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obesity and disability

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https://www.readbyqxmd.com/read/28808579/a-novel-bbs10-mutation-identified-in-a-patient-with-bardet-biedl-syndrome-with-a-violent-emotional-outbreak
#1
Tatsuyuki Ohto, Takashi Enokizono, Ryuta Tanaka, Mai Tanaka, Hisato Suzuki, Aiko Sakai, Kazuo Imagawa, Hiroko Fukushima, Takashi Fukushima, Ryo Sumazaki, Tomoko Uehara, Toshiki Takenouchi, Kenjiro Kosaki
We report a 10-year-old girl with Bardet-Biedl syndrome caused by a novel mutation in the Bardet-Biedl syndrome 10 (BBS10) gene. She had multiple malformations, including a dysmorphic face, postaxial polydactyly, polycystic kidney and amblyopia. She presented with typical BBS features, including intellectual disability with emotional outbursts and mild obesity. Whole-exome sequencing identified compound heterozygous mutations with NM_024685.3:c.1677C>A [p.(Tyr559*)] and c.1974T>G [p.(Tyr658*)]. To our knowledge, the latter mutation has never been reported previously...
2017: Human Genome Variation
https://www.readbyqxmd.com/read/28807816/mtor-in-down-syndrome-role-in-a%C3%A3-and-tau-neuropathology-and-transition-to-alzheimer-disease-like-dementia
#2
REVIEW
Fabio Di Domenico, Antonella Tramutola, Cesira Foppoli, Elisabeth Head, Marzia Perluigi, D Allan Butterfield
The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase involved in the regulation of protein synthesis and degradation, longevity and cytoskeletal formation. The mTOR pathway represents a key growth and survival pathway involved in several diseases such as cancer, obesity, cardiovascular disease and neurodegenerative diseases. Numerous studies linked the alterations of mTOR pathway to age-dependent cognitive decline, pathogenesis of Alzheimer disease (AD) and AD-like dementia in Down syndrome (DS)...
August 11, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28803172/influence-of-obesity-on-complications-clinical-outcome-and-subsidence-following-anterior-lumbar-interbody-fusion-alif-prospective-observational-study
#3
Kevin Phan, Priya Rogers, Prashanth J Rao, Ralph J Mobbs
BACKGROUND: The complications associated with obesity have been well described for posterior lumbar spinal surgery. However, the influence of obesity on anterior lumbar interbody fusion (ALIF) is not well established. We aimed to compare complication risks, functional outcomes and subsidence rates in normal, overweight and obese patients who underwent ALIF. METHODS: 137 consecutive patients undergoing ALIF surgery from 2012-2014 were prospectively followed. Patients were categorized into 3 groups according to their body mass index (BMI)...
August 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28802895/physical-activity-and-obesity-among-nine-year-old-children-with-and-without-chronic-health-problems-illness-or-disabilities-in-ireland
#4
Justin A Haegele, Sean Healy, Xihe Zhu
BACKGROUND: Regular engagement in physical activity can help youth control their weight during childhood while decreasing one's chances of developing chronic diseases (e.g., coronary heart disease, diabetes) throughout the lifespan. While numerous studies have explored physical activity participation and weight status among typically developing children, few epidemiological studies utilizing nationally representative data has focused on children with chronic health problems, illness, or disabilities (CHID)...
