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obesity and disability

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https://www.readbyqxmd.com/read/29784605/code-seq-an-augmented-whole-exome-sequencing-enables-the-accurate-detection-of-cnvs-and-mutations-in-mendelian-obesity-and-intellectual-disability
#1
Louise Montagne, Mehdi Derhourhi, Amélie Piton, Bénédicte Toussaint, Emmanuelle Durand, Emmanuel Vaillant, Dorothée Thuillier, Stefan Gaget, Franck De Graeve, Iandry Rabearivelo, Amélie Lansiaux, Bruno Lenne, Sylvie Sukno, Rachel Desailloud, Miriam Cnop, Ramona Nicolescu, Lior Cohen, Jean-François Zagury, Mélanie Amouyal, Jacques Weill, Jean Muller, Olivier Sand, Bruno Delobel, Philippe Froguel, Amélie Bonnefond
OBJECTIVE: The molecular diagnosis of extreme forms of obesity, in which accurate detection of both copy number variations (CNVs) and point mutations, is crucial for an optimal care of the patients and genetic counseling for their families. Whole-exome sequencing (WES) has benefited considerably this molecular diagnosis, but its poor ability to detect CNVs remains a major limitation. We aimed to develop a method (CoDE-seq) enabling the accurate detection of both CNVs and point mutations in one step...
May 16, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29779408/the-relationship-between-employment-and-health-and-health-care-among-working-age-adults-with-and-without-disabilities-in-the-united-states
#2
Amanda Reichard, Michelle Stransky, Debra Brucker, Andrew Houtenville
PURPOSE: To better understand the relationship between employment and health and health care for people with disabilities in the United States (US). METHODS: We pooled US Medical Expenditure Panel Survey (2004-2010) data to examine health status, and access to health care among working-age adults, comparing people with physical disabilities or multiple disabilities to people without disabilities, based on their employment status. Logistic regression and least squares regression were conducted, controlling for sociodemographics, health insurance (when not the outcome), multiple chronic conditions, and need for assistance...
May 20, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29772872/spatial-analysis-for-the-epidemiological-study-of-cardiovascular-diseases-a-systematic-literature-search
#3
Carlos Mena, Cesar Sepúlveda, Eduardo Fuentes, Yony Ormazábal, Iván Palomo
Cardiovascular diseases (CVDs) are the primary cause of death and disability in de world, and the detection of populations at risk as well as localization of vulnerable areas is essential for adequate epidemiological management. Techniques developed for spatial analysis, among them geographical information systems and spatial statistics, such as cluster detection and spatial correlation, are useful for the study of the distribution of the CVDs. These techniques, enabling recognition of events at different geographical levels of study (e...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29771779/cost-of-integrating-non-communicable-disease-screening-into-home-based-hiv-testing-and-counseling-in-south-africa
#4
Ilya Golovaty, Monisha Sharma, Alastair Van Heerden, Heidi van Rooyen, Jared M Baeten, Connie Celum, Ruanne V Barnabas
INTRODUCTION: Integrated HIV-non-communicable disease (NCD) services have the potential to avert death and disability, but require data on program costs to assess the impact of integrated services on affordability. METHODS: We estimated the incremental costs of NCD screening as part of home-based HIV testing and counseling (HTC) and referral to care in KwaZulu-Natal, South Africa. All adults in the households were offered integrated HIV-NCD screening (for HIV, diabetes, hypertension, hypercholesterolemia, obesity, depression, tobacco and alcohol use), counseling, and linkage to care...
May 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29764322/biting-the-hands-that-feed-the-alligators-a-case-study-in-morbid-obesity-extremes-end-of-life-care-and-prohibitions-on-harming-and-accelerating-the-end-of-life
#5
Michael J Malinowski
Obesity, recognized as a disease in the U.S. and at times as a terminal illness due to associated medical complications, is an American epidemic according to the Centers for Disease Control and Prevention ("CDC"), American Heart Association ("AHA"), and other authorities. More than one third of Americans (39.8% of adults and 18.5% of children) are medically obese. This article focuses on cases of "extreme morbid obesity" ("EMO")-situations in which death is imminent without aggressive medical interventions, and bariatric surgery is the only treatment option with a realistic possibility of success...
March 2018: American Journal of Law & Medicine
https://www.readbyqxmd.com/read/29764278/eating-well-living-well-and-weight-management-a-co-produced-semi-qualitative-study-of-barriers-and-facilitators-experienced-by-adults-with-intellectual-disabilities
#6
A J Doherty, S P Jones, U Chauhan, Jme Gibson
Adults with intellectual disabilities in England experience health inequalities. They are more likely than their non-disabled peers to be obese and at risk of serious medical conditions such as heart disease, stroke and type 2 diabetes. This semi-qualitative study engaged adults with intellectual disabilities in a co-production process to explore their perceived barriers and facilitators to eating well, living well and weight management. Nineteen participants with intellectual disabilities took part in four focus groups and one wider group discussion...
