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https://www.readbyqxmd.com/read/29792920/inner-ear-drug-delivery-recent-advances-challenges-and-perspective
#1
Jinsong Hao, S Kevin Li
Effective and safe treatment of auditory and vestibular diseases has become increasingly dependent on inner ear drug delivery systems. This review highlights recent advances in inner ear drug delivery research and technologies. The focus is on strategies to overcome delivery barriers and to improve drug residence and targeting, with special attention to in vivo animal and human studies. The research in gene and stem cell delivery to the inner ear is briefly reviewed. Newly developed research tools to address experimental challenges and safety issues are discussed...
May 21, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29792913/comparison-of-cerebral-ventricular-volumes-and-cortical-thicknesses-in-normal-rats-and-genetic-absence-epilepsy-gaers-a-developmental-study
#2
Özlem Kirazlı, Hüsniye Hacıoğlu Bay, Yusuf Özgür Çakmak, Filiz Onat, Safiye Çavdar
Ventricular enlargement and cortical atrophy have been associated with various central nervous system diseases. The aim of the present study was to measure the volumes of the lateral (LV) and third (3V) ventricles and to determine the cortical thickness for the motor (MCx), somatosensory (SSCx), visual (VCx) and auditory (AuCx) cortex and the striatum of Wistar rats, in a developmental series at 10, 20, 30, and 60 days postnatal, and to compare them with similar data from genetic absence epilepsy rats from Strasbourg (GAERS)...
May 21, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29792887/auditory-priming-improves-neural-synchronization-in-auditory-motor-entrainment
#3
Jewel E Crasta, Michael H Thaut, Charles W Anderson, Patricia L Davies, William J Gavin
Neurophysiological research has shown that auditory and motor systems interact during movement to rhythmic auditory stimuli through a process called entrainment. This study explores the neural oscillations underlying auditory-motor entrainment using electroencephalography. Forty young adults were randomly assigned to one of two control conditions, an auditory-only condition or a motor-only condition, prior to a rhythmic auditory-motor synchronization condition (referred to as combined condition). Participants assigned to the auditory-only condition (auditory-first group) listened to 400 trials of auditory stimuli presented every 800ms, while those in the motor-only condition (motor-first group) were asked to tap rhythmically every 800ms without any external stimuli...
May 21, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29792885/effects-of-vasopressin-on-neural-processing-of-infant-crying-in-expectant-fathers
#4
Sandra Thijssen, Anna E Van 't Veer, Jurriaan Witteman, Willemijn M Meijer, Marinus H van IJzendoorn, Marian J Bakermans-Kranenburg
In a randomized, double blind, placebo-controlled, within-subject magnetic resonance imaging study, we examined the effect of 20 IU intranasal vasopressin on the neural processing of infant crying in 25 fathers-to-be. We explored whether familial background modulates vasopressin effects, and whether vasopressin differentially affects cry processing coupled with neutral or emotional contextual information. Participants listened to cries accompanied by neutral ('this is an infant') or emotional ('this infant is sick/bored') contextual information, and neutral control sounds ('this is a saw')...
May 21, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29792444/automaticity-in-the-recognition-of-nonverbal-emotional-vocalizations
#5
César F Lima, Andrey Anikin, Ana Catarina Monteiro, Sophie K Scott, São Luís Castro
The ability to perceive the emotions of others is crucial for everyday social interactions. Important aspects of visual socioemotional processing, such as the recognition of facial expressions, are known to depend on largely automatic mechanisms. However, whether and how properties of automaticity extend to the auditory domain remains poorly understood. Here we ask if nonverbal auditory emotion recognition is a controlled deliberate or an automatic efficient process, using vocalizations such as laughter, crying, and screams...
May 24, 2018: Emotion
https://www.readbyqxmd.com/read/29791619/temporal-ordering-and-reading-competence-of-words-and-pseudowords-a-preliminary-study
#6
Cintia Alves de Souza, Andrezza Gonzalez Escarce, Stela Maris Aguiar Lemos
Purpose Analyze the association of simple and complex auditory temporal ordering skills with reading competence tasks in students. Methods Pilot phase of a cross-sectional study conducted with a non-probabilistic sample of 22 schoolchildren aged eight to ten years. Instruments for evaluation of reading competence tasks and simple and complex auditory temporal ordering abilities were used. Results Most participants obtained adequate results in the tests of simple auditory temporal ordering (SATO) and reading competence (RC), but inadequate results in the test of complex auditory temporal ordering (CATO)...
2018: CoDAS
https://www.readbyqxmd.com/read/29791617/speech-perception-task-with-pseudowords
#7
Mariana Martins Appezzato, Maria Mercedes Saraiva Hackerott, Clara Regina Brandão de Avila
Purpose Prepare a list of pseudowords in Brazilian Portuguese to assess the auditory discrimination ability of schoolchildren and investigate the internal consistency of test items and the effect of school grade on discrimination performance. Methods Study participants were 60 schoolchildren (60% female) enrolled in the 3rd (n=14), 4th (n=24) and 5th (n=22) grades of an elementary school in the city of Sao Paulo, Brazil, aged between eight years and two months and 11 years and eight months (99 to 136 months; mean=120...
