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https://www.readbyqxmd.com/read/29352647/ifn-%C3%AE-and-tnf-%C3%AE-pre-licensing-protects-mesenchymal-stromal-cells-from-the-pro-inflammatory-effects-of-palmitate
#1
Lauren Boland, Anthony J Burand, Alex J Brown, Devlin Boyt, Vitor A Lira, James A Ankrum
The use of mesenchymal stromal cell (MSC) therapy for the treatment of type 2 diabetes (T2D) and T2D complications is promising; however, the investigation of MSC function in the setting of T2D has not been thoroughly explored. In our current study, we investigated the phenotype and function of MSCs in a simulated in vitro T2D environment. We show that palmitate, but not glucose, exposure impairs MSC metabolic activity with moderate increases in apoptosis, while drastically affecting proliferation and morphology...
December 19, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29352350/groundwater-quality-assessment-in-semi-arid-regions-using-integrated-approaches-the-case-of-grombalia-aquifer-ne-tunisia
#2
Siwar Kammoun, Rim Trabelsi, Viviana Re, Kamel Zouari, Jihed Henchiri
As many arid and semi-arid regions in the Mediterranean Basin, the Grombalia coastal aquifer (NE Tunisia) is affected by severe groundwater exploitation and contamination. Therefore, quality assessments are becoming increasingly important as the long-term protection of water resources is at stake. Multidisciplinary investigations, like the one presented in this paper, are particularly effective in identifying the different origins of mineralization within an aquifer and investigating the impact of anthropogenic activities on groundwater quality...
January 19, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29352129/molecular-characterization-of-the-grape-seeds-extract-s-effect-against-chemically-induced-liver-cancer-in-vivo-and-in-vitro-analyses
#3
Alaaeldin Ahmed Hamza, Gehan Hussein Heeba, Hanan Mohamed Elwy, Chandraprabha Murali, Raafat El-Awady, Amr Amin
The purpose of this study was to investigate the anti-cancer property of grape seed extract (GSE) during early stages of developing liver cancer using a two-stage carcinogenic model combining diethylnitrosamine (DEN) and 2-Acetyl Aminofluorene (2-AAF). Administration of GSE at doses 25, 50 and 100 mg/kg per day started at the beginning of promotion periods and continued for 14 weeks. GSE dramatically inhibited pre-neoplastic foci formation as well as significantly decreased the number and the area of placental glutathione-S-transferase in livers of DEN-2AAF-treated rats by approximately 4 & 10 fold deductions, respectively...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351671/a-novel-non-invasive-method-for-evaluating-electroencephalograms-on-laying-hens
#4
Krista N Eberle, Michael P Martin, Sanjay Shah, Ramon D Malheiros, Kimberly A Livingston, Kenneth E Anderson
The use of electroencephalograms (EEG) to study the avian brain relative to behavior was conducted as early as the 1960's. EEG readings, combined with visual cues, provide the ability to elucidate and correlate behaviors to neurological and physiological changes in a chicken. The use of EEG recordings in animal models require access to the brain to implant electrodes. Having the ability to observe EEG activity on sensible birds without surgical implantation could broaden the research in this area and give further insight related to the hen's state of awareness...
January 17, 2018: Poultry Science
https://www.readbyqxmd.com/read/29351416/acute-and-chronic-resistance-training-downregulates-select-line-1-retrotransposon-activity-markers-in-human-skeletal-muscle
#5
Matthew A Romero, C Brooks Mobley, Petey W Mumford, Paul A Roberson, Cody T Haun, Wesley C Kephart, James C Healy, Darren T Beck, Kaelin C Young, Jeffrey S Martin, Christopher M Lockwood, Michael D Roberts
Herein, we examined if acute or chronic resistance exercise affected markers of skeletal muscle LINE-1 retrotransposon activity. In study 1, 10 resistance-trained college-aged males performed three consecutive daily back squat sessions, and vastus lateralis biopsies were taken prior to (Pre), 2 h following session 1 (Post1), and 3 days following session 3 (Post2). In study 2, 13 untrained college-aged males performed a full-body resistance training program (3 d/wk), and vastus lateralis biopsies were taken prior to (week 0) and ~72 h following training cessation (week 12)...
