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https://www.readbyqxmd.com/read/28830024/cognitive-remediation-training-improves-performance-in-patients-with-chronic-fatigue-syndrome
#1
Richard L McBride, Sarah Horsfield, Carolina X Sandler, Joanne Cassar, Sally Casson, Erin Cvejic, Uté Vollmer-Conna, Andrew R Lloyd
Neurocognitive disturbance with subjectively-impaired concentration and memory is a common, disabling symptom reported by patients with chronic fatigue syndrome (CFS). We recently reported preliminary evidence for benefits of cognitive remediation as part of an integrated cognitive-behavioral therapy (CBT)/ graded exercise therapy (GET) program. Here, we describe a contemporaneous, case-control trial evaluating the effectiveness of an online cognitive remediation training program (cognitive exercise therapy; CET) in addition to CBT/GET (n=36), compared to CBT/GET alone (n=36)...
August 18, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28829667/construct-validity-of-the-functional-assessment-of-verbal-reasoning-and-executive-strategies-favres
#2
Christopher I Higginson, Tom Thompson, Abigail E Benjamin, Allison C Rosales, Katherine L Zane, Marisa Valenti, Karlie Ibrahim, Megan A Rock, Trisha A Chaffee
BACKGROUND: The Functional Assessment of Verbal Reasoning and Executive Strategies (FAVRES) is a measure of cognitive-communication and executive functions involving everyday tasks. Scores are predictive of employment status; however, the measure's construct validity is unclear. OBJECTIVE: The study's objective was to assess the linear association of FAVRES test performance with performance on a number of neuropsychological measures in a sample of individuals with neurocognitive deficits...
August 22, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28829493/effects-of-il-10-on-iron-metabolism-in-lps-induced-inflammatory-mice-via-modulating-hepcidin-expression
#3
P Huang, J Wang, X Lin, F-F Yang, J-H Tan
OBJECTIVE: Body's iron metabolism is at one dynamic balance status, and abnormal iron metabolism may lead to renal anemia. Inflammation stimuli may lead to abnormal iron metabolism and aggravation of chronic failure anemia. Hepcidin can regulate iron metabolic homeostasis, further mediating renal anemia. Interleukin-10 (IL-10) is an inflammatory inhibitor, but with an unclear function in the regulation of hepcidin expression. MATERIALS AND METHODS: BALB/c mice were randomly assigned into three groups: control group; lipid polysaccharide (LPS) group, which received 0...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28829221/enhanced-recovery-after-surgery-in-laparoscopic-surgery
#4
Kay B Leissner, Jessica L Shanahan, Peter L Bekker, Houman Amirfarzan
BACKGROUND: As part of an effort to maximize value in the perioperative setting, a paradigm shift is underway in the way that patients are cared for preoperatively, on the day of surgery, and postoperatively-a setting collectively known as the perioperative care. Enhanced Recovery After Surgery (ERAS(®)) is an evidence-based, patient-centered team approach to delivering high-quality perioperative care to surgical patients. METHODS: This review focuses on anesthesiologists, with their unique purview of perioperative setting, who are important drivers of change in the delivery of valuable perioperative care...
August 22, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28828747/patient-reported-outcomes-correlate-with-functional-scores-after-opening-wedge-high-tibial-osteotomy-a-clinical-study
#5
Seung-Beom Han, Jong-Hee Lee, Seul-Gi Kim, Chun-Guang Cui, Dong-Won Suh, Seung-Yup Lee, Ki-Mo Jang
PURPOSE: The purpose of this study was to assess post-operative patient subjective satisfaction and to analyze associated peri-operative factors following biplanar medial open wedge high tibial osteotomy (OWHTO). METHODS: The study cohort consisted of 88 patients with a minimum of two years of follow-up. Patient satisfaction was evaluated with a questionnaire that assessed (1) overall satisfaction, (2) pain relief, (3) daily living functions, and (4) cosmesis. Patients were categorized into two groups (satisfied or unsatisfied) based on overall satisfaction questionnaire...
