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https://www.readbyqxmd.com/read/29216739/lymphatic-drainage-efficiency-a-new-parameter-of-lymphatic-function
#1
Georgia Keramida, Emma Wroe, Nicola Winterman, Mark Aplin, A Michael Peters
Background Following convection from blood capillaries, plasma proteins are transported to loco-regional lymph nodes in two stages: first, uptake into peripheral lymphatics, and second, transport to nodes. Purpose To introduce a new parameter of lymphatic function that quantifies stage 2 - lymphatic drainage efficiency (LDE). Material and Methods Percentage injected activity (IIQ) in ilio-inguinal nodes 150 min following subcutaneous foot web-space injection of Tc-99 m-nanocolloid was measured in 102 patients undergoing lymphoscintigraphy using a method in which a standard is placed by image guidance over the nodes...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29214652/pharmacology-in-translation-the-preclinical-and-early-clinical-profile-of-the-novel-%C3%AE-2-3-functionally-selective-gabaa-receptor-positive-allosteric-modulator-pf-06372865
#2
Sarah A Nickolls, Rachel Gurrell, Guido van Amerongen, Juha Kammonen, Lishuang Cao, Adam R Brown, Clara Stead, Andy Mead, Christine Watson, Cathleen Hsu, Robert M Owen, Andy Pike, Rebecca L Fish, Laigao Chen, Ruolun Qiu, Evan D Morris, Gang Feng, Mark Whitlock, Donal Gorman, Joop van Gerven, David S Reynolds, Pinky Dua, Richard P Butt
BACKGROUND AND PURPOSE: Benzodiazepines (BZDs), non-selective positive allosteric modulators (PAMs) of GABAA receptors, have significant side-effects that limit their clinical utility. As many of these side-effects are mediated by the α1 subunit there has been a concerted effort to develop α2/3 subtype-selective PAMs. EXPERIMENTAL APPROACH: In vitro screening assays were used to identify molecules with functional selectivity for receptors containing α2/3 subunits over those containing α1 subunits...
December 7, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29210372/melanin-manganese-nanoparticles-with-ultrahigh-efficient-clearance-in-vivo-for-tumor-targeting-t1-magnetic-resonance-imaging-contrast-agent
#3
Wen Xu, Jinghua Sun, Liping Li, Xiaoyang Peng, Ruiping Zhang, Binquan Wang
Endogenous biomaterials in organisms, with native biocompatibility and biodegradability, appear more advantageous in the development of nanoscale diagnostic and therapeutic systems for future clinical translation. Herein, a novel tumor-targeting Magnetic Resonance Imaging (MRI) contrast agent was developed based on Mn2+-chelating ultrasmall water-soluble melanin nanoparticles (MNP-PEG-Mn). The nanoparticles, with a size of about 5.6 nm, presented high chelation stability and showed negligible cytotoxicity as estimated by MTT assay...
December 6, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29210330/subcutaneous-local-anesthetic-infusion-could-eliminate-use-of-epidural-analgesia-after-the-nuss-procedure
#4
Sandra K Kabagambe, Laura F Goodman, Y Julia Chen, Benjamin A Keller, James C Becker, Gary W Raff, Rebecca A Stark, Jacob T Stephenson, Amy Rahm, Diana L Farmer, Shinjiro Hirose
AIM: To compare outcomes of continuous subcutaneous infusion of local anesthetic and epidural analgesia following the Nuss procedure. PATIENTS & METHODS: A retrospective chart review compared patients managed with subcutaneous local anesthetic infusion (n = 12) versus thoracic epidural (n = 19) following the Nuss procedure from March 2013 to June 2015. RESULTS: There was no difference in hospital length of stay or days on intravenous narcotics...
December 6, 2017: Pain Management
https://www.readbyqxmd.com/read/29208360/the-influence-of-soluble-fragments-of-extracellular-matrix-ecm-on-tumor-growth-and-morphology
#5
Nurun N Nargis, Ralph C Aldredge, Robert D Guy
A major challenge in matrix-metalloproteinase (MMP) target validation and MMP-inhibitor-drug development for anti-cancer clinical trials is to better understand their complex roles (often competing with each other) in tumor progression. While there is extensive research on the growth-promoting effects of MMPs, the growth-inhibiting effects of MMPs has not been investigated thoroughly. So we develop a continuum model of tumor growth and invasion including chemotaxis and haptotaxis in order to examine the complex interaction between the tumor and its host microenvironment and to explore the inhibiting influence of the gradients of soluble fragments of extracellular matrix (ECM) density on tumor growth and morphology...
