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https://www.readbyqxmd.com/read/29790305/lyme-disease-associated-igg4-autoantibodies-correlate-with-synovial-pathology-in-antibiotic-refractory-lyme-arthritis
#1
Katherine B Sulka, Klemen Strle, Jameson T Crowley, Robert B Lochhead, Robert Anthony, Allen C Steere
OBJECTIVE: To determine whether IgG subclasses of B. burgdorferi antibodies differ from those of 3 Lyme disease (LD)-associated autoantibodies. METHODS: The IgG antibody subclasses were determined by ELISA in serum samples from 215 patients representative of each of the 3 stages of Lyme disease. Antibody and cytokine profiles were measured in matched serum and synovial fluid (SF) samples from Lyme arthritis patients. Synovial tissue from patients with antibiotic-refractory arthritis was examined for histologic features, IgG subclasses of plasma cells, and mRNA subclass expression...
May 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29789953/update-on-tick-borne-bacterial-diseases-in-travelers
#2
REVIEW
Carole Eldin, Philippe Parola
PURPOSE OF REVIEW: Ticks are the second most important vectors of infectious diseases after mosquitoes worldwide. The growth of international tourism including in rural and remote places increasingly exposes travelers to tick bite. Our aim was to review the main tick-borne infectious diseases reported in travelers in the past 5 years. RECENT FINDINGS: In recent years, tick-borne bacterial diseases have emerged in travelers including spotted fever group (SFG) rickettsioses, borrelioses, and diseases caused by bacteria of the Anaplasmataceae family...
May 22, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29789489/reconciling-the-entomological-hazard-and-disease-risk-in-the-lyme-disease-system
#3
Max McClure, Maria Diuk-Wasser
Lyme disease (LD) is a commonly cited model for the link between habitat loss and/or fragmentation and disease emergence, based in part on studies showing that forest patch size is negatively related to LD entomological risk. An equivalent relationship has not, however, been shown between patch size and LD incidence (LDI). Because entomological risk is measured at the patch scale, while LDI is generally assessed in relation to aggregate landscape statistics such as forest cover, we posit that the contribution of individual patches to human LD risk has not yet been directly evaluated...
May 22, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29788994/tick-abundance-pathogen-prevalence-and-disease-incidence-in-two-contrasting-regions-at-the-northern-distribution-range-of-europe
#4
Atle Mysterud, Vetle Malmer Stigum, Ingrid Vikingsdal Seland, Anders Herland, W Ryan Easterday, Solveig Jore, Olav Østerås, Hildegunn Viljugrein
BACKGROUND: Emergence of tick-borne diseases is impacting humans and livestock across the Northern Hemisphere. There are, however, large regional variations in number of cases of tick-borne diseases. Some areas have surprisingly few cases of disease compared to other regions. The aim here is to provide a first step towards a better understanding of such contrasting regional patterns of disease emergences at the northern distribution range of Ixodes ricinus in Europe. METHODS: We compare disease incidence, vector abundance and pathogen prevalence in eastern and western Norway differing in the number of tick-borne disease cases...
May 22, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29776377/shifts-in-borrelia-burgdorferi-s-l-geno-species-infections-in-ixodes-ricinus-over-a-10-year-surveillance-period-in-the-city-of-hanover-germany-and-borrelia-miyamotoi-specific-reverse-line-blot-detection
#5
Katrin Blazejak, Marie-Kristin Raulf, Elisabeth Janecek, Daniela Jordan, Volker Fingerle, Christina Strube
BACKGROUND: Lyme borreliosis caused by spirochetes of the Borrelia burgdorferi (sensu lato) complex is still the most common tick-borne disease in Europe, posing a considerable threat to public health. The predominant vector in Europe is the widespread hard tick Ixodes ricinus, which also transmits the relapsing fever spirochete B. miyamotoi as well as pathogenic Rickettsiales (Anaplasma phagocytophilum, Rickettsia spp.). To assess the public health risk, a long-term monitoring of tick infection rates with the named pathogens is indispensable...
May 18, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29774138/clinical-evaluation-of-morgellons-disease-in-a-cohort-of-north-american-patients
#6
Melissa C Fesler, Marianne J Middelveen, Raphael B Stricker
Morgellons disease (MD) is a dermatological condition characterized by aberrant production of keratin and collagen fibers in skin. Although infection with Borrelia burgdorferi , the causative agent of Lyme disease (LD), has been associated with MD, relatively few studies have hitherto provided epidemiological evidence regarding this association. A cohort of 1000 seropositive North American LD patients was evaluated for the presence of MD. Patients were diagnosed with MD based on detection of microscopic fibers in skin lesions or under unbroken skin...
