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https://www.readbyqxmd.com/read/29684921/clinical-efficacy-of-bone-reconstruction-surgery-with-frozen-cortical-bone-allografts-for-nonunion-of-radial-and-ulnar-fractures-in-toy-breed-dogs
#1
Shuntaro Munakata, Yukari Nagahiro, Daichi Katori, Norihiro Muroi, Hiroyuki Akagi, Nobuo Kanno, Yasuji Harada, Shinya Yamaguchi, Kei Hayashi, Yasushi Hara
OBJECTIVE:  To evaluate the effectiveness of frozen cortical bone allografts (FCBA) in the treatment of severe radial and ulnar atrophic nonunion fractures. ANIMALS:  Toy breed dogs with nonunion of radial and ulnar fractures ( n  = 15). METHODS:  Severe atrophic nonunion fractures were treated with FCBA (eight infected and seven non-infected fractures). Radiographs obtained immediately after surgery, and 1, 2, 3, 6 and 12 months later were evaluated and scored for the periosteal reaction at the bone regeneration sites, the healing process in the bone connection areas at both the proximal and distal sites, and the bone remodelling process within the allografts...
April 23, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29684825/exposure-to-polybrominated-diphenyl-ethers-and-phthalates-in-healthy-men-living-in-the-greater-montreal-area-a-study-of-hormonal-balance-and-semen-quality
#2
Océane Albert, Jonathan Y Huang, Katarina Aleksa, Barbara F Hales, Cynthia G Goodyer, Bernard Robaire, Jonathan Chevrier, Peter Chan
Studies investigating the associations between exposure of young men to polybrominated diphenyl ethers (PBDEs) or phthalates and hormone levels or semen quality have produced inconsistent results. Our goal was to investigate the association of exposure to PBDEs or phthalate metabolites with changes in markers of thyroid (TSH, free T3 and free T4) and reproductive function (sperm concentrations, motility, and quality; serum LH and testosterone) in 153 healthy young men from the greater Montreal area. Using covariate-adjusted models, we found that each 10-fold increase in BDE-47 was associated with lower TSH levels (-17...
April 20, 2018: Environment International
https://www.readbyqxmd.com/read/29684790/is-there-evidence-to-use-kinematic-kinetic-measures-clinically-in-low-back-pain-patients-a-systematic-review
#3
REVIEW
Enrica Papi, Anthony M J Bull, Alison H McGregor
BACKGROUND: Currently, there is a widespread reliance on self-reported questionnaires to assess low back pain patients. However, it has been suggested that objective measures of low back pain patients' functional status should be used to aid clinical assessment. The aim of this study is to systematically review which kinematic /kinetic parameters have been used to assess low back pain patients against healthy controls and to propose clinical kinematic/kinetic measures. METHODS: PubMed, Embase and Scopus databases were searched for relevant studies...
April 11, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29684742/predictors-of-basic-self-care-and-intermediate-self-care-functional-disabilities-among-older-adults-in-ghana
#4
Prince M Amegbor, Vincent Z Kuuire, Hamish Robertson, Oscar A Kuffuor
The number of older adults in Ghana is growing rapidly. Associated with this growth, is the rise in age-related chronic diseases such as cardiovascular and musculoskeletal conditions. However, there is limited knowledge in the Ghanaian context on the effect of chronic diseases on functional disabilities among older adults. In this study, we examine the association between chronic diseases, socioeconomic status, and functional disabilities. Data from 4107 Ghanaian older adults (persons aged 50 years and above) who participated in the World Health Organization's Global Ageing and Adult Health survey (SAGE-Wave 1) were used to fit random effect multivariate logistic and complementary log-log regression...
April 12, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29684645/challenges-in-pediatric-neuroimaging
#5
REVIEW
Matthew J Barkovich, Yi Li, Rahul S Desikan, A James Barkovich, Duan Xu
Pediatric neuroimaging is challenging due the rapid structural, metabolic, and functional changes that occur in the developing brain. A specially trained team is needed to produce high quality diagnostic images in children, due to their small physical size and immaturity. Patient motion, cooperation and medical condition dictate the methods and equipment used. A customized approach tailored to each child's age and functional status with the appropriate combination of dedicated staff, imaging hardware, and software is key; these range from low-tech techniques, such as feed and swaddle, to specialized small bore MRI scanners, MRI compatible incubators and neonatal head coils...
