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https://www.readbyqxmd.com/read/28732160/color-encoded-assays-for-the-simultaneous-quantification-of-dual-cancer-biomarkers
#1
Jun Ma, Lei Zhan, Rong Sheng Li, Peng Fei Gao, Cheng Zhi Huang
For the first time, the scattering light of noble nanoparticles was applied for the simultaneous detection of dual cancer biomarkers. Two nanoprobes with dual scattering light colors were used for the simultaneous imaging of alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) based on the sandwich-type immunoassay. Since AFP can combine anti-AFP-modified gold nanoparticles which have green scattering light under dark-field microscopic imaging (iDFM) technique while CEA can conjugate anti-CEA-immobilized silver nanoparticles which have blue scattering light, the simultaneous determination of AFP and CEA can be achieved by separately counting the number of green and blue light spots in iDFM technique...
July 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28731391/malpractice-litigation-following-spine-surgery
#2
Alan H Daniels, Roy Ruttiman, Adam E M Eltorai, J Mason DePasse, Bielinsky A Brea, Mark A Palumbo
OBJECTIVE Adverse events related to spine surgery sometimes lead to litigation. Few studies have evaluated the association between spine surgical complications and medical malpractice proceedings, outcomes, and awards. The aim of this study was to identify the most frequent causes of alleged malpractice in spine surgery and to gain insight into patient demographic and clinical characteristics associated with medical negligence litigation. METHODS A search for "spine surgery" spanning February 1988 to May 2015 was conducted utilizing the medicolegal research service VerdictSearch (ALM Media Properties, LLC)...
July 21, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28726169/comparison-of-the-systemic-and-local-pharmacokinetics-of-clonidine-mucoadhesive-buccal-tablets-with-reference-clonidine-oral-tablets-in-healthy-volunteers-an-open-label-randomised-cross-over-trial
#3
Bérangère Vasseur, Alain Dufour, Laetitia Houdas, Helen Goodwin, Kathryn Harries, Neslihan Yesiltas Emul, Simon Hutchings
INTRODUCTION: The clonidine mucoadhesive buccal tablet (MBT) is a novel delivery system resulting in high and sustained concentrations of clonidine in the oral cavity. In a phase II clinical trial, clonidine MBT reduced the incidence of severe oral mucositis (OM) compared to placebo in head and neck cancer patients undergoing chemoradiation. This study compared the pharmacokinetics (PK), safety and tolerability of clonidine MBT with a reference oral tablet (OT). METHODS: This was a randomised, three-period, single-dose crossover study in 36 healthy subjects aged 18-50 years...
July 19, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28720558/my-team-of-care-study-a-pilot-randomized-controlled-trial-of-a-web-based-communication-tool-for-collaborative-care-in-patients-with-advanced-cancer
#4
Teja Voruganti, Eva Grunfeld, Trevor Jamieson, Allison M Kurahashi, Bhadra Lokuge, Monika K Krzyzanowska, Muhammad Mamdani, Rahim Moineddin, Amna Husain
BACKGROUND: The management of patients with complex care needs requires the expertise of health care providers from multiple settings and specialties. As such, there is a need for cross-setting, cross-disciplinary solutions that address deficits in communication and continuity of care. We have developed a Web-based tool for clinical collaboration, called Loop, which assembles the patient and care team in a virtual space for the purpose of facilitating communication around care management...
July 18, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28720052/the-effectiveness-of-various-interventions-versus-standard-stripping-in-patients-with-varicose-veins-in-terms-of-quality-of-life
#5
Christos Argyriou, Christos Papasideris, George A Antoniou, Efstratios Georgakarakos, Nikolaos Papanas, Miltos K Lazarides, George S Georgiadis
Purpose Lower limb varicose veins have a significant effect upon the quality of life and a considerable socioeconomic impact despite their relatively benign nature. The aim of this study is to compare the effects of various therapeutic strategies among patients with varicose veins to surgical ligation and vein stripping on the basis of quality of life. Methods PubMed/Medline and Scopus databases were systemically searched from 1 January 2000 until 23 December 2015 for studies reporting outcome on the quality of life of different treatment techniques for varicose veins...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28719766/energy-expenditure-of-standing-compared-to-sitting-while-conducting-office-tasks
#6
Jill Burns, Cuisle Forde, Sara Dockrell
Objectives This study aimed to investigate the energy expenditure of common office-based tasks. The objectives were to: (a) test the classification of tasks as sedentary or light-intensity physical activity and (b) compare the energy expenditure of tasks under two postural conditions (sitting and standing). Background The sedentary nature of office work has been highlighted as a health risk, and strategies to reduce sedentary behavior at work have been developed. However, there is limited evidence to guide the utilization of sit-stand workstations in the workplace for metabolic health benefits...