December 2, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/29206792/direct-anterior-hip-replacement-does-not-pose-undue-radiation-exposure-risk-to-the-patient-or-surgeon
#6
David Clinton McNabb, Jason M Jennings, Daniel L Levy, Todd M Miner, Charlie C Yang, Raymond H Kim
BACKGROUND: The fluoroscopically assisted direct anterior approach for total hip arthroplasty has gained interest in recent years. One of the perceived advantages is the use of fluoroscopy to aid in the positioning of implants. The purpose of this study was to measure the radiation entrance surface dose to anatomically important areas of both patients and surgeons during direct anterior approach total hip arthroplasty. METHODS: Radiation dosimetry badges were placed at the sternal notch and pubic symphysis of 50 patients undergoing direct anterior approach total hip arthroplasty...
December 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29205165/prevalence-of-antibiotic-resistance-in-fecal-flora-before-transrectal-ultrasound-guided-prostate-biopsy-and-the-clinical-impact-of-targeted-antibiotic-prophylaxis
#7
Arikan Ozgur, Yildirim Asif, Atis Gokhan, Tanidir Berrin, Gurbuz Cenk, Erol Bulent, Danacioglu Onur, Culpan Meftun, Vahapoglu Haluk, Caskurlu Hulya, Caskurlu Turhan
OBJECTIVES: In this study, we aimed to evaluate ciprofloxacin resistance and the presence of extended-spectrum beta-lactamase producing organisms (ESBLs) in the population of patients with indication to undergo prostate biopsy. Our additional aim was to compare the targeted antibiotic prophylaxis and sepsis rates after transrectal ultrasound guided prostate biopsy in patients who received routine ciprofloxacin prophylaxis and to evaluate the predictive factors of antibiotic resistance...
December 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29204573/protective-and-antifungal-properties-of-nanodisk-amphotericin-b-over-commercially-available-amphotericin-b
#8
Do-Yeon Cho, Kyle J Hoffman, Gobind S Gill, Dong-Jin Lim, Daniel Skinner, Calvin Mackey, Steven M Rowe, Bradford A Woodworth
Objective: Amphotericin B (AMB), a potent antifungal agent, has been employed as topical and systemic therapy for sinonasal fungal infections. A novel formulation of nanodisc (ND) containing super aggregated AMB (ND-AMB) for the treatment of fungal infections has been recently developed to provide greater protection from AMB toxicity than current, clinically approved lipid-based formulations. The objective of the current study was to evaluate the safety and potency of ND-AMB for sinonasal delivery using an in vitro model...
March 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29201863/predictive-assessment-of-cancer-center-catchment-area-from-electronic-health-records
#9
Luca Salmasi, Enrico Capobianco
Healthcare facilities (HF) may identify catchment areas (CA) by selecting criteria that depend on various factors. These refer to hospital activities, geographical definition, patient covariates, and more. The analyses that were traditionally pursued have a limiting factor in the consideration of only static conditions. Instead, some of the CA determinants involve influences occurring at both temporal and spatial scales. The study of CA in the cancer context means choosing between HF, usually divided into general hospitals versus oncological centers (OCs)...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29200717/in-vitro-and-in-vivo-activity-of-myrsine-africana-on-elastase-inhibition-and-anti-wrinkle-activity
#10
Namrita Lall, Navneet Kishore, Bianca Fibrich, Isa Anina Lambrechts
Background: Myrsine africana (MA) is a plant traditionally used in South Africa to treat various diseases. Objective: The ethanolic extract of MA, was used for in vitro and in vivo studies to determine its elastase inhibitory activity. Materials and Methods: MA and its isolated compound, myrsinoside B, were tested in vitro for their elastase inhibitory activity. The MA extract was also evaluated for mutagenicity using two strains of Salmonella typhimurium (TA 98 and TA 100), microbial count, metal analysis, and stability...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29199891/immune-response-of-bovine-sourced-cross-linked-collagen-sponge-for-hemostasis
#11
Lin Zhang, Xufeng Niu, Lei Sun, Zhending She, Rongwei Tan, Wei Wang