April 20, 2018: NeuroImage
https://www.readbyqxmd.com/read/29684628/inflammatory-markers-and-their-possible-effects-on-cognitive-function-in-women-with-posttraumatic-stress-disorder
#6
Risa Imai, Hiroaki Hori, Mariko Itoh, Mingming Lin, Madoka Niwa, Keiko Ino, Sei Ogawa, Makiko Ishida, Atsushi Sekiguchi, Mie Matsui, Hiroshi Kunugi, Tatsuo Akechi, Toshiko Kamo, Yoshiharu Kim
Posttraumatic stress disorder (PTSD) has been associated with increased inflammation, albeit with some controversy. Another key feature of PTSD is compromised function in wide-ranging cognitive domains. Increased peripheral inflammation can contribute to cognitive dysfunction, although this relationship has not been studied in patients with PTSD. Here, we examined blood inflammatory markers in adult patients with PTSD compared to healthy controls taking account of potentially confounding effects of childhood maltreatment and comorbid major depressive disorder (MDD), and explored the association between inflammation and cognition...
April 13, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29684504/schwann-cell-plasticity-is-regulated-by-a-weakened-intrinsic-antioxidant-defense-system-in-acute-peripheral-nerve-injury
#7
Wenjing Lv, Binbin Deng, Weisong Duan, Yuanyuan Li, Yakun Liu, Zhongyao Li, Wei Xia, Chunyan Li
The biological effects of the transcription factor NF-E2-related factor 2 (Nrf2) in acute peripheral nervous system (PNS) injury have not been adequately elucidated. By analyzing the results of Nrf2 knockout and Nrf2 activation experiments, we found the following: (1) The antioxidant system was rapidly inactivated after acute PNS injury in a partly Nrf2-dependent manner, giving rise to a temporary state of oxidative stress, and then slowly and partially recovered following regeneration. (2) Nrf2 knockout promoted the reprogramming and proliferation of Schwann cells and inhibited myelination, as well as the redifferentiation of repair Schwann cells...
April 20, 2018: Neuroscience
https://www.readbyqxmd.com/read/29684469/imaging-techniques-to-study-drug-transporter-function-in-vivo
#8
REVIEW
Nicolas Tournier, Bruno Stieger, Oliver Langer
Transporter systems involved in the permeation of drugs and solutes across biological membranes are recognized as key determinants of pharmacokinetics. Typically, the action of membrane transporters on drug exposure to tissues in living organisms is inferred from invasive procedures, which cannot be applied in humans. In recent years, imaging methods have greatly progressed in terms of instruments, synthesis of novel imaging probes as well as tools for data analysis. Imaging allows pharmacokinetic parameters in different tissues and organs to be obtained in a non-invasive or minimally invasive way...
April 20, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29684252/index-of-healthy-aging-in-chinese-older-adults-china-health-and-retirement-longitudinal-study
#9
Chenkai Wu, Anne B Newman, Bi-Rong Dong, Michelle C Odden
OBJECTIVES: To characterize the distribution of an index of healthy aging-the Chinese Healthy Aging Index (CHAI)-in Chinese adults aged 60 and older according to sociodemographic characteristics and geographic region and to examine the association between the CHAI and mortality, disability, and functional limitation over 4 years. DESIGN: Nationally representative cohort study. SETTING: China Health and Retirement Longitudinal Study. PARTICIPANTS: Chinese adults aged 60 and older (N=3,740)...
April 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29684213/low-thyroid-function-is-not-associated-with-an-accelerated-deterioration-in-renal-function
#10
Christiaan L Meuwese, Merel van Diepen, Anne R Cappola, Mark J Sarnak, Michael G Shlipak, Douglas C Bauer, Linda P Fried, Massimo Iacoviello, Bert Vaes, Jean Degryse, Kay-Tee Khaw, Robert N Luben, Bjørn O Åsvold, Trine Bjøro, Lars J Vatten, Anton J M de Craen, Stella Trompet, Giorgio Iervasi, Sabrina Molinaro, Graziano Ceresini, Luigi Ferrucci, Robin P F Dullaart, Stephan J L Bakker, J Wouter Jukema, Patricia M Kearney, David J Stott, Robin P Peeters, Oscar H Franco, Henry Völzke, John P Walsh, Alexandra Bremner, José A Sgarbi, Rui M B Maciel, Misa Imaizumi, Waka Ohishi, Friedo W Dekker, Nicolas Rodondi, Jacobijn Gussekloo, Wendy P J den Elzen
Background: Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups. Methods: Individual participant data (IPD) from 16 independent cohorts having measured thyroid stimulating hormone, free thyroxine levels and creatinine levels were included...