December 20, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29351369/heparin-but-not-tissue-plasminogen-activator-improves-outcomes-in-dcd-liver-transplantation-in-a-porcine-model
#6
Amelia J Hessheimer, Marina Vendrell, Javier Muñoz, Ángel Ruíz, Alba Díaz, Luís Flores Sigüenza, Jorge Rodríguez Lanzilotta, Eduardo Delgado Oliver, Jose Fuster, Miquel Navasa, Juan Carlos García-Valdecasas, Pilar Taurá, Constantino Fondevila
BACKGROUND: Ischemic type biliary lesions arise most frequently after DCD liver transplantation and result in high morbidity and graft loss. Many DCD grafts are discarded out of fear for this complication. In theory, microvascular thrombi deposited during donor warm ischemia might be implicated in ITBL pathogenesis. Herein, we aim to evaluate the effects of the administration of either heparin or the fibrinolytic drug TPA as means to improve DCD liver graft quality and potentially avoid ITBL...
January 19, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29351286/socio-economic-determinants-of-physical-activity-across-the-life-course-a-determinants-of-diet-and-physical-activity-dedipac-umbrella-literature-review
#7
Grainne O'Donoghue, Aileen Kennedy, Anna Puggina, Katina Aleksovska, Christoph Buck, Con Burns, Greet Cardon, Angela Carlin, Donatella Ciarapica, Marco Colotto, Giancarlo Condello, Tara Coppinger, Cristina Cortis, Sara D'Haese, Marieke De Craemer, Andrea Di Blasio, Sylvia Hansen, Licia Iacoviello, Johann Issartel, Pascal Izzicupo, Lina Jaeschke, Martina Kanning, Fiona Ling, Agnes Luzak, Giorgio Napolitano, Julie-Anne Nazare, Camille Perchoux, Caterina Pesce, Tobias Pischon, Angela Polito, Alessandra Sannella, Holger Schulz, Chantal Simon, Rhoda Sohun, Astrid Steinbrecher, Wolfgang Schlicht, Ciaran MacDonncha, Laura Capranica, Stefania Boccia
BACKGROUND: To date, the scientific literature on socioeconomic correlates and determinants of physical activity behaviours has been dispersed throughout a number of systematic reviews, often focusing on one factor (e.g. education or parental income) in one specific age group (e.g. pre-school children or adults). The aim of this umbrella review is to provide a comprehensive and systematic overview of the scientific literature from previously conducted research by summarising and synthesising the importance and strength of the evidence related to socioeconomic correlates and determinants of PA behaviours across the life course...
2018: PloS One
https://www.readbyqxmd.com/read/29351226/curcumin-attenuates-on-carbon-tetrachloride-induced-acute-liver-injury-in-mice-via-modulation-of-the-nrf2-ho-1-and-tgf-%C3%AE-1-smad3-pathway
#8
Xinyan Peng, Chongshan Dai, Quanwen Liu, Junke Li, Jingru Qiu
This study aimed to investigate the protective effect of curcumin against carbon tetrachloride (CCl₄)-induced acute liver injury in a mouse model, and to explain the underlying mechanism. Curcumin at doses of 50, 100 and 200 mg/kg/day were administered orally once daily for seven days prior to CCl₄ exposure. At 24 h, curcumin-attenuated CCl₄ induced elevated serum transaminase activities and histopathological damage in the mouse's liver. Curcumin pre-treatment at 50, 100 and 200 mg/kg significantly ameliorated CCl₄-induced oxidative stress, characterized by decreased malondialdehyde (MDA) formations, and increased superoxide dismutase (SOD), catalase (CAT) activities and glutathione (GSH) content, followed by a decrease in caspase-9 and -3 activities...
January 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29351162/potentiation-effects-of-the-french-contrast-method-on-the-vertical-jumping-ability
#9
Joseba Andoni Hernández-Preciado, Eneko Baz, Carlos Balsalobre-Fernández, David Marchante, Jordan Santos-Concejero
This study examined the acute effects of the potentiation protocol known as French Contrast Method on the vertical jumping ability measured by a countermovement jump (CMJ). 31 athletes participated in the study (intervention group n=17 and control group n=14). The CMJ height was measured using the IOS application MyJump App 2.0 pre- and post- the French Contrast protocol, which consisted of 3 sets of isometric partial squats, drop jumps, dynamic half-squats and hurdle jumps. The CMJ height improved from its baseline values by 5...