A comprehensive immunogenicity scheme is proposed to examine immune response of bovine sourced hemostasis collagen sponge to establish foundation for further researches and decrease the incidence of adverse reaction in clinical trials. Compared with negative control group without any implant, spleen and lymph nodes morphology show no apparent swelling in mice with different doses of collagen sponge implants. Immune cells population, especially lymph nodes cells population, is practically coincident with organs...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29198892/rtb-lectin-mediated-delivery-of-lysosomal-%C3%AE-l-iduronidase-mitigates-disease-manifestations-systemically-including-the-central-nervous-system
#12
Li Ou, Michael J Przybilla, Brenda Koniar, Chester B Whitley
Mucopolysaccharidosis type I (MPS I) is a lysosomal disease resulting from deficiency in the α-L-iduronidase (IDUA) hydrolase and subsequent accumulation of glycosaminoglycan (GAG). Clinically, enzyme replacement therapy (ERT) with IDUA achieves negligible neurological benefits presumably due to blood-brain-barrier (BBB) limitations. To investigate the plant lectin ricin B chain (RTB) as a novel carrier for enzyme delivery to the brain, an IDUA:RTB fusion protein (IDUAL), produced in N. benthamiana leaves, was tested in a murine model of Hurler syndrome (MPS I)...
November 28, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29198043/the-diagnosis-of-dementias-a-practical-tool-not-to-miss-rare-causes
#13
Camilla Ferrari, Benedetta Nacmias, Sandro Sorbi
Dementia represents one of the most diffuse disorders of our Era. Alzheimer's disease is the principle cause of dementia worldwide. Metabolic, infectious, autoimmune, inflammatory, and genetic dementias represent a not negligible number of disorders, with increasing numbers in younger subjects. Due to the heterogeneity of patients and disorders, the diagnosis of dementia is challenging. In the present article, we propose a practical diagnostic approach following the two-step investigation procedure. The first step includes basic blood tests and brain neuroimaging, performed on all patients...
December 2, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29197989/direct-genetic-characterization-of-toxoplasma-gondii-from-clinical-samples-from-denmark-not-only-genotypes-ii-and-iii
#14
P Jokelainen, J-B Murat, H V Nielsen
Genetic variation within Toxoplasma gondii can have both clinical and epidemiological significance, while the genotypes circulating in many parts of the world, including the Nordic country Denmark, are still unknown. We genetically characterized T. gondii strains that had been detected in human clinical samples in Denmark in 2011-2016. Samples that had tested positive for T. gondii DNA and had a quantification cycle value <33 were included in this study and subjected to direct genetic characterization of T...
December 3, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29196112/long-term-outcomes-and-prognostic-factors-in-patients-with-mild-hemoptysis
#15
Joonsung Choi, Jun Hyun Baik, Chi Hong Kim, So Hyang Song, Sung Kyung Kim, Myeongjong Kim, Sungeun Yun
OBJECTIVE: The aim of this retrospective study was to observe the long-term outcomes of conservative treatment and bronchial artery embolization (BAE) in patients with mild hemoptysis and to analyze the risk factors associated with hemoptysis recurrence. METHODS: Patients with mild hemoptysis from January 2005 to January 2016 were enrolled in this study. The patients' medical records, including smoking history, etiologic diseases, bronchoscopic findings, mortality, BAE information, and follow-up data of recurrent hemoptysis, were reviewed and analyzed...
November 27, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29195553/impact-of-a-monolithic-silicon-detector-operating-in-transmission-mode-on-clinical-photon-beams
#16
Kananan Utitsarn, Ziyad A Alrowaili, Nauljan Stansook, Marco Petasecca, Martin Carolan, Vladimir L Perevertaylo, Michael Lerch, Anatoly Rosenfeld
PURPOSE: To investigate the effect on surface dose, as a function of different field sizes and distances from the solid water phantom to transmission detector (Dsd), of using the monolithic silicon detector MP512T in transmission mode. METHODS: The influence of operating the MP512T in transmission mode on the surface dose of a phantom for SSD 100cm was evaluated by using a Markus IC. The MP512T was fixed to an adjustable stand holder and was positioned at different Dsd, ranging from 0...
