keyword
MENU ▼
Read by QxMD icon Read
search

Synthetic heart valve

keyword
https://www.readbyqxmd.com/read/27780764/biodegradable-and-biomimetic-elastomeric-scaffolds-for-tissue-engineered-heart-valves
#1
REVIEW
Yingfei Xue, Vinayak Sant, Julie Phillippi, Shilpa Sant
Valvular heart diseases are the third leading cause of cardiovascular disease, resulting in more than 25,000 deaths annually in the United States. Heart valve tissue engineering (HVTE) has emerged as a putative treatment strategy such that the designed construct would ideally withstand native dynamic mechanical environment, guide regeneration of the diseased tissue and more importantly, have the ability to grow with the patient. These desired functions could be achieved by biomimetic design of tissue-engineered constructs that recapitulate in vivo heart valve microenvironment with biomimetic architecture, optimal mechanical properties and possess suitable biodegradability and biocompatibility...
October 22, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27150672/heart-valves-from-polyester-fibers-vs-biological-tissue-comparative-study-in-vitro
#2
Atieh Yousefi, Antoine Vaesken, Amna Amri, Lakshmi Prasad Dasi, Frederic Heim
Transcatheter aortic valve implantation (TAVI) has become a popular alternative technique to surgical valve replacement for critical patients. Biological valve tissue has been used in TAVI procedures for over a decade, with over 100,000 implantations to date. However, with only 6 years follow up, little is known about the long-term durability of biological tissue. Moreover, the high cost of tissue harvesting and chemical treatment procedures favor the development of alternative synthetic valve leaflet materials...
May 5, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27028286/euromedicat-signal-detection-an-evaluation-of-selected-congenital-anomaly-medication-associations
#3
Joanne E Given, Maria Loane, Johannes M Luteijn, Joan K Morris, Lolkje T W de Jong van den Berg, Ester Garne, Marie-Claude Addor, Ingeborg Barisic, Hermien de Walle, Miriam Gatt, Kari Klungsoyr, Babak Khoshnood, Anna Latos-Bielenska, Vera Nelen, Amanda J Neville, Mary O'Mahony, Anna Pierini, David Tucker, Awi Wiesel, Helen Dolk
AIMS: To evaluate congenital anomaly (CA)-medication exposure associations produced by the new EUROmediCAT signal detection system and determine which require further investigation. METHODS: Data from 15 EUROCAT registries (1995-2011) with medication exposures at the chemical substance (5th level of Anatomic Therapeutic Chemical classification) and chemical subgroup (4th level) were analysed using a 50% false detection rate. After excluding antiepileptics, antidiabetics, antiasthmatics and SSRIs/psycholeptics already under investigation, 27 associations were evaluated...
October 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27018545/customized-interface-biofunctionalization-of-decellularized-extracellular-matrix-toward-enhanced-endothelialization
#4
Hug Aubin, Carlos Mas-Moruno, Makoto Iijima, Nicolas Schütterle, Meike Steinbrink, Alexander Assmann, Francesc Javier Gil, Artur Lichtenberg, Marta Pegueroles, Payam Akhyari
Interface biofunctionalization strategies try to enhance and control the interaction between implants and host organism. Decellularized extracellular matrix (dECM) is widely used as a platform for bioengineering of medical implants, having shown its suitability in a variety of preclinical as well as clinical models. In this study, specifically designed, custom-made synthetic peptides were used to functionalize dECM with different cell adhesive sequences (RGD, REDV, and YIGSR). Effects on in vitro endothelial cell adhesion and in vivo endothelialization were evaluated in standardized models using decellularized ovine pulmonary heart valve cusps (dPVCs) and decellularized aortic grafts (dAoGs), respectively...