August 21, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28828628/different-substrate-regimes-determine-transcriptional-profiles-and-gene-co-expression-in-methanosarcina-barkeri-dsm-800
#6
Qiang Lin, Xiaoyu Fang, Adrian Ho, Jiaying Li, Xuefeng Yan, Bo Tu, Chaonan Li, Jiabao Li, Minjie Yao, Xiangzhen Li
Methanosarcina barkeri (DSM 800) is a metabolically versatile methanogen and shows distinct metabolic status under different substrate regimes. However, the mechanisms underlying distinct transcriptional profiles under different substrate regimes remain elusive. In this study, based on transcriptional analysis, the growth performances and gene expressions of M. barkeri fed on acetate, H2 + CO2, and methanol, respectively, were investigated. M. barkeri showed higher growth performances under methanol, followed by H2 + CO2 and acetate, which corresponded well with the variations of gene expressions...
August 21, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28828576/bone-turnover-is-altered-in-transgenic-rats-overexpressing-the-p2y2-purinergic-receptor
#7
Maria Ellegaard, Cansu Agca, Solveig Petersen, Ankita Agrawal, Lars Schack Kruse, Ning Wang, Alison Gartland, Jens-Erik Beck Jensen, Niklas Rye Jørgensen, Yuksel Agca
It is now widely recognized that purinergic signaling plays an important role in the regulation of bone remodeling. One receptor subtype, which has been suggested to be involved in this regulation, is the P2Y2 receptor (P2Y2R). In the present study, we investigated the effect of P2Y2R overexpression on bone status and bone cell function using a transgenic rat. Three-month-old female transgenic Sprague Dawley rats overexpressing P2Y2R (P2Y2R-Tg) showed higher bone strength of the femoral neck. Histomorphometry showed increase in resorptive surfaces and reduction in mineralizing surfaces...
August 21, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28828568/development-and-psychometric-evaluation-of-the-promis-pediatric-life-satisfaction-item-banks-child-report-and-parent-proxy-editions
#8
Christopher B Forrest, Janine Devine, Katherine B Bevans, Brandon D Becker, Adam C Carle, Rachel E Teneralli, JeanHee Moon, Carole A Tucker, Ulrike Ravens-Sieberer
PURPOSE: To describe the psychometric evaluation and item response theory calibration of the PROMIS Pediatric Life Satisfaction item banks, child-report, and parent-proxy editions. METHODS: A pool of 55 life satisfaction items was administered to 1992 children 8-17 years old and 964 parents of children 5-17 years old. Analyses included descriptive statistics, reliability, factor analysis, differential item functioning, and assessment of construct validity. Thirteen items were deleted because of poor psychometric performance...
August 21, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28828310/role-of-accreditation-in-quality-improvement-of-institutional-review-board
#9
Abhidnya Vasant Desai, Rohini W Hawaldar, Jigeeshu V Divatia
AIM: The aim of this study was to evaluate the process of accreditation resulting in improvement of the Institutional Review Board (IRB) functioning. METHODOLOGY: Randomly selected projects from years 2007 (before accreditation), 2010 (after accreditation), and 2013 (after reaccreditation) were evaluated to assess parameters, namely, submission of good clinical practices (GCPs), completeness of IRB submission form, fulfillment of quorum, documentation of the declaration of conflict of interests, and submission of the status reports...
July 2017: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/28828277/diversity-of-compounds-in-femoral-secretions-of-gal%C3%A3-pagos-iguanas-genera-amblyrhynchus-and-conolophus-and-their-potential-role-in-sexual-communication-in-lek-mating-marine-iguanas-amblyrhynchus-cristatus
#10
Alejandro Ibáñez, Markus Menke, Galo Quezada, Gustavo Jiménez-Uzcátegui, Stefan Schulz, Sebastian Steinfartz
BACKGROUND: Chemical signals are widely used in the animal kingdom, enabling communication in various social contexts, including mate selection and the establishment of dominance. Femoral glands, which produce and release waxy secretions into the environment, are organs of central importance in lizard chemical communication. The Galápagos marine iguana (Amblyrhynchus cristatus) is a squamate reptile with a lek-mating system. Although the lekking behaviour of marine iguanas has been well-studied, their potential for sexual communication via chemical cues has not yet been investigated...
