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https://www.readbyqxmd.com/read/29913423/effect-of-aminopeptidase-n-on-functions-and-fertility-of-mouse-spermatozoa-in-vitro
#1
Amena Khatun, Kyu-Ho Kang, Do-Yeal Ryu, Md Saidur Rahman, Woo-Sung Kwon, Myung-Geol Pang
Aminopeptidase N (APN) is defined as a multifunctional enzyme, which regulate cellular physiology of a wide variety of cells in human. Earlier studies reported that mammalian semen shares this common enzyme as a major protein of seminal plasma that has correlation with male fertility, while the regulatory mechanisms of APN in spermatozoa are still far from being well understood. Present study was designed to investigate the role of APN in biological and chemical functions of spermatozoa using an in vitro antagonistic approach...
June 12, 2018: Theriogenology
https://www.readbyqxmd.com/read/29913366/applying-predictive-models-to-decipher-rhizobacterial-modifications-in-common-reed-die-back-affected-populations
#2
Giovanni Bacci, Martina Cerri, Lorenzo Lastrucci, Francesco Ferranti, Valentina Ferri, Bruno Foggi, Daniela Gigante, Roberto Venanzoni, Daniele Viciani, Alessio Mengoni, Lara Reale, Andrea Coppi
The microbiota inhabiting the soil, as well as the rhizosphere, represents a key determinant of several plant functions. Like for humans, dysbiosis of the plant-associated microbiota may be a co-causal agent in disease with still obscure eziology. In the last decades, the common reed Phragmites australis has been deeply studied for its disappearance from natural stands, but no clear causative agents have been identified and no laboratory models of such "reed die-back syndrome" (RDBS) have been developed...
June 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29913232/genotoxic-alkenylbenzene-flavourings-a-contribution-to-risk-assessment
#3
Célia Martins, José Rueff, António S Rodrigues
Alkenylbenzenes, such as estragole, myristicin and eugenol, are present is several flavourings, functional foods, plant food supplements (PFS) and in complementary and alternative medicines (CAM) including herbal medicines. The increase in consumption in functional foods observed worldwide requires a strict analysis of the scientific validity of their benefits and risk-benefit ratio associated with their intake. Some instances of acute toxicity have been reported associated with the use of herbal medicines and PFS, in particular because quality control is poor, and this poses a risk especially in internet marketed products...
June 15, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29913117/biochemical-and-transcriptional-analyses-of-cadmium-induced-mitochondrial-dysfunction-and-oxidative-stress-in-human-osteoblasts
#4
Cristina Monteiro, José Miguel P Ferreira de Oliveira, Francisco Pinho, Verónica Bastos, Helena Oliveira, Francisco Peixoto, Conceição Santos
Cadmium (Cd) accumulation is known to occur predominantly in kidney and liver; however, low-level long-term exposure to Cd may also result in bone damage. Few studies have addressed Cd-induced toxicity in osteoblasts, particularly upon cell mitochondrial energy processing and putative associations with oxidative stress in bone. To assess the influence of Cd treatment on mitochondrial function and oxidative status in osteoblast cells, human MG-63 cells were treated with Cd (up to 65 μM) for 24 or 48 h. Intracellular reactive oxygen species (ROS), lipid and protein oxidation and antioxidant defense mechanisms such as total antioxidant activity (TAA) and gene expression of antioxidant enzymes were analyzed...
June 18, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29912974/early-mortality-among-children-and-adults-in-antiretroviral-therapy-programs-in-southwest-ethiopia-2003-15
#5
Hailay Abrha Gesesew, Paul Ward, Kifle Woldemichael, Lillian Mwanri
BACKGROUND: Several studies reported that the majority of deaths in HIV-infected people are documented in their early antiretroviral therapy (ART) follow-ups. Early mortality refers to death of people on ART for follow up period of below 24 months due to any cause. The current study assessed predictors of early HIV mortality in Southwest Ethiopia. METHODS: We have conducted a retrospective analysis of 5299 patient records dating from June 2003- March 2015. To estimate survival time and compare the time to event among the different groups of patients, we used a Kaplan Meir curve and log-rank test...
