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https://www.readbyqxmd.com/read/28335546/dietary-protein-and-amino-acid-supplementation-in-inflammatory-bowel-disease-course-what-impact-on-the-colonic-mucosa
#1
REVIEW
Sandra Vidal-Lletjós, Martin Beaumont, Daniel Tomé, Robert Benamouzig, François Blachier, Annaïg Lan
Inflammatory bowel diseases (IBD), after disease onset, typically progress in two cyclically repeated phases, namely inflammatory flare and remission, with possible nutritional status impairment. Some evidence, either from epidemiological, clinical, and experimental studies indicate that the quantity and the quality of dietary protein consumption and amino acid supplementation may differently influence the IBD course according to the disease phases. For instance, although the dietary protein needs for mucosal healing after an inflammatory episode remain undetermined, there is evidence that amino acids derived from dietary proteins display beneficial effects on this process, serving as building blocks for macromolecule synthesis in the wounded mucosal area, energy substrates, and/or precursors of bioactive metabolites...
March 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28335485/intra-amniotic-administration-of-raffinose-and-stachyose-affects-the-intestinal-brush-border-functionality-and-alters-gut-microflora-populations
#2
Sarina Pacifici, Jaehong Song, Cathy Zhang, Qiaoye Wang, Raymond P Glahn, Nikolai Kolba, Elad Tako
This study investigates the effectiveness of two types of prebiotics-stachyose and raffinose-which are present in staple food crops that are widely consumed in regions where dietary Fe deficiency is a health concern. The hypothesis is that these prebiotics will improve Fe status, intestinal functionality, and increase health-promoting bacterial populations in vivo (Gallus gallus). By using the intra-amniotic administration procedure, prebiotic treatment solutions were injected in ovo (day 17 of embryonic incubation) with varying concentrations of a 1...
March 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28335416/supplementation-with-phycocyanobilin-citrulline-taurine-and-supranutritional-doses-of-folic-acid-and-biotin-potential-for-preventing-or-slowing-the-progression-of-diabetic-complications
#3
Mark F McCarty
Oxidative stress, the resulting uncoupling of endothelial nitric oxide synthase (eNOS), and loss of nitric oxide (NO) bioactivity, are key mediators of the vascular and microvascular complications of diabetes. Much of this oxidative stress arises from up-regulated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity. Phycocyanobilin (PhyCB), the light-harvesting chromophore in edible cyanobacteria such as spirulina, is a biliverdin derivative that shares the ability of free bilirubin to inhibit certain isoforms of NADPH oxidase...
March 14, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28334915/salience-and-default-mode-network-dysregulation-in-chronic-cocaine-users-predict-treatment-outcome
#4
Xiujuan Geng, Yuzheng Hu, Hong Gu, Betty Jo Salmeron, Bryon Adinoff, Elliot A Stein, Yihong Yang
While chronic cocaine use is associated with abnormalities in both brain structure and function within and interactions between regions, previous studies have been limited to interrogating structure and function independently, and the detected neural differences have not been applied to independent samples to assess the clinical relevance of results. We investigated consequences of structural differences on resting-state functional connectivity in cocaine addiction and tested whether resting-state functional connectivity of the identified circuits predict relapse in an independent cohort...
February 20, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28334859/neurocognitive-function-of-school-aged-hiv-infected-children-in-enugu-nigeria
#5
Kenechukwu K Iloh, Ifeoma J Emodi, Ngozi S Ibeziako, Anthony N Ikefuna, Agozie C Ubesie, Ogochukwu N Iloh, Gideon C Ilechukwu, Adaeze C Ayuk
Background: Evidence has shown neurocognitive problems often exist among human immunodeficiency virus (HIV)-infected children. There are limited data for children in Nigeria. Methods: This was a cross-sectional study of 100 school-aged perinatally HIV-infected children seen in the paediatric HIV clinic and age/sex-matched controls from the general paediatric clinic. Neuro-cognitive functioning was assessed using the Raven's progressive matrices (RPM) that has been adapted for the Nigerian population...