2017: PeerJ
https://www.readbyqxmd.com/read/28828053/ultrasound-prenatal-diagnosis-and-emergency-interventional-radiologic-therapy-of-galen-aneurysmal-malformation-in-a-newborn
#11
Roxana Elena Bohiltea, Natalia Turcan, Cristian Mihalea, Bogdan Dorobat, Eliza Elena Cinteza, Adriana Dan, Magdalena Mihai, Adela Dimitriade, Cristian Boros, Mircea Dumitru, Ionut Gobej, Octavian Munteanu, Monica Mihaela Cirstoiu
Located under the cerebral hemispheres and draining the anterior and central regions of the brain into the sinus of the posterior cerebral fossa, the vein of Galen aneurysmal malformation is considered to be a rare cause of hydrocephaly. The presence of this condition in the neonatal period typically includes intractable heart failure and a poor prognosis. We report a case of aneurysm of the vein of Galen diagnosed prenatally at 28 weeks of gestation, with the delivery at term by caesarean section of a female infant...
December 2016: Mædica
https://www.readbyqxmd.com/read/28828035/urine-flow-rate-monitoring-in-hypovolemic-multiple-trauma-patients
#12
Evgeni Brotfain, Yoram Klein, Ronen Toledano, Leonid Koyfman, Dmitry Frank, Micha Y Shamir, Moti Klein
BACKGROUND: The urine output is an important clinical parameter of renal function and blood volume status, especially in critically ill multiple trauma patients. In the present study, the minute-to-minute urine flow rate and its variability were analyzed in hypotensive multiple trauma patients during the first 6 h of their ICU (intensive care unit) stay. These parameters have not been previously reported. METHODS: The study was retrospective and observational. Demographic and clinical data were extracted from the computerized Register Information Systems...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28827934/the-process-of-translation-and-linguistic-validation-of-the-functional-assessment-of-cancer-therapy-brain-quality-of-life-instrument-from-english-to-malayalam-the-challenges-faced
#13
Durgapoorna Menon, Chitra Venkateswaran
AIM: Both brain tumors and their treatments have a major negative impact on the quality of life (QoL). EORTC BN20 and Functional Assessment of Cancer Therapy-Brain (FACT-BR) are the most commonly used tools to assess QoL. The FACT-BR is a 23-item questionnaire, especially about the psychosocial aspects of QoL. This paper describes the challenges we faced during the process of translation and validation of the FACT-BR into Malayalam. METHODS: We first screened the patients to ensure their mental status was satisfactory and that they could communicate well in both languages...
July 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/28827930/fluoroscopy-guided-neurolytic-splanchnic-nerve-block-for-intractable-pain-from-upper-abdominal-malignancies-in-patients-with-distorted-celiac-axis-anatomy-an-effective-alternative-to-celiac-plexus-neurolysis-a-retrospective-study
#14
Arif Ahmed, Divesh Arora
INTRODUCTION: The pain from upper gastrointestinal malignancy leads to considerable morbidity. The celiac plexus and splanchnic nerve neurolysis are good therapeutic options. Although splanchnic nerve neurolysis less frequently performed, but it has an edge over celiac plexus as it can be performed in patients with altered celiac plexus anatomy by enlarged lymph nodes. METHODS: The fluoroscopy-guided splanchnic nerve neurolysis was done in about 21 patients with intractable upper abdominal pain with pain intensity of ≥7 in numerical rating scale (NRS) from upper gastrointestinal cancers with distorted celiac plexus anatomy from enlarged celiac lymph nodes as seen by computed tomography scan after positive diagnostic splanchnic nerve neurolysis...
July 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/28827770/quality-of-non-expert-citizen-science-data-collected-for-habitat-type-conservation-status-assessment-in-natura-2000-protected-areas
#15
A S Kallimanis, M Panitsa, P Dimopoulos
EU biodiversity conservation policy is based on the Habitats Directive (92/43/EC), which aims that habitat types and species of Community interest should reach 'favourable conservation status'. To this end, Member States are obliged to perform periodic assessment of species and habitat conservation status through biodiversity monitoring, which, in almost all cases, was performed by experts implementing standardized field protocols. Here, we examine the quality of data collected in the field by non-experts (citizen scientists) for the conservation status assessment of habitat types, and specifically for the criteria 'typical species', 'specific structures and functions', and 'pressures and threats'...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827456/thioredoxin-and-nadph-dependent-thioredoxin-reductase-c-regulation-of-tetrapyrrole-biosynthesis
#16
Qingen Da, Peng Wang, Menglong Wang, Ting Sun, Honglei Jin, Bing Liu, Jinfa Wang, Bernhard Grimm, Hong-Bin Wang
In chloroplasts, thioredoxin (TRX) isoforms and NADPH-dependent thioredoxin reductase C (NTRC) act as redox regulatory factors involved in multiple plastid biogenesis and metabolic processes. To date, less is known about the functional coordination between TRXs and NTRC in chlorophyll (Chl) biosynthesis. In this study, we aimed to explore the potentially functions of TRX m and NTRC in the regulation of the tetrapyrrole biosynthesis (TBS) pathway. Silencing of three genes, TRX m1, TRX m2, and TRX m4 (TRX ms), led to pale-green leaves, a significantly reduced 5-aminolevulinic acid (ALA)-synthesizing capacity, and reduced accumulation of Chl and its metabolic intermediates in Arabidopsis thaliana...