May 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/26763768/novel-heart-valve-prosthesis-with-self-endothelialization-potential-made-of-modified-polyhedral-oligomeric-silsesquioxane-nanocomposite-material
#5
Hossein Ghanbari, Dina Radenkovic, Sayed Mahdi Marashi, Shirin Parsno, Nima Roohpour, Gaetano Burriesci, Alexander M Seifalian
In the cardiovascular system, the endothelial layer provides a natural antithrombogenic surface on the inner portion of the heart and associated vessels. For a synthetic material therefore, the ability to attract and retain endothelial or endothelial progenitor cells (EPCs), ultimately creating a single endothelial layer on its surface, is of prime importance. The authors have developed a nanocomposite polymer, based on a combination of polyhedral oligomeric silsesquioxane nanoparticles and polycarbonate urea urethane (POSS-PCU), which is biocompatible and has been used in human for the world's first synthetic trachea, tear duct, and bypass graft...
June 2016: Biointerphases
https://www.readbyqxmd.com/read/26656602/fibrous-scaffolds-for-building-hearts-and-heart-parts
#6
REVIEW
A K Capulli, L A MacQueen, Sean P Sheehy, K K Parker
Extracellular matrix (ECM) structure and biochemistry provide cell-instructive cues that promote and regulate tissue growth, function, and repair. From a structural perspective, the ECM is a scaffold that guides the self-assembly of cells into distinct functional tissues. The ECM promotes the interaction between individual cells and between different cell types, and increases the strength and resilience of the tissue in mechanically dynamic environments. From a biochemical perspective, factors regulating cell-ECM adhesion have been described and diverse aspects of cell-ECM interactions in health and disease continue to be clarified...
January 15, 2016: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/26513599/evaluation-of-the-melody-transcatheter-pulmonary-valve-and-ensemble-delivery-system-for-the-treatment-of-dysfunctional-right-ventricle-to-pulmonary-artery-conduits
#7
REVIEW
Jeremy Asnes, William E Hellenbrand
Synthetic conduits and bioprosthetic valves are used in the treatment of patients with congenital heart disease involving the right ventricular outflow tract and pulmonary valve. In-situ time-dependent degradation uniformly results in conduit and valve dysfunction. The abnormal hemodynamics imposed by valve and conduit dysfunction have been linked to exercise intolerance, arrhythmia, right heart failure, and sudden death. Starting in childhood, affected patients are subjected to repeated open-heart surgeries to restore valve function and potentially reduce morbidity and mortality...
2015: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/26466917/superior-tissue-evolution-in-slow-degrading-scaffolds-for-valvular-tissue-engineering
#8
Marieke M C P Brugmans, R Sarita Soekhradj-Soechit, Daphne van Geemen, Martijn Cox, Carlijn V C Bouten, Frank P T Baaijens, Anita Driessen-Mol
Synthetic polymers are widely used to fabricate porous scaffolds for the regeneration of cardiovascular tissues. To ensure mechanical integrity, a balance between the rate of scaffold absorption and tissue formation is of high importance. A higher rate of tissue formation is expected in fast-degrading materials than in slow-degrading materials. This could be a result of synthetic cells, which aim to compensate for the fast loss of mechanical integrity of the scaffold by deposition of collagen fibers. Here, we studied the effect of fast-degrading polyglycolic acid scaffolds coated with poly-4-hydroxybutyrate (PGA-P4HB) and slow-degrading poly-ɛ-caprolactone (PCL) scaffolds on amount of tissue, composition, and mechanical characteristics in time, and compared these engineered values with values for native human heart valves...
January 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/26464819/expression-of-collagen-1-and-elastin-genes-in-mitral-valvular-interstitial-cells-within-microfiber-reinforced-hydrogel
#9
Maryam Eslami, Gholamreza Javadi, Nasser Agdami, Mohammad Ali Shokrgozar
OBJECTIVE: The incidence of heart valve disease is increasing worldwide and the number of heart valve replacements is expected to increase in the future. By mimicking the main tissue structures and properties of heart valve, tissue engineering offers new options for the replacements. Applying an appropriate scaffold in fabricating tissue-engineered heart valves (TEHVs) is of importance since it affects the secretion of the main extracellular matrix (ECM) components, collagen 1 and elastin, which are crucial in providing the proper mechanical properties of TEHVs...