July 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28718516/control-of-the-fluid-viscosity-in-a-mock-circulation
#7
Stefan Boës, Gregor Ochsner, Raffael Amacher, Anastasios Petrou, Mirko Meboldt, Marianne Schmid Daners
A mock circulation allows the in vitro investigation, development, and testing of ventricular assist devices. An aqueous-glycerol solution is commonly used to mimic the viscosity of blood. Due to evaporation and temperature changes, the viscosity of the solution drifts from its initial value and therefore, deviates substantially from the targeted viscosity of blood. Additionally, the solution needs to be exchanged to account for changing viscosities when mimicking different hematocrits. This article presents a method to control the viscosity in a mock circulation...
July 17, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28718236/dose-comparison-and-side-effect-profile-of-metformin-extended-release-versus-metformin-immediate-release
#8
Maliha Hameed, Khurshid Khan, Sadia Salman, Nasir Mehmood
BACKGROUND: Diabetes Mellitus type 2 is very common worldwide, with majority of cases in Asia Pacific region. Metformin is the first line therapy, along with lifestyle modification for all type 2 diabetics as recommended by ADA. Metformin is available as conventional Metformin Immediate Release (MIR) and Metformin Extended Release (MXR). Metformin XR has better gastrointestinal tolerability and fewer side effects as compared to Metformin IR, with similar efficacy regarding anti-hyperglycaemic effects...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28716051/mir-380-5p-mediated-repression-of-tep1-and-tspyl5-interferes-with-telomerase-activity-and-favours-the-emergence-of-an-alt-like-phenotype-in-diffuse-malignant-peritoneal-mesothelioma-cells
#9
Graziella Cimino-Reale, Paolo Gandellini, Francesca Santambrogio, Marta Recagni, Nadia Zaffaroni, Marco Folini
BACKGROUND: Understanding the molecular/cellular underpinnings of diffuse malignant peritoneal mesothelioma (DMPM), a fatal malignancy with limited therapeutic options, is of utmost importance for the fruitful management of the disease. In this context, we previously found that telomerase activity (TA), which accounts for the limitless proliferative potential of cancer cells, is prognostic for disease relapse and cancer-related death in DMPM patients. Consequently, the identification of factors involved in telomerase activation/regulation may pave the way towards the development of novel therapeutic interventions for the disease...
July 17, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28710970/validation-of-a-probe-for-assessing-deconjugation-of-glucuronide-and-sulfate-phase-ii-metabolites-assayed-through-lc-ms-ms-in-biological-matrices
#10
Claire Grignon, Antoine Dupuis, Marion Albouy-Llaty, Maxime Condylis, Laurence Barrier, Pascal Carato, Bertrand Brunet, Virginie Migeot, Nicolas Venisse
LC-MS/MS has been proposed in various areas such as Therapeutic Drug Monitoring (TDM), Human Biomonitoring (HBM), disease diagnosis, clinical toxicology and doping control to identify and quantify chemical parents and their metabolites in biological matrices. To determine the total content of a xenobiotic (unconjugated+conjugated forms), an enzymatic hydrolysis step is required. Most studies in the literature have not controlled the effectiveness of the deconjugation process because no method has been described for that purpose...