2018: CoDAS
https://www.readbyqxmd.com/read/29791616/short-and-long-latency-auditory-evoked-potentials-in-individuals-with-vestibular-dysfunction
#8
Valdete Alves Valentins Dos Santos Filha, Mirtes Bruckmann, Michele Vargas Garcia
Purpose Evaluate the auditory pathway at the brainstem and cortical levels in individuals with peripheral vestibular dysfunction. Methods The study sample was composed 19 individuals aged 20-80 years that presented exam results suggestive of Peripheral Vestibular Disorder (PVD) or Vestibular Dysfunction (VD). Participants underwent evaluation of the auditory pathway through Brainstem Auditory Evoked Potentials (BAEP) (short latency) and P1, N1, P2, N2, and P300 cortical potentials (long latency). Results Nine individuals presented diagnosis of VD and 10 participants were diagnosed with PVD...
2018: CoDAS
https://www.readbyqxmd.com/read/29791271/language-skills-but-not-frequency-discrimination-predict-reading-skills-in-children-at-risk-of-dyslexia
#9
Margaret J Snowling, Debbie Gooch, Genevieve McArthur, Charles Hulme
This study evaluated the claim that auditory processing deficits are a cause of reading and language difficulties. We report a longitudinal study of 245 children at family risk of dyslexia, children with preschool language impairments, and control children. Children with language impairments had poorer frequency-discrimination thresholds than controls at 5.5 years, but children at family risk of dyslexia did not. A model assessing longitudinal relationships among frequency discrimination, reading, language, and executive function skills showed that frequency discrimination was predicted by executive skills but was not a longitudinal predictor of reading or language skills...
May 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29790978/mobilization-of-the-anterior-posterior-inferior-cerebellar-artery-on-the-cerebellar-surface-in-microvascular-decompression-surgery-for-hemifacial-spasm-potential-effect-on-hearing-preservation
#10
Kenichi Amagasaki, Saiko Watanabe, Atushi Hosono, Hiroshi Nakaguchi
BACKGROUND: The infrafloccular approach in microvascular decompression (MVD) for hemifacial spasm (HFS) reduces the risk of postoperative hearing impairment. However, location of the anterior/posterior inferior cerebellar artery (AICA/PICA) on the cerebellar surface in the surgical route requires mobilization to maintain the approach direction for the protection of hearing function. OBJECTIVE: To evaluate the effectiveness of mobilization of the AICA/PICA on the cerebellar surface in the surgical route...
May 22, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29790835/tuning-for-the-rate-and-duration-of-frequency-modulated-fm-sweeps-in-the-mammalian-inferior-colliculus
#11
James Alexander Morrison, Roberto Valdizón-Rodríguez, Daniel Goldreich, Paul A Faure
Responses of auditory duration-tuned neurons (DTNs) are selective for stimulus duration. We used single-unit extracellular recording to investigate how the inferior colliculus (IC) encodes frequency modulated (FM) sweeps in the big brown bat. It was unclear whether the responses of so-called "FM DTNs" encode signal duration, like classic pure tone DTNs, or the FM sweep rate. Most FM cells had spiking responses selective for downward FM sweeps. We presented cells with linear FM sweeps whose center frequency (CEF) was set to the best excitatory frequency and whose bandwidth (BW) maximized the spike count...
May 23, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29790722/minimally-invasive-endoscopic-assisted-approaches-to-the-posterior-fossa
#12
Alexander Yang, Zach Folzenlogen, A Samy Youssef
Modern surgical approaches are becoming more minimalistic, associated with the term 'minimally invasive'. The endoscope provides a more panoramic anatomical view in addition to the ability to access narrow deep corners with decent illumination and clear visualization. Endoscopic assisted microsurgery through a tailored small craniotomy is the foundation of keyhole surgery. The endoscope can be advanced deeper into the field, thus enhancing an exposure and allowing bimanual dissection, thus prompting smaller craniotomies and tailored key exposures...
May 22, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29790684/the-effect-of-music-on-the-cardiac-activity-of-a-fetus-in-a-cardiotocographic-examination
#13
Grażyna Gebuza, Marta Zaleska, Marzena Kaźmierczak, Estera Mieczkowska, Małgorzata Gierszewska
BACKGROUND: Music therapy as an adjunct to treatment is rarely used in perinatology and obstetrics, despite the proven therapeutic effect. Auditory stimulation through music positively impacts the health of adults and infants, its special role being observed in the development of prematurely born neonates. It is equally interesting how music impacts fetuses. OBJECTIVES: The aim of this study is to assess the parameters of fetuses through cardiotocographic recording in women in the 3rd trimester of pregnancy while listening to Pyotr Tchaikovsky's "Sleeping Beauty" and "Swan Lake...
