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https://www.readbyqxmd.com/read/29792850/microrna-182-inhibits-hcmv-replication-through-activation-of-type-i-ifn-response-by-targeting-foxo3
#1
Xia He, Junfang Teng, Can Cui, Dongrui Li, Lijun Wen
Human cytomegalovirus (HCMV) has led to kinds of clinical disorders and great morbidity worldwide, such as sensorineural hearing loss (SNHL), mental retardation, and developmental delays in immunocompromised individuals. Previous studies reported that HCMV has evolved a variety of mechanisms to evade the immune system, such as dysregulation of miRNAs. However, reports concerning the role of miRNA in HCMV infection are limited. Here, we reported that a host microRNA, miR-182, was significantly up-regulated by HCMV infection in U-251MG and NPCs cells...
May 21, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29791932/b3galnt2-related-dystroglycanopathy-expansion-of-the-phenotype-with-novel-mutation-associated-with-muscle-eye-brain-disease-walker-warburg-syndrome-epileptic-encephalopathy-west-syndrome-and-sensorineural-hearing-loss
#2
Muna A Al Dhaibani, Ayman W El-Hattab, Omar Ismayl, Jehan Suleiman
Mutations in B3GALNT2 , encoding a glycosyltransferase enzyme involved in α-dystroglycan glycosylation, have been recently associated with dystroglycanopathy, a well-recognized subtype of congenital muscular dystrophy (CMD). Only a few cases have been reported with B3GALNT2 -related dystroglycanopathy with variable severity ranging from mild CMD to severe muscle-eye-brain disease. Here, we describe a child with a novel homozygous nonsense mutation in B3GALNT2 . The affected child has severe neurological disease since birth, including muscle disease manifested as hypotonia, muscle weakness, and wasting with elevated creatine kinase, eye disease including microphthalmia and blindness, brain disease with extensive brain malformations including massive hydrocephalus, diffuse cobblestone-lissencephaly, deformed craniocervical junction, and pontocerebellar hypoplasia...
May 23, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29791909/iodine-induced-fetal-hypothyroidism-diagnosis-and-treatment-with-intra-amniotic-levothyroxine
#3
Macy T Hardley, Andrew H Chon, Jorge Mestman, Caroline T Nguyen, Mitchell E Geffner, Ramen H Chmait
BACKGROUND: Iodine is necessary for fetal thyroid development. Excess maternal intake of iodine can cause fetal hypothyroidism due to the inability to escape from the Wolff-Chaikoff effect in utero. CASE REPORT: We report a case of fetal hypothyroid goiter secondary to inadvertent excess maternal iodine ingestion from infertility supplements. The fetus was successfully treated with intra-amniotic levothyroxine injections. Serial fetal blood sampling confirmed fetal escape from the Wolff-Chaikoff effect in the mid third trimester...
May 23, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29791644/temporal-analysis-of-the-functional-status-of-older-people-in-the-state-of-para%C3%A3-ba-brazil
#4
Fabiana Ferraz Queiroga Freitas, Cinara Maria Feitosa Beleza, Isadora Queiroz Correa Garchet Furtado, Aline da Rocha Kallás Fernandes, Sônia Maria Soares
OBJECTIVE: To verify the profile and the functional status of older people living in the state of Paraíba, Brazil, from a temporal perspective. METHOD: This was a descriptive study with secondary analysis of data from the Health Indicator and Aging Policy Monitoring system (SISAP-Idoso - Sistema de Indicadores de Saúde e Acompanhamento de Políticas do Idoso) between 2000 and 2010. RESULTS: Over the analyzed period, there was a growth of older women, people older than 85 years, residents of urban areas, older people who live alone and who are not responsible for the household...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791621/speech-language-pathology-aspects-in-a-pediatric-case-of-head-and-neck-arthrogryposis
#5
Jennifer Alvares Trindade, Jordana da Silva Freitas, Liliane Menzen, Carolina Laux, Lisiane de Rosa Barbosa, Maria Cristina de Almeida Freitas Cardoso
Arthrogryposis is a rare, multiple, congenital syndrome of non-progressive nature characterized by a series of genetic malformations, as well as stiffness and joint contractures. This is a clinical case study whose objective is to describe speech-language pathology disorders through the evaluation process in a case of arthrogryposis in Pediatrics. The medical records of a patient were analyzed from birth. A complete clinical evaluation of pediatric dysphagia was performed, establishing a diagnosis of severe oropharyngeal dysphagia evidenced by functional and structural impairments...
2018: CoDAS
https://www.readbyqxmd.com/read/29791559/sequential-analysis-as-a-tool-for-detection-of-amikacin-ototoxicity-in-the-treatment-of-multidrug-resistant-tuberculosis
#6
Karla Anacleto de Vasconcelos, Silvana Maria Monte Coelho Frota, Antonio Ruffino-Netto, Afrânio Lineu Kritski
OBJECTIVE: To investigate early detection of amikacin-induced ototoxicity in a population treated for multidrug-resistant tuberculosis (MDR-TB), by means of three different tests: pure-tone audiometry (PTA); high-frequency audiometry (HFA); and distortion-product otoacoustic emission (DPOAE) testing. METHODS: This was a longitudinal prospective cohort study involving patients aged 18-69 years with a diagnosis of MDR-TB who had to receive amikacin for six months as part of their antituberculosis drug regimen for the first time...