February 20, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28334687/neurocognitive-status-in-patients-with-newly-diagnosed-brain-tumors-in-good-neurological-condition-the-impact-of-tumor-type-volume-and-location
#6
Philipp Hendrix, Elisa Hans, Christoph J Griessenauer, Andreas Simgen, Joachim Oertel, Julia Karbach
OBJECTIVE: Neurocognitive function is of great importance in patients with brain tumors. Even patients in good neurological condition may suffer from neurocognitive dysfunction that affects their daily living. The purpose of the present study was to identify risk factors for neurocognitive dysfunction in patients suffering from common supratentorial brain tumors with minor neurological deficits. METHODS: A prospective study evaluating neurocognitive dysfunction in patients with a newly-diagnosed brain tumor in good neurological condition was performed at a major German academic institution...
March 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28334483/activities-of-daily-living-trajectories-among-institutionalized-older-adults-a-prospective-study
#7
Huai-Ting Kuo, Kuan-Chia Lin, Chung-Fu Lan, I-Chuan Li
AIMS AND OBJECTIVES: To examine ADL trajectory groups among older residents in Taiwan, and to determine the relative risks of demographic characteristics and health status in explaining the trajectory group of ADL. BACKGROUND: Activity of daily living (ADL) is a crucial indicator of health status for institutionalized older adults. ADL is a dynamic process, and has differences in trajectory groups. DESIGN: This study was a 3-year longitudinal analysis of long-term care (LTC) facility residents in Taiwan...
March 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28334371/comparative-study-of-functional-nasal-reconstruction-using-structural-reinforcement
#8
Waleed H Ezzat, Sara W Liu
Importance: Nasal reconstruction after Mohs surgery is a unique challenge in that it must satisfy both functional and aesthetic goals. Despite some advocacy in the literature for using structural reinforcement to achieve both functional and aesthetic outcomes in soft-tissue reconstruction, no study has validated this claim by comparing reconstruction with and without structural support. Objective: To evaluate the effectiveness of and need for structural reinforcement when reconstructing the nasal alar and sidewall subunits...
March 23, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28334351/effects-of-antenatal-maternal-depressive-symptoms-and-socio-economic-status-on-neonatal-brain-development-are-modulated-by-genetic-risk
#9
Anqi Qiu, Mojun Shen, Claudia Buss, Yap-Seng Chong, Kenneth Kwek, Seang-Mei Saw, Peter D Gluckman, Pathik D Wadhwa, Sonja Entringer, Martin Styner, Neerja Karnani, Christine M Heim, Kieran J O'Donnell, Joanna D Holbrook, Marielle V Fortier, Michael J Meaney
This study included 168 and 85 mother-infant dyads from Asian and United States of America cohorts to examine whether a genomic profile risk score for major depressive disorder (GPRSMDD) moderates the association between antenatal maternal depressive symptoms (or socio-economic status, SES) and fetal neurodevelopment, and to identify candidate biological processes underlying such association. Both cohorts showed a significant interaction between antenatal maternal depressive symptoms and infant GPRSMDD on the right amygdala volume...
March 18, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28334179/bayesian-distributed-lag-interaction-models-to-identify-perinatal-windows-of-vulnerability-in-children-s-health
#10
Ander Wilson, Yueh-Hsiu Mathilda Chiu, Hsiao-Hsien Leon Hsu, Robert O Wright, Rosalind J Wright, Brent A Coull
Epidemiological research supports an association between maternal exposure to air pollution during pregnancy and adverse children's health outcomes. Advances in exposure assessment and statistics allow for estimation of both critical windows of vulnerability and exposure effect heterogeneity. Simultaneous estimation of windows of vulnerability and effect heterogeneity can be accomplished by fitting a distributed lag model (DLM) stratified by subgroup. However, this can provide an incomplete picture of how effects vary across subgroups because it does not allow for subgroups to have the same window but different within-window effects or to have different windows but the same within-window effect...
