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https://www.readbyqxmd.com/read/28446073/recurrent-hemarthrosis-due-to-iatrogenic-avf-treated-with-onyx-embolization
#1
Issam Koleilat, John Phair
A 78-year-old gentleman presented with recurrent symptomatic hemarthrosis after total knee arthroplasty. His workup revealed an iatrogenic arteriovenous fistula (iAVF). The iAVF was embolized with the Onyx Liquid Embolization System with resolution of his symptoms up to 10 months of follow-up. This is the first description to our knowledge of an iatrogenic hemarthrosis after total knee arthroplasty successfully treated with Onyx solution embolization.
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28436714/a-hemorrhagic-complication-after-onyx-embolization-of-a-tentorial-dural-arteriovenous-fistula-a-caution-about-subdural-extension-with-pial-arterial-supply
#2
Kenichi Sato, Yasushi Matsumoto, Hidenori Endo, Teiji Tominaga
We report a case of tentorial dural arteriovenous fistula (DAVF) with a severe intracranial hemorrhage occurring after Onyx embolization. A 40-year-old man presented with an asymptomatic tentorial DAVF on angiography. Transarterial embolization with Onyx was performed via the middle meningeal artery, and the cast filled the fistula itself and its proximal draining vein. Postoperative angiography confirmed complete occlusion of the DAVF. A computed tomography scan performed immediately after the procedure demonstrated an acute subdural hematoma with the temporal hemorrhage...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28427848/early-outcomes-and-periprocedural-complications-of-transarterial-embolization-of-brain-arteriovenous-malformations-with-onyx-%C3%A2
#3
Wojciech Poncyljusz, Marcin Sawicki, Katarzyna Lubkowska, Monika Rać
BACKGROUND: Brain arteriovenous malformation (BAVM) is a rare pathology diagnosed mostly in young adults. However, due to its hemorrhagic complications, it constitutes an important clinical problem. Treatment modalities available include endovascular, surgery and radiosurgery. The aim of the study was to assess the efficacy and safety of endovascular treatment of BAVM with Onyx(®) by reporting one-center experience. MATERIAL AND METHODS: Between 2006 and 2013, 54 patients with BAVM were embolized with Onyx...
April 5, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28413072/progressive-regression-of-intracranial-arteriovenous-malformations-after-onyx-embolization
#4
Damian Kocur, Nikodem Przybyłko, Mariusz Hofman, Tomasz Jamróz, Hanna Doleżych, Jan Baron, Stanisław Kwiek
Progressive regression of cerebral arteriovenous malformations (AVMs) is a rare phenomenon that may occur spontaneously or after previous surgical or endovascular incomplete obliteration. We present two cases of AVMs occluded partially with Onyx followed by the unexpected cure of the lesions with the angiographic evidences as well as multiannual follow-up.
April 4, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28411709/chronic-refractory-venous-ulcer-exacerbated-by-a-congenital-pelvic-arteriovenous-malformation-successfully-treated-by-transarterial-onyx-embolization
#5
Naiem Nassiri, Dustin T Crystal, Catherine Hoyt, Randy Shafritz
Congenital arteriovenous malformations (AVMs) are an important but often neglected cause of lower extremity venous hypertension. A case of a chronic refractory venous stasis ulcer of the lower extremity exacerbated by a pelvic AVM is presented. Healing of the ulcer was achieved at 2 months without recurrence at 1 year after superselective ethylene vinyl alcohol copolymer (Onyx 34; ev3, Covidien, Plymouth, Minn) embolization of the AVM nidus. Chronic venous arterialization should be considered in cases of refractory, nonhealing venous ulcers...
