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Megan M Chang, Danielle Allery Nail, Toni Kazic, Susan J Simmons, Ann E Stapleton
Crop improvement must accelerate to feed an increasing human population in the face of environmental changes. Including anticipated climatic changes with genetic architecture in breeding programs could better optimize improvement strategies. Combinations of drought and nitrogen limitation already occur world-wide. We therefore analyzed the genetic architecture underlying the response of Zea mays to combinations of water and nitrogen stresses. Recombinant inbreds were subjected to nine combinations of the two stresses using an optimized response surface design, and their growth was measured...
May 4, 2018: G3: Genes—Genomes—Genetics
M Giuliani, E Bartolini, B Galli, L Santini, P Lo Surdo, F Buricchi, M Bruttini, B Benucci, N Pacchiani, L Alleri, D Donnarumma, W Pansegrau, I Peschiera, I Ferlenghi, R Cozzi, N Norais, M M Giuliani, D Maione, M Pizza, R Rappuoli, O Finco, V Masignani
4CMenB is the first broad coverage vaccine for the prevention of invasive meningococcal disease caused by serogroup B strains. To gain a comprehensive picture of the antibody response induced upon 4CMenB vaccination and to obtain relevant translational information directly from human studies, we have isolated a panel of human monoclonal antibodies from adult vaccinees. Based on the Ig-gene sequence of the variable region, 37 antigen-specific monoclonal antibodies were identified and produced as recombinant Fab fragments, and a subset also produced as full length recombinant IgG1 and functionally characterized...
February 27, 2018: Scientific Reports
Fulvio Braido, Ilaria Baiardini, Pietro Alleri, Elena Bacci, Carlo Barbetta, Michela Bellocchia, Alida Benfante, Francesco Blasi, Caterina Bucca, Maria Teresa Busceti, Stefano Centanni, Maria Cristina Colanardi, Marco Contoli, Angelo Corsico, Maria D'Amato, Fabiano Di Marco, Dottorini Marco, Marta Ferrari, Giovanni Florio, Alessandro Giuseppe Fois, Maria Pia Foschino Barbaro, Garuti Silvia, Giuseppe Girbino, Amelia Grosso, Manuela Latorre, Sara Maniscalco, Francesco Mazza, Carlo Mereu, Giorgia Molinengo, Josuel Ora, Pierluigi Paggiaro, Vincenzo Patella, Girolamo Pelaia, Pietro Pirina, Alfio Proietto, Paola Rogliani, Pierachille Santus, Nicola Scichilone, Francesca Simioli, Paolo Solidoro, Silvia Terraneo, Umberto Zuccon, Giorgio Walter Canonica
BACKGROUND: Asthma considerably impairs patients' quality of life and increases healthcare costs. Severity, morbidity, and degree of disease control are the major drivers of its clinical and economic impact. National scientific societies are required to monitor the application of international guidelines and to adopt strategies to improve disease control and better allocate resources. AIM: to provide a detailed picture of the characteristics of asthma patients and modalities of asthma management by specialists in Italy and to develop recommendations for the daily management of asthma in a specialist setting...
June 2017: Pulmonary Pharmacology & Therapeutics
E Muddiman, A D Bullock, J MacDonald, L Allery, K L Webb, L Pugsley
OBJECTIVES: An increase in patients with long-term conditions and complex care needs presents new challenges to healthcare providers around the developed world. In response, more broad-based training programmes have developed to better prepare trainees for the changing landscape of healthcare delivery. This paper focuses on qualitative elements of a longitudinal, mixed-methods evaluation of the postgraduate, post-Foundation Broad-Based Training (BBT) programme in England. It aims to provide a qualitative analysis of trainees' evaluations of whether the programme meets its intentions to develop practitioners adept at managing complex cases, patient focused care, specialty integration and conviction in career choice...
September 6, 2016: BMJ Open
Christina Tischer, Fabian Weikl, Alexander J Probst, Marie Standl, Joachim Heinrich, Karin Pritsch
BACKGROUND: Investigations in urban areas have just begun to explore how the indoor dust microbiome may affect the pathogenesis of asthma and allery. OBJECTIVE: We aimed to investigate the early fungal and bacterial microbiome in house dust with allergic sensitization and wheezing later in childhood. METHODS: Individual dust samples from 189 homes of the LISAplus birth cohort study were collected shortly after birth from living room floors and profiled for fungal and bacterial microbiome...
December 2016: Environmental Health Perspectives
Lynne A Allery
No abstract text is available yet for this article.
May 2016: Education for Primary Care
A Finall, L Allery
AIMS: This is a qualitative study of the perceived learning needs of trainees for graded responsibility in histopathological training in the UK. METHODS: A focus group with trainees and interviews with consultants was carried out. Participants were asked 'What do you perceive are the learning needs of histopathology trainees to develop skills for safe and confident independent reporting in surgical histopathology?' Data was analysed using open coding content analysis for items relating to training content and structure...
January 2016: Journal of Clinical Pathology
Anand Prakash Swayamprakasam, Ashvina Segaran, Lynne Allery
Work-based assessments (WBAs) were only recently introduced into medicine. However, since their introduction, they have rapidly grown in popularity. WBAs are now a routine part of medical training. As WBAs are being implemented, the practical difficulties with their use have come to light. A major problem is failure of the trainees, trainers and training programmes to adequately engage with them. In this review, the reasons for this and how these can be overcome are discussed.
