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https://www.readbyqxmd.com/read/28422977/defining-the-complex-phenotype-of-severe-systemic-loxoscelism-using-a-large-electronic-health-record-cohort
#1
Jamie R Robinson, Vanessa E Kennedy, Youssef Doss, Lisa Bastarache, Joshua Denny, Jeremy L Warner
OBJECTIVE: Systemic loxoscelism is a rare illness resulting from the bite of the recluse spider and, in its most severe form, can lead to widespread hemolysis, coagulopathy, and death. We aim to describe the clinical features and outcomes of the largest known cohort of individuals with moderate to severe loxoscelism. METHODS: We performed a retrospective, cross sectional study from January 1, 1995, to December 31, 2015, at a tertiary-care academic medical center, to determine individuals with clinical records consistent with moderate to severe loxoscelism...
2017: PloS One
https://www.readbyqxmd.com/read/28411932/arthropod-envenomation-in-north-america
#2
REVIEW
Timothy B Erickson, Navneet Cheema
Arthropods (phylum Arthopoda) account for a higher percentage of morbidity and mortality to humans than do mammalian bites, snake bites, or marine envenomation. They are ubiquitous in domestic dwellings, caves, and campsites and in wilderness settings such as deserts, forests, and lakes. Although arthropods are most intrusive during warmer months, many are active throughout the winter, particularly indoors. Arthropods are also nocturnal and often bite unsuspecting victims while they are sleeping. Encounters with humans are generally defensive, accidental, or reactive...
May 2017: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/28408204/distribution-and-medical-aspects-of-loxosceles-rufescens-one-of-the-most-invasive-spiders-of-the-world-araneae-sicariidae
#3
REVIEW
Wolfgang Nentwig, Paolo Pantini, Richard S Vetter
Loxosceles rufescens is a circum-Mediterranean spider species, potentially harmful to humans. Its native area covers the Mediterranean Basin and Near East. Easily spread with transported goods, it is meanwhile an alien and invasive species to nearly all other continents and many islands. This species occurs in semi-arid steppe-like habitats, typically under stones and in cavities, which enables it to settle inside buildings when invading the synanthropic environment. This review analyses the literature of L...
April 10, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28396776/tularemia-presenting-as-suspected-necrotic-arachnidism
#4
Heather F Sateia, Michael T Melia, Joseph Cofrancesco
The true danger of the spider bite stems from misdiagnosis and resultant delay in proper treatment of entities that, unlike spider bites, are not self-limited. Obtaining a complete exposure and travel history is central to the development of an accurate and appropriate differential diagnosis.
April 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28396739/nephrotic-syndrome-due-to-minimal-change-disease-secondary-to-spider-bite-clinico-pathological-case-of-a-non-described-complication-of-latrodectism
#5
Gonzalo P Méndez, Daniel Enos, José Luis Moreira, Fátima Alvaredo, David Oddó
The patient was an 18-year-old man who developed nephrotic syndrome after a 'wheat spider' bite (Latrodectus mactans). Due to this atypical manifestation of latrodectism, a renal biopsy was performed showing minimal change disease. The nephrotic syndrome subsided after 1 week without specific treatment. This self-limited evolution suggests that the mechanism of podocyte damage was temporary and potentially mediated by a secondary mechanism of hypersensitivity or direct effect of the α-latrotoxin. The patient did not show signs of relapse in subsequent checkup...
April 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28379166/phospholipase-d-from-loxosceles-laeta-spider-venom-induces-il-6-il-8-cxcl1-gro-%C3%AE-and-ccl2-mcp-1-production-in-human-skin-fibroblasts-and-stimulates-monocytes-migration
#6
José M Rojas, Tomás Arán-Sekul, Emmanuel Cortés, Romina Jaldín, Kely Ordenes, Patricio R Orrego, Jorge González, Jorge E Araya, Alejandro Catalán
Cutaneous loxoscelism envenomation by Loxosceles spiders is characterized by the development of a dermonecrotic lesion, strong inflammatory response, the production of pro-inflammatory mediators, and leukocyte migration to the bite site. The role of phospholipase D (PLD) from Loxosceles in the recruitment and migration of monocytes to the envenomation site has not yet been described. This study reports on the expression and production profiles of cytokines and chemokines in human skin fibroblasts treated with catalytically active and inactive recombinant PLDs from Loxosceles laeta (rLlPLD) and lipid inflammatory mediators ceramide 1-phosphate (C1P) and lysophosphatidic acid (LPA), and the evaluation of their roles in monocyte migration...