January 1, 2018: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/29761882/the-prevalence-of-obesity-in-children-and-young-people-with-down-syndrome
#7
Muireann O' Shea, Carol O' Shea, Louise Gibson, Jennifer Leo, Catherine Carty
BACKGROUND: Overweight and obesity is a growing concern among individuals with intellectual disabilities; however, little is known about the prevalence among children and youth with Down syndrome (CYDS). The purpose of this study was to determine the prevalence of overweight/obesity among CYDS in South West Ireland. METHODS: This cross-sectional study measured height and weight of 61 CYDS aged 4-16 years. Body mass index (BMI) was calculated and percentage body fat (PBF) was measured using bio-electrical impendence analysis (BIA)...
May 15, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/29761539/-fat-is-really-a-four-letter-word-exploring-weight-related-communication-best-practices-in-children-with-and-without-disabilities-and-their-caregivers
#8
A C McPherson, T J Knibbe, M Oake, J A Swift, N Browne, G D C Ball, J Hamilton
BACKGROUND: Health care professionals play a critical role in preventing and managing childhood obesity, but the American Academy of Pediatrics recently stressed the importance of using sensitive and nonstigmatizing language when discussing weight with children and families. Although barriers to weight-related discussions are well known, there are few evidence-based recommendations around communication best practices. Disability populations in particular have previously been excluded from work in this area...
May 15, 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29758347/gene-analysis-a-rare-gene-disease-of-intellectual-deficiency-cohen-syndrome
#9
Chengqing Yang, Mei Hou, Yutang Li, Dianrong Sun, Ya Guo, Peipei Liu, Yedan Liu, Jie Song, Na Zhang, Wei Wei, Zongbo Chen
Cohen syndrome is a rare, genetic, connective-tissue disorder, which is caused by mutations in the gene COH1 (VPS13B, Vacuolar Protein Sorting 13 Homolog B) at the chromosome 8q22. The disease is rare reported, which major clinical features include postnatal microcephaly, obesity, short stature, intellectual disability, progressive retinal dystrophy, intermittent neutropenia and many other unusual facial feature. We report four patients in China who were diagnosed with Cohen syndrome by genetic testing and clinical manifestations...
May 11, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29748963/body-mass-index-and-cardiorespiratory-fitness-in-persons-with-multiple-sclerosis
#10
E Sebastião, R W Motl
OBJECTIVE: This study examined body fatness and its association with cardiorespiratory fitness (CRF) in persons with multiple sclerosis (pwMS) accounting for disability status. MATERIALS AND METHODS: This study involved a secondary data analysis from a previous study of 62 pwMS. Body fatness was indirect measured as body mass index (BMI), and CRF was measured as peak oxygen consumption from an incremental exercise test with spirometry. Participants were allocated into 3 different groups based on established BMI categories (ie, normal, overweight, and obese), and data were analyzed using SPSS...
May 11, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29730431/mayer-rokitansky-kuster-hauser-syndrome-and-16p11-2-recurrent-microdeletion-a-case-report-and-review-of-the-literature
#11
Marta Gatti, Gianluca Tolva, Silvia Bergamaschi, Claudia Giavoli, Susanna Esposito, Paola Marchisio, Donatella Milani
BACKGROUND: Mayer-Rokitansky-Kuster-Hauser syndrome (OMIM #277000) is a rare disorder of the female reproductive tract. Its etiology is still unknown for the majority of patients, even if the genetic background of this condition has been intensively studied. Chromosome 16p11.2 deletion syndrome (OMIM # 611913) is a well-known recurrent deletion syndrome that can present with various clinical phenotypes, including developmental delay, intellectual disability, autism spectrum disorder, obesity, and an increased frequency of congenital defects...
May 3, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29727867/coronal-knee-malalignment-in-young-adults-and-its-link-to-body-measures
#12
Oded Hershkovich, Ran Thein, Barak Gordon, Gideon Burstein, Shay Tenenbaum, Estela Derazne, Dorit Tzur, Arnon Afek
Our aim was to report the prevalence of knee varus-valgus malalignment (KVVM) and its association with body mass index (BMI) and body height in a healthy and fit young adult population. Information on the disability codes associated with KVVM according to the Regulations of Medical Fitness Determination was retrieved from a medical database containing records of 17-year-old males and females before their recruitment into mandatory military service. Logistic regression models assessed the association between the BMI and body height to KVVM...
May 4, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29727300/rab23-and-developmental-disorders
#13
Catherine H H Hor, Bor Luen Tang, Eyleen L K Goh
Rab23 is a conserved member of the Rab family of small GTPases that regulates membrane trafficking in eukaryotes. It is unique amongst the Rabs in terms of its implicated role in mammalian development, as originally illustrated by the embryonic lethality and open neural tube phenotype of a spontaneous mouse mutant that carries homozygous mutation of open brain, a gene encoding Rab23. Rab23 was initially identified to act as an antagonist of Sonic hedgehog (Shh) signaling, and has since been implicated in a number of physiological and pathological roles, including oncogenesis...