February 27, 2017: Biostatistics
https://www.readbyqxmd.com/read/28334170/multiple-types-of-memory-and-everyday-functional-assessment-in-older-adults
#11
Jenna Beaver, Maureen Schmitter-Edgecombe
Objective: Current proxy measures for assessing everyday functioning (e.g., questionnaires, performance-based measures, and direct observation) show discrepancies in their rating of functional status. The present study investigated the relationship between multiple proxy measures of functional status and content memory (i.e., memory for information), temporal order memory, and prospective memory in an older adult sample. Method: A total of 197 community-dwelling older adults who did (n = 45) or did not meet (n = 152) criteria for mild cognitive impairment (MCI), completed six different assessments of functional status (two questionnaires, two performance-based tasks, and two direct observation tasks) as well as experimental measures of content memory, prospective memory, and temporal order memory...
February 23, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28334058/benchmarking-outcomes-in-implant-prosthodontics-partial-fixed-dental-prostheses-and-crowns-supported-by-implants-with-a-turned-surface-over-10-to-28-years-at-the-university-of-toronto
#12
Asbjørn Jokstad, Anne M Gussgard, Joseph Fava, Mark Lin, Babak Shokati, Eszter Somogyi-Ganss, Brenton Winnett, Mohammed Zahran
PURPOSE: The aim of this noninterventional, retrospective study was to benchmark the outcomes of patients with partial fixed prostheses supported by implants treated at the University of Toronto at least 10 years earlier. A study protocol for assessing outcomes on like patients developed at the University of Bern, Switzerland, was followed. MATERIALS AND METHODS: All patients who had received at least one implant before 2002 were considered eligible to be included in the study (n = 298)...
March 23, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28333987/genome-scale-identification-of-nucleosome-organization-by-using-1000-porcine-oocytes-at-different-developmental-stages
#13
Chenyu Tao, Juan Li, Baobao Chen, Daming Chi, Yaqiong Zeng, Honglin Liu
The nucleosome is the basic structural unit of chromosomes, and its occupancy and distribution in promoters are crucial for the regulation of gene expression. During the growth process of porcine oocytes, the "growing" oocytes (SF) have a much higher transcriptional activity than the "fully grown" oocytes (BF). However, the chromosome status of the two kinds of oocytes remains poorly understood. In this study, we profiled the nucleosome distributions of SF and BF with as few as 1000 oocytes. By comparing the altered regions, we found that SF tended toward nucleosome loss and more open chromosome architecture than BF did...
2017: PloS One
https://www.readbyqxmd.com/read/28333979/the-interaction-between-fluid-status-and-angiopoietin-2-in-adverse-renal-outcomes-of-chronic-kidney-disease
#14
Yi-Chun Tsai, Yi-Wen Chiu, Hung-Tien Kuo, Jia-Jung Lee, Su-Chu Lee, Tzu-Hui Chen, Ming-Yen Lin, Shang-Jyh Hwang, Mei-Chuan Kuo, Ya-Ling Hsu, Hung-Chun Chen
BACKGROUND: Fluid overload is not only the characteristic but also an important complication in chronic kidney disease (CKD) patients. Angiopoietin-2 (Angpt2) disturbs endothelium and vessel permeability, which may induce fluid overload. The aim of this study is to examine the interaction between fluid status and Angpt2 in adverse renal outcomes of CKD. METHODS: This cohort study enrolled 290 patients with CKD stages 3-5 from January 2011 to December 2011 and followed up until December 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28333901/influence-of-the-recurrent-syncope-episodes-on-neurocognitive-functions-in-patients-with-vasovagal-syncope
#15
Joanna Jędrzejczyk-Spaho, Artur Z Pietrucha, Agnieszka Borowiec, Irena Bzukała, Mateusz Wnuk, Ewa Konduracka, Jadwiga Nessler
The aim of study was to evaluate an influence of recurrent syncope episodes on the neurocognitive functions (NCF) in patients with suspected VVS. AIM: The aim of study was to evaluate an influence of recurrent syncope episodes on the neurocognitive functions (NCF) in patients with suspected VVS. MATERIALS AND METHODS: Study population: 24 pts. (16 women) aged 17-70 yrs (mean age 40 years), with suspected VVS, referred to HUTT (head-up tilt test). All pts. underwent initial evaluation regarding to the number and circumstances of the syncopal and/or presyncopal spells...