April 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29684199/patterns-of-ses-health-disparities-among-older-adults-in-three-upper-middle-and-two-high-income-countries
#11
Mary McEniry, Rafael Samper-Ternent, Carmen Elisa Flórez, Renata Pardo, Carlos Cano-Gutierrez
Objectives: To examine the socioeconomic status (SES) health gradient for obesity, diabetes, and hypertension within a diverse group of health outcomes and behaviors among older adults (60+) in upper middle-income countries benchmarked with high-income countries. Method : We used data from three upper middle-income settings (Colombia-SABE-Bogotá, Mexico-SAGE, and South Africa-SAGE) and two high-income countries (England-ELSA and US-HRS) to estimate logistic regression models using age, gender, and education to predict health and health behaviors...
April 19, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29684181/efficacy-and-safety-of-surgery-for-mild-degenerative-cervical-myelopathy-results-of-the-aospine-north-america-and-international-prospective-multicenter-studies
#12
Jetan H Badhiwala, Christopher D Witiw, Farshad Nassiri, Muhammad A Akbar, Alireza Mansouri, Jefferson R Wilson, Michael G Fehlings
BACKGROUND: There is controversy over the optimal treatment strategy for patients with mild degenerative cervical myelopathy (DCM). OBJECTIVE: To evaluate the degree of impairment in baseline quality of life as compared to population norms, as well as functional, disability, and quality of life outcomes following surgery in a prospective cohort of mild DCM patients undergoing surgical decompression. METHODS: We identified patients with mild DCM (modified Japanese Orthopaedic Association [mJOA] 15 to 17) enrolled in the prospective, multicenter AOSpine CSM-NA or CSM-I trials...
April 19, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29684174/grip-strength-is-associated-with-cognitive-performance-in-schizophrenia-and-the-general-population-a-uk-biobank-study-of-476559-participants
#13
Joseph Firth, Brendon Stubbs, Davy Vancampfort, Josh A Firth, Matthew Large, Simon Rosenbaum, Mats Hallgren, Philip B Ward, Jerome Sarris, Alison R Yung
Background: Handgrip strength may provide an easily-administered marker of cognitive functional status. However, further population-scale research examining relationships between grip strength and cognitive performance across multiple domains is needed. Additionally, relationships between grip strength and cognitive functioning in people with schizophrenia, who frequently experience cognitive deficits, has yet to be explored. Methods: Baseline data from the UK Biobank (2007-2010) was analyzed; including 475397 individuals from the general population, and 1162 individuals with schizophrenia...
April 19, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29684094/quantitative-analyses-of-factors-related-to-anxiety-and-depression-in-patients-with-retinitis-pigmentosa
#14
Mayumi Sainohira, Takehiro Yamashita, Hiroto Terasaki, Shozo Sonoda, Kazunori Miyata, Yusuke Murakami, Yasuhiro Ikeda, Takeshi Morimoto, Takao Endo, Takashi Fujikado, Junko Kamo, Taiji Sakamoto
The purpose of this study is to determine the factors related to anxiety and depression in patients with retinitis pigmentosa (RP). The status of anxiety and depression was determined in RP patients with the Hospital Anxiety and Depression Scale (HADS) questionnaire which consisted of subscales for HADS-anxiety (HADS-A) and HADS-depression (HADS-D). The vision-specific quality of life (VSQOL) was assessed with the National Eye Institute Visual Function Questionnaire 25 (NEI-VFQ25). The correlations between the HADS-A or HADS-D scores and vision-related clinical parameters such as the best-corrected visual acuity (BCVA), Functional Acuity Score, Functional Field Score, Functional Vision Score, the NEI- VFQ25 subscale score were determined...