August 21, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28827279/leaving-the-labour-market-later-in-life-how-does-it-impact-on-mechanisms-for-health
#17
Elise Whitley, Frank Popham
OBJECTIVES: Negative associations between non-employment and health among older people are well established and are potentially important for successful ageing. However, opportunities to improve health through re-employment or extending working lives are limited as later-life exits from employment are often unwanted and permanent. We aim to establish a greater understanding of the psychosocial mechanisms underlying non-employment and health associations in older people to identify modifiable pathways through which the negative impact of non-employment can be ameliorated...
August 21, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28827086/risk-factors-for-erectile-dysfunction-in-men-with-htlv-1
#18
Cassius José Vitor de Oliveira, José Abraão Carneiro Neto, Rosana C P Andrade, Paulo Novis Rocha, Edgar Marcelino de Carvalho Filho
BACKGROUND: Erectile dysfunction (ED) occurs in more than 50% of patients with human T-cell lymphotropic virus type 1 (HTLV-1) infection. In the general population, atherosclerosis is the main risk factor related to ED. AIM: To compare the contribution of neurologic disorders from HTLV-1 with that of atherosclerosis as risk factors for ED in men with HTLV-1. METHODS: In this cross-sectional study, men 18 to 70 years old with HTLV-1 were classified into one of two groups according to the presence or absence of ED...
August 18, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28826908/-comparison-of-predictive-models-for-the-selection-of-high-complexity-patients
#19
Marcos Estupiñán-Ramírez, Rita Tristancho-Ajamil, María Consuelo Company-Sancho, Hilda Sánchez-Janáriz
OBJECTIVE: To compare the concordance of complexity weights between Clinical Risk Groups (CRG) and Adjusted Morbidity Groups (AMG). To determine which one is the best predictor of patient admission. To optimise the method used to select the 0.5% of patients of higher complexity that will be included in an intervention protocol. METHOD: Cross-sectional analytical study in 18 Canary Island health areas, 385,049 citizens were enrolled, using sociodemographic variables from health cards; diagnoses and use of healthcare resources obtained from primary health care electronic records (PCHR) and the basic minimum set of hospital data; the functional status recorded in the PCHR, and the drugs prescribed through the electronic prescription system...
August 18, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28826906/aluminum-exposure-at-human-dietary-levels-promotes-vascular-dysfunction-and-increases-blood-pressure-in-rats-a-concerted-action-of-nad-p-h-oxidase-and-cox-2
#20
Caroline Silveira Martinez, Janaina Trindade Piagette, Alyne Gourlart Escobar, Ángela Martín, Roberto Palacios, Franck Maciel Peçanha, Dalton Valentim Vassallo, Christopher Exley, María Jesús Alonso, Marta Miguel, Mercedes Salaices, Giulia Alessandra Wiggers
Aluminum (Al) is a non-essential metal and a significant environmental contaminant and is associated with a number of human diseases including cardiovascular disease. We investigated the effects of Al exposure at doses similar to human dietary levels on the cardiovascular system over a 60day period. Wistar male rats were divided into two major groups and received orally: 1) Low aluminum level - rats were subdivided and treated for 60days as follows: a) Untreated - ultrapure water; b) AlCl3 at a dose of 8.3mg/kg bw for 60 days, representing human Al exposure by diet; and 2) High aluminum level - rats were subdivided and treated for 42days as follows: C) Untreated - ultrapure water; d) AlCl3 at 100mg/kg bw for 42 days, representing a high level of human exposure to Al...
August 18, 2017: Toxicology
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