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Propensity analysis

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https://www.readbyqxmd.com/read/28350831/post-term-growth-and-cognitive-development-at-5-years-of-age-in-preterm-children-evidence-from-a-prospective-population-based-cohort
#1
Laure Simon, Simon Nusinovici, Cyril Flamant, Bertrand Cariou, Valérie Rouger, Géraldine Gascoin, Dominique Darmaun, Jean-Christophe Rozé, Matthieu Hanf
While the effects of growth from birth to expected term on the subsequent development of preterm children has attracted plentiful attention, less is known about the effects of post-term growth. We aimed to delineate distinct patterns of post-term growth and to determine their association with the cognitive development of preterm children. Data from a prospective population-based cohort of 3,850 surviving infants born at less than 35 weeks of gestational age were used. Growth was assessed as the Body Mass Index (BMI) Z-scores at 3, 9, 18, 24, 36, 48, and 60 months...
2017: PloS One
https://www.readbyqxmd.com/read/28350568/reducing-length-of-stay-using-a-robotic-assisted-approach-for-retromuscular-ventral-hernia-repair-a-comparative-analysis-from-the-americas-hernia-society-quality-collaborative
#2
Alfredo M Carbonell, Jeremy A Warren, Ajita S Prabhu, Conrad D Ballecer, Randy J Janczyk, Javier Herrera, Li-Ching Huang, Sharon Phillips, Michael J Rosen, Benjamin K Poulose
OBJECTIVE: The aim of this study was to compare length of stay (LOS) after robotic-assisted and open retromuscular ventral hernia repair (RVHR). BACKGROUND: RVHR has traditionally been performed by open techniques. Robotic-assisted surgery enables surgeons to perform minimally invasive RVHR, but with unknown benefit. Using real-world evidence, this study compared LOS after open (o-RVHR) and robotic-assisted (r-RVHR) approach. METHODS: Multi-institutional data from patients undergoing elective RVHR in the Americas Hernia Society Quality Collaborative between 2013 and 2016 were analyzed...
March 27, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28350440/identification-of-trypanosoma-brucei-adometdc-inhibitors-using-a-high-throughput-mass-spectrometry-based-assay
#3
Oleg A Volkov, Casey C Cosner, Anthony J Brockway, Martin Kramer, Michael Booker, Shihua Zhong, Ariel Ketcherside, Shuguang Wei, Jamie Longgood, Melissa K McCoy, Thomas E Richardson, Stephen A Wring, Michael Peel, Jeffrey D Klinger, Bruce A Posner, Jef K De Brabander, Margaret A Phillips
Human African trypanosomiasis (HAT) is a fatal infectious disease caused by the eukaryotic pathogen Trypanosoma brucei. Available treatments are difficult to administer and have significant safety issues. S-Adenosylmethionine decarboxylase (AdoMetDC) is an essential enzyme in the parasite polyamine biosynthetic pathway. Previous attempts to develop TbAdoMetDC inhibitors into anti-HAT therapies failed due to poor brain exposure. Here, we describe a large screening campaign of two small-molecule libraries (~400,000 compounds) employing a new high-throughput (~7 s per sample) mass spectrometry-based assay for AdoMetDC activity...
March 28, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28346261/advantages-of-minimal-access-versus-conventional-aortic-valve-replacement-in-elderly-or-severely-obese-patients
#4
Calogera Pisano, Pasquale Totaro, Oreste Fabio Triolo, Vincenzo Argano
OBJECTIVE: The aim of our study was to investigate potential clinical advantages of minimal access versus conventional surgical approach in older and severely obese patients undergoing isolated aortic valve replacement (AVR). METHODS: One hundred thirty-five patients undergoing isolated primary AVR were enrolled. Propensity score matching was used to compare 42 selected patients operated on ministernotomy (MS, group B) with 42 selected patients operated on full sternotomy (FS, group A)...
