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https://www.readbyqxmd.com/read/25160617/escherichia-coli-d-malate-dehydrogenase-a-generalist-enzyme-active-in-the-leucine-biosynthesis-pathway
#1
Anastassia A Vorobieva, Mohammad Shahneawz Khan, Patrice Soumillion
The enzymes of the β-decarboxylating dehydrogenase superfamily catalyze the oxidative decarboxylation of D-malate-based substrates with various specificities. Here, we show that, in addition to its natural function affording bacterial growth on D-malate as a carbon source, the D-malate dehydrogenase of Escherichia coli (EcDmlA) naturally expressed from its chromosomal gene is capable of complementing leucine auxotrophy in a leuB(-) strain lacking the paralogous isopropylmalate dehydrogenase enzyme. To our knowledge, this is the first example of an enzyme that contributes with a physiologically relevant level of activity to two distinct pathways of the core metabolism while expressed from its chromosomal locus...
October 17, 2014: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/21036588/lipoic-acid-stimulates-camp-production-via-g-protein-coupled-receptor-dependent-and-independent-mechanisms
#2
Sonemany Salinthone, Robynn V Schillace, Catherine Tsang, John W Regan, Dennis N Bourdette, Daniel W Carr
Lipoic acid (LA) is a naturally occurring fatty acid that exhibits anti-oxidant and anti-inflammatory properties and is being pursued as a therapeutic for many diseases including multiple sclerosis, diabetic polyneuropathy and Alzheimer's disease. We previously reported on the novel finding that racemic LA (50:50 mixture of R-LA and S-LA) stimulates cAMP production, activates prostanoid EP2 and EP4 receptors and adenylyl cyclases (AC), and suppresses activation and cytotoxicity in NK cells. In this study, we present evidence that furthers our understanding of the mechanisms of action of LA...
July 2011: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/20233924/regulation-of-aerobic-and-anaerobic-d-malate-metabolism-of-escherichia-coli-by-the-lysr-type-regulator-dmlr-yeat
#3
Hanna Lukas, Julia Reimann, Ok Bin Kim, Jan Grimpo, Gottfried Unden
Escherichia coli K-12 is able to grow under aerobic conditions on D-malate using DctA for D-malate uptake and the D-malate dehydrogenase DmlA (formerly YeaU) for converting D-malate to pyruvate. Induction of dmlA encoding DmlA required an intact dmlR (formerly yeaT) gene, which encodes DmlR, a LysR-type transcriptional regulator. Induction of dmlA by DmlR required the presence of D-malate or L- or meso-tartrate, but only D-malate supported aerobic growth. The regulator of general C(4)-dicarboxylate metabolism (DcuS-DcuR two-component system) had some effect on dmlA expression...
May 2010: Journal of Bacteriology
https://www.readbyqxmd.com/read/16085827/two-rhizobial-strains-mesorhizobium-loti-maff303099-and-bradyrhizobium-japonicum-usda110-encode-haloalkane-dehalogenases-with-novel-structures-and-substrate-specificities
#4
Yukari Sato, Marta Monincová, Radka Chaloupková, Zbynek Prokop, Yoshiyuki Ohtsubo, Kiwamu Minamisawa, Masataka Tsuda, Jirí Damborsky, Yuji Nagata
Haloalkane dehalogenases are key enzymes for the degradation of halogenated aliphatic pollutants. Two rhizobial strains, Mesorhizobium loti MAFF303099 and Bradyrhizobium japonicum USDA110, have open reading frames (ORFs), mlr5434 and blr1087, respectively, that encode putative haloalkane dehalogenase homologues. The crude extracts of Escherichia coli strains expressing mlr5434 and blr1087 showed the ability to dehalogenate 18 halogenated compounds, indicating that these ORFs indeed encode haloalkane dehalogenases...
August 2005: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/15499277/-role-of-vitrectomy-in-patients-with-a-decrease-in-visual-acuity-secondary-to-asteroid-hyalosis
#5
M Boissonnot, H Manic, S Balayre, P Dighiero
PURPOSE: Asteroid hyalosis is a vitreous degeneration with calcium and phosphorus--lipid complexes in elderly patients with vascular risk factors or general disease such as diabetes mellitus. Synchysis scintillans is a complication of pathological eyes. Generally there are no symptoms. This study aims to evaluate the role of vitrectomy in patients with a decrease in visual acuity. CASE REPORTS: Pars plana vitrectomy was performed in three patients with visual acuity less than 1/10...
September 2004: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/14586233/-the-role-of-surgery-in-the-treatment-of-age-related-macular-degeneration
#6
P Gastaud
The place of surgery in DMLA amounts to the surgical treatment of choroidal neovascular membranes and submacular hemorrhage. After a brief historical review, the different techniques currently used are described, but indications have become rarer since the development of dynamic phototherapy. However, despite a high complication rate, these surgical methods should not disappear from our therapeutic arsenal because they have proved their ability to restore good visual acuity.
October 2003: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/9893587/case-control-study-of-the-risk-factors-for-age-related-macular-degeneration-france-dmla-study-group
#7
G Chaine, A Hullo, J Sahel, G Soubrane, M A Espinasse-Berrod, D Schutz, C Bourguignon, C Harpey, Y Brault, M Coste, D Moccatti, H Bourgeois
AIM: A case-control study was initiated to determine the risk factors for the development of age related macular degeneration (AMD). METHODS: Study participants, who were all white, aged 50-85 years, and were recruited from private ophthalmology practices. Each practitioner enrolled patients with bilateral AMD, who were then matched with controls for sex and age. Environmental factors and systemic and ocular histories were screened. All patients had bilateral red-free fundus photographs and fluorescein angiography...
September 1998: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/2084271/experimental-and-theoretical-research-in-archery
#8
R Pekalski
The aim of this study was to introduce certain methods and research techniques and to present the results of experiments on parameters of archery equipment to optimize the interaction of the archer-bow-arrow system's elements. In order to achieve the research requirements, the following were devised: 1. A mathematical model of an arrow's movement during its interaction with a bow. 2. A mechanical model of an archer-bow-arrow system, which constitutes a device for mechanical loosing of an arrow from the bow strings (DMLA)...
1990: Journal of Sports Sciences
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