May 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28378096/spinal-extradural-arteriovenous-fistula-with-intradural-drainage-three-surgical-cases-with-long-term-follow-up
#6
Enrique J Vázquez, Joaquín Gefaell, Leticia Fernandez, Eva López, Eduardo Areitio, Jose A Elexpuru
Spinal extradural arteriovenous fistulas (SEDAVF) with intradural drainage are uncommon vascular lesions that cause venous congestive myelopathy. We present three SEDAVF with intradural drainage treated with surgical disconnection of the intradural drainage via a single level laminectomy, followed by transarterial embolization (TAE) with Onyx if spontaneous thrombosis of the extradural fistula did not occur spontaneously. All patients improved their neurological condition and no congestive myelopathy recurrence was noted after mean follow-up of 84 months...
April 4, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28316864/in-vitro-quantification-of-the-radiopacity-of-onyx-during-embolization
#7
Yuan Yuan Jiang, Ye-Eun Jo, Jung Min Woo, Ok Kyun Lim, Changmo Hwang, Jun Young Maeng, Jieun Kim, Namkug Kim, Deok Hee Lee
PURPOSE: Onyx has been successfully applied in the treatment of various neurovascular lesions. However, some experience is required to get accustomed to its unpredictable fluoroscopic visibility during injection. This in vitro study aimed to evaluate the characteristics of radiopacity change in a simulated embolization procedure. MATERIALS AND METHODS: Using a bench-top Onyx injection experiment simulating a typical brain arteriovenous malformation embolization, nine cycles of casting modes (continuous injection) and plugging modes (injection with intermittent pauses) were performed...
March 2017: Neurointervention
https://www.readbyqxmd.com/read/28298038/surgical-removal-of-embolic-material-after-its-unexpected-migration-through-extracranial-intracranial-anastomosis-in-the-treatment-of-barrow-type-d-carotid-cavernous-fistula-case-report
#8
Jae-Sang Oh, Dong-Sung Kim, Jai-Joon Shim, Seok-Mann Yoon
Endovascular occlusion via the transvenous route is the favored treatment for indirect carotid-cavernous fistulas (CCFs). However, transarterial embolization can be used as an alternative method in patients with an inaccessible venous route. The authors present the case of a 49-year-old woman with a 2-month history of chemosis and proptosis in her right eye. Angiography demonstrated a Barrow Type D CCF. Transarterial Onyx embolization through the accessory meningeal artery was performed after an unsuccessful transvenous approach...
March 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28288323/anti-angiogenic-and-anti-multiple-myeloma-effects-of-oprozomib-opz-alone-and-in-combination-with-pomalidomide-pom-and-or-dexamethasone-dex
#9
REVIEW
Eric Sanchez, Mingjie Li, Cathy S Wang, George Tang, Abigail Gillespie, Haiming Chen, James R Berenson
Oprozomib (OPZ or ONYX 0912) is an irreversible, orally administered proteasome inhibitor (PI) and an analog of carfilzomib. We set out to determine the anti-angiogenic effect of OPZ using the choriollantoic membrane/feather bud (CAM/FB) model and its anti-MM effects using MM xenograft models (LAGκ-1A, LAGλ-1). OPZ significantly reduced blood vessel formation, endothelial gene and protein expression using the CAM/FB assay. In vivo, we determined the anti-MM effects of OPZ, dexamethasone (Dex) and pomalidomide (Pom) and showed that the combinations of two drugs (OPZ+Dex or OPZ+Pom) showed marked anti-MM effects when compared to monotherapy...
March 6, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28263419/transoral-ultrasonic-surgery-of-pharyngolaryngeal-giant-hemangioma-after-ethylene-vinyl-alcohol-copolymer-onyx-embolization
#10
Meritxell Valls-Mateus, Luis San Román, Juan Macho, Alfons Nadal, Manuel Bernal-Sprekelsen, Isabel Vilaseca
BACKGROUND: Cervico-mediastinal hemangiomas in adulthood are rare and slow-growing vascular tumors. The optimal treatment for giant hemangiomas is controversial. In asymptomatic cases, clinical observation is generally recommended. METHODS: We report the transoral resection of a pharyngolaryngeal hemangioma (diameters of 44 × 56 × 39 mm) with tracheal involvement and mediastinal extension. Clinically, the patient had throat foreign body sensation, severe dyspnea and stridor...