March 25, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/28345442/predicting-1-year-statin-adherence-among-prevalent-users-a-retrospective-cohort-study
#5
Alexis A Krumme, Jessica M Franklin, Danielle L Isaman, Olga S Matlin, Angela Y Tong, Claire M Spettell, Troyen A Brennan, William H Shrank, Niteesh K Choudhry
BACKGROUND: Attempts to predict who is at risk of future nonadherence have largely focused on predictions at the time of therapy initiation; however, these users are only a small proportion of all patients on therapy at any point in time. Methods to predict nonadherence for established medication users, which have not been previously described in the literature, would be helpful to guide efforts to enhance the use of evidence-based therapies. OBJECTIVE: To test approaches for adherence prediction among prevalent statin users, namely the use of short-term filling behavior, investigator-specified predictors from medical and pharmacy administrative claims, and the empirical selection of potential predictors using the high-dimensional propensity score variable selection algorithm...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28345441/prevalence-and-cost-of-subsequent-fractures-among-u-s-patients-with-an-incident-fracture
#6
Jessica Weaver, Shiva Sajjan, E Michael Lewiecki, Steven T Harris, Panagiotis Marvos
BACKGROUND: The prevalence and cost of subsequent fractures among patients with an incident fracture are not well defined. OBJECTIVE: To assess the prevalence of, and costs associated with, subsequent fractures in the year after an incident fracture. METHODS: This was a retrospective claims database analysis using data from Humana Medicare Advantage claims (Medicare group) and Optum Insight Clinformatics Data Mart commercial claims (commercial group)...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28345440/the-economic-burden-of-opioid-abuse-updated-findings
#7
Noam Y Kirson, Lauren M Scarpati, Caroline J Enloe, Aliya P Dincer, Howard G Birnbaum, Tracy J Mayne
BACKGROUND: Opioid pain relievers can be highly effective in providing relief for patients suffering from pain. At the same time, prescription opioid abuse, dependence, overdose, and poisoning (hereinafter "abuse") have become a national public health concern. Opioid abuse is also costly: previous estimates of the annual excess costs of opioid abuse to payers range from approximately $10,000 to $20,000 per patient. OBJECTIVES: To (a) provide a comprehensive, current estimate of the economic burden of opioid abuse to commercial payers and (b) explore the drivers of these excess costs of abuse...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28345361/implant-of-permanent-pacemaker-during-acute-coronary-syndrome-mortality-and-associated-factors-in-the-ariam-registry
#8
María Dolores Pola-Gallego-de-Guzmán, Manuel Ruiz-Bailén, Maria-Angeles Martínez-Arcos, Artur Gómez-Blizniak, Ana-Maria Castillo Rivera, Jesus Cobo Molinos
BACKGROUND: Patients with acute coronary syndrome complicated with high degree atrioventricular block still have a high mortality. A low percentage of these patients need a permanent pacemaker (PPM) but mortality and associated factors with the PPM implant in acute coronary syndrome patients are not known. We assess whether PPM implant is an independent variable in the mortality of acute coronary syndrome patients. Also, we explored the variables that remain independently associated with PPM implantation...
March 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28344883/acquisition-of-tumor-cell-phenotypic-diversity-along-the-emt-spectrum-under-hypoxic-pressure-consequences-on-susceptibility-to-cell-mediated-cytotoxicity
#9
Stéphane Terry, Stéphanie Buart, Tuan Zea Tan, Gwendoline Gros, Muhammad Zaeem Noman, James B Lorens, Fathia Mami-Chouaib, Jean Paul Thiery, Salem Chouaib
Tumor escape to immunosurveillance and resistance to immune attacks present a major hurdle in cancer therapy, especially in the current era of new cancer immunotherapies. We report here that hypoxia, a hallmark of most solid tumors, orchestrates carcinoma cell heterogeneity through the induction of phenotypic diversity and the acquisition of distinct epithelial-mesenchymal transition (EMT) states. Using lung adenocarcinoma cells derived from a non-metastatic patient, we demonstrated that hypoxic stress induced phenotypic diversity along the EMT spectrum, with induction of EMT transcription factors (EMT-TFs) SNAI1, SNAI2, TWIST1, and ZEB2 in a hypoxia-inducible factor-1α (HIF1A)-dependent or -independent manner...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28344019/open-versus-minimally-invasive-surgical-approaches-in-pediatric-urology-trends-in-utilization-and-complications
#10
Rohit Tejwani, Brian J Young, Hsin-Hsiao S Wang, Steven Wolf, J Todd Purves, John S Wiener, Jonathan C Routh
OBJECTIVE: Minimally invasive surgery (MIS) techniques are anecdotally reported to be increasingly used, but little objective data supports this. Our objective was to assess trends in MIS utilization across various procedures in pediatric urology and to compare postoperative complication rates between MIS and open procedures. METHODS: We analyzed the 1998-2012 Nationwide Inpatient Sample. We identified children (<18 years old) undergoing open and MIS inpatient procedures and any in-hospital post-operative complications that occurred during that postoperative hospitalization...
