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https://www.readbyqxmd.com/read/28087438/dopa-responsive-dystonia-in-chinese-patients-including-a-novel-heterozygous-mutation-in-the-gch1-gene-with-an-intermediate-phenotype-and-one-case-of-prenatal-diagnosis
#1
Wen Zhang, Zhizi Zhou, Xiuzhen Li, Yonglan Huang, Taolin Li, Yunting Lin, Yongxian Shao, Hao Hu, Hongsheng Liu, Li Liu
Dopa-responsive dystonia (DRD) is a rare inherited disorder characterized by childhood-onset dystonia with diurnal fluctuation and dramatic response to levodopa. DRD is caused by the mutations in the genes encoding the enzymes involved in the dopamine and tetrahydrobiopterin (BH4) biosynthesis, including the GTP cyclohydrolase 1 (GCH1) gene and the tyrosine hydroxylase (TH) gene. In order to improve the diagnosis and expand the knowledge of the disease, we collected and analyzed relevant data of clinical diagnosis and molecular mutational analysis in five Chinese patients with DRD...
January 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28071873/cognitive-stress-reduces-the-effect-of-levodopa-on-parkinson-s-resting-tremor
#2
Heidemarie Zach, Michiel F Dirkx, Jaco W Pasman, Bastiaan R Bloem, Rick C Helmich
AIMS: Resting tremor in Parkinson's disease (PD) increases markedly during cognitive stress. Dopamine depletion in the basal ganglia is involved in the pathophysiology of resting tremor, but it is unclear whether this contribution is altered under cognitive stress. We test the hypothesis that cognitive stress modulates the levodopa effect on resting tremor. METHODS: Tremulous PD patients (n = 69) were measured in two treatment conditions (OFF vs. ON levodopa) and in two behavioral contexts (rest vs...
January 10, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28063683/diphasic-dyskinesias-during-levodopa-carbidopa-intestinal-gel-lcig-infusion-in-parkinson-s-disease
#3
Meloni Mario, Solla Paolo, Mascia Mario Marcello, Marrosu Francesco, Cannas Antonino
OBJECTIVES: Levodopa-carbidopa intestinal gel infusion (LCIG) is indicated in patients with advanced levodopa-responsive Parkinson's disease (PD) for the treatment of motor fluctuations and dyskinesias. Here we describe 4 PD patients who developed disabling diphasic dyskinesias after LCIG initiation. METHODS: The clinical data of 33 PD patients consecutively treated with LCIG therapy were obtained through direct clinical observation and detailed review of medical records...
December 31, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28057951/stability-of-levodopa-carbidopa-rectal-suspensions
#4
Ronald F Donnelly
Objective: The combination of levodopa and carbidopa (L/C) is used as an effective therapy for treating Parkinson's disease; however when oropharyngeal dysphagia develops or when insertion of an nasogastric tube is not possible, then rectal administration could be used. To reduce compounding workload and establish a beyond use date, this study was conducted to determine the stability of 2 L/C rectal suspension formulations when stored at either 22°C or 5°C. Methods: Two formulations of L/C rectal suspension were compounded and then packaged in amber polypropylene bottles...
December 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/28053825/bioactive-flavonoids-and-catechols-as-hif1-and-nrf2-protein-stabilizers-implications-for-parkinson-s-disease
#5
Natalya A Smirnova, Navneet Ammal Kaidery, Dmitry M Hushpulian, Ilay I Rakhman, Andrey A Poloznikov, Vladimir I Tishkov, Saravanan S Karuppagounder, Irina N Gaisina, Anton Pekcec, Klaus Van Leyen, Sergey V Kazakov, Lichuan Yang, Bobby Thomas, Rajiv R Ratan, Irina G Gazaryan
Flavonoids are known to trigger the intrinsic genetic adaptive programs to hypoxic or oxidative stress via estrogen receptor engagement or upstream kinase activation. To reveal specific structural requirements for direct stabilization of the transcription factors responsible for triggering the antihypoxic and antioxidant programs, we studied flavones, isoflavones and catechols including dihydroxybenzoate, didox, levodopa, and nordihydroguaiaretic acid (NDGA), using novel luciferase-based reporters specific for the first step in HIF1 or Nrf2 protein stabilization...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28038867/parkinsonian-axial-signs-in-schizophrenia
#6
Francesca Morgante, Corrado Barbui, Michele Tinazzi
INTRODUCTION: We have recently demonstrated evidence of nigro-striatal denervation, disease progression and response to levodopa in a subgroup of patients with schizophrenia who developed parkinsonism. OBJECTIVE: In the present study, we investigated whether axial parkinsonian signs might be an early manifestation of parkinsonism in schizophrenia not necessarily related to chronic administration of antipsychotic drugs (AP) drugs. METHODS: From a baseline cohort of 299 schizophrenic patients who did not satisfy the diagnostic criteria for parkinsonism (presence of at least two of the following appendicular signs: bradykinesia, tremor, rigidity), we identified a group of patients who manifested two out of three axial parkinsonian signs (abnormality of trunk posture, hypomimia and short-step gait)...
