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Neurocognition

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https://www.readbyqxmd.com/read/28550041/central-nervous-system-involvement-in-acute-lymphoblastic-leukemia-is-mediated-by-vascular-endothelial-growth-factor
#1
Vera Münch, Luca Trentin, Julia Herzig, Salih Demir, Felix Seyfried, Johann M Kraus, Hans A Kestler, Rolf Köhler, Thomas F E Barth, Geertruy Te Kronnie, Klaus-Michael Debatin, Lüder H Meyer
In acute lymphoblastic leukemia (ALL), central nervous system (CNS) involvement is a major clinical concern. Despite non-detectable CNS leukemia in many cases, prophylactic CNS-directed conventional intrathecal chemotherapy is required for relapse free survival indicating subclinical CNS manifestation in most patients. However, CNS-directed therapy is associated with long-term sequelae including neurocognitive deficits and secondary neoplasms. Therefore, molecular mechanisms and pathways mediating leukemia cell entry into the CNS need to be understood in order to identify targets for prophylactic and therapeutic interventions and develop alternative CNS-directed treatment strategies...
May 26, 2017: Blood
https://www.readbyqxmd.com/read/28550022/longitudinal-assessment-of-brain-derived-neurotrophic-factor-in-sardinian-psychotic-patients-labsp-a-protocol-for-a-prospective-observational-study
#2
Diego Primavera, Mirko Manchia, Luca Deriu, Massimo Tusconi, Roberto Collu, Maria Scherma, Paola Fadda, Walter Fratta, Bernardo Carpiniello
INTRODUCTION: Brain-derived neurotrophic factor (BDNF) plays a crucial role in neurodevelopment, synaptic plasticity and neuronal function and survival. Serum and plasma BDNF levels are moderately, but consistently, decreased in patients with schizophrenia (SCZ) compared with healthy controls. There is a lack of knowledge, however, on the temporal manifestation of this decline. Clinical, illness course and treatment factors might influence the variation of BDNF serum levels in patients with psychosis...
May 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28550021/effects-of-continuous-positive-airway-pressure-on-neurocognitive-architecture-and-function-in-patients-with-obstructive-sleep-apnoea-study-protocol-for-a-multicentre-randomised-controlled-trial
#3
Huajun Xu, Hui Wang, Jian Guan, Hongliang Yi, Yingjun Qian, Jianyin Zou, Yunyan Xia, Yiqun Fu, Xinyi Li, Xiao Jiao, Hengye Huang, Pin Dong, Ziwei Yu, Jun Yang, Mingliang Xiang, Jiping Li, Yanqing Chen, Peihua Wang, Yizhou Sun, Yuehua Li, Xiaojian Zheng, Wei Jia, Shankai Yin
OBJECTIVES: Many clinical studies have indicated that obstructive sleep apnoea (OSA), the most common chronic sleep disorder, may affect neurocognitive function, and that treatment for continuous positive airway pressure (CPAP) has some neurocognitive protective effects against the adverse effects of OSA. However, the effects of CPAP treatment on neurocognitive architecture and function remain unclear. Therefore, this multicentre trial was designed to investigate whether and when neurocognitive architecture and function in patients with OSA can be improved by CPAP treatment and to explore the role of gut microbiota in improving neurocognitive function during treatment...
May 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28549937/is-learning-episodic-memory-distinct-cognitive-and-neuroanatomic-correlates-of-immediate-recall-during-learning-trials-in-neurologically-normal-aging-and-neurodegenerative-cohorts
#4
K B Casaletto, G Marx, S Dutt, J Neuhaus, R Saloner, L Kritikos, B Miller, J H Kramer
Although commonly interpreted as a marker of episodic memory during neuropsychological exams, relatively little is known regarding the neurobehavior of "total learning" immediate recall scores. Medial temporal lobes are clearly associated with delayed recall performances, yet immediate recall may necessitate networks beyond traditional episodic memory. We aimed to operationalize cognitive and neuroanatomic correlates of total immediate recall in several aging syndromes. Demographically-matched neurologically normal adults (n=91), individuals with Alzheimer's disease (n=566), logopenic variant primary progressive aphasia (PPA) (n=34), behavioral variant frontotemporal dementia (n=97), semantic variant PPA (n=71), or nonfluent/agrammatic variant PPA (n=39) completed a neurocognitive battery, including the CVLT-Short Form trials 1-4 Total Immediate Recall; a majority subset also completed a brain MRI...