May 4, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29725171/does-metabolic-syndrome-determine-severity-and-disability-of-chronic-low-backache
#14
Jayantee Kalita, Kamlesh Kumar Sonkar, Usha Kant Misra, Sanjeev K Bhoi
Introduction: Obesity may be associated with more severe and disabling low backache (LBA) due to alteration in biomechanics, but there are no such studies from developing countries. Aims: We report the frequency of metabolic syndrome (MS) in chronic LBA (CLBA) and its association with severity and disability of CLBA. Subjects and Methods: Consecutive patients with CLBA attending to the neurology service from October 2015 to February 2016 were included in the study...
April 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29724488/factors-contributing-to-disability-in-rheumatoid-arthritis-patients-an-egyptian-multicenter-study
#15
Marwa Hammad, Mervat Eissa, Ghada A Dawa
OBJECTIVE: Minimizing disability and enhancing physical function to its optimal levels is still a challenge in management of rheumatoid arthritis (RA). The aim is to identify factors leading to disability in RA. METHODS: This is a cross-sectional Egyptian multicenter study carried out on 215 RA patients attending to our inpatient and outpatient rheumatology clinics during 4 months starting from April to July 2017 who agreed to participate in the study; 170 patients were from Cairo University hospitals and 45 from Zagazig University hospitals...
April 30, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29723172/health-care-provider-counseling-for-weight-loss-among-adults-with-arthritis-and-overweight-or-obesity-united-states-2002-2014
#16
Dana Guglielmo, Jennifer M Hootman, Louise B Murphy, Michael A Boring, Kristina A Theis, Brook Belay, Kamil E Barbour, Miriam G Cisternas, Charles G Helmick
In the United States, 54.4 million adults report having doctor-diagnosed arthritis (1). Among adults with arthritis, 32.7% and 38.1% also have overweight and obesity, respectively (1), with obesity being more prevalent among persons with arthritis than among those who do not have arthritis (2). Furthermore, severe joint pain among adults with arthritis in 2014 was reported by 23.5% of adults with overweight and 31.7% of adults with obesity (3). The American College of Rheumatology recommends weight loss for adults with hip or knee osteoarthritis and overweight or obesity,* which can improve function and mobility while reducing pain and disability (4,5)...
May 4, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29718951/the-complementary-health-approaches-for-pain-survey-chaps-validity-testing-and-characteristics-of-a-rural-population-with-pain
#17
Termeh Feinberg, Dina L Jones, Christa Lilly, Amna Umer, Kim Innes
OBJECTIVES: Little is known about patterns and correlates of Complementary Health Approaches (CHAs) in chronic pain populations, particularly in rural, underserved communities. This article details the development and implementation of a new survey instrument designed to address this gap, the Complementary Health Approaches for Pain Survey (CHAPS). DESIGN: Following pilot-testing using pre-specified criteria to assess quality and comprehension in our target population, and after feedback regarding face-validity from content experts and stakeholders, the final cross-sectional self-report survey required 10-12 minutes to complete...
2018: PloS One
https://www.readbyqxmd.com/read/29707921/obesity-weight-loss-and-progression-of-disability-in-rheumatoid-arthritis
#18
Joshua F Baker, Bryant R England, Ted R Mikuls, Harlan Sayles, Grant W Cannon, Brian C Sauer, Michael D George, Liron Caplan, Kaleb Michaud
BACKGROUND: Obese patients with rheumatoid arthritis (RA) report greater disability in cross-sectional studies. The longitudinal effects of obesity, however, are not well-characterized. We evaluated associations between obesity, weight loss, and worsening of disability in two large registry studies with long-term follow-up. METHODS: This study included patients with RA from the National Data Bank of Rheumatic Diseases (Forward) (N=23,323) and the Veterans Affairs RA (VARA) registry study (N=1,697)...
April 29, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29704885/parental-chronic-widespread-pain-and-the-association-with-chronic-widespread-pain-in-adult-offspring-family-linkage-data-from-the-norwegian-hunt-study
#19
J R Zadro, T I L Nilsen, D Shirley, A B Amorim, P H Ferreira, P J Mork
BACKGROUND: Individuals experiencing chronic widespread pain (CWP) have greater disability and poorer quality-of-life compared to those with other chronic painful conditions; although research identifying risk factors for CWP is lacking. We aimed to investigate if parental CWP increases the risk of offspring CWP, and if offspring body mass index (BMI) and leisure-time physical activity modify this association. METHODS: We included 6,589 parent-offspring trios participating in the Norwegian HUNT Study in 1995-97 and 2006-08...
April 28, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29704285/walking-velocity-and-step-length-adjustments-affect-knee-joint-contact-forces-in-healthy-weight-and-obese-adults
#20
Clare E Milner, Stacey A Meardon, Jillian L Hawkins, John D Willson
Knee osteoarthritis is a major public health problem and adults with obesity are particularly at risk. One approach to alleviating this problem is to reduce the mechanical load at the joint during daily activity. Adjusting temporospatial parameters of walking could mitigate cumulative knee joint mechanical loads. The purpose of this study was to determine how adjustments to velocity and step length affects knee joint loading in healthy weight adults and adults with obesity. We collected three-dimensional gait analysis data on 10 adults with a normal body mass index and 10 adults with obesity during over ground walking in nine different conditions...
April 28, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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