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https://www.readbyqxmd.com/read/29781371/quantification-of-tantalum-sedimentation-rates-in-liquid-embolic-agents
#1
J R Mason, C Dodge, G Benndorf
Background Endovascular treatment (EVT) of brain arteriovenous malformations has evolved from cyanoacrylate derivatives such as N-butyl cyanoacrylate, an adhesive glue, to ethylene vinyl copolymer-based liquid embolics such as Onyx® and SQUID® dissolved in dimethyl sulfoxide. Although these agents offer several advantages, their rapidly decreasing radiopacity, as a result of the sedimentation of tantalum powder, compromises visual control during EVT. This study aims to quantify and compare tantalum sedimentation rates of several liquid embolic agents, and determine their effects on radiopacity...
January 1, 2018: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29780232/cerebral-arteriovenous-malformations-in-the-era-of-embolization-for-angiographic-cure-a-single-center-experience-in-egypt
#2
Mohamed K Elewa
Background: Embolization for cerebral arteriovenous malformations (AVMs) has evolved in the last decade with evolution in both equipment and material. Embolization targets have expanded to include angiographic cure. Methods: To discuss the technical and management outcomes of our first cerebral AVM case series treated with embolization. The clinical, angiographic, treatment, and outcome variables of consecutive cerebral arteriovenous malformation cases, treated with curative embolization, between January 2011 and June 2017 in one regional center, were retrospectively analyzed...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
https://www.readbyqxmd.com/read/29774181/embolization-with-ethylene-vinyl-alcohol-copolymer-onyx-%C3%A2-for-peripheral-hemostatic-and-non-hemostatic-applications-a-feasibility-and-safety-study
#3
Romaric Né, Olivier Chevallier, Nicolas Falvo, Olivier Facy, Pierre-Emmanuel Berthod, Christophe Galland, Sophie Gehin, Marco Midulla, Romaric Loffroy
Background: Onyx® is a liquid embolic agent, which is approved for the treatment of cerebral vascular lesions but still rarely used in peripheral interventional radiology. The goal of this study is to report the feasibility and safety of embolization with Onyx® for peripheral hemostatic and non-hemostatic endovascular procedures. Methods: Retrospective study of all consecutive patients who underwent visceral or peripheral embolization with Onyx® for hemostatic or non-hemostatic purpose in our department between May 2014 and November 2016...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29765484/successful-embolization-of-a-enterocutaneous-fistula-tract-with-onyx-34-following-low-anterior-resection-for-rectal-cancer
#4
Hamza Rahimi, Anthony C Venbrux, Vincent Obias
Enterocutaneous fistulas (ECFs) can be one of the complications found after surgical intervention for rectal cancer. Interventional modalities consisting of surgical, endoscopic, and radiological methods are often implemented to treat postoperative symptomatic complications. We present the case of 61-year-old Caucasian man who presented to us with a recent diagnosis of rectal cancer that had invaded the levators as well as anteriorly into the prostate, and who underwent low anterior resection with a diverting loop ileostomy...
June 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29765390/preclinical-evaluation-of-the-nevatm-stent-retriever-safety-and-efficacy-in-the-swine-thrombectomy-model
#5
Arthur J Ulm, Tigran Khachatryan, Arthur Grigorian, Raul G Nogueira
Background: A novel stent retriever device with an enhanced radial force profile, enlarged offset openings, and a closed distal end has been developed. Objective: Evaluate the safety and effectiveness of the NeVaTM thrombectomy device in animal model of thrombo-occlusive disease. Materials and Methods: Seven swine were used in safety and efficacy studies. Thrombo-occlusive disease was modeled using 4 emboli morphologies; 2 distinct models of autologous whole blood thrombi, plasma-enriched thrombi, and Onyx® emboli...