2015: Cell Journal
https://www.readbyqxmd.com/read/26319699/matrix-metalloproteinases-as-regulators-of-vein-structure-and-function-implications-in-chronic-venous-disease
#10
REVIEW
Elisabeth MacColl, Raouf A Khalil
Lower-extremity veins have efficient wall structure and function and competent valves that permit upward movement of deoxygenated blood toward the heart against hydrostatic venous pressure. Matrix metalloproteinases (MMPs) play an important role in maintaining vein wall structure and function. MMPs are zinc-binding endopeptidases secreted as inactive pro-MMPs by fibroblasts, vascular smooth muscle (VSM), and leukocytes. Pro-MMPs are activated by various activators including other MMPs and proteinases. MMPs cause degradation of extracellular matrix (ECM) proteins such as collagen and elastin, and could have additional effects on the endothelium, as well as VSM cell migration, proliferation, Ca(2+) signaling, and contraction...
December 2015: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/26241755/3-dimensional-spatially-organized-peg-based-hydrogels-for-an-aortic-valve-co-culture-model
#11
Daniel S Puperi, Liezl R Balaoing, Ronan W O'Connell, Jennifer L West, K Jane Grande-Allen
Physiologically relevant in vitro models are needed to study disease progression and to develop and screen potential therapeutic interventions for disease. Heart valve disease, in particular, has no early intervention or non-invasive treatment because there is a lack of understanding the cellular mechanisms which lead to disease. Here, we establish a novel, customizable synthetic hydrogel platform that can be used to study cell-cell interactions and the factors which contribute to valve disease. Spatially localized cell adhesive ligands bound in the scaffold promote cell growth and organization of valve interstitial cells and valve endothelial cells in 3D co-culture...
October 2015: Biomaterials
https://www.readbyqxmd.com/read/26101808/assessment-of-parylene-c-thin-films-for-heart-valve-tissue-engineering
#12
Isra Marei, Adrian Chester, Ivan Carubelli, Themistoklis Prodromakis, Tatiana Trantidou, Magdi H Yacoub
BACKGROUND: Scaffolds are a key component of tissue-engineered heart valves (TEHVs). Several approaches had been adopted in the design of scaffolds using both natural and synthetic resources. We have investigated the suitability of parylene C (PC), a vapor deposited polymeric material, for the use as a scaffold in TEHV. AIMS: To evaluate the adsorption of extracellular matrix components onto plasma-activated PC and study the biocompatibility of PC by measuring cellular adhesion, viability, apoptosis, and phenotypic expression of valve endothelial and interstitial cells...
October 2015: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/26080925/scaffolds-a-novel-carrier-and-potential-wound-healer
#13
REVIEW
Chetan Chaudhary, Tarun Garg
A scaffold is comprised of the polymeric central components, which are used to deliver cells, drugs, and genes into the body. Wounds, which lead to a loss of integrity of the skin and skin mortality, are common challenges encountered in plastic and reconstructive surgery. The primary goals of treatment are rapid closure, restoration of function, and aesthetic satisfaction. A paradigm shift is taking place in medicine from using synthetic implants and tissue grafts to a tissue-engineering approach that uses degradable porous material scaffolds integrated with biological cells or molecules to regenerate tissues...
2015: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/26030925/ultrastructural-study-on-the-antibacterial-activity-of-artonin-e-versus-streptomycin-against-staphylococcus-aureus-strains
#14
COMPARATIVE STUDY
Asdren Zajmi, Najihah Mohd Hashim, Mohamed Ibrahim Noordin, Shaden A M Khalifa, Faiqah Ramli, Hapipah Mohd Ali, Hesham R El-Seedi
Staphylococci are facultative anaerobes, perfectly spherical un-encapsulated cocci, with a diameter not exceeding 1 micrometer in diameter. Staphylococcus aureus are generally harmless and remain confined to the skin unless they burrow deep into the body, causing life-threatening infections in bones, joints, bloodstream, heart valves and lungs. Among the 20 medically important staphylococci species, Staphylococcus aureus is one of the emerging human pathogens. Streptomycin had its highest potency against Staphylococcus infections despite the likelihood of getting a resistant type of staphylococcus strains...