July 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28709661/left-sided-reoperations-after-arterial-switch-operation-a-european-multicenter-study
#11
Vladimiro L Vida, Lorenza Zanotto, Lucia Zanotto, Giovanni Stellin, Massimo Padalino, Georges Sarris, Eleftherios Protopapas, Carol Prospero, Christian Pizarro, Edward Woodford, Thomas Tlaskal, Hakan Berggren, Martin Kostolny, Ikenna Omeje, Boulos Asfour, Alexander Kadner, Thierry Carrel, Paul H Schoof, Matej Nosal, Josè Fragata, Michał Kozłowski, Bohdan Maruszewski, Luca A Vricella, Duke E Cameron, Vladimir Sojak, Mark Hazekamp, Jukka Salminen, Ilkka P Mattila, Julie Cleuziou, Patrick O Myers, Viktor Hraska
BACKGROUND: We sought to report the frequency, types, and outcomes of left-sided reoperations (LSRs) after an arterial switch operation (ASO) for patients with D-transposition of the great arteries (D-TGA) and double-outlet right ventricle (DORV) TGA-type. METHODS: Seventeen centers belonging to the European Congenital Heart Surgeons Association (ECHSA) contributed to data collection. We included 111 patients who underwent LSRs after 7,951 ASOs (1.4%) between January 1975 and December 2010...
July 11, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28707817/evaluation-of-free-or-anchored-antimicrobial-peptides-as-candidates-for-the-prevention-of-orthopaedic-device-related-infections
#12
Francesca D'Este, Debora Oro, Gerard Boix-Lemonche, Alessandro Tossi, Barbara Skerlavaj
The prevention of implant-associated infection, one the most feared complications in orthopaedic surgery, remains a major clinical challenge and urges development of effective methods to prevent bacterial colonization of implanted devices. Alpha-helical antimicrobial peptides (AMPs) may be promising candidates in this respect due to their potent and broad-spectrum antimicrobial activity, their low tendency to elicit resistance and possible retention of efficacy in the immobilized state. The aim of this study was to evaluate the potential of five different helical AMPs, the cathelicidins BMAP-27 and BMAP-28, their (1-18) fragments and the rationally designed, artificial P19(9/G7) peptide, for the prevention of orthopaedic implant infections...
July 14, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28703105/bronchial-artery-embolization-in-hemoptysis-a-systematic-review
#13
Ananya Panda, Ashu Seith Bhalla, Ankur Goyal
We systematically reviewed the role of bronchial artery embolization (BAE) in hemoptysis. Literature search was done for studies on BAE published between 1976 and 2016. Twenty-two studies published in English, with sample size of at least 50 patients, reporting indications, technique, efficacy, and follow-up were included in the final analysis. Common indications for BAE included tuberculosis (TB), post-tubercular sequelae, bronchiectasis, and aspergillomas. Most common embolizing agent used was polyvinyl alcohol (size, 300-600 μm) with increasing use of glue in recent years...
July 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28696372/warfarin-and-flavonoids-do-not-share-the-same-binding-region-in-binding-to-the-iia-subdomain-of-human-serum-albumin
#14
Hrvoje Rimac, Claire Dufour, Željko Debeljak, Branka Zorc, Mirza Bojić
Human serum albumin (HSA) binds a variety of xenobiotics, including flavonoids and warfarin. The binding of another ligand to the IIA binding site on HSA can cause warfarin displacement and potentially the elevation of its free concentration in blood. Studies dealing with flavonoid-induced warfarin displacement from HSA provided controversial results: estimated risk of displacement ranged from none to serious. To resolve these controversies, in vitro study of simultaneous binding of warfarin and eight different flavonoid aglycons and glycosides to HSA was carried out by fluorescence spectroscopy as well as molecular docking...
July 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28696089/prevention-of-sudden-cardiac-death-from-wearable-to-subcutaneous-cardioverter-defibrillator
#15
Stefano Viani, Ezio Soldati, Andrea DI Cori, Luca Segreti, Luca Paperini, Raffaele DE Lucia, Giulio Zucchelli, Maria G Bongiorni
The implantable cardioverter defibrillator (ICD) is today an indisputable evidence-based treatment for cardiac sudden death both in primary and secondary prevention. However many clinical conditions that would represent an indication to ICD implantation, according to guidelines, may be potentially reversible or may be accompanied by temporary contraindications to the implant. Moreover transvenous cardioverter defibrillator implantation still carries a not negligible risk of complications both acutely and at follow-up...