December 23, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28038673/feature-visualization-and-classification-for-the-discrimination-between-individuals-with-parkinson-s-disease-under-levodopa-and-dbs-treatments
#7
Alessandro R P Machado, Hudson Capanema Zaidan, Ana Paula Souza Paixão, Guilherme Lopes Cavalheiro, Fábio Henrique Monteiro Oliveira, João Areis Ferreira Barbosa Júnior, Kheline Naves, Adriano Alves Pereira, Janser Moura Pereira, Nader Pouratian, Xiaoyi Zhuo, Andrew O'Keeffe, Justin Sharim, Yvette Bordelon, Laurice Yang, Marcus Fraga Vieira, Adriano O Andrade
BACKGROUND: Over the years, a number of distinct treatments have been adopted for the management of the motor symptoms of Parkinson's disease (PD), including pharmacologic therapies and deep brain stimulation (DBS). Efficacy is most often evaluated by subjective assessments, which are prone to error and dependent on the experience of the examiner. Our goal was to identify an objective means of assessing response to therapy. METHODS: In this study, we employed objective analyses in order to visualize and identify differences between three groups: healthy control (N = 10), subjects with PD treated with DBS (N = 12), and subjects with PD treated with levodopa (N = 16)...
December 30, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28029554/validation-of-the-italian-version-of-the-non-motor-symptoms-scale-for-parkinson-s-disease
#8
I Cova, M E Di Battista, N Vanacore, C P Papi, G Alampi, A Rubino, M Valente, G Meco, P Contri, A Di Pucchio, E Lacorte, A Priori, C Mariani, S Pomati
OBJECTIVE: To validate the adapted Italian version of the Non-Motor Symptoms Scale (NMSS), a tool to assess non-motor symptoms (NMS) in Parkinson's disease (PD). METHODS: A cross cultural adaptation of the NMSS into Italian and a psychometric analysis of the translated version of the NMSS was carried out in patients with PD from two university centres-affiliated hospitals. The quality of data and the acceptability, reliability and construct validity of NMSS were analyzed...
January 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28027332/opicapone-as-adjunct-to-levodopa-therapy-in-patients-with-parkinson-disease-and-motor-fluctuations-a-randomized-clinical-trial
#9
Andrew J Lees, Joaquim Ferreira, Olivier Rascol, Werner Poewe, José-Francisco Rocha, Michelle McCrory, Patricio Soares-da-Silva
Importance: Catechol O-methyltransferase (COMT) inhibitors are an established treatment for end-of-dose motor fluctuations associated with levodopa therapy in patients with Parkinson disease (PD). Current COMT inhibitors carry a high risk for toxic effects to hepatic cells or show moderate improvement. Opicapone was designed to be effective without the adverse effects. Objective: To evaluate the efficacy and safety of 25- and 50-mg/d dosages of opicapone compared with placebo as adjunct to levodopa therapy in patients with PD experiencing end-of-dose motor fluctuations...