March 2014: JRSM Open
Harish Thampy, Steven Agius, Lynne Allery
BACKGROUND: In all medical specialities, trainees are increasingly encouraged to develop teaching skills alongside their clinical professional development. However, there have been few empirical UK-based studies that have examined trainees' attitudes and understanding of their own engagement with educational activities. This study therefore aimed to explore this in the context of general practitioner (GP) training using a qualitative approach. METHODS: Twenty GP registrars from the North Western Deanery were recruited to four focus groups...
June 2014: Clinical Teacher
Lynne Allery
No abstract text is available yet for this article.
January 2014: Education for Primary Care
Monia Bardelli, Liliana Alleri, Francesca Angiolini, Francesca Buricchi, Simona Tavarini, Chiara Sammicheli, Sandra Nuti, Elena Degl'Innocenti, Isabelle Isnardi, Elena Fragapane, Giuseppe Del Giudice, Flora Castellino, Grazia Galli
Understanding the impact that human memory B-cells (MBC), primed by previous infections or vaccination, exert on neutralizing antibody responses against drifted influenza hemagglutinin (HA) is key to design best protective vaccines. A major obstacle to these studies is the lack of practical tools to analyze HA-specific MBCs in human PBMCs ex vivo. We report here an efficient method to identify MBCs carrying HA-specific BCR in frozen PBMC samples. By using fluorochrome-tagged recombinant HA baits, and vaccine antigens from mismatched influenza strains to block BCR-independent binding, we developed a protocol suitable for quantitative, functional and molecular analysis of single MBCs specific for HA from up to two different influenza strains in the same tube...
2013: PloS One
Harish Thampy, Steven Agius, Lynne A Allery
The General Medical Council (GMC) states that teaching should be an integral part of the doctor's role and the Royal College of General Practitioners (RCGP) have incorporated teaching outcomes into the GP training curriculum. However, there are suggestions that the teaching role of a GP trainee declines as they move from hospital posts to the registrar community year. Using doctors in training as near-peer tutors offers multiple advantages. Trainees themselves benefit as teaching others is a strong driver of the tutor's own learning...
July 2013: Education for Primary Care
Lynne Allery
No abstract text is available yet for this article.
November 2012: Education for Primary Care
Annette M Boyle
No abstract text is available yet for this article.
August 25, 2011: Medical Economics
Sverrir Gauti Ríkardsson, Yrsa B Löve, Gudmundur H Jörgensen, Davíd Gíslason, Björn Rúnar Lúdvíksson
INTRODUCTION: The prevelance of allery and asthma has increased rapidly over the last 3 decades and is now estimated that 25-30% of population in Western industrialized countries show symptoms of allergy or asthma. The aim of this study was to reveal the success of allergen immunotherapy (AIT) in Landspitali from 1977-2006. MATERIAL AND METHODS: During the study period a total number of 289 individuals underwent immunotherapy in outpatient clinic of allergy and asthma in Landspítali...
July 2010: Læknablađiđ
Lynne Allery
Healthcare professionals have a key role to play in achieving consensus on the essential stages involved in undertaking practical and procedural skills. Providing opportunities for the trainee to practise is vital, as is regular critical scrutiny of performance, coupled with constructive feedback. Teaching procedural skills is a core role for many healthcare teachers. It is vital that trainers consider approaches to teaching skills, and the requirements for achieving skill mastery to ensure patient safety and ensure the training of competent clinicians for the future...
January 2009: Education for Primary Care
Kyle J Muus, Twyla Baker-Demaray, Leander R McDonald, Richard L Ludtke, Alan J Allery, T Andy Bogart, Jack Goldberg, Scott D Ramsey, Dedra S Buchwald
CONTEXT: Regular screenings are important for reducing cancer morbidity and mortality. There are several barriers to receiving timely cancer screening, including overweight/obesity. No study has examined the relationship between overweight/obesity and cancer screening among American Indian/Alaska Natives (AI/ANs). PURPOSE: To describe the prevalence of fecal occult blood testing (FOBT) and prostate-specific antigen (PSA) testing among AI/AN men within the past year by age and rurality, and determine if body mass index (BMI) is associated with screening...
2009: Journal of Rural Health
Joelle C Ruthig, Alan Allery
Addressing the need to explore how Native American (NA) elders' subjective health (SH) compares to their objective health (OH; chronic disease conditions), we examined whether: congruence between 8191 NA elders' SH and OH parallels that of non-NA elders; health optimism (SH > OH) is protective and health pessimism (SH < OH), is detrimental; and whether gender moderates links between health congruence and health-related outcomes. Results comparing health optimists and pessimists to realists in functioning, hospitalizations, and social engagement showed optimists experienced better outcomes; pessimists had poorer outcomes; the role of health congruence differed by gender...
November 2008: Journal of Health Psychology
Lesley Pugsley, Stephen Brigley, Lynne Allery, Janet Macdonald
BACKGROUND: In the United Kingdom the medical teacher role is being formalized. One result is that Masters level programmes in medical education are proliferating; however little or no attempt has been made to capture any differences in quality offered by them. A small scale project (Allery et al. 2006) set out to rectify this omission. AIM: Drawing on data from that study, this paper considers the variation in standards across programmes. Specifically research methods training provided in MMEd courses and levels of support for researchers is investigated...
February 2008: Medical Teacher
Lesley Pugsley, Stephen Brigley, Lynne Allery, Janet MacDonald
CONTEXT: The Association for the Study of Medical Education states that its aim is to improve the quality of medical education. As a consequence, it commissioned through its Education Research Group a small-scale project to explore the quality of the research methods elements in currently available UK master's and doctoral programmes. OBJECTIVE: This study aimed to explore the breadth, depth and diversity of the research methods provision of those programmes currently available to course participants...
February 2008: Medical Education
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