February 22, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28343391/single-molecule-peptide-lipid-affinity-assay-reveals-interplay-between-solution-structure-and-partitioning
#11
Tina R Matin, Krishna P Sigdel, Milica Utjesanovic, Brendan P Marsh, Fabio Gallazzi, Virginia F Smith, Ioan Kosztin, Gavin M King
Interactions between short protein segments and phospholipid bilayers dictate fundamental aspects of cellular activity and have important applications in biotechnology. Yet, a lack of suitable methodology for directly probing these interactions has hindered mechanistic understanding. We developed a precision atomic force microscope (AFM)-based single-molecule force spectroscopy assay and probed partitioning into lipid bilayers by measuring the mechanical force experienced by a peptide. Protein segments were constructed from the peripheral membrane protein SecA, a key ATPase in bacterial secretion...
March 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28342947/what-good-are-positive-emotions-for-treatment-trait-positive-emotionality-predicts-response-to-cognitive-behavioral-therapy-for-anxiety
#12
Charles T Taylor, Sarah E Knapp, Jessica A Bomyea, Holly J Ramsawh, Martin P Paulus, Murray B Stein
OBJECTIVE: Cognitive behavioral therapy (CBT) is empirically supported for the treatment of anxiety disorders; however, not all individuals achieve recovery following CBT. Positive emotions serve a number of functions that theoretically should facilitate response to CBT - they promote flexible patterns of information processing and assimilation of new information, encourage approach-oriented behavior, and speed physiological recovery from negative emotions. We conducted a secondary analysis of an existing clinical trial dataset to test the a priori hypothesis that individual differences in trait positive emotions would predict CBT response for anxiety...
March 22, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28342542/determinants-of-late-tricuspid-regurgitation-after-aortic-mitral-double-valve-replacement
#13
Dong Seop Jeong, Pyo Won Park, Kiick Sung, Wook Sung Kim, Young Tak Lee
The aims of this study are to evaluate the long-term outcomes of double valve replacement (aortic and mitral valves) and to investigate the determinants of late tricuspid regurgitation (TR). A total of 239 consecutive patients who underwent double valve replacement were enrolled. Valve pathology was rheumatic in 86.6% (207/239) and degenerative in 13.4% (32/239) of patients. Among these patients, 116 patients underwent concomitant tricuspid annuloplasty, and follow-up was completed for all 239 patients (mean = 7...
March 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28342097/a-systematic-review-of-propensity-score-methods-in-the-acute-care-surgery-literature-avoiding-the-pitfalls-and-proposing-a-set-of-reporting-guidelines
#14
T L Zakrison, P C Austin, V A McCredie
BACKGROUND: Propensity score methods are techniques commonly employed in observational research to account for confounding when estimating the effects of treatments and exposures. These methods have been increasingly employed in the acute care surgery literature in an attempt to infer causality; however, the adequacy of reporting and the appropriateness of statistical analyses when using propensity score matching remain unclear. OBJECTIVES: The goal of this systematic review is to assess the adequacy of reporting of propensity score methods, with an emphasis on propensity score matching (to assess balance and the use of appropriate statistical tests), in acute care surgery (ACS) studies and to provide suggestions for improvement for junior investigators...
March 24, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28341513/impact-of-inferior-vena-cava-filter-placement-on-short-term-outcomes-in-patients-with-acute-pulmonary-embolism
#15
Nathan L Liang, Elizabeth A Genovese, Efthymios D Avgerinos, Michael J Singh, Michel S Makaroun, Rabih A Chaer
BACKGROUND: Inferior vena cava filters (IVCF) have been associated with improved survival in patients with acute pulmonary embolism (PE) in some studies. However, without randomization, those with early mortality who did not receive an IVCF may have died prior to treatment decision about filter placement, falsely contributing a survival advantage to those receiving IVCF and biasing the results of previous observational studies. The objective of this study is to evaluate the impact of IVCF on in-hospital mortality after adjusting for this survivor treatment selection...
March 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28341441/neoadjuvant-therapy-versus-upfront-surgery-for-resected-pancreatic-adenocarcinoma-a-nationwide-propensity-score-matched-analysis
#16
Susanna W L de Geus, Mariam F Eskander, Lindsay A Bliss, Gyulnara G Kasumova, Sing Chau Ng, Mark P Callery, Jennifer F Tseng
BACKGROUND: Neoadjuvant therapy is an emerging paradigm in pancreatic cancer care; however, its role for resectable disease remains controversial in the absence of conclusive randomized controlled trials. The purpose of the present study is to assess the impact of neoadjuvant therapy on survival in resected pancreatic cancer patients by clinical stage. METHODS: A retrospective cohort study using the National Cancer Data Base from 2004 to 2012 including nonmetastatic pancreatic adenocarcinoma patients who underwent pancreatectomy and initiated chemotherapy...
March 2017: Surgery
https://www.readbyqxmd.com/read/28341362/sinus-bradycardia-in-habitual-cocaine-users
#17
Sona M Franklin, Sudarone Thihalolipavan, John M Fontaine
Common physiological manifestations of cocaine are related to its adrenergic effects, due to inhibition of dopamine and norepinephrine uptake at the postsynaptic terminal. Few studies have documented bradycardia secondary to cocaine use, representing the antithesis of its adrenergic effects. We assessed the prevalence of sinus bradycardia (SB) in habitual cocaine users and postulated a mechanism for this effect. One hundred sixty-two patients with a history of cocaine use were analyzed and compared with age- and gender-matched controls...
March 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28341354/comparison-of-propensity-score-matched-analysis-of-acute-kidney-injury-after-percutaneous-coronary-intervention-with-transradial-versus-transfemoral-approaches
#18
Arie Steinvil, Hector M Garcia-Garcia, Toby Rogers, Eddie Koifman, Kyle Buchanan, M Chadi Alraies, Rebecca Torguson, Augusto D Pichard, Lowell F Satler, Itsik Ben-Dor, Ron Waksman
Transradial percutaneous coronary intervention (TR-PCI) may be associated with reduced rates of acute kidney injury (AKI). There is limited data from real-world registries about AKI rates stratified by PCI access. Our aim was to evaluate AKI rates and correlates in TR-PCI versus transfemoral PCI (TF-PCI) in a propensity score-matched analysis of patient data from a large, single-center registry. We performed a 1:1 propensity score-matched analysis on consecutive patients who underwent PCI from January 2011 to June 2016, excluding those on dialysis...
February 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28341194/outcomes-of-open-staged-corrective-surgery-in-the-setting-of-adult-spinal-deformity
#19
Peter G Passias, Gregory W Poorman, Cyrus M Jalai, Breton Line, Bassel Diebo, Paul Park, Robert Hart, Douglas Burton, Frank Schwab, Virginie Lafage, Shay Bess, Thomas Errico
BACKGROUND CONTEXT: Adult spinal deformity (ASD) represents a constellation of complex mal-alignments affecting the spinal column. Corrective surgical procedures aimed at improving ASD can be equally challenging, and commonly require multiple index procedures and potential revisions prior to definitive management. There is a paucity of data comparing the outcomes of same-day (simultaneous) and two-day (staged) procedures for long spinal-fusions for ASD. Utilizing a large patient cohort with surgeon and patient-reported outcomes will be particularly useful in determining the utility and effect of staging long spine fusions for ASD...
March 21, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28341062/the-effect-of-post-mastectomy-radiation-in-women-with-one-to-three-positive-nodes-enrolled-on-the-control-arm-of-bcirg-005-at-ten-year-follow-up
#20
Moses M Tam, S Peter Wu, Carmen Perez, Naamit Kurshan Gerber
BACKGROUND AND PURPOSE: We evaluated the effect of post-mastectomy radiation (PMRT) in 1-3 positive lymph nodes (LN) in patients who received uniform modern systemic therapy. MATERIALS AND METHODS: Cohort study using individual data collected for 1,649 node-positive women who received doxorubicin/cyclophosphamide with sequential docetaxel in 2000-2003 on the control arm of BCIRG-005. All women underwent mastectomy or lumpectomy and axillary LN dissection. PMRT was given at investigator's discretion...
March 22, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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