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https://www.readbyqxmd.com/read/28890009/impact-of-onyx%C3%A2-embolization-on-radiosurgical-management-of-cerebral-avm-treatment-and-outcome
#1
Ido Strauss, Oz Haim, Daniel Umansky, Benjamin W Corn, Vladimir Frolov, Natan Shtraus, Shimon Maimon, Andrew A Kanner
BACKGROUND: Stereotactic radiosurgery (SRS) is a well-established treatment modality for cerebral arterio-venous malformations (AVMs). The main limiting factor in the radiosurgical treatment of AVMs is the volume of the nidus with high-grade lesions often requiring combined treatment to reduce the SRS target volume. To overcome this limitation, we have been using a combined treatment approach consisting of endovascular embolization with ONYX followed by SRS. OBJECTIVE: To evaluate our clinical experience for safety and feasibility of this multimodality treatment approach...
September 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28882716/remote-thoracic-myelopathy-from-a-spinal-dural-arteriovenous-fistula-at-the-cranio-cervical-junction-case-report-and-review-of-literature
#2
Michael J Lang, Stavropoula Tjoumakaris, Robert H Rosenwasser, Pascal Jabbour
BACKGROUND: The cranio-cervical junction is a rare location for spinal dural arteriovenous fistulas (dAVF). Typically, fistulas at this location present with findings related to intracranial cortical venous reflux or with cervical myelopathy. We present a case of cranio-cervical junction dAVF with isolated clinical and radiographic findings of thoracolumbar myelopathy. CASE DESCRIPTION: A 54 year-old male presented with subacute onset of lower extremity weakness, paresthesias and gait dysfunction...
September 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28843768/carfilzomib-or-bortezomib-in-relapsed-or-refractory-multiple-myeloma-endeavor-an-interim-overall-survival-analysis-of-an-open-label-randomised-phase-3-trial
#3
Meletios A Dimopoulos, Hartmut Goldschmidt, Ruben Niesvizky, Douglas Joshua, Wee-Joo Chng, Albert Oriol, Robert Z Orlowski, Heinz Ludwig, Thierry Facon, Roman Hajek, Katja Weisel, Vania Hungria, Leonard Minuk, Shibao Feng, Anita Zahlten-Kumeli, Amy S Kimball, Philippe Moreau
BACKGROUND: The phase 3 ENDEAVOR trial was a head-to-head comparison of two proteasome inhibitors in patients with relapsed or refractory multiple myeloma. Progression-free survival was previously reported to be significantly longer with carfilzomib administered in combination with dexamethasone than with bortezomib and dexamethasone in an interim analysis. The aim of this second interim analysis was to compare overall survival between the two treatment groups. METHODS: ENDEAVOR was a phase 3, open-label, randomised controlled trial in patients with relapsed or refractory multiple myeloma...
August 23, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28840070/embolization-of-a-spinal-dural-arteriovenous-fistula-with-ethylene-vinyl-alcohol-copolymer-onyx-using-a-dual-lumen-microballoon-catheter-and-buddy-wire-technique
#4
Ryuta Nakae, Masaya Nagaishi, Akio Hyodo, Kensuke Suzuki
BACKGROUND: N-butyl 2-cyanoacrylate (NBCA) remains the standard embolic agent for spinal dural arteriovenous fistula (SDAVF) treatment. Treatment of SDAVF with ethylene-vinyl alcohol copolymer (Onyx, ev3-Covidien, Irvine CA, USA) is currently not well established. Although several cases have reported the use of Onyx to embolize an intracranial dural arteriovenous fistula using a dual-lumen microballoon catheter, Onyx embolization of an SDAVF using a dual-lumen microballoon catheter has not been reported...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28838879/transvenous-endovascular-treatment-for-scalp-arteriovenous-fistulas-results-with-combined-use-of-onyx-and-coils
#5
Wei Ni, Yanlong Tian, Yuxiang Gu, Ying Mao
OBJECT: Scalp arteriovenous fistulas (AVFs) are rare lesions and may occur spontaneously or secondary to head trauma. The standard treating strategy for these lesions has not been established to date. We present three cases of successful treatment of scalp AVFs using a combination of Onyx-18 and coils via a transvenous approach. METHODS: The database of patients at Huashan Hospital, Fudan University, Shanghai, China was reviewed. The patients with scalp AVFs treated with Onyx-18 and coils via a transvenous approach were included...