March 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/28204981/phase-1b-trial-of-proteasome-inhibitor-carfilzomib-with-irinotecan-in-lung-cancer-and-other-irinotecan-sensitive-malignancies-that-have-progressed-on-prior-therapy-onyx-ist-reference-number-car-ist-553
#11
Susanne M Arnold, Kari Chansky, Markos Leggas, Michael A Thompson, John L Villano, John Hamm, Rachel E Sanborn, Glen J Weiss, Gurkamal Chatta, Maria Q Baggstrom
Introduction Proteasome inhibition is an established therapy for many malignancies. Carfilzomib, a novel proteasome inhibitor, was combined with irinotecan to provide a synergistic approach in relapsed, irinotecan-sensitive cancers. Materials and Methods Patients with relapsed irinotecan-sensitive cancers received carfilzomib (Day 1, 2, 8, 9, 15, and 16) at three dose levels (20/27 mg/m2, 20/36 mg/m2 and 20/45 mg/m2/day) in combination with irinotecan (Days 1, 8 and 15) at 125 mg/m2/day. Key eligibility criteria included measurable disease, a Zubrod PS of 0 or 1, and acceptable organ function...
February 16, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28196614/safety-and-efficacy-of-embolization-using-onyx-%C3%A2-of-persistent-type-ii-endoleaks-after-abdominal-endovascular-aneurysm-repair
#12
C Marcelin, Y Le Bras, F Petitpierre, D Midy, E Ducasse, N Grenier, F Cornelis
PURPOSE: To retrospectively evaluate the safety and efficacy of embolization of persistent type II endoleaks occurring after abdominal endovascular aneurysm repair (EVAR) using ethylene vinyl alcohol copolymer (Onyx(®)). MATERIAL AND METHODS: Between 2008 and 2016, 28 consecutives patients (25 men, 3 women) with a mean age of 75.3years±9 (SD) (range: 59-90years) were treated for 29 persistent type II endoleaks with increasing aneurysm size>5mm occurring after EVAR...
February 10, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28195862/a-case-report-of-onyx-pulmonary-arterial-embolism-contributing-to-hypoxemia-during-awake-craniotomy-for-arteriovenous-malformation-resection
#13
Brian T Tolly, Jenna L Kosky, Antoun Koht, Laura B Hemmer
A healthy 26-year-old man with cerebral arteriovenous malformation underwent staged endovascular embolization with Onyx followed by awake craniotomy for resection. The perioperative course was complicated by tachycardia and severe intraoperative hypoxemia requiring significant oxygen supplementation. Postoperative chest computed tomography (CT) revealed hyperattenuating Onyx embolization material within the pulmonary vasculature, and an electrocardiogram indicated possible right heart strain, supporting clinically significant embolism...
February 15, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28194506/treatment-of-type-ii-endoleaks-with-a-novel-agent-precipitating-hydrophobic-injectable-liquid-phil
#14
Amir Helmy, Nadeem Shaida
OBJECTIVE: Endovascular aortic aneurysm repair has become the principle technique used to treat abdominal aortic aneurysms. However, its long-term success is limited by complications, including type II endoleaks from lumbar arteries and the inferior mesenteric artery. Treatment of these endoleaks can be difficult. The most commonly performed procedure is embolisation via mesenteric or iliolumbar vessels. Embolic agents currently used include coils, glue and Onyx, all of which have their limitations...
February 13, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28184352/spontaneous-aggressive-conversion-of-venous-drainage-pattern-in-dural-arteriovenous-fistula-treated-with-onyx-embolization
#15
Yeongu Chung, Seok Keun Choi, Sung Ho Lee, Eui Jong Kim
We report a case of dural arteriovenous fistula (DAVF) that showed spontaneous conversion of venous drainage pattern from Borden type II to type III within a four month period of follow-up. Upon admission, the patient presented with aggravated neurologic status and newly developed seizure. After admission, endovascular embolization was performed through the middle meningeal artery with Onyx®. Complete obliteration of dural arteriovenous shunt was confirmed by angiography, and the patient's clinical symptoms improved...