April 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29790978/mobilization-of-the-anterior-posterior-inferior-cerebellar-artery-on-the-cerebellar-surface-in-microvascular-decompression-surgery-for-hemifacial-spasm-potential-effect-on-hearing-preservation
#7
Kenichi Amagasaki, Saiko Watanabe, Atushi Hosono, Hiroshi Nakaguchi
BACKGROUND: The infrafloccular approach in microvascular decompression (MVD) for hemifacial spasm (HFS) reduces the risk of postoperative hearing impairment. However, location of the anterior/posterior inferior cerebellar artery (AICA/PICA) on the cerebellar surface in the surgical route requires mobilization to maintain the approach direction for the protection of hearing function. OBJECTIVE: To evaluate the effectiveness of mobilization of the AICA/PICA on the cerebellar surface in the surgical route...
May 22, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29790807/study-of-mitochondrial-dna-a1555g-and-c1494t-mutations-in-a-large-cohort-of-women-individuals
#8
Lin Wang, Xiaobin Wang, Xiaolong Cai, Rong Qiang
Mammalian mitochondrial A1555G and C1494T mutations are the most common causes of aminoglycoside-induced and non-syndromic hearing loss. However, these two mutations always are studied in the subject of pedigrees analysis. In the present study, we aimed to investigate the genetic characteristic of the A1555G and C1494T mutations on the population-level sampling, and to study the A1555G pattern of maternal transmission in three heteroplasmic families. Four thousand two hundred and ten unrelated women with normal hearing were enrolled as subjects...
May 23, 2018: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/29790660/drama-to-promote-non-verbal-communication-skills
#9
Martina Kelly, Lara Nixon, Kirsten Broadfoot, Marianna Hofmeister, Tim Dornan
BACKGROUND: Non-verbal communication skills (NVCS) help physicians to deliver relationship-centred care, and the effective use of NVCS is associated with improved patient satisfaction, better use of health services and high-quality clinical care. In contrast to verbal communication skills, NVCS training is under developed in communication curricula for the health care professions. One of the challenges teaching NVCS is their tacit nature. In this study, we evaluated drama exercises to raise awareness of NVCS by making familiar activities 'strange'...
May 23, 2018: Clinical Teacher
https://www.readbyqxmd.com/read/29790248/diagnosis-and-management-of-conductive-hearing-loss-in-children-with-trisomy-21
#10
Robbie Stewart, Donna Gallagher, Peter Leyden
AIM: The objective of this study is to review the prevalence and degree of hearing loss in children with trisomy 21, their response to intervention and the presence of concomitant pathologies. The project will also highlight the experiences of the children from their parents' and guardians' perspective and the link between perceived service quality and an objective improvement in their hearing after rehabilitation. METHODS: All patients with trisomy 21 who were referred to district general otolaryngology outpatient clinics between 2014 and 2016 were included...
May 22, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29790122/talking-points-a-modulating-circle-reduces-listening-effort-without-improving-speech-recognition
#11
Julia F Strand, Violet A Brown, Dennis L Barbour
Speech recognition is improved when the acoustic input is accompanied by visual cues provided by a talking face (Erber in Journal of Speech and Hearing Research, 12(2), 423-425 1969; Sumby & Pollack in The Journal of the Acoustical Society of America, 26(2), 212-215, 1954). One way that the visual signal facilitates speech recognition is by providing the listener with information about fine phonetic detail that complements information from the auditory signal. However, given that degraded face stimuli can still improve speech recognition accuracy (Munhall et al...
May 22, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29789864/-vascularized-tumor-of-the-retroauricular-skin
#12
P Meister, W Kelker, U Gößler, R Hammerstingl, T J Vogl, R Winkelmann
An 84-year-old female patient with loss of hearing and otorrhoea went to an otolaryngologist. On examination, a polypoid mass in the auditory canal and a retroauricular skin lesion, possibly seborrheic keratosis, were found. Only the skin was submitted for histological examination and showed a cutaneous highly vascular lesion with an associated "zellballen" of clear cells without atypia. The initial diagnosis was that of a cutaneous glomangioma. Immunohistochemical findings favored diagnosis of a paraganglioma...
May 22, 2018: Der Pathologe
https://www.readbyqxmd.com/read/29789749/the-global-south-is-rich-in-sustainability-lessons-that-students-deserve-to-hear
#13
Harini Nagendra
No abstract text is available yet for this article.