May 23, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28549269/high-hair-cortisol-concentrations-predict-worse-cognitive-outcome-after-stroke-results-from-the-tabasco-prospective-cohort-study
#5
E Ben Assayag, O Tene, A D Korczyn, L Shopin, E Auriel, J Molad, H Hallevi, C Kirschbaum, N M Bornstein, S Shenhar-Tsarfaty, E Kliper, T Stalder
BACKGROUND AND PURPOSE: The role of stress-related endocrine dysregulation in the development of cognitive changes following a stroke needs further elucidation. We explored this issue in a longitudinal study on stroke survivors using hair cortisol concentrations (HCC), a measure of integrated long-term cortisol levels. METHODS: Participants were consecutive cognitively intact first-ever mild-moderate ischemic stroke/transient ischemic attack (TIA) survivors from the Tel Aviv Brain Acute Stroke Cohort (TABASCO) study...
May 18, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28548462/neurocognitive-mechanisms-of-real-world-autobiographical-memory-retrieval-insights-from-studies-using-wearable-camera-technology
#6
REVIEW
Tiffany E Chow, Jesse Rissman
In recent years, investigation into the cognitive and neural mechanisms of autobiographical memory has been aided by the use of experimental paradigms incorporating wearable camera technology. By effortlessly capturing first-person images of one's life events, these cameras provide a rich set of naturalistic stimuli that can later be used to trigger the recall of specific episodes. Here, we chronicle the development and progression of such studies in behavioral and neuroimaging examinations of both clinical and nonclinical adult populations...
May 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28548461/attending-learning-and-socioeconomic-disadvantage-developmental-cognitive-and-social-neuroscience-of-resilience-and-vulnerability
#7
REVIEW
Kylie Schibli, Kyle Wong, Nina Hedayati, Amedeo D'Angiulli
We review current findings associating socioeconomic status (SES), development of neurocognitive functions, and neurobiological pathways. A sizeable interdisciplinary literature was organized through a bifurcated developmental trajectory (BiDeT) framework, an account of the external and internal variables associated with low SES that may lead to difficulties with attention and learning, along with buffers that may protect against negative outcomes. A consistent neurocognitive finding is that low-SES children attend to information nonselectively, and engage in late filtering out of task-irrelevant information...
May 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28547588/neurocognition-in-individuals-with-incidentally-identified-meningioma
#8
Alissa M Butts, Stephen Weigand, Paul D Brown, Ronald C Petersen, Clifford R Jack, Mary M Machulda, Jane H Cerhan
Meningiomas are primary intracranial tumors that are often asymptomatic. To our knowledge, no study has attempted to describe neurocognitive function in patients with incidentally-discovered meningioma. We utilized the Mayo Clinic Study of Aging (MCSA), which is a population-based sample of Olmsted County, Minnesota residents that includes neuropsychological testing and brain MRI approximately every 15 months. Using a text search of radiologists' notes of 2402 MCSA individuals (mean age 77 years, scanned between 2004 and 2014) we identified 48 eligible subjects (2%) who had at least one meningioma...
May 25, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28544954/long-term-attention-deficits-combined-with-subcortical-and-cortical-structural-central-nervous-system-alterations-in-young-adults-born-small-for-gestational-age
#9
Sabrina Suffren, Diego Angulo, Yang Ding, Pablo Reyes, Jorge Marin, Jose T Hernandez, Nathalie Charpak, Gregory A Lodygensky
BACKGROUND: Being born small for gestational age has been associated with neurodevelopmental disabilities and smaller gray matter volumes in childhood. However, it is not known if these changes persist in adults and whether SGA has any impact on attention memory and IQ. AIMS: The goal of this study was to evaluate the association between birth weight and gray matter anatomy in adults born small for gestational age at term, in relation to IQ, attention and memory...
May 22, 2017: Early Human Development
https://www.readbyqxmd.com/read/28544904/decreased-prefrontal-functional-brain-response-during-memory-testing-in-women-with-cushing-s-syndrome-in-remission
#10
Oskar Ragnarsson, Andreas Stomby, Per Dahlqvist, Johan A Evang, Mats Ryberg, Tommy Olsson, Jens Bollerslev, Lars Nyberg, Gudmundur Johannsson
Neurocognitive dysfunction is an important feature of Cushing's syndrome (CS). Our hypothesis was that patients with CS in remission have decreased functional brain responses in the prefrontal cortex and hippocampus during memory testing. In this cross-sectional study we included 19 women previously treated for CS and 19 controls matched for age, gender, and education. The median remission time was 7 (IQR 6-10) years. Brain activity was studied with functional magnetic resonance imaging during episodic- and working-memory tasks...