April 23, 2018: Dermatology Reports
https://www.readbyqxmd.com/read/29771396/lyme-arthritis-of-the-pediatric-elbow-a-case-series
#7
David Gendelberg, William L Hennrikus
Most patients with untreated Lyme disease will experience joint symptoms. Owing to their resemblance in clinical presentation, Lyme arthritis and septic arthritis are often difficult to differentiate. However, their treatment is different. The elbow is rarely the first joint to present with symptoms. Therefore, Lyme disease is not commonly included in the differential diagnosis for children presenting with isolated elbow pain. The authors report 4 cases of monoarticular Lyme arthritis presenting in the elbow...
May 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29770048/synopsis-lyme-disease-in-canada-a-federal-framework
#8
(no author information available yet)
The Federal Framework on Lyme Disease Act required the federal government to develop a Federal Framework on Lyme Disease. To do this, the Public Health Agency of Canada held a conference with a wide variety of stakeholders who shared their experiences with Lyme disease, and discussed current knowledge and research. A draft version of the Framework was publicly posted on Canada.ca for a 30-day public consultation period. The final report, Lyme Disease in Canada: A Federal Framework was released in May 2017. The Framework includes the three pillars of surveillance; education and awareness; and guidelines and best practices...
October 5, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770047/emerging-infectious-diseases-prediction-and-detection
#9
N H Ogden, P AbdelMalik, Jrc Pulliam
Emerging infectious diseases (EIDs), including West Nile virus, severe acute respiratory syndrome (SARS) and Lyme disease, have had a direct effect within Canada, while many more EIDs such as Zika, chikungunya and Ebola are a threat to Canadians while travelling. Over 75% of EIDs affecting humans are, or were originally, zoonoses (infectious diseases transmitted from animals to humans). There are two main ways by which infectious diseases can emerge: by changes in their geographical ranges and by adaptive emergence, a genetic change in a microorganism that results in it becoming capable of invading a new niche, often by jumping to a new host species such as humans...
October 5, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770045/surveillance-for-lyme-disease-in-canada-2009-2015
#10
S Gasmi, N H Ogden, L R Lindsay, S Burns, S Fleming, J Badcock, S Hanan, C Gaulin, M A Leblanc, C Russell, M Nelder, L Hobbs, S Graham-Derham, L Lachance, A N Scott, E Galanis, J K Koffi
Objective: To summarize seven years of surveillance data for Lyme disease cases reported in Canada from 2009 to 2015. Methods: We describe the incidence over time, seasonal and geographic distribution, demographic and clinical characteristics of reported Lyme disease cases. Logistic regression was used to explore differences between age groups, sex and year to better understand potential demographic risk factors for the occurrence of Lyme disease. Results: The number of reported Lyme disease cases increased more than six-fold, from 144 in 2009 to 917 in 2015, mainly due to an increase in infections acquired in Canada...
October 5, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29763485/what-s-eating-you-ixodes-tick-and-related-diseases-part-2-diagnosis-and-treatment-of-regional-tick-borne-diseases
#11
Kelsey D Wilson, Dirk M Elston
The Ixodes tick is an important arthropod vector in the transmission of human disease. Although Lyme disease is the most prevalent zoonosis transmitted by Ixodes ticks, other less common diseases may be encountered, including human granulocytic anaplasmosis, babesiosis, Powassan virus infection, tick-borne encephalitis, Borrelia miyamotoi disease, and tick paralysis. In part 2 of this review, disease presentation, diagnosis, and treatment of these less commonly encountered tick-borne diseases are discussed.
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29746483/efficient-detection-of-symptomatic-and-asymptomatic-patient-samples-for-babesia-microti-and-borrelia-burgdorferi-infection-by-multiplex-qpcr
#12
Shekerah Primus, Lavoisier Akoolo, Samantha Schlachter, Kristine Gedroic, Albert D Rojtman, Nikhat Parveen
BACKGROUND: Tick-borne infections have been increasing steadily over the years, with co-infections with Borrelia burgdorferi and Babesia microti/divergens emerging as a serious health problem. B. burgdorferi is a spirochetal bacterium that causes Lyme disease while protozoan pathogens belonging to Babesia species are responsible for babesiosis. Currently used serological tests do not always detect acute Lyme disease or babesiosis, and fail to differentiate cured patients from those who get re-infected...
2018: PloS One
https://www.readbyqxmd.com/read/29745726/lyme-disease-co-infections-role-of-adaptive-immune-system
#13
Alexis Lacout, Juliette Thariat, Mostafa El Hajjam, Pierre Yves Marcy, Christian Perronne
No abstract text is available yet for this article.
