Shenzhen Huang, Wenxiao Zhang, Shuting Xuan, Hongli Si, Duliurui Huang, Mengru Ba, Di Qi, Xiaoting Pei, Dingli Lu, Zhijie Li
Sleep loss is common in modern society and is increasingly associated with eye diseases. However, the precise effects of sleep loss on retinal structure and function, particularly on the retinal circadian system, remain largely unexplored. This study investigates these effects using a chronic sleep deprivation (CSD) model in mice. Our investigation reveals that CSD significantly alters the retinal circadian transcriptome, leading to remarkable changes in the temporal patterns of enriched pathways. This perturbation extends to metabolic and immune-related transcriptomes, coupled with an accumulation of reactive oxygen species in the retina...
April 20, 2024: Experimental Eye Research