January 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29351127/four-months-of-wearing-a-balance-orthotic-improves-measures-of-balance-and-mobility-among-a-cohort-of-community-living-older-adults
#10
Sean Noah, Cynthia Gibson-Horn, Jennifer L Vincenzo
BACKGROUND AND PURPOSE: The Centers for Disease Control and Prevention estimated that there were 29 million falls and 7 million injuries in 2014 in the United States. Falls, decreased balance, and mobility disability are common in older adults and often result in loss of independence. Finding interventions to address these issues is important, as this age group is growing exponentially. Prior studies indicate balance and mobility can be improved by the balance-based torso-weighting (BBTW) assessment implemented through wear of a balance orthotic (BO)...
January 18, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29350637/clinical-utility-of-eco-color-power-doppler-ultrasonography-and-contrast-enhanced-magnetic-resonance-imaging-for-interpretation-and-quantification-of-joint-synovitis-a-review
#11
Marina Carotti, Vittoria Galeazzi, Francesca Catucci, Marcello Zappia, Francesco Arrigoni, Antonio Barile, Andrea Giovagnoni
With the introduction of new biologics such as anti-TNF-alpha antibodies and other therapies in the treatment of inflammatory arthritis, capable of halting joint destruction and functional disability, there are new pressures on diagnostic and prognostic imaging. Early demonstration of pre-erosive inflammatory features and monitoring of the long-term effects of treatment are becoming increasingly important. Early detection of synovitis offers advantages in terms of allowing early instigation of therapy and may allow the identification of those patients displaying more aggressive disease who might benefit from early intervention with expensive DMARD therapy...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350586/mass-media-representations-of-the-evidence-as-a-possible-deterrent-to-recommending-exercise-for-the-treatment-of-depression-lessons-five-years-after-the-extraordinary-case-of-tread-uk
#12
Panteleimon Ekkekakis, Mark E Hartman, Matthew A Ladwig
Exercise or physical activity are recommended options within stepped-care treatment models for depression. However, few physicians present these options to patients, in part because of the impression that the supporting evidence is weak or inconsistent. We speculate that the coocurrence of "counter-messaging" and deficient critical appraisal may lead to such impressions. We focus on TREAD-UK (ISRCTN16900744), the largest trial to investigate "whether physical activity can be an effective treatment for depression within primary care"...
January 19, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29350575/the-neural-substrates-of-improved-phonological-processing-following-successful-treatment-in-a-case-of-phonological-alexia-and-agraphia
#13
Andrew T DeMarco, Stephen M Wilson, Kindle Rising, Steven Z Rapcsak, Pélagie M Beeson
Phonological deficits are common in aphasia after left-hemisphere stroke, and can have significant functional consequences for spoken and written language. While many individuals improve through treatment, the neural substrates supporting improvements are poorly understood. We measured brain activation during pseudoword reading in an individual through two treatment phases. Improvements were associated with greater activation in residual left dorsal language regions and bilateral regions supporting attention and effort...
January 19, 2018: Neurocase
https://www.readbyqxmd.com/read/29350358/streptomyces-ach-505-triggers-production-of-a-salicylic-acid-analogue-in-the-fungal-pathogen-heterobasidion-abietinum-that-enhances-infection-of-norway-spruce-seedlings
#14
Nadine Keilhofer, Jonny Nachtigall, Andreas Kulik, Margret Ecke, Rüdiger Hampp, Roderich D Süssmuth, Hans-Peter Fiedler, Silvia D Schrey
The necrotrophic fungus Heterobasidion spp. is the causal agent of 'annosum root rot' of Norway spruce. In the presence of the rhizosphere bacterium Streptomyces AcH 505, enhanced colonization of Norway spruce roots with Heterobasidion abietinum 331 has previously been observed. By analyzing dual cultures of H. abietinum 331 and Streptomyces AcH 505 with HPLC, a fungal metabolite was identified that was increased in the presence of Streptomyces AcH 505. Likewise, challenge of H. abietum 331 with common antifungals produced by soil streptomycetes rendered the same effect...