2018: PloS One
https://www.readbyqxmd.com/read/29912933/assessing-the-multi-scale-predictive-ability-of-ecosystem-functional-attributes-for-species-distribution-modelling
#6
Salvador Arenas-Castro, João Gonçalves, Paulo Alves, Domingo Alcaraz-Segura, João P Honrado
Global environmental changes are rapidly affecting species' distributions and habitat suitability worldwide, requiring a continuous update of biodiversity status to support effective decisions on conservation policy and management. In this regard, satellite-derived Ecosystem Functional Attributes (EFAs) offer a more integrative and quicker evaluation of ecosystem responses to environmental drivers and changes than climate and structural or compositional landscape attributes. Thus, EFAs may hold advantages as predictors in Species Distribution Models (SDMs) and for implementing multi-scale species monitoring programs...
2018: PloS One
https://www.readbyqxmd.com/read/29912924/hemodiafiltration-is-associated-with-reduced-inflammation-oxidative-stress-and-improved-endothelial-risk-profile-compared-to-high-flux-hemodialysis-in-children
#7
Ayşe Ağbaş, Nur Canpolat, Salim Çalışkan, Alev Yılmaz, Hakan Ekmekçi, Mark Mayes, Helen Aitkenhead, Franz Schaefer, Lale Sever, Rukshana Shroff
Randomized trials in adults have shown reduced all-cause and cardiovascular mortality on hemodiafiltration (HDF) compared to high-flux hemodialysis (HD), but the mechanisms leading to improved outcomes are not clear. We studied biomarkers of inflammation, oxidative stress, anti-oxidant capacity and endothelial dysfunction in 22 children (13 female, age 8-15 years). All children received HD for at least 3 months, and were then switched to HDF, keeping all dialysis related parameters and dialysis time constant...
2018: PloS One
https://www.readbyqxmd.com/read/29912730/predictors-and-long-term-outcome-of-sexual-function-after-surgical-treatment-for-single-level-lumbar-disk-herniation-among-patients-in-a-german-spine-center
#8
Alaa E Elsharkawy, Bettina Lange, Fernando Caldas, Abdel H Alabbasi, Peter D Klassen
STUDY DESIGN: This is a retrospective, self-controlled cohort study, at a single center. OBJECTIVE: The aim of this study was to evaluate the long-term outcome of sexual function after surgical treatment of single-level lumbar disk herniation (LDH). SUMMARY OF BACKGROUND DATA: The impact of surgical treatment on sexual activity is still unknown and not well researched. MATERIALS AND METHODS: In total, 114 patients who underwent disk surgery for LDH between 2009 and 2015 were included in the study (mean age, 46...
June 15, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29912601/preliminary-efficacy-of-a-friendly-constraint-induced-therapy-friendly-cit-program-on-motor-and-psychosocial-outcomes-in-children-with-cerebral-palsy
#9
Yu-Lun Chen, Hao-Ling Chen, Jeng-Yi Shieh, Tien-Ni Wang
AIMS: Constraint-induced therapy (CIT) is effective, but concerns have been repeatedly raised regarding the generalizability, feasibility, and potentially intrusive nature of restraining a child's unimpaired upper limb. We examined the feasibility and efficacy of friendly-CIT, which uses home-based model, a caregiver-determined schedule, and gentle restraint, in children with cerebral palsy. METHODS: In a one-group pre-post intervention trial, 15 children (median of age = 8 years, 4 months) participated in 8 weeks of friendly-CIT (36 hours)...
June 18, 2018: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/29912572/perfluorocarbon-liquid-vs-subretinal-fluid-drainage-during-vitrectomy-for-the-primary-repair-of-rhegmatogenous-retinal-detachment-a-comparative-study
#10
Orit Vidne, Sharon Blum Meirovitch, Gilad Rabina, Amir Abd Eelkader, Daphna Prat, Dana Barequet, Joseph Moisseiev, Elad Moisseiev
PURPOSE: To compare the anatomical and functional results achieved with subretinal fluid drainage (SRFD) and perfluorocarbon liquid (PFCL) use in patients with rhegmatogenous retinal detachment (RRD) treated by primary pars plana vitrectomy (PPV). METHODS: The study included 162 eyes of 162 patients who underwent PPV for RRD, either with PFCL (n = 108) or SRFD (n = 54). The 2 groups were matched in 2:1 ratio for age, gender and lens status. Groups were compared for rates of retinal reattachment, visual improvement, and the occurrence of recurrent RRD and any other postoperative complications...