November 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29191248/squamous-cell-carcinoma-arising-from-a-keratocystic-odontogenic-tumor-a-case-report
#17
Rajapakse Mudiyanselage Sumudu Himesha Bandara Medawela, Nadeena Sri Swarnaguptha Jayasuriya, Dugganna Ralalage Dilini Lalanthi Ratnayake, Ajith Manjula Attygalla, Bogahawatte Samarakoon Mudiyanselage Samadarani Siriwardena
BACKGROUND: The term "primary intraosseous squamous cell carcinoma" was introduced in 2005 by the World Health Organization with three subcategories. Squamous cell carcinoma arising from the lining of an odontogenic cyst is one important rare subcategory of such lesions with an incidence of 0.01 to 0.02%. Furthermore, the appearance of such malignancy in an odontogenic tumor such as keratocystic odontogenic tumor is considered extremely rare. CASE PRESENTATION: In this case report we report a case of a 50-year-old Sri Lankan woman who complained of pain and increase in the size of a swelling at the anterior mandible, which had been present for over 1 year...
December 1, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29189384/the-evolution-of-surgical-strategies-for-pancreatic-neuroendocrine-tumors-pan-nens-time-trend-and-outcome-analysis-from-587-consecutive-resections-at-a-high-volume-institution
#18
Luca Landoni, Giovanni Marchegiani, Tommaso Pollini, Sara Cingarlini, Mirko D'Onofrio, Paola Capelli, Riccardo De Robertis, Maria V Davì, Antonio Amodio, Harmony Impellizzeri, Anna Malpaga, Marco Miotto, Letizia Boninsegna, Lorenzo Crepaz, Chiara Nessi, Caterina C Zingaretti, Salvatore Paiella, Alessandro Esposito, Luca Casetti, Giuseppe Malleo, Massimiliano Tuveri, Giovanni Butturini, Roberto Salvia, Aldo Scarpa, Massimo Falconi, Claudio Bassi
OBJECTIVE: The objective of the present analysis is 2-fold: first, to define the evolution of time trends on the surgical approach to pancreatic neuroendocrine neoplasms (Pan-NENs); second, to perform a complete analysis of the predictors of oncologic outcome. BACKGROUND: Reflecting their rarity and heterogeneity, Pan-NENs represent a clinical dilemma. In particular, there is a scarcity of data regarding their long-term follow-up after surgical resection. METHODS: From the Institutional Pan-NEN database, 587 resected cases from 1990 to 2015 were extracted...
November 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29188319/a-dedicated-paracentesis-clinic-decreases-healthcare-utilization-for-serial-paracenteses-in-decompensated-cirrhosis
#19
Yao-Wen Cheng, Kumar Sandrasegaran, Katherine Cheng, Angela Shah, Marwan Ghabril, William Berry, Craig Lammert, Naga Chalasani, Eric S Orman
PURPOSE: The purpose of the study is to describe the effect of a dedicated paracentesis clinic on healthcare utilization by patients with decompensated cirrhosis and refractory ascites. METHODS: This Institutional Review Board-approved retrospective study identified cirrhotic patients receiving paracenteses over a 6-month period before and after creating the paracentesis clinic. Patients were followed for 12 months to collect outcome data including characteristics of subsequent hospitalizations and paracenteses...
November 29, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29185542/pimavanserin-a-novel-therapeutic-option-for-parkinson-disease-psychosis
#20
REVIEW
Trevor Hawkins, Brian D Berman
Purpose of review: In April 2016, the Food and Drug Administration (FDA) approved a first-in-class atypical antipsychotic medication called pimavanserin for the treatment of Parkinson disease psychosis (PDP). We aim to inform readers about its indications, effectiveness, and safety profile. Recent findings: Pimavanserin acts as an inverse agonist at serotonin 5-HT2A receptors and has negligible effects on other receptors, thereby avoiding the D2 receptor antagonism that can potentially worsen motor symptoms...
April 2017: Neurology. Clinical Practice
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