March 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28333763/inflammatory-status-and-lung-function-predict-mortality-in-lung-cancer-screening-participants
#16
Ugo Pastorino, Daniele Morelli, Alfonso Marchianò, Stefano Sestini, Paola Suatoni, Francesca Taverna, Mattia Boeri, Gabriella Sozzi, Anna Cantarutti, Giovanni Corrao
Low-dose computed tomography (LDCT) screening trials have based their risk selection algorithm on age and tobacco exposure, but never on pulmonary risk-related biomarkers. In the present study, the baseline inflammatory status, measured by C-reactive protein (CRP) level, and lung function, measured by forced expiratory volume in 1 s (FEV1), were tested as independent predictors of all-cause mortality in LDCT-screening participants. Between 2000 and 2010, 4413 volunteers were enrolled in two LDCT-screening trials, with evaluable baseline CRP and FEV1 values: 2037 were included in the discovery set and 2376 were included in the validation set...
March 22, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28333271/impact-of-thyroid-autoimmunity-in-euthyroid-women-on-live-birth-rate-after-iui
#17
D Unuane, B Velkeniers, B Bravenboer, P Drakopoulos, H Tournaye, J Parra, M De Brucker
STUDY QUESTION: Does thyroid autoimmunity (TAI) predict live birth rate in euthyroid women after one treatment cycle in IUI patients? SUMMARY ANSWER: TAI as such does not influence pregnancy outcome after IUI treatment. WHAT IS KNOWN ALREADY: The role of TAI on pregnancy outcome in the case of IVF/ICSI is largely debated in the literature. This is the first study to address this issue in the case of IUI. STUDY DESIGN, SIZE, DURATION: This was a retrospective cohort study...
February 23, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333093/the-effect-of-regular-intake-of-dry-cured-ham-rich-in-bioactive-peptides-on-inflammation-platelet-and-monocyte-activation-markers-in-humans
#18
Sara María Martínez-Sánchez, Alfredo Minguela, David Prieto-Merino, María Pilar Zafrilla-Rentero, José Abellán-Alemán, Silvia Montoro-García
Background and aims: Dietary studies have shown that active biopeptides provide protective health benefits, although the mediating pathways are somewhat uncertain. To throw light on this situation, we studied the effects of consuming Spanish dry-cured ham on platelet function, monocyte activation markers and the inflammatory status of healthy humans with pre-hypertension. Methods: Thirty-eight healthy volunteers with systolic blood pressure of >125 mmHg were enrolled in a two-arm crossover randomized controlled trial...
March 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28332736/dementia-related-restlessness-relationship-to-characteristics-of-persons-with-dementia-and-family-caregivers
#19
Natalie G Regier, Laura N Gitlin
OBJECTIVE: Dementia-related restlessness is commonly endorsed by caregivers but not well understood. This study examines differences in characteristics (demographics, cognitive status, physical function, pain, and mood) of persons with dementia whose caregivers endorse restlessness versus those who do not. We also examine the relationship of restlessness to caregiver well-being including burden, upset with behaviors, mastery, and depressive symptomatology. METHODS: We combined baseline data from three caregiver intervention studies of community-dwelling persons with dementia who exhibited neuropsychiatric symptoms (n = 569) as measured by the Agitated Behaviors in Dementia Scale...
March 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28332238/outcome-measures-for-adult-and-pediatric-hemophilia-patients-with-inhibitors
#20
REVIEW
Cedric Hermans, Günter Auerswald, Gary Benson, Gerry Dolan, Anne Duffy, Victor Jiménez-Yuste, Rolf Ljung, Massimo Morfini, Thierry Lambert, Mehdi Osooli, Silva Zupančić Šalek
Recent advancements in almost all aspects of hemophilia treatment have vastly improved patient care and management, and new and emerging treatments hold the promise of further progress. However, there remains a scarcity of data on long-term outcomes in hemophilia, particularly among those patients with inhibitors, for whom no validated outcome assessment tools are currently available. At the 15(th) Zürich Haemophilia Forum, an expert panel reviewed the most important outcome measures in inhibitor patients and considered the challenges associated with assessing outcomes in this population...
March 22, 2017: European Journal of Haematology
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