August 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28819591/aggressive-vertebral-body-hemangioma-causing-compressive-myelopathy-two-case-reports
#6
Denver Steven Pinto, V Ravi Hoisala, Pavan Gupta, Parthasarathy Sarkar
INTRODUCTION: Hemangiomas are benign tumors characterized by proliferation of blood vessels. A few hemangiomas are aggressive, characterized by bone expansion and extraosseous extension. These benign tumors may be mistaken for metatasis resulting in unnecessary biopsies, which have a high risk of hemorrhage. These hemangiomas can spread not just into the paraspinal soft tissues but also into the epidural region of the spinal canal causing cord compression and paraparesis. These clinical symptoms can be relieved by surgical decompression of the posterior elements, embolization or radiotherapy...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28818827/endovascular-treatment-of-dural-arteriovenous-fistulas-of-the-transverse-and-sigmoid-sinuses-using-transarterial-balloon-assisted-embolization-combined-with-transvenous-balloon-protection-of-the-venous-sinus
#7
E Piechowiak, F Zibold, T Dobrocky, P J Mosimann, D Bervini, A Raabe, J Gralla, P Mordasini
BACKGROUND AND PURPOSE: Combined transarterial balloon-assisted endovascular embolization with double-lumen balloon microcatheters and concomitant transvenous balloon protection was described as a promising treatment technique for dural arteriovenous fistulae of the transverse and sigmoid sinus. The purpose of this study was to evaluate the technical efficacy and safety of this combined treatment technique. MATERIALS AND METHODS: Nine consecutive patients presenting with dural arteriovenous fistulas of the transverse and sigmoid sinuses underwent combined transarterial and transvenous balloon-assisted endovascular embolization...
August 17, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28801711/safety-of-onyx-transarterial-embolization-of-skull-base-dural-arteriovenous-fistulas-from-meningeal-branches-of-the-external-carotids-also-fed-by-meningeal-branches-of-internal-carotid-or-vertebral-arteries
#8
Thiago G Abud, Emmanuel Houdart, Jean-Pierre Saint-Maurice, Daniel G Abud, Carlos E Baccin, Andrew D Nguyen, Nitamar Abdala
PURPOSE: To analyze the angiographic and clinical results of transarterial embolization with Onyx (Medtronic-Covidien, Irvine, CA) in dural arteriovenous fistulas (DAVFs) partially fed by arteries arising from the carotid siphon or the vertebral arteries. METHODS: We isolated 40 DAVFs supplied by either the tentorial artery of the internal carotid artery (ICA) or the posterior meningeal artery of the vertebral artery. These DAVFs were embolized with Onyx through the middle meningeal artery or the occipital artery...
August 11, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28758853/one-year-clinical-outcomes-of-patients-implanted-with-a-resolute-onyx%C3%A2-zotarolimus-eluting-stent
#9
Chor Cheung Tam, Kelvin Chan, Simon Lam, Arthur Yung, Yui Ming Lam, Carmen Chan, David Siu, Hung Fat Tse
Objective To evaluate the 1-year clinical outcomes of patients who received the Resolute Onyx™ stent. Methods This was a single-centre, retrospective registry analysis that reviewed the clinical data from all patients who were implanted with a Resolute Onyx™ stent between March 2015 and February 2016. Clinical follow-up was performed at 1 year post-implantation. Results A total of 252 patients received a Resolute Onyx™ stent and two patients were lost to follow-up. The mean age of the cohort was 66.9 years and 113 (45...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28739568/posterior-meningeal-artery-dmso-injection-resulting-in-reproducible-asystole-prior-to-onyx-therapy-of-a-dural-arteriovenous-fistula-a-previously-undescribed-variant-of-the-trigeminocardiac-reflex-or-a-new-phenomenon
#10
Matthew Thomas Crockett, Anthony Ernest Robinson, Harmeet Aneja, Timothy John Phillips
We describe a case of reproducible asystole during endovascular treatment of a posterior fossa dural arteriovenous fistula. Catheterisation of the posterior meningeal artery, a branch of the vertebral artery in this patient, followed by dimethyl sulfoxide injection prior to Onyx administration resulted in two episodes of asystole.To the best of our knowledge, this is the first reported case of asystole occurring during endovascular intervention in the posterior meningeal artery. This may represent a previously undescribed variant of the trigemino-cardiac reflex (TGCR) caused by chemical stimulation of small areas of trigeminally innervated posterior fossa dura...