April 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29751190/preoperative-embolization-of-skull-base-meningiomas-outcomes-in-the-onyx-era
#6
Colin J Przybylowski, Jacob F Baranoski, Alfred P See, Bruno C Flores, Rami O Almefty, Dale Ding, Kristina M Chapple, Nader Sanai, Andrew F Ducruet, Felipe C Albuquerque
OBJECTIVE: Preoperative embolization may facilitate skull base meningioma resection, but its safety and efficacy in the Onyx era have not been investigated. In this retrospective cohort study, we evaluated the outcomes of preoperative embolization of skull base meningiomas using Onyx as the primary embolysate. METHODS: We queried an endovascular database for patients with skull base meningiomas who underwent preoperative embolization at our institution in 2007-2017...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29751188/reversible-cerebral-vasoconstriction-syndrome-as-an-unusual-complication-of-a-dural-arteriovenous-fistula-treated-with-onyx-embolization
#7
Douglas Gonsales, Fabiano das Gracas, Roberta Santos, Pedro Aguilar-Salinas, Ricardo A Hanel
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) is a rare entity with an unknown pathophysiology. RCVS has been reported to occur more frequently in women aged 20 to 50 years. Several mechanisms have been postulated involving transient deregulation of cerebral arterial tone, small vessel endothelial dysfunction, biochemical factors, hormonal deregulation, oxidative stress, and genetic predisposition. All these mechanisms and triggers are related with sympathetic over-activation which eventually produce vasoconstriction...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29751183/onyx-embolization-before-the-surgical-treatment-of-grade-iii-spetzler-martin-brain-arteriovenous-malformations-single-center-experience-and-technical-nuances
#8
S Luzzi, M Del Maestro, D Bongetta, C Zoia, A V Giordano, D Trovarelli, Dehcordi S Raysi, R J Galzio
BACKGROUND: grade-III Spetzler-Martin (SM) brain arteriovenous malformations (AVMs) are a specific set of AVMs with a high variability in terms of site, size, angioarchitecture, flow dynamics and involvement of eloquent areas. Surgery preceded by pre-operative embolization has been reported as a useful treatment option for these lesions. The aim of this study is to report outcomes and personal experience of combined pre-operative Onyx embolization and surgical resection on a consecutive series of grade-III brain AVMs...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29749011/rapid-lc-ms-ms-method-for-quantification-of-vinorelbine-and-4-o-deacetylvinorelbine-in-human-whole-blood-suitable-to-monitoring-oral-metronomic-anticancer-therapy
#9
Giuseppe Corona, Milena Gusella, Anna Gaspardo, Gianmaria Miolo, Laura Bertolaso, Elisa Pezzolo, Felice Pasini, Agostino Steffan, Donatella Caruso
A rapid and sensitive LC-MS/MS method for therapeutic drug monitoring oral vinorelbine (VRL) metronomic anticancer chemotherapy has been developed and validated. Analysis of VRL and its main active metabolite 4-O-deacetylvinorelbine (M1) was performed in whole blood matrix. Both analytes were extracted by protein precipitation and separated on an Onyx monolith C18, 50 x 2 mm column then quantified by positive electrospray ionization and multiple reaction monitoring mode. The LLOQ was 0.05 ng/mL for both VRL and M1...
May 10, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29745969/comparison-of-short-term-clinical-outcomes-between-resolute-onyx-zotarolimus-eluting-stents-and-everolimus-eluting-stent-in-patients-with-acute-myocardial-infarction-results-from-the-korea-acute-myocardial-infarction-registry-kamir
#10
Yongcheol Kim, Sung Sik Oh, Myung Ho Jeong, Youngkeun Ahn, Ju Han Kim, Young Joon Hong, Doo Sun Sim, Min Chul Kim, Hyo-Soo Kim, Kyeong Ho Yun, Seok Kyu Oh, Chong Jin Kim, Myeong Chan Cho
BACKGROUND: There are few studies which compare the efficacy and safety of the Resolute Onyx zotarolimus-eluting stent (O-ZES) and everolimus-eluting stent (EES) in patients with acute myocardial infarction (AMI). Therefore, the present study aimed to compare clinical outcomes of O-ZES and EES in patients with AMI undergoing successful percutaneous coronary intervention (PCI). METHODS: From January 2016 to December 2016, the Korea Acute Myocardial Infarction Registry (KAMIR) enrolled 3,364 consecutive patients...