May 10, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29743307/evaluation-of-modified-two-tiered-testing-algorithms-for-lyme-disease-laboratory-diagnosis-using-well-characterized-serum-samples
#14
Adoracion Pegalajar-Jurado, Martin E Schriefer, Ryan J Welch, Marc R Couturier, Tiffany MacKenzie, Rebecca J Clark, Laura V Ashton, Mark J Delorey, Claudia R Molins
Standard two-tiered testing (STTT) is the recommended algorithm for laboratory diagnosis of Lyme disease (LD). Several limitations are associated with STTT that include low sensitivity in the early stages of disease, as well as technical complexity and subjectivity associated with second-tier immunoblots; therefore, modified two-tiered testing (MTTT) algorithms that utilize two sequential first-tier tests and eliminate immunoblots have been evaluated. Recently, a novel MTTT that uses a VlsE chemiluminescence immunoassay followed by a C6 enzyme immunoassay has been proposed...
May 9, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29741589/c-reactive-protein-response-in-patients-with-post-treatment-lyme-disease-symptoms-versus-those-with-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#15
Melanie Uhde, Alyssa Indart, Brian A Fallon, Gary P Wormser, Adriana R Marques, Suzanne D Vernon, Armin Alaedini
No abstract text is available yet for this article.
May 8, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29739424/influence-of-climatic-factors-on-ixodes-ricinus-nymph-abundance-and-phenology-over-a-long-term-monthly-observation-in-switzerland-2000-2014
#16
Gaël Hauser, Olivier Rais, Francisca Morán Cadenas, Yves Gonseth, Mahmoud Bouzelboudjen, Lise Gern
BACKGROUND: One of the major public health challenges in the field of communicable diseases consists of being able to predict where and when a population is at risk of being infected by a pathogen. In the case of vector-borne diseases, such predictions often require strong ecological knowledge of the vector life-cycle and the environmental conditions promoting or preventing its establishment and maintenance. In this study, we analyse how climatic factors influence the abundance and phenology of the Lyme borreliosis vector Ixodes ricinus in a Swiss temperate forest, based on a long-term monthly observation over a period of 15 years (2000 and 2014)...
May 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29738078/tick-borne-disease-risk-in-a-forest-food-web
#17
Richard S Ostfeld, Taal Levi, Felicia Keesing, Kelly Oggenfuss, Charles D Canham
Changes to the community ecology of hosts for zoonotic pathogens, particularly rodents, are likely to influence the emergence and prevalence of zoonotic diseases worldwide. However, the complex interactions between abiotic factors, pathogens, vectors, hosts, and both food resources and predators of hosts are difficult to disentangle. Here we (1) use 19 years of data from six large field plots in southeastern New York to compare the effects of hypothesized drivers of interannual variation in Lyme disease risk, including the abundance of acorns, rodents, and deer, as well as a series of climate variables; and (2) employ landscape epidemiology to explore how variation in predator community structure and forest cover influences spatial variation in the infection prevalence of ticks for the Lyme disease bacterium, Borrelia burgdorferi, and two other important tick-borne pathogens, Anaplasma phagocytophilum and Babesia microti...
May 8, 2018: Ecology
https://www.readbyqxmd.com/read/29731651/a-case-of-lyme-disease-in-a-japanese-woman
#18
Masafumi Seki, Yuji Watanabe, Hiroki Kawabata
This report presents the case of a Japanese patient who developed Lyme disease. The patient was a 44-year-old woman who had general fatigue and the inability to open her mouth. She was initially suspected of having mild tetanus with lockjaw; however, she reported a past history of a tick bite while camping in the USA and had erythema migrans 2 months before this visit. Finally, Lyme disease was serologically confirmed. A few cases of Lyme disease are annually reported in Japan; however, this infectious disease should also be suspected...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29724873/early-disseminated-lyme-disease
#19
Patrick D Bender, Jonathan S Ilgen
No abstract text is available yet for this article.
May 2, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29723263/borrelia-burgdorferi-adhere-to-blood-vessels-in-the-dura-mater-and-are-associated-with-increased-meningeal-t-cells-during-murine-disseminated-borreliosis
#20
Ali Divan, Timothy Casselli, S Anand Narayanan, Sanjib Mukherjee, David C Zawieja, John A Watt, Catherine A Brissette, M Karen Newell-Rogers
Borrelia burgdorferi, the causative agent of Lyme disease, is a vector-borne bacterial infection that is transmitted through the bite of an infected tick. If not treated with antibiotics during the early stages of infection, disseminated infection can spread to the central nervous system (CNS). In non-human primates (NHPs) it has been demonstrated that the leptomeninges are among the tissues colonized by B. burgdorferi spirochetes. Although the NHP model parallels aspects of human borreliosis, a small rodent model would be ideal to study the trafficking of spirochetes and immune cells into the CNS...
2018: PloS One
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