August 8, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28776243/burden-of-obesity-in-the-eastern-mediterranean-region-findings-from-the-global-burden-of-disease-2015-study
#5
Ali H Mokdad
OBJECTIVES: We used the Global Burden of Disease (GBD) 2015 study results to explore the burden of high body mass index (BMI) in the Eastern Mediterranean Region (EMR). METHODS: We estimated the prevalence of overweight and obesity among children (2-19 years) and adults (≥20 years) in 1980 and 2015. The burden of disease related to high BMI was calculated using the GBD comparative risk assessment approach. RESULTS: The prevalence of obesity increased for adults from 15...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28775179/health-and-economic-benefits-of-reducing-sugar-intake-in-the-usa-including-effects-via-non-alcoholic-fatty-liver-disease-a-microsimulation-model
#6
Rick A Vreman, Alex J Goodell, Luis A Rodriguez, Travis C Porco, Robert H Lustig, James G Kahn
OBJECTIVES: Excessive consumption of added sugars in the human diet has been associated with obesity, type 2 diabetes (T2D), coronary heart disease (CHD) and other elements of the metabolic syndrome. Recent studies have shown that non-alcoholic fatty liver disease (NAFLD) is a critical pathway to metabolic syndrome. This model assesses the health and economic benefits of interventions aimed at reducing intake of added sugars. METHODS: Using data from US National Health Surveys and current literature, we simulated an open cohort, for the period 2015-2035...
August 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28754212/health-promotion-research-in-active-duty-army-soldiers-the-road-to-a-fit-and-ready-force
#7
Mary S McCarthy, Evelyn B Elshaw, Barbara M Szekely, Bethann Pflugeisen
BACKGROUND: In the last decade the Military Health System has changed its paradigm to focus on health promotion and disease prevention. PURPOSE: This paper reviews a decade of research exploring the effects of military life on nutritional status and bone health of Army soldiers. METHOD: Descriptive and experimental approaches have assessed occupational demands on soldiers in variable environments that require optimal nutrition status and physical health...
July 5, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28750547/addressing-medical-needs-of-adolescents-and-adults-with-autism-spectrum-disorders-in-a-primary-care-setting
#8
Youssra Saqr, Erika Braun, Kyle Porter, Debra Barnette, Christopher Hanks
Little has been reported about how to improve health care access and delivery for adolescents and adults with autism spectrum disorder. To understand the contributions to the health disparities in the autism spectrum disorder population, we conducted two independent research approaches to learn about current medical needs. A retrospective chart review was performed to evaluate medical comorbidities and medication use. A focus group was also created to address barriers faced in providing medical care. Of 126 charts reviewed, 49% (n = 62) had intellectual disability, 49% (n = 62) had attention-deficit hyperactivity disorder, 52% (n = 65) had anxiety, 41% (n = 52) had obesity, 31% (n = 39) with a history of aggressive behavior, 31% (n = 31) had depression, 22% (n = 28) had seizures, and 9% (n = 11) had hypertension...
July 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28744225/is-it-time-to-begin-a-public-campaign-concerning-frailty-and-pre-frailty-a-review-article
#9
REVIEW
Jerzy Sacha, Magdalena Sacha, Jacek Soboń, Zbigniew Borysiuk, Piotr Feusette
Frailty is a state that encompasses losses in physical, psychological or social domains. Therefore, frail people demonstrate a reduced potential to manage external stressors and to respond to life incidents. Consequently, such persons are prone to various adverse consequences such as falls, cognitive decline, infections, hospitalization, disability, institutionalization, and death. Pre-frailty is a condition predisposing and usually preceding the frailty state. Early detection of frailty (i.e., pre-frailty) may present an opportunity to introduce effective management to improve outcomes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28738796/health-profile-for-danish-adults-with-activity-limitation-a-cross-sectional-study
#10
Nina Føns Johnsen, Michael Davidsen, Susan Ishøy Michelsen, Knud Juel
BACKGROUND: Studies have indicated that people with disabilities die earlier and may experience a poorer health than the general population. This study investigated 31 factors related to health and well-being, health behaviour and social relations among Danish adults with activity limitation (AL). METHODS: This study was based on data from the Danish Health and Morbidity Survey (DHMS) 2013 where 25,000 men and women aged 16 years or older were selected randomly from the adult Danish population...