May 10, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29730099/may-the-inferior-petrosal-sinus-recanalization-during-endovascular-treatment-for-carotid-cavernous-fistulas-increase-the-risk-of-sixth-nerve-palsy
#11
Thomas Robert, Daniele Valsecchi, Philippe Sylvestre, Raphaël Blanc, Gabriele Ciccio, Stanislas Smajda, Hocine Redjem, Michel Piotin
INTRODUCTION: Sixth nerve palsy is a common complication of endovascular treatment for carotid-cavernous fistulas (CCF). Two hypotheses are evoked: the spontaneous venous congestion into the cavernous sinus (CS), and the direct compression of the nerve by the embolic agent into the CS. Nevertheless, the evidence is still uncertain. Knowing the vicinity of the sixth nerve with the inferior petrosal sinus (IPS) in the Dorello's canal, we hypothesized that the recanalization of the IPS increased the risk of nerve damage...
May 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29729465/the-procedure-related-complications-of-transarterial-onyx-embolization-of-dural-arteriovenous-fistula-using-transvenous-balloon-protection
#12
Feng Guo, Yupeng Zhang, Shikai Liang, Fei Liang, Peng Yan, Chuhan Jiang
OBJECTIVE: Transarterial embolizatioin with transvenous balloon protection has been described as a promising technique for intracranial dural arteriovenous fistula. The aim of our study was to report our preliminary experiences of this technique with regard to its safety and efficacy, emphasize the procedure-related complications. METHODS: Fourteen consecutive patients with DAVF were treated with transvenous balloon assisted technique between March 2014 and November 2017...
May 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29719340/embolization-with-onyx-%C3%A2-of-an-arterial-pseudoaneurysm-with-an-arteriovenous-fistula-complicating-a-percutaneous-nephrolithotomy-a-case-report-and-review-of-literature
#13
Ana Isabel Simões Ferreira, Filipe Veloso Gomes, Tiago Bilhim, Élia Coimbra
Percutaneous nephrolithotomy (PCNL) has proven very effective in the management of renal stones. However, complications are not so rare, and bleeding is one of the most worrisome; it has a reported incidence of 1%-3% and may happen during track dilatation. In addition, arterial pseudoaneurysms and/or arteriovenous fistulas (AVF) may occur. We report the case of a patient with an intrarenal pseudoaneurysm associated with an AVF, after PCNL. Superselective endovascular embolization with Onyx® was successfully performed, achieving exclusion of the pseudoaneurysm and AVF with preservation of the remaining vascularization of the kidney...
April 2018: Urology Annals
https://www.readbyqxmd.com/read/29694283/letter-incorporating-real-world-evidence-and-patient-value-criteria-into-value-based-frameworks-for-relapsed-refractory-multiple-myeloma
#14
Robert Z Orlowski
Orlowski has received research funding from Amgen, BioTheryX, Bristol-Myers Squibb, Celgene Corporation, and Takeda Pharmaceuticals; honoraria from Amgen, Bristol-Myers Squibb, Celgene Corporation, Janssen, Millennium Pharmaceuticals, and Onyx Pharmaceuticals; and is a member of advisory boards for Amgen, Bristol-Myers Squibb, Celgene Corporation, Incyte, Kite, Legend Biotech, Sanofi-Aventis, and Takeda Pharmaceuticals.
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29660051/resection-of-right-frontal-arteriovenous-malformation-3-dimensional-operative-video
#15
William T Couldwell
The video demonstrates resection of a Grade II Spetzler-Martin unruptured, medium-sized arteriovenous malformation (AVM). A young woman presented with headaches and seizures. The right frontal lesion measured 4.5 cm in largest dimension and had superficial venous drainage. Partial Onyx embolization, primarily of the anterior cerebral feeding arteries, was performed. Bone removal for exposure allowed identification of indentation from the large superficial draining vein. The video demonstrates careful microsurgical dissection on the AVM/brain interface, with selective interruption of feeding arteries circumferentially...