2015: PloS One
https://www.readbyqxmd.com/read/26027436/current-progress-in-tissue-engineering-of-heart-valves-multiscale-problems-multiscale-solutions
#15
REVIEW
Daniel Y Cheung, Bin Duan, Jonathan T Butcher
INTRODUCTION: Heart valve disease is an increasingly prevalent and clinically serious condition. There are no clinically effective biological diagnostics or treatment strategies. The only recourse available is replacement with a prosthetic valve, but the inability of these devices to grow or respond biologically to their environments necessitates multiple resizing surgeries and life-long coagulation treatment, especially in children. Tissue engineering has a unique opportunity to impact heart valve disease by providing a living valve conduit, capable of growth and biological integration...
2015: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/25980361/fiber-heart-valve-prosthesis-early-in-vitro-fatigue-results
#16
Antoine Vaesken, Foued Khoffi, Frederic Heim, Florence Dieval, Nabil Chakfe
Transcatheter aortic valve replacement has become today a largely considered alternative technique to surgical valve replacement in patients with high risk for open chest surgery. Biological valve tissue used in the transcatheter devices has shown success over 5 years now, but the procedure remains expensive. Moreover, different studies point out potential degradations that the tissue can undergo when folded to lower diameter and released in calcified environment with irregular geometry, which may jeopardize the durability of the device...
July 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/25962454/-relapsing-polychondritis-a-rare-differential-diagnosis-in-clinical-practice
#17
U Drott, A Huberman
Relapsing polychondritis (RPC) is a chronic immune-mediated inflammatory, systemic disease primarily leading to structural damage and impaired function of cartilage tissue. However, the systemic inflammatory process in RPC can also affect sensory organ structures, the respiratory tract, the nervous and cardiovascular systems as well as the kidneys. The immune-mediated disease leads to recurrent inflammatory attacks causing a progressive degradation of elastic and hyaline cartilage structures, especially in the ears, nose, larynx, trachea and diarthrodial joints...
May 2015: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/25955010/application-of-hydrogels-in-heart-valve-tissue-engineering
#18
Xing Zhang, Bin Xu, Daniel S Puperi, Yan Wu, Jennifer L West, K Jane Grande-Allen
With an increasing number of patients requiring valve replacements, there is heightened interest in advancing heart valve tissue engineering (HVTE) to provide solutions to the many limitations of current surgical treatments. A variety of materials have been developed as scaffolds for HVTE including natural polymers, synthetic polymers, and decellularized valvular matrices. Among them, biocompatible hydrogels are generating growing interest. Natural hydrogels, such as collagen and fibrin, generally show good bioactivity but poor mechanical durability...
2015: Journal of Long-term Effects of Medical Implants
https://www.readbyqxmd.com/read/25899236/importance-of-a-multidisciplinary-approach-and-monitoring-in-fetal-warfarin-syndrome
#19
Daniélle B Silveira, Ernani B da Rosa, Vinicius F de Mattos, Thayse B Goetze, Pricila Sleifer, Fernanda D Santa Maria, Rosana C M Rosa, Rafael F M Rosa, Paulo R G Zen
Warfarin is a synthetic oral anticoagulant that crosses the placenta and can lead to a number of congenital abnormalities known as fetal warfarin syndrome. Our aim is to report on the follow-up from birth to age 8 years of a patient with fetal warfarin syndrome. He presented significant respiratory dysfunction, as well as dental and speech and language complications. The patient was the second child of a mother who took warfarin during pregnancy due to a metallic heart valve. The patient had respiratory dysfunction at birth...
June 2015: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/25842134/engineering-of-a-polymer-layered-bio-hybrid-heart-valve-scaffold
#20
S Jahnavi, T V Kumary, G S Bhuvaneshwar, T S Natarajan, R S Verma
Current treatment strategy for end stage valve disease involves either valvular repair or replacement with homograft/mechanical/bioprosthetic valves. In cases of recurrent stenosis/ regurgitation, valve replacement is preferred choice of treatment over valvular repair. Currently available mechanical valves primarily provide durability whereas bioprosthetic valves have superior tissue compatibility but both lack remodelling and regenerative properties making their utility limited in paediatric patients. With advances in tissue engineering, attempts have been made to fabricate valves with regenerative potential using various polymers, decellularized tissues and hybrid scaffolds...
June 2015: Materials Science & Engineering. C, Materials for Biological Applications
keyword
keyword
14518
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"