July 24, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28735833/cannabis-use-in-people-with-parkinson-s-disease-and-multiple-sclerosis-a-web-based-investigation
#11
John H Kindred, Kaigang Li, Nathaniel B Ketelhut, Felix Proessl, Brett W Fling, Justin M Honce, William R Shaffer, Thorsten Rudroff
OBJECTIVES: Cannabis has been used for medicinal purpose for thousands of years; however the positive and negative effects of cannabis use in Parkinson's disease (PD) and Multiple Sclerosis (MS) are mostly unknown. Our aim was to assess cannabis use in PD and MS and compare results of self-reported assessments of neurological disability between current cannabis users and non-users. METHODS: An anonymous web-based survey was hosted on the Michael J. Fox Foundation and the National Multiple Sclerosis Society webpages from 15 February to 15 October 2016...
August 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28731608/dietetic-and-educational-interventions-improve-clinical-outcomes-of-diabetic-and-obese-clients-with-mental-impairment
#12
Kerri Hunt, Kathy Stiller
AIM: The aim of this study was to evaluate the effect of dietetic and educational interventions provided to clients with type 2 diabetes (with or without obesity) or obesity-only residing in supported residential facilities and characterised by mental impairment. METHODS: A retrospective audit involving the retrieval of information from medical records and databases was undertaken to evaluate the effect of dietetic and educational interventions. Clinical outcomes were weight, body mass index and glycosylated haemoglobin (HbA1c) levels...
July 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28724530/the-population-health-benefits-of-a-healthy-lifestyle-life-expectancy-increased-and-onset-of-disability-delayed
#13
Neil Mehta, Mikko Myrskylä
A key determinant of population health is the behavioral profile of a population. Nearly 80 percent of Americans reach their fifties having smoked cigarettes, been obese, or both. It is unknown to what extent risky behaviors (for example, smoking, having a poor diet, being physically inactive, and consuming an excessive amount of alcohol) collectively are reducing the health and life expectancy of the US population, or what improvements might be achievable in their absence. Using data from the Health and Retirement Study, we studied people ages fifty and older who had never smoked, who were not obese, and who consumed alcohol moderately...
July 19, 2017: Health Affairs
https://www.readbyqxmd.com/read/28721027/frequency-of-frailty-and-its-association-with-cognitive-status-and-survival-in-older-chileans
#14
Cecilia Albala, Lydia Lera, Hugo Sanchez, Barbara Angel, Carlos Márquez, Patricia Arroyo, Patricio Fuentes
BACKGROUND: Age-associated brain physiologic decline and reduced mobility are key elements of increased age-associated vulnerability. OBJECTIVE: To study the frequency of frailty phenotype and its association with mental health and survival in older Chileans. METHODS: Follow-up of ALEXANDROS cohorts designed to study disability associated with obesity in community-dwelling people 60 years and older living in Santiago, Chile. At baseline, 2,098 (67% women) of 2,372 participants were identified as having the frailty phenotype: weak handgrip dynamometry, unintentional weight loss, fatigue/exhaustion, five chair-stands/slow walking speed and difficulty walking (low physical activity)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28719557/functional-gain-and-pain-relief-after-total-joint-replacement-according-to-obesity-status
#15
Wenjun Li, David C Ayers, Courtland G Lewis, Thomas R Bowen, Jeroan J Allison, Patricia D Franklin
BACKGROUND: Obesity has been associated with lower function and more pain before and after total hip or knee replacement (THR or TKR). We examined the changes between preoperative and postoperative function and pain in a large representative U.S. cohort to determine if there was a relationship to obesity status. METHODS: Preoperative and 6-month postoperative data on function (Short Form-36 Physical Component Summary [PCS] score), joint pain (Hip disability and Osteoarthritis Outcome Score and Knee injury and Osteoarthritis Outcome Score), and body mass index (BMI) were collected from a national sample of 2,040 patients who had undergone THR and 2,964 who had undergone TKR from May 2011 to March 2013...