April 24, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790568/-social-cognition-and-cognitive-functions-in-patients-with-epilepsy-treated-with-eslicarbazepine-acetate
#14
L Abraira, A Sanabria, G Ortega, M Quintana, E Santamarina, J Salas-Puig, M Toledo
INTRODUCTION: Epilepsy is accompanied by cognitive disorders, frequently aggravated by the use of antiepileptic drugs, which can affect social empathy. AIM: To analyse the impact of treatment with eslicarbazepine acetate (ESL) on social cognition and prefrontal cognitive functions in adults with focal epilepsy. PATIENTS AND METHODS: We conducted a prospective single-centre study with patients aged between 18 and 65 years with focal seizures treated with ESL...
June 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29790268/ask-me-children-s-experiences-of-pain-explored-using-the-draw-write-and-tell-method
#15
Nicole Pope, Mary Tallon, Gavin Leslie, Sally Wilson
PURPOSE: Pain management within emergency departments (ED) remains challenging. Given that unrelieved pain in children is linked to a number of negative physiological and psychological consequences, optimal management of children's pain is paramount. Many studies exploring children's pain have adopted quantitative methods or sought the perspectives of adults. Compared to adults, studies examining children's views on pain and pain management are limited. This study aimed to explore children's pain experiences, their perception of pain management and expectations of the role of the nurse...
May 23, 2018: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/29790122/talking-points-a-modulating-circle-reduces-listening-effort-without-improving-speech-recognition
#16
Julia F Strand, Violet A Brown, Dennis L Barbour
Speech recognition is improved when the acoustic input is accompanied by visual cues provided by a talking face (Erber in Journal of Speech and Hearing Research, 12(2), 423-425 1969; Sumby & Pollack in The Journal of the Acoustical Society of America, 26(2), 212-215, 1954). One way that the visual signal facilitates speech recognition is by providing the listener with information about fine phonetic detail that complements information from the auditory signal. However, given that degraded face stimuli can still improve speech recognition accuracy (Munhall et al...
May 22, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29790074/attentional-modulation-of-desensitization-to-odor
#17
Nicholas Fallon, Timo Giesbrecht, Andrej Stancak
Subjective and behavioral responsiveness to odor diminishes during prolonged exposure. The precise mechanisms underlying olfactory desensitization are not fully understood, but previous studies indicate that the phenomenon may be modulated by central-cognitive processes. The present study investigated the effect of attention on perceived intensity during exposure to a pleasant odor. A within-subjects design was utilized with 19 participants attending 2 sessions. During each session, participants continuously rated their perceived intensity of a 10-minute exposure to a pleasant fragrance administered using an olfactometer...
May 22, 2018: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29789937/visual-and-auditory-steady-state-responses-in-attention-deficit-hyperactivity-disorder
#18
Ali Khaleghi, Hadi Zarafshan, Mohammad Reza Mohammadi
We designed a study to investigate the patterns of the steady-state visual evoked potential (SSVEP) and auditory steady-state response (ASSR) in adolescents with attention-deficit/hyperactivity disorder (ADHD) when performing a motor response inhibition task. Thirty 12- to 18-year-old adolescents with ADHD and 30 healthy control adolescents underwent an electroencephalogram (EEG) examination during steady-state stimuli when performing a stop-signal task. Then, we calculated the amplitude and phase of the steady-state responses in both visual and auditory modalities...
May 22, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29789864/-vascularized-tumor-of-the-retroauricular-skin
#19
P Meister, W Kelker, U Gößler, R Hammerstingl, T J Vogl, R Winkelmann
An 84-year-old female patient with loss of hearing and otorrhoea went to an otolaryngologist. On examination, a polypoid mass in the auditory canal and a retroauricular skin lesion, possibly seborrheic keratosis, were found. Only the skin was submitted for histological examination and showed a cutaneous highly vascular lesion with an associated "zellballen" of clear cells without atypia. The initial diagnosis was that of a cutaneous glomangioma. Immunohistochemical findings favored diagnosis of a paraganglioma...
May 22, 2018: Der Pathologe
https://www.readbyqxmd.com/read/29789504/the-sound-of-words-evokes-affective-brain-responses
#20
Arash Aryani, Chun-Ting Hsu, Arthur M Jacobs
The long history of poetry and the arts, as well as recent empirical results suggest that the way a word sounds (e.g., soft vs. harsh) can convey affective information related to emotional responses (e.g., pleasantness vs. harshness). However, the neural correlates of the affective potential of the sound of words remain unknown. In an fMRI study involving passive listening, we focused on the affective dimension of arousal and presented words organized in two discrete groups of sublexical (i.e., sound) arousal (high vs...
May 23, 2018: Brain Sciences
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