May 2018: Nature
https://www.readbyqxmd.com/read/29789373/voltage-gated-calcium-influx-modifies-cholinergic-inhibition-of-inner-hair-cells-in-the-immature-rat-cochlea
#14
Stephen Zachary, Nathaniel Nowak, Pankhuri Vyas, Luke Bonanni, Paul Albert Fuchs
Until postnatal day 12, inner hair cells of the rat cochlea are invested with both afferent and efferent synaptic connections. With the onset of hearing at P12, the efferent synapses disappear, and afferent (ribbon) synapses operate with greater efficiency. This change coincides with increased expression of voltage-gated potassium channels, the loss of calcium-dependent electrogenesis, and the onset of graded receptor potentials driven by sound. The transient efferent synapses include near-membrane postsynaptic cisterns thought to regulate calcium influx through the hair cell's α9α10-nAChR that activates small conductance Ca2+ -activated K+ (SK) channels...
May 22, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29789088/the-danger-zone-for-noise-hazards-around-the-black-hawk-helicopter
#15
Heath G Jones, Nathaniel T Greene, Michael R Chen, Cierrah M Azcona, Brandon J Archer, Efrem R Reeves
BACKGROUND: During ground operations, rotary-wing aircraft engines and subsystems produce noise hazards that place airfield personnel at risk for hearing damage. The noise exposure levels outside the aircraft during various operating conditions, and the distances from aircraft at which they drop to safe levels, are not readily available. The current study measured noise levels at various positions around the UH-60 Black Hawk helicopter for three operating conditions typically used when the aircraft is on the ground...
June 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29788439/repair-of-temporal-bone-defects-via-the-middle-cranial-fossa-approach-treatment-of-2-pathologies-with-1-operation
#16
Daniel B Eddelman, Stephan Munich, Ryan B Kochanski, Michael Eggerstedt, Robert P Kazan, Roham Moftakhar, Lorenzo Munoz, Rich W Byrne, R Mark Wiet
BACKGROUND: Temporal bone dehiscence (TBD) often results in leakage of cerebrospinal fluid (CSF) and/or encephalocele. TBD can also occur over the superior semicircular canal, causing debilitating vertigo. Both can be repaired surgically, but traditional treatment is focused only on one pathology, not both. OBJECTIVE: To report our experience in the treatment of TBD via the middle cranial fossa (MCF) approach. METHODS: A retrospective review was conducted for all patients who underwent MCF approach for surgical repair of any temporal fossa dehiscence...
May 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29788437/retromastoid-approach-for-posterior-fossa-skull-base-rosai-dorfman-disease-a-rare-pathology-3-dimensional-operative-video
#17
Anil Nanda, Amey R Savardekar, Devi Prasad Patra, Rimal Hanif Dossani, Maria-Magdalena Georgescu
Rosai-Dorfman disease, originally described by Juan Rosai and Ronald F. Dorfman, is a rare benign histiocytic proliferative disorder, classically presenting with massive lymphadenopathy and a self-limiting clinical course.1 Isolated intracranial skull base involvement is extremely rare and often resembles meningiomas, schwannomas, or other benign skull base lesions.2 The disease is difficult to diagnose radiographically, and tissue diagnosis with open skull base approaches has significant perioperative risks...
May 21, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29788270/determinants-of-hearing-aid-use-among-older-americans-with-hearing-loss
#18
Michael M McKee, HwaJung Choi, Shelby Wilson, Melissa J DeJonckheere, Philip Zazove, Helen Levy
Background and Objectives: Hearing loss (HL) is common among older adults and is associated with significant psychosocial, cognitive, and physical sequelae. Hearing aids (HA) can help, but not all individuals with HL use them. This study examines how social determinants may impact HA use. Research Design and Methods: We conducted an explanatory sequential mixed methods study involving a secondary analysis of a nationally representative data set, the Health and Retirement Study (HRS; n = 35,572)...
May 21, 2018: Gerontologist
https://www.readbyqxmd.com/read/29787726/hearing-representing-the-aural-wallpaper
#19
David McAlpine
Human listeners appear to represent the textures of sounds through a process of automatic time averaging that exists beyond volition. This process distils likely background sounds into their summary statistics, a computationally efficient way of dealing with complex auditory scenes.
May 21, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29787354/optical-coherence-tomography-of-the-tympanic-membrane-and-middle-ear-a-review
#20
Hsern Ern Ivan Tan, Peter Luke Santa Maria, Philip Wijesinghe, Brendan Francis Kennedy, Benjamin James Allardyce, Robert Henry Eikelboom, Marcus David Atlas, Rodney James Dilley
Objective To evaluate the recent developments in optical coherence tomography (OCT) for tympanic membrane (TM) and middle ear (ME) imaging and to identify what further development is required for the technology to be integrated into common clinical use. Data Sources PubMed, Embase, Google Scholar, Scopus, and Web of Science. Review Methods A comprehensive literature search was performed for English language articles published from January 1966 to January 2018 with the keywords "tympanic membrane or middle ear,"optical coherence tomography," and "imaging...
May 1, 2018: Otolaryngology—Head and Neck Surgery
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