January 19, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29350308/the-ppar%C3%AE-agonist-efatutazone-delays-invasive-progression-and-induces-differentiation-of-ductal-carcinoma-in-situ
#15
Virginie Ory, William B Kietzman, Jacob Boeckelman, Bhaskar V Kallakury, Anton Wellstein, Priscilla A Furth, Anna T Riegel
PURPOSE: Ductal carcinoma in situ (DCIS) is a pre-invasive lesion of the breast considered a precursor of invasive ductal carcinoma. This study aimed to determine whether activated PPARγ acts as a tumor suppressor in human DCIS progression. METHODS: We utilized the high-affinity PPARγ agonist, efatutazone, to activate endogenous PPARγ in a well-defined model for the progression of basal (triple negative) DCIS, MCFDCIS cells, cultured under 2D and 3D conditions...
January 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29350296/use-of-biotechnological-devices-in-the-quantification-of-psychophysiological-workload-of-professional-chess-players
#16
Juan P Fuentes, Santos Villafaina, Daniel Collado-Mateo, Ricardo de la Vega, Narcis Gusi, Vicente Javier Clemente-Suárez
Psychophysiological requirements of chess players are poorly understood, and periodization of training is often made without any empirical basis. For this reason, the aim of the present study was to investigate the psychophysiological response and quantify the player internal load during, and after playing a chess game. The participant was an elite 33 year-old male chess player ranked among the 300 best chess players in the world. Thus, cortical arousal by critical flicker fusion threshold, electroencephalogram by the theta Fz/alpha Pz ratio and autonomic modulation by heart rate variability were analyzed...
January 19, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29349812/drug-promotion-practices-a-review
#17
Nilan T Jacob
Over the years, the pharmaceutical industry has been at the forefront of research and innovation in drug discovery and development. The process of drug discovery extending from pre-clinical studies to multi-centric clinical trials and post-marketing phase is a costly affair running into billions of dollars. On the flip side, not all investigational molecules clear the trial phases and get approved; which puts pressure on the manufacturers to maximise the profit from approved drugs. It is in this key area, the practice of drug promotion plays its role...
January 18, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29349630/developmental-changes-in-serotonergic-modulation-of-gabaergic-synaptic-transmission-and-postsynaptic-gabaa-receptor-composition-in-the-cerebellar-nuclei
#18
Fumihito Saitow, Masatoshi Nagano, Hidenori Suzuki
Outputs from the cerebellar nuclei (CN) are important for generating and controlling movement. The activity of CN neurons is controlled not only by excitatory inputs from mossy and climbing fibers and by γ-aminobutyric acid (GABA)-based inhibitory transmission from Purkinje cells in the cerebellar cortex but is also modulated by inputs from other brain regions, including serotonergic fibers that originate in the dorsal raphe nuclei. We examined the modulatory effects of serotonin (5-HT) on GABAergic synapses during development, using rat cerebellar slices...
January 19, 2018: Cerebellum
https://www.readbyqxmd.com/read/29349512/photobiomodulation-induces-in-vitro-re-epithelialization-via-nitric-oxide-production
#19
Manuela Rizzi, Mario Migliario, Stelvio Tonello, Vincenzo Rocchetti, Filippo Renò
Photobiomodulation is a widely used tool in regenerative medicine thanks to its ability to modulate a plethora of physiological responses. Wound re-epithelialization is strictly regulated by locally produced chemical mediators, such as nitric oxide (NO), a highly reactive free radical generated by the nitric oxide synthase (NOS) enzymatic family. In this study, it has been hypothesized that a 980-nm low-level laser stimulation could increase NO production in human keratinocytes and that such event might be directly related to the re-epithelialization process...
January 18, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29349204/validity-of-a-scale-of-neighbourhood-informal-social-control-relevant-to-pre-schoolers-physical-activity-a-cross-sectional-study
#20
Ester Cerin, Yi Nam Suen, Anthony Barnett, Wendy Y J Huang, Robin R Mellecker
Childhood physical activity (PA) is important for health across the lifespan. Time pre-schoolers spend outdoors, which has been associated with more PA, is likely influenced by parents' perception of neighbourhood informal social control relevant to pre-schoolers' PA, defined as the willingness of neighbours to intervene to ensure social order and a safe community environment for young children's active play. To advance measurement of this construct, we assessed factorial and construct validities of the PA-related neighbourhood informal social control scale for parents of pre-schoolers (PANISC-PP)...
December 2017: SSM—Population Health
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