April 5, 2017: Toxins
https://www.readbyqxmd.com/read/28259053/reconstructive-considerations-following-a-necrotic-spider-bite-on-the-face-a-case-report
#7
Joachim Mikkelsen, Grethe Schmidt, Rikke Holmgaard
INTRODUCTION: Spider bites as the cause of necrotic skin and soft tissue lesions occur very rarely in Central and Northern Europe. Recluse spiders, distributed almost worldwide, are one of two genera of spiders with confirmed capability of causing necrotic lesions. In the facial region, the resulting defects represent a potential reconstructive challenge, especially in younger patients. METHODS: This case report has been reported in line with the SCARE criteria...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28246022/toxicity-of-the-venom-of-latrodectus-araneae-theridiidae-spiders-from-different-regions-of-argentina-and-neutralization-by-therapeutic-antivenoms
#8
Adolfo Rafael de Roodt, Laura Cecilia Lanari, Rodrigo Daniel Laskowicz, Vanessa Costa de Oliveira, Lucia Elvira Irazu, Alda González, Luis Giambelluca, Néstor Nicolai, Javier Hugo Barragán, Leticia Ramallo, Raúl Alfredo López, Jorge Lopardo, Oscar Jensen, Edmundo Larrieu, Arnoldo Calabró, Miriam Guadalupe Vurcharchuc, Néstor Rubén Lago, Susana Isabel García, Ernesto Horacio de Titto, Carlos Fabián Damín
"Black widow" spiders belong to the genus Latrodectus and are one of the few spiders in the world whose bite can cause severe envenomation in humans and domestic animals. In Argentina, these spiders are distributed throughout the country and are responsible for the highest number of bites by spiders of toxicological sanitary interest. Here, we studied the toxicity and some biochemical and immunochemical characteristics of eighteen venom samples from Latrodectus spiders from eight different provinces of Argentina, and the neutralization of some of these samples by two therapeutic antivenoms used in the country for the treatment of envenomation and by a anti-Latrodectus antivenom prepared against the venom of Latrodectus mactans from Mexico...
May 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28199453/not-recluse-a-mnemonic-device-to-avoid-false-diagnoses-of-brown-recluse-spider-bites
#9
William V Stoecker, Richard S Vetter, Jonathan A Dyer
No abstract text is available yet for this article.
February 15, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28194160/highlights-in-the-knowledge-of-brown-spider-toxins
#10
REVIEW
Daniele Chaves-Moreira, Andrea Senff-Ribeiro, Ana Carolina Martins Wille, Luiza Helena Gremski, Olga Meiri Chaim, Silvio Sanches Veiga
Brown spiders are venomous arthropods that use their venom for predation and defense. In humans, bites of these animals provoke injuries including dermonecrosis with gravitational spread of lesions, hematological abnormalities and impaired renal function. The signs and symptoms observed following a brown spider bite are called loxoscelism. Brown spider venom is a complex mixture of toxins enriched in low molecular mass proteins (4-40 kDa). Characterization of the venom confirmed the presence of three highly expressed protein classes: phospholipases D, metalloproteases (astacins) and insecticidal peptides (knottins)...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28076265/nonbacterial-causes-of-lymphangitis-with-streaking
#11
Brandon E Cohen, Arielle R Nagler, Miriam Keltz Pomeranz
BACKGROUND: Lymphangitic streaking, characterized by linear erythema on the skin, is most commonly observed in the setting of bacterial infection. However, a number of nonbacterial causes can result in lymphangitic streaking. We sought to elucidate the nonbacterial causes of lymphangitic streaking that may mimic bacterial infection to broaden clinicians' differential diagnosis for patients presenting with lymphangitic streaking. METHODS: We performed a review of the literature, including all available reports pertaining to nonbacterial causes of lymphangitic streaking...
November 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28017694/pitfalls-to-avoid-when-using-phage-display-for-snake-toxins
#12
Andreas Hougaard Laustsen, Line Præst Lauridsen, Bruno Lomonte, Mikael Rørdam Andersen, Brian Lohse
Antivenoms against bites and stings from snakes, spiders, and scorpions are associated with immunological side effects and high cost of production, since these therapies are still derived from the serum of hyper-immunized production animals. Biotechnological innovations within envenoming therapies are thus warranted, and phage display technology may be a promising avenue for bringing antivenoms into the modern era of biologics. Although phage display technology represents a robust and high-throughput approach for the discovery of antibody-based antitoxins, several pitfalls may present themselves when animal toxins are used as targets for phage display selection...