July 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28719232/long-term-outcomes-of-a-multidisciplinary-weight-management-intervention-for-youth-with-disabilities
#16
Ashleigh A Pona, Meredith L Dreyer Gillette, Cathleen Odar Stough, Janelle K Gerling, Brooke R Sweeney
BACKGROUND: Youth with disabilities are at increased risk for obesity compared with their typically developing peers and face unique barriers to healthy lifestyles. A limited number of weight management programs have been specifically tailored to accommodate youth with disabilities, and outcomes research in this population is scarce. We investigated the effectiveness of a specialized multidisciplinary weight management program for children with disabilities. METHODS: Youth (N = 115) ages 2-18 years (mean age = 10...
July 18, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28716070/comorbidity-and-metabolic-syndrome-in-patients-with-multiple-sclerosis-from-asturias-and-catalonia-spain
#17
Antoni Sicras-Mainar, Elena Ruíz-Beato, Ruth Navarro-Artieda, Jorge Maurino
BACKGROUND: The impact of comorbidity on multiple sclerosis (MS) is a new area of interest. Limited data on the risk factors of metabolic syndrome (MetS) is currently available. The aim of this study was to estimate the presence of comorbid conditions and MetS in a sample of adult patients with MS. METHODS: A retrospective, cohort study was conducted using electronic medical records from 19 primary care centres in Catalonia and Asturias, Spain. The number of chronic diseases (diagnoses), the Charlson Comorbidity Index and the individual Case-mix Index were used to assess general comorbidity variables...
July 17, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28707359/the-feasibility-of-using-pedometers-for-self-report-of-steps-and-accelerometers-for-measuring-physical-activity-in-adults-with-intellectual-and-developmental-disabilities-across-an-18-month-intervention
#18
L T Ptomey, E A Willis, J Lee, R A Washburn, C A Gibson, J J Honas, J E Donnelly
BACKGROUND: Improving physical activity in adults with intellectual and developmental disabilities (IDDs) is recommended to improve weight loss and general health. However, in order to determine the success of physical activity interventions, identification of feasible methods for assessment of physical activities is necessary. The purpose of this study is to assess the feasibility of adults with IDD to track daily steps and wear an accelerometer. METHODS: Overweight/obese adults with mild to moderate IDD followed a diet and physical activity program for 18 months...
August 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28705367/dynamic-magnetic-resonance-imaging-of-the-pelvic-floor
#19
Sindhura Alapati, Kedar Jambhekar
Pelvic floor dysfunction is a widespread condition affecting up to 50% of elderly women. It markedly compromises the quality of life owing to various disabling symptoms such as pelvic pain, pelvic organ prolapse, and urinary and fecal incontinence. Although age and female sex are the main risk factors, others include multiparity, obesity, and connective tissue disorders. Pelvic floor dysfunction is frequently multicompartmental, and failure to diagnose it accurately often leads to treatment failure. Dynamic pelvic floor magnetic resonance imaging is a robust tool that enables simultaneous visualization of the 3 pelvic floor compartments and is indispensable for precise preoperative evaluation...
June 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/28701628/study-of-chronic-pain-and-its-associated-risk-factors-among-japanese-industry-workers-the-quality-of-working-life-influenced-by-chronic-pain-qwlic-study
#20
Keiko Yamada, Kenta Wakaizumi, Kyosuke Fukai, Hiroyasu Iso, Tomotaka Sobue, Masahiko Shibata, Ko Matsudaira
OBJECTIVES: This study was performed to identify the prevalence, influence, and risk factors associated with chronic pain among Japanese industry workers. METHODS: We investigated 2,544 participants working at a manufacturing company A, a manufacturing company B, and 16 branch shops of a retail chain company C. The participants responded to self-administered questionnaires related to pain. Furthermore, data obtained from the lifestyle interview sheet of an annual health screening examination and those obtained from the questionnaires were merged...
July 13, 2017: Sangyō Eiseigaku Zasshi, Journal of Occupational Health
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