December 27, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/28025945/double-blind-placebo-controlled-randomized-phase-i-iia-study-safety-and-efficacy-with-buspirone-levodopa-carbidopa-spinalontm-in-subjects-with-complete-ais-a-or-motor-complete-ais-b-spinal-cord-injury
#10
Mohan Radhakrishna, Inge Steuer, François Prince, Mary Roberts, David Mongeon, Maryam Kia, Sasha Dyck R N, Gilbert Matte, Mario Vaillancourt, Pierre A Guertin
BACKGROUND: No drug treatment capable of restoring locomotor capabilities in patients suffering a motor-complete spinal cord injury (SCI) has ever been developed. We assessed the safety and efficacy of an activator of spinal locomotor neurons in humans, which were shown in paraplegic animals to elicit temporary episodes of involuntary walking. METHODS: Single administration of buspirone/levodopa/carbidopa (Spinalon TM), levodopa/carbidopa (ratio 4: 1), and buspirone or placebo was performed using a dose-escalation design in 45 subjects placed in supine position who had had an SCI classified as complete (AIS A) or motor-complete/sensory incomplete (AIS B) for at least 3 months...
December 27, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28025665/mds-clinical-diagnostic-criteria-for-parkinson-s-disease-in-china
#11
Jun Li, Miao Jin, Li Wang, Bin Qin, Kang Wang
The Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's disease (MDS-PD Criteria) was introduced by the Movement Disorder Society in 2015 for research purposes. However, its use for clinical diagnosis of Parkinson disease still needs further revision. This study compares the UK-Criteria versus MDS-PD Criteria in the clinical diagnosis of Parkinson disease referred to the China-Japan Friendship Hospital of Beijing, China. To compare the MDS-PD Criteria with the UK-Criteria and discuss the feasibility of the clinical application of MDS-PD Criteria as a general guide to clinical diagnosis of PD in Chinese PD patients...
December 26, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/28024573/l-dopa-co-drugs-in-nanostructured-lipid-carriers-a-comparative-study
#12
Rita Cortesi, Elisabetta Esposito, Markus Drechsler, Gabriella Pavoni, Ivana Cacciatore, Maddalena Sguizzato, Antonio Di Stefano
This paper describes the production and characterization of nanostructured lipid carriers (NLC) containing four different levodopa (LD) co-drugs (PD), named PDA (3,4-diacetyloxy-LD-caffeic acid co-drug), PDB (lipoic acid-dopamine co-drug), PDC (lipoic acid-3,4-diacetoxy-dopamine co-drug), and PDD (dimeric LD co-drug containing an alkyl linker), with therapeutic potential in Parkinson's disease. These co-drugs were produced with the aim of prolonging the pharmacological activity of LD, enhancing its absorption and protecting it from metabolism...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28018168/what-mechanisms-are-responsible-for-the-reuptake-of-levodopa-derived-dopamine-in-parkinsonian-striatum
#13
REVIEW
Haruo Nishijima, Masahiko Tomiyama
Levodopa is the most effective medication for motor symptoms in Parkinson's disease. However, various motor and non-motor complications are associated with levodopa treatment, resulting from altered levodopa-dopamine metabolism with disease progression and long-term use of the drug. The present review emphasizes the role of monoamine transporters other than the dopamine transporter in uptake of extracellular dopamine in the dopamine-denervated striatum. When dopaminergic neurons are lost and dopamine transporters decreased, serotonin and norepinephrine transporters compensate by increasing uptake of excessive extracellular dopamine in the striatum...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28017533/re-emergent-tremor-in-parkinson-s-disease-clinical-and-accelerometric-properties
#14
Zübeyde Aytürk, Rezzak Yilmaz, M Cenk Akbostanci
Re-emergent tremor (RET) and the classical parkinsonian rest tremor were considered as two different phenomena of the same central tremor circuit. However, clinical and accelerometric characteristics of these tremors were not previously compared in a single study. We evaluated disease characteristics and accelerometric measurements of two tremor types in 42 patients with Parkinson's disease. Disease specific features and accelerometric measurements of peak frequency, amplitude at peak frequency and the root mean square (RMS) amplitude of two tremor types were compared...
December 22, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28012951/apomorphine-and-levodopa-in-parkinson-s-disease-two-revolutionary-drugs-from-the-1950-s
#15
Atbin Djamshidian, Werner Poewe
This article reviews the history of apomorphine and levodopa, which were both discovered in the 1950's and have revolutionized treatment paradigms of Parkinson's disease. Although the discovery of levodopa is a prime example of successful translation of basic neuroscience into clinical routine, the history of apomorphine was based on less solid evidence. Despite this, both drugs are, more than 6 decades after the first clinical experiments, still the two most efficacious medications to treat patients with Parkinson's disease...