2018: PloS One
https://www.readbyqxmd.com/read/29684063/do-self-reported-stress-and-depressive-symptoms-effect-endothelial-function-in-healthy-youth-the-look-longitudinal-study
#15
Lisa S Olive, Walter P Abhayaratna, Don Byrne, Alice Richardson, Richard D Telford
BACKGROUND AND AIMS: Endothelial dysfunction is thought to be an early indicator of risk for cardiovascular disease and has been associated with both stress and depression in adults and adolescents. Less is known of these relationships in younger populations, where the origins of CVD is thought to manifest. This study examined the effects of questionnaire derived psychosocial stress and depressive symptoms on endothelial function among children, following them through to adolescence. METHOD: Participants were 203 grade 2 children (111 girls; M age = 7...
2018: PloS One
https://www.readbyqxmd.com/read/29683981/chronic-liver-diseases-and-the-potential-use-of-s-adenosyl-l-methionine-as-a-hepatoprotector
#16
Silvia I Mora, Jonathan García-Román, Iván Gómez-Ñañez, Rebeca García-Román
Chronic liver diseases result in overall deterioration of health status and changes in metabolism. The search for strategies to control and combat these hepatic diseases has witnessed a great boom in the last decades. Nutritional therapy for controlling and managing liver diseases may be a positive influence as it improves the function of the liver. In this review, we focus mainly on describing liver conditions such as nonalcoholic fatty liver disease, and intrahepatic cholestasis as well as using S-adenosyl-L-methionine as a dietary supplement and its potential alternative therapeutic effect to correct the hepatic dysfunction associated with these conditions...
April 20, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29683968/functional-correlation-between-the-pancreas-and-the-small-intestine-in-humans-the-first-evaluation-using-a-newly-developed-enteroscopy
#17
Daijuro Hayashi, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Takamichi Kuwahara, Manabu Kawai, Takeshi Yamamura, Kazuhiro Furukawa, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Masatoshi Ishigami, Senju Hashimoto, Hidemi Goto
OBJECTIVES: The aim of this study is to evaluate a functional correlation between the pancreas and the small intestine and the association of this relationship with nutritional status, using magnifying enteroscopy. METHODS: The subjects were adults aged 20 years or older who underwent upper gastrointestinal endoscopy. An endoscope was inserted into the jejunum, and 10% glucose was sprayed under magnifying observation to evaluate changes in blood flow in the villous capillary network...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683887/association-of-anticholinergic-risk-score-with-functional-status-in-patients-preparing-for-pelvic-reconstructive-surgery
#18
Taylor J Brueseke, Maria de la Luz Nieto, Samantha Pulliam, Jennifer M Wu
OBJECTIVES: Anticholinergic medication use has been associated with cognitive impairment and other functional limitations, particularly in older patients. The anticholinergic risk score (ARS) can be used to measure a patient's cumulative exposure to medications with anticholinergic properties. Our primary objective was to evaluate the correlation between ARS and functional status, as measured by instrumental activities of daily living (IADL), in patients preparing to undergo urogynecologic surgery...
April 20, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29683462/polysome-profiling-in-leishmania-human-cells-and-mouse-testis
#19
Zemfira N Karamysheva, Elena B Tikhonova, Petar N Grozdanov, James C Huffman, Kristen R Baca, Alexander Karamyshev, R Brian Denison, Clinton C MacDonald, Kai Zhang, Andrey L Karamyshev
Proper protein expression at the right time and in the right amounts is the basis of normal cell function and survival in a fast-changing environment. For a long time, the gene expression studies were dominated by research on the transcriptional level. However, the steady-state levels of mRNAs do not correlate well with protein production, and the translatability of mRNAs varies greatly depending on the conditions. In some organisms, like the parasite Leishmania, the protein expression is regulated mostly at the translational level...
April 8, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29683440/an-integrated-platform-for-genome-wide-mapping-of-chromatin-states-using-high-throughput-chip-sequencing-in-tumor-tissues
#20
Christopher Terranova, Ming Tang, Elias Orouji, Mayinuer Maitituoheti, Ayush Raman, Samirkumar Amin, Zhiyi Liu, Kunal Rai
Histone modifications constitute a major component of the epigenome and play important regulatory roles in determining the transcriptional status of associated loci. In addition, the presence of specific modifications has been used to determine the position and identity non-coding functional elements such as enhancers. In recent years, chromatin immunoprecipitation followed by next generation sequencing (ChIP-seq) has become a powerful tool in determining the genome-wide profiles of individual histone modifications...
April 5, 2018: Journal of Visualized Experiments: JoVE
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