May 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28544538/cornelia-de-lange-syndrome-to-diagnose-or-not-to-diagnose-in-utero
#11
REVIEW
Laura Avagliano, Gaetano Pietro Bulfamante, Valentina Massa
Cornelia de Lange syndrome (CdLS) is an inherited condition with a wide spectrum of phenotypic anomalies, consisting mainly of growth impairment, multi-organ abnormalities, and neurocognitive delay. Clinical diagnostic criteria after birth are well defined, whereas when to suspect the syndrome during intrauterine life still remains undefined. This review summarizes the main possible prenatal findings in CdLS, suggesting that a skilled ultrasound scan in cases of intrauterine growth restriction associated with other fetal abnormalities may improve the chance of prenatal diagnosis of CdLS, especially in families known to be at high risk...
May 22, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28544009/a-cluster-randomised-controlled-trial-evaluating-the-effects-of-delaying-onset-of-adolescent-substance-abuse-on-cognitive-development-and-addiction-following-a-selective-personality-targeted-intervention-program-the-co-venture-trial
#12
Maeve O'Leary-Barrett, Benoit Mâsse, Robert Pihl, Sherry Stewart, Jean R Séguin, Patricia Conrod
AIMS: Substance use and binge drinking during early adolescence are associated with neurocognitive abnormalities, mental health problems and an increased risk for future addiction. The trial aims to evaluate the protective effects of an evidence-based substance use prevention program on the onset of alcohol and drug use in adolescence, as well as on cognitive, mental health and addiction outcomes over 5 years. DESIGN: Thirty-eight high schools will be recruited, with a final sample of 31 schools assigned to intervention or control conditions (approximately 3800 youth)...
May 21, 2017: Addiction
https://www.readbyqxmd.com/read/28543773/degradation-of-heme-oxygenase-1-by-the-immunoproteasome-in-astrocytes-a-potential-interferon-%C3%AE-dependent-mechanism-contributing-to-hiv-neuropathogenesis
#13
Colleen E Kovacsics, Alexander J Gill, Surendra S Ambegaokar, Benjamin B Gelman, Dennis L Kolson
Induction of the detoxifying enzyme heme oxygenase-1 (HO-1) is a critical protective host response to cellular injury associated with inflammation and oxidative stress. We previously found that HO-1 protein expression is reduced in brains of HIV-infected individuals with HIV-associated neurocognitive disorders (HAND) and in HIV-infected macrophages, where this reduction associates with enhanced glutamate release and neurotoxicity. Because HIV-infected macrophages are a small component of the cellular content of the brain, the reduction of macrophage HO-1 expression likely accounts for a small portion of brain HO-1 loss in HIV infection...
May 22, 2017: Glia
https://www.readbyqxmd.com/read/28541578/disrupted-development-and-integrity-of-frontal-white-matter-in-patients-treated-for-pediatric-medulloblastoma
#14
John O Glass, Robert J Ogg, Jung W Hyun, Julie H Harreld, Jane E Schreiber, Yimei Li, Amar J Gajjar, Wilburn E Reddick
Background.: Treatment of pediatric medulloblastoma is associated with known neurocognitive deficits that we hypothesize are caused by microstructural damage to frontal white matter (WM). Methods.: Longitudinal MRI examinations were collected from baseline (after surgery but before therapy) to 36 months in 146 patients and at 3 time points in 72 controls. Regional analyses of frontal WM volume and diffusion tensor imaging metrics were performed and verified with tract-based spatial statistics...
May 25, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28541413/the-influence-of-the-apolipoprotein-e-apoe-gene-on-subacute-post-concussion-neurocognitive-performance-in-college-athletes
#15
Victoria C Merritt, Amanda R Rabinowitz, Peter A Arnett
Objective: The purpose of this study was to determine whether the ε4 allele of the APOE gene influences neurocognitive outcome following sports-related concussion. It was hypothesized that participants with an ε4 allele would show poorer neurocognitive performance and greater neurocognitive variability than those without an ε4 allele. Method: Participants included 57 concussed collegiate athletes (77.2% male) who participated in a concussion management program at a large university...