December 23, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28017625/first-case-of-dress-syndrome-attributed-to-a-spider-bite
#13
Alexia Eyraud, Lucile Boursault, Anne-Sophie Darrigade, Alain Taieb, Brigitte Milpied
No abstract text is available yet for this article.
December 22, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27846029/nonhealing-wounds-caused-by-brown-spider-bites-application-of-hyperbaric-oxygen-therapy
#14
Amir Hadanny, Gregory Fishlev, Yair Bechor, Oshra Meir, Shai Efrati
BACKGROUND: Bites by Loxosceles spiders (also known as recluse spiders or brown spiders) can cause necrotic ulcerations of various sizes and dimensions. The current standard of care for brown spider bites includes analgesics, ice, compression, elevation, antihistamines, and surgical debridement. Hyperbaric oxygen therapy (HBOT) in the treatment of brown spider bites has been administered in the early stage of ulceration, or 2 to 6 days after the bite. Unfortunately, the diagnosis of spider bite-related ulcers is often delayed and weeks or months may elapse before HBOT is considered...
December 2016: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/27798387/a-15-year-old-boy-with-progressive-weakness-after-a-spider-bite
#15
Emily J Ciccone, Robert B Christian, Daniel M Lercher, Kenya McNeal-Trice, Benny L Joyner
No abstract text is available yet for this article.
October 18, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27749012/injury-trends-from-envenoming-in-australia-2000-2013
#16
R E Welton, D J Williams, D Liew
BACKGROUND: Accidental injury is a major public health problem in developed countries with 20 years elapsed since a national overview of venomous bites undertaken in Australia. AIM: Provide the first contemporary epidemiological insight into venomous injuries based on demographics and geography nationally in Australia in the period 2000-2013. METHODS: An analysis of national hospitalisation and mortality data was undertaken to examine the incidence of injury and death due to envenoming in Australia...
February 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/27699754/-tarantism-in-spain-in-the-eighteen-century-latrodectism-and-suggestion
#17
REVIEW
I Corral-Corral, C Corral-Corral
INTRODUCTION: Tarantism is the disease caused by the bite of the tarantula, in which the music tarantella triggers an involuntary dance. It is known in Italy since the sixteenth century. AIM: To analyze the tarantism reported in Spain at the end of the eighteenth century, with special attention to its neurological aspects, and to propose its medical and psychopathological explanation. DEVELOPMENT: An epidemic of people affected by the tarantula bite occurred in Spain in 1782...
October 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27692235/-cutaneous-loxoscelism-about-an-exceptional-observation-of-9-consecutive-cases
#18
F Boissiere, R Masson, S Fluieraru, J Vitse, L Dessena, M Lefevre, F Bekara, C Herlin
INTRODUCTION: Loxosceles spiders are ubiquitous and responsible for many cases of envenomation in the world. The kind rufescens is present in the Provence and Occitan regions in France. During the summer 2015, we faced many Loxosceles rufescens cases of bites having led to extensive integumental necrosis whose features and singular evolution seems important to report. MATERIAL AND METHODS: We report the cases of nine patients who experienced a spider bite in the summer of 2015 in the Languedoc Roussillon...
December 2016: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/27685512/an-interesting-case-of-intracerebral-mrsa
#19
Robert Estridge, Shawnelle Contini
This article describes a patient whose intracerebral MRSA may have been caused by a spider bite to the thigh 2 months earlier. The patient's headache, nausea, and vomiting initially were thought to be caused by a high-grade glioma. Most brain abscesses have otogenic sources and are not from distant hematogenous spread. Although systemic antibiotics help with symptomatology, surgical eradication (when feasible) followed by IV antibiotics, provides definitive treatment.
October 2016: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/27651958/spider-bite-a-rare-case-of-acute-necrotic-arachnidism-with-rapid-and-fatal-evolution
#20
Mario Pezzi, Anna Maria Giglio, Annamaria Scozzafava, Orazio Filippelli, Giuseppe Serafino, Mario Verre
The spider bites are quite frequent and often resolve quickly without leaving outcomes; only some species are capable of causing necrotic and systematic lesions in humans. Among them, we should mention the genus Loxosceles. The venom released from the spider bite of Loxosceles species is composed of proteins, enzymes, and nonenzymatic polypeptides. The phospholipase D family was identified as the active component of the venom. This family of enzymes is responsible for the local and systemic effects observed in loxoscelism...
2016: Case Reports in Emergency Medicine
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