Beatriz Castillo Rodriguez, Eric A Secemsky, Rajesh V Swaminathan, Dmitriy N Feldman, Markus Schlaich, Yuri Battaglia, Edward Filippone, Chayakrit Krittanawong
Hypertension is a primary contributor to cardiovascular disease, and the leading risk factor for loss of quality adjusted life years. Up to 50% of the cases of hypertension in the US remain uncontrolled. Additionally, 8-18% of the hypertensive population have resistant hypertension, uncontrolled pressure despite three different anti-hypertensive agents. Recently, catheter-based, percutaneous renal denervation emerged as a method for ablating renal sympathetic nerves for difficult to control hypertension. Initial randomized (non-sham) trials and registry analyses showed impressive benefit, but the first sham-controlled randomized controlled trial (RCT) using monopolar radiofrequency ablation showed limited benefit...
April 6, 2024: American Journal of Medicine