July 10, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28692857/modelling-and-extraction-of-pulsatile-radial-distension-and-compression-motion-for-automatic-vessel-segmentation-from-video
#16
Alborz Amir-Khalili, Ghassan Hamarneh, Rafeef Abugharbieh
Identification of vascular structures from medical images is integral to many clinical procedures. Most vessel segmentation techniques ignore the characteristic pulsatile motion of vessels in their formulation. In a recent effort to automatically segment vessels that are hidden under fat, we motivated the use of the magnitude of local pulsatile motion extracted from surgical endoscopic video. In this article we propose a new approach that leverages the local orientation, in addition to magnitude of motion, and demonstrate that the extended computation and utilization of motion vectors can improve the segmentation of vascular structures...
June 29, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28691361/impact-of-childhood-trauma-on-cognitive-profile-in-bipolar-disorder
#17
Esther Jiménez, Brisa Solé, Bárbara Arias, Marina Mitjans, Cristina Varo, María Reinares, Caterina Del Mar Bonnín, Victoria Ruíz, Pilar Alejandra Saiz, M Paz García-Portilla, Patricia Burón, Julio Bobes, Benedikt L Amann, Anabel Martínez-Arán, Carla Torrent, Eduard Vieta, Antoni Benabarre
OBJECTIVES: Bipolar Disorder (BD) is associated with cognitive impairment even during remission periods. Nonetheless, this impairment seems to adjust to different profiles of severity. Our aim was to examine the potential impact of childhood trauma (CT) on cognitive performance and, more specifically, on neurocognitive profile membership. METHODS: Using a data-driven strategy, 113 euthymic bipolar patients were grouped according to their cognitive performance using a hierarchical clustering technique...
July 10, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28691164/pick-s-disease-with-neuronal-four-repeat-tau-accumulation-in-the-basal-ganglia-brain-stem-nuclei-and-cerebellum
#18
Chikako Ikeda, Osamu Yokota, Tomoko Miki, Shintaro Takenoshita, Hideki Ishizu, Yoko Mori, Kiyohiro Yamazaki, Yuki Ozaki, Shu-Ichi Ueno, Takeshi Ishihara, Masato Hasegawa, Seishi Terada, Norihito Yamada
It is very rare that cases of Pick's disease, a representative three-repeat (3R) tauopathy, also have significant four-repeat (4R) tau accumulation. Here, we report a Pick's disease case that clinically showed behavioral variant frontotemporal dementia without motor disturbance during the course, and pathologically had 3R tau-positive Pick bodies as well as numerous 4R tau-positive neuronal cytoplasmic inclusions (NCIs). Abundant 3R tau-positive 4R tau-negative spherical or horseshoe-shaped Pick bodies were found in the frontotemporal cortex, limbic region, striatum and pontine nucleus...
July 9, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28688120/electron-beam-water-calorimetry-measurements-to-obtain-beam-quality-conversion-factors
#19
Bryan R Muir, Claudiu D Cojocaru, Malcolm R McEwen, Carl K Ross
PURPOSE: To provide results of water calorimetry and ion chamber measurements in high-energy electron beams carried out at the National Research Council Canada (NRC). There are three main aspects to this work: 1) investigation of the behavior of ionization chambers in electron beams of different energies with focus on long-term stability, 2) water calorimetry measurements to determine absorbed dose to water in high-energy beams for direct calibration of ion chambers, and 3) using measurements of chamber response relative to reference ion chambers, determination of beam quality conversion factors, kQ, for several ion chamber types...
July 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28686273/photosensitizer-ps-polyhedral-oligomeric-silsesquioxane-poss-crosslinked-nanohybrids-for-enhanced-imaging-guided-photodynamic-cancer-therapy
#20
Ya-Xuan Zhu, Hao-Ran Jia, Zhan Chen, Fu-Gen Wu
Photodynamic therapy (PDT) has drawn extensive attention as a promising cancer treatment modality. However, most PDT nanoagents suffer from insufficient drug loading capacity, a severe self-quenching effect, premature release of drugs and/or potential toxicity. Herein, we rationally designed an inorganic-organic nanohybrid with high drug loading capacity and superior chemical stability for enhanced PDT. Polyhedral oligomeric silsesquioxane (POSS), an amine-containing cage-shaped building block, was crosslinked with chlorin e6 (Ce6), a carboxyl-containing photosensitizer, via the amine-carboxyl reaction...
July 7, 2017: Nanoscale
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