May 24, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28541386/factor-structure-and-measurement-invariance-of-the-coimbra-neuropsychological-assessment-battery-banc
#16
Octávio Moura, Cristina P Albuquerque, Maria Salomé Pinho, Manuela Vilar, Ana Filipa Lopes, Isabel Alberto, Marcelino Pereira, Maria João Seabra Santos, Mário R Simões
Objective: This study aimed to investigate the factor structure of the Coimbra Neuropsychological Assessment Battery (BANC), which is an individually administered battery designed to assess a wide range of neurocognitive functions in children. Method: Using the standardization sample of the BANC, a confirmatory factor analysis and a multiple-group analysis were conducted to examine the factor structure and the measurement invariance of three main domains (Memory, Language, and Attention/Executive Functions) in 833 children aged 7-15 years...
May 25, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28541084/the-feasibility-of-automated-eye-tracking-with-the-early-childhood-vigilance-test-of-attention-in-younger-hiv-exposed-ugandan-children
#17
Michael J Boivin, Jonathan Weiss, Ronak Chhaya, Victoria Seffren, Jorem Awadu, Alla Sikorskii, Bruno Giordani
OBJECTIVE: Tobii eye tracking was compared with webcam-based observer scoring on an animation viewing measure of attention (Early Childhood Vigilance Test; ECVT) to evaluate the feasibility of automating measurement and scoring. Outcomes from both scoring approaches were compared with the Mullen Scales of Early Learning (MSEL), Color-Object Association Test (COAT), and Behavior Rating Inventory of Executive Function for preschool children (BRIEF-P). METHOD: A total of 44 children 44 to 65 months of age were evaluated with the ECVT, COAT, MSEL, and BRIEF-P...
May 25, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28540667/neurocognitive-functioning-in-pediatric-craniopharyngioma-performance-before-treatment-with-proton-therapy
#18
Ashley S Fournier-Goodnight, Jason M Ashford, Thomas E Merchant, Frederick A Boop, Daniel J Indelicato, Lei Wang, Hui Zhang, Heather M Conklin
The goal of this study was to investigate the impact of patient-, disease-, and treatment-related variables upon neurocognitive outcomes in pediatric patients with craniopharyngioma prior to treatment with proton therapy or observation after radical resection. For all participants (N = 104), relevant clinical and demographic variables were attained and neurocognitive evaluations completed prior to irradiation or planned observation. One-sample t-tests were conducted to compare performance to published normative data...
May 24, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28538982/association-of-late-adolescent-personality-with-risk-for-subsequent-serious-mental-illness-among-men-in-a-swedish-nationwide-cohort-study
#19
Joseph F Hayes, David P J Osborn, Glyn Lewis, Christina Dalman, Andreas Lundin
Importance: Understanding of personality as an independent risk factor for serious mental illness (SMI) remains limited. Recently, overlap between the polygenic basis for specific personality traits and specific SMIs has been identified. Objective: To determine the association of the adolescent personality domains of social maturity, mental energy, and emotional stability with later diagnosis of SMI. Design, Setting, and Participants: This longitudinal cohort study enrolled Swedish male military conscripts aged 18 or 19 years from January 1, 1974, through December 31, 1997...
May 24, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28537651/the-burden-of-hiv-associated-neurocognitive-disorder-hand-in-post-haart-era-a-multidisciplinary-review-of-the-literature
#20
G Caruana, G Vidili, P A Serra, P Bagella, A Spanu, V Fiore, D F Calvisi, R Manetti, G Rocchitta, S Nuvoli, S Babudieri, M M Simile, G Madeddu
OBJECTIVE: The purpose of the present multidisciplinary review is to give an updated insight into the most recent findings regarding the pathophysiology, diagnosis and therapeutics of HIV-associated neurocognitive disorder (HAND). MATERIALS AND METHODS: We performed a comprehensive search, through electronic databases (Pubmed - MEDLINE) and search engines (Google Scholar), of peer-reviewed publications (articles and reviews) and conferences proceedings on HAND pathophysiology, diagnosis, and therapy, from 1999 to 2016...
May 2017: European Review for Medical and Pharmacological Sciences
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