June 18, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29912568/changes-in-muscle-thickness-across-positions-on-ultrasound-imaging-in-participants-with-or-without-a-history-of-low-back-pain
#11
Mark Sutherlin, Matthew Gage, Colby Mangum, Jay Hertel, Shawn Russell, Susan A Saliba, Joseph M Hart
CONTEXT:   Injury-prediction models have identified trunk muscle function as an identifiable factor for future injury. A history of low back pain (HxLBP) may also place athletes at increased risk for future low back pain. Reduced muscle thickness of the lumbar multifidus (LM) and transversus abdominis (TrA) has been reported among populations with clinical low back pain via ultrasound imaging in multiple positions. However, the roles of the LM and TrA in a more functional cohort and for injury prediction are still unknown...
June 18, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29912321/genome-wide-studies-of-heart-failure-and-endophenotypes-lessons-learned-and-future-directions
#12
M Yldau van der Ende, M Abdullah Said, Dirk J van Veldhuisen, N Verweij, Pim van der Harst
Heart failure (HF) is a complex clinical syndrome resulting from structural or functional impairments of ventricular filling or ejection of blood. HF has a poor prognosis and the burden to society remains tremendous. The unfulfilled expectation is that expanding our knowledge of the genetic architecture of HF will help to quickly advance the quality of risk assessment, diagnoses, and treatment. To date, Genome Wide Association Studies (GWAS) of HF have led to disappointing results with only limited progress in our understanding and tempering the earlier expectations...
April 18, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29912152/susceptibility-to-alcohol-hangovers-the-association-with-self-reported-immune-status
#13
Aurora J A E van de Loo, Marlou Mackus, Marith van Schrojenstein Lantman, Aletta D Kraneveld, Karel A Brookhuis, Johan Garssen, Andrew Scholey, Joris C Verster
Increasing evidence points at a role for the immune system in the genesis of the alcohol hangover. This study investigated the association between self-reported immune function and experiencing hangovers. Dutch students aged 18 to 30 years old were invited to complete an online survey. Eighteen items on immune-related complaints were completed to assess self-reported immune function. Alcohol consumption in the past month (with respect to usual consumption and the occasion of heaviest drinking) was also recorded...
June 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29912004/clinical-and-molecular-recursive-partitioning-analysis-of-high-grade-glioma-treated-with-imrt
#14
Philip Sutera, Ronny Kalash, John Flickinger, Johnathan Engh, Dwight E Heron
INTRODUCTION: Despite multimodal treatment for high-grade gliomas, prognosis remains grim. Prior Radiation Therapy Oncology Group-Recursive Partitioning Analysis (RTOG-RPA) reports indicate based on pretreatment and treatment-related factors, a subset of patients experience a significantly improved survival. Since the development of the RTOG-RPA, high-grade gliomas have seen the widespread introduction of temozolomide and tumor oncogenetics. Here we aimed to determine whether the RTOG-RPA retained prognostic significance in the context of modern treatment, as well as generate an updated RPA incorporating both clinical and genetic variables...
June 14, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29911853/3d-printed-wearable-sensors-with-liquid-metals-for-the-pose-detection-of-snakelike-soft-robots
#15
Luyu Zhou, Qing Gao, Jun-Fu Zhan, Chao-Qi Xie, Jianzhong Fu, Yong He
Liquid metal-based flexible sensors, which utilize advanced liquid conductive material to serve as sensitive element, is emerging as a promising solution to measure large deformations. Nowadays, one of the biggest challenges for precise control of soft robots is the detection of their real time positions. Existing fabrication methods are unable to fabricate flexible sensors that match the shape of soft robots. In this report, we firstly described a novel 3D printed multi-function inductance flexible and stretchable sensor with liquid metals (LMs), which is capable of measuring both axial tension and curvature...