April 11, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29627790/embolization-of-a-cavernous-carotid-fistula-through-the-vein-of-labb%C3%A3-a-new-alternative-transvenous-access-route
#16
Angelos Aristeidis Konstas, Alice Song, Julia Song, Aristomenis Thanos, Ian B Ross
Endovascular treatment of carotid cavernous fistulas (CCFs) via a transvenous approach is standard, but in rare cases this approach is challenging due to absence or thrombosis of the commonly used venous routes. A 61-year-old woman presented with a symptomatic CCF with all but one of the venous access routes to the CCF thrombosed, leaving an engorged superficial middle cerebral vein (SMCV) as the only venous outflow from the cavernous sinus. Access to the CCF was made possible after careful navigation of the sigmoid sinus, the vein of Labbé and the SMCV, bypassing the need for surgical access to the SMCV or for a direct transorbital puncture...
April 7, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29572266/increase-in-fluoroscopic-radiation-dose-in-successive-sessions-of-multistage-onyx-embolization-of-brain-arteriovenous-malformations-compared-with-the-first-session
#17
Jae Jon Sheen, Yuan Yuan Jiang, Young Eun Kim, Jun Young Maeng, Tae-Il Kim, Deok Hee Lee
BACKGROUND AND PURPOSE: Onyx embolization is a treatment for brain arteriovenous malformations (AVMs). However, multistage embolization usually involves the presence of radiodense Onyx cast from the previous sessions, which may influence the fluoroscopic radiation dose. We compared the fluoroscopic dose between the initial and final embolization sessions. MATERIALS AND METHOD: From January 2014 to September 2016, 18 patients underwent multistage Onyx embolization (more than twice) for brain AVMs...
March 23, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29570006/use-of-the-apollo-detachable-tip-microcatheter-for-endovascular-embolization-of-arteriovenous-malformations-and-arteriovenous-fistulas
#18
Bruno C Flores, Alfred P See, Gregory M Weiner, Brian T Jankowitz, Andrew F Ducruet, Felipe C Albuquerque
OBJECTIVE Liquid embolic agents have revolutionized endovascular management of arteriovenous malformations (AVMs) and arteriovenous fistulas (AVFs). Nonetheless, since 2005, the US FDA has received more than 100 reports of microcatheter breakage or entrapment related to Onyx embolization, including 9 deaths. In 2014, the Apollo detachable-tip microcatheter became the first of its kind available in the US. Since then, few reports on its safety have been published. METHODS The authors conducted a retrospective review of endovascular cases by searching the patient databases at 2 tertiary cerebrovascular centers (Barrow Neurological Institute and University of Pittsburgh Medical Center)...
March 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29567872/-tentorial-dural-arteriovenous-fistula-presenting-with-ocular-symptoms-a-case-report
#19
Naotsugu Toki, Osamu Masuo, Hiroki Nishibayashi, Rie Yako, Takumi Kawaguchi, Daisuke Izawa, Naoyuki Nakao
Tentorial dural arteriovenous fistula(dAVF)is classified as Cognard 4 with a high risk of aggressive feature, such as intracranial hemorrhage, venous infarction, and intracranial hypertension. We report a rare case presenting with ocular symptoms caused by tentorial dAVF. A 59-year-old man presented with progressive chemosis and exophthalmos of his left eye. Angiography showed a tentorial dAVF that was primarily fed by the middle meningeal artery and the meningohypophyseal artery. The AVF drained into the superior ophthalmic vein and the cerebellar cortical vein via an enlarged petrosal vein...
March 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29518926/facial-nerve-paralysis-after-onyx-embolization-of-a-jugular-paraganglioma-a-case-report-with-a-long-term-follow-up
#20
Haitham Odat, Khaled Alawneh, Mohannad Al-Qudah
Jugular paragangliomas are slow growing highly vascular tumors arising from jugular paraganglia. The gold standard of treatment is complete surgical resection. Pre-operative embolization of these highly vascular tumors is essential to reduce intra-operative bleeding, allow safe dissection, and decrease operative time and post-operative complications. Onyx (ethylene-vinyl alcohol copolymer) has been widely used as permanent occluding material for vascular tumors of skull base because of its unique physical properties...
March 7, 2018: Journal of Clinical Medicine
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