performance-factors-associated-with-childhood-diarrhea-and-appropriate-treatment-in-nyanza-province-kenya
#18
Yoshito Kawakatsu, Junichi Tanaka, Kazuya Ogawa, Kenneth Ogendo, Sumihisa Honda
BACKGROUND: The government of Kenya launched its community health strategy in 2006 to improve certain aspects of its community health program. Under the strategy, community units (CUs) were established as level one of the Kenyan health system. A core member at this level is the community health worker (CHW). The objective of this study was to assess the relationship among the performance of the CUs, the prevalence of childhood diarrhea and appropriate treatment for it by controlling individual and community-level factors...
February 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28207516/economic-evaluation-of-mobile-phone-text-message-interventions-to-improve-adherence-to-hiv-therapy-in-kenya
#19
Anik R Patel, Jason Kessler, R Scott Braithwaite, Kimberly A Nucifora, Harsha Thirumurthy, Qinlian Zhou, Richard T Lester, Carlo A Marra
BACKGROUND: A surge in mobile phone availability has fueled low cost short messaging service (SMS) adherence interventions. Multiple systematic reviews have concluded that some SMS-based interventions are effective at improving antiretroviral therapy (ART) adherence, and they are hypothesized to improve retention in care. The objective of this study was to evaluate the cost-effectiveness of SMS-based adherence interventions and explore the added value of retention benefits. METHODS: We evaluated the cost-effectiveness of weekly SMS interventions compared to standard care among HIV+ individuals initiating ART for the first time in Kenya...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28207061/health-facility-challenges-to-the-provision-of-option-b-in-western-kenya-a-qualitative-study
#20
Anna Helova, Eliud Akama, Elizabeth A Bukusi, Pamela Musoke, Wafula Z Nalwa, Thomas A Odeny, Maricianah Onono, Sydney A Spangler, Janet M Turan, Iris Wanga, Lisa L Abuogi
No abstract text is available yet for this article.
March 1, 2017: Health Policy and Planning
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