December 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/28161148/cognard-type-v-dural-arteriovenous-fistula-involving-the-occipital-sinus
#16
Jun Tanaka, Atsushi Fujita, Masahiro Maeyama, Masaaki Kohta, Kohkichi Hosoda, Eiji Kohmura
The Cognard type V dural arteriovenous fistula (dAVF), which has a drainage route into the spinal vein, is a rare subtype of cranial dAVF. Because of typical features such as progressive myelopathy and brainstem dysfunctions, aggressive treatments should be considered. To eliminate venous congestion of the spinal cord, various approaches including surgical interruption of the spinal draining vein or transarterial embolization with cyanoacrylate have been reported. The introduction of nonadhesive Onyx has changed the treatment of dAVF, although little is known about the clinical usefulness of this type of fistula...
February 1, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28158308/inefficiencies-and-patient-burdens-in-the-development-of-the-targeted-cancer-drug-sorafenib-a-systematic-review
#17
James Mattina, Benjamin Carlisle, Yasmina Hachem, Dean Fergusson, Jonathan Kimmelman
Failure in cancer drug development exacts heavy burdens on patients and research systems. To investigate inefficiencies and burdens in targeted drug development in cancer, we conducted a systematic review of all prelicensure trials for the anticancer drug, sorafenib (Bayer/Onyx Pharmaceuticals). We searched Embase and MEDLINE databases on October 14, 2014, for prelicensure clinical trials testing sorafenib against cancers. We measured risk by serious adverse event rates, benefit by objective response rates and survival, and trial success by prespecified primary endpoint attainment with acceptable toxicity...
February 2017: PLoS Biology
https://www.readbyqxmd.com/read/28145934/efficacy-and-safety-of-willis-covered-stent-for-treatment-of-internal-carotid-artery-aneurysms
#18
Chunhai Tang, Songtao Qi
OBJECTIVE: The purpose of this study was to evaluate the clinical and short-term outcome of patients who underwent covered stent treatment for internal carotid artery aneurysms. METHODS: Twelve cases patients with internal carotid artery aneurysms were treated with Willis covered stents during the period from December 2010 to January 2016. The guiding catheter was placed as high as possible to facilitate the delivery of the covered stent system. RESULTS: Covered stent placement was successful in 11 of 12 case patients (91...
January 31, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28126173/early-and-midterm-outcomes-after-transcatheter-embolization-of-type-i-endoleaks-in-25-patients
#19
Seyed Ameli-Renani, Vyzantios Pavlidis, Robert A Morgan
OBJECTIVE: This study reports the technical success and follow-up results of transcatheter embolization of type I endoleak (ELI) in 25 patients after endovascular aortic repair (EVAR). METHODS: Twenty-five patients with ELI (20 men, five women; mean age 80 years; range, 64-96 years) underwent embolization of abdominal ELI (23 proximal, 2 distal endoleaks) after EVAR. All patients were unsuitable for standard endovascular methods for treatment of ELI. The average aneurysm sac size before embolization was 8...
February 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28106525/open-and-endovascular-treatment-of-spinal-dural-arteriovenous-fistulas-a-10-year-experience
#20
Matthew J Koch, Christopher J Stapleton, Pankaj K Agarwalla, Collin Torok, John H Shin, Jean-Valery Coumans, Lawrence F Borges, Christopher S Ogilvy, James D Rabinov, Aman B Patel
OBJECTIVE Vascular malformations of the spine represent rare clinical entities with profound neurological implications. Previously reported studies on management strategies for spinal dural arteriovenous fistulas (sDAVFs) appeared before the advent of modern liquid embolic agents. Authors of the present study review their institutional experience with endovascularly and surgically treated sDAVFs. METHODS The authors performed a retrospective, observational, single-center case series on sDAVFs treated with endovascular embolization, microsurgical occlusion, or both between 2004 and 2013...
April 2017: Journal of Neurosurgery. Spine
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