June 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29911470/endothelial-cells-are-critical-regulators-of-iron-transport-in-a-model-of-the-human-blood-brain-barrier
#16
Brian Chiou, Emma H Neal, Aaron B Bowman, Ethan S Lippmann, Ian A Simpson, James R Connor
Iron delivery to the brain is essential for multiple neurological processes such as myelination, neurotransmitter synthesis, and energy production. Loss of brain iron homeostasis is a significant factor in multiple neurological disorders. Understanding the mechanism by which the transport of iron across the blood-brain barrier (BBB) is regulated is crucial to address the impact of iron deficiency on brain development and excessive accumulation of iron in neurodegenerative diseases. Using induced pluripotent stem cell (iPSC)-derived brain endothelial cells (huECs) as a human BBB model, we demonstrate the ability of transferrin, hepcidin, and DMT1 to impact iron transport and release...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29911068/assessment-of-oral-health-related-quality-of-life-for-complex-mandibular-defects-rehabilitated-with-computer-guided-implant-restoration
#17
Parithimar Kalaignan, Jaya Shree Mohan, Arun Jayakumar
The individuals who have been afflicted with mandibular defects involving soft and hard tissue loss are subjected to functional, psychological and social consequences. Rehabilitation is of prime importance in restoring self confidence and improving the quality of life. Complex mandibular defects can be successfully rehabilitated with the three dimensional (3D) computerized diagnostic technique (Simplant-Dentsply sirona implant). one of the important tools for measuring the oral health status by scale knows as oral health impact profile (OHIP)...
May 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29911040/duration-of-casual-sunlight-exposure-necessary-for-adequate-vitamin-d-status-in-indian-men
#18
Vivek G Patwardhan, Zulf M Mughal, Shashi A Chiplonkar, Ann R Webb, Richard Kift, Vaman V Khadilkar, Raja Padidela, Anuradha V Khadilkar
Objectives: To investigate the duration of casual sunlight ultraviolet-B (UVB) exposure required to maintain optimal Vitamin D status (25-hydroxyvitamin-D [25(OH)D]) >50 nmol/L in urban Indian men, using polysulfone (PSU) dosimeters and a sunlight exposure questionnaire. Methods: In healthy men (aged 40-60 years) from Pune (18.52° N, 73.86° E), India, serum 25(OH)D was measured using enzyme-linked immunosorbent assay. Sunlight exposure was assessed using PSU dosimeter and by questionnaire...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29910810/adaptive-regulation-of-osteopontin-production-by-dendritic-cells-through-the-bidirectional-interaction-with-mesenchymal-stromal-cells
#19
Sara Scutera, Valentina Salvi, Luisa Lorenzi, Giorgia Piersigilli, Silvia Lonardi, Daniela Alotto, Stefania Casarin, Carlotta Castagnoli, Erica Dander, Giovanna D'Amico, Silvano Sozzani, Tiziana Musso
Mesenchymal stromal cells (MSCs) exert immunosuppressive effects on immune cells including dendritic cells (DCs). However, many details of the bidirectional interaction of MSCs with DCs are still unsolved and information on key molecules by which DCs can modulate MSC functions is limited. Here, we report that osteopontin (OPN), a cytokine involved in homeostatic and pathophysiologic responses, is constitutively expressed by DCs and regulated in the DC/MSC cocultures depending on the activation state of MSCs...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29910637/combined-microwave-ablation-and-minimally-invasive-open-decompression-for-the-management-of-thoracic-metastasis-in-breast-cancer
#20
Bin Liu, Zhenchao Yuan, Chang Yuan Wei
Objective: The incidence rate of thoracic metastasis from breast cancer is increasing. Microwave ablation is one type of clinical therapy used to treat metastatic spine disease, although it can cause protein denaturation and immediate cell death, and coagulative necrosis can occur. Minimally invasive open decompression is associated with lower rates of surgical complications in comparison to traditional open surgery. Therefore, it is an alternative therapeutic option for spinal metastases...
2018: Cancer Management and Research
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