December 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28004202/the-impact-of-early-versus-late-levodopa-administration
#16
Gilad Yahalom, Oren S Cohen, Naama Warmann-Alaluf, Chen Shabat, Hanna Strauss, Sandra Elincx-Benizri, Simon Israeli-Korn, Esther Stein, Lior Greenbaum, Sharon Hassin-Baer
Long-term levodopa therapy in patients with Parkinson's disease (PD) is associated with motor complications including motor fluctuations (MF) and levodopa-induced dyskinesias (LID). The time to appearance of MF and LID is apparently related to both the timing and the duration of levodopa therapy, but is highly variable. We performed a retrospective analysis of all levodopa-treated PD patients to explore the effect of time from PD onset to levodopa initiation on time to MF or LID. We used a Cox multivariate regression model after stratifying patients into four quartiles, according to the time to levodopa initiation...
December 21, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27998652/the-need-for-non-oral-therapy-in-parkinson-s-disease-a-potential-role-for-apomorphine
#17
Teus van Laar, Robbert Borgemeester
In the course of Parkinson's disease (PD), oral medication may lose its effectiveness due to several reasons, like dysphagia, impaired absorption from the gastro-intestinal tract and delayed emptying of the stomach. If these problems occur, a non-oral therapy should be considered. Examples of non-oral therapies are transdermal patches, (e.g. rotigotine) which may overcome motor and nonmotor nighttime problems, and may serve as well to treat daytime response-fluctuations, if oral therapies fail to do so. Other options are injections with apomorphine to treat early morning dystonia and random off-periods during daytime, as well as continuously infused subcutaneous apomorphine for random fluctuations in PD patients...
December 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27994352/assessment-of-fatigue-in-parkinson-s-disease-indian-perspective
#18
Birinder Singh Paul, Amandeep Singh, Dinesh Jain, Gagandeep Singh, Sandeep Kaushal, Gunchan Paul, Karan Kaura
CONTEXT: Fatigue is one of the most frequent nonmotor manifestations in Parkinson's disease (PD), having a major effect on quality of life but is not reported in Indian patients. AIMS: To evaluate the frequency of fatigue in a cohort of PD population and its correlation with disease. SETTINGS AND DESIGN: Fatigue Severity Scale (FSS) was translated and validated in local vernacular language. All patients of PD visiting neurology outpatient department of a tertiary care hospital...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27990316/subthalamus-stimulation-in-parkinson-disease-accounting-for-the-bilaterality-of-contacts
#19
Jean-Jacques Lemaire, Bruno Pereira, Philippe Derost, François Vassal, Miguel Ulla, Dominique Morand, Guillaume Coll, Jean Gabrillargues, Ana Marques, Bérangère Debilly, Jérôme Coste, Franck Durif
BACKGROUND: Deep brain stimulation (DBS) in Parkinson's disease uses bi-hemispheric high-frequency stimulation within the subthalamus, however, the specific impacts of bilaterality of DBS are still not clear. Thus, we aimed to study the individual-level clinical impact of locations of right-left contact pair-up accounting for each subthalamic nucleus (STN) anatomy. METHODS: Contact locations and effects at 1 year were studied retrospectively in an unselected series of 53 patients operated between 2004 and 2010...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27987231/levodopa-entacapone-carbidopa-intestinal-gel-in-parkinson-s-disease-a-randomized-crossover-study
#20
Marina Senek, Elisabet I Nielsen, Dag Nyholm
BACKGROUND: The addition of oral entacapone to levodopa-carbidopa intestinal gel treatment leads to less conversion of levodopa to 3-O-methyldopa, thereby increasing levodopa plasma concentration. The objective of this study was to compare systemic levodopa exposure of the newly developed levodopa-entacapone-carbidopa intestinal gel after a 20% dose reduction with levodopa exposure after the usual levodopa-carbidopa intestinal gel dose in a randomized crossover trial in advanced Parkinson's disease patients...
December 17, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
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