July 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28728650/first-report-of-the-resolute-onyx-2-0-mm%C3%A2-zotarolimus-eluting-stent-for-the-treatment-of-coronary-lesions-with-very%C3%A2-small-reference-vessel-diameter
#11
Matthew J Price, Shigeru Saito, Richard A Shlofmitz, Douglas J Spriggs, Michael Attubato, Brent McLaurin, Alexandra Popma Almonacid, Sandeep Brar, Minglei Liu, Elizabeth Moe, Roxana Mehran
OBJECTIVES: The aim of this study was to explore the safety and efficacy of a dedicated drug-eluting stent for the treatment of coronary lesions with very small reference vessel diameter (RVD). BACKGROUND: Smaller RVD is associated with increased risk for restenosis and target lesion failure (TLF) after stent implantation. METHODS: This was a prospective, single-arm, multicenter trial of the Resolute Onyx 2.0-mm zotarolimus-eluting stent. The primary endpoint was 12-month TLF, which was compared with a pre-specified performance goal...
July 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28711532/an-intraoperative-look-at-a-residual-recurrent-tentorial-dural-arteriovenous-fistula
#12
Bradley A Gross, Andrew F Ducruet, Brian T Jankowitz, Paul A Gardner
BACKGROUND: Dural arteriovenous fistulas (dAVFs) often are treated via transarterial or transvenous embolization. Incomplete penetration of the draining vein/occult residual often will become apparent on follow-up angiography, requiring repeat embolization, or at times, surgical resection. CASE DESCRIPTION: A 41-year-old woman presented with cerebellar hemorrhage from a tentorial dAVF treated with transvenous coil embolization. Follow-up angiography disclosed a residual/recurrent fistula treated with transvenous Onyx embolization...
September 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28710086/onyx-embolization-prior-to-stereotactic-radiosurgery-for-brain-arteriovenous-malformations-a-single-center-treatment-algorithm
#13
John D Nerva, Jason Barber, Michael R Levitt, Jason K Rockhill, Danial K Hallam, Basavaraj V Ghodke, Laligam N Sekhar, Louis J Kim
BACKGROUND: Embolization before stereotactic radiosurgery (SRS) for brain arteriovenous malformations (BAVMs) is controversial. OBJECTIVE: To compare clinical and radiographic outcomes in patients undergoing pre-SRS embolization with ethylene copolymer (Onyx) with outcomes in patients undergoing SRS alone. METHODS: Seventy consecutive patients with BAVMs who underwent SRS were retrospectively reviewed. Univariate and multivariate analyses were performed to assess the factors associated with radiographic obliteration and complication...
July 14, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28702115/staged-arterial-and-venous-embolizations-in-treatment-of-type-iv-intraosseous-dural-arteriovenous-fistula
#14
Aleksandra V Betcher, Andrew W Schnure, Paul H Janda, Rajneesh Agrawal, Amandeep Dhillon
OBJECTIVE: This is a case report of an adult male with complex type IV intraosseous DAVF causing severe venous hypertension and bony destruction, presenting with severe hemotympanum, and a novel way of staged arterial and venous embolizations to treat the emergent symptoms. METHODS: First and second stages were direct selective arterial embolizations using Onyx liquid agent. Goal was to reduce flow into the fistula by embolizing the feeder branch and distal penetration of the nidus with Onyx...
June 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/28689342/superselective-transvenous-embolization-with-onyx-and-n-bca-for-vein-of-galen-aneurysmal-malformations-with-restricted-transarterial-access-safety-efficacy-and-technical-aspects
#15
Kirill Orlov, Anton Gorbatykh, Vadim Berestov, Timur Shayakhmetov, Dmitry Kislitsin, Pavel Seleznev, Nikolay Strelnikov
PURPOSE AND METHODS: Superselective transvenous embolization (TVE) with liquid embolic agents is a new concept in treatment of vein of Galen aneurysmal malformations (VGAM). We performed ten sessions of TVE in VGAM patients with restricted transarterial access. In this paper, we assessed clinical and angiographic outcomes of the proposed treatment and discussed three different TVE techniques with regard to morphology of the shunt and outflow tract. Safety and avoidance-of-complication tips were also discussed...
July 8, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28689184/evaluation-of-a-novel-liquid-embolic-agent-precipitating-hydrophobic-injectable-liquid-phil-in-an-animal-endovascular-embolization-model
#16
Dominik F Vollherbst, Ruth Otto, Andreas von Deimling, Johannes Pfaff, Christian Ulfert, Hans U Kauczor, Martin Bendszus, Christof M Sommer, Markus A Möhlenbruch
BACKGROUND: The choice of the embolic agent and the embolization technique can have a significant impact on the success of endovascular embolization. OBJECTIVE: To evaluate a novel iodinated copolymer-based liquid embolic agent (precipitating hydrophobic injectable liquid (PHIL)) in the porcine rete mirabile (RM), serving as an endovascular embolization model. Onyx, as an established liquid embolic agent, served as comparator. MATERIALS AND METHODS: Sixteen embolization procedures were performed using PHIL (n=8) or Onyx (n=8) as liquid embolic agent...
July 8, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28675345/transvenous-retrograde-avm-embolization-indications-techniques-complications-and-outcomes
#17
Xianli Lv, Cao Song, Hongwei He, Chuhan Jiang, Youxiang Li
Objective Transvenous retrograde arteriovenous malformation (AVM) embolization (TRAE) has been proposed. The present study was to review the techniques, their conjunctions and effectiveness. Methods Eligible related articles were identified by searching the PubMed and Web of Science databases using "transvenous" and "arteriovenous malformation." Results A total of 16 eligible studies, with 60 cases of AVM treated with TRAE, were analyzed. Prior to TRAE procedure, transarterial Onyx 18 was performed in 23 (38...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28669270/selective-embolization-of-ruptured-feeding-artery-aneurysm-followed-by-resection-of-arteriovenous-malformation
#18
Brian P Walcott, Jonathan J Russin, Robin Babadjouni, William J Mack
This is the case of a man in his 40s who suffered sudden collapse into a deep coma as a result of a ruptured arteriovenous malformation (AVM) feeding artery aneurysm within the lateral ventricle. The ruptured aneurysm was successfully treated with Onyx embolization of the feeding pedicle. The AVM and the feeding artery aneurysm were then removed via a transcallosal approach. This case highlights the utility of interrogating the AVM with microcatheterization of the feeding pedicles in order to define the exact anatomical features necessary for treatment planning...
July 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28647659/flow-diverters-as-useful-adjunct-to-traditional-endovascular-techniques-in-treatment-of-direct-carotid-cavernous-fistulas
#19
Christopher S Ogilvy, Rouzbeh Motiei-Langroudi, Mohammad Ghorbani, Christoph J Griessenauer, Abdulrahman Y Alturki, Ajith J Thomas
BACKGROUND: Direct carotid-cavernous sinus fistulas (CCFs) are high-flow arteriovenous shunts that are typically the result of a severe head injury. The endovascular treatment of these lesions includes the use of detachable balloons, coils, liquid embolic agents, and covered stents. To minimize the chance of treatment failure and subsequent complications, endoluminal reconstruction using a flow-diverting stent may be added to the treatment construct. METHODS: We present 3 cases and review the existing literature...
September 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28647478/embolization-of-ovarian-vein-for-pelvic-congestion-syndrome-with-ethylene-vinyl-alcohol-copolymer-onyx-%C3%A2
#20
C Marcelin, J Izaaryene, M Castelli, P A Barral, A Jacquier, V Vidal, J M Bartoli
PURPOSE: To evaluate the safety and efficacy of pelvic embolization using ethylene vinyl alcohol copolymer (Onyx(®)) for pelvic congestion syndrome. MATERIAL AND METHODS: Between March 2012 to September 2016, 17 women (mean age, 44.7± 12.2 (SD) years; range: 34-71years) presenting with pelvic congestion syndrome were evaluated for transvenous embolization with Onyx(®). Pelvic congestion syndrome was initially diagnosed by clinical examination and the results of transvaginal Doppler ultrasound and further confirmed by pelvic venography...
June 21, 2